MCID: ACT076
MIFTS: 47

Acute Myocarditis

Categories: Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Acute Myocarditis

MalaCards integrated aliases for Acute Myocarditis:

Name: Acute Myocarditis 12 56 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3951
ICD9CM 36 422 422.90
NCIt 51 C35206
SNOMED-CT 69 46701001
ICD10 34 I40 I40.9
UMLS 74 C0155686

Summaries for Acute Myocarditis

MalaCards based summary : Acute Myocarditis is related to myocarditis and systemic lupus erythematosus. An important gene associated with Acute Myocarditis is CD70 (CD70 Molecule), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Pharmaceutical Solutions and Parenteral Nutrition Solutions have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Acute Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 myocarditis 31.6 CD40 CD86 TNNI3
2 systemic lupus erythematosus 28.9 CD40 CD70 CD86 FAS FASLG STAT1
3 giant cell myocarditis 10.8
4 myocardial infarction 10.4
5 acute myocardial infarction 10.3
6 fiedler's myocarditis 10.3
7 septic myocarditis 10.3
8 dilated cardiomyopathy 10.3
9 atrioventricular block 10.2
10 rere-related disorders 10.2
11 sulfamethoxazole allergy 10.2 CD40 CD86
12 penicilliosis 10.2 CD40 CD86
13 third-degree atrioventricular block 10.2
14 exanthema subitum 10.1 CD40 CD86
15 atrial standstill 1 10.1
16 influenza 10.1
17 cardiogenic shock 10.1
18 immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia 10.1 STAT1 TLR3
19 pericarditis 10.1
20 lupus erythematosus 10.1
21 japanese encephalitis 10.1 STAT1 TLR3
22 chronic venous leg ulcers 10.0 FAS FASLG
23 type ii mixed cryoglobulinemia 10.0 FAS FASLG
24 lymphocytic gastritis 10.0 FAS FASLG
25 lymphomatoid papulosis 10.0 FAS FASLG
26 keloids 10.0 FAS TNC
27 cartilage-hair hypoplasia 10.0 FAS FASLG
28 pheochromocytoma 9.9
29 granulomatosis with polyangiitis 9.9
30 malaria 9.9
31 pneumonia 9.9
32 hypereosinophilic syndrome 9.9
33 eosinophilic granulomatosis with polyangiitis 9.9
34 severe cutaneous adverse reaction 9.9 FAS FASLG TLR3
35 ventricular fibrillation, paroxysmal familial, 1 9.9
36 kawasaki disease 9.9
37 hepatitis 9.9
38 muscle disorders 9.9
39 adrenal gland pheochromocytoma 9.9
40 atrial fibrillation 9.9
41 cardiac tamponade 9.9
42 coronary artery vasospasm 9.9
43 adult-onset still's disease 9.9
44 myopathy 9.9
45 pulmonary embolism 9.9
46 diastolic heart failure 9.9
47 hypertrophic cardiomyopathy 9.9
48 broken heart syndrome 9.9
49 hashimoto thyroiditis 9.8 CD40 FAS FASLG
50 central nervous system tuberculosis 9.8 FAS FASLG STAT1

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):


Heart Disease Ischemic Heart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to Acute Myocarditis

Symptoms & Phenotypes for Acute Myocarditis

GenomeRNAi Phenotypes related to Acute Myocarditis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.23 CD70 FAS STAT1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.23 CD40 CD70 FAS FASLG STAT1

MGI Mouse Phenotypes related to Acute Myocarditis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.98 CD86 FAS PRF1 STAT1 TLR3 TNC
2 hematopoietic system MP:0005397 9.97 CD40 CD70 CD86 FAS FASLG PRF1
3 homeostasis/metabolism MP:0005376 9.97 CD40 CD86 FAS FASLG PRF1 SDHA
4 endocrine/exocrine gland MP:0005379 9.95 CD40 CD86 FAS FASLG PRF1 STAT1
5 immune system MP:0005387 9.86 CD40 CD70 CD86 FAS FASLG PRF1
6 nervous system MP:0003631 9.56 CD40 CD86 FAS FASLG PRF1 STAT1
7 neoplasm MP:0002006 9.55 FAS FASLG PRF1 STAT1 TLR3
8 normal MP:0002873 9.1 CD40 FAS FASLG PRF1 STAT1 TNC

