Acute Myocarditis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Acute Myocarditis is related to toxic myocarditis and third-degree atrioventricular block. An important gene associated with Acute Myocarditis is TNC (Tenascin C), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and NF-kappaB Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include heart, cardiac myocytes and myeloid, and related phenotypes are muscle and cardiovascular system

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Related Diseases for Acute Myocarditis

Diseases in the Myocarditis family:

Autoimmune Myocarditis	Acute Myocarditis
Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1076)

#	Related Disease	Score	Top Affiliating Genes
1	toxic myocarditis	32.2	TNNI3 NPPB ACE
2	third-degree atrioventricular block	31.1	TNNI3 NPPB CRP ACE
3	atrioventricular block	30.9	TNNT2 TNNI3 NPPB CRP ACE
4	polyarteritis nodosa	30.5	TNF IL6 CRP
5	adult syndrome	30.4	TNF IL6 H2AC18 CRP
6	vascular disease	30.4	TNF TNC IL6 CRP ACE
7	cardiac tamponade	30.4	TNNI3 NPPB IL6 CRP ACE
8	coronary thrombosis	30.4	TNNI3 MIR499A CRP
9	churg-strauss syndrome	30.3	TNF IL1B IL10
10	euthyroid sick syndrome	30.2	NPPB IL6 IL1B
11	coronary stenosis	30.2	TNNI3 NPPB IL6 CRP ACE
12	coronary artery vasospasm	30.2	TNNT2 TNNT1 TNNI3 NPPB CRP ACE
13	toxoplasmosis	30.2	TNF IL6 IL1B IL10
14	hemopericardium	30.2	TNNI3 NPPB CRP
15	conjunctivitis	30.2	TNF IL6 IL10
16	severe acute respiratory syndrome	30.1	TNF IL6 IL1B IL10 CRP ACE2
17	cardiac tuberculosis	30.1	NPPB CRP ACE
18	myocarditis	30.1	TXN TNNT2 TNNT1 TNNI3 TNF NPPB
19	enterocolitis	30.1	TNF IL6 IL10 CRP
20	reactive arthritis	30.1	TNF CRP CCR6
21	rheumatic myocarditis	30.1	TNNT2 TNNI3 CRP
22	congestive heart failure	30.1	TNNT2 TNNI3 TNF NPPB IL6 IL1B
23	mononeuritis multiplex	30.1	TNF CRP CD4
24	cardiac arrest	30.1	TNNT2 TNNI3 NPPB MIR499A DSP CRP
25	macrophage activation syndrome	30.1	IL6 CRP ACE2
26	angina pectoris	30.1	TNNI3 TNF NPPB IL6 CRP ACE
27	first-degree atrioventricular block	30.0	TNNI3 NPPB CRP ACE
28	atrial fibrillation	30.0	TNNI3 NPPB IL6 CRP ACE
29	adult-onset still's disease	30.0	TNF IL6 IL1B CRP CCR6
30	arrhythmogenic right ventricular cardiomyopathy	30.0	TNNT2 TNNI3 MIR499A DSP
31	left ventricular noncompaction	30.0	TNNT2 TNNI3 DSP ACE
32	pheochromocytoma	30.0	TNF IL6 IL1B CRP ACE
33	lyme disease	30.0	TNF IL6 IL1B CRP
34	toxic shock syndrome	29.9	TNF IL6 IL1B IL10 CRP
35	acute myocardial infarction	29.9	TNNT2 TNNI3 TNF NPPB MIR499A IL6
36	pleural empyema	29.9	IL6 CRP CD4
37	disseminated intravascular coagulation	29.9	TNF IL6 IL10 CRP
38	ventricular septal defect	29.9	TNNT2 NPPB MIR499A H2AC18
39	glucosephosphate dehydrogenase deficiency	29.9	TNF IL6 CRP
40	vasculitis	29.9	TNF IL6 IL1B IL10 CRP
41	mitral valve insufficiency	29.9	TNNT2 TNNT1 TNNI3 NPPB CRP ACE
42	cardiac sarcoidosis	29.9	TNF NPPB DSP CRP ACE
43	diastolic heart failure	29.9	TNNT2 TNNI3 NPPB IL6 CRP ACE
44	granulomatosis with polyangiitis	29.9	TNF CRP CD8A CD4 CCR6
45	whipple disease	29.9	TNF CRP CD4
46	chlamydia	29.9	TNF IL6 IL1B IL10 CRP
47	amyloidosis	29.8	TNF NPPB IL6 IL1B CRP
48	gastroenteritis	29.8	TNF IL6 IL1B IL10 CRP
49	pulmonary embolism	29.8	TNNT2 TNNT1 TNNI3 NPPB CRP ACE2
50	tonsillitis	29.8	TNF IL6 IL1B IL10

