MCID: ACT075
MIFTS: 59

Acute Myocardial Infarction

Categories: Cardiovascular diseases, Genetic diseases

Aliases & Classifications for Acute Myocardial Infarction

MalaCards integrated aliases for Acute Myocardial Infarction:

Name: Acute Myocardial Infarction 12 55 15 17 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:9408
ICD9CM 35 410 410.9 410.90
NCIt 50 C35204
SNOMED-CT 68 57054005
ICD10 33 I21 I21.9
UMLS 72 C0155626

Summaries for Acute Myocardial Infarction

MalaCards based summary : Acute Myocardial Infarction is related to acute anterolateral myocardial infarction and cardiac rupture, and has symptoms including angina pectoris and chest pain. An important gene associated with Acute Myocardial Infarction is MIR499A (MicroRNA 499a), and among its related pathways/superpathways is A-beta Pathways: Plaque Formation and APP Metabolism. The drugs Pravastatin and Insulin glargine have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and testes, and related phenotype is cardiovascular system.

Related Diseases for Acute Myocardial Infarction

Diseases in the Myocardial Infarction family:

Myocardial Infarction 2 Posterior Myocardial Infarction
Acute Myocardial Infarction

Diseases related to Acute Myocardial Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 834)
# Related Disease Score Top Affiliating Genes
1 acute anterolateral myocardial infarction 33.9 PIK3C2A ACE
2 cardiac rupture 33.5 PLAT CRP
3 cardiogenic shock 33.4 PLAT PIK3C2A NPPB
4 angina pectoris 32.8 PLAT PIK3C2A NPPB CRP ACE
5 ischemia 32.8 SELP PLAT MB ACE
6 inferior myocardial infarction 32.7 PLAT PIK3C2A NPPB
7 left bundle branch hemiblock 32.7 TNNI3 NPPB ACE
8 cardiac arrest 32.6 TNNT2 PIK3C2A NPPB ACE
9 myocardial infarction 32.6 TNNT2 TNNI3 SELP PLAT PIK3C2A NPPB
10 anterolateral myocardial infarction 32.6 PLAT NPPB ACE
11 pulmonary edema 32.5 PIK3C2A NPPB CRP ACE
12 myocarditis 32.5 TNNI3 NPPB MB
13 thrombosis 32.4 SELP PLAT F3
14 coronary stenosis 32.3 TNNI3 PIK3C2A NPPB CRP ACE
15 atrial fibrillation 32.3 SELP PLAT NPPB CRP ACE
16 pericardial effusion 32.3 PIK3C2A NPPB CRP
17 intermediate coronary syndrome 32.3 TNNI3 SELP PLAT PIK3C2A MB F3
18 atrial standstill 1 32.3 TNNT2 TNNI3 NPPB ACE
19 cerebrovascular disease 32.2 SELP PLAT CRP ACE
20 vascular disease 32.2 SELP PLAT F3 CRP ACE
21 peripheral vascular disease 32.1 SELP PLAT F3 CRP ACE
22 respiratory failure 32.0 PIK3C2A F3 CRP ACE
23 endocarditis 32.0 TNNI3 PLAT PIK3C2A CRP
24 posterior myocardial infarction 32.0 PLAT PIK3C2A MB
25 antiphospholipid syndrome 32.0 SELP PLAT F3
26 sleep apnea 31.9 NPPB CRP ACE
27 arteries, anomalies of 31.9 TNNI3 SELP PLAT NPPB MB F3
28 pulmonary embolism 31.8 TNNT2 TNNI3 PLAT NPPB FABP3 F3
29 arteriosclerosis 31.7 SELP F3 CRP ACE
30 disseminated intravascular coagulation 31.7 PLAT PIK3C2A MB F3
31 systolic heart failure 31.7 NPPB CRP ACE
32 coronary heart disease 1 31.7 SELP PLAT NPPB CRP CDKN2B-AS1 ACE
33 heart valve disease 31.7 NPPB CRP ACE
34 thrombocytosis 31.6 SELP F3 CRP
35 congestive heart failure 31.6 NPPB MHRT CDKN2B-AS1 ACE
36 coronary artery anomaly 31.6 TNNT2 TNNI3 SELP PLAT PIK3C2A NPPB
37 gas gangrene 31.6 TNNI3 PIK3C2A MB
38 heart disease 31.5 TNNT2 TNNI3 SELP PLAT PIK3C2A NPPB
39 pulmonary hypertension 31.4 PLAT NPPB F3 ACE
40 congenitally corrected transposition of the great arteries 31.3 TNNT2 NPPB
41 platelet aggregation, spontaneous 31.3 SELP PLAT
42 aortic valve disease 1 31.3 TNNI3 NPPB CRP ACE
43 toxic myocarditis 31.1 TNNI3 PIK3C2A NPPB
44 systemic scleroderma 31.1 SELP CRP ACE
45 dilated cardiomyopathy 31.1 TNNT2 TNNI3 NPPB MIR499A MB FABP3
46 aortic valve disease 2 31.1 NPPB CRP ACE
47 peripheral artery disease 31.1 SELP CRP CDKN2B-AS1 ACE
48 generalized atherosclerosis 31.0 SELP CRP ACE
49 stroke, ischemic 31.0 SELP PLAT F3 CRP CDKN2B-AS1 ACE
50 anuria 31.0 PIK3C2A MB ACE

