MCID: ACT076
MIFTS: 47

Acute Myocarditis

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Acute Myocarditis

MalaCards integrated aliases for Acute Myocarditis:

Name: Acute Myocarditis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3951
ICD10 33 I40 I40.9
ICD9CM 35 422 422.90
NCIt 50 C35206
UMLS 73 C0155686

Summaries for Acute Myocarditis

MalaCards based summary : Acute Myocarditis is related to myocarditis and giant cell myocarditis. An important gene associated with Acute Myocarditis is TLR3 (Toll Like Receptor 3), and among its related pathways/superpathways are ERK Signaling and Cytokine Signaling in Immune system. The drugs Ferrosoferric Oxide and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and cardiac myocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Acute Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 myocarditis 30.6 CD40 CD86 TNNI3
2 giant cell myocarditis 10.6
3 penicilliosis 10.4 CD40 CD86
4 exanthema subitum 10.3 CD40 CD86
5 myocardial infarction 10.3
6 keloids 10.2 FAS TNC
7 acute myocardial infarction 10.2
8 dilated cardiomyopathy 10.1
9 atrioventricular block 10.1
10 fiedler's myocarditis 10.1
11 septic myocarditis 10.1
12 japanese encephalitis 10.1 STAT1 TLR3
13 type ii mixed cryoglobulinemia 10.0 FAS FASLG
14 influenza 10.0
15 lymphocytic gastritis 10.0 FAS FASLG
16 aneurysm 10.0
17 lymphomatoid papulosis 9.9 FAS FASLG
18 systemic lupus erythematosus 9.9
19 lupus erythematosus 9.9
20 cardiogenic shock 9.9
21 cartilage-hair hypoplasia 9.9 FAS FASLG
22 atrial standstill 1 9.9
23 pericarditis 9.9
24 pheochromocytoma 9.8
25 cardiomyopathy, familial hypertrophic, 1 9.8
26 aging 9.8
27 pneumonia 9.8
28 ventricular fibrillation, paroxysmal familial, 1 9.7
29 wegener granulomatosis 9.7
30 malaria 9.7
31 kawasaki disease 9.7
32 cardiac tamponade 9.7
33 coronary artery vasospasm 9.7
34 hypertrophic cardiomyopathy 9.7
35 parametritis 9.7
36 ischemia 9.7
37 cerebritis 9.7
38 myopathy 9.7
39 neuronitis 9.7
40 diastolic heart failure 9.7
41 severe cutaneous adverse reaction 9.7 FAS FASLG TLR3
42 epstein-barr virus-associated gastric carcinoma 9.7 FAS FASLG
43 hashimoto thyroiditis 9.6 CD40 FAS FASLG
44 common variable immunodeficiency 9.6 CD40 CD70 CD86 FAS
45 graves' disease 9.6 CD40 FAS FASLG
46 scleroderma, familial progressive 9.6
47 enterocolitis 9.6
48 paine syndrome 9.6
49 naxos disease 9.6
50 dermatitis, atopic 9.6

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):


Heart Disease Ischemic Heart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to Acute Myocarditis

Symptoms & Phenotypes for Acute Myocarditis

GenomeRNAi Phenotypes related to Acute Myocarditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 CD70 FAS STAT1 TNFSF8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 CD40 CD70 FAS FASLG STAT1 TNFSF8

MGI Mouse Phenotypes related to Acute Myocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 STAT1 TLR3 CD40 CD86 FAS FASLG
2 hematopoietic system MP:0005397 9.8 STAT1 TLR3 CD40 CD70 CD86 FAS
3 homeostasis/metabolism MP:0005376 9.76 STAT1 TLR3 CD40 TNC CD86 FAS
4 immune system MP:0005387 9.56 STAT1 TLR3 CD40 CD70 TNFSF8 CD86
5 nervous system MP:0003631 9.17 STAT1 TLR3 CD40 TNC CD86 FAS

