MCID: ACT076
MIFTS: 46

Acute Myocarditis

Categories: Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Acute Myocarditis

MalaCards integrated aliases for Acute Myocarditis:

Name: Acute Myocarditis 12 54 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:3951
ICD9CM 34 422
NCIt 49 C35206
SNOMED-CT 67 46701001
ICD10 32 I40 I40.9
UMLS 71 C0155686

Summaries for Acute Myocarditis

MalaCards based summary : Acute Myocarditis is related to toxic myocarditis and cardiogenic shock. An important gene associated with Acute Myocarditis is TLR3 (Toll Like Receptor 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Hematinics and Ferrosoferric Oxide have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and cardiac myocytes, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Related Diseases for Acute Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 592)
# Related Disease Score Top Affiliating Genes
1 toxic myocarditis 32.8 TNNI3 NPPB ACE
2 cardiogenic shock 31.2 NPPB CRP
3 atrioventricular block 30.9 TNNI3 NPPB ACE
4 atrial standstill 1 30.2 TNNT2 TNNI3 NPPB ACE
5 coronary artery vasospasm 30.1 TNNI3 CRP ACE
6 right bundle branch block 30.1 TNNI3 NPPB ACE
7 diastolic heart failure 30.1 TNNI3 NPPB ACE
8 cardiac tamponade 30.1 TNNI3 NPPB CRP ACE
9 pericardial effusion 30.0 TNNI3 NPPB CRP CD4 ACE
10 coronary stenosis 29.9 TNNI3 NPPB CRP ACE
11 cardiac tuberculosis 29.8 NPPB CRP ACE
12 first-degree atrioventricular block 29.8 NPPB CRP ACE
13 myocarditis 29.7 TXN TNNI3 TNF TLR3 NPPB IL10
14 rheumatic myocarditis 29.6 TNNT2 TNNI3 CRP
15 chlamydia 29.5 TNF IL10 CRP
16 angina pectoris 29.5 TNNI3 NPPB CRP ACE
17 epidemic typhus 29.5 IL10 CRP CD4
18 cardiac sarcoidosis 29.4 ZIC3 TNF ACE
19 heart septal defect 29.4 ZIC3 TNNT2 H2AC18
20 lupus erythematosus 29.4 TNF IL10 FASLG CD86 CD40
21 toxoplasmosis 29.4 TNF STAT1 IL10 CD40
22 hepatitis a 29.4 TNF TLR3 IL10
23 histoplasmosis 29.3 TNF STAT1 CD4
24 mumps 29.3 TNF TLR3 STAT1 IL10
25 conjunctivitis 29.3 TNF TLR3 IL10
26 granulomatosis with polyangiitis 29.3 TNF CRP CD86 CD4
27 rubella 29.3 TNF TLR3 IL10
28 leptospirosis 29.2 TNF IL10 CRP
29 poliomyelitis 29.2 TNF IL10 CD4
30 tonsillitis 29.2 TNF TLR3 IL10
31 severe combined immunodeficiency 29.2 IL10 H2AC18 CD70 CD40 CD4
32 pulmonary embolism 29.2 TNNT2 TNNI3 NPPB CRP ACE
33 mononeuritis multiplex 29.2 TNF CRP CD4
34 encephalitis 29.1 TNF TLR3 STAT1 IL10
35 endophthalmitis 29.1 TNF CRP CD4
36 dengue hemorrhagic fever 29.1 TNF TLR3 STAT1 IL10
37 toxic shock syndrome 29.1 TNF IL10 CRP CD86 CD40
38 pneumonia 29.1 TNF TLR3 IL10 CRP ACE
39 scrub typhus 29.1 TNF IL10 CRP
40 aseptic meningitis 29.0 TNF IL10 CRP
41 appendicitis 29.0 TNF IL10 CRP
42 atrial fibrillation 29.0 TNNT2 TNNI3 NPPB CRP ACE
43 congestive heart failure 29.0 TNNT2 TNNI3 TNF NPPB CRP ACE
44 mouth disease 29.0 TLR3 STAT1 NPPB IL10 H2AC18 CRP
45 osteomyelitis 29.0 TNF STAT1 IL10
46 atherosclerosis susceptibility 28.9 TNF CRP CD40 ACE
47 chagas disease 28.9 TNF NPPB IL10 CD4 ACE
48 sarcoidosis 1 28.9 TNF STAT1 CRP CD86 CD4 ACE
49 restrictive cardiomyopathy 28.9 ZIC3 TNNT2 TNNI3 NPPB ACE
50 reactive arthritis 28.9 TNF IL10 CRP

