Acute Necrotizing Pancreatitis

Categories: Endocrine diseases
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Aliases & Classifications for Acute Necrotizing Pancreatitis

MalaCards integrated aliases for Acute Necrotizing Pancreatitis:

Name: Acute Necrotizing Pancreatitis 11 14
Pancreatitis, Acute Necrotizing 43


External Ids:

Disease Ontology 11 DOID:0080998
MeSH 43 D019283

Summaries for Acute Necrotizing Pancreatitis

Disease Ontology: 11 An acute pancreatitis that is characterized by one or more areas of necrosis in the pancreas with varying degree of involvement of the surrounding tissues or organ systems.

MalaCards based summary: Acute Necrotizing Pancreatitis, also known as pancreatitis, acute necrotizing, is related to acute kidney failure and adult respiratory distress syndrome. An important gene associated with Acute Necrotizing Pancreatitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and NF-kappaB Signaling. The drugs Chlorhexidine and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, colon and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Related Diseases for Acute Necrotizing Pancreatitis

Diseases related to Acute Necrotizing Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 846)
# Related Disease Score Top Affiliating Genes
1 acute kidney failure 30.5 NPPA IL6 GPT
2 adult respiratory distress syndrome 30.4 TNF MPO IL6 IL1B IL10 CRP
3 neutrophilia, hereditary 30.3 MPO IL6 CRP
4 toxic shock syndrome 30.3 TNF IL6 IL1B IL10 CRP
5 alcohol use disorder 30.2 TNF IL6 IL1B GPT CRP
6 cholecystitis 30.1 GPT CRP CCK
7 nutritional deficiency disease 30.1 IL6 CRP CCK
8 necrotizing fasciitis 30.1 TNF IL6 IL1B CRP
9 testicular torsion 30.1 TNF MPO IL1B CRP
10 cartilage disease 30.1 TNF IL6 IL1B CRP
11 aortic aneurysm 30.1 TNF IL6 IL1B IL10 CRP
12 compartment syndrome 30.1 TNF IL6 GPT CRP
13 pancreatitis 30.0 TNF TMPRSS15 SST PNLIP IL6 IL1B
14 ischemia 30.0 TNF MPO IL6 ICAM1
15 parasitic helminthiasis infectious disease 29.9 TNF IL6 IL1B IL10
16 ileus 29.9 TNF IL6 IL1B IL10 ICAM1 CRP
17 kawasaki disease 29.9 TNF GPT CRP
18 disseminated intravascular coagulation 29.9 TNF IL6 IL10 GPT CRP
19 henoch-schoenlein purpura 29.8 TNF MPO IL6 ICAM1 CRP
20 appendicitis 29.8 TNF MPO IL6 IL1B IL10 CRP
21 hyperglycemia 29.8 TNF SST IL6 CCK
22 fascioliasis 29.8 IL1B IL10 GPT
23 bacterial infectious disease 29.7 TNF IL6 IL1B IL10 CRP
24 acute myocardial infarction 29.7 TNF NPPA IL6 IL10 CRP
25 duodenal ulcer 29.6 TNF SST MPO IL6 IL1B IL10
26 gastritis 29.5 TNF SST IL6 IL1B IL10
27 viral hepatitis 29.5 MPO IL6 ICAM1 GPT CRP
28 severe acute respiratory syndrome 29.5 TNF IL6 IL1B IL10 GPT CRP
29 leptin deficiency or dysfunction 29.5 TNF IL6 IL1B IL10 CRP CCK
30 intestinal perforation 29.5 TNF IL6 IL10 GPT CRP
31 hyperthyroidism 29.4 TNF SST IL6 GPT CRP
32 glucose intolerance 29.4 TNF SST IL6 GPT CRP
33 hypothyroidism 29.4 TNF SST GPT CRP
34 autoimmune disease 29.4 TNF IL6 IL1B IL10 ICAM1 CRP
35 aortic aneurysm, familial abdominal, 1 29.4 TNF IL6 IL1B IL10 ICAM1 CRP
36 acquired immunodeficiency syndrome 29.4 TNF IL6 IL1B IL10 ICAM1 CRP
37 acute pancreatitis 29.4 TNF TMPRSS15 SST PNLIP MPO IL6
38 ascaris lumbricoides infection 29.3 IL10 GPT
39 proteasome-associated autoinflammatory syndrome 1 29.2 TNF MPO IL6 IL1B IL10 ICAM1
40 peritonitis 29.2 TNF MPO IL6 IL1B IL10 ICAM1
41 respiratory failure 29.2 TNF MPO IL6 IL1B IL10 ICAM1
42 kidney disease 29.1 TNF NPPA IL6 IL1B IL10 ICAM1
43 neutropenia 29.1 TNF MPO IL6 IL1B IL10 GPT
44 cholangitis 28.9 TNF SST MPO IL6 IL10 ICAM1
45 myocardial infarction 28.7 TNF NPPA MPO IL6 IL1B IL10
46 gallbladder disease 1 10.4
47 external pathological resorption 10.4 TNF IL6
48 pancreatitis, hereditary 10.4
49 intestinal tuberculosis 10.4 TNF CRP
50 periodontitis, chronic 10.3 IL6 IL1B

