MCID: ACT194
MIFTS: 28

Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

MalaCards integrated aliases for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:

Name: Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation 60
Aml with T(8;21)(q22;q22) Translocation 60

Classifications:



External Ids:

ICD10 via Orphanet 35 C92.0
Orphanet 60 ORPHA102724

Summaries for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

MalaCards based summary : Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation, also known as aml with t(8;21)(q22;q22) translocation, is related to myeloid sarcoma and myeloid leukemia. An important gene associated with Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation is RUNX1T1 (RUNX1 Partner Transcriptional Co-Repressor 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:



Diseases related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Symptoms & Phenotypes for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

GenomeRNAi Phenotypes related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.26 KIT
2 Decreased substrate adherent cell growth GR00193-A-2 9.26 KIT
3 Decreased substrate adherent cell growth GR00193-A-4 9.26 FLT3 KIT
4 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.62 FLT3 KIT

MGI Mouse Phenotypes related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 CEBPA FLT3 HHEX KIT RUNX1 RUNX1T1
2 cardiovascular system MP:0005385 9.89 CEBPA HHEX KIT RUNX1 RUNX1T1
3 cellular MP:0005384 9.88 CEBPA FLT3 HHEX KIT RUNX1
4 endocrine/exocrine gland MP:0005379 9.85 CEBPA FLT3 HHEX KIT RUNX1
5 hematopoietic system MP:0005397 9.8 CEBPA FLT3 HHEX KIT RUNX1
6 immune system MP:0005387 9.77 CEBPA FLT3 HHEX KIT RUNX1
7 mortality/aging MP:0010768 9.73 CEBPA FLT3 HHEX KIT RUNX1 RUNX1T1
8 liver/biliary system MP:0005370 9.62 CEBPA HHEX KIT RUNX1
9 neoplasm MP:0002006 9.46 CEBPA FLT3 KIT RUNX1
10 no phenotypic analysis MP:0003012 9.26 CEBPA FLT3 KIT RUNX1
11 respiratory system MP:0005388 8.92 CEBPA HHEX KIT RUNX1

Drugs & Therapeutics for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Search Clinical Trials , NIH Clinical Center for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Genetic Tests for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Anatomical Context for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

MalaCards organs/tissues related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:

42
Myeloid, Bone, Bone Marrow

Publications for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Articles related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:

# Title Authors Year
1
Overexpression of HHEX in Acute Myeloid Leukemia with t(8;21)(q22;q22) Translocation. ( 29263042 )
2017
2
Giant granulocytic sarcoma of the vagina concurrent with acute myeloid leukemia with t(8;21)(q22;q22) translocation. ( 20830613 )
2010

Variations for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Expression for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Search GEO for disease gene expression data for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation.

Pathways for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

GO Terms for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Biological processes related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.8 CEBPA HHEX RUNX1 RUNX1T1
2 negative regulation of transcription, DNA-templated GO:0045892 9.69 CEBPA HHEX RUNX1T1
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.52 FLT3 KIT
4 cytokine-mediated signaling pathway GO:0019221 9.5 CEBPA FLT3 KIT
5 B cell differentiation GO:0030183 9.48 FLT3 HHEX
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.46 FLT3 KIT
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 FLT3 KIT
8 positive regulation of MAP kinase activity GO:0043406 9.4 FLT3 KIT
9 generation of precursor metabolites and energy GO:0006091 9.37 CEBPA RUNX1T1
10 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.26 FLT3 KIT
11 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.16 CEBPA HHEX
12 myeloid progenitor cell differentiation GO:0002318 8.96 FLT3 KIT
13 hemopoiesis GO:0030097 8.8 FLT3 KIT RUNX1

Molecular functions related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.43 CEBPA HHEX RUNX1
2 protein homodimerization activity GO:0042803 9.26 CEBPA FLT3 HHEX KIT
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 FLT3 KIT
4 transcription regulatory region DNA binding GO:0044212 8.8 CEBPA HHEX RUNX1

Sources for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
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20 FMA
29 GO
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31 HGMD
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33 HPO
34 ICD10
35 ICD10 via Orphanet
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45 MeSH
46 MESH via Orphanet
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58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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