MCID: ACT195
MIFTS: 24

Acute Myeloid Leukemia with T(9;11)(p22;q23)

Categories: Blood diseases, Rare diseases, Cancer diseases, Genetic diseases, Immune diseases

Aliases & Classifications for Acute Myeloid Leukemia with T(9;11)(p22;q23)

MalaCards integrated aliases for Acute Myeloid Leukemia with T(9;11)(p22;q23):

Name: Acute Myeloid Leukemia with T(9;11)(p22;q23) 59
Aml with T(9;11)(p22;q23) 59

Classifications:



External Ids:

Orphanet 59 ORPHA402017
ICD10 via Orphanet 34 C92.0

Summaries for Acute Myeloid Leukemia with T(9;11)(p22;q23)

MalaCards based summary : Acute Myeloid Leukemia with T(9;11)(p22;q23), also known as aml with t(9;11)(p22;q23), is related to leukemia, acute myeloid and leukemia. An important gene associated with Acute Myeloid Leukemia with T(9;11)(p22;q23) is MLLT3 (MLLT3, Super Elongation Complex Subunit), and among its related pathways/superpathways is Transcriptional misregulation in cancer. The drugs Lenalidomide and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include myeloid.

Related Diseases for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Diseases in the Myeloid Leukemia family:

Leukemia, Acute Myeloid Leukemia, Chronic Myeloid
Acute Myeloid Leukemia with T(9;11)(p22;q23) Acute Myeloid Leukemia with T(6;9)(p23;q34)

Diseases related to Acute Myeloid Leukemia with T(9;11)(p22;q23) via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 29.2 KMT2A MLLT3
2 leukemia 10.5
3 myeloid leukemia 10.5
4 langerhans cell histiocytosis 10.3
5 histiocytosis 10.3
6 leukemia, acute monocytic 9.4 KMT2A MLLT3
7 childhood leukemia 9.3 KMT2A MLLT3
8 acute leukemia 9.2 KMT2A MLLT3

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with T(9;11)(p22;q23):



Diseases related to Acute Myeloid Leukemia with T(9;11)(p22;q23)

