MCID: ACT076
MIFTS: 47

Acute Myocarditis

Categories: Cardiovascular diseases, Immune diseases, Infectious diseases, Muscle diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Acute Myocarditis

MalaCards integrated aliases for Acute Myocarditis:

Name: Acute Myocarditis 12 54 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:3951
ICD9CM 34 422
NCIt 50 C35206
SNOMED-CT 67 155336004
ICD10 32 I40 I40.9
UMLS 71 C0155686

Summaries for Acute Myocarditis

MalaCards based summary : Acute Myocarditis is related to toxic myocarditis and septic myocarditis. An important gene associated with Acute Myocarditis is TLR3 (Toll Like Receptor 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Adrenergic beta-Antagonists and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and cardiac myocytes, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Acute Myocarditis

Diseases in the Myocarditis family:

Autoimmune Myocarditis Acute Myocarditis
Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 634)
# Related Disease Score Top Affiliating Genes
1 toxic myocarditis 31.8 TNNI3 NPPB ACE
2 septic myocarditis 31.5 TNNI3 IL10
3 cardiogenic shock 31.0 TNF NPPB
4 atrioventricular block 30.9 TNNI3 NPPB ACE
5 hemopericardium 30.8 TNNI3 CRP
6 atrial standstill 1 30.2 TNNT2 TNNI3 NPPB ACE
7 anteroseptal myocardial infarction 30.2 MB ACE
8 myocarditis 30.1 TXN TNNI3 TNF TLR3 NPPB MB
9 right bundle branch block 30.0 TNNI3 NPPB ACE
10 diastolic heart failure 30.0 TNNI3 NPPB ACE
11 cardiac tamponade 30.0 TNNI3 NPPB CRP ACE
12 coronary artery vasospasm 30.0 TNNI3 CRP ACE
13 covid-19 30.0 TNNI3 STAT1 NPPB ACE
14 pericardial effusion 29.9 TNNI3 NPPB CRP CD4 ACE
15 conjunctivitis 29.8 TNF TLR3 IL10
16 urinary tract infection 29.8 CRP ACE
17 inferior myocardial infarction 29.8 TNNI3 NPPB ACE
18 coronary stenosis 29.8 TNNI3 NPPB CRP ACE
19 cardiac arrest 29.8 TNNT2 TNNI3 NPPB ACE
20 lupus erythematosus 29.8 TNF IL10 FASLG CD86 CD40
21 chlamydia 29.8 TNF IL10 CRP
22 epidural abscess 29.8 CRP CD4
23 tonsillitis 29.8 TNF TLR3 IL10
24 enterocolitis 29.7 TNF IL10 CRP
25 toxoplasmosis 29.7 TNF STAT1 IL10 CD40
26 cardiac tuberculosis 29.7 NPPB CRP ACE
27 first-degree atrioventricular block 29.7 NPPB CRP ACE
28 rubella 29.7 TNF TLR3 IL10
29 mumps 29.6 TNF TLR3 STAT1 IL10
30 granulomatosis with polyangiitis 29.6 TNF CRP CD86 CD4
31 histoplasmosis 29.6 TNF STAT1 CD4
32 acute myocardial infarction 29.6 TNNT2 TNNI3 NPPB MB CRP ACE
33 leptospirosis 29.6 TNF IL10 CRP
34 severe acute respiratory syndrome 29.5 TNF STAT1 IL10 CRP ACE
35 dengue hemorrhagic fever 29.4 TNF TLR3 STAT1 IL10
36 poliomyelitis 29.4 TNF TLR3 IL10 CD4
37 toxic shock syndrome 29.4 TNF IL10 CRP CD86 CD40
38 mononeuritis multiplex 29.4 TNF CRP CD4 ACE
39 hepatitis a 29.4 TNF TLR3 IL10 CD4
40 dengue disease 29.4 TNF IL10 H2AC18
41 sarcoidosis 1 29.4 TNF STAT1 CRP CD86 CD4 ACE
42 scrub typhus 29.3 TNF IL10 CRP
43 restrictive cardiomyopathy 29.3 TNNT2 TNNI3 NPPB ACE
44 erythema nodosum 29.3 TNF IL10 CRP
45 appendicitis 29.3 TNF IL10 CRP
46 angina pectoris 29.3 TNNI3 NPPB MB CRP ACE
47 chagas disease 29.3 TNF NPPB IL10 CD4 ACE
48 rheumatic myocarditis 29.3 TNNT2 TNNI3 MB CRP
49 pancytopenia 29.3 H2AC18 CRP CD4 ACE
50 gas gangrene 29.3 TNNT2 TNNI3 MB CRP