Drugs & Therapeutics for Acute Myocarditis

Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2, Phase 3
2 Parenteral Nutrition Solutions Phase 2, Phase 3
3 Ferrosoferric Oxide Phase 2, Phase 3
4 Hematinics Phase 2, Phase 3
5 Adrenergic Antagonists Phase 2, Phase 3
6 Antirheumatic Agents Phase 2, Phase 3
7 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
8 Neurotransmitter Agents Phase 2, Phase 3
9 Adrenergic Agents Phase 2, Phase 3
10 Adrenergic beta-Antagonists Phase 2, Phase 3
11
Iodine Approved, Investigational Not Applicable 7553-56-2 807
12
Octreotide Approved, Investigational Not Applicable 83150-76-9 6400441 383414
13
Somatostatin Approved, Investigational Not Applicable 38916-34-6, 51110-01-1 53481605
14 cadexomer iodine Not Applicable
15 Antineoplastic Agents, Hormonal Not Applicable
16 Hormone Antagonists Not Applicable
17 Gastrointestinal Agents Not Applicable
18 Hormones Not Applicable
19 Edotreotide Not Applicable
20 Radiopharmaceuticals Not Applicable
21 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
2 Anakinra Versus Placebo for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
3 Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFPEF Patients Treated With Allogeneic CDCs Recruiting NCT02941705 Phase 2
4 Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) Active, not recruiting NCT02293603 Phase 1
5 International Myocarditis Registry Unknown status NCT01307735
6 German Centre for Cardiovascular Research Cardiomyopathy Register Unknown status NCT02187263
7 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
8 CMR in Patients With Myocarditis Completed NCT01962584
9 Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis Recruiting NCT02905721 Not Applicable
10 CMR Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance Recruiting NCT03525639 Not Applicable
11 French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRI Recruiting NCT02717143
12 Impella CP With VA ECMO for Cardiogenic Shock Recruiting NCT03431467 Not Applicable
13 Hs-cTnI Diagnosis of NSTE-ACS Patients in China Recruiting NCT03734796
14 Ventricular Arrhythmia After Myocarditis in Sportsman Not yet recruiting NCT03842592 Not Applicable
15 Pilot Study Evaluating Somatostatin Receptor's PET Imaging to Detect Inflammatory Phases of Myocarditis Not yet recruiting NCT03347760 Not Applicable DOTATOC-68Ga PET initial;DOTATOC-68Ga PET at 6 months

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

Anatomical Context for Acute Myocarditis

MalaCards organs/tissues related to Acute Myocarditis:

42
Heart, T Cells, Liver, Cardiac Myocytes, Kidney, Myeloid, B Cells

Publications for Acute Myocarditis

Articles related to Acute Myocarditis:

