MCID: ACT194
MIFTS: 25

Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Categories: Blood diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

MalaCards integrated aliases for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:

Name: Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation 59
Aml with T(8;21)(q22;q22) Translocation 59

Classifications:



External Ids:

Orphanet 59 ORPHA102724
ICD10 via Orphanet 34 C92.0

Summaries for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

MalaCards based summary : Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation, also known as aml with t(8;21)(q22;q22) translocation, is related to aleukemic leukemia cutis and acute myeloblastic leukemia with maturation. An important gene associated with Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation is RUNX1 (Runt Related Transcription Factor 1), and among its related pathways/superpathways are Endometrial cancer and NF-kappaB Signaling. Affiliated tissues include myeloid, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Diseases in the Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation family:

Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Diseases related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 aleukemic leukemia cutis 10.0 FLT3 RUNX1
2 acute myeloblastic leukemia with maturation 9.9 FLT3 KIT
3 multiple cranial nerve palsy 9.9 RUNX1 RUNX1T1
4 chronic eosinophilic leukemia 9.8 FLT3 KIT
5 leukemia, acute lymphoblastic 3 9.8 FLT3 RUNX1
6 myeloid sarcoma 9.7 FLT3 KIT
7 leukemia, acute lymphoblastic 9.7 FLT3 RUNX1
8 cytogenetically normal acute myeloid leukemia 9.6 CEBPA FLT3
9 juvenile myelomonocytic leukemia 9.4 FLT3 RUNX1
10 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.4 FLT3 KIT RUNX1
11 8p11 myeloproliferative syndrome 9.4 FLT3 KIT RUNX1
12 chronic myelomonocytic leukemia 9.4 FLT3 KIT RUNX1
13 bone marrow cancer 9.3 FLT3 KIT RUNX1
14 leukemia, chronic myeloid 9.3 FLT3 KIT RUNX1
15 acute promyelocytic leukemia 9.0 CEBPA FLT3 RUNX1
16 hematologic cancer 8.8 FLT3 KIT RUNX1 RUNX1T1
17 core binding factor acute myeloid leukemia 8.5 CEBPA FLT3 KIT RUNX1
18 acute leukemia 8.5 CEBPA FLT3 KIT RUNX1
19 myelodysplastic syndrome 8.4 CEBPA FLT3 KIT RUNX1
20 myeloid leukemia 7.9 CEBPA FLT3 KIT RUNX1 RUNX1T1
21 leukemia, acute myeloid 7.9 CEBPA FLT3 KIT RUNX1 RUNX1T1
22 leukemia 7.8 CEBPA FLT3 KIT RUNX1 RUNX1T1

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:



Diseases related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Symptoms & Phenotypes for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

GenomeRNAi Phenotypes related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.26 KIT
2 Decreased substrate adherent cell growth GR00193-A-2 9.26 KIT
3 Decreased substrate adherent cell growth GR00193-A-4 9.26 FLT3 KIT
4 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.62 FLT3 KIT

MGI Mouse Phenotypes related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.77 CEBPA FLT3 KIT RUNX1 RUNX1T1
2 endocrine/exocrine gland MP:0005379 9.71 CEBPA FLT3 KIT RUNX1
3 mortality/aging MP:0010768 9.65 FLT3 KIT RUNX1 RUNX1T1 CEBPA
4 integument MP:0010771 9.62 CEBPA KIT RUNX1 RUNX1T1
5 neoplasm MP:0002006 9.46 CEBPA FLT3 KIT RUNX1
6 no phenotypic analysis MP:0003012 9.26 CEBPA FLT3 KIT RUNX1
7 normal MP:0002873 8.92 CEBPA KIT RUNX1 RUNX1T1

Drugs & Therapeutics for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Search Clinical Trials , NIH Clinical Center for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Genetic Tests for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Anatomical Context for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

MalaCards organs/tissues related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:

41
Myeloid

Publications for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Variations for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Expression for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Search GEO for disease gene expression data for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation.

Pathways for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

GO Terms for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Biological processes related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.49 FLT3 KIT
2 negative regulation of signal transduction GO:0009968 9.48 FLT3 KIT
3 positive regulation of kinase activity GO:0033674 9.46 FLT3 KIT
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.43 FLT3 KIT
5 cytokine-mediated signaling pathway GO:0019221 9.43 CEBPA FLT3 KIT
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.4 FLT3 KIT
7 positive regulation of MAP kinase activity GO:0043406 9.37 FLT3 KIT
8 generation of precursor metabolites and energy GO:0006091 9.32 CEBPA RUNX1T1
9 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.16 FLT3 KIT
10 myeloid progenitor cell differentiation GO:0002318 8.96 FLT3 KIT
11 hemopoiesis GO:0030097 8.8 FLT3 KIT RUNX1

Molecular functions related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase kinase activity GO:0004709 9.26 FLT3 KIT
2 mitogen-activated protein kinase kinase binding GO:0031434 9.16 FLT3 KIT
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.96 FLT3 KIT
4 growth factor binding GO:0019838 8.62 FLT3 KIT

Sources for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
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28 GO
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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