MCID: ACT194
MIFTS: 24

Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

MalaCards integrated aliases for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:

Name: Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation 58
Aml with T(8;21)(q22;q22) Translocation 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C92.0
Orphanet 58 ORPHA102724

Summaries for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

MalaCards based summary : Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation, also known as aml with t(8;21)(q22;q22) translocation, is related to myeloid sarcoma and myeloid leukemia. An important gene associated with Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation is RUNX1 (RUNX Family Transcription Factor 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include myeloid, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Diseases in the Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation family:

Acute Myeloid Leukemia with T(8;16)(p11;p13) Translocation

Diseases related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 myeloid sarcoma 30.2 KIT FLT3
2 myeloid leukemia 28.9 RUNX1T1 RUNX1 KIT FLT3 CEBPA
3 leukemia, acute myeloid 28.8 RUNX1T1 RUNX1 KIT FLT3 CEBPA
4 liver fibroma 10.1 KIT HHEX
5 retroperitoneal hemangiopericytoma 10.0 KIT HHEX
6 b-lymphoblastic leukemia/lymphoma 9.8 KIT CEBPA
7 monocytic leukemia 9.8 RUNX1 FLT3
8 mastocytosis 9.8 KIT FLT3
9 acute myeloblastic leukemia with maturation 9.7 KIT FLT3
10 atypical chronic myeloid leukemia 9.7 RUNX1 FLT3
11 cytogenetically normal acute myeloid leukemia 9.7 FLT3 CEBPA
12 mast cell neoplasm 9.7 KIT FLT3
13 myelodysplastic/myeloproliferative neoplasm 9.7 KIT FLT3
14 leukemia, acute lymphoblastic 3 9.6 RUNX1 FLT3
15 chronic eosinophilic leukemia 9.6 KIT FLT3
16 dedifferentiated liposarcoma 9.6 KIT CEBPA
17 childhood acute myeloid leukemia 9.6 KIT FLT3
18 chronic leukemia 9.5 KIT FLT3
19 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.4 RUNX1 KIT FLT3
20 8p11 myeloproliferative syndrome 9.4 RUNX1 KIT FLT3
21 aggressive systemic mastocytosis 9.4 RUNX1 KIT FLT3
22 blood platelet disease 9.4 RUNX1 KIT FLT3
23 leukocyte disease 9.4 KIT FLT3
24 pancytopenia 9.4 RUNX1 KIT FLT3
25 chronic myelomonocytic leukemia 9.4 RUNX1 KIT FLT3
26 myeloproliferative neoplasm 9.4 RUNX1 KIT FLT3
27 myelofibrosis 9.4 RUNX1 KIT FLT3
28 leukemia, acute lymphoblastic 9.3 RUNX1 KIT FLT3
29 bone marrow cancer 9.2 KIT FLT3
30 wilms tumor 1 9.2 KIT FLT3 CEBPA
31 leukemia, chronic myeloid 9.2 RUNX1 KIT FLT3
32 hematologic cancer 9.0 RUNX1T1 RUNX1 KIT FLT3
33 core binding factor acute myeloid leukemia 9.0 RUNX1 KIT FLT3 CEBPA
34 cebpa-associated familial acute myeloid leukemia 9.0 RUNX1 KIT FLT3 CEBPA
35 acute promyelocytic leukemia 8.9 RUNX1T1 RUNX1 FLT3 CEBPA
36 myelodysplastic syndrome 8.9 RUNX1 KIT FLT3 CEBPA
37 leukemia 8.6 RUNX1T1 RUNX1 KIT FLT3 CEBPA
38 acute leukemia 8.6 RUNX1T1 RUNX1 KIT FLT3 CEBPA

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:



Diseases related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Symptoms & Phenotypes for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

GenomeRNAi Phenotypes related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.26 KIT
2 Decreased substrate adherent cell growth GR00193-A-2 9.26 KIT
3 Decreased substrate adherent cell growth GR00193-A-4 9.26 FLT3 KIT
4 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.32 FLT3

MGI Mouse Phenotypes related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 CEBPA FLT3 HHEX KIT RUNX1 RUNX1T1
2 cardiovascular system MP:0005385 9.88 CEBPA HHEX KIT RUNX1 RUNX1T1
3 hematopoietic system MP:0005397 9.88 CEBPA FLT3 HHEX KIT RUNX1 RUNX1T1
4 endocrine/exocrine gland MP:0005379 9.85 CEBPA FLT3 HHEX KIT RUNX1
5 immune system MP:0005387 9.85 CEBPA FLT3 HHEX KIT RUNX1 RUNX1T1
6 mortality/aging MP:0010768 9.73 CEBPA FLT3 HHEX KIT RUNX1 RUNX1T1
7 liver/biliary system MP:0005370 9.62 CEBPA HHEX KIT RUNX1
8 neoplasm MP:0002006 9.46 CEBPA FLT3 KIT RUNX1
9 no phenotypic analysis MP:0003012 9.26 CEBPA FLT3 KIT RUNX1
10 respiratory system MP:0005388 8.92 CEBPA HHEX KIT RUNX1

Drugs & Therapeutics for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Search Clinical Trials , NIH Clinical Center for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Genetic Tests for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Anatomical Context for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

MalaCards organs/tissues related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:

40
Myeloid

Publications for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Articles related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation:

# Title Authors PMID Year
1
Overexpression of HHEX in Acute Myeloid Leukemia with t(8;21)(q22;q22) Translocation. 61
29263042 2017
2
Importance of c-kit mutation detection method sensitivity in prognostic analyses of t(8;21)(q22;q22) acute myeloid leukemia. 61
21606963 2011
3
Giant granulocytic sarcoma of the vagina concurrent with acute myeloid leukemia with t(8;21)(q22;q22) translocation. 61
20830613 2010
4
Prognostic value of real-time quantitative PCR (RQ-PCR) in AML with t(8;21). 61
15674426 2005

Variations for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Expression for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Search GEO for disease gene expression data for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation.

Pathways for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

GO Terms for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

Biological processes related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.84 RUNX1T1 RUNX1 HHEX CEBPA
2 multicellular organism development GO:0007275 9.73 KIT HHEX FLT3 CEBPA
3 negative regulation of transcription, DNA-templated GO:0045892 9.72 RUNX1T1 HHEX CEBPA
4 cytokine-mediated signaling pathway GO:0019221 9.54 KIT FLT3 CEBPA
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.52 KIT FLT3
6 positive regulation of kinase activity GO:0033674 9.51 KIT FLT3
7 hematopoietic progenitor cell differentiation GO:0002244 9.49 KIT FLT3
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.48 KIT FLT3
9 positive regulation of MAP kinase activity GO:0043406 9.46 KIT FLT3
10 generation of precursor metabolites and energy GO:0006091 9.4 RUNX1T1 CEBPA
11 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.32 HHEX CEBPA
12 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.26 KIT FLT3
13 myeloid progenitor cell differentiation GO:0002318 9.16 KIT FLT3
14 B cell differentiation GO:0030183 9.13 KIT HHEX FLT3
15 hemopoiesis GO:0030097 8.8 RUNX1 KIT FLT3

Molecular functions related to Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.26 KIT FLT3
2 growth factor binding GO:0019838 9.16 KIT FLT3
3 transcription regulatory region sequence-specific DNA binding GO:0000976 9.13 RUNX1 HHEX CEBPA
4 transcription regulatory region DNA binding GO:0044212 8.8 RUNX1 HHEX CEBPA

Sources for Acute Myeloid Leukemia with T(8;21)(q22;q22) Translocation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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