MCID: ACT075
MIFTS: 59

Acute Myocardial Infarction

Categories: Cardiovascular diseases, Genetic diseases
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Aliases & Classifications for Acute Myocardial Infarction

MalaCards integrated aliases for Acute Myocardial Infarction:

Name: Acute Myocardial Infarction 11 53 5 14 16 71 31 33
Cardiac Attack 33
Heart Attack 33

Classifications:



External Ids:

Disease Ontology 11 DOID:9408
ICD9CM 34 410
NCIt 49 C35204
SNOMED-CT 68 155304006
ICD10 31 I21 I21.9
UMLS 71 C0155626

Summaries for Acute Myocardial Infarction

MalaCards based summary: Acute Myocardial Infarction, also known as cardiac attack, is related to cardiogenic shock and angina pectoris, and has symptoms including angina pectoris and chest pain. An important gene associated with Acute Myocardial Infarction is MIR208B (MicroRNA 208b), and among its related pathways/superpathways is Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Colchicine and Dabigatran have been mentioned in the context of this disorder. Affiliated tissues include heart, bone marrow and bone, and related phenotypes are muscle and cardiovascular system

Related Diseases for Acute Myocardial Infarction

Diseases in the Myocardial Infarction family:

Myocardial Infarction 2 Posterior Myocardial Infarction
Acute Myocardial Infarction

Diseases related to Acute Myocardial Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1217)
# Related Disease Score Top Affiliating Genes
1 cardiogenic shock 33.1 PLAT PIK3C2A NPPB
2 angina pectoris 32.9 TNNI3 PLAT PIK3C2A NPPB MB F3
3 acute anterolateral myocardial infarction 32.8 PIK3C2A NPPB CRP ACE
4 intermediate coronary syndrome 32.7 TNNT2 TNNI3 NPPB MIR499A MB F3
5 myocardial infarction 32.5 TNNT2 TNNI3 PLAT PIK3C2A NPPB MIR499A
6 cardiac arrest 32.4 TNNT2 TNNI3 NPPB MIR499A MB FABP3
7 congestive heart failure 32.4 TNNT2 TNNI3 NPPB FABP3 CDKN2B-AS1 ACE
8 atrioventricular block 32.4 TNNT2 TNNI3 PIK3C2A NPPB CRP ACE
9 left bundle branch hemiblock 32.4 TNNT2 TNNI3 NPPB CRP ACE
10 third-degree atrioventricular block 32.3 TNNI3 NPPB CRP ACE
11 mitral valve insufficiency 32.3 TNNT2 TNNI3 NPPB F3 CRP ACE
12 coronary stenosis 32.3 TNNI3 PIK3C2A NPPB CRP ACE
13 coronary thrombosis 32.3 TNNI3 PLAT MIR499A F3 CRP
14 atrial fibrillation 32.3 TNNI3 PLAT NPPB F3 CRP ACE
15 inferior myocardial infarction 32.3 TNNT2 TNNI3 PLAT PIK3C2A NPPB ACE
16 pulmonary edema 32.2 TNNT2 TNNI3 PIK3C2A NPPB CRP ACE
17 pericarditis 32.2 TNNT2 TNNI3 NPPB CRP ACE
18 heart septal defect 32.2 TNNT2 NPPB MIR499A F3 CRP
19 coronary artery vasospasm 32.2 TNNT2 TNNI3 PIK3C2A NPPB MB F3
20 myocarditis 32.2 TNNT2 TNNI3 PIK3C2A NPPB MB F3
21 hypokalemia 32.2 PIK3C2A MB ACE
22 chronic kidney disease 32.1 TNNT2 TNNI3 NPPB CRP ACE
23 peripheral vascular disease 32.1 PLAT F3 CRP ACE
24 right bundle branch block 32.1 TNNT2 TNNI3 NPPB CRP ACE
25 stroke, ischemic 32.0 PLAT NPPB MB F3 CRP CDKN2B-AS1
26 aortic dissection 32.0 TNNT2 CRP ACE
27 pericardial effusion 32.0 TNNT2 TNNI3 PIK3C2A NPPB MB F3
28 ventricular septal defect 32.0 TNNT2 NPPB MIR499A
29 cardiac tamponade 32.0 TNNI3 PLAT PIK3C2A NPPB F3 CRP
30 ischemia 32.0 TNNT2 PLAT PIK3C2A NPPB MB FABP3
31 respiratory failure 31.9 TNNI3 PIK3C2A NPPB MB F3 CRP
32 pulmonary embolism 31.9 TNNT2 TNNI3 PLAT NPPB MB FABP3
33 pulmonary disease, chronic obstructive 31.9 NPPB MB CRP ACE
34 acute kidney failure 31.9 PIK3C2A MB ACE
35 antiphospholipid syndrome 31.9 PLAT F3 CRP
36 sleep apnea 31.8 NPPB CRP ACE
37 transient cerebral ischemia 31.8 PLAT NPPB F3 CRP ACE
38 anteroseptal myocardial infarction 31.8 PIK3C2A MB ACE
39 endocarditis 31.8 TNNT2 TNNI3 PLAT PIK3C2A CRP
40 anterolateral myocardial infarction 31.8 PLAT NPPB ACE
41 hemopericardium 31.8 TNNI3 PLAT NPPB F3 CRP
42 acute myocarditis 31.8 TNNT2 TNNI3 NPPB MIR499A CRP ACE
43 apnea, obstructive sleep 31.7 NPPB CRP ACE
44 coronary aneurysm 31.7 NPPB F3 CRP ACE
45 infective endocarditis 31.7 NPPB F3 CRP ACE
46 heart disease 31.7 TNNT2 TNNI3 PLAT PIK3C2A NPPB MIR499A
47 myocardial stunning 31.7 TNNT2 TNNI3 NPPB ACE
48 hypothyroidism 31.7 PIK3C2A NPPB F3 CRP ACE
49 lipoprotein quantitative trait locus 31.7 TNNT2 TNNI3 PLAT PIK3C2A NPPB MIR499A
50 atherosclerosis susceptibility 31.7 PLAT F3 CRP CDKN2B-AS1 ACE