Comorbidity relations with Acute Myocardial Infarction via Phenotypic Disease Network (PDN): (show all 19)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Aortic Valve Disease 1
Cardiac Arrest Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Kidney Disease Mitral Valve Disease
Peripheral Vascular Disease Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Acute Myocardial Infarction:



Diseases related to Acute Myocardial Infarction

Symptoms & Phenotypes for Acute Myocardial Infarction

UMLS symptoms related to Acute Myocardial Infarction:


angina pectoris, chest pain

MGI Mouse Phenotypes related to Acute Myocardial Infarction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.32 ACE CRP F3 FABP3 MB PIK3C2A

Drugs & Therapeutics for Acute Myocardial Infarction

Drugs for Acute Myocardial Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 535)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pravastatin Approved Phase 4 81093-37-0 54687
2
Insulin glargine Approved Phase 4 160337-95-1
3
Etanercept Approved, Investigational Phase 4 185243-69-0
4
Morphine Approved, Investigational Phase 4 57-27-2 5288826
5
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
6
Eplerenone Approved Phase 4 107724-20-9 150310 443872
7
Streptokinase Approved, Investigational Phase 4 9002-01-1
8 Nutmeg Approved Phase 4
9
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
10
Verapamil Approved Phase 4 52-53-9 2520
11
Liraglutide Approved Phase 4 204656-20-2 44147092
12
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
13
Ethanol Approved Phase 4 64-17-5 702
14
Edaravone Approved, Investigational Phase 4 89-25-8 70335
15
Histamine Approved, Investigational Phase 4 51-45-6 774
16
Esomeprazole Approved, Investigational Phase 4 119141-88-7, 161796-78-7, 161973-10-0 9568614 4594
17
Famotidine Approved Phase 4 76824-35-6 3325
18
Reteplase Approved, Investigational Phase 4 133652-38-7 65820
19
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
20 Apricot Approved Phase 4
21
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
22
Phylloquinone Approved, Investigational Phase 4 84-80-0
23
Aminophylline Approved Phase 4 317-34-0 9433
24
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
25
Abacavir Approved, Investigational Phase 4 136470-78-5 65140 441300
26
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
27
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
28
Caffeine Approved Phase 4 58-08-2 2519
29
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
30
Ezetimibe Approved Phase 4 163222-33-1 150311
31
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
32
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
33
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
34
Sodium citrate Approved, Investigational Phase 4 68-04-2
35
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
36
Desflurane Approved Phase 4 57041-67-5 42113
37
Triflusal Approved, Investigational Phase 4 322-79-2
38 fluindione Approved, Investigational Phase 4 957-56-2
39
Phenindione Approved, Investigational Phase 4 83-12-5 4760
40
Haloperidol Approved Phase 4 52-86-8 3559
41
Chromium Approved Phase 4 7440-47-3 27668
42
Cobalt Approved, Experimental Phase 4 7440-48-4 104729
43
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
44
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
45
Enalaprilat Approved Phase 4 76420-72-9 6917719
46
Rivaroxaban Approved Phase 4 366789-02-8
47
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
48
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
49
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
50
Hydralazine Approved Phase 4 86-54-4 3637

Interventional clinical trials:

(show top 50) (show all 1258)
# Name Status NCT ID Phase Drugs
1 Pravastatin for Acute Myocardial Infarction With Minimally to Mildly Increased Levels of Serum Cholesterol Study That Evaluates the Effects of Pravastatin for Acute Myocardial Infarction With LDL-Cholesterol Levels of 70-129 mg/dl Unknown status NCT00688922 Phase 4 Pravastatin
2 Erythropoietin Prevention Trial of Coronary Restenosis and Cardiac Remodeling After Acute Myocardial Infarction (EPOC-AMI) Unknown status NCT00423020 Phase 4 Erythropoietin
3 Randomized Study Of Sirolimus Eluting Stent Vs Conventional Stent In Acute Myocardial Infarction Acronym SESAMI Unknown status NCT00288210 Phase 4
4 Efficacy of Thrombosuction in Primary Percutaneous Coronary Intervention of Acute Myocardial Infarction Unknown status NCT01156662 Phase 4
5 Treating Acute MI Patients With Aggrastat on Their Way to Hospital Unknown status NCT00300833 Phase 4 Tirofiban
6 N-3 Fatty Acids for the Prevention of Atrial Fibrillation in Patients With Acute Heart Failure Unknown status NCT00692718 Phase 4 Epadel, Eicosapentaenoic acid
7 Study of Anti-inflammatory Treatment With Colchicine in the Acute Phase of ST-elevation Myocardial Infarction to Reduce Infarct Size Unknown status NCT01936285 Phase 4 Colchicine 2 mg loading dose; 0.5 mg bid for 5 days;Placebo
8 Role of Innate and Adaptive Immunity After Acute Myocardial Infarction BATTLE-AMI Study (B And T Types of Lymphocytes Evaluation in Acute Myocardial Infarction) Unknown status NCT02428374 Phase 4 Rosuvastatin plus clopidogrel;Rosuvastatin plus ticagrelor;Simvastatin plus clopidogrel;Simvastatin plus ticagrelor
9 Imaging of Inflammation in the Postischemic Myocardium: Effect of Anti-inflammatory Treatment With Colchicine Unknown status NCT02281305 Phase 4 Colchicine
10 Dissecting the Role of Distal Embolization of Athero-thrombotic Material in Primary PCI: the ThrombOticBurden and mIcrovAscularobStruction (TOBIAS) Study. Unknown status NCT01914055 Phase 4
11 Effect of Vitamin C Infusion on Coronary Reperfusion Indexes Unknown status NCT01090895 Phase 4 Vitamin C;Placebo
12 A Randomized Clinical Trial Comparing Primary PCI and Post-thrombolysis PCI as Reperfusion Strategies in Patients With ST Segment Elevation Acute Myocardial Infarction Unknown status NCT02268669 Phase 4
13 A Prospective, Multicenter, Randomized, Open-label Trial to Evaluate Efficacy and Safety of 5mg Maintenance Dose of Prasugrel in Patients With Acute Coronary Syndrome Who Underwent Percutaneous Coronary Intervention With BiomatrixTM Stent Unknown status NCT02446730 Phase 4 Prasugel;Clopidogrel
14 Evaluation of Neointimal Coverage of Everolimus-Eluting Stent and Bare-metal Stent After Implantation in STEMI Patients by Optical Coherence Tomography Unknown status NCT01875835 Phase 4
15 Thrombus Aspiration During Percutaneous Coronary Intervention in Acute Non-ST-elevation Myocardial Infarction Study (TAPAS II) Unknown status NCT01013038 Phase 4
16 Comparison of Ticagrelor and Clopidogrel on Reperfusion in Patients With AMI Undergoing PPCI Evaluated by SPECT Unknown status NCT02233790 Phase 4 Ticagrelor;Clopidogrel
17 Phase 4 Study of Primary Angioplasty Combined Distal Injection of Abciximab to Thrombus and Aspiration With Catheter Unknown status NCT01383785 Phase 4
18 The Safety and Efficacy of Etanercept in Treating Patient With Acute ST Segment Elevated Myocardial Infarction Unknown status NCT01372930 Phase 4 Etanercept;saline
19 Randomized Trial of Prasugrel Plus Bivalirudin vs. Clopidogrel Plus Heparin in Patients With Acute STEMI Unknown status NCT00976092 Phase 4 Prasugrel;Bivalirudin;Clopidogrel;Heparin
20 Effects of Sodium Tanshinone IIA Sulfonate on Left Ventricular Remodeling in Patients With ST-segment Elevation Myocardial Infarction Following Percutaneous Coronary Intervention Unknown status NCT02524964 Phase 4 sodium tanshinone IIA sulfonate
21 Effect of Early Administration of Intracoronary Nicorandil Via Thrombus Aspiration Catheter Device During Primary Percutaneous Coronary Intervention for the Patients of Acute ST Segment Elevation Myocardial Infarction Unknown status NCT02435797 Phase 4 Nicorandil;normal saline
22 Microvascular Reperfusion Utilizing Sonothrombolysis in Acute Myocardial Infarction (MRUSMI TRIAL) Unknown status NCT02170103 Phase 4 Microbubbles
23 Multicentre 2x2 Factorial Randomised Study Comparing Tirofiban Administered With the Single High-Dose Bolus Versus Abciximab and Sirolimus Eluting Stent Versus Bare Metal Stent in Acute Myocardial Infarction - MULTI-STRATEGY Trial Unknown status NCT00229515 Phase 4
24 Ticagrelor Versus Clopidogrel in Myocardial Salvage in Patients With ST-elevation Myocardial Infarction (STEMI) Undergoing Primary Percutaneous Coronary Intervention: A Magnetic Resonance Imaging Study (TIGER Study) Unknown status NCT02792712 Phase 4 Ticagrelor;Clopidogrel
25 Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease: a Randomized Clinical Trial Unknown status NCT01155128 Phase 4
