MCID: ACT064
MIFTS: 28

Acute Necrotizing Encephalitis

Categories: Neuronal diseases

Aliases & Classifications for Acute Necrotizing Encephalitis

MalaCards integrated aliases for Acute Necrotizing Encephalitis:

Name: Acute Necrotizing Encephalitis 12 15
Encephalitis, Acute Necrotizing 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5222
MeSH 44 D004684
NCIt 50 C35383
SNOMED-CT 68 111897007
UMLS 73 C0338418

Summaries for Acute Necrotizing Encephalitis

MalaCards based summary : Acute Necrotizing Encephalitis, also known as encephalitis, acute necrotizing, is related to acute necrotizing encephalopathy and acute necrotizing encephalopathy type 1. An important gene associated with Acute Necrotizing Encephalitis is FOLR1 (Folate Receptor 1), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. Affiliated tissues include temporal lobe and pituitary, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Acute Necrotizing Encephalitis

Diseases related to Acute Necrotizing Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 acute necrotizing encephalopathy 11.2
2 acute necrotizing encephalopathy type 1 11.2
3 encephalitis 10.4
4 erythema multiforme 10.0 GZMB IFNG
5 panniculitis 10.0 GZMB IFNG
6 rasmussen encephalitis 10.0 GZMB IFNG
7 acute graft versus host disease 10.0 GZMB IFNG
8 bronchiolitis obliterans 10.0 GZMB IFNG
9 alopecia areata 9.9 GZMB IFNG
10 graft-versus-host disease 9.9 GZMB IFNG
11 lichen planus 9.9 GZMB IFNG
12 cutaneous t cell lymphoma 9.9 GZMB IFNG
13 hypersplenism 9.8 FOXP3 IFNG
14 lichen disease 9.8 FOXP3 IFNG
15 autoimmune disease of endocrine system 9.8 FOXP3 IFNG
16 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8 FOXP3 IFNG
17 tropical spastic paraparesis 9.8 FOXP3 IFNG
18 food allergy 9.7 FOXP3 IFNG
19 polycythemia vera 9.7
20 acute chest syndrome 9.7
21 polycythemia 9.7
22 influenza 9.7
23 herpes simplex 9.7
24 sickle cell disease 9.7
25 encephalopathy 9.7
26 intestinal disease 9.7 FOXP3 IFNG
27 hypersensitivity reaction disease 9.7 FOXP3 IFNG
28 lymphopenia 9.7 FOXP3 IFNG
29 relapsing-remitting multiple sclerosis 9.7 FOXP3 IFNG
30 immune system disease 9.6 FOXP3 IFNG
31 omenn syndrome 9.6 FOXP3 IFNG
32 hemophagocytic lymphohistiocytosis 9.6 GZMB IFNG
33 visceral leishmaniasis 9.6 FOXP3 IFNG
34 pancreas adenocarcinoma 9.5 FOXP3 IFNG
35 colitis 9.2 FOXP3 IFNG
36 aplastic anemia 9.2 FOXP3 IFNG TBX21
37 cutaneous leishmaniasis 9.1 FOXP3 GZMB IFNG
38 celiac disease 1 9.1 FOXP3 GZMB IFNG
39 common variable immunodeficiency 9.0 FOXP3 IFNG
40 inflammatory bowel disease 8.9 FOXP3 IFNG TBX21
41 diabetes mellitus 8.7 FOXP3 GZMB IFNG

Graphical network of the top 20 diseases related to Acute Necrotizing Encephalitis:



Diseases related to Acute Necrotizing Encephalitis

Symptoms & Phenotypes for Acute Necrotizing Encephalitis

MGI Mouse Phenotypes related to Acute Necrotizing Encephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 FOLR1 FOXP3 IFNG TBX21
2 endocrine/exocrine gland MP:0005379 8.92 FOLR1 FOXP3 IFNG TBX21

Drugs & Therapeutics for Acute Necrotizing Encephalitis

Search Clinical Trials , NIH Clinical Center for Acute Necrotizing Encephalitis

Genetic Tests for Acute Necrotizing Encephalitis

Anatomical Context for Acute Necrotizing Encephalitis

MalaCards organs/tissues related to Acute Necrotizing Encephalitis:

41
Temporal Lobe, Pituitary

Publications for Acute Necrotizing Encephalitis

Articles related to Acute Necrotizing Encephalitis:

(show all 24)
# Title Authors Year
1
Successful Treatment of Influenza-Associated Acute Necrotizing Encephalitis in an Adult Using High-Dose Oseltamivir and Methylprednisolone: Case Report and Literature Review. ( 28852683 )
2017
2
Acute necrotizing encephalitis associated with cardiovascular manifestations. ( 28681764 )
2017
3
Unusual encephalopathy after acute chest syndrome in sickle cell disease: acute necrotizing encephalitis. ( 12368703 )
2002
4
Acute necrotizing encephalitis. ( 604290 )
1977
5
Acute necrotizing encephalitis complicating bifrontal craniotomy and pituitary curettage. Report of two cases. ( 4335254 )
1972
6
Cerebrospinal fluid in acute necrotizing encephalitis. Hypochlorrhachia as a diagnostic aid. ( 5112210 )
1971
7
Acute necrotizing encephalitis caused by herpes simplex virus. Two cases treated with 5-iodo-2-deoxyuridine. ( 5110953 )
1971
8
Acute necrotizing encephalitis in a patient with Hodgkin's disease. A case report. ( 4334821 )
1971
9
The protein composition of the cerebrospinal fluid in acute necrotizing encephalitis. An agar gel electrophoretic and immunoelectrophoretic study. ( 4097238 )
1970
10
The EEG of acute necrotizing encephalitis. ( 4188490 )
1970
11
Clinical problems of acute necrotizing encephalitis. ( 4313666 )
1969
12
Periventricular astrocytosis and acute necrotizing encephalitis. ( 5708550 )
1968
13
Acute necrotizing encephalitis. Report of a case associated with polycythemia vera. ( 5640195 )
1968
14
Acute necrotizing encephalitis. ( 4295233 )
1968
15
Acute necrotizing encephalitis. ( 4292085 )
1967
16
Acute necrotizing encephalitis: a problem in diagnosis. ( 4291841 )
1967
17
Acute necrotizing encephalitis. ( 20329030 )
1967
18
Atypic acute necrotizing encephalitis. ( 6004659 )
1966
19
Acute necrotizing encephalitis: observations of herpes-like particles by electron microscopy. ( 4295102 )
1966
20
An acute necrotizing encephalitis with atypical features. ( 6004660 )
1966
21
RADIOLOGIC FINDINGS IN ACUTE NECROTIZING ENCEPHALITIS. ( 14323906 )
1965
22
ACUTE NECROTIZING ENCEPHALITIS. ( 14158092 )
1964
23
Acute necrotizing encephalitis. A diagnostic problem in temporal lobe disease: report of three cases. ( 13867295 )
1962
24
Acute necrotizing encephalitis. A diagnostic problem in unilateral temporal lobe disease. ( 13867294 )
1961

Variations for Acute Necrotizing Encephalitis

Expression for Acute Necrotizing Encephalitis

Search GEO for disease gene expression data for Acute Necrotizing Encephalitis.

Pathways for Acute Necrotizing Encephalitis

GO Terms for Acute Necrotizing Encephalitis

Biological processes related to Acute Necrotizing Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.58 FOXP3 IFNG TBX21
2 negative regulation of transcription, DNA-templated GO:0045892 9.54 FOXP3 IFNG TBX21
3 regulation of regulatory T cell differentiation GO:0045589 9.32 FOXP3 IFNG
4 negative regulation of interleukin-2 production GO:0032703 9.26 FOXP3 TBX21
5 negative regulation of interleukin-17 production GO:0032700 9.16 FOXP3 IFNG
6 response to virus GO:0009615 9.13 FOXP3 IFNG TBX21
7 negative regulation of T-helper 17 cell differentiation GO:2000320 8.62 FOXP3 TBX21

Sources for Acute Necrotizing Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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