Comorbidity relations with Acute Myocardial Infarction via Phenotypic Disease Network (PDN): (show all 20)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Aortic Valve Disease 1
Cardiac Arrest Chronic Kidney Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Kidney Disease
Mitral Valve Disease Peripheral Vascular Disease
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Acute Myocardial Infarction:



Diseases related to Acute Myocardial Infarction

Symptoms & Phenotypes for Acute Myocardial Infarction

UMLS symptoms related to Acute Myocardial Infarction:


angina pectoris; chest pain

MGI Mouse Phenotypes related to Acute Myocardial Infarction:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.61 F3 FABP3 MB MIR208B MIR499A NPPB
2 cardiovascular system MP:0005385 9.36 ACE CRP F3 FABP3 IDH2 MB

Drugs & Therapeutics for Acute Myocardial Infarction

Drugs for Acute Myocardial Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 346)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Colchicine Approved Phase 4 64-86-8 2833 6167
2
Dabigatran Approved, Investigational Phase 4 211914-51-1 216210
3
Streptokinase Approved, Investigational Phase 4 9002-01-1
4
Insulin glargine Approved Phase 4 160337-95-1 118984454
5
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
6
Tannic acid Approved Phase 4 1401-55-4 16129878 16129778
7
Abciximab Approved Phase 4 143653-53-6 3815015
8
Lenograstim Approved, Investigational Phase 4 135968-09-1
9
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
10
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
11
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
12
Verapamil Approved Phase 4 152-11-4, 52-53-9 2520
13
Tirofiban Approved Phase 4 144494-65-5 60947
14
Reteplase Approved, Investigational Phase 4 133652-38-7
15
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
16
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
17
Reviparin Approved, Investigational Phase 4 9041-08-1
18
Eplerenone Approved Phase 4 107724-20-9 443872
19
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
20
Insulin lispro Approved Phase 4 133107-64-9 16132438
21
Zinc cation Approved, Experimental, Investigational Phase 4 7440-66-6, 23713-49-7 32051
22 Apricot Approved Phase 4
23
Aminophylline Approved Phase 4 317-34-0 9433
24
Edaravone Approved, Investigational Phase 4 89-25-8 4021 70335
25
Acetylcysteine Approved, Investigational Phase 4 616-91-1 581 12035
26
Esomeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6, 119141-88-7 9568614 4594
27
Famotidine Approved Phase 4 76824-35-6 3325 5702160
28
Histamine Approved, Investigational Phase 4 51-45-6 774
29
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
30
Evolocumab Approved Phase 4 1256937-27-5
31
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
32
Cangrelor Approved Phase 4 163706-06-7 9854012
33
Pitavastatin Approved Phase 4 147511-69-1 5282452
34
Atenolol Approved Phase 4 29122-68-7 2249
35
Ezetimibe Approved Phase 4 163222-33-1 150311
36
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
37
Bisoprolol Approved Phase 4 66722-44-9 2405
38
Warfarin Approved Phase 4 81-81-2, 129-06-6 54678486
39
Rivaroxaban Approved Phase 4 366789-02-8 9875401
40
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
41
Everolimus Approved Phase 4 159351-69-6 70789204 6442177
42
Cobalt Approved, Experimental, Withdrawn Phase 4 7440-48-4 104729
43
Chromium Approved Phase 4 7440-47-3 27668
44
Acetylsalicylic acid Approved, Vet_approved Phase 4 50-78-2 2244
45
Norepinephrine Approved Phase 4 51-41-2 439260
46
Dapagliflozin Approved Phase 4 461432-26-8 9887712
47
Nicorandil Approved, Investigational Phase 4 65141-46-0 47528
48
Ticagrelor Approved Phase 4 274693-27-5 9871419
49
Heparin, bovine Approved, Investigational, Withdrawn Phase 4 9005-49-6 22833565 9812414 772
50
Tenecteplase Approved Phase 4 191588-94-0

Interventional clinical trials:

(show top 50) (show all 862)
# Name Status NCT ID Phase Drugs
1 Pravastatin for Acute Myocardial Infarction With Minimally to Mildly Increased Levels of Serum Cholesterol Study That Evaluates the Effects of Pravastatin for Acute Myocardial Infarction With LDL-Cholesterol Levels of 70-129 mg/dl Unknown status NCT00688922 Phase 4 Pravastatin
2 Role of Innate and Adaptive Immunity After Acute Myocardial Infarction BATTLE-AMI Study (B And T Types of Lymphocytes Evaluation in Acute Myocardial Infarction) Unknown status NCT02428374 Phase 4 Rosuvastatin plus clopidogrel;Rosuvastatin plus ticagrelor;Simvastatin plus clopidogrel;Simvastatin plus ticagrelor
3 A Randomized Clinical Trial Comparing Primary PCI and Post-thrombolysis PCI as Reperfusion Strategies in Patients With ST Segment Elevation Acute Myocardial Infarction Unknown status NCT02268669 Phase 4
4 Erythropoietin Prevention Trial of Coronary Restenosis and Cardiac Remodeling After Acute Myocardial Infarction (EPOC-AMI) Unknown status NCT00423020 Phase 4 Erythropoietin
5 China Tongxinluo Study for Myocardial Protection in Patients With Acute Myocardial Infarction Unknown status NCT03792035 Phase 4 Tongxinluo;Placebos
6 Adjunctive Cilostazol to Dual Antiplatelet Therapy to Enhance Mobilization of Endothelial Progenitor Cell in Patients With Acute Myocardial Infarction: A Randomized, Placebo-controlled ACCEL-EPISODE Trial Unknown status NCT04407312 Phase 4 Cilostazol Tablets;placebo;Aspirin;Clopidogrel
7 Multicentre 2x2 Factorial Randomised Study Comparing Tirofiban Administered With the Single High-Dose Bolus Versus Abciximab and Sirolimus Eluting Stent Versus Bare Metal Stent in Acute Myocardial Infarction - MULTI-STRATEGY Trial Unknown status NCT00229515 Phase 4
8 Randomized Study Of Sirolimus Eluting Stent Vs Conventional Stent In Acute Myocardial Infarction Acronym SESAMI Unknown status NCT00288210 Phase 4
9 A Multi-center Study on the Optimized Antithrombotic Therapy of Acute Myocardial Infarction With Left Ventricular Mural Thrombus. Unknown status NCT03415386 Phase 4 Combination of antiplatelet drugs and anticoagulants for at least one month
10 Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction Unknown status NCT02512978 Phase 4 Levothyroxine
11 Randomized, Prospective , Open Label, Phase 4 Trial of Efficacy and Safety of Adjunctive Cilostazol in Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention With Drug-eluting Stent Unknown status NCT01261832 Phase 4 antiplatelet therapy
12 Microvascular Reperfusion Utilizing Sonothrombolysis in Acute Myocardial Infarction (MRUSMI TRIAL) Unknown status NCT02170103 Phase 4 Microbubbles
13 Efficacy of Thrombosuction in Primary Percutaneous Coronary Intervention of Acute Myocardial Infarction Unknown status NCT01156662 Phase 4
14 Dissecting the Role of Distal Embolization of Athero-thrombotic Material in Primary PCI: the ThrombOticBurden and mIcrovAscularobStruction (TOBIAS) Study. Unknown status NCT01914055 Phase 4
15 Effect of Gradual Reperfusion on Myocardial Edema and Coronary Microvascular Integrity in Patients Undergoing Primary Percutaneous Coronary Intervention Unknown status NCT02732080 Phase 4
16 Prospective RandomizEd Study Comparing Glycoprotein IIb/IIIa Inhibitors VERsus Standard Therapy in patientS With Myocardial Infarction and Angiographic Evidence of No-reFLOW Unknown status NCT02739711 Phase 4 Glycoprotein IIb/IIIa inhibitors
17 Study of Anti-inflammatory Treatment With Colchicine in the Acute Phase of ST-elevation Myocardial Infarction to Reduce Infarct Size Unknown status NCT01936285 Phase 4 Colchicine 2 mg loading dose; 0.5 mg bid for 5 days;Placebo
