MCID: ACT234
MIFTS: 22

Acute Myeloid Leukemia with Minimal Differentiation

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Acute Myeloid Leukemia with Minimal Differentiation

MalaCards integrated aliases for Acute Myeloid Leukemia with Minimal Differentiation:

Name: Acute Myeloid Leukemia with Minimal Differentiation 60
Minimally Differentiated Acute Myeloblastic Leukemia 60 17
Aml M0 60

Characteristics:

Orphanet epidemiological data:

60

Classifications:



External Ids:

ICD10 via Orphanet 35 C92.0
UMLS via Orphanet 75 C0522631
Orphanet 60 ORPHA98832

Summaries for Acute Myeloid Leukemia with Minimal Differentiation

MalaCards based summary : Acute Myeloid Leukemia with Minimal Differentiation, also known as minimally differentiated acute myeloblastic leukemia, is related to myeloid sarcoma and leukemia, acute myeloid. An important gene associated with Acute Myeloid Leukemia with Minimal Differentiation is FLT3 (Fms Related Tyrosine Kinase 3), and among its related pathways/superpathways are Endometrial cancer and Transcriptional misregulation in cancer. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Acute Myeloid Leukemia with Minimal Differentiation

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with Minimal Differentiation:



Diseases related to Acute Myeloid Leukemia with Minimal Differentiation

Symptoms & Phenotypes for Acute Myeloid Leukemia with Minimal Differentiation

GenomeRNAi Phenotypes related to Acute Myeloid Leukemia with Minimal Differentiation according to GeneCards Suite gene sharing:

27 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.62 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.62 FLT3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.62 FLT3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.62 FLT3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.62 FLT3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.62 FLT3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.62 FLT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.62 FLT3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.62 MPO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.62 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.62 FLT3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.62 MPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.62 MPO
14 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.62 FLT3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.62 MPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.62 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.62 MPO
18 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.62 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.62 FLT3 MPO

Drugs & Therapeutics for Acute Myeloid Leukemia with Minimal Differentiation

Search Clinical Trials , NIH Clinical Center for Acute Myeloid Leukemia with Minimal Differentiation

Genetic Tests for Acute Myeloid Leukemia with Minimal Differentiation

Anatomical Context for Acute Myeloid Leukemia with Minimal Differentiation

MalaCards organs/tissues related to Acute Myeloid Leukemia with Minimal Differentiation:

42
Myeloid, Bone, Bone Marrow, T Cells

Publications for Acute Myeloid Leukemia with Minimal Differentiation

Articles related to Acute Myeloid Leukemia with Minimal Differentiation:

# Title Authors Year
1
Clinical, immunophenotypic, and genomic findings of acute undifferentiated leukemia and comparison to acute myeloid leukemia with minimal differentiation: a study from the bone marrow pathology group. ( 31000771 )
2019
2
Acute myeloid leukemia with minimal differentiation (AML M0) mimicking acute lymphoblastic leukemia. ( 30431665 )
2018
3
TdT expression in acute myeloid leukemia with minimal differentiation is associated with distinctive clinicopathological features and better overall survival following stem cell transplantation. ( 22936064 )
2013
4
Acute myeloid leukemia with minimal differentiation: unusual cytogenetics, morphology, phenotype and clinical course. ( 22483069 )
2012
5
Acute myeloid leukemia with minimal differentiation. A multiple parameter study. ( 9426515 )
1998
6
Development of minimally differentiated acute myeloblastic leukemia with novel isochromosome 18p and antecedent aplastic anemia. ( 8956860 )
1996

Variations for Acute Myeloid Leukemia with Minimal Differentiation

Expression for Acute Myeloid Leukemia with Minimal Differentiation

Search GEO for disease gene expression data for Acute Myeloid Leukemia with Minimal Differentiation.

Pathways for Acute Myeloid Leukemia with Minimal Differentiation

Pathways related to Acute Myeloid Leukemia with Minimal Differentiation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.9 FLT3 MPO
2 11.23 FLT3 MPO
3 10.69 FLT3 MPO

GO Terms for Acute Myeloid Leukemia with Minimal Differentiation

Biological processes related to Acute Myeloid Leukemia with Minimal Differentiation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 8.32 MPO

Sources for Acute Myeloid Leukemia with Minimal Differentiation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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