(show top 50) (show all 556)
# Title Authors Year
1
Two-dimensional and three-dimensional cardiac magnetic resonance feature-tracking myocardial strain analysis in acute myocarditis patients with preserved ejection fraction. ( 30929101 )
2019
2
Prevalence and Significance of an Early Repolarization Electrocardiographic Pattern and Its Mechanistic Insight Based on Cardiac Magnetic Resonance Imaging in Patients With Acute Myocarditis. ( 30879333 )
2019
3
Response by Ammirati et al to Letter Regarding Article, "Clinical Presentation and Outcome in a Contemporary Cohort of Patients With Acute Myocarditis". ( 30865485 )
2019
4
Letter by El-Battrawy et al Regarding Article, "Clinical Presentation and Outcome in a Contemporary Cohort of Patients With Acute Myocarditis". ( 30865476 )
2019
5
Therapeutic Advances in Emergency Cardiology: A Focus on Acute Myocarditis. ( 30839378 )
2019
6
Clinical Value and Prognostic Impact of Pericardial Involvement in Acute Myocarditis. ( 30755055 )
2019
7
Intravenous Immunoglobulin Therapy for Acute Myocarditis in Children and Adults. ( 30745539 )
2019
8
Does myocardial strain remain abnormal long after normalization of ejection fraction in patients with acute myocarditis? ( 30677173 )
2019
9
ACUTE MYOCARDITIS WITH CARDIOGENIC SHOCK AND MULTIPLE ORGAN FAILURE, FOLLOWED BY BILATERAL PANUVEITIS MASQUERADING AS ENDOGENOUS ENDOPHTHALMITIS, DUE TO TOXOPLASMA GONDII IN AN IMMUNOCOMPETENT PATIENT. ( 30664080 )
2019
10
In-hospital and post-discharge outcomes of pediatric acute myocarditis underwent after high-dose steroid or intravenous immunoglobulin therapy. ( 30626332 )
2019
11
B Cells Increase Myocardial Inflammation by Suppressing M2 Macrophage Polarization in Coxsackie Virus B3-Induced Acute Myocarditis. ( 30604194 )
2019
12
Acute Myocarditis and Pericarditis in Children. ( 30600275 )
2019
13
Myocardial Partition Coefficient of Gadolinium: A Pilot Study in Patients With Acute Myocarditis, Chronic Myocardial Infarction, and in Healthy Volunteers. ( 30595183 )
2019
14
Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis. ( 30539745 )
2019
15
Evidence of aldosterone synthesis in human myocardium in acute myocarditis. ( 30384979 )
2019
16
Diagnostic and prognostic role of cardiac magnetic resonance in acute myocarditis. ( 30033478 )
2019
17
A Very Rare Complication of Hepatitis A Infection: Acute Myocarditis-A Case Report with Literature Review. ( 30302093 )
2018
18
Identification of potential pathogenic viruses in patients with acute myocarditis using next-generation sequencing. ( 30011073 )
2018
19
Acute myocarditis with thrombus near left ventricular outflow tract. ( 29457263 )
2018
20
Diagnostic Accuracy of Cardiovascular Magnetic Resonance in Acute Myocarditis: A Systematic Review and Meta-Analysis. ( 29454761 )
2018
21
Acute myocarditis secondary to acute Campylobacter jejuni infection. ( 29436448 )
2018
22
The search for water: Is it so easy to diagnose acute myocarditis? ( 29435861 )
2018
23
Anthracycline-induced acute myocarditis and ventricular fibrillation arrest. ( 29194712 )
2018
24
Electrocardiographic Predictors of Morbidity and Mortality in Patients With Acute Myocarditis: The Importance of QRS-T Angle. ( 29158065 )
2018
25
CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis. ( 29039143 )
2018
26
Acute Myocarditis with Infarct-like Presentation in a Pediatric Population: Role of Cardiovascular Magnetic Resonance. ( 28986648 )
2018
27
Ferumoxytol-enhanced magnetic resonance imaging in acute myocarditis. ( 28986407 )
2018
28
Necroptosis may be a novel mechanism for cardiomyocyte death in acute myocarditis. ( 28887702 )
2018
29
Acute Myocarditis Due to Mushroom Ingestion. ( 28860035 )
2018
30
Ferumoxytol in acute myocarditis: 'keep your head in the clouds and your feet on the earth'. ( 28780574 )
2018
31
Acute Myocarditis Versus Ventricular Noncompaction Cardiomyopathy in Infancy: Role of Magnetic Resonance. ( 28528884 )
2018
32
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. ( 28226202 )
2018
33
Silent acute myocarditis in eosinophilic granulomatosis with polyangiitis. ( 30641540 )
2018
34
Desmoplakin Variant-Associated Arrhythmogenic Cardiomyopathy Presenting as Acute Myocarditis. ( 30562115 )
2018
35
Tyrosine Kinase Inhibitor-Induced Acute Myocarditis, Myositis, and Cardiogenic Shock. ( 30410662 )
2018
36
Left ventricular endocardial longitudinal dysfunction persists after acute myocarditis with preserved ejection fraction. ( 30315606 )
2018
37
Impact of atrial fibrillation on patients hospitalized for acute myocarditis: Insights from a nationally-representative United States cohort. ( 30284301 )
2018
38
Prevalence and Prognostic Impact of Septal Late Gadolinium Enhancement in Acute Myocarditis With or Without Preserved Left Ventricular Function. ( 30266253 )
2018
39
The diagnostic challenge: Takotsubo cardiomyopathy vs. acute myocarditis. ( 30170778 )
2018
40
The unique role of cardiovascular magnetic resonance imaging in acute myocarditis. ( 30109023 )
2018
41
Cardiac MRI Texture Analysis of T1 and T2 Maps in Patients with Infarctlike Acute Myocarditis. ( 30084736 )
2018
42
Role of right ventricular involvement in acute myocarditis, assessed by cardiac magnetic resonance. ( 30045820 )
2018
43
Left and right ventricular strain in the course of acute myocarditis: a cardiovascular magnetic resonance study. ( 30045397 )
2018
44
Reversible impairment of coronary flow reserve in acute myocarditis. ( 30027659 )
2018
45
Diagnostic Performance of Extracellular Volume, Native T1, and T2 Mapping Versus Lake Louise Criteria by Cardiac Magnetic Resonance for Detection of Acute Myocarditis: A Meta-Analysis. ( 30012826 )
2018
46
Acute myocarditis as a revealing clue of complete Kawasaki disease. ( 29976047 )
2018
47
Phaeochromocytoma found on cardiovascular magnetic resonance in a patient presenting with acute myocarditis: an unusual association. ( 29884661 )
2018
48
Complete Atrioventricular Block Associated with Pembrolizumab-induced Acute Myocarditis: The Need for Close Cardiac Monitoring. ( 29877257 )
2018
49
Incremental value of cardiovascular magnetic resonance feature tracking derived atrial and ventricular strain parameters in a comprehensive approach for the diagnosis of acute myocarditis. ( 29857857 )
2018
50
Clinical Presentation and Outcome in a Contemporary Cohort of Patients With Acute Myocarditis. ( 29764898 )
2018