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to Acute Myocarditis

Symptoms & Phenotypes for Acute Myocarditis

GenomeRNAi Phenotypes related to Acute Myocarditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ACE
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 ACE CD70 FAS FASLG IL10 STAT1
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.7 CD40 ZIC3
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CD70 FAS IL10 STAT1 TNF ZIC3
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 ACE CD70 FAS IL10 STAT1 TNF

MGI Mouse Phenotypes related to Acute Myocarditis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ACE CD4 CD40 CD86 CRP FAS
2 cardiovascular system MP:0005385 10.22 ACE CRP FAS FASLG IL10 STAT1
3 hematopoietic system MP:0005397 10.21 ACE CD4 CD40 CD70 CD86 FAS
4 immune system MP:0005387 10.18 ACE CD4 CD40 CD70 CD86 CRP
5 endocrine/exocrine gland MP:0005379 10.16 ACE CD4 CD40 CD86 FAS FASLG
6 nervous system MP:0003631 9.93 CD4 CD40 CD86 FAS FASLG IL10
7 muscle MP:0005369 9.92 CD86 FAS IL10 STAT1 TLR3 TNF
8 neoplasm MP:0002006 9.8 ACE FAS FASLG IL10 STAT1 TLR3
9 normal MP:0002873 9.61 CD4 CD40 FAS FASLG IL10 STAT1
10 respiratory system MP:0005388 9.23 FAS FASLG IL10 STAT1 TLR3 TNF

Drugs & Therapeutics for Acute Myocarditis

Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hematinics Phase 2, Phase 3
2 Ferrosoferric Oxide Phase 2, Phase 3
3 Pharmaceutical Solutions Phase 2, Phase 3
4 Parenteral Nutrition Solutions Phase 2, Phase 3
5 Adrenergic beta-Antagonists Phase 2, Phase 3
6 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
7
Iodine Approved, Investigational 7553-56-2 807
8
Somatostatin Approved, Investigational 38916-34-6, 51110-01-1 53481605
9
4-Aminopyridine Approved 504-24-5 1727
10
Hydroxychloroquine Approved Early Phase 1 118-42-3 3652
11 cadexomer iodine
12 Edotreotide
13 Radiopharmaceuticals
14 Immunoglobulins
15 Antibodies
16 Antibodies, Monoclonal
17 Antirheumatic Agents Early Phase 1
18 Fluorodeoxyglucose F18
19 Anti-Infective Agents Early Phase 1
20 Antiprotozoal Agents Early Phase 1
21 Antiparasitic Agents Early Phase 1
22 Antimalarials Early Phase 1

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
2 Anakinra Versus Placebo Double Blind Randomized Controlled Trial for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
3 DZHK TranslatiOnal Registry for CardiomyopatHies Deutsches Zentrum für Herz- Und Kreislauf-Forschung (DZHK) Unknown status NCT02187263
4 Prospective Assessment of the Clinical Utility of Cardiovascular Magnetic Resonance in Patients With Suspected Acute Myocarditis - A Pilot Study for Establishing an International Registry Unknown status NCT01307735
5 The Role of Functional Active Anti-Angiotensin-Receptor 1 (ATR1)- and Anti-Endothelin-Receptor A (ETRA)-Antibodies and Autoreactive T Cells in Cardiomyopathy Unknown status NCT02319590
6 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
7 Value of CMR Including T1 Mapping in Patients With Acute Myocarditis Completed NCT01962584
8 Clinical, Morphological and Functional Aspects in Acute and Chronic Myocarditis. Completed NCT04217876
9 A Pilot Study to Explore the Role of Physical Activity as a Quality of Life Intervention in Advanced Cancer Patients Completed NCT00438620
10 Hospital Registry of Acute Myocarditis: Evolution of the Proportion of Positive SARS-COV-2 Cases During the Covid-19 Pandemic, Case Characteristics and Prognoses Recruiting NCT04375748
11 Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis Recruiting NCT02905721
12 Somatostatin Receptor Imaging in Inflammatory Heart Disease Recruiting NCT04206163
13 Cardiac Magnetic Resonance Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance Recruiting NCT03525639
14 Evaluation of Long-term Incidence of Ventricular Arrhythmias in Patients With Acute Myocarditis Recruiting NCT04264455
15 A Prospective Randomised Trial of Early LV Venting Using Impella CP for Recovery in Patients With Cardiogenic Shock Managed With VA ECMO Recruiting NCT03431467
16 Cardiovascular Manifestations of Hospitalized Patients With Coronavirus Disease 2019 Recruiting NCT04335630
17 French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRI Active, not recruiting NCT02717143
18 Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis Active, not recruiting NCT04312490
19 Quantification of Ventricular Arrhythmia After Myocarditis in Sportsman Not yet recruiting NCT03842592
20 Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children Not yet recruiting NCT04420468
21 Multi-modality Imaging & Immunophenotyping of COVID-19 Related Myocardial Injury Not yet recruiting NCT04412369
22 Hydroxychloroquine for the Treatment of Patients With Mild to Moderate COVID-19 to Prevent Progression to Severe Infection or Death Not yet recruiting NCT04323631 Early Phase 1 Hydroxychloroquine

