MCID: ACT064
MIFTS: 30

Acute Necrotizing Encephalitis

Categories: Neuronal diseases

Aliases & Classifications for Acute Necrotizing Encephalitis

MalaCards integrated aliases for Acute Necrotizing Encephalitis:

Name: Acute Necrotizing Encephalitis 12 15
Encephalitis, Acute Necrotizing 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5222
MeSH 45 D004684
NCIt 51 C35383
UMLS 74 C0338418

Summaries for Acute Necrotizing Encephalitis

MalaCards based summary : Acute Necrotizing Encephalitis, also known as encephalitis, acute necrotizing, is related to acute necrotizing encephalopathy and acute necrotizing encephalopathy type 1. An important gene associated with Acute Necrotizing Encephalitis is FOLR1 (Folate Receptor Alpha), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. Affiliated tissues include t cells, temporal lobe and pituitary, and related phenotypes are cardiovascular system and cellular

Related Diseases for Acute Necrotizing Encephalitis

Diseases related to Acute Necrotizing Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 acute necrotizing encephalopathy 11.4
2 acute necrotizing encephalopathy type 1 11.4
3 encephalitis 10.6
4 erythema multiforme 10.1 GZMB IFNG
5 panniculitis 10.1 GZMB IFNG
6 rasmussen encephalitis 10.0 GZMB IFNG
7 acute graft versus host disease 10.0 GZMB IFNG
8 bronchiolitis obliterans 10.0 GZMB IFNG
9 alopecia areata 10.0 GZMB IFNG
10 polyradiculoneuropathy 10.0 IFNG PRF1
11 graft-versus-host disease 10.0 GZMB IFNG
12 lichen planus 10.0 GZMB IFNG
13 erythema elevatum diutinum 9.9 FOXP3 TBX21
14 cutaneous t cell lymphoma 9.9 GZMB IFNG
15 hypersplenism 9.9 FOXP3 IFNG
16 lichen disease 9.9 FOXP3 IFNG
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9 FOXP3 IFNG
18 lymphopenia 9.9 FOXP3 IFNG
19 autoimmune disease of endocrine system 9.9 FOXP3 IFNG
20 autoimmune disease of gastrointestinal tract 9.9 FOXP3 IFNG
21 polycythemia vera 9.9
22 acute chest syndrome 9.9
23 polycythemia 9.9
24 influenza 9.9
25 herpes simplex 9.9
26 sickle cell disease 9.9
27 encephalopathy 9.9
28 tropical spastic paraparesis 9.9 FOXP3 IFNG
29 autoimmune disease of central nervous system 9.8 FOXP3 IFNG
30 food allergy 9.8 FOXP3 IFNG
31 upper respiratory tract disease 9.8 FOXP3 IFNG
32 cutaneous leishmaniasis 9.8 FOXP3 IFNG
33 visceral leishmaniasis 9.8 FOXP3 IFNG
34 relapsing-remitting multiple sclerosis 9.8 FOXP3 IFNG
35 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.8 FOXP3 IFNG
36 omenn syndrome 9.7 FOXP3 IFNG
37 hemophagocytic lymphohistiocytosis 9.7 GZMB IFNG PRF1
38 immune system disease 9.7 FOXP3 IFNG
39 gastrointestinal system disease 9.7 FOXP3 IFNG
40 pancreas adenocarcinoma 9.6 FOXP3 IFNG
41 multiple sclerosis 9.5 FOXP3 IFNG PRF1
42 dermatitis, atopic 9.5 FOXP3 IFNG
43 aplastic anemia 9.3 FOXP3 IFNG PRF1 TBX21

Graphical network of the top 20 diseases related to Acute Necrotizing Encephalitis:



Diseases related to Acute Necrotizing Encephalitis

Symptoms & Phenotypes for Acute Necrotizing Encephalitis

MGI Mouse Phenotypes related to Acute Necrotizing Encephalitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.72 FOLR1 FOXP3 IFNG PRF1 TBX21
2 cellular MP:0005384 9.65 FOLR1 FOXP3 IFNG PRF1 TBX21
3 digestive/alimentary MP:0005381 9.46 FOLR1 FOXP3 IFNG TBX21
4 endocrine/exocrine gland MP:0005379 9.35 FOLR1 FOXP3 IFNG PRF1 TBX21
5 neoplasm MP:0002006 8.92 FOLR1 IFNG PRF1 TBX21

Drugs & Therapeutics for Acute Necrotizing Encephalitis

Search Clinical Trials , NIH Clinical Center for Acute Necrotizing Encephalitis

Genetic Tests for Acute Necrotizing Encephalitis

Anatomical Context for Acute Necrotizing Encephalitis

MalaCards organs/tissues related to Acute Necrotizing Encephalitis:

42
T Cells, Temporal Lobe, Pituitary, Pancreas

Publications for Acute Necrotizing Encephalitis

Articles related to Acute Necrotizing Encephalitis:

