MCID: ACT234
MIFTS: 21

Acute Myeloid Leukemia with Minimal Differentiation

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Acute Myeloid Leukemia with Minimal Differentiation

MalaCards integrated aliases for Acute Myeloid Leukemia with Minimal Differentiation:

Name: Acute Myeloid Leukemia with Minimal Differentiation 59
Minimally Differentiated Acute Myeloblastic Leukemia 59
Aml M0 59

Characteristics:

Orphanet epidemiological data:

59

Classifications:



External Ids:

Orphanet 59 ORPHA98832
UMLS via Orphanet 74 C0522631
ICD10 via Orphanet 34 C92.0

Summaries for Acute Myeloid Leukemia with Minimal Differentiation

MalaCards based summary : Acute Myeloid Leukemia with Minimal Differentiation, also known as minimally differentiated acute myeloblastic leukemia, is related to myeloid sarcoma and leukemia, acute myeloid. An important gene associated with Acute Myeloid Leukemia with Minimal Differentiation is FLT3 (Fms Related Tyrosine Kinase 3), and among its related pathways/superpathways are Endometrial cancer and Transcriptional misregulation in cancer. Affiliated tissues include myeloid, bone and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Acute Myeloid Leukemia with Minimal Differentiation

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with Minimal Differentiation:



Diseases related to Acute Myeloid Leukemia with Minimal Differentiation

Symptoms & Phenotypes for Acute Myeloid Leukemia with Minimal Differentiation

GenomeRNAi Phenotypes related to Acute Myeloid Leukemia with Minimal Differentiation according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.6 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.6 FLT3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.6 FLT3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.6 FLT3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.6 FLT3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.6 FLT3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.6 FLT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.6 MPO
9 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.6 MPO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.6 FLT3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.6 MPO
12 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.6 MPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.6 FLT3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.6 MPO
15 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.6 MPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.6 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.6 MPO
18 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.6 FLT3 MPO

Drugs & Therapeutics for Acute Myeloid Leukemia with Minimal Differentiation

Search Clinical Trials , NIH Clinical Center for Acute Myeloid Leukemia with Minimal Differentiation

Genetic Tests for Acute Myeloid Leukemia with Minimal Differentiation

Anatomical Context for Acute Myeloid Leukemia with Minimal Differentiation

MalaCards organs/tissues related to Acute Myeloid Leukemia with Minimal Differentiation:

41
Myeloid, Bone, T Cells, Bone Marrow

Publications for Acute Myeloid Leukemia with Minimal Differentiation

Articles related to Acute Myeloid Leukemia with Minimal Differentiation:

# Title Authors Year
1
Acute myeloid leukemia with minimal differentiation (AML M0) mimicking acute lymphoblastic leukemia. ( 30431665 )
2018
2
TdT expression in acute myeloid leukemia with minimal differentiation is associated with distinctive clinicopathological features and better overall survival following stem cell transplantation. ( 22936064 )
2013
3
Acute myeloid leukemia with minimal differentiation: unusual cytogenetics, morphology, phenotype and clinical course. ( 22483069 )
2012
4
Acute myeloid leukemia with minimal differentiation. A multiple parameter study. ( 9426515 )
1998

Variations for Acute Myeloid Leukemia with Minimal Differentiation

Expression for Acute Myeloid Leukemia with Minimal Differentiation

Search GEO for disease gene expression data for Acute Myeloid Leukemia with Minimal Differentiation.

Pathways for Acute Myeloid Leukemia with Minimal Differentiation

Pathways related to Acute Myeloid Leukemia with Minimal Differentiation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.9 FLT3 MPO
2 11.23 FLT3 MPO
3 10.69 FLT3 MPO

GO Terms for Acute Myeloid Leukemia with Minimal Differentiation

Biological processes related to Acute Myeloid Leukemia with Minimal Differentiation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 8.62 FLT3 MPO

Sources for Acute Myeloid Leukemia with Minimal Differentiation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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