MCID: ACT076
MIFTS: 47

Acute Myocarditis

Categories: Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Acute Myocarditis

MalaCards integrated aliases for Acute Myocarditis:

Name: Acute Myocarditis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3951
ICD10 33 I40 I40.9
ICD9CM 35 422 422.90
NCIt 50 C35206
SNOMED-CT 68 46701001
UMLS 73 C0155686

Summaries for Acute Myocarditis

MalaCards based summary : Acute Myocarditis is related to myocarditis and systemic lupus erythematosus. An important gene associated with Acute Myocarditis is TLR3 (Toll Like Receptor 3), and among its related pathways/superpathways are ERK Signaling and Cytokine Signaling in Immune system. The drugs Parenteral Nutrition Solutions and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Acute Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 myocarditis 31.4 CD40 CD86 TNNI3
2 systemic lupus erythematosus 29.1 CD40 CD70 CD86 FAS FASLG STAT1
3 giant cell myocarditis 10.8
4 myocardial infarction 10.4
5 acute myocardial infarction 10.3
6 fiedler's myocarditis 10.3
7 septic myocarditis 10.3
8 dilated cardiomyopathy 10.3
9 atrioventricular block 10.2
10 sulfamethoxazole allergy 10.1 CD40 CD86
11 influenza 10.1
12 penicilliosis 10.1 CD40 CD86
13 exanthema subitum 10.1 CD40 CD86
14 cardiogenic shock 10.1
15 immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia 10.0 STAT1 TLR3
16 lupus erythematosus 10.0
17 keloids 10.0 FAS TNC
18 japanese encephalitis 10.0 STAT1 TLR3
19 atrial standstill 1 10.0
20 pericarditis 10.0
21 chronic venous leg ulcers 10.0 FAS FASLG
22 type ii mixed cryoglobulinemia 10.0 FAS FASLG
23 lymphocytic gastritis 10.0 FAS FASLG
24 lymphomatoid papulosis 9.9 FAS FASLG
25 cartilage-hair hypoplasia 9.9 FAS FASLG
26 pheochromocytoma 9.9
27 cardiomyopathy, familial hypertrophic, 1 9.9
28 malaria 9.9
29 pneumonia 9.9
30 viral infectious disease 9.9
31 severe cutaneous adverse reaction 9.9 FAS FASLG TLR3
32 hashimoto thyroiditis 9.9 CD40 FAS FASLG
33 common variable immunodeficiency 9.8 CD40 CD70 CD86 FAS
34 graves' disease 9.8 CD40 FAS FASLG
35 ventricular fibrillation, paroxysmal familial, 1 9.8
36 granulomatosis with polyangiitis 9.8
37 kawasaki disease 9.8
38 hepatitis 9.8
39 atrial fibrillation 9.8
40 cardiac tamponade 9.8
41 coronary artery vasospasm 9.8
42 myopathy 9.8
43 pulmonary embolism 9.8
44 diastolic heart failure 9.8
45 hypertrophic cardiomyopathy 9.8
46 epstein-barr virus-associated gastric carcinoma 9.8 FAS FASLG
47 central nervous system tuberculosis 9.8 FAS FASLG STAT1
48 lymphoma, non-hodgkin, familial 9.8 CD40 CD70 FAS TNFSF8
49 familial isolated dilated cardiomyopathy 9.7 SDHA TNNI3
50 myositis 9.7

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):


Heart Disease Ischemic Heart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to Acute Myocarditis

Symptoms & Phenotypes for Acute Myocarditis

GenomeRNAi Phenotypes related to Acute Myocarditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 CD70 FAS STAT1 TNFSF8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 CD40 CD70 FAS FASLG STAT1 TNFSF8

MGI Mouse Phenotypes related to Acute Myocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 CD40 CD86 FAS FASLG STAT1 TLR3
2 hematopoietic system MP:0005397 9.8 CD40 CD70 CD86 FAS FASLG STAT1
3 homeostasis/metabolism MP:0005376 9.76 CD40 CD86 FAS FASLG SDHA STAT1
4 immune system MP:0005387 9.56 CD40 CD70 CD86 FAS FASLG STAT1
5 nervous system MP:0003631 9.17 CD40 CD86 FAS FASLG STAT1 TLR3