(show all 24)
# Title Authors Year
1
Acute necrotizing encephalitis associated with cardiovascular manifestations. ( 28681764 )
2017
2
Successful Treatment of Influenza-Associated Acute Necrotizing Encephalitis in an Adult Using High-Dose Oseltamivir and Methylprednisolone: Case Report and Literature Review. ( 28852683 )
2017
3
Unusual encephalopathy after acute chest syndrome in sickle cell disease: acute necrotizing encephalitis. ( 12368703 )
2002
4
Acute necrotizing encephalitis. ( 604290 )
1977
5
Acute necrotizing encephalitis complicating bifrontal craniotomy and pituitary curettage. Report of two cases. ( 4335254 )
1972
6
Acute necrotizing encephalitis in a patient with Hodgkin's disease. A case report. ( 4334821 )
1971
7
Acute necrotizing encephalitis caused by herpes simplex virus. Two cases treated with 5-iodo-2-deoxyuridine. ( 5110953 )
1971
8
Cerebrospinal fluid in acute necrotizing encephalitis. Hypochlorrhachia as a diagnostic aid. ( 5112210 )
1971
9
The protein composition of the cerebrospinal fluid in acute necrotizing encephalitis. An agar gel electrophoretic and immunoelectrophoretic study. ( 4097238 )
1970
10
The EEG of acute necrotizing encephalitis. ( 4188490 )
1970
11
Clinical problems of acute necrotizing encephalitis. ( 4313666 )
1969
12
Acute necrotizing encephalitis. ( 4295233 )
1968
13
Acute necrotizing encephalitis. Report of a case associated with polycythemia vera. ( 5640195 )
1968
14
Periventricular astrocytosis and acute necrotizing encephalitis. ( 5708550 )
1968
15
Acute necrotizing encephalitis: a problem in diagnosis. ( 4291841 )
1967
16
Acute necrotizing encephalitis. ( 4292085 )
1967
17
Acute necrotizing encephalitis. ( 20329030 )
1967
18
Acute necrotizing encephalitis: observations of herpes-like particles by electron microscopy. ( 4295102 )
1966
19
Atypic acute necrotizing encephalitis. ( 6004659 )
1966
20
An acute necrotizing encephalitis with atypical features. ( 6004660 )
1966
21
RADIOLOGIC FINDINGS IN ACUTE NECROTIZING ENCEPHALITIS. ( 14323906 )
1965
22
ACUTE NECROTIZING ENCEPHALITIS. ( 14158092 )
1964
23
Acute necrotizing encephalitis. A diagnostic problem in temporal lobe disease: report of three cases. ( 13867295 )
1962
24
Acute necrotizing encephalitis. A diagnostic problem in unilateral temporal lobe disease. ( 13867294 )
1961

Variations for Acute Necrotizing Encephalitis

Expression for Acute Necrotizing Encephalitis

Search GEO for disease gene expression data for Acute Necrotizing Encephalitis.

Pathways for Acute Necrotizing Encephalitis

Pathways related to Acute Necrotizing Encephalitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 FOXP3 GZMB IFNG PRF1
2
Show member pathways
12.21 FOXP3 IFNG TBX21
3
Show member pathways
12.13 GZMB IFNG PRF1
4 11.97 FOXP3 GZMB IFNG TBX21
5
Show member pathways
11.67 IFNG TBX21
6
Show member pathways
11.6 GZMB IFNG TBX21
7 11.46 IFNG TBX21
8 11.4 GZMB IFNG TBX21
9
Show member pathways
11.36 FOXP3 PRF1
10
Show member pathways
11.31 FOXP3 IFNG TBX21
11
Show member pathways
11.21 GZMB PRF1
12 11.17 FOXP3 IFNG
13 10.96 IFNG TBX21
14
Show member pathways
10.92 GZMB IFNG PRF1
15
Show member pathways
10.9 IFNG PRF1
16 10.25 IFNG PRF1 TBX21

GO Terms for Acute Necrotizing Encephalitis

Biological processes related to Acute Necrotizing Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.65 GZMB IFNG PRF1
2 negative regulation of transcription, DNA-templated GO:0045892 9.63 FOXP3 IFNG TBX21
3 positive regulation of gene expression GO:0010628 9.61 FOXP3 IFNG TBX21
4 cytolysis GO:0019835 9.4 GZMB PRF1
5 regulation of regulatory T cell differentiation GO:0045589 9.37 FOXP3 IFNG
6 response to virus GO:0009615 9.33 FOXP3 IFNG TBX21
7 negative regulation of interleukin-2 production GO:0032703 9.32 FOXP3 TBX21
8 negative regulation of interleukin-17 production GO:0032700 9.26 FOXP3 IFNG
9 negative regulation of T-helper 17 cell differentiation GO:2000320 8.96 FOXP3 TBX21
10 positive regulation of killing of cells of other organism GO:0051712 8.62 IFNG PRF1

Sources for Acute Necrotizing Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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