Graphical network of the top 20 diseases related to Acute Necrotizing Pancreatitis:

Diseases related to Acute Necrotizing Pancreatitis

Symptoms & Phenotypes for Acute Necrotizing Pancreatitis

GenomeRNAi Phenotypes related to Acute Necrotizing Pancreatitis according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 IL10 IL1B MPO TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 ICAM1 IL10 IL1B MPO SST TNF
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.36 ICAM1

MGI Mouse Phenotypes related to Acute Necrotizing Pancreatitis:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.44 AOC1 CCK CRP ICAM1 IL10 IL1B

Drugs & Therapeutics for Acute Necrotizing Pancreatitis

Drugs for Acute Necrotizing Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 4 55-56-1 2713 9552079
Somatostatin Approved, Investigational Phase 4 38916-34-6, 51110-01-1 53481605 16129706
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185 44187
Metronidazole Approved Phase 4 443-48-1, 69198-10-3 4173
Dexmedetomidine Approved, Experimental, Vet_approved Phase 4 86347-14-0, 113775-47-6 68602 5311068
Meropenem Approved, Investigational Phase 4 119478-56-7, 96036-03-2 441130
Thymalfasin Investigational Phase 4 62304-98-7 16167214 16130571
8 Hormones Phase 4
9 Antiprotozoal Agents Phase 4
10 Antiparasitic Agents Phase 4
11 Hormone Antagonists Phase 4
12 Disinfectants Phase 4
13 Anti-Infective Agents, Local Phase 4
14 Dermatologic Agents Phase 4
15 Sulperazone Phase 4
16 Chlorhexidine gluconate Phase 4
17 Adjuvants, Immunologic Phase 4
18 Immunologic Factors Phase 4
19 Antibiotics, Antitubercular Phase 4
20 Anti-Bacterial Agents Phase 4
21 Anti-Infective Agents Phase 4
Streptokinase Approved, Investigational Phase 2, Phase 3 9002-01-1
23 Fibrinolytic Agents Phase 2, Phase 3
24 Pharmaceutical Solutions Phase 1
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
Fluorouracil Approved 51-21-8 3385
Indomethacin Approved, Investigational 53-86-1 3715
Pancrelipase Approved, Investigational 53608-75-6 8519
29 Cephalosporins
30 Antimetabolites
31 Immunosuppressive Agents
32 Cola
33 Analgesics
34 Antirheumatic Agents
35 Cyclooxygenase Inhibitors
36 Anti-Inflammatory Agents, Non-Steroidal
37 Analgesics, Non-Narcotic
38 Anti-Inflammatory Agents
39 Tocolytic Agents
40 Pancreatin