Drugs & Therapeutics for Acute Myocarditis

Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Parenteral Nutrition Solutions Phase 2, Phase 3
2 Hematinics Phase 2, Phase 3
3 Pharmaceutical Solutions Phase 2, Phase 3
4 Ferrosoferric Oxide Phase 2, Phase 3
5 Neurotransmitter Agents Phase 2, Phase 3
6 Adrenergic beta-Antagonists Phase 2, Phase 3
7 Adrenergic Antagonists Phase 2, Phase 3
8 Adrenergic Agents Phase 2, Phase 3
9 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
10 Antirheumatic Agents Phase 2, Phase 3
11
Iodine Approved, Investigational Not Applicable 7553-56-2 807
12
Octreotide Approved, Investigational Not Applicable 83150-76-9 383414 6400441
13
Somatostatin Approved, Investigational Not Applicable 51110-01-1, 38916-34-6 53481605
14 cadexomer iodine Not Applicable
15 Antineoplastic Agents, Hormonal Not Applicable
16 Edotreotide Not Applicable
17 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
18 Radiopharmaceuticals Not Applicable
19 Hormones Not Applicable
20 Hormone Antagonists Not Applicable
21 Gastrointestinal Agents Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
2 Anakinra Versus Placebo for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
3 Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFPEF Patients Treated With Allogeneic CDCs Recruiting NCT02941705 Phase 2
4 Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) Active, not recruiting NCT02293603 Phase 1
5 International Myocarditis Registry Unknown status NCT01307735
6 German Centre for Cardiovascular Research Cardiomyopathy Register Unknown status NCT02187263
7 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
8 CMR in Patients With Myocarditis Completed NCT01962584
9 Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis Recruiting NCT02905721 Not Applicable
10 CMR Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance Recruiting NCT03525639 Not Applicable
11 French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRI Recruiting NCT02717143
12 Impella CP With VA ECMO for Cardiogenic Shock Recruiting NCT03431467 Not Applicable
13 Hs-cTnI Diagnosis of NSTE-ACS Patients in China Recruiting NCT03734796
14 Pilot Study Evaluating Somatostatin Receptor's PET Imaging to Detect Inflammatory Phases of Myocarditis Not yet recruiting NCT03347760 Not Applicable DOTATOC-68Ga PET initial;DOTATOC-68Ga PET at 6 months

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

Anatomical Context for Acute Myocarditis

MalaCards organs/tissues related to Acute Myocarditis:

41
Heart, T Cells, Liver, Cardiac Myocytes, Kidney, Myeloid, Thyroid

Publications for Acute Myocarditis

Articles related to Acute Myocarditis:

(show top 50) (show all 542)
# Title Authors Year
1
Evidence of aldosterone synthesis in human myocardium in acute myocarditis. ( 30384979 )
2019
2
Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis. ( 30539745 )
2019
3
Acute Myocarditis with Infarct-like Presentation in a Pediatric Population: Role of Cardiovascular Magnetic Resonance. ( 28986648 )
2018
4
RE: Multi-Parameter CMR Approach in Acute Myocarditis to Improve Diagnosis and Prognostic Stratification. ( 29520196 )
2018
5
Acute myocarditis as a revealing clue of complete Kawasaki disease. ( 29976047 )
2018
6
Anthracycline-induced acute myocarditis and ventricular fibrillation arrest. ( 29194712 )
2018
7
Acute myocarditis secondary to acute<i>Campylobacter jejuni</i>infection. ( 29436448 )
2018
8
Acute myocarditis with thrombus near left ventricular outflow tract. ( 29457263 )
2018
9
CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis. ( 29039143 )
2018
10
Vasoactive Intestinal Peptide Ameliorates Acute Myocarditis and Atherosclerosis by Regulating Inflammatory and Autoimmune Responses. ( 29669783 )
2018
11
Incremental value of cardiovascular magnetic resonance feature tracking derived atrial and ventricular strain parameters in a comprehensive approach for the diagnosis of acute myocarditis. ( 29857857 )
2018
12
Electrocardiographic Predictors of Morbidity and Mortality in Patients With Acute Myocarditis: The Importance of QRS-T Angle. ( 29158065 )
2018
13
Ferumoxytol-enhanced magnetic resonance imaging in acute myocarditis. ( 28986407 )
2018
14
Letter by Jin-shan and Xue-bin Regarding Article, &amp;quot;Survival and Left Ventricular Function Changes in Fulminant Versus Nonfulminant Acute Myocarditis&amp;quot;. ( 29581376 )
2018
15
Response by Ammirati et al to Letter Regarding Article, &amp;quot;Survival and Left Ventricular Function Changes in Fulminant Versus Nonfulminant Acute Myocarditis&amp;quot;. ( 29581377 )
2018
16
Phaeochromocytoma found on cardiovascular magnetic resonance in a patient presenting with acute myocarditis: an unusual association. ( 29884661 )
2018
17
Murine model of acute myocarditis and cerebral cortical neuron edema induced by coxsackievirus B4. ( 29511145 )
2018
18
Diagnostic Accuracy of Cardiovascular Magnetic Resonance in Acute Myocarditis: A Systematic Review and Meta-Analysis. ( 29454761 )
2018
19
Complete Atrioventricular Block Associated with Pembrolizumab-induced Acute Myocarditis: The Need for Close Cardiac Monitoring. ( 29877257 )
2018
20
The search for water: Is it so easy to diagnose acute myocarditis? ( 29435861 )
2018
21
Identifying Non-invasive Tools to Distinguish Acute Myocarditis from Dilated Cardiomyopathy in Children. ( 29651540 )
2018
22
Clinical Presentation and Outcome in a Contemporary Cohort of Patients with Acute Myocarditis: The Multicenter Lombardy Registry. ( 29764898 )
2018
23
T1-mapping provides superior diagnostic accuracy than late gadolinium enhancement imaging in patients with acute myocarditis. ( 29506727 )
2018
24
Changes of late gadolinium enhancement extension compared with native T1 mapping early after acute myocarditis. ( 29506700 )
2018
25
Identification of potential pathogenic viruses in patients with acute myocarditis using next-generation sequencing. ( 30011073 )
2018
26
Diagnostic Performance of Extracellular Volume, Native T1, and T2 Mapping Versus Lake Louise Criteria by Cardiac Magnetic Resonance for Detection of Acute Myocarditis: A Meta-Analysis. ( 30012826 )
2018
27
Reversible impairment of coronary flow reserve in acute myocarditis. ( 30027659 )
2018
28
Diagnostic and prognostic role of cardiac magnetic resonance in acute myocarditis. ( 30033478 )
2018
29
Left and right ventricular strain in the course of acute myocarditis: a cardiovascular magnetic resonance study. ( 30045397 )
2018
30
Role of right ventricular involvement in acute myocarditis, assessed by cardiac magnetic resonance. ( 30045820 )
2018
31
Cardiac MRI Texture Analysis of T1 and T2 Maps in Patients with Infarctlike Acute Myocarditis. ( 30084736 )
2018
32
The unique role of cardiovascular magnetic resonance imaging in acute myocarditis. ( 30109023 )
2018
33
The diagnostic challenge: Takotsubo cardiomyopathy vs. acute myocarditis. ( 30170778 )
2018
34
Prevalence and Prognostic Impact of Septal Late Gadolinium Enhancement in Acute Myocarditis With or Without Preserved Left Ventricular Function. ( 30266253 )
2018
35
Impact of Atrial Fibrillation on patients hospitalized for Acute Myocarditis: Insights from a nationally-representative United States cohort. ( 30284301 )
2018
36
A Very Rare Complication of Hepatitis A Infection: Acute Myocarditis-A Case Report with Literature Review. ( 30302093 )
2018
37
Left ventricular endocardial longitudinal dysfunction persists after acute myocarditis with preserved ejection fraction. ( 30315606 )
2018
38
Tyrosine Kinase Inhibitor-Induced Acute Myocarditis, Myositis, and Cardiogenic Shock. ( 30410662 )
2018
39
Refractory adult-onset Still disease complicated by macrophage activation syndrome and acute myocarditis: A case report treated with high doses (8a88mg/kg/d) of anakinra. ( 28614216 )
2017
40
Necroptosis may be a novel mechanism for cardiomyocyte death in acute myocarditis. ( 28887702 )
2017
41
Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK. ( 28410530 )
2017
42
A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking. ( 28931401 )
2017
43
Value of SOFA, APACHE IV and SAPS II scoring systems in predicting short-term mortality in patients with acute myocarditis. ( 28968972 )
2017
44
Acute myocarditis secondary to cardiac tuberculosis: a case report. ( 28814447 )
2017
45
Sudden death and acute myocarditis: a unique forensic case of double origin of coronary arteries. ( 28928257 )
2017
46
Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis. ( 28440472 )
2017
47
Predictors of Extracorporeal Membrane Oxygenation Support for Children with Acute Myocarditis. ( 28584814 )
2017
48
Acute Myocarditis Secondary to Reactivated Chromosomally-Integrated Human Herpesvirus 6. ( 28522239 )
2017
49
Assessment of acute myocarditis by cardiac magnetic resonance imaging: Comparison of qualitative and quantitative analysis methods. ( 29076052 )
2017
50
Acute Myocarditis Versus Ventricular Noncompaction Cardiomyopathy in Infancy: Role of Magnetic Resonance. ( 28528884 )
2017