26 Healthy Heart Study: Can Insulin Glargine Improve Myocardial Function in Patients With Type 2 Diabetes and Coronary Artery Disease? A Prospective, Randomized, Controlled Clinical Study With Blinded Analysis of Ultrasound Data Unknown status NCT01035528 Phase 4 insulin glargine;metformin
27 Effect of Rosuvastatin Therapy on HDL2 Level and Antiatherosclerotic Reverse Cholesterol Transport Process in Chinses CAD Patients With Hyperlipidemia Unknown status NCT02593487 Phase 4 Rosuvastatin 10mg/d group;Rosuvastatin 20mg/d group
28 A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE SUPPLEMENTATION WITH KIOLIC® IN PATIENTS WITH DIAGNOSIS OF METABOLIC SYNDROME TO IMPROVE ENDOTHELIAL FUNCTION AND INFLAMMATORY STATE. "KYMES" Unknown status NCT01168700 Phase 4 aged garlic extract;Placebo
29 Phase 4 Study of the Effect of Human Recombinant Erythropoietin at the Time of Reperfusion in Patients With Acute Myocardial Infarction Completed NCT00882466 Phase 4 human recombinant erythropoietin
30 Impact of Morphine Treatment on Platelet Inhibition in Acute Myocardial Infarction Completed NCT02627950 Phase 4 Morphinhydrochloricum;Metoclopramide;Ticagrelor;Isotonic sodium chloride
31 Comparison of Administration of Tirofiban in the Ambulance or in the Cathlab in Patients With Acute Myocardial Infarction Treated With Primary Angioplasty Completed NCT00538317 Phase 4 tirofiban;tirofiban
32 Comparison of Prasugrel and Ticagrelor in the Treatment of Acute Myocardial Infarction Completed NCT02808767 Phase 4 Prasugrel;Ticagrelor
33 Phase 4 Study of Application of Intracoronary Low Dose Streptokinase Complementary to Standard Percutaneous Coronary Intervention in Patients With ST Elevation Acute Myocardial Infarction: Effect of Adjunctive Intracoronary Streptokinase on Late Term Left Ventricular Infarct Size and Volumes in Patients With Acute Myocardial Infarction Completed NCT00627809 Phase 4 Streptokinase
34 Prospective Randomized Multicenter Study Comparing Immediate Multivessel Revascularization by PCI Versus Culprit Lesion PCI With Staged Non-culprit Lesion Revascularization in Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock Completed NCT01927549 Phase 4
35 Thrombus Aspiration Before Standard Primary Angioplasty Improves Myocardial Reperfusion in Acute Myocardial Infarction. Completed NCT00257153 Phase 4
36 Southwest German Interventional Study in Acute Myocardial Infarction III Completed NCT01124890 Phase 4
37 The Effects of Facilitated Percutaeous Coronary Intervention Compared to Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Acute Myocardial Infarction Completed NCT00611169 Phase 4 tirofiban
38 A Multi-center, Randomized, Controlled Study of Mechanical Left Ventricular Unloading With Counterpulsation to Reduce Infarct Size Pre-PCI for Acute Myocardial Infarction - CRISP AMI Completed NCT00833612 Phase 4
39 Reversal of No-reflow/Slow-flow During Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction--a Prospective Randomized Study Comparing Intracoronary Infusion of Diltiazem, Verapamil and Nitroglycerin Completed NCT00712894 Phase 4 Diltiazem;Verapamil;Nitroglycerin
40 Bivalirudin in Acute Myocardial Infarction vs Glycoprotein IIb/IIIa and Heparin Undergoing Angioplasty (BRIGHT):a Randomised Controlled Trial Completed NCT01696110 Phase 4 Bivalirudin;heparin;heparin plus tirofiban
41 AIR-MI: Assessment of Ischemia and Remodeling Following Acute Myocardial Infarction Completed NCT00162331 Phase 4 Technetium Tc99m Sestamibi
42 Safety and Efficacy of Levosimendan in Patients With Acute Myocardial Infarction Complicated by Symptomatic Left Ventricular Failure. Completed NCT00324766 Phase 4 levosimendan;placebo,
43 Randomized Clinical Study of Intraaortic Balloon Pump Use in Cardiogenic Shock Complicating Acute Myocardial Infarction Completed NCT00491036 Phase 4
44 Phase 4 Study of Atorvastatin 10mg vs. 40mg in Follow-up CFR in AMI Patients Completed NCT00536887 Phase 4 atorvastatin
45 Effects of Early Statin Treatment on Symptomatic Heart Failure and Ischemic Events After Acute Myocardial Infarction. The MUSASHI-AMI: A Multicenter Randomized Controlled Trial Completed NCT00128024 Phase 4 lipid-lowering treatment
46 A Comparison of Drug Eluting and Bare Metal Stents With or Without Abciximab in ST Segment Elevation Myocardial Infarction The Eindhoven Reperfusion Study Completed NCT00986050 Phase 4 Abciximab
47 The Contrast Media and Nephrotoxicity Following Coronary Revascularization by Primary Angioplasty for Acute Myocardial Infarction. The CONTRAST-AMI Study. Completed NCT00827788 Phase 4 Iodixanol;Iopromide
48 Prevention of Reperfusion Damage and Late Left Ventricular Remodelling With Atorvastatin Administered Before Reperfusion Therapy. The REPERATOR Study Completed NCT00286312 Phase 4 Atorvastatin
49 Randomized Comparison of Everolimus Eluting Stents and Sirolimus Eluting Stent in Patients With ST Elevation Myocardial Infarction (STEMI) (RaCES-MI Trial) Completed NCT01684982 Phase 4
50 Safety and Efficacy of Three Different Loading Doses of Clopidogrel, Administered at First Medical Contact in Patients With Acute Myocardial Infarction Undergoing Primary Angioplasty. The LOAD & GO Trial Completed NCT00882739 Phase 4 Clopidogrel 300 mg;Clopidogrel 600 mg;Clopidogrel 900 mg