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):

Heart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:

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Symptoms & Phenotypes for Acute Myocarditis

MGI Mouse Phenotypes related to Acute Myocarditis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	9.65	ACE2 DSP IL10 IL6 MIR499A NPPB
2	cardiovascular system	MP:0005385	9.4	ACE ACE2 CCR6 CRP DSP IL10

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Drugs & Therapeutics for Acute Myocarditis

Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Prednisolone phosphate

Approved, Vet_approved

Phase 3

302-25-0

2

Prednisolone acetate

Approved, Vet_approved

Phase 3

52-21-1

3

Prednisolone

Approved, Vet_approved

Phase 3

50-24-8

4894 5755

4

Methylprednisolone hemisuccinate

Approved

Phase 3

2921-57-5

1875

5

Methylprednisolone

Approved, Vet_approved

Phase 3

83-43-2

4159 6741

6

Prednisolone hemisuccinate

Experimental

Phase 3

2920-86-7

4897

7

Antirheumatic Agents

Phase 2, Phase 3

8

Adrenergic beta-Antagonists

Phase 2, Phase 3

9

Interleukin 1 Receptor Antagonist Protein

Phase 2, Phase 3

10

Antineoplastic Agents, Hormonal

Phase 3

11

Neuroprotective Agents

Phase 3

12

Hormones

Phase 3

13

Hormone Antagonists

Phase 3

14

Antiemetics

Phase 3

15

glucocorticoids

Phase 3

16

Pharmaceutical Solutions

Phase 3

17

Anti-Inflammatory Agents

Phase 3

18

Methylprednisolone Acetate

Phase 3

584547

19

Gastrointestinal Agents

Phase 3

20

Protective Agents

Phase 3

21

Cannabidiol

Approved, Investigational

Phase 2

13956-29-1

521372 644019

22

Anticonvulsants

Phase 2

23

Dalfampridine

Approved

504-24-5

1727

24

Iodine

Approved, Investigational

7553-56-2

807

25

Somatostatin

Approved, Investigational

38916-34-6, 51110-01-1

53481605 16129706

26

Cadexomer iodine

Experimental

94820-09-4

27

Radiopharmaceuticals

28

Edotreotide

23724894

29

Fluorodeoxyglucose F18

Interventional clinical trials:

(show all 16)

#	Name	Status	NCT ID	Phase	Drugs
1	Anakinra Versus Placebo Double Blind Randomized Controlled Trial for the Treatment of Acute MyocarditIS	Completed	NCT03018834	Phase 2, Phase 3	ANAKINRA 100 mg/daily subcutaneously;Placebo
2	Single Blind Randomized Controlled Trial to Assess the Safety and Efficacy of High Dose Pulse Intravenous Corticosteroid Therapy to Treat Patients With Complicated/Fulminant Acute Myocarditis	Recruiting	NCT05150704	Phase 3	Methylprednisolone;saline solution
3	Impact of CardiolRx on Myocardial Recovery in Acute Myocarditis. A Double-blind, Placebo-controlled Trial	Recruiting	NCT05180240	Phase 2	CardiolRx
4	Hospital Registry of Acute Myocarditis: Evolution of the Proportion of Positive SARS-COV-2 Cases During the Covid-19 Pandemic, Case Characteristics and Prognoses	Unknown status	NCT04375748
5	Recurrent Acute Myocarditis : Characteristics, Etiology, Prognosis and Genetic Basis.	Unknown status	NCT04589156
6	Cardiac Magnetic Resonance Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance	Unknown status	NCT03525639
7	Prospective Assessment of the Clinical Utility of Cardiovascular Magnetic Resonance in Patients With Suspected Acute Myocarditis - A Pilot Study for Establishing an International Registry	Unknown status	NCT01307735
8	DZHK TranslatiOnal Registry for CardiomyopatHies Deutsches Zentrum für Herz- Und Kreislauf-Forschung (DZHK)	Unknown status	NCT02187263
9	Cardiac Magnetic Resonance in Acute Myocarditis	Completed	NCT02299856
10	Value of CMR Including T1 Mapping in Patients With Acute Myocarditis	Completed	NCT01962584
11	Role of Electrocardiograms in Risk Stratification and Analysis of the Characteristics of ST Elevation in Acute Myocarditis: A Two-center Study	Completed	NCT04498494
12	Evaluation of Long-term Incidence of Ventricular Arrhythmias in Patients With Acute Myocarditis	Recruiting	NCT04264455
13	Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children	Recruiting	NCT04420468
14	Acute Myocarditis Registry With Prognostic, Histologic, Immunologic, Biological, Imaging and Clinical Assessment	Recruiting	NCT04844151
15	Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis	Recruiting	NCT02905721
16	Somatostatin Receptor Imaging in Inflammatory Heart Disease	Recruiting	NCT04206163