Variations for Acute Myocarditis

Expression for Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for Acute Myocarditis

Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 CD40 CD70 FAS FASLG STAT1 TNC
2
Show member pathways
13.06 CD40 CD70 CD86 FASLG STAT1 TNFSF8
3
Show member pathways
13.05 CD40 CD70 FAS FASLG TNFSF8
4
Show member pathways
13.01 CD40 CD70 FAS FASLG STAT1 TLR3
5
Show member pathways
12.81 CD86 FAS FASLG STAT1 TLR3
6
Show member pathways
12.7 FAS FASLG STAT1 TLR3 TNC
7
Show member pathways
12.65 CD40 CD70 FAS FASLG TNFSF8
8
Show member pathways
12.57 CD40 CD86 FAS FASLG STAT1
9
Show member pathways
12.54 FAS FASLG STAT1 TLR3
10
Show member pathways
12.48 CD40 CD86 FAS FASLG STAT1 TLR3
11
Show member pathways
12.36 CD40 CD70 FAS FASLG STAT1
12 12.33 FAS FASLG STAT1 TLR3
13
Show member pathways
12.13 FAS FASLG STAT1
14
Show member pathways
12.09 FAS FASLG TLR3
15 12.08 CD40 FAS STAT1
16
Show member pathways
11.96 CD40 CD70 FAS FASLG TLR3 TNFSF8
17
Show member pathways
11.95 FAS FASLG STAT1
18
Show member pathways
11.94 FAS FASLG STAT1 TLR3
19
Show member pathways
11.83 CD86 STAT1 TLR3
20 11.27 FAS FASLG
21 11.17 FAS FASLG
22 11.13 CD40 CD86
23 10.98 CD70 FASLG TNFSF8
24 10.91 CD70 FASLG TNFSF8
25 10.79 CD70 FASLG TNC TNFSF8
26 10.69 CD40 CD70 CD86 TNFSF8

GO Terms for Acute Myocarditis

Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.55 CD40 CD70 FASLG TLR3 TNFSF8
2 extracellular space GO:0005615 9.43 CD40 CD70 FASLG TLR3 TNC TNFSF8
3 cell surface GO:0009986 9.02 CD40 CD86 FAS FASLG TLR3

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.91 CD70 CD86 FAS FASLG STAT1 TLR3
2 positive regulation of cell proliferation GO:0008284 9.85 CD86 FASLG STAT1 TNC
3 cell-cell signaling GO:0007267 9.74 CD70 FASLG TNFSF8
4 defense response to virus GO:0051607 9.71 CD40 STAT1 TLR3
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.7 CD40 FASLG TLR3
6 immune response GO:0006955 9.65 CD70 CD86 FAS FASLG TNFSF8
7 cellular response to mechanical stimulus GO:0071260 9.58 CD40 FAS TLR3
8 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.56 FAS FASLG
9 positive regulation of interleukin-12 production GO:0032735 9.51 CD40 TLR3
10 apoptotic signaling pathway GO:0097190 9.5 FAS FASLG TLR3
11 positive regulation of endothelial cell apoptotic process GO:2000353 9.49 CD40 FASLG
12 cellular response to interferon-beta GO:0035458 9.48 STAT1 TLR3
13 necroptotic process GO:0070266 9.46 FASLG TLR3
14 extrinsic apoptotic signaling pathway GO:0097191 9.46 CD70 FAS FASLG TLR3
15 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.43 FAS FASLG
16 necroptotic signaling pathway GO:0097527 9.13 FAS FASLG TLR3
17 tumor necrosis factor-mediated signaling pathway GO:0033209 9.02 CD40 CD70 FASLG STAT1 TNFSF8

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 CD70 FASLG TNFSF8
2 signaling receptor activity GO:0038023 9.26 CD40 CD86 FAS TLR3
3 tumor necrosis factor receptor binding GO:0005164 8.92 CD70 FASLG STAT1 TNFSF8

Sources for Acute Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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