Variations for Acute Myocarditis

Expression for Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for Acute Myocarditis

Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 CD40 CD70 FAS FASLG STAT1 TLR3
2
Show member pathways
13.1 CD40 CD70 CD86 FASLG STAT1
3
Show member pathways
12.67 CD40 CD70 FAS FASLG
4
Show member pathways
12.67 CD86 FAS FASLG STAT1 TLR3
5
Show member pathways
12.67 FAS FASLG STAT1 TLR3 TNC
6
Show member pathways
12.54 CD70 FAS FASLG PRF1
7
Show member pathways
12.37 CD40 CD86 FAS FASLG STAT1 TLR3
8 12.27 FAS FASLG STAT1 TLR3
9
Show member pathways
12.19 CD40 CD70 FAS FASLG TLR3
10
Show member pathways
12.15 CD40 CD70 FAS FASLG STAT1
11
Show member pathways
12.08 FAS FASLG STAT1
12
Show member pathways
12.04 FAS FASLG TLR3
13
Show member pathways
12.03 FAS FASLG PRF1
14
Show member pathways
11.92 FAS FASLG STAT1
15
Show member pathways
11.86 FAS FASLG STAT1 TLR3
16
Show member pathways
11.84 CD40 CD86 FAS FASLG PRF1 STAT1
17
Show member pathways
11.8 CD86 STAT1 TLR3
18
Show member pathways
11.5 FAS FASLG PRF1
19 11.31 CD40 CD70 CD86
20 11.25 FAS FASLG
21 11.15 FAS FASLG
22 11.09 CD40 CD86
23 11.02 CD70 FASLG

GO Terms for Acute Myocarditis

Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 CD40 CD86 FAS FASLG TLR3

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.99 CD70 CD86 FAS FASLG STAT1 TLR3
2 positive regulation of cell proliferation GO:0008284 9.85 TNC CD86 FASLG STAT1
3 immune response GO:0006955 9.8 CD70 CD86 FAS FASLG
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.71 CD40 FASLG TLR3
5 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.56 FAS FASLG
6 defense response to virus GO:0051607 9.56 CD40 PRF1 STAT1 TLR3
7 cellular response to mechanical stimulus GO:0071260 9.54 CD40 FAS TLR3
8 positive regulation of interleukin-12 production GO:0032735 9.52 CD40 TLR3
9 apoptotic signaling pathway GO:0097190 9.5 FAS FASLG TLR3
10 positive regulation of endothelial cell apoptotic process GO:2000353 9.48 CD40 FASLG
11 cellular response to interferon-beta GO:0035458 9.46 STAT1 TLR3
12 tumor necrosis factor-mediated signaling pathway GO:0033209 9.46 CD40 CD70 FASLG STAT1
13 necroptotic process GO:0070266 9.43 FASLG TLR3
14 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.4 FAS FASLG
15 extrinsic apoptotic signaling pathway GO:0097191 9.26 FAS CD70 FASLG TLR3
16 necroptotic signaling pathway GO:0097527 8.8 TLR3 FASLG FAS

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.9 CD40 CD70 CD86 FAS FASLG PRF1
2 signaling receptor activity GO:0038023 9.26 CD40 CD86 FAS TLR3
3 tumor necrosis factor receptor binding GO:0005164 8.8 CD70 FASLG STAT1

Sources for Acute Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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