Search NIH Clinical Center for Acute Myocarditis

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Genetic Tests for Acute Myocarditis

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Anatomical Context for Acute Myocarditis

Organs/tissues related to Acute Myocarditis:

MalaCards : Heart, Cardiac Myocytes, Myeloid, T Cells, B Cells, Kidney, Lung

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Publications for Acute Myocarditis

Articles related to Acute Myocarditis:

(show top 50) (show all 2107)

#	Title	Authors	PMID	Year
1	Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy. ⁵³ ⁶²	Terasaki F...Kitabatake A	17322629	2007
2	Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis. ⁵³ ⁶²	Morimoto S...Hiroe M	15685595	2005
3	Redox regulation by thioredoxin in cardiovascular diseases. ⁵³ ⁶²	Shioji K...Yodoi J	14588153	2003
4	Exercise After Acute Myocarditis: When and How to Return to Sports. ⁶²	Bryde RE...Martinez MW	36368807	2023
5	STEMI in an adolescent boy due to anomalous left main coronary artery arising from the right sinus of Valsalva: Case report and brief review of the literature. ⁶²	Li C...Li X	36324853	2023
6	Sports, Myocarditis and COVID-19: Diagnostics, Prevention and Return-to-play Strategies. ⁶²	Schmidt T...Reiss N	35345017	2022
7	What acute cardiac care physicians need to know from the latest 2022 ESC Guidelines for Ventricular Tachycardia and Sudden Cardiac Death. ⁶²	Goette A...Gorenek B	36449983	2022
8	Unexpected Cardiotoxicity in Patients With HER2-Mutant NSCLC Treated With Trastuzumab Deruxtecan: A Case Report. ⁶²	Riudavets M...Planchard D	36471682	2022
9	A Successful Case of Cardiac Arrest due to Acute Myocarditis with COVID-19: 120 Minutes on Manual Cardiopulmonary Resuscitation then Veno-Arterial Extracorporeal Membrane Oxygenation. ⁶²	Hoang BH...Nakahara S	36193699	2022
10	Safety and usefulness of left ventricular endomyocardial biopsy in new- onset acute heart failure requiring mechanical support by an Impella® device. ⁶²	Tschope C...Alogna A	35944774	2022
11	An autopsy case report of fulminant myocarditis: Following mRNA COVID-19 vaccination. ⁶²	Hoshino N...Izawa H	35812802	2022
12	[Diagnostic and prognostic utility of cardiac magnetic resonance imaging in myocarditis]. ⁶²	Huang F...Ben Amer H	36257848	2022
13	Radiomics analysis of short tau inversion recovery images in cardiac magnetic resonance for the prediction of late gadolinium enhancement in patients with acute myocarditis. ⁶²	Cavallo AU...Garaci F	36116711	2022
14	Atrial Impairment as a Marker in Discriminating Between Takotsubo and Acute Myocarditis Using Cardiac Magnetic Resonance. ⁶²	Cau R...Saba L	36306267	2022
15	Acute myocarditis after COVID-19 vaccination. ⁶²	Saadi SM...Alsulimani LK	36379527	2022
16	Contrast-enhanced cine MR sequences in the assessment of myocardial hyperemia in acute myocarditis: can they help? A feasibility study. ⁶²	Laissy JP...Bendriss A	36436026	2022
17	A Novel Circulating MicroRNA for the Detection of Acute Myocarditis. ⁶²		36378600	2022
18	Follow-Up Cardiovascular Magnetic Resonance Findings in Patients With COVID-19 Vaccination-Associated Acute Myocarditis. ⁶²	Patel YR...Atalay MK	36357142	2022
19	A 17-year-old boy with chest pain and transient ventricular wall thickening. ⁶²	Dakik HA	35322779	2022
20	Machine learning approach in diagnosing Takotsubo cardiomyopathy: The role of the combined evaluation of atrial and ventricular strain, and parametric mapping. ⁶²	Cau R...Saba L	36410545	2022
21	Development of efficient, sensitive, and specific detection method for Encephalomyocarditis virus based on CRISPR/Cas13a. ⁶²	Wei N...Cao S	35905814	2022
22	Natural History of Myocardial Injury After COVID-19 Vaccine-Associated Myocarditis. ⁶²	Mustafa Alhussein M...White JA	35944800	2022
