MCID: ACT076
MIFTS: 46

Acute Myocarditis

Categories: Cardiovascular diseases, Immune diseases, Infectious diseases, Muscle diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Acute Myocarditis

MalaCards integrated aliases for Acute Myocarditis:

Name: Acute Myocarditis 11 53 14 71 31

Classifications:



External Ids:

Disease Ontology 11 DOID:3951
ICD9CM 34 422
NCIt 49 C35206
SNOMED-CT 68 155336004
ICD10 31 I40 I40.9
UMLS 71 C0155686

Summaries for Acute Myocarditis

MalaCards based summary: Acute Myocarditis is related to toxic myocarditis and third-degree atrioventricular block. An important gene associated with Acute Myocarditis is TNC (Tenascin C), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and NF-kappaB Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include heart, cardiac myocytes and myeloid, and related phenotypes are muscle and cardiovascular system

Related Diseases for Acute Myocarditis

Diseases in the Myocarditis family:

Autoimmune Myocarditis Acute Myocarditis
Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1076)
# Related Disease Score Top Affiliating Genes
1 toxic myocarditis 32.2 TNNI3 NPPB ACE
2 third-degree atrioventricular block 31.1 TNNI3 NPPB CRP ACE
3 atrioventricular block 30.9 TNNT2 TNNI3 NPPB CRP ACE
4 polyarteritis nodosa 30.5 TNF IL6 CRP
5 adult syndrome 30.4 TNF IL6 H2AC18 CRP
6 vascular disease 30.4 TNF TNC IL6 CRP ACE
7 cardiac tamponade 30.4 TNNI3 NPPB IL6 CRP ACE
8 coronary thrombosis 30.4 TNNI3 MIR499A CRP
9 churg-strauss syndrome 30.3 TNF IL1B IL10
10 euthyroid sick syndrome 30.2 NPPB IL6 IL1B
11 coronary stenosis 30.2 TNNI3 NPPB IL6 CRP ACE
12 coronary artery vasospasm 30.2 TNNT2 TNNT1 TNNI3 NPPB CRP ACE
13 toxoplasmosis 30.2 TNF IL6 IL1B IL10
14 hemopericardium 30.2 TNNI3 NPPB CRP
15 conjunctivitis 30.2 TNF IL6 IL10
16 severe acute respiratory syndrome 30.1 TNF IL6 IL1B IL10 CRP ACE2
17 cardiac tuberculosis 30.1 NPPB CRP ACE
18 myocarditis 30.1 TXN TNNT2 TNNT1 TNNI3 TNF NPPB
19 enterocolitis 30.1 TNF IL6 IL10 CRP
20 reactive arthritis 30.1 TNF CRP CCR6
21 rheumatic myocarditis 30.1 TNNT2 TNNI3 CRP
22 congestive heart failure 30.1 TNNT2 TNNI3 TNF NPPB IL6 IL1B
23 mononeuritis multiplex 30.1 TNF CRP CD4
24 cardiac arrest 30.1 TNNT2 TNNI3 NPPB MIR499A DSP CRP
25 macrophage activation syndrome 30.1 IL6 CRP ACE2
26 angina pectoris 30.1 TNNI3 TNF NPPB IL6 CRP ACE
27 first-degree atrioventricular block 30.0 TNNI3 NPPB CRP ACE
28 atrial fibrillation 30.0 TNNI3 NPPB IL6 CRP ACE
29 adult-onset still's disease 30.0 TNF IL6 IL1B CRP CCR6
30 arrhythmogenic right ventricular cardiomyopathy 30.0 TNNT2 TNNI3 MIR499A DSP
31 left ventricular noncompaction 30.0 TNNT2 TNNI3 DSP ACE
32 pheochromocytoma 30.0 TNF IL6 IL1B CRP ACE
33 lyme disease 30.0 TNF IL6 IL1B CRP
34 toxic shock syndrome 29.9 TNF IL6 IL1B IL10 CRP
35 acute myocardial infarction 29.9 TNNT2 TNNI3 TNF NPPB MIR499A IL6
36 pleural empyema 29.9 IL6 CRP CD4
37 disseminated intravascular coagulation 29.9 TNF IL6 IL10 CRP
38 ventricular septal defect 29.9 TNNT2 NPPB MIR499A H2AC18
39 glucosephosphate dehydrogenase deficiency 29.9 TNF IL6 CRP
40 vasculitis 29.9 TNF IL6 IL1B IL10 CRP
41 mitral valve insufficiency 29.9 TNNT2 TNNT1 TNNI3 NPPB CRP ACE
42 cardiac sarcoidosis 29.9 TNF NPPB DSP CRP ACE
43 diastolic heart failure 29.9 TNNT2 TNNI3 NPPB IL6 CRP ACE
44 granulomatosis with polyangiitis 29.9 TNF CRP CD8A CD4 CCR6
45 whipple disease 29.9 TNF CRP CD4
46 chlamydia 29.9 TNF IL6 IL1B IL10 CRP
47 amyloidosis 29.8 TNF NPPB IL6 IL1B CRP
48 gastroenteritis 29.8 TNF IL6 IL1B IL10 CRP
49 pulmonary embolism 29.8 TNNT2 TNNT1 TNNI3 NPPB CRP ACE2
50 tonsillitis 29.8 TNF IL6 IL1B IL10

