ANE
MCID: ACT232
MIFTS: 33

Acute Necrotizing Encephalopathy (ANE)

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Necrotizing Encephalopathy

MalaCards integrated aliases for Acute Necrotizing Encephalopathy:

Name: Acute Necrotizing Encephalopathy 53 29 73
Encephalitis, Acute Necrotizing 73
Acute Necrotizing Encephalitis 53
Ane 53

Classifications:



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Summaries for Acute Necrotizing Encephalopathy

NIH Rare Diseases : 53 Acute necrotizing encephalopathy (ANE) is a rare disease characterized by brain damage (encephalopathy) that usually follows an acute febrile disease, mostly viral infections.. Most of the reported cases are from previously healthy Japanese and Taiwanese children, but it is now known that the disease may affect anybody in the world.  The symptoms of the viral infection (fever, respiratory infection, and gastroenteritis, among others) are followed by seizures, disturbance of consciousness that may rapidly progress to a coma, liver problems, and neurological deficits. The disease is caused by both environmental factors and genetic factors. Usually, ANE develops secondary to viral infections, among which the influenza A, influenza B, and the human herpes virus 6, are the most common. ANE can be familial or sporadic, but both forms are very similar to each other. Most familial cases are caused by mutations in the RANBP2 gene, and are known as �??infection-induced acute encephalopathy 3 (IIAE3)�?�.  Although the clinical course and the prognosis of ANE are diverse, the characteristic that is specific to the disease is the �??multifocal symmetric brain lesions affecting the thalami, brain stem, cerebral white matter, and cerebellum�?� which can be seen on computed tomography (CT) or magnetic resonance imaging (MRI) exams. A picture of the brain may help you better visualize the areas of the brain affected. The best treatment of ANE is still under investigation but may include corticosteroids and anticytokine therapies, including TNFα antagonists. 

MalaCards based summary : Acute Necrotizing Encephalopathy, also known as encephalitis, acute necrotizing, is related to acute necrotizing encephalopathy type 1 and acute necrotizing encephalitis. An important gene associated with Acute Necrotizing Encephalopathy is RANBP2 (RAN Binding Protein 2). Affiliated tissues include brain, liver and cerebellum.

Related Diseases for Acute Necrotizing Encephalopathy

Diseases in the Acute Necrotizing Encephalopathy family:

Acute Necrotizing Encephalopathy Type 1 Familial Acute Necrotizing Encephalopathy

Diseases related to Acute Necrotizing Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 10450)
# Related Disease Score Top Affiliating Genes
1 acute necrotizing encephalopathy type 1 12.7
2 acute necrotizing encephalitis 12.5
3 familial acute necrotizing encephalopathy 12.5
4 hair-an syndrome 12.3
5 hemophagocytic syndrome associated with an infection 12.1
6 systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease 12.1
7 sickle cell disease associated with an other hemoglobin anomaly 12.0
8 silver-russell syndrome due to an imprinting defect of 11p15 12.0
9 encephalopathy, acute, infection-induced 4 11.8
10 aniridia 1 11.6
11 acanthosis nigricans 11.6
12 alopecia, neurologic defects, and endocrinopathy syndrome 11.6
13 anorexia nervosa 11.6
14 schizophrenia 1 11.5
15 schizophrenia 11.5
16 polydactyly, preaxial iii 11.4
17 pheochromocytoma 11.3
18 schizophrenia 3 11.3
19 schizophrenia 7 11.3
20 schizophrenia 8 11.3
21 blood group--ahonen 11.3
22 schizophrenia 15 11.1
23 schizophrenia 18 11.1
24 schizophrenia 19 11.1
25 schizophrenia 5 10.9
26 schizophrenia 9 10.9
27 bile duct cystadenocarcinoma 10.9
28 morel's ear 10.9
29 ataxia neuropathy spectrum 10.9
30 immunodeficiency due to a classical component pathway complement deficiency 10.9
31 encephalopathy 10.9
32 leukemia 10.9
33 breast cancer 10.8
34 aortic aneurysm 10.8
35 meningitis 10.8
36 multiple sclerosis 10.8
37 rheumatoid arthritis 10.8
38 arthritis 10.8
39 asthma 10.8
40 atrial fibrillation 10.8
41 pneumonia 10.8
42 prostate cancer 10.8
43 myocardial infarction 10.8
44 ovarian cancer 10.8
45 anxiety 10.8
46 antiphospholipid syndrome 10.8
47 endocarditis 10.8
48 arteriovenous malformation 10.8
49 hepatitis 10.8
50 hepatitis c 10.8