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

Anatomical Context for Acute Myocarditis

MalaCards organs/tissues related to Acute Myocarditis:

40
Heart, T Cells, Cardiac Myocytes, Liver, Lung, Kidney, Myeloid

Publications for Acute Myocarditis

Articles related to Acute Myocarditis:

(show top 50) (show all 1640)
# Title Authors PMID Year
1
Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy. 54 61
17322629 2007
2
Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis. 54 61
15685595 2005
3
Redox regulation by thioredoxin in cardiovascular diseases. 54 61
14588153 2003
4
Strain analysis reveals subtle systolic dysfunction in confirmed and suspected myocarditis with normal LVEF. A cardiac magnetic resonance study. 61
31828505 2020
5
Lithium chloride confers protection against viral myocarditis via suppression of coxsackievirus B3 virus replication. 61
32205210 2020
6
Diagnostic Accuracy of Mapping Techniques and Postprocessing Methods for Acute Myocarditis. 61
32286878 2020
7
Role of thrombin generation assays in the diagnosis of acute myocarditis and non-ST myocardial infarction. 61
31754904 2020
8
Imaging Cardiovascular Emergencies: Real World Clinical Cases. 61
32503756 2020
9
Development of a Pulsatile Flow-Generating Circulatory Assist Device (K-Beat) For Use with Veno-Arterial Extracorporeal Membrane Oxygenation in a Pig Model Study. 61
32545599 2020
10
Sex-Based Differences in Characteristics and In-Hospital Outcomes among Patients With Diagnosed Acute Myocarditis. 61
32278464 2020
11
Elevated aldolase 1A, retrogene 1 expression induces cardiac apoptosis in rat experimental autoimmune myocarditis model. 61
31999472 2020
12
First documentation of persistent SARS-CoV-2 infection presenting with late acute severe myocarditis. 61
32522523 2020
13
COVID-19-Associated Myocarditis in an Adolescent. 61
32502128 2020
14
Acute myocarditis associated with COVID-19 infection. 61
32507570 2020
15
COVID-19 Pandemic: Cardiovascular Complications and Future Implications. 61
32578167 2020
16
Acute myocarditis following varicella zoster infection in an immunocompetent adolescent: An uncommon complication. 61
32470266 2020
17
Cardiac MRI of Children with Multisystem Inflammatory Syndrome (MIS-C) Associated with COVID-19: Case Series. 61
32515676 2020
18
Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. 61
32488505 2020
19
QRS fragmentation as a possible electrocardiographic diagnostic marker in patients with acute myocarditis: preliminary histopathological validation. 61
32562382 2020
20
Update on acute myocarditis. 61
32497572 2020
21
Progressive myocardial lipomatous metaplasia following acute myocarditis. 61
31876908 2020
22
A case of Behcet's disease myocarditis documented by cardiac magnetic resonance imaging. 61
32416317 2020
23
Editorial for "Children With Acute Myocarditis Often Have Persistent Subclinical Changes as Revealed by Cardiac Magnetic Resonance". 61
32406139 2020
24
Early T1 Myocardial MRI Mapping: Value in Detecting Myocardial Hyperemia in Acute Myocarditis. 61
32154772 2020
25
Impact of ventricular arrhythmias on outcomes in children with myocarditis. 61
32447560 2020
26
miR-16 exhibits protective function in LPS-treated cardiomyocytes by targeting DOCK2 to repress cell apoptosis and exert anti-inflammatory effect. 61
32369253 2020
27
A Prospective Pilot Study to Identify a Myocarditis Cohort who may Safely Resume Sports Activities 3 Months after Diagnosis. 61
32367345 2020
28
QRS fragmentation in children with suspected myocarditis: a possible additional diagnostic sign. 61
32468976 2020
29
Could phenothiazine-benznidazole combined chemotherapy be effective in controlling heart parasitism and acute infectious myocarditis? 61
32416214 2020
30
Hemodynamic collapse after influenza vaccination: a vaccine-induced fulminant myocarditis? 61
32413549 2020
31
Fulminant myocarditis following recurrent generalized erythrokeratoderma in a child with a heterozygous GJA1 variant. 61
32449269 2020
32
Acute myocarditis by enzalutamide. 61
32444324 2020
33
Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection. 61
32267502 2020
34
Acute Myocarditis Triggers Coronary Artery Spasm: A Rare Association. 61
32376061 2020
35
Use of Early T1 Mapping for MRI in Acute Myocarditis. 61
32159451 2020
36
Acute Myocarditis After Black Widow Spider Bite: A Case Report. 61
32462634 2020
37
Familial screening in case of acute myocarditis reveals inherited arrhythmogenic left ventricular cardiomyopathies. 61
32356610 2020
38
Diagnostic and prognostic role of electrocardiogram in acute myocarditis: A comprehensive review. 61
31778001 2020
39
The prognostic value of late gadolinium enhancement in myocarditis and clinically suspected myocarditis: systematic review and meta-analysis. 61
32040731 2020
40
Potential mechanisms of cardiac injury and common pathways of inflammation in patients with COVID-19. 61
32467423 2020
41
[Acute myocarditis caused by anti-PD-1 monoclonal antibody in the treatment of refractory Hodgkin lymphoma: a case report]. 61
32482034 2020
42
Possible new options and benefits to detect myocarditis, right ventricular remodeling and coronary anomalies by echocardiography in systematic preparticipation screening of athletes. 61
32462448 2020
43
Predictors of 30-day Survival in Cardiogenic Shock Patients on Impella 5.0 and 5.5 Circulatory Support. 61
32465707 2020
44
Epidemiology Characteristics and Outcome of Patients With Clinically Diagnosed Acute Myocarditis. 61
31712098 2020
45
Diagnostic values of edema-sensitive T2-weighted imaging, TSE T1-weighted early contrast-enhanced imaging, late gadolinium enhancement, and the Lake Louise criteria in assessing acute myocarditis: A single-center cardiac magnetic resonance study. 61
32281957 2020
46
Myocarditis in the Athlete: Arrhythmogenic Substrates, Clinical Manifestations, Management, and Eligibility Decisions. 61
32270467 2020
47
Heart Dysfunction Following Long-Term Murine Cytomegalovirus Infection: Fibrosis, Hypertrophy, and Tachycardia. 61
32286167 2020
48
First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. 61
32277408 2020
49
A case of suspected eosinophilic myocarditis recognized by a fully noninvasive approach and safely treated with corticosteroids despite an underling Hepatitis C virus-hepatitis. 61
32316745 2020
50
Clinical observation of noncoronary cardiac abnormalities in Chinese children with Kawasaki disease. 61
32061097 2020