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to Acute Myocarditis

Symptoms & Phenotypes for Acute Myocarditis

MGI Mouse Phenotypes related to Acute Myocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 ACE CD4 CD40 CD86 CRP FAS
2 cardiovascular system MP:0005385 10.2 ACE CRP FAS FASLG IL10 MB
3 hematopoietic system MP:0005397 10.18 ACE CD4 CD40 CD70 CD86 FAS
4 endocrine/exocrine gland MP:0005379 10.13 ACE CD4 CD40 CD86 FAS FASLG
5 immune system MP:0005387 10.1 ACE CD4 CD40 CD70 CD86 CRP
6 muscle MP:0005369 9.91 CD86 FAS IL10 MB STAT1 TLR3
7 nervous system MP:0003631 9.73 ACE CD4 CD40 CD86 FAS FASLG
8 neoplasm MP:0002006 9.7 ACE FAS FASLG IL10 STAT1 TLR3
9 respiratory system MP:0005388 9.23 FAS FASLG IL10 MB STAT1 TLR3

Drugs & Therapeutics for Acute Myocarditis

Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Adrenergic beta-Antagonists Phase 2, Phase 3
2 Antirheumatic Agents Phase 2, Phase 3
3 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
4
Iodine Approved, Investigational 7553-56-2 807
5
Somatostatin Approved, Investigational 51110-01-1, 38916-34-6 53481605
6
4-Aminopyridine Approved 504-24-5 1727
7
Cadexomer iodine Experimental 94820-09-4
8 Radiopharmaceuticals
9 Edotreotide
10 Fluorodeoxyglucose F18

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Anakinra Versus Placebo Double Blind Randomized Controlled Trial for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
2 DZHK TranslatiOnal Registry for CardiomyopatHies Deutsches Zentrum für Herz- Und Kreislauf-Forschung (DZHK) Unknown status NCT02187263
3 Prospective Assessment of the Clinical Utility of Cardiovascular Magnetic Resonance in Patients With Suspected Acute Myocarditis - A Pilot Study for Establishing an International Registry Unknown status NCT01307735
4 Value of CMR Including T1 Mapping in Patients With Acute Myocarditis Completed NCT01962584
5 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
6 Role of Electrocardiograms in Risk Stratification and Analysis of the Characteristics of ST Elevation in Acute Myocarditis: A Two-center Study Completed NCT04498494
7 Cardiac Magnetic Resonance Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance Recruiting NCT03525639
8 Hospital Registry of Acute Myocarditis: Evolution of the Proportion of Positive SARS-COV-2 Cases During the Covid-19 Pandemic, Case Characteristics and Prognoses Recruiting NCT04375748
9 Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis Recruiting NCT02905721
10 Somatostatin Receptor Imaging in Inflammatory Heart Disease Recruiting NCT04206163
11 Recurrent Acute Myocarditis : Characteristics, Etiology, Prognosis and Genetic Basis. Recruiting NCT04589156
12 Evaluation of Long-term Incidence of Ventricular Arrhythmias in Patients With Acute Myocarditis Recruiting NCT04264455
13 Quantification of Ventricular Arrhythmia After Myocarditis in Sportsman Not yet recruiting NCT03842592
14 Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children Not yet recruiting NCT04420468

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

Anatomical Context for Acute Myocarditis

MalaCards organs/tissues related to Acute Myocarditis:

40
Heart, T Cells, Cardiac Myocytes, Kidney, Myeloid, B Cells, Endothelial

Publications for Acute Myocarditis

Articles related to Acute Myocarditis:

(show top 50) (show all 1750)
# Title Authors PMID Year
1
Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy. 61 54
17322629 2007
2
Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis. 61 54
15685595 2005
3
Redox regulation by thioredoxin in cardiovascular diseases. 54 61
14588153 2003
4
Vagus nerve plays a pivotal role in CD4+ T cell differentiation during CVB3-induced murine acute myocarditis. 61
33380272 2021
5
Potential Mechanisms of Cardiac Injury and Common Pathways of Inflammation in Patients With COVID-19. 61
32467423 2021
6
Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection. 61
33523326 2021
7
Rapid Response to Cytokine Storm Inhibition Using Anakinra in a Patient With COVID-19 Myocarditis. 61
33073222 2021
8
Acute Myocarditis Complicating Systemic Lupus Erythematosus: Detection and Evolution of Transmural Spiral Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging. 61
33586448 2021
9
Cardiac Manifestations, Treatment Characteristics, and Outcomes of Paediatric Inflammatory Multisystem Syndrome Temporally Associated with Severe Acute Respiratory Syndrome Coronavirus-2: systematic review of case reports and case series. 61
33584087 2021
10
Coronavirus Disease 2019 Acute Myocarditis and Multisystem Inflammatory Syndrome in Adult Intensive and Cardiac Care Units. 61
32910974 2021
11
Dynamics in myocardial deformation as an indirect marker of myocardial involvement in acute myocarditis due to HIV infection: a case report. 61
33598608 2021
12
Immune cell infiltration landscapes in pediatric acute myocarditis analyzed by CIBERSORT. 61
32891480 2021
13
Dual-energy cardiac computed tomography: the 'one-stop-shop' for acute myocarditis. 61
32607587 2021
14
Could CMR Tissue-Tracking and Parametric Mapping Distinguish Between Takotsubo Syndrome and Acute Myocarditis? A Pilot Study. 61
33487539 2021
15
The Diagnosis of Acute Myocarditis in Emergency (DAME) score: improving diagnostics within the emergency department. 61
33504460 2021
16
Cardiac involvement in consecutive elite athletes recovered from Covid-19: A magnetic resonance study. 61
33474768 2021
17
Myocardial injury in severe COVID-19: Identification and management. 61
33450334 2021
18
Characteristics and Outcomes of Patients 80 Years and Older Hospitalized With Coronavirus Disease 2019 (COVID-19). 61
33136582 2021
19
Prognostic Role of Left Ventricular Intramyocardial Fatty Metaplasia in Patients With Previous Myocarditis (MYOFAT Study). 61
33352209 2021
20
Functional capacity and rehabilitation strategies in Covid-19 patients: current knowledge and challenges. 61
33533821 2021
21
Comparison of 3D and 2D late gadolinium enhancement magnetic resonance imaging in patients with acute and chronic myocarditis. 61
32793996 2021
22
Cardiac MRI and Myocardial Injury in COVID-19: Diagnosis, Risk Stratification and Prognosis. 61
33467705 2021
23
Prognostic Impact of Late Gadolinium Enhancement by Cardiovascular Magnetic Resonance in Myocarditis: A Systematic Review and Meta-Analysis. 61
33441003 2021
24
[ANMCO/SIC Consensus document on the management of myocarditis]. 61
33231216 2020
25
Cardiac MRI in Children with Multisystem Inflammatory Syndrome Associated with COVID-19. 61
32515676 2020
26
Relapse of acute myocarditis associated with Campylobacter jejuni enterocolitis. 61
33363788 2020
27
Extracorporeal Cardiopulmonary Resuscitation in Acute Fulminant Myocarditis: A Case Report and Review of the Literature. 61
33133749 2020
28
Electrocardiographic features of 431 consecutive, critically ill COVID-19 patients: an insight into the mechanisms of cardiac involvement. 61
32944767 2020
29
Acute myocarditis: phenocopy of apical hypertrophic cardiomyopathy. 61
32792310 2020
30
[SARS-COV-2 myocarditis. An update]. 61
33069383 2020
31
Evolution of acute myocarditis in a pediatric population: An MRI based study. 61
33359333 2020
32
The diagnostic capability of electrocardiography on the cardiogenic shock in the patients with acute myocarditis. 61
33256622 2020
33
Recurrent Elevation of Troponin Levels in Acute Myocarditis: Is it a Sign of Ventricular Tachycardia? 61
32617745 2020
34
[IRM et myocardite infectieuse]. 61
33069385 2020
35
Cerebral embolism due to left atrial myxoma in a patient presenting with chest pain and ST-segment elevation: a case report. 61
33442627 2020
36
Persistence of Late Gadolinium Enhancement on Follow-Up CMR Imaging in Children with Acute Myocarditis. 61
32920654 2020
37
Acute Myocarditis After Black Widow Spider Bite: A Case Report. 61
32462634 2020
38
Pediatric Acute Myocarditis: Current Approach to Diagnosis and Treatment. 61
33118335 2020
39
CARD9 mediates T cell inflammatory response in Coxsackievirus B3-induced acute myocarditis. 61
32771878 2020
40
Use of the new Lake Louise Criteria improves CMR detection of atypical forms of acute myocarditis. 61
33190198 2020
41
Acute myocarditis associated with COVID-19 infection. 61
32507570 2020
42
Multisystem inflammatory syndrome with refractory cardiogenic shock due to acute myocarditis and mononeuritis multiplex after SARS-CoV-2 infection in an adult. 61
33181855 2020
43
A rare case of myocardial calcification secondary to acute myocarditis due to an Escherichia coli infection. 61
33311807 2020
44
Management of Acute Myocarditis and Chronic Inflammatory Cardiomyopathy: An Expert Consensus Document. 61
33176455 2020
45
A Novel DSP Truncating Variant in a Family with Episodic Myocardial Injury in the Course of Arrhythmogenic Cardiomyopathy-A Possible Role of a Low Penetrance NLRP3 Variant. 61
33207704 2020
46
Wilms Tumor with dilated hypertensive cardiomyopathy, acute myocarditis, pulmonary edema, and heart failure. 61
33102089 2020
47
Role of electrocardiograms in assessment of severity and analysis of the characteristics of ST elevation in acute myocarditis: A two-centre study. 61
32934685 2020
48
COVID-19-Associated Suspected Myocarditis as the Etiology for Recurrent and Protracted Fever in an Otherwise Healthy Adult. 61
33546881 2020
49
Acute Myocarditis Related to COVID-19: Comparison to SARS and MERS. 61
33235977 2020
50
Quantifying and reporting cardiac findings in imaging of COVID-19 patients. 61
33169595 2020