Search NIH Clinical Center for Acute Myocardial Infarction

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Alteplase
Clopidogrel
Enoxaparin
Fondaparinux
Heparin
Lisinopril
Reteplase
Tenecteplase

Genetic Tests for Acute Myocardial Infarction

Anatomical Context for Acute Myocardial Infarction

MalaCards organs/tissues related to Acute Myocardial Infarction:

41
Heart, Bone, Testes, Endothelial, Bone Marrow, Kidney, Brain

Publications for Acute Myocardial Infarction

Articles related to Acute Myocardial Infarction:

(show top 50) (show all 30457)
# Title Authors PMID Year
1
Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease. 88
20921333 2010
2
Changes of matrix metalloproteinase-9 level is associated with left ventricular remodeling following acute myocardial infarction among patients treated with trandolapril, valsartan or both. 9 38
20378999 2010
3
Tissue plasminogen activator antigen predicts medium-term left ventricular end-systolic volume after acute myocardial infarction. 9 38
19662337 2010
4
Activation of peripheral blood mononuclear cells and extracellular matrix and inflammatory gene profile in acute myocardial infarction. 9 38
20388121 2010
5
Endothelin-1 release in acute myocardial infarction as a predictor of long-term prognosis and no-reflow assessed by contrast-enhanced magnetic resonance imaging. 9 38
20435200 2010
6
Left ventricular function and C-reactive protein levels in acute myocardial infarction. 9 38
20346306 2010
7
Point-of-care test of heart-type fatty acid-binding protein for the diagnosis of early acute myocardial infarction. 9 38
20140003 2010
8
[The significance of the changes in expressions of heat shock protein 70 and heme oxygenase-1 in the myocardium in patients died suddenly due to acute myocardial infarction]. 9 38
20170613 2010
9
Circulating p53 and cytochrome c levels in acute myocardial infarction patients. 9 38
19551350 2010
10
Comparison of usefulness of heart-type fatty acid binding protein versus cardiac troponin T for diagnosis of acute myocardial infarction. 9 38
20102882 2010
11
Noninvasive assessment of left ventricular filling pressure after acute myocardial infarction: a prospective study of the relative prognostic utility of clinical assessment, echocardiography, and B-type natriuretic peptide. 9 38
20102866 2010
12
Admission creatine kinase as a prognostic marker in acute myocardial infarction. 9 38
20201171 2009
13
Plasma thrombomodulin activity, tissue factor activity and high levels of circulating procoagulant phospholipid as prognostic factors for acute myocardial infarction. 9 38
19809306 2009
14
The profile of circulating metalloproteinases after PCI in patients with acute myocardial infarction or stable angina. 9 38
19410278 2009
15
TNF-alpha/IL-10 ratio and C-reactive protein as markers of the inflammatory response in CAD-prone North Indian patients with acute myocardial infarction. 9 38
19576194 2009
16
Increased expression of TF on monocytes, but decreased numbers of TF bearing microparticles in blood from patients with acute myocardial infarction. 9 38
19558505 2009
17
The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls. 9 38
19520708 2009
18
Carboxylated magnetic microbead-assisted fluoroimmunoassay for early biomarkers of acute myocardial infarction. 9 38
19398193 2009
19
Conjugation of biomolecules with magnetic protein microspheres for the assay of early biomarkers associated with acute myocardial infarction. 9 38
19555077 2009
20
[Correlation between serum MMP-2 and MMP-9 in patients with acute myocardial infarction before and after PCI]. 9 38
19664397 2009
21
The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction. 9 38
19637097 2009
22
Association of C-reactive protein and HIV infection with acute myocardial infarction. 9 38
19387353 2009
23
Plasma TF activity predicts cardiovascular mortality in patients with acute myocardial infarction. 9 38
19570241 2009
24
The impact of admission C-reactive protein levels on the development of no-reflow phenomenon after primary PCI in patients with acute myocardial infarction: the role of inflammation. 9 38