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to Acute Myocarditis

Symptoms & Phenotypes for Acute Myocarditis

MGI Mouse Phenotypes related to Acute Myocarditis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.65 ACE2 DSP IL10 IL6 MIR499A NPPB
2 cardiovascular system MP:0005385 9.4 ACE ACE2 CCR6 CRP DSP IL10

Drugs & Therapeutics for Acute Myocarditis

Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 4894 5755
4
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5 1875
5
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 4159 6741
6
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7 4897
7 Antirheumatic Agents Phase 2, Phase 3
8 Adrenergic beta-Antagonists Phase 2, Phase 3
9 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
10 Antineoplastic Agents, Hormonal Phase 3
11 Neuroprotective Agents Phase 3
12 Hormones Phase 3
13 Hormone Antagonists Phase 3
14 Antiemetics Phase 3
15 glucocorticoids Phase 3
16 Pharmaceutical Solutions Phase 3
17 Anti-Inflammatory Agents Phase 3
18
Methylprednisolone Acetate Phase 3 584547
19 Gastrointestinal Agents Phase 3
20 Protective Agents Phase 3
21
Cannabidiol Approved, Investigational Phase 2 13956-29-1 521372 644019
22 Anticonvulsants Phase 2
23
Dalfampridine Approved 504-24-5 1727
24
Iodine Approved, Investigational 7553-56-2 807
25
Somatostatin Approved, Investigational 38916-34-6, 51110-01-1 53481605 16129706
26
Cadexomer iodine Experimental 94820-09-4
27 Radiopharmaceuticals
28
Edotreotide 23724894
29 Fluorodeoxyglucose F18

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Anakinra Versus Placebo Double Blind Randomized Controlled Trial for the Treatment of Acute MyocarditIS Completed NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
2 Single Blind Randomized Controlled Trial to Assess the Safety and Efficacy of High Dose Pulse Intravenous Corticosteroid Therapy to Treat Patients With Complicated/Fulminant Acute Myocarditis Recruiting NCT05150704 Phase 3 Methylprednisolone;saline solution
3 Impact of CardiolRx on Myocardial Recovery in Acute Myocarditis. A Double-blind, Placebo-controlled Trial Recruiting NCT05180240 Phase 2 CardiolRx
4 Hospital Registry of Acute Myocarditis: Evolution of the Proportion of Positive SARS-COV-2 Cases During the Covid-19 Pandemic, Case Characteristics and Prognoses Unknown status NCT04375748
5 Recurrent Acute Myocarditis : Characteristics, Etiology, Prognosis and Genetic Basis. Unknown status NCT04589156
6 Cardiac Magnetic Resonance Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance Unknown status NCT03525639
7 Prospective Assessment of the Clinical Utility of Cardiovascular Magnetic Resonance in Patients With Suspected Acute Myocarditis - A Pilot Study for Establishing an International Registry Unknown status NCT01307735
8 DZHK TranslatiOnal Registry for CardiomyopatHies Deutsches Zentrum für Herz- Und Kreislauf-Forschung (DZHK) Unknown status NCT02187263
9 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
10 Value of CMR Including T1 Mapping in Patients With Acute Myocarditis Completed NCT01962584
11 Role of Electrocardiograms in Risk Stratification and Analysis of the Characteristics of ST Elevation in Acute Myocarditis: A Two-center Study Completed NCT04498494
12 Evaluation of Long-term Incidence of Ventricular Arrhythmias in Patients With Acute Myocarditis Recruiting NCT04264455
13 Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children Recruiting NCT04420468
14 Acute Myocarditis Registry With Prognostic, Histologic, Immunologic, Biological, Imaging and Clinical Assessment Recruiting NCT04844151
15 Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis Recruiting NCT02905721
16 Somatostatin Receptor Imaging in Inflammatory Heart Disease Recruiting NCT04206163

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

Anatomical Context for Acute Myocarditis

Organs/tissues related to Acute Myocarditis:

MalaCards : Heart, Cardiac Myocytes, Myeloid, T Cells, B Cells, Kidney, Lung

Publications for Acute Myocarditis

Articles related to Acute Myocarditis:

(show top 50) (show all 2107)
# Title Authors PMID Year
1
Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy. 53 62
17322629 2007
2
Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis. 53 62
15685595 2005
3
Redox regulation by thioredoxin in cardiovascular diseases. 53 62
14588153 2003
4
Exercise After Acute Myocarditis: When and How to Return to Sports. 62
36368807 2023
5
STEMI in an adolescent boy due to anomalous left main coronary artery arising from the right sinus of Valsalva: Case report and brief review of the literature. 62
36324853 2023
6
Sports, Myocarditis and COVID-19: Diagnostics, Prevention and Return-to-play Strategies. 62
35345017 2022
7
What acute cardiac care physicians need to know from the latest 2022 ESC Guidelines for Ventricular Tachycardia and Sudden Cardiac Death. 62
36449983 2022
8
Unexpected Cardiotoxicity in Patients With HER2-Mutant NSCLC Treated With Trastuzumab Deruxtecan: A Case Report. 62
36471682 2022
9
A Successful Case of Cardiac Arrest due to Acute Myocarditis with COVID-19: 120 Minutes on Manual Cardiopulmonary Resuscitation then Veno-Arterial Extracorporeal Membrane Oxygenation. 62
36193699 2022
10
Safety and usefulness of left ventricular endomyocardial biopsy in new- onset acute heart failure requiring mechanical support by an Impella® device. 62
35944774 2022
11
An autopsy case report of fulminant myocarditis: Following mRNA COVID-19 vaccination. 62
35812802 2022
12
[Diagnostic and prognostic utility of cardiac magnetic resonance imaging in myocarditis]. 62
36257848 2022
13
Radiomics analysis of short tau inversion recovery images in cardiac magnetic resonance for the prediction of late gadolinium enhancement in patients with acute myocarditis. 62
36116711 2022
14
Atrial Impairment as a Marker in Discriminating Between Takotsubo and Acute Myocarditis Using Cardiac Magnetic Resonance. 62
36306267 2022
15
Acute myocarditis after COVID-19 vaccination. 62
36379527 2022
16
Contrast-enhanced cine MR sequences in the assessment of myocardial hyperemia in acute myocarditis: can they help? A feasibility study. 62
36436026 2022
17
A Novel Circulating MicroRNA for the Detection of Acute Myocarditis. 62
36378600 2022
18
Follow-Up Cardiovascular Magnetic Resonance Findings in Patients With COVID-19 Vaccination-Associated Acute Myocarditis. 62
36357142 2022
19
A 17-year-old boy with chest pain and transient ventricular wall thickening. 62
35322779 2022
20
Machine learning approach in diagnosing Takotsubo cardiomyopathy: The role of the combined evaluation of atrial and ventricular strain, and parametric mapping. 62
36410545 2022
21
Development of efficient, sensitive, and specific detection method for Encephalomyocarditis virus based on CRISPR/Cas13a. 62
35905814 2022
22
Natural History of Myocardial Injury After COVID-19 Vaccine-Associated Myocarditis. 62
35944800 2022
23
Low prevalence of cardiac abnormalities in competitive athletes at return-to-play after COVID-19. 62
36372623 2022
24
Clinical characteristics and mortality risk prediction model in children with acute myocarditis. 62
36378481 2022
25
COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation. 62
36441403 2022
26
Acute Myocarditis: A New Manifestation of Monkeypox Infection? 62
36249878 2022
27
Acute Myocardial Infarction in a 13-Year-Old Boy after Bone Marrow Transplantation. 62
36369122 2022
28
Genetic Architecture of Acute Myocarditis and the Overlap With Inherited Cardiomyopathy. 62
36154167 2022
29
Brugada pattern in adolescent with acute myocarditis due to SARS-CoV-2. 62
36176505 2022
30
Acute Myocarditis After Severe Acute Respiratory Syndrome Coronavirus 2 Infection. 62
36267333 2022
31
Clinical and electrocardiographic characteristics in patients with fulminant myocarditis. 62
36237853 2022
32
Case report of eosinophilic granulomatosis with polyangitis presenting as acute myocarditis. 62
36245446 2022
33
Right ventricular peak systolic free wall longitudinal strain as a practical tool to detect right ventricular dysfunction in acute myocarditis. 62
36126335 2022
34
Hereditary thrombotic thrombocytopenic purpura and COVID-19: Impacts of vaccination and infection in this rare disease. 62
36284639 2022
35
COVID-19 and the heart. 62
36246800 2022
36
Diagnosis of Concomitant Myocarditis in a 13-Year-Old Patient with Crohn's Disease. 62
36360391 2022
37
Cardiac MRI Findings in COVID-19 Vaccine-Related Myocarditis: A Pooled Analysis of 468 Patients. 62
35612967 2022
38
First report of myocarditis in two patients with COVID-19 Omicron variant: case report. 62
36285226 2022
39
Exercise Stress Test Late after Arrhythmic versus Nonarrhythmic Presentation of Myocarditis. 62
36294841 2022
40
Acute Myocarditis After COVID-19 Vaccination. 62
36381020 2022
41
Acute myocarditis following a third dose of COVID-19 mRNA vaccination in adults. 62
35870635 2022
42
Comprehensive Cardiovascular Magnetic Resonance-Derived Myocardial Strain Analysis Provides Independent Prognostic Value in Acute Myocarditis. 62
36129042 2022
43
Multimodality imaging in acute myocarditis. 62
36218216 2022
44
Left Ventricular Mass with Delayed Enhancement as a Predictor of Major Events in Patients with Myocarditis with Preserved Ejection Fraction. 62
36294403 2022
45
Acute Myocarditis: No Longer a PET Peeve? 62
36202458 2022
46
Predicting factors and outcomes of acute myocarditis in children - a 5-year experience in a teaching hospital from the Eastern province of Saudi Arabia. 62
36420287 2022
47
Dynamic Change of Left Ventricular Mechanics in Patients with Acute Myocarditis with Preserved Left Ventricular Systolic Function: A 2-Year Follow-up Study. 62
36200716 2022
48
Acute Myocarditis Associated With Desmosomal Gene Variants. 62
36175056 2022
49
Global longitudinal strain by CMR improves prognostic stratification in acute myocarditis presenting with normal LVEF. 62
35598175 2022
50
Acute Myocarditis After Discontinuation of Immune Checkpoint Inhibitor Therapy. 62
36310041 2022

Variations for Acute Myocarditis

Expression for Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for Acute Myocarditis

Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 TNF IL6 IL1B IL10 CD4
2 12.5 TXN TNF IL1B IL10 CD8A
3 12.12 TNF IL6 IL1B IL10
4
Show member pathways
12.09 CD4 CD8A IL10 TNF
5 12.05 TNF IL6 IL1B IL10
6 11.9 TNF IL6 IL10 CD8A CD4
7 11.89 TNF IL6 IL1B IL10
8
Show member pathways
11.77 TNF IL6 IL1B IL10 CD4
9 11.71 IL6 IL10 CD4
10
Show member pathways
11.7 TNNT2 TNNT1 TNNI3
11 11.7 TNF TNC IL6 IL1B
12 11.67 IL6 IL1B CD4
13 11.66 TNF IL6 IL10 CRP
14
Show member pathways
11.62 TNF IL6 IL1B
15 11.61 TNF IL6 IL10
16 11.6 TNF IL6 IL1B DSP
17
Show member pathways
11.58 TNF IL6 IL10
18 11.57 TNF IL6 IL1B IL10
19
Show member pathways
11.54 IL6 CRP CD8A CD4 ACE2
20 11.54 TNF IL1B IL10 CD8A CD4 CCR6
21 11.52 TNF IL10 ACE2
22 11.45 TNF IL6 IL1B
23 11.43 TNF IL6 IL1B IL10
24 11.27 TNF IL6 IL1B
25 11.25 IL10 IL1B IL6 TNF
26 11.2 TNF IL6 IL1B
27 11.17 TNF IL6 IL10
28 11.1 TNF IL6 IL1B ACE2
29 11.05 IL10 IL1B IL6
30 10.99 TNF IL6 CRP
31 10.97 TNF IL6 IL1B IL10 CD8A CD4
32 10.82 TNF IL6 IL1B IL10 CD4
33 10.66 IL6 ACE2
34
Show member pathways
10.33 TNF IL6

GO Terms for Acute Myocarditis

Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cardiac Troponin complex GO:1990584 9.26 TNNT2 TNNI3
2 troponin complex GO:0005861 9.1 TNNT2 TNNT1 TNNI3

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 10.19 TNF IL6 IL1B CRP
2 positive regulation of DNA-binding transcription factor activity GO:0051091 10.19 TNF IL6 IL1B IL10
3 immune response GO:0006955 10.11 CCR6 CD4 CD8A IL10 IL1B IL6
4 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.05 IL10 IL6 TNF
5 blood vessel diameter maintenance GO:0097746 10.03 NPPB ACE2 ACE
6 liver regeneration GO:0097421 10.02 TNF IL6 IL10
7 negative regulation of neurogenesis GO:0050768 9.99 IL1B IL6 TNF
8 skeletal muscle contraction GO:0003009 9.97 TNNT1 TNNI3 TNF
9 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.91 ACE2 ACE
10 negative regulation of cytokine production involved in immune response GO:0002719 9.91 TNF IL10
11 positive regulation of glial cell proliferation GO:0060252 9.91 TNF IL6 IL1B
12 positive regulation of fever generation GO:0031622 9.9 TNF IL1B
13 sequestering of triglyceride GO:0030730 9.87 TNF IL1B
14 positive regulation of peptidyl-cysteine S-nitrosylation GO:2000170 9.84 TXN ACE
15 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.83 TNF IL1B
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.8 TNF IL1B IL10
17 negative regulation of gap junction assembly GO:1903597 9.78 IL1B ACE
18 chronic inflammatory response to antigenic stimulus GO:0002439 9.76 TNF IL10
19 positive regulation of neuroinflammatory response GO:0150078 9.63 TNF IL6 IL1B
20 regulation of muscle contraction GO:0006937 9.43 TNNT2 TNNT1 TNNI3
21 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
22 regulation of system process GO:0044057 9.4 TNNT2 TNNT1
23 vascular endothelial growth factor production GO:0010573 9.1 TNF IL6 IL1B

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin T binding GO:0031014 9.46 TNNT1 TNNI3
2 troponin C binding GO:0030172 9.26 TNNT2 TNNI3
3 peptidyl-dipeptidase activity GO:0008241 8.92 ACE2 ACE

Sources for Acute Myocarditis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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