23	Low prevalence of cardiac abnormalities in competitive athletes at return-to-play after COVID-19. ⁶²	Maestrini V...Di Giacinto B	36372623	2022
24	Clinical characteristics and mortality risk prediction model in children with acute myocarditis. ⁶²	Zhuang SX...Huang GY	36378481	2022
25	COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation. ⁶²	Furqan M...Klein A	36441403	2022
26	Acute Myocarditis: A New Manifestation of Monkeypox Infection? ⁶²	Pinho AI...Macedo F	36249878	2022
27	Acute Myocardial Infarction in a 13-Year-Old Boy after Bone Marrow Transplantation. ⁶²	Shi Y...Zhang W	36369122	2022
28	Genetic Architecture of Acute Myocarditis and the Overlap With Inherited Cardiomyopathy. ⁶²	Lota AS...Prasad SK	36154167	2022
29	Brugada pattern in adolescent with acute myocarditis due to SARS-CoV-2. ⁶²	Bergamo D...Nelson C	36176505	2022
30	Acute Myocarditis After Severe Acute Respiratory Syndrome Coronavirus 2 Infection. ⁶²	LaJoie J...Lentz B	36267333	2022
31	Clinical and electrocardiographic characteristics in patients with fulminant myocarditis. ⁶²	Itoh T...Morino Y	36237853	2022
32	Case report of eosinophilic granulomatosis with polyangitis presenting as acute myocarditis. ⁶²	Bjorkenstam M...Bollano E	36245446	2022
33	Right ventricular peak systolic free wall longitudinal strain as a practical tool to detect right ventricular dysfunction in acute myocarditis. ⁶²	Maharlou M...Farrashi M	36126335	2022
34	Hereditary thrombotic thrombocytopenic purpura and COVID-19: Impacts of vaccination and infection in this rare disease. ⁶²	Tarasco E...Kremer Hovinga JA	36284639	2022
35	COVID-19 and the heart. ⁶²	Xanthopoulos A...Skoularigis J	36246800	2022
36	Diagnosis of Concomitant Myocarditis in a 13-Year-Old Patient with Crohn's Disease. ⁶²	Kim JH...Kim YI	36360391	2022
37	Cardiac MRI Findings in COVID-19 Vaccine-Related Myocarditis: A Pooled Analysis of 468 Patients. ⁶²	Samimisedeh P...Rastad H	35612967	2022
38	First report of myocarditis in two patients with COVID-19 Omicron variant: case report. ⁶²	Fishman B...Matetzky S	36285226	2022
39	Exercise Stress Test Late after Arrhythmic versus Nonarrhythmic Presentation of Myocarditis. ⁶²	Peretto G...Mazzone P	36294841	2022
40	Acute Myocarditis After COVID-19 Vaccination. ⁶²	Cheon DY...Ryu KH	36381020	2022
41	Acute myocarditis following a third dose of COVID-19 mRNA vaccination in adults. ⁶²	Simone A...Lee MS	35870635	2022
42	Comprehensive Cardiovascular Magnetic Resonance-Derived Myocardial Strain Analysis Provides Independent Prognostic Value in Acute Myocarditis. ⁶²	Vos JL...Nijveldt R	36129042	2022
43	Multimodality imaging in acute myocarditis. ⁶²	Muscogiuri G...Sironi S	36218216	2022
44	Left Ventricular Mass with Delayed Enhancement as a Predictor of Major Events in Patients with Myocarditis with Preserved Ejection Fraction. ⁶²	Ghionzoli N...Focardi M	36294403	2022
45	Acute Myocarditis: No Longer a PET Peeve? ⁶²	Amara RS...Dickfeld T	36202458	2022
46	Predicting factors and outcomes of acute myocarditis in children - a 5-year experience in a teaching hospital from the Eastern province of Saudi Arabia. ⁶²	Albuali W	36420287	2022
47	Dynamic Change of Left Ventricular Mechanics in Patients with Acute Myocarditis with Preserved Left Ventricular Systolic Function: A 2-Year Follow-up Study. ⁶²	Poyraz E...Dinc Asarcikli L	36200716	2022
48	Acute Myocarditis Associated With Desmosomal Gene Variants. ⁶²	Ammirati E...Cooper LT	36175056	2022
49	Global longitudinal strain by CMR improves prognostic stratification in acute myocarditis presenting with normal LVEF. ⁶²	Porcari A...Sinagra G	35598175	2022
50	Acute Myocarditis After Discontinuation of Immune Checkpoint Inhibitor Therapy. ⁶²	Tamura Y...Imanaka-Yoshida K	36310041	2022