Variations for Acute Myocarditis

Expression for Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for Acute Myocarditis

Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 TXN TNF TLR3 STAT1 IL10 FASLG
2
Show member pathways
13.79 TNF TNC STAT1 IL10 FASLG FAS
3
Show member pathways
13.31 TNF TLR3 STAT1 IL10 FASLG FAS
4
Show member pathways
13.3 TNF STAT1 IL10 FASLG CD86 CD70
5
Show member pathways
13.27 TNF IL10 FASLG FAS CD70 CD40
6
Show member pathways
12.95 TNF TNC TLR3 STAT1 FASLG FAS
7
Show member pathways
12.84 TNF TLR3 STAT1 FASLG FAS CD86
8 12.77 TNF TLR3 STAT1 FASLG FAS
9
Show member pathways
12.75 TNF TLR3 STAT1 FASLG FAS CD40
10
Show member pathways
12.6 TNF IL10 CD86 CD40 CD4
11
Show member pathways
12.55 TNF STAT1 FASLG FAS CD70 CD40
12
Show member pathways
12.54 TNF STAT1 IL10 FAS CD4
13
Show member pathways
12.53 TNF STAT1 IL10 CD86 CD4
14
Show member pathways
12.5 TNF STAT1 IL10 FASLG FAS CD86
15
Show member pathways
12.5 TNF TLR3 STAT1 IL10 FASLG FAS
16
Show member pathways
12.49 TNF TLR3 FASLG FAS CD70 CD40
17 12.38 TXN TNF TLR3 STAT1 IL10 FASLG
18
Show member pathways
12.25 TXN TNF STAT1 FASLG FAS
19
Show member pathways
12.23 TNF STAT1 IL10 CD40
20
Show member pathways
12.22 TNNT2 TNNI3 TNF ACE
21 12.21 TXN TNF FASLG FAS
22
Show member pathways
12.14 TNF STAT1 FASLG FAS
23
Show member pathways
11.96 TNF TLR3 STAT1 H2AC18 FASLG FAS
24 11.94 TNF IL10 CD86 CD4
25 11.92 TNF STAT1 IL10 FASLG
26
Show member pathways
11.8 TLR3 STAT1 CD86 CD4
27 11.75 TNF IL10 CD4
28 11.71 TNF IL10 CD4
29
Show member pathways
11.68 TNF FASLG FAS CD70 CD40
30 11.66 TNF IL10 CD40
31 11.52 TNF FASLG FAS
32 11.5 TNF IL10 CD40
33 11.49 TNF IL10 CD86
34 11.45 IL10 CD86 CD4
35 11.42 TNF FASLG FAS
36 11.33 TNF IL10 FASLG FAS
37
Show member pathways
11.29 TNF IL10 FASLG FAS
38 11.19 TNF IL10 CD4
39
Show member pathways
10.98 TNF TLR3 STAT1 IL10 CD86 CD4

