ANE
MCID: ACT064
MIFTS: 33

Acute Necrotizing Encephalitis (ANE)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Necrotizing Encephalitis

MalaCards integrated aliases for Acute Necrotizing Encephalitis:

Name: Acute Necrotizing Encephalitis 12 52 15
Acute Necrotizing Encephalopathy 52
Encephalitis, Acute Necrotizing 71
Ane 52

Classifications:



External Ids:

Disease Ontology 12 DOID:5222
MeSH 43 D004684
NCIt 49 C35383
SNOMED-CT 67 111897007
UMLS 71 C0338418

Summaries for Acute Necrotizing Encephalitis

NIH Rare Diseases : 52 Acute necrotizing encephalopathy (ANE) is a rare disease characterized by brain damage (encephalopathy) that usually follows an acute febrile disease, mostly viral infections. . Most of the reported cases are from previously healthy Japanese and Taiwanese children, but it is now known that the disease may affect anybody in the world. The symptoms of the viral infection (fever, respiratory infection, and gastroenteritis , among others) are followed by seizures , disturbance of consciousness that may rapidly progress to a coma, liver problems, and neurological deficits. The disease is caused by both environmental factors and genetic factors. Usually, ANE develops secondary to viral infections, among which the influenza A , influenza B , and the human herpes virus 6 , are the most common. ANE can be familial or sporadic, but both forms are very similar to each other. Most familial cases are caused by mutations in the RANBP2 gene , and are known as " infection-induced acute encephalopathy 3 (IIAE3) ". Although the clinical course and the prognosis of ANE are diverse, the characteristic that is specific to the disease is the "multifocal symmetric brain lesions affecting the thalami, brain stem, cerebral white matter, and cerebellum" which can be seen on computed tomography (CT) or magnetic resonance imaging (MRI) exams. A picture of the brain may help you better visualize the areas of the brain affected. The best treatment of ANE is still under investigation but may include corticosteroids and anticytokine therapies , including TNF? antagonists .

MalaCards based summary : Acute Necrotizing Encephalitis, also known as acute necrotizing encephalopathy, is related to folliculitis and familial acute necrotizing encephalopathy. An important gene associated with Acute Necrotizing Encephalitis is RANBP2 (RAN Binding Protein 2), and among its related pathways/superpathways are Signaling events mediated by HDAC Class I and Proteolysis Putative SUMO-1 pathway. Affiliated tissues include brain, cerebellum and liver.

Related Diseases for Acute Necrotizing Encephalitis

Diseases related to Acute Necrotizing Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 13217)
# Related Disease Score Top Affiliating Genes
1 folliculitis 29.1 IL10RB CD160
2 familial acute necrotizing encephalopathy 12.6
3 hair-an syndrome 12.4
4 rare hemorrhagic disorder due to an acquired platelet anomaly 12.3
5 hemophagocytic syndrome associated with an infection 12.2
6 rare hemorrhagic disorder due to an acquired coagulation factor defect 12.2
7 sickle cell disease associated with an other hemoglobin anomaly 12.2
8 silver-russell syndrome due to an imprinting defect of 11p15 12.2
9 hemolytic anemia due to an erythrocyte nucleotide metabolism disorder 12.2
10 sucking/swallowing disorder associated with an identified syndrome 12.1
11 rare thrombotic disorder due to an acquired platelet anomaly 12.1
12 rare thrombotic disorder due to an acquired coagulation factors defect 12.1
13 systemic inflammatory disease associated with an acquired peripheral neuropathy 12.1
14 hematological disease associated with an acquired peripheral neuropathy 12.1
15 solid tumor associated with an acquired peripheral neuropathy 12.1
16 rare female infertility due to an implantation defect 12.1
17 female infertility due to an implantation defect of genetic origin 12.1
18 rare female infertility due to an anomaly of ovarian function of genetic origin 12.1
19 rare female infertility due to an anomaly of ovarian function 12.1
20 rare female infertility due to an adrenal disorder 12.1
21 rare constitutional hemolytic anemia due to an enzyme disorder 12.1
22 congenital intestinal disease due to an enzymatic defect 12.1
23 alopecia, neurologic defects, and endocrinopathy syndrome 12.0
24 encephalopathy, acute, infection-induced 4 11.9
25 schizophrenia 11.8
26 aniridia 1 11.8
27 acanthosis nigricans 11.8
28 anorexia nervosa 11.7
29 schizophrenia 1 11.6
30 schizophrenia 3 11.6
31 schizophrenia 7 11.6
32 polydactyly, preaxial iii 11.6
33 schizophrenia 18 11.6
34 blood group--ahonen 11.6
35 acute necrotizing encephalopathy type 1 11.5
36 schizophrenia 8 11.4
37 bile duct cystadenocarcinoma 11.4
38 schizophrenia 5 11.4
39 schizophrenia 9 11.4
40 systemic mastocytosis with associated hematologic neoplasm 11.4
41 schizophrenia 15 11.2
42 schizophrenia 19 11.2
43 aneurysm 11.2
44 diarrhea 11.1
45 migraine with or without aura 1 11.1
46 ataxia neuropathy spectrum 11.1
47 immunodeficiency due to a classical component pathway complement deficiency 11.1
48 aortic aneurysm 11.1
49 atrial fibrillation 11.1
50 down syndrome 11.1