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Genes for Acute Myocarditis

Genes related to Acute Myocarditis (0 elite genes):

(show all 23)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TNC	Tenascin C	Protein Coding	10.44	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15685595 17322629
2	TNNI3	Troponin I3, Cardiac Type	Protein Coding	7.49	DISEASES inferred ¹⁴
3	MIR499A	MicroRNA 499a	RNA Gene	7.44	DISEASES inferred ¹⁴ ¹⁴
4	H2AC18	H2A Clustered Histone 18	Protein Coding	7.22	DISEASES inferred ¹⁴ ¹⁴
5	CRP	C-Reactive Protein	Protein Coding	6.98	DISEASES inferred ¹⁴
6	NPPB	Natriuretic Peptide B	Protein Coding	6.96	DISEASES inferred ¹⁴
7	ACE	Angiotensin I Converting Enzyme	Protein Coding	6.84	DISEASES inferred ¹⁴
8	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	6.79	DISEASES inferred ¹⁴
9	MIR3912	MicroRNA 3912	RNA Gene	6.7	DISEASES inferred ¹⁴ ¹⁴
10	TNNT1	Troponin T1, Slow Skeletal Type	Protein Coding	6.52	DISEASES inferred ¹⁴
11	IL6	Interleukin 6	Protein Coding	6.49	DISEASES inferred ¹⁴
12	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	6.43	DISEASES inferred ¹⁴ ¹⁴
13	TNNT2	Troponin T2, Cardiac Type	Protein Coding	6.32	DISEASES inferred ¹⁴
14	TXN	Thioredoxin	Protein Coding	6.31	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	14588153
15	IL1B	Interleukin 1 Beta	Protein Coding	6.1	DISEASES inferred ¹⁴
16	TNF	Tumor Necrosis Factor	Protein Coding	6.08	DISEASES inferred ¹⁴
17	IL10	Interleukin 10	Protein Coding	6.07	DISEASES inferred ¹⁴
18	CD4	CD4 Molecule	Protein Coding	6.02	DISEASES inferred ¹⁴
19	CD8A	CD8a Molecule	Protein Coding	5.87	DISEASES inferred ¹⁴
20	DSP	Desmoplakin	Protein Coding	5.86	DISEASES inferred ¹⁴
21	REN	Renin	Protein Coding	5.85	DISEASES inferred ¹⁴
22	CD68	CD68 Molecule	Protein Coding	5.83	DISEASES inferred ¹⁴
23	PKP2	Plakophilin 2	Protein Coding	5.74	DISEASES inferred ¹⁴

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Variations for Acute Myocarditis

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Expression for Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

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Pathways for Acute Myocarditis

Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 34)