18 N-3 Fatty Acids for the Prevention of Atrial Fibrillation in Patients With Acute Heart Failure Unknown status NCT00692718 Phase 4 Epadel, Eicosapentaenoic acid
19 Imaging of Inflammation in the Postischemic Myocardium: Effect of Anti-inflammatory Treatment With Colchicine Unknown status NCT02281305 Phase 4 Colchicine
20 Evaluation of Neointimal Coverage of Everolimus-Eluting Stent and Bare-metal Stent After Implantation in STEMI Patients by Optical Coherence Tomography Unknown status NCT01875835 Phase 4
21 Randomized Controlled Study of a Rapid "Rule Out" Strategy Using CT Coronary Angiogram Versus Traditional Care for Low- to Intermediate-Risk ED Patients With Potential Acute Coronary Syndromes Unknown status NCT00933400 Phase 4
22 Effects of Sodium Tanshinone IIA Sulfonate on Left Ventricular Remodeling in Patients With ST-segment Elevation Myocardial Infarction Following Percutaneous Coronary Intervention Unknown status NCT02524964 Phase 4 sodium tanshinone IIA sulfonate
23 Treating Acute MI Patients With Aggrastat on Their Way to Hospital Unknown status NCT00300833 Phase 4 Tirofiban
24 The Effect of Tongguan Capsule for MicroRNA Profiles Between Qi-Stagnation and Qi-Deficiency in Coronary Heart Disease Patients With Blood Stasis Syndrome Undergoing Percutaneous Coronary Intervention Unknown status NCT02850627 Phase 4 Tongguan capsule;placebo capsule
25 A Prospective, Multicenter, Randomized, Open-label Trial to Compare Efficacy and Safety of Clopidogrel vs Ticagrelor in Stabilized Patients With Acute Myocardial Infarction After Percutaneous Coronary Intervention; TicAgrelor Versus CLOpidogrel in Stabilized Patients With Acute Myocardial Infarction: TALOS-AMI Completed NCT02018055 Phase 4 Aspirin+Ticagrelor;Aspirin+Clopidogrel
26 Phase 4 Study of Application of Intracoronary Low Dose Streptokinase Complementary to Standard Percutaneous Coronary Intervention in Patients With ST Elevation Acute Myocardial Infarction: Effect of Adjunctive Intracoronary Streptokinase on Late Term Left Ventricular Infarct Size and Volumes in Patients With Acute Myocardial Infarction Completed NCT00627809 Phase 4 Streptokinase
27 Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The ME"Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion" (METOCARD-CNIC): A Randomized, Controlled Parallel-group, Observer-blinded Clinical Trial of Early Pre-reperfusion Metoprolol Administration in ST-segment Elevation Myocardial infarctionTOCARD-CNIC Trial. Completed NCT01311700 Phase 4 Injectable (i.v.) metoprolol tartrate (up to 15 mg).
28 Tight Glycemic Control Increases Cardiac Stem Cells and Reduces Heart Remodeling During Acute Myocardial Infarction in Hyperglycemic Patients Completed NCT00863629 Phase 4 Insulin
29 Efficacy of Clotinab in Acute Myocardial Infarction Trial- ST Elevation Myocardial Infarction Completed NCT00841438 Phase 4 Clotinab
30 A Randomized Trial of Early Discharge After Trans-radial Stenting of Coronary Arteries in Acute Myocardial Infarction: The EASY-MI Pilot Study. Completed NCT00440778 Phase 4 Abciximab
31 Early Effect Of Bezafibrate On Fibrinogen Levels, Inflammatory Response And Clinical Impact, In Patients With ST Elevation Acute Myocardial Infarction Completed NCT02291796 Phase 4 Bezafibrate
32 Impact of Morphine Treatment on Platelet Inhibition in Acute Myocardial Infarction Completed NCT02627950 Phase 4 Morphinhydrochloricum;Metoclopramide;Ticagrelor;Isotonic sodium chloride
33 An International, Multicenter, Randomized Trial Assessing the Value of Mechanical Reperfusion in Patients With Acute Myocardial Infarction Presenting > 12 Hours From Onset of Symptoms Completed NCT00759629 Phase 4