18579226 2009
25
[Study of association of platelet endothelial cell adhesion molecule-1 gene polymorphism with acute myocardial infarction]. 9 38
19570335 2009
26
Superparamagnetic microsphere-assisted fluoroimmunoassay for rapid assessment of acute myocardial infarction. 9 38
19394809 2009
27
Expressions of eNOS3 and Ve-cadherin in microvascular endothelium at 7-day of reperfused acute myocardial infarction. 9 38
19519369 2009
28
[An angiographic trial to evaluate the efficacy and safety of tenecteplase in Chinese patients with acute myocardial infarction]. 9 38
19927632 2009
29
C-terminal provasopressin (copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMAAL study. 9 38
19346228 2009
30
Human heart-type fatty acid-binding protein for on-site diagnosis of early acute myocardial infarction. 9 38
18571749 2009
31
Levels of serum deoxyribonuclease I activity on admission in patients with acute myocardial infarction can be useful in predicting left ventricular enlargement due to remodeling. 9 38
19304122 2009
32
[Coronary flow and hemorrhagic complications after alteplase and streptokinase administration in patients with acute myocardial infarction]. 9 38
19341228 2009
33
[The relationship between plasma BNP level and the left ventricular dysfunction parameters in patients with acute myocardial infarction and it's value in diagonosing heart failure.]. 9 38
19781144 2009
34
Impact of telmisartan on coronary stenting in patients with acute myocardial infarction compared with enalapril. 9 38
18190989 2009
35
Factors associated with C-reactive protein at the early stage of acute myocardial infarction in men. 9 38
19130414 2009
36
The relationship of plasminogen activator inhibitor-1 levels to the ST deviation pattern of acute myocardial infarction. 9 38
18580060 2009
37
Admission levels of C-reactive protein and plasminogen activator inhibitor-1 in patients with acute myocardial infarction with and without cardiogenic shock or heart failure on admission. 9 38
19246845 2009
38
Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry. 9 38
18997620 2009
39
Acute phase proteins and systolic dysfunction in subjects with acute myocardial infarction. 9 38
18038115 2008
40
[Plasma tissue factor and tissue factor pathway inhibitor levels in acute myocardial infarction patients with no-reflow during percutaneous coronary intervention]. 9 38
19102916 2008
41
[Comparative effect of streptokinase and alteplase on electrocardiogram and angiogram signs of myocardial reperfusion in ST segment elevation acute myocardial infarction]. 9 38
19069338 2008
42
Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation. 9 38
18810578 2008
43
Impact of plaque rupture and elevated C-reactive protein on clinical outcome in patients with acute myocardial infarction: an intravascular ultrasound study. 9 38
18762670 2008
44
Relationship of sustained brain natriuretic peptide release after reperfused acute myocardial infarction with gated SPECT infarct measurements and its connection with collagen turnover and left ventricular remodeling. 9 38
18761267 2008
45
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. 88
18723672 2008
46
Value of blood adipose tissue hormones concentration--adiponectin, resistin and leptin in the prediction of major adverse cardiac events (MACE) in 1-year follow-up after primary percutaneous coronary intervention in ST-segment elevation acute myocardial infarction. 9 38
18766137 2008
47
[Role of nuclear factor-KappaB in endothelial injury in acute myocardial infarction]. 9 38
18611340 2008
48
A close relationship between functional polymorphism in the promoter region of matrix metalloproteinase-9 and acute myocardial infarction. 9 38
17698228 2008
49
Effect of atrial natriuretic peptide on left ventricular remodelling in patients with acute myocardial infarction. 9 38
18490430 2008
50
Late ventricular remodeling in non-reperfused acute myocardial infarction in humans is predicted by angiotensin II type 1 receptor density on blood platelets. 9 38
17651844 2008