Variations for Acute Myocarditis

Expression for Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for Acute Myocarditis

Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 TXN TNF TLR3 STAT1 IL10 FASLG
2
Show member pathways
13.79 TNF TNC STAT1 IL10 FASLG FAS
3
Show member pathways
13.31 TNF TLR3 STAT1 IL10 FASLG FAS
4
Show member pathways
13.3 TNF STAT1 IL10 FASLG CD86 CD70
5
Show member pathways
13.27 TNF IL10 FASLG FAS CD70 CD40
6
Show member pathways
12.95 TNF TNC TLR3 STAT1 FASLG FAS
7
Show member pathways
12.84 TNF TLR3 STAT1 FASLG FAS CD86
8 12.75 TNF TLR3 STAT1 FASLG FAS
9
Show member pathways
12.74 TNF TLR3 STAT1 FASLG FAS CD40
10
Show member pathways
12.6 TNF IL10 CD86 CD40 CD4
11
Show member pathways
12.55 TNF STAT1 FASLG FAS CD70 CD40
12
Show member pathways
12.54 TNF STAT1 IL10 FAS CD4
13
Show member pathways
12.53 TNF STAT1 IL10 CD86 CD4
14
Show member pathways
12.5 TNF STAT1 IL10 FASLG FAS CD86
15
Show member pathways
12.5 TNF TLR3 STAT1 IL10 FASLG FAS
16
Show member pathways
12.49 TNF TLR3 FASLG FAS CD70 CD40
17 12.38 TXN TNF TLR3 STAT1 IL10 FASLG
18
Show member pathways
12.25 TXN TNF STAT1 FASLG FAS
19
Show member pathways
12.23 TNF STAT1 IL10 CD40
20
Show member pathways
12.22 TNNT2 TNNI3 TNF ACE
21 12.21 TXN TNF FASLG FAS
22
Show member pathways
12.14 TNF STAT1 FASLG FAS
23
Show member pathways
11.96 TNF TLR3 STAT1 H2AC18 FASLG FAS
24 11.94 TNF IL10 CD86 CD4
25 11.93 TNF STAT1 IL10 FASLG
26
Show member pathways
11.8 TLR3 STAT1 CD86 CD4
27 11.75 TNF IL10 CD4
28 11.71 TNF IL10 CD4
29
Show member pathways
11.68 TNF FASLG FAS CD70 CD40
30 11.52 TNF FASLG FAS
31 11.5 TNF IL10 CD40
32 11.49 TNF IL10 CD86
33 11.45 IL10 CD86 CD4
34 11.42 TNF FASLG FAS
35 11.33 TNF IL10 FASLG FAS
36
Show member pathways
11.29 TNF IL10 FASLG FAS
37 11.19 TNF IL10 CD4
38
Show member pathways
11.13 TNF TLR3 STAT1 IL10 CD86 CD4

GO Terms for Acute Myocarditis

Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TXN TNF TNC NPPB IL10 FASLG
2 extracellular space GO:0005615 9.85 TNF TNC TLR3 NPPB IL10 FASLG
3 membrane raft GO:0045121 9.73 TNF FASLG FAS CD4
4 cell surface GO:0009986 9.5 TNF TLR3 FASLG FAS CD86 CD40
5 troponin complex GO:0005861 9.4 TNNT2 TNNI3
6 cardiac myofibril GO:0097512 9.37 TNNT2 TNNI3
7 cardiac Troponin complex GO:1990584 9.26 TNNT2 TNNI3
8 external side of plasma membrane GO:0009897 9.17 TNF FASLG FAS CD86 CD40 CD4

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.97 ZIC3 TNF STAT1 IL10 CD86 CD4
2 positive regulation of protein phosphorylation GO:0001934 9.86 TNF FAS CD40 CD4
3 cellular response to lipopolysaccharide GO:0071222 9.85 TNF IL10 CD86 CD40
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.8 TNF TLR3 FASLG CD40 CD4
5 cytokine-mediated signaling pathway GO:0019221 9.8 TNF STAT1 IL10 FASLG CD86 CD4
6 immune response GO:0006955 9.8 TNF IL10 FASLG FAS CD86 CD70
7 cellular response to mechanical stimulus GO:0071260 9.77 TLR3 FAS CD40
8 positive regulation of T cell proliferation GO:0042102 9.74 CD86 CD70 CD4
9 apoptotic signaling pathway GO:0097190 9.67 TNF TLR3 FASLG FAS
10 B cell proliferation GO:0042100 9.65 IL10 CD70 CD40
11 tumor necrosis factor-mediated signaling pathway GO:0033209 9.63 TNF STAT1 FASLG FAS CD70 CD40
12 negative regulation of lipid storage GO:0010888 9.58 TNF CRP
13 endothelial cell apoptotic process GO:0072577 9.58 TNF IL10
14 negative regulation of cytokine production involved in immune response GO:0002719 9.54 TNF IL10
15 regulation of immunoglobulin secretion GO:0051023 9.52 TNF CD40
16 negative regulation of cytokine secretion involved in immune response GO:0002740 9.51 TNF IL10
17 positive regulation of peptidyl-cysteine S-nitrosylation GO:2000170 9.46 TXN ACE
18 receptor biosynthetic process GO:0032800 9.43 TNF IL10
19 extrinsic apoptotic signaling pathway GO:0097191 9.35 TNF TLR3 FASLG FAS CD70
20 necroptotic signaling pathway GO:0097527 8.92 TNF TLR3 FASLG FAS

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.21 ZIC3 TXN TNNT2 TNNI3 TNF TNC
2 cytokine activity GO:0005125 9.62 TNF IL10 FASLG CD70
3 signaling receptor activity GO:0038023 9.35 TLR3 FAS CD86 CD40 CD4
4 troponin C binding GO:0030172 9.16 TNNT2 TNNI3
5 tumor necrosis factor receptor binding GO:0005164 8.92 TNF STAT1 FASLG CD70

Sources for Acute Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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