34 Randomized Clinical Study of Intraaortic Balloon Pump Use in Cardiogenic Shock Complicating Acute Myocardial Infarction Completed NCT00491036 Phase 4
35 Prospective Randomized Multicenter Study Comparing Immediate Multivessel Revascularization by PCI Versus Culprit Lesion PCI With Staged Non-culprit Lesion Revascularization in Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock Completed NCT01927549 Phase 4
36 Bivalirudin in Acute Myocardial Infarction vs Glycoprotein IIb/IIIa and Heparin Undergoing Angioplasty (BRIGHT):a Randomised Controlled Trial Completed NCT01696110 Phase 4 Bivalirudin;heparin;heparin plus tirofiban
37 Efficacy and Safety of Individualized P2Y12 Receptor Antagonists Treatment Based on Agregometry Versus Fixed Dose Regimen in Patients After Acute Myocardial Infarction Completed NCT04369534 Phase 4 Clopidogrel;Ticagrelor
38 A Multi-center, Randomized, Controlled Study of Mechanical Left Ventricular Unloading With Counterpulsation to Reduce Infarct Size Pre-PCI for Acute Myocardial Infarction - CRISP AMI Completed NCT00833612 Phase 4
39 The Contrast Media and Nephrotoxicity Following Coronary Revascularization by Primary Angioplasty for Acute Myocardial Infarction. The CONTRAST-AMI Study. Completed NCT00827788 Phase 4 Iodixanol;Iopromide
40 Comparison of Administration of Tirofiban in the Ambulance or in the Cathlab in Patients With Acute Myocardial Infarction Treated With Primary Angioplasty Completed NCT00538317 Phase 4 tirofiban
41 Reversal of No-reflow/Slow-flow During Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction--a Prospective Randomized Study Comparing Intracoronary Infusion of Diltiazem, Verapamil and Nitroglycerin Completed NCT00712894 Phase 4 Diltiazem;Verapamil;Nitroglycerin
42 A Randomized Trial of Early Discharge After Trans-Radial Stenting of Coronary Arteries in Acute Myocardial Infarction and RESCUE-PCI: The EASY-RESCUE Pilot Study Completed NCT00440895 Phase 4 Abciximab
43 Comparison of Prasugrel and Ticagrelor in the Treatment of Acute Myocardial Infarction Completed NCT02808767 Phase 4 Prasugrel;Ticagrelor
44 Global Left Ventricular Function After Acute Myocardial Infarction. Treatment With the Angiotensin 2-Receptor Blocker Irbesartan Completed NCT00125645 Phase 4 Irbesartan Oral Tablet
45 Effects of Early Statin Treatment on Symptomatic Heart Failure and Ischemic Events After Acute Myocardial Infarction. The MUSASHI-AMI: A Multicenter Randomized Controlled Trial Completed NCT00128024 Phase 4 lipid-lowering treatment
46 The Effects of Eplerenone on Left Ventricular Remodelling Post-Acute Myocardial Infarction: a Double-Blind Placebo-Controlled Cardiac MR-Based Study Completed NCT00132093 Phase 4 Eplerenone
47 Phase 4 Study of the Effect of Human Recombinant Erythropoietin at the Time of Reperfusion in Patients With Acute Myocardial Infarction Completed NCT00882466 Phase 4 human recombinant erythropoietin
48 Pharmacokinetics and Pharmacodynamics of Platelet P2Y12 Inhibitors in Patients Undergoing Percutaneous Coronary Intervention (PCI) for Acute Myocardial Infarction: A Pilot Study Completed NCT02376283 Phase 4 Prasugrel;Clopidogrel;ticagrelor
49 Hyperglycemia and Its Effect After Acute Myocardial Infarction on Cardiovascular Outcomes in Patients With Type 2 Diabetes (HEART2D) Completed NCT00191282 Phase 4 Insulin lispro;Human insulin isophane suspension (NPH);Insulin glargine;Human insulin isophane suspension;Human insulin 30/70
50 A Multicenter Randomized Trial in the Prevention of Reocclusion Following Successful Thrombolysis for Suspected Acute Myocardial Infarction: An Invasive Versus a Conservative Strategy Completed NCT00138034 Phase 4

