MCID: ACT195
MIFTS: 16

Acute Myeloid Leukemia with T(9;11)(p22;q23)

Categories: Blood diseases, Cancer diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Myeloid Leukemia with T(9;11)(p22;q23)

MalaCards integrated aliases for Acute Myeloid Leukemia with T(9;11)(p22;q23):

Name: Acute Myeloid Leukemia with T(9;11)(p22;q23) 58
Aml with T(9;11)(p22;q23) 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C92.0
Orphanet 58 ORPHA402017

Summaries for Acute Myeloid Leukemia with T(9;11)(p22;q23)

MalaCards based summary : Acute Myeloid Leukemia with T(9;11)(p22;q23), also known as aml with t(9;11)(p22;q23), is related to leukemia, acute myeloid and myeloid leukemia. An important gene associated with Acute Myeloid Leukemia with T(9;11)(p22;q23) is KMT2A (Lysine Methyltransferase 2A), and among its related pathways/superpathways is Transcriptional misregulation in cancer. Affiliated tissues include myeloid and monocytes.

Related Diseases for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Diseases in the Myeloid Leukemia family:

Leukemia, Acute Myeloid Leukemia, Chronic Myeloid
Subacute Myeloid Leukemia Acute Myeloid Leukemia with T(9;11)(p22;q23)
Acute Myeloid Leukemia with T(6;9)(p23;q34)

Diseases related to Acute Myeloid Leukemia with T(9;11)(p22;q23) via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 10.7
2 myeloid leukemia 10.7
3 langerhans cell histiocytosis 10.5
4 leukemia 10.5
5 histiocytosis 10.5
6 acute monoblastic leukemia 10.5
7 myeloid sarcoma 10.5
8 chromosomal triplication 10.5
9 leukemia, acute monocytic 9.6 MLLT3 KMT2A
10 childhood leukemia 9.5 MLLT3 KMT2A
11 monocytic leukemia 9.5 MLLT3 KMT2A
12 acute leukemia 9.4 MLLT3 KMT2A
13 leukemia, acute lymphoblastic 9.2 MLLT3 KMT2A

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with T(9;11)(p22;q23):



Diseases related to Acute Myeloid Leukemia with T(9;11)(p22;q23)

Symptoms & Phenotypes for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Drugs & Therapeutics for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Search Clinical Trials , NIH Clinical Center for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Genetic Tests for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Anatomical Context for Acute Myeloid Leukemia with T(9;11)(p22;q23)

MalaCards organs/tissues related to Acute Myeloid Leukemia with T(9;11)(p22;q23):

40
Myeloid, Monocytes

Publications for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Articles related to Acute Myeloid Leukemia with T(9;11)(p22;q23):

# Title Authors PMID Year
1
Prognostic factors of childhood and adolescent acute myeloid leukemia (AML) survival: evidence from four decades of US population data. 61
26159683 2015
2
Acute myeloid leukemia with t(9;11) (p22;q23) and synchronous Langerhans cell histiocytosis. 61
23667134 2014
3
Congenital leukemia cutis preceding acute myeloid leukemia with t(9;11)(p22;q23), MLL-MLLT3. 61
23594338 2013
4
Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias: a study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group. 61
23008312 2013
5
High IGSF4 expression in pediatric M5 acute myeloid leukemia with t(9;11)(p22;q23). 61
21045196 2011
6
CKIT mutation in therapy-related acute myeloid leukemia with MLLT3/MLL chimeric transcript from t(9;11)(p22;q23). 61
21844580 2011
7
High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome. 61
20861917 2010
8
Extramedullary relapse of AML with t(9;11)(p22;q23) associated with clonal evolution from trisomy 8 into tetrasomy 8. 61
20190481 2010

Variations for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Expression for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Search GEO for disease gene expression data for Acute Myeloid Leukemia with T(9;11)(p22;q23).

Pathways for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Pathways related to Acute Myeloid Leukemia with T(9;11)(p22;q23) according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.89 MLLT3 KMT2A

GO Terms for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Biological processes related to Acute Myeloid Leukemia with T(9;11)(p22;q23) according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 8.62 MLLT3 KMT2A

Molecular functions related to Acute Myeloid Leukemia with T(9;11)(p22;q23) according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysine-acetylated histone binding GO:0070577 8.62 MLLT3 KMT2A

Sources for Acute Myeloid Leukemia with T(9;11)(p22;q23)

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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