Graphical network of the top 20 diseases related to Acute Necrotizing Encephalitis:



Diseases related to Acute Necrotizing Encephalitis

Symptoms & Phenotypes for Acute Necrotizing Encephalitis

Drugs & Therapeutics for Acute Necrotizing Encephalitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The International Database for Leigh Syndrome Recruiting NCT03137355

Search NIH Clinical Center for Acute Necrotizing Encephalitis

Genetic Tests for Acute Necrotizing Encephalitis

Anatomical Context for Acute Necrotizing Encephalitis

MalaCards organs/tissues related to Acute Necrotizing Encephalitis:

40
Brain, Cerebellum, Liver, Temporal Lobe, Pituitary

Publications for Acute Necrotizing Encephalitis

Articles related to Acute Necrotizing Encephalitis:

(show top 50) (show all 73)
# Title Authors PMID Year
1
Miller-Fisher syndrome after SARS-CoV-2 infection. 61
32503084 2020
2
Clinical Features and Risk Factors for Mortality in Children With Acute Encephalitis Who Present to the Emergency Department. 61
32507002 2020
3
Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms. 61
32458193 2020
4
Acute Necrotizing Encephalitis in Viral Respiratory Tract Infection: An Autopsy Case Report. 61
32542125 2020
5
Neurologic Manifestations of Severe Respiratory Viral Contagions. 61
32426749 2020
6
Acute Necrotizing Encephalopathy Associated with Influenza A. 61
32101112 2020
7
[Influenza-associated acute necrotizing encephalitis in an adult]. 61
32490626 2020
8
Acute necrotizing encephalopathy in an adult as a complication of H1N1 infection. 61
31938561 2019
9
[Encephalitis caused by type B influenza virus in an adult. Report of one case]. 61
31859991 2019
10
Varying Patterns of CNS Imaging in Influenza A Encephalopathy in Childhood. 61
30610262 2019
11
[Influenza - associated acute necrotizing encephalitis in adults]. 61
31994522 2019
12
Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders. 61
30863282 2019
13
Acute necrotizing encephalitis associated with cardiovascular manifestations. 61
28681764 2017
14
Successful Treatment of Influenza-Associated Acute Necrotizing Encephalitis in an Adult Using High-Dose Oseltamivir and Methylprednisolone: Case Report and Literature Review. 61
28852683 2017
15
The etiology of ring lesions on diffusion-weighted imaging. 61
24976194 2014
16
[MRI and CT in the diagnosis of epilepsy]. 61
24912281 2014
17
Involvement of type I immune responses in swine-origin H1N1 influenza virus infection. 61
21571020 2011
18
Cerebral folate deficiency syndromes in childhood: clinical, analytical, and etiologic aspects. 61
21555636 2011
19
[Acute infantile bilateral thalamic necrosis]. 61
12589597 2003
20
Unusual encephalopathy after acute chest syndrome in sickle cell disease: acute necrotizing encephalitis. 61
12368703 2002
21
[Value of interferon alpha determination in the diagnosis of meningoencephalitis presumed to be of viral origin]. 61
1329171 1992
22
[Value of sphenoidal electrodes in the EEG diagnosis of herpes encephalitis]. 61
1965454 1990
23
[Periodic discharges and diagnosis of central nervous system diseases]. 61
2654609 1989
24
A clinico-pathological study of herpes simplex encephalitis. 61
3200368 1988
25
A retrospective analysis of forty-six cases of herpes simplex encephalitis seen in Glasgow between 1962 and 1985. 61
3252305 1988
26
Comparison of in situ DNA hybridization (ISH) and immunocytochemistry for diagnosis of herpes simplex virus (HSV) encephalitis in tissue. 61
2849835 1988
27
Central nervous system lesions in suckling mice and rats inoculated intranasally with sialodacryoadenitis virus. 61