Search NIH Clinical Center for Acute Myocardial Infarction

Genetic Tests for Acute Myocardial Infarction

Anatomical Context for Acute Myocardial Infarction

Organs/tissues related to Acute Myocardial Infarction:

MalaCards : Heart, Bone Marrow, Bone, Endothelial, Kidney, Brain, Neutrophil

Publications for Acute Myocardial Infarction

Articles related to Acute Myocardial Infarction:

(show top 50) (show all 35209)
# Title Authors PMID Year
1
Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease. 46
20921333 2010
2
Changes of matrix metalloproteinase-9 level is associated with left ventricular remodeling following acute myocardial infarction among patients treated with trandolapril, valsartan or both. 53 62
20378999 2010
3
Activation of peripheral blood mononuclear cells and extracellular matrix and inflammatory gene profile in acute myocardial infarction. 53 62
20388121 2010
4
Endothelin-1 release in acute myocardial infarction as a predictor of long-term prognosis and no-reflow assessed by contrast-enhanced magnetic resonance imaging. 53 62
20435200 2010
5
Tissue plasminogen activator antigen predicts medium-term left ventricular end-systolic volume after acute myocardial infarction. 53 62
19662337 2010
6
Left ventricular function and C-reactive protein levels in acute myocardial infarction. 53 62
20346306 2010
7
Point-of-care test of heart-type fatty acid-binding protein for the diagnosis of early acute myocardial infarction. 53 62
20140003 2010
8
[The significance of the changes in expressions of heat shock protein 70 and heme oxygenase-1 in the myocardium in patients died suddenly due to acute myocardial infarction]. 53 62
20170613 2010
9
Circulating p53 and cytochrome c levels in acute myocardial infarction patients. 53 62
19551350 2010
10
Noninvasive assessment of left ventricular filling pressure after acute myocardial infarction: a prospective study of the relative prognostic utility of clinical assessment, echocardiography, and B-type natriuretic peptide. 53 62
20102866 2010
11
Comparison of usefulness of heart-type fatty acid binding protein versus cardiac troponin T for diagnosis of acute myocardial infarction. 53 62
20102882 2010
12
Admission creatine kinase as a prognostic marker in acute myocardial infarction. 53 62
20201171 2009
13
Plasma thrombomodulin activity, tissue factor activity and high levels of circulating procoagulant phospholipid as prognostic factors for acute myocardial infarction. 53 62
19809306 2009
14
The profile of circulating metalloproteinases after PCI in patients with acute myocardial infarction or stable angina. 53 62
19410278 2009
15
TNF-alpha/IL-10 ratio and C-reactive protein as markers of the inflammatory response in CAD-prone North Indian patients with acute myocardial infarction. 53 62
19576194 2009
16
Increased expression of TF on monocytes, but decreased numbers of TF bearing microparticles in blood from patients with acute myocardial infarction. 53 62
19558505 2009
17
The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls. 53 62
19520708 2009
18
The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction. 53 62
19637097 2009
19
[Correlation between serum MMP-2 and MMP-9 in patients with acute myocardial infarction before and after PCI]. 53 62
19664397 2009
20
Conjugation of biomolecules with magnetic protein microspheres for the assay of early biomarkers associated with acute myocardial infarction. 53 62
19555077 2009
21
Carboxylated magnetic microbead-assisted fluoroimmunoassay for early biomarkers of acute myocardial infarction. 53 62
19398193 2009
22
The impact of admission C-reactive protein levels on the development of no-reflow phenomenon after primary PCI in patients with acute myocardial infarction: the role of inflammation. 53 62
18579226 2009
23
Plasma TF activity predicts cardiovascular mortality in patients with acute myocardial infarction. 53 62
19570241 2009
24
Association of C-reactive protein and HIV infection with acute myocardial infarction. 53 62
19387353 2009