Symptoms & Phenotypes for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Drugs & Therapeutics for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Drugs for Acute Myeloid Leukemia with T(9;11)(p22;q23) (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenalidomide Approved Phase 1, Phase 2 191732-72-6 216326
2
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
3
Cytarabine Approved, Investigational Phase 2,Phase 1 147-94-4 6253
4
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
5
Everolimus Approved Phase 2 159351-69-6 6442177
6
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
7
Mycophenolic acid Approved Phase 2 24280-93-1 446541
8
Mycophenolate mofetil Approved, Investigational Phase 2 128794-94-5 5281078
9
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
10
Azacitidine Approved, Investigational Phase 2,Phase 1 320-67-2 9444
11
tipifarnib Investigational Phase 2,Phase 1 192185-72-1 159324
12
Entinostat Investigational Phase 2 209783-80-2
13 Angiogenesis Inhibitors Phase 1, Phase 2
14 Angiogenesis Modulating Agents Phase 1, Phase 2
15 Anti-Bacterial Agents Phase 1, Phase 2,Phase 2
16 Immunosuppressive Agents Phase 1, Phase 2,Phase 2
17 Anti-Infective Agents Phase 1, Phase 2,Phase 2
18 Histone Deacetylase Inhibitors Phase 2,Phase 1
19 Vidarabine Phosphate Phase 2
20 Antibiotics, Antitubercular Phase 2,Phase 1
21 Antifungal Agents Phase 2
22 Antitubercular Agents Phase 2
23 Antimetabolites Phase 2,Phase 1
24 Antiviral Agents Phase 2,Phase 1
25 Antimetabolites, Antineoplastic Phase 2,Phase 1
26 Calcineurin Inhibitors Phase 2
27
Sorafenib Approved, Investigational Phase 1 284461-73-0 216239 406563
28
Idarubicin Approved Phase 1 58957-92-9 42890
29
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
30
Belinostat Approved, Investigational Phase 1 866323-14-0
31
Etoposide Approved Phase 1 33419-42-0 36462
32
Mitoxantrone Approved, Investigational Phase 1 65271-80-9 4212
33
Nicotinamide Approved, Investigational, Nutraceutical Phase 1 98-92-0 936
34
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
36 Micronutrients Phase 1
37 Nicotinic Acids Phase 1
38 Topoisomerase Inhibitors Phase 1
39 Trace Elements Phase 1
40 Vitamin B Complex Phase 1
41 Vitamins Phase 1
42 Protein Kinase Inhibitors Phase 1
43 Podophyllotoxin Phase 1 518-28-5
44 Analgesics Phase 1
45 Dermatologic Agents Phase 1
46 Peripheral Nervous System Agents Phase 1
47 Etoposide phosphate Phase 1
48 Keratolytic Agents Phase 1
49 Antimitotic Agents Phase 1
50 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant Unknown status NCT02038153 Phase 1, Phase 2 Lenalidomide
2 Cytarabine With or Without SCH 900776 in Treating Adult Patients With Relapsed Acute Myeloid Leukemia Completed NCT01870596 Phase 2 Cytarabine;CHK1 Inhibitor SCH 900776
3 Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia Completed NCT01361464 Phase 2 Tipifarnib
4 Azacitidine With or Without Entinostat in Treating Patients With Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Completed NCT00313586 Phase 2 Azacitidine;Entinostat
5 Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00105001 Phase 2 Fludarabine Phosphate;Tacrolimus;Mycophenolate Mofetil;Sirolimus
6 Lenalidomide, Cytarabine, and Idarubicin in Treating Patients With Acute Myeloid Leukemia Completed NCT01132586 Phase 1 Lenalidomide;Cytarabine;Idarubicin
7 Belinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases Completed NCT00351975 Phase 1 Belinostat;Azacitidine
8 Tipifarnib and Bortezomib in Treating Patients With Acute Leukemia or Chronic Myelogenous Leukemia in Blast Phase Completed NCT00383474 Phase 1 Bortezomib;Tipifarnib
9 Sorafenib in Treating Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndromes, or Blastic Phase Chronic Myelogenous Leukemia Completed NCT00217646 Phase 1 Sorafenib Tosylate
10 Azacitidine, Mitoxantrone Hydrochloride, and Etoposide in Treating Older Patients With Poor-Prognosis Acute Myeloid Leukemia Terminated NCT01260714 Phase 1 Azacitidine;Etoposide;Mitoxantrone Hydrochloride

Search NIH Clinical Center for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Genetic Tests for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Anatomical Context for Acute Myeloid Leukemia with T(9;11)(p22;q23)

MalaCards organs/tissues related to Acute Myeloid Leukemia with T(9;11)(p22;q23):

41
Myeloid

Publications for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Articles related to Acute Myeloid Leukemia with T(9;11)(p22;q23):

# Title Authors Year
1
Acute Myeloid Leukemia With t(9;11)(p22;q23) and Synchronous Langerhans Cell Histiocytosis. ( 23667134 )
2013
2
High IGSF4 expression in pediatric M5 acute myeloid leukemia with t(9;11)(p22;q23). ( 21045196 )
2011

Variations for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Expression for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Search GEO for disease gene expression data for Acute Myeloid Leukemia with T(9;11)(p22;q23).

Pathways for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Pathways related to Acute Myeloid Leukemia with T(9;11)(p22;q23) according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.89 KMT2A MLLT3

GO Terms for Acute Myeloid Leukemia with T(9;11)(p22;q23)

Biological processes related to Acute Myeloid Leukemia with T(9;11)(p22;q23) according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 8.62 KMT2A MLLT3

Molecular functions related to Acute Myeloid Leukemia with T(9;11)(p22;q23) according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 8.96 KMT2A MLLT3
2 lysine-acetylated histone binding GO:0070577 8.62 KMT2A MLLT3

Sources for Acute Myeloid Leukemia with T(9;11)(p22;q23)

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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