GO Terms for Acute Myocarditis

Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.06 TXN MB H2AC18 FASLG FAS CD86
2 extracellular region GO:0005576 10.02 TXN TNF TNC NPPB IL10 FASLG
3 extracellular space GO:0005615 9.85 TNF TNC TLR3 NPPB IL10 FASLG
4 membrane raft GO:0045121 9.76 TNF FASLG FAS CD4
5 cell surface GO:0009986 9.5 TNF TLR3 FASLG FAS CD86 CD40
6 troponin complex GO:0005861 9.43 TNNT2 TNNI3
7 cardiac myofibril GO:0097512 9.37 TNNT2 TNNI3
8 cardiac Troponin complex GO:1990584 9.26 TNNT2 TNNI3
9 external side of plasma membrane GO:0009897 9.17 TNF FASLG FAS CD86 CD40 CD4

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.86 TNF TLR3 IL10 FASLG FAS CD86
2 positive regulation of protein phosphorylation GO:0001934 9.83 TNF FAS CD40 CD4
3 cytokine-mediated signaling pathway GO:0019221 9.8 TNF STAT1 IL10 FASLG CD86 CD4
4 cellular response to lipopolysaccharide GO:0071222 9.78 TNF IL10 CD86 CD40
5 cellular response to mechanical stimulus GO:0071260 9.77 TLR3 FAS CD40
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.77 TNF TLR3 FASLG CD40 CD4
7 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.73 TNF TLR3 CD86
8 positive regulation of T cell proliferation GO:0042102 9.71 CD86 CD70 CD4
9 apoptotic signaling pathway GO:0097190 9.71 TNF TLR3 FASLG FAS
10 positive regulation of cytokine production GO:0001819 9.69 TNF TLR3 IL10
11 B cell proliferation GO:0042100 9.63 IL10 CD70 CD40
12 tumor necrosis factor-mediated signaling pathway GO:0033209 9.63 TNF STAT1 FASLG FAS CD70 CD40
13 CD40 signaling pathway GO:0023035 9.58 CD86 CD40
14 negative regulation of lipid storage GO:0010888 9.58 TNF CRP
15 regulation of immunoglobulin production GO:0002637 9.57 TNF CD40
16 endothelial cell apoptotic process GO:0072577 9.55 TNF IL10
17 negative regulation of cytokine production involved in immune response GO:0002719 9.49 TNF IL10
18 positive regulation of peptidyl-cysteine S-nitrosylation GO:2000170 9.43 TXN ACE
19 extrinsic apoptotic signaling pathway GO:0097191 9.35 TNF TLR3 FASLG FAS CD70
20 necroptotic signaling pathway GO:0097527 8.92 TNF TLR3 FASLG FAS

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 TNF IL10 FASLG CD70
2 signaling receptor activity GO:0038023 9.35 TLR3 FAS CD86 CD40 CD4
3 troponin C binding GO:0030172 9.16 TNNT2 TNNI3
4 tumor necrosis factor receptor binding GO:0005164 8.92 TNF STAT1 FASLG CD70

Sources for Acute Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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