Graphical network of the top 20 diseases related to Acute Necrotizing Encephalopathy:



Diseases related to Acute Necrotizing Encephalopathy

Symptoms & Phenotypes for Acute Necrotizing Encephalopathy

Drugs & Therapeutics for Acute Necrotizing Encephalopathy

Search Clinical Trials , NIH Clinical Center for Acute Necrotizing Encephalopathy

Genetic Tests for Acute Necrotizing Encephalopathy

Genetic tests related to Acute Necrotizing Encephalopathy:

# Genetic test Affiliating Genes
1 Acute Necrotizing Encephalopathy 29

Anatomical Context for Acute Necrotizing Encephalopathy

MalaCards organs/tissues related to Acute Necrotizing Encephalopathy:

41
Brain, Liver, Cerebellum, Lung, Kidney, Bone, Heart

Publications for Acute Necrotizing Encephalopathy

Articles related to Acute Necrotizing Encephalopathy:

(show top 50) (show all 121)
# Title Authors Year
1
RANBP2 Mutation in Clinically Undiagnosed Acute Necrotizing Encephalopathy. ( 29687329 )
2018
2
Evoked potential studies for predicting functional recovery in a case of acute necrotizing encephalopathy. ( 29744063 )
2018
3
Acute necrotizing encephalopathy in an adult with influenza A infection. ( 29720877 )
2018
4
Influenza-Associated Acute Necrotizing Encephalopathy in Siblings. ( 29741717 )
2018
5
Teaching NeuroImages: Acute necrotizing encephalopathy of childhood: Neuroimaging findings. ( 29311376 )
2018
6
Teaching NeuroImages: Radiographic evolution in an adult case of acute necrotizing encephalopathy. ( 30061348 )
2018
7
Steroids for familial acute necrotizing encephalopathy: A future investment? ( 30241006 )
2018
8
Acute necrotizing encephalopathy of childhood associated with human herpes virus 6 in Croatia. ( 30374582 )
2018
9
Acute necrotizing encephalopathy and a carnitine palmitoyltransferase 2 variant in an adult. ( 30470651 )
2018
10
Acute necrotizing encephalopathy causing human bocavirus. ( 28059631 )
2017
11
Familial acute necrotizing encephalopathy with RANBP2 mutation: The first report in Northeast Asia. ( 28336122 )
2017
12
Deep cerebral venous thrombosis mimicking influenza-associated acute necrotizing encephalopathy: a case report. ( 28950885 )
2017
13
Acute Necrotizing Encephalopathy of Childhood (ANEC): A Case Report. ( 28277560 )
2017
14
Acute Necrotizing Encephalopathy of Childhood Secondary to Dengue Infection: A Case Report from Pakistan. ( 28904577 )
2017
15
Brain damage resembling acute necrotizing encephalopathy as a specific manifestation of haemophagocytic lymphohistiocytosis - induced by hypersensitivity. ( 27576518 )
2016
16
Influenza B-associated acute necrotizing encephalopathy of childhood: a report from North America. ( 26627900 )
2016
17
Familial acute necrotizing encephalopathy without RANBP2 mutation: Poor outcome. ( 27882739 )
2016
18
Bilateral Thalamic Lesions in Acute Necrotizing Encephalopathy Due to H1N1 Infection. ( 27647154 )
2016
19
Specific HLA genotypes confer susceptibility to acute necrotizing encephalopathy. ( 27467284 )
2016
20
Influenza A (H1N1) Infection Associated Acute Necrotizing Encephalopathy in a Child With Periodic Lateralized Epileptiform Discharges. ( 27898637 )
2016
21
RANBP2 mutation in an Indian child with recurrent acute necrotizing encephalopathy. ( 27591117 )
2016
22
Influenza Virus-Associated Fatal Acute Necrotizing Encephalopathy: Role of Nonpermissive Viral Infection? ( 27812294 )
2016
23
Variable clinical course in acute necrotizing encephalopathy and identification of a novel RANBP2 mutation. ( 26923722 )
2016
24
