MCID: ACT234
MIFTS: 20

Acute Myeloid Leukemia with Minimal Differentiation

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Acute Myeloid Leukemia with Minimal Differentiation

MalaCards integrated aliases for Acute Myeloid Leukemia with Minimal Differentiation:

Name: Acute Myeloid Leukemia with Minimal Differentiation 58
Minimally Differentiated Acute Myeloblastic Leukemia 58 17
Aml M0 58

Characteristics:

Orphanet epidemiological data:

58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C92.0
UMLS via Orphanet 71 C0522631
Orphanet 58 ORPHA98832

Summaries for Acute Myeloid Leukemia with Minimal Differentiation

MalaCards based summary : Acute Myeloid Leukemia with Minimal Differentiation, also known as minimally differentiated acute myeloblastic leukemia, is related to myeloid leukemia and myeloid sarcoma. An important gene associated with Acute Myeloid Leukemia with Minimal Differentiation is FLT3 (Fms Related Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are Endometrial cancer and Transcriptional misregulation in cancer. Affiliated tissues include myeloid and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Acute Myeloid Leukemia with Minimal Differentiation

Diseases related to Acute Myeloid Leukemia with Minimal Differentiation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 myeloid leukemia 30.5 MPO FLT3
2 myeloid sarcoma 30.0 MPO FLT3
3 acute leukemia 30.0 MPO FLT3
4 leukemia, acute myeloid 30.0 MPO FLT3
5 blood platelet disease 29.9 MPO FLT3
6 aplastic anemia 29.9 MPO FLT3
7 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 29.8 MPO FLT3
8 leukemia, acute monocytic 29.7 MPO FLT3
9 leukemia, acute lymphoblastic 29.7 MPO FLT3
10 monocytic leukemia 29.7 MPO FLT3
11 myelofibrosis 29.6 MPO FLT3
12 myelodysplastic syndrome 29.6 MPO FLT3
13 patau syndrome 10.3
14 leukemia 10.3
15 chromosomal triplication 10.3
16 down syndrome 10.3
17 acute myeloblastic leukemia without maturation 10.3
18 tetrasomy 18p 10.2
19 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.2
20 sarcoma 10.2
21 pancytopenia 10.2
22 acute kidney failure 10.2
23 spindle cell sarcoma 10.2
24 acute monoblastic/monocytic leukemia 10.2
25 progressive familial heart block, type ia 10.0
26 lymphoma, hodgkin, classic 10.0
27 polycythemia vera 10.0
28 platelet disorder, familial, with associated myeloid malignancy 10.0
29 progressive familial heart block, type ib 10.0
30 lymphoma, non-hodgkin, familial 10.0
31 thrombosis 10.0
32 right bundle branch block 10.0
33 hematologic cancer 10.0
34 polycythemia 10.0
35 acute monoblastic leukemia 10.0
36 acute myeloblastic leukemia with maturation 10.0
37 tetraploidy 10.0
38 t-cell non-hodgkin lymphoma 10.0
39 neutrophilia, hereditary 9.8 MPO FLT3
40 mixed phenotype acute leukemia 9.8 MPO FLT3
41 leukostasis 9.8 MPO FLT3
42 precursor t-cell acute lymphoblastic leukemia 9.8 MPO FLT3
43 acute megakaryocytic leukemia 9.8 MPO FLT3
44 b-lymphoblastic leukemia/lymphoma 9.8 MPO FLT3
45 blood coagulation disease 9.8 MPO FLT3
46 severe congenital neutropenia 9.8 MPO FLT3
47 neutropenia 9.8 MPO FLT3
48 chronic myelomonocytic leukemia 9.8 MPO FLT3
49 myeloproliferative neoplasm 9.8 MPO FLT3
50 leukemia, chronic myeloid 9.7 MPO FLT3

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with Minimal Differentiation:



Diseases related to Acute Myeloid Leukemia with Minimal Differentiation

Symptoms & Phenotypes for Acute Myeloid Leukemia with Minimal Differentiation

GenomeRNAi Phenotypes related to Acute Myeloid Leukemia with Minimal Differentiation according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.44 FLT3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.44 FLT3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.44 MPO
4 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.44 MPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.44 FLT3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.44 MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.44 FLT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.44 MPO
9 Increased shRNA abundance (Z-score > 2) GR00366-A-40 9.44 MPO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.44 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.44 MPO
12 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.44 FLT3 MPO

Drugs & Therapeutics for Acute Myeloid Leukemia with Minimal Differentiation

Search Clinical Trials , NIH Clinical Center for Acute Myeloid Leukemia with Minimal Differentiation

Genetic Tests for Acute Myeloid Leukemia with Minimal Differentiation

Anatomical Context for Acute Myeloid Leukemia with Minimal Differentiation

MalaCards organs/tissues related to Acute Myeloid Leukemia with Minimal Differentiation:

40
Myeloid, Bone Marrow

Publications for Acute Myeloid Leukemia with Minimal Differentiation

Articles related to Acute Myeloid Leukemia with Minimal Differentiation:

(show all 11)
# Title Authors PMID Year
1
Clinical, immunophenotypic, and genomic findings of acute undifferentiated leukemia and comparison to acute myeloid leukemia with minimal differentiation: a study from the bone marrow pathology group. 61
31000771 2019
2
Acute myeloid leukemia with minimal differentiation (AML M0) mimicking acute lymphoblastic leukemia. 61
30431665 2019
3
Acute leukemias of ambiguous origin. 61
26276768 2015
4
TdT expression in acute myeloid leukemia with minimal differentiation is associated with distinctive clinicopathological features and better overall survival following stem cell transplantation. 61
22936064 2013
5
A tetraploid minimally differentiated acute myeloblastic leukemia with extensive erythrophagocytosis: a case report and literature review. 61
23054644 2012
6
Acute myeloid leukemia with minimal differentiation: unusual cytogenetics, morphology, phenotype and clinical course. 61
22483069 2012
7
p-Iodophenol-enhanced luminol chemiluminescent assay applied to discrimination between acute lymphoblastic and minimally differentiated acute myeloid (FAB-M0) or acute megakaryoblastic (FAB-M7) leukemias. 61
15570291 2004
8
M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: a report of 59 cases by the Groupe Français d'Hématologie Cellulaire (GFHC) and the Groupe Français de Cytogénétique Hématologique (GFCH). 61
12393381 2003
9
Acute myeloid leukemia with minimal differentiation. A multiple parameter study. 61
9426515 1998
10
Translocations between the long arms of chromosomes 1 and 5 in hematologic malignancies are strongly associated with neoplasms of the myeloid lineages. 61
9398862 1997
11
Development of minimally differentiated acute myeloblastic leukemia with novel isochromosome 18p and antecedent aplastic anemia. 61
8956860 1996

Variations for Acute Myeloid Leukemia with Minimal Differentiation

Expression for Acute Myeloid Leukemia with Minimal Differentiation

Search GEO for disease gene expression data for Acute Myeloid Leukemia with Minimal Differentiation.

Pathways for Acute Myeloid Leukemia with Minimal Differentiation

Pathways related to Acute Myeloid Leukemia with Minimal Differentiation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.9 MPO FLT3
2 11.24 MPO FLT3
3 10.69 MPO FLT3

GO Terms for Acute Myeloid Leukemia with Minimal Differentiation

Sources for Acute Myeloid Leukemia with Minimal Differentiation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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