3004003 1986
28
[A case of acute necrotizing encephalitis caused by herpes simplex virus--a clinico-morphological analysis]. 61
4094645 1985
29
Herpes simplex encephalitis. 61
6089538 1984
30
[Herpes simplex type acute necrotizing encephalitis]. 61
7176881 1982
31
[Herpes simplex encephalitis in neuro-surgery. Electro-encephalographic contribution to early diagnosis (author's transl)]. 61
6283648 1982
32
[Meningoencephalitis in a case of Behçet's disease. Electroencephalographic findings (author's transl)]. 61
7242172 1981
33
Non-productive paramyxovirus infection: Nariva virus infection in hamsters. 61
518307 1979
34
The late effects of necrotizing encephalitis of the temporal lobes and limbic areas: a clinico-pathological study of 10 cases. 61
635068 1978
35
Acute necrotizing encephalitis. 61
604290 1977
36
[Herpes simplex encephalitis. A case report with support of the diagnosis by means of brain biopsy]. 61
194307 1977
37
[Anatomoclinical study of 29 cases of acute necrotizing encephalitis. Demonstration of herpes virus in 24 cases]. 61
1023785 1976
38
[Herpes simplex encephalitis. Acute necrotizing encephalitis and benign herpes simplex encephalitis]. 61
4363988 1974
39
[Letter: Acute necrotizing encephalitis. Serological diagnosis in herpesvirus infection]. 61
4356024 1973
40
Acute necrotizing encephalitis complicating bifrontal craniotomy and pituitary curettage. Report of two cases. 61
4335254 1972
41
Acute necrotizing encephalitis in a patient with Hodgkin's disease. A case report. 61
4334821 1971
42
Cerebrospinal fluid in acute necrotizing encephalitis. Hypochlorrhachia as a diagnostic aid. 61
5112210 1971
43
[Acute necrotizing encephalitis caused by herpes simplex virus]. 61
5126701 1971
44
Acute necrotizing encephalitis caused by herpes simplex virus. Two cases treated with 5-iodo-2-deoxyuridine. 61
5110953 1971
45
The protein composition of the cerebrospinal fluid in acute necrotizing encephalitis. An agar gel electrophoretic and immunoelectrophoretic study. 61
4097238 1970
46
The EEG of acute necrotizing encephalitis. 61
4188490 1970
47
[The vascular factor in the pathogenesis of acute necrotizing encephalitis]. 61
5801399 1969
48
Clinical problems of acute necrotizing encephalitis. 61
4313666 1969
49
Periventricular astrocytosis and acute necrotizing encephalitis. 61
5708550 1968
50
Acute necrotizing encephalitis. Report of a case associated with polycythemia vera. 61
5640195 1968

Variations for Acute Necrotizing Encephalitis

Expression for Acute Necrotizing Encephalitis

Search GEO for disease gene expression data for Acute Necrotizing Encephalitis.

Pathways for Acute Necrotizing Encephalitis

Pathways related to Acute Necrotizing Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.08 SUMO1 RANBP2
2
Show member pathways
10.89 SUMO1 RANBP2
3 10.49 SUMO1 RANBP2
4 9.66 SUMO1 RANBP2

GO Terms for Acute Necrotizing Encephalitis

Cellular components related to Acute Necrotizing Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear pore GO:0005643 8.96 SUMO1 RANBP2
2 anchored component of plasma membrane GO:0046658 8.62 FOLR1 CD160

Biological processes related to Acute Necrotizing Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein sumoylation GO:0016925 8.62 SUMO1 RANBP2

Molecular functions related to Acute Necrotizing Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 8.8 NECTIN1 IL10RB FOLR1

Sources for Acute Necrotizing Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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