ANE1
MCID: ACT229
MIFTS: 13

Acute Necrotizing Encephalopathy Type 1 (ANE1)

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Necrotizing Encephalopathy Type 1

MalaCards integrated aliases for Acute Necrotizing Encephalopathy Type 1:

Name: Acute Necrotizing Encephalopathy Type 1 25
Postinfectious Acute Necrotizing Hemorrhagic Encephalopathy 25 71
Susceptibility to Infection-Induced Acute Encephalopathy 25
Autosomal Dominant Acute Necrotizing Encephalopathy 25
Susceptibility to Acute Necrotizing Encephalopathy 25
Encephalitis, Acute Necrotizing 71
Acute Necrotizing Encephalitis 25
Adane 25
Iiae3 25
Ane1 25

Classifications:



External Ids:

UMLS 71 C0338418 C3263959

Summaries for Acute Necrotizing Encephalopathy Type 1

Genetics Home Reference : 25 Acute necrotizing encephalopathy type 1, also known as susceptibility to infection-induced acute encephalopathy 3 or IIAE3, is a rare type of brain disease (encephalopathy) that occurs following a viral infection such as the flu. Acute necrotizing encephalopathy type 1 typically appears in infancy or early childhood, although some people do not develop the condition until adolescence or adulthood. People with this condition usually show typical symptoms of an infection, such as fever, cough, congestion, vomiting, and diarrhea, for a few days. Following these flu-like symptoms, affected individuals develop neurological problems, such as seizures, hallucinations, difficulty coordinating movements (ataxia), or abnormal muscle tone. Eventually, most affected individuals go into a coma, which usually lasts for a number of weeks. The condition is described as "acute" because the episodes of illness are time-limited. People with acute necrotizing encephalopathy type 1 develop areas of damage (lesions) in certain regions of the brain. As the condition progresses, these brain regions develop swelling (edema), bleeding (hemorrhage), and then tissue death (necrosis). The progressive brain damage and tissue loss results in encephalopathy. Approximately one-third of individuals with acute necrotizing encephalopathy type 1 do not survive their illness and subsequent neurological decline. Of those who do survive, about half have permanent brain damage due to tissue necrosis, resulting in impairments in walking, speech, and other basic functions. Over time, many of these skills may be regained, but the loss of brain tissue is permanent. Other individuals who survive their illness appear to recover completely. It is estimated that half of individuals with acute necrotizing encephalopathy type 1 are susceptible to recurrent episodes and will have another infection that results in neurological decline; some people may have numerous episodes throughout their lives. Neurological function worsens following each episode as more brain tissue is damaged.

MalaCards based summary : Acute Necrotizing Encephalopathy Type 1, also known as postinfectious acute necrotizing hemorrhagic encephalopathy, is related to acute necrotizing encephalitis and cerebral amyloid angiopathy, itm2b-related, 2. Affiliated tissues include brain.

Related Diseases for Acute Necrotizing Encephalopathy Type 1

Diseases in the Familial Acute Necrotizing Encephalopathy family:

Acute Necrotizing Encephalopathy Type 1

Diseases related to Acute Necrotizing Encephalopathy Type 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 acute necrotizing encephalitis 12.7
2 cerebral amyloid angiopathy, itm2b-related, 2 11.8
3 familial acute necrotizing encephalopathy 11.2
4 encephalitis 10.8
5 herpes simplex 10.3
6 cerebral amyloid angiopathy, cst3-related 10.3
7 dementia 10.3
8 quadriplegia 10.2
9 myelitis 10.2
10 neuromyelitis optica 10.2
11 transverse myelitis 10.2
12 acute transverse myelitis 10.2
13 alzheimer disease 10.1
14 thrombophilia due to thrombin defect 10.1
15 down syndrome 10.1
16 ocular motor apraxia 10.1
17 anxiety 10.1
18 generalized anxiety disorder 10.1
19 status epilepticus 10.1
20 thrombophilia 10.1
21 neuroblastoma 10.1
22 amyloidosis 10.1
23 pertussis 10.0
24 leigh syndrome 10.0
25 influenza 10.0
26 autoimmune disease 10.0
27 polycythemia vera 9.9
28 covid-19 9.9
29 acute chest syndrome 9.9
30 encephalomalacia 9.9
31 central nervous system disease 9.9
32 polycythemia 9.9
33 nervous system disease 9.9
34 sickle cell disease 9.9
35 herpes simplex encephalitis 9.9
36 encephalopathy 9.9

Graphical network of the top 20 diseases related to Acute Necrotizing Encephalopathy Type 1:



Diseases related to Acute Necrotizing Encephalopathy Type 1

Symptoms & Phenotypes for Acute Necrotizing Encephalopathy Type 1

Drugs & Therapeutics for Acute Necrotizing Encephalopathy Type 1

Search Clinical Trials , NIH Clinical Center for Acute Necrotizing Encephalopathy Type 1

Genetic Tests for Acute Necrotizing Encephalopathy Type 1

Anatomical Context for Acute Necrotizing Encephalopathy Type 1

MalaCards organs/tissues related to Acute Necrotizing Encephalopathy Type 1:

40
Brain

Publications for Acute Necrotizing Encephalopathy Type 1

Articles related to Acute Necrotizing Encephalopathy Type 1:

# Title Authors PMID Year
1
Familial Acute Necrotizing Encephalopathy: Evidence From Next Generation Sequencing of Digenic Inheritance. 61
32102593 2020

Variations for Acute Necrotizing Encephalopathy Type 1

Expression for Acute Necrotizing Encephalopathy Type 1

Search GEO for disease gene expression data for Acute Necrotizing Encephalopathy Type 1.

Pathways for Acute Necrotizing Encephalopathy Type 1

GO Terms for Acute Necrotizing Encephalopathy Type 1

Sources for Acute Necrotizing Encephalopathy Type 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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