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Escalade or Deseacalade Antibiotic Use in Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
2 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Unknown status NCT02691598 Phase 4 Infusion
3 Thymosin Alpha 1 in the Prevention of Pancreatic Infection Following Acute Necrotizing Pancreatitis Completed NCT02473406 Phase 4 Thymosin Alpha 1;normal saline
4 A Multicentre, Randomised, Double-blind, Placebo-controlled, Study on the Use of Prophylactic Meropenem Therapy in Subjects With Severe Acute Necrotizing Pancreatitis Completed NCT00061438 Phase 4 meropenem
5 The Impact of Early Enteral Nutrition on the Clinical Outcomes of Severe Acute Pancreatitis Patients: A Randomized Control Trial Completed NCT00995098 Phase 4
6 Effect of Traditional Chinese Medicine on Gastrointestinal Function Recovery and Nutrition Support in Severe Acute Pancreatitis Unknown status NCT00508729 Phase 2, Phase 3 Qingyi granules
7 Evaluation of Effect of Integrated Treatment by Traditional Chinese and Western Medicine for Severe Acute Pancreatitis Unknown status NCT00506337 Phase 2, Phase 3 Qingyi granules
8 Phase 2/3 Study of Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis Completed NCT01977118 Phase 2, Phase 3 streptokinase
9 Randomized, Double-blind, Placebo Controlled Dose Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Doses (Intravenous Bolus) and Constant Intravenous Infusion Over 7 Days of GSK3335065 in Healthy Adult Subjects Terminated NCT03245619 Phase 1 GSK3335065;Placebo
10 Prophylactic Pancreatic Duct Stenting in Acute Necrotizing Pancreatitis: a Prospective Randomized Controlled Multicenter Study Unknown status NCT01767233
11 A Randomized Control Trial of Plastic Stents vs. NAGI Bi-flanged Metal Stent for Endoscopic Ultrasound Guided Drainage of Walled-off Necrosis Unknown status NCT04479228
12 A Randomized Controlled Trials on the Effect of Necrotic Cavity Lavage After Laparoscope-assisted Debridement for Patients With Infected Pancreatic Necrosis Unknown status NCT04275466
13 The Study of Laparoscopic-assisted Percutaneous Catheter-directed Drainage to Treat Early Severe Acute Pancreatitis in Chinese Population. Unknown status NCT02133014 0.5% 5-fluorouracil normal saline
14 Study of Plasma mitDNA in Predicting Pancreatic Necrosis in Acute Pancreatitis Unknown status NCT03788928
15 Risk Factors for ARDS in Patients With Acute Necrotizing Pancreatitis Completed NCT02641964
16 Acute Necrotizing Pancreatitis and Infected Pancreatic Necrosis: Can we Predict Primary Drainage Failure? Completed NCT03234166
17 Randomized Trial Examining the Impact of Pancreatic Duct Stent Placement in Patients With Acute Necrotizing Pancreatitis in the Prevention of Walled-off Necrosis Completed NCT03115918
18 Significance of Collections Around Colon in Patients With Acute Necrotizing Pancreatitis: a Prospective Study Completed NCT03411629
19 Risk Factors and Outcomes of Infected Pancreatic Necrosis: Retrospective Cohort of 148 Patients Admitted to the ICU for Acute Pancreatitis Completed NCT03253861
20 Videoendoscopic Drainage of Infected Pancreatic Collections Completed NCT00061269
21 Clinical Research on the Prophylactic Efficacy of Pancreatic Duct Stenting Combined With Rectal Indomethacin Drug on Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis Completed NCT03643900 rectal indomethacin
22 EUS-guided Drainage of Large Walled-off Pancreatic Necrosis Using Lumen Apposing Metal Stents or Standard Double Pigtail Technique. A Single-center, Open-label, Randomized, Superiority Trial Completed NCT04057846
23 Prospective, Trial Evaluating the Safety and Effectiveness of the Interscope Endorotor® System for Direct Endoscopic Necrosectomy of Walled Off Pancreatic Necrosis Completed NCT03694210
24 Randomized Multicenter Study Comparing Plastic Stents and Self-expanding Metallic Stents Used in the Eus-guided Transmural Drainage of Walled-off Pancreatic Necrosis. Completed NCT03100578
25 Randomized Trial Comparing Fully Covered, Self-Expanding Metal Stent and Plastic Stents for Endoscopic Ultrasound-guided Drainage of Walled-off Necrosis Completed NCT02685865
26 Radiological Predictors of Failure of Endoscopic Therapy or Need For Multiple Endoscopic Procedures in Patients With Walled Off Pancreatic Necrosis Completed NCT03801070
27 Minimally Invasive Surgery vs. Endoscopy Randomized (MISER) Trial for Necrotizing Pancreatitis Completed NCT02084537
28 EUS-guided Transenteric Drainage With a Novel Lumen-apposing Metal Stent for the Management of Pancreato-biliary Diseases: a Multi-national, Multicenter Prospective Study Completed NCT03002051
29 A Multicenter, Single-arm Study of Endoscopic Ultrasound-Guided Drainage of Walled-off Pancreatic Necrosis With Lumen-Apposing Metal Stents Completed NCT03525808
30 Early Percutaneous Continuous Irrigation Assisted Vacuum Drainage Combined With Transgastric Necrosectomy Using Lumen Apposing Metal Stents in Treatment of Severe