MCID: ACT190
MIFTS: 14

Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

MalaCards integrated aliases for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation:

Name: Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation 58
Aml with T(8;16)(p11;p13) Translocation 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C92.0
Orphanet 58 ORPHA370026

Summaries for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

MalaCards based summary : Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation, also known as aml with t(8;16)(p11;p13) translocation, is related to leukemia, acute myeloid and myeloid leukemia. An important gene associated with Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation is CREBBP (CREB Binding Protein), and among its related pathways/superpathways are Chromatin organization and Regulation of TP53 Activity. Affiliated tissues include myeloid.

Related Diseases for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Diseases in the Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation family:

Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Diseases related to Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 29.9 KAT6A CREBBP
2 myeloid leukemia 10.5
3 neonatal leukemia 9.7 KAT6A CREBBP
4 leukemia, acute monocytic 9.7 KAT6A CREBBP
5 chromosome 16p13.3 deletion syndrome, proximal 9.7 KAT6A CREBBP
6 chronic myelomonocytic leukemia 9.7 KAT6A CREBBP
7 autosomal dominant non-syndromic intellectual disability 9.6 KAT6A CREBBP
8 myelodysplastic syndrome 9.6 KAT6A CREBBP

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation:



Diseases related to Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Symptoms & Phenotypes for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Drugs & Therapeutics for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Search Clinical Trials , NIH Clinical Center for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Genetic Tests for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Anatomical Context for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

MalaCards organs/tissues related to Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation:

40
Myeloid

Publications for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Articles related to Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation:

# Title Authors PMID Year
1
Type I MOZ/CBP (MYST3/CREBBP) is the most common chimeric transcript in acute myeloid leukemia with t(8;16)(p11;p13) translocation. 61
15101047 2004

Variations for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Expression for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Search GEO for disease gene expression data for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation.

Pathways for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Pathways related to Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12 KAT6A CREBBP
2
Show member pathways
11.77 KAT6A CREBBP
3 10.44 KAT6A CREBBP

GO Terms for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Biological processes related to Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.16 KAT6A CREBBP
2 histone acetylation GO:0016573 8.96 KAT6A CREBBP
3 protein acetylation GO:0006473 8.62 KAT6A CREBBP

Molecular functions related to Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.37 KAT6A CREBBP
2 transcription coactivator activity GO:0003713 9.32 KAT6A CREBBP
3 transferase activity, transferring acyl groups GO:0016746 9.26 KAT6A CREBBP
4 transcription coregulator activity GO:0003712 9.16 KAT6A CREBBP
5 histone acetyltransferase activity GO:0004402 8.96 KAT6A CREBBP
6 acetyltransferase activity GO:0016407 8.62 KAT6A CREBBP

Sources for Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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