Drugs & Therapeutics for Acute Myocarditis

Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ferrosoferric Oxide Phase 2, Phase 3
2 Hematinics Phase 2, Phase 3
3 Parenteral Nutrition Solutions Phase 2, Phase 3
4 Pharmaceutical Solutions Phase 2, Phase 3
5 Adrenergic Agents Phase 2, Phase 3
6 Adrenergic Antagonists Phase 2, Phase 3
7 Adrenergic beta-Antagonists Phase 2, Phase 3
8 Antirheumatic Agents Phase 2, Phase 3
9 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
10 Neurotransmitter Agents Phase 2, Phase 3
11
Iodine Approved, Investigational Not Applicable 7553-56-2 807
12
Octreotide Approved, Investigational Not Applicable 83150-76-9 383414 6400441
13
Somatostatin Approved, Investigational Not Applicable 38916-34-6, 51110-01-1 53481605
14 cadexomer iodine Not Applicable
15 Antineoplastic Agents, Hormonal Not Applicable
16 Edotreotide Not Applicable
17 Gastrointestinal Agents Not Applicable
18 Hormone Antagonists Not Applicable
19 Hormones Not Applicable
20 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
21 Radiopharmaceuticals Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
2 Anakinra Versus Placebo for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
3 Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFPEF Patients Treated With Allogeneic CDCs Recruiting NCT02941705 Phase 2
4 Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) Active, not recruiting NCT02293603 Phase 1
5 International Myocarditis Registry Unknown status NCT01307735
6 German Centre for Cardiovascular Research Cardiomyopathy Register Unknown status NCT02187263
7 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
8 CMR in Patients With Myocarditis Completed NCT01962584
9 Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis Recruiting NCT02905721 Not Applicable
10 CMR Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance Recruiting NCT03525639 Not Applicable
11 French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRI Recruiting NCT02717143
12 Impella CP With VA ECMO for Cardiogenic Shock Recruiting NCT03431467 Not Applicable
13 Pilot Study Evaluating Somatostatin Receptor's PET Imaging to Detect Inflammatory Phases of Myocarditis Not yet recruiting NCT03347760 Not Applicable DOTATOC-68Ga PET initial;DOTATOC-68Ga PET at 6 months

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

Anatomical Context for Acute Myocarditis

MalaCards organs/tissues related to Acute Myocarditis:

41
Heart, T Cells, Cardiac Myocytes, Liver, Kidney, Myeloid

Publications for Acute Myocarditis

Articles related to Acute Myocarditis:

(show top 50) (show all 506)
# Title Authors Year
1
Acute Myocarditis with Infarct-like Presentation in a Pediatric Population: Role of Cardiovascular Magnetic Resonance. ( 28986648 )
2018
2
RE: Multi-Parameter CMR Approach in Acute Myocarditis to Improve Diagnosis and Prognostic Stratification. ( 29520196 )
2018
3
Acute myocarditis as a revealing clue of complete Kawasaki disease. ( 29976047 )
2018
4
Anthracycline-induced acute myocarditis and ventricular fibrillation arrest. ( 29194712 )
2018
5
Acute myocarditis secondary to acute<i>Campylobacter jejuni</i>infection. ( 29436448 )
2018
6
Acute myocarditis with thrombus near left ventricular outflow tract. ( 29457263 )
2018
7
CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis. ( 29039143 )
2018
8
Vasoactive Intestinal Peptide Ameliorates Acute Myocarditis and Atherosclerosis by Regulating Inflammatory and Autoimmune Responses. ( 29669783 )
2018
9
Incremental value of cardiovascular magnetic resonance feature tracking derived atrial and ventricular strain parameters in a comprehensive approach for the diagnosis of acute myocarditis. ( 29857857 )
2018
10
Electrocardiographic Predictors of Morbidity and Mortality in Patients With Acute Myocarditis: The Importance of QRS-T Angle. ( 29158065 )
2018
11
Ferumoxytol-enhanced magnetic resonance imaging in acute myocarditis. ( 28986407 )
2018
12
Phaeochromocytoma found on cardiovascular magnetic resonance in a patient presenting with acute myocarditis: an unusual association. ( 29884661 )
2018
13
Murine model of acute myocarditis and cerebral cortical neuron edema induced by coxsackievirus B4. ( 29511145 )
2018
14
Diagnostic Accuracy of Cardiovascular Magnetic Resonance in Acute Myocarditis: A Systematic Review and Meta-Analysis. ( 29454761 )
2018
15
Complete Atrioventricular Block Associated with Pembrolizumab-induced Acute Myocarditis: The Need for Close Cardiac Monitoring. ( 29877257 )
2018
16
The search for water: Is it so easy to diagnose acute myocarditis? ( 29435861 )
2018
17
Identifying Non-invasive Tools to Distinguish Acute Myocarditis from Dilated Cardiomyopathy in Children. ( 29651540 )
2018
18
Clinical Presentation and Outcome in a Contemporary Cohort of Patients with Acute Myocarditis: The Multicenter Lombardy Registry. ( 29764898 )
2018
19
T1-mapping provides superior diagnostic accuracy than late gadolinium enhancement imaging in patients with acute myocarditis. ( 29506727 )
2018
20
Changes of late gadolinium enhancement extension compared with native T1 mapping early after acute myocarditis. ( 29506700 )
2018
21
Refractory adult-onset Still disease complicated by macrophage activation syndrome and acute myocarditis: A case report treated with high doses (8a88mg/kg/d) of anakinra. ( 28614216 )
2017
22
Necroptosis may be a novel mechanism for cardiomyocyte death in acute myocarditis. ( 28887702 )
2017
23
Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK. ( 28410530 )
2017
24
A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking. ( 28931401 )
2017
25
Value of SOFA, APACHE IV and SAPS II scoring systems in predicting short-term mortality in patients with acute myocarditis. ( 28968972 )
2017
26
Acute myocarditis secondary to cardiac tuberculosis: a case report. ( 28814447 )
2017
27
Sudden death and acute myocarditis: a unique forensic case of double origin of coronary arteries. ( 28928257 )
2017
28
Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis. ( 28440472 )
2017
29
Predictors of Extracorporeal Membrane Oxygenation Support for Children with Acute Myocarditis. ( 28584814 )
2017
30
Acute Myocarditis Secondary to Reactivated Chromosomally-Integrated Human Herpesvirus 6. ( 28522239 )
2017
31
Assessment of acute myocarditis by cardiac magnetic resonance imaging: Comparison of qualitative and quantitative analysis methods. ( 29076052 )
2017
32
Acute Myocarditis Versus Ventricular Noncompaction Cardiomyopathy in Infancy: Role of Magnetic Resonance. ( 28528884 )
2017
33
Late Detection of Left Ventricular Dysfunction Using Two-Dimensional and Three-Dimensional Speckle-Tracking Echocardiography in Patients with History of Nonsevere Acute Myocarditis. ( 28599827 )
2017
34
Acute Myocarditis Due to Mushroom Ingestion. ( 28860035 )
2017
35
Predictive Value of Cardiac Magnetic Resonance Imaging-Derived Myocardial Strain for Poor Outcomes in Patients with Acute Myocarditis. ( 28670159 )
2017
36
Cardiac MR With Late Gadolinium Enhancement in Acute Myocarditis WithA Preserved Systolic Function: ITAMY Study. ( 29025554 )
2017
37
Myocardial edema in acute myocarditis: relationship of T2 relaxometry and late enhancement burden by using dual-contrast turbo spin-echo MRI. ( 28528429 )
2017
38
Ferumoxytol in acute myocarditis: 'keep your head in the clouds and your feet on the earth'. ( 28780574 )
2017
39
Survival and Left Ventricular Function Changes in Fulminant Versus Nonfulminant Acute Myocarditis. ( 28576783 )
2017
40
Established and novel treatment options in acute myocarditis, with or without heart failure. ( 27858465 )
2017
41
Heart Failure and Mortality of Adult Survivors from Acute Myocarditis Requiring Intensive Care Treatment - A Nationwide Cohort Study. ( 29104480 )
2017
42
Feature-tracking myocardial strain analysis in acute myocarditis: diagnostic value and association with myocardial oedema. ( 28500369 )
2017
43
Contemporary Postnatal Incidence of Acquiring Acute Myocarditis by Age 15 Years and the Outcomes From a Nationwide Birth Cohort. ( 29068909 )
2017
44
Re-evaluation of a novel approach for quantitative myocardial oedema detection by analysing tissue inhomogeneity in acute myocarditis using T2-mapping. ( 28656464 )
2017
45
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. ( 28226202 )
2017
46
Autosomal Recessive Cardiomyopathy Presenting as Acute Myocarditis. ( 28359509 )
2017
47
Left and right ventricular morphology, function and late gadolinium enhancement extent and localization change with different clinical presentation of acute myocarditis Data from the ITAlian multicenter study on MYocarditis (ITAMY). ( 28915139 )
2017
48
Persistent Atrial Standstill in Acute Myocarditis. ( 26897154 )
2016
49
Acute myocarditis in an immunocompetent young man: Don't forget Toxoplasma gondii. ( 27085128 )
2016
50
Clinicodemographic features and outcome of acute myocarditis in children admitted at tertiary care hospital. ( 27400295 )
2016