Variations for Acute Myocardial Infarction

Copy number variations for Acute Myocardial Infarction from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 210497 6 30400000 36600000 Amplification C4B Acute myocardial infarction

Expression for Acute Myocardial Infarction

LifeMap Discovery
Genes differentially expressed in tissues of Acute Myocardial Infarction patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 EGR3 early growth response 3 Blood + 5.52 0.000
2 LOC286058 uncharacterized LOC286058 Blood + 4.73 0.000
3 CXCL8 chemokine (C-X-C motif) ligand 8 Blood + 3.51 0.004
4 LEP leptin Heart + 3.45 0.011
5 ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein Blood + 3.18 0.007
Search GEO for disease gene expression data for Acute Myocardial Infarction.

Pathways for Acute Myocardial Infarction

Pathways related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.98 PLAT ACE

GO Terms for Acute Myocardial Infarction

Cellular components related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 SELP PLAT NPPB MIR29A FABP3 F3
2 troponin complex GO:0005861 9.16 TNNT2 TNNI3
3 cardiac myofibril GO:0097512 8.96 TNNT2 TNNI3
4 cardiac Troponin complex GO:1990584 8.62 TNNT2 TNNI3

Biological processes related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of vascular endothelial cell proliferation GO:1905564 9.37 MIR499A MIR29A
2 regulation of muscle contraction GO:0006937 9.32 TNNT2 TNNI3
3 heart contraction GO:0060047 9.26 TNNI3 ACE
4 regulation of blood vessel diameter GO:0097746 9.16 NPPB ACE
5 negative regulation of ATPase activity GO:0032780 8.96 TNNT2 TNNI3
6 transition between fast and slow fiber GO:0014883 8.62 MIR499A MIR208B

Molecular functions related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin C binding GO:0030172 8.62 TNNT2 TNNI3

Sources for Acute Myocardial Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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