#	Super pathways	Score	Top Affiliating Genes
1	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.53	TNF IL6 IL1B IL10 CD4
2	NF-kappaB Signaling ³	12.5	TXN TNF IL1B IL10 CD8A
3	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.12	TNF IL6 IL1B IL10
4	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.09	CD4 CD8A IL10 TNF
5	Neuroinflammation and glutamatergic signaling ⁷⁴	12.05	TNF IL6 IL1B IL10
6	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.9	TNF IL6 IL10 CD8A CD4
7	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.89	TNF IL6 IL1B IL10
8	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.77	TNF IL6 IL1B IL10 CD4
9	Acute viral myocarditis ⁷⁴	11.71	IL6 IL10 CD4
10	Striated muscle contraction pathway ⁷⁴ Show member pathways Striated Muscle Contraction ⁶⁶	11.7	TNNT2 TNNT1 TNNI3
11	Burn wound healing ⁷⁴	11.7	TNF TNC IL6 IL1B
12	Th17 cell differentiation pathway ⁷⁴	11.67	IL6 IL1B CD4
13	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.66	TNF IL6 IL10 CRP
14	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.62	TNF IL6 IL1B
15	miRNAs involvement in the immune response in sepsis ⁷⁴	11.61	TNF IL6 IL10
16	Lung fibrosis ⁷⁴	11.6	TNF IL6 IL1B DSP
17	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.58	TNF IL6 IL10
18	IL 10 signaling pathway ⁶⁷	11.57	TNF IL6 IL1B IL10
19	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.54	IL6 CRP CD8A CD4 ACE2
20	Innate Lymphoid Cells Differentiation ⁶⁵	11.54	TNF IL1B IL10 CD8A CD4 CCR6
21	SARS-CoV-2 innate immunity evasion and cell-specific immune response ⁷⁴	11.52	TNF IL10 ACE2
22	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.45	TNF IL6 IL1B
23	Interleukin-10 signaling ⁶⁶	11.43	TNF IL6 IL1B IL10
24	Development and heterogeneity of the ILC family ⁷⁴	11.27	TNF IL6 IL1B
25	IL-10 Pathway ⁶⁴	11.25	IL10 IL1B IL6 TNF
26	Prostaglandin signaling ⁷⁴	11.2	TNF IL6 IL1B
27	Immune infiltration in pancreatic cancer ⁷⁴	11.17	TNF IL6 IL10
28	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.1	TNF IL6 IL1B ACE2
29	LDL- influence on CD14 and TLR4 ⁷⁴	11.05	IL10 IL1B IL6
30	Overview of nanoparticle effects ⁷⁴	10.99	TNF IL6 CRP
31	Dendritic Cells Developmental Lineage Pathway ⁶⁵	10.97	TNF IL6 IL1B IL10 CD8A CD4
32	Cytokines and inflammatory response ⁷⁴	10.82	TNF IL6 IL1B IL10 CD4
33	COVID-19 adverse outcome pathway ⁷⁴	10.66	IL6 ACE2
34	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.33	TNF IL6

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GO Terms for Acute Myocarditis

Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cardiac Troponin complex	GO:1990584	9.26	TNNT2 TNNI3
2	troponin complex	GO:0005861	9.1	TNNT2 TNNT1 TNNI3

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 23)

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response to Gram-positive bacterium	GO:0050830	10.19	TNF IL6 IL1B CRP
2	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.19	TNF IL6 IL1B IL10
3	immune response	GO:0006955	10.11	CCR6 CD4 CD8A IL10 IL1B IL6
4	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.05	IL10 IL6 TNF
5	blood vessel diameter maintenance	GO:0097746	10.03	NPPB ACE2 ACE
6	liver regeneration	GO:0097421	10.02	TNF IL6 IL10
7	negative regulation of neurogenesis	GO:0050768	9.99	IL1B IL6 TNF
8	skeletal muscle contraction	GO:0003009	9.97	TNNT1 TNNI3 TNF
9	regulation of systemic arterial blood pressure by renin-angiotensin	GO:0003081	9.91	ACE2 ACE
10	negative regulation of cytokine production involved in immune response	GO:0002719	9.91	TNF IL10
11	positive regulation of glial cell proliferation	GO:0060252	9.91	TNF IL6 IL1B
12	positive regulation of fever generation	GO:0031622	9.9	TNF IL1B
13	sequestering of triglyceride	GO:0030730	9.87	TNF IL1B
14	positive regulation of peptidyl-cysteine S-nitrosylation	GO:2000170	9.84	TXN ACE
15	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.83	TNF IL1B
16	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.8	TNF IL1B IL10
17	negative regulation of gap junction assembly	GO:1903597	9.78	IL1B ACE
18	chronic inflammatory response to antigenic stimulus	GO:0002439	9.76	TNF IL10
19	positive regulation of neuroinflammatory response	GO:0150078	9.63	TNF IL6 IL1B
20	regulation of muscle contraction	GO:0006937	9.43	TNNT2 TNNT1 TNNI3
21	negative regulation of lipid storage	GO:0010888	9.43	TNF IL6 CRP
22	regulation of system process	GO:0044057	9.4	TNNT2 TNNT1
23	vascular endothelial growth factor production	GO:0010573	9.1	TNF IL6 IL1B

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	troponin T binding	GO:0031014	9.46	TNNT1 TNNI3
2	troponin C binding	GO:0030172	9.26	TNNT2 TNNI3
3	peptidyl-dipeptidase activity	GO:0008241	8.92	ACE2 ACE

Sources

Sources for Acute Myocarditis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ACT076 MIFTS: 46	Acute Myocarditis Categories: Cardiovascular diseases, Immune diseases, Infectious diseases, Muscle diseases, Rare diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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