Variations for Acute Myocarditis

Expression for Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for Acute Myocarditis

Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 CD40 CD70 FAS FASLG STAT1 TNC
2
Show member pathways
13.06 CD40 CD70 CD86 FASLG STAT1 TNFSF8
3
Show member pathways
13.06 CD40 CD70 FAS FASLG STAT1 TLR3
4
Show member pathways
13.04 CD40 CD70 FAS FASLG TNFSF8
5
Show member pathways
12.68 FAS FASLG STAT1 TLR3 TNC
6
Show member pathways
12.67 CD40 CD70 FAS FASLG TNFSF8
7
Show member pathways
12.57 CD40 CD86 FAS FASLG STAT1
8
Show member pathways
12.51 FAS FASLG STAT1 TLR3
9
Show member pathways
12.48 CD40 CD86 FAS FASLG STAT1 TLR3
10 12.31 FAS FASLG STAT1 TLR3
11
Show member pathways
12.26 CD40 FASLG TLR3
12
Show member pathways
12.25 CD40 CD70 FAS FASLG STAT1
13
Show member pathways
12.11 FAS FASLG STAT1
14
Show member pathways
12.07 FAS FASLG TLR3
15
Show member pathways
12.01 CD86 STAT1 TLR3
16
Show member pathways
11.94 FAS FASLG STAT1 TLR3
17
Show member pathways
11.93 FAS FASLG STAT1
18
Show member pathways
11.87 CD86 FAS FASLG STAT1 TLR3
19 11.25 FAS FASLG
20 11.15 FAS FASLG
21 11.11 CD40 CD86
22 10.97 CD70 FASLG TNFSF8
23 10.69 CD40 CD70 CD86 TNFSF8

GO Terms for Acute Myocarditis

Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.43 CD40 CD70 FAS FASLG TLR3 TNFSF8
2 cell surface GO:0009986 9.02 CD40 CD86 FAS FASLG TLR3

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.95 CD70 CD86 FAS FASLG STAT1 TLR3
2 positive regulation of cell proliferation GO:0008284 9.85 CD86 FASLG STAT1 TNC
3 regulation of cell proliferation GO:0042127 9.76 CD40 FAS TNC
4 response to lipopolysaccharide GO:0032496 9.74 CD40 FAS FASLG
5 defense response to virus GO:0051607 9.73 CD40 STAT1 TLR3
6 immune response GO:0006955 9.73 CD40 CD70 CD86 FAS FASLG TNFSF8
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.7 CD40 FASLG TLR3
8 apoptotic signaling pathway GO:0097190 9.62 CD40 FAS FASLG TLR3
9 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.58 FAS FASLG
10 positive regulation of interleukin-12 production GO:0032735 9.54 CD40 TLR3
11 cellular response to mechanical stimulus GO:0071260 9.54 CD40 FAS TLR3
12 positive regulation of endothelial cell apoptotic process GO:2000353 9.51 CD40 FASLG
13 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.49 FAS FASLG
14 necroptotic process GO:0070266 9.48 FASLG TLR3
15 cellular response to interferon-beta GO:0035458 9.46 STAT1 TLR3
16 extrinsic apoptotic signaling pathway GO:0097191 9.46 CD70 FAS FASLG TLR3
17 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.43 FAS FASLG
18 necroptotic signaling pathway GO:0097527 9.13 FAS FASLG TLR3
19 tumor necrosis factor-mediated signaling pathway GO:0033209 9.1 CD40 CD70 FAS FASLG STAT1 TNFSF8

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.5 CD70 FASLG TNFSF8
2 signaling receptor activity GO:0038023 9.26 CD40 CD86 FAS TLR3
3 tumor necrosis factor-activated receptor activity GO:0005031 9.16 CD40 FAS
4 tumor necrosis factor receptor binding GO:0005164 8.92 CD70 FASLG STAT1 TNFSF8
5 protein binding GO:0005515 10 CD40 CD70 CD86 FAS FASLG SDHA

Sources for Acute Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....