Acute necrotizing encephalopathy: an underrecognized clinicoradiologic disorder. ( 25873770 )
2015
25
Acute necrotizing encephalopathy in an adult. ( 25973284 )
2015
26
Only a Touch of the Flu? The Simultaneous Manifestation of Acute Necrotizing Encephalopathy in Two Consanguineous Patients. ( 26110162 )
2015
27
RANBP2 mutation and acute necrotizing encephalopathy: 2 cases and a literature review of the expanding clinico-radiological phenotype. ( 25522933 )
2015
28
Fatal Acute Necrotizing Encephalopathy: Clinical Presentation and Imaging Findings. ( 25937389 )
2015
29
A severity score for acute necrotizing encephalopathy. ( 24931733 )
2015
30
H1N1 triggered recurrent acute necrotizing encephalopathy in a family with a T653I mutation in the RANBP2 gene. ( 25170550 )
2015
31
Hypoxic-ischemic encephalopathy mimicking acute necrotizing encephalopathy. ( 25447929 )
2015
32
An autopsy case of elderly-onset acute necrotizing encephalopathy secondary to influenza. ( 25982501 )
2015
33
Acute necrotizing encephalopathy secondary to sepsis. ( 25827707 )
2014
34
Clinical outcome of acute necrotizing encephalopathy in related to involving the brain stem of single institution in Korea. ( 25076971 )
2014
35
Familial acute necrotizing encephalopathy due to mutation in the RANBP2 gene. ( 25128471 )
2014
36
Correlation of serial MRI findings and clinical outcome in the first Croatian patient with acute necrotizing encephalopathy. ( 25165059 )
2014
37
Acute necrotizing encephalopathy secondary to sepsis. ( 25811213 )
2014
38
Acute necrotizing encephalopathy (ANE1): rare autosomal-dominant disorder presenting as acute transverse myelitis. ( 23329376 )
2013
39
Acute necrotizing encephalopathy associated with enterovirus infection. ( 22832063 )
2013
40
MRI gadolinium enhancement precedes neuroradiological findings in acute necrotizing encephalopathy. ( 23265619 )
2013
41
Novel Influenza A (H1N1)-Associated Acute Necrotizing Encephalopathy: A Case Report. ( 23705127 )
2013
42
A novel autoantibody against ephrin type B receptor 2 in acute necrotizing encephalopathy. ( 24139226 )
2013
43
Acute necrotizing encephalopathy of childhood; a case report. ( 24665298 )
2013
44
Immunomodulatory therapy in recurrent acute necrotizing encephalopathy ANE1: is it useful? ( 21945312 )
2012
45
Recurrent acute necrotizing encephalopathy in a Korean child: the first non-Caucasian case. ( 22566710 )
2012
46
A case of acute necrotizing encephalopathy associated with parainfluenza virus infection. ( 22574076 )
2012
47
Favorable outcomes in acute necrotizing encephalopathy in a child treated with hypothermia. ( 22633635 )
2012
48
Influenza A H1N1 Related Acute Necrotizing Encephalopathy: Radiological Findings in Adulthood. ( 24029031 )
2012
49
[Acute necrotizing encephalopathy]. ( 21400840 )
2011
50
Acute necrotizing encephalopathy of childhood: a fatal complication of swine flu. ( 21333249 )
2011

Variations for Acute Necrotizing Encephalopathy

Expression for Acute Necrotizing Encephalopathy

Search GEO for disease gene expression data for Acute Necrotizing Encephalopathy.

Pathways for Acute Necrotizing Encephalopathy

GO Terms for Acute Necrotizing Encephalopathy

Sources for Acute Necrotizing Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
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28 GO
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32 HPO
33 ICD10
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69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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