25
Expressions of eNOS3 and Ve-cadherin in microvascular endothelium at 7-day of reperfused acute myocardial infarction. 53 62
19519369 2009
26
[An angiographic trial to evaluate the efficacy and safety of tenecteplase in Chinese patients with acute myocardial infarction]. 53 62
19927632 2009
27
Superparamagnetic microsphere-assisted fluoroimmunoassay for rapid assessment of acute myocardial infarction. 53 62
19394809 2009
28
[Study of association of platelet endothelial cell adhesion molecule-1 gene polymorphism with acute myocardial infarction]. 53 62
19570335 2009
29
C-terminal provasopressin (copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMAAL study. 53 62
19346228 2009
30
Human heart-type fatty acid-binding protein for on-site diagnosis of early acute myocardial infarction. 53 62
18571749 2009
31
Levels of serum deoxyribonuclease I activity on admission in patients with acute myocardial infarction can be useful in predicting left ventricular enlargement due to remodeling. 53 62
19304122 2009
32
[Coronary flow and hemorrhagic complications after alteplase and streptokinase administration in patients with acute myocardial infarction]. 53 62
19341228 2009
33
[The relationship between plasma BNP level and the left ventricular dysfunction parameters in patients with acute myocardial infarction and it's value in diagonosing heart failure.]. 53 62
19781144 2009
34
Impact of telmisartan on coronary stenting in patients with acute myocardial infarction compared with enalapril. 53 62
18190989 2009
35
The relationship of plasminogen activator inhibitor-1 levels to the ST deviation pattern of acute myocardial infarction. 53 62
18580060 2009
36
Admission levels of C-reactive protein and plasminogen activator inhibitor-1 in patients with acute myocardial infarction with and without cardiogenic shock or heart failure on admission. 53 62
19246845 2009
37
Factors associated with C-reactive protein at the early stage of acute myocardial infarction in men. 53 62
19130414 2009
38
Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry. 53 62
18997620 2009
39
Acute phase proteins and systolic dysfunction in subjects with acute myocardial infarction. 53 62
18038115 2008
40
[Plasma tissue factor and tissue factor pathway inhibitor levels in acute myocardial infarction patients with no-reflow during percutaneous coronary intervention]. 53 62
19102916 2008
41
Impact of plaque rupture and elevated C-reactive protein on clinical outcome in patients with acute myocardial infarction: an intravascular ultrasound study. 53 62
18762670 2008
42
Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation. 53 62
18810578 2008
43
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. 46
18723672 2008
44
Relationship of sustained brain natriuretic peptide release after reperfused acute myocardial infarction with gated SPECT infarct measurements and its connection with collagen turnover and left ventricular remodeling. 53 62
18761267 2008
45
[Comparative effect of streptokinase and alteplase on electrocardiogram and angiogram signs of myocardial reperfusion in ST segment elevation acute myocardial infarction]. 53 62
19069338 2008
46
Value of blood adipose tissue hormones concentration--adiponectin, resistin and leptin in the prediction of major adverse cardiac events (MACE) in 1-year follow-up after primary percutaneous coronary intervention in ST-segment elevation acute myocardial infarction. 53 62
18766137 2008
47
A close relationship between functional polymorphism in the promoter region of matrix metalloproteinase-9 and acute myocardial infarction. 53 62
17698228 2008
48
[Role of nuclear factor-KappaB in endothelial injury in acute myocardial infarction]. 53 62
18611340 2008
49
Value of brain natriuretic peptide after acute myocardial infarction. 53 62
18524723 2008
50
Late ventricular remodeling in non-reperfused acute myocardial infarction in humans is predicted by angiotensin II type 1 receptor density on blood platelets. 53 62
17651844 2008

Variations for Acute Myocardial Infarction

ClinVar genetic disease variations for Acute Myocardial Infarction:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 IDH2 NM_002168.4(IDH2):c.516G>C (p.Arg172Ser) SNV Risk Factor
375985 rs1057519736 GRCh37: 15:90631837-90631837
GRCh38: 15:90088605-90088605
2 IDH2 NM_002168.4(IDH2):c.515G>T (p.Arg172Met) SNV Risk Factor
375986 rs121913503 GRCh37: 15:90631838-90631838
GRCh38: 15:90088606-90088606
3 IDH2 NM_002168.4(IDH2):c.515G>A (p.Arg172Lys) SNV Risk Factor
375987 rs121913503 GRCh37: 15:90631838-90631838
GRCh38: 15:90088606-90088606
4 IDH2 NM_002168.4(IDH2):c.514A>T (p.Arg172Trp) SNV Risk Factor
376438 rs1057519906 GRCh37: 15:90631839-90631839
GRCh38: 15:90088607-90088607

Copy number variations for Acute Myocardial Infarction from CNVD:

6
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 210497 6 30400000 36600000 Amplification C4B Acute myocardial infarction

Expression for Acute Myocardial Infarction

LifeMap Discovery
Genes differentially expressed in tissues of Acute Myocardial Infarction patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 EGR3 early growth response 3 Blood + 5.52 0.000
2 CXCL8 C-X-C motif chemokine ligand 8 Blood + 3.51 0.004
3 LEP leptin Heart + 3.45 0.011
4 ID1 inhibitor of DNA binding 1 Blood + 3.18 0.007
Search GEO for disease gene expression data for Acute Myocardial Infarction.

Pathways for Acute Myocardial Infarction

Pathways related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.78 TNNT2 TNNI3 FABP3

GO Terms for Acute Myocardial Infarction

Cellular components related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin complex GO:0005861 9.46 TNNT2 TNNI3
2 cardiac myofibril GO:0097512 9.26 TNNT2 TNNI3
3 cardiac Troponin complex GO:1990584 8.92 TNNT2 TNNI3

Biological processes related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transition between fast and slow fiber GO:0014883 8.62 MIR499A MIR208B

Molecular functions related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin C binding GO:0030172 8.92 TNNT2 TNNI3

Sources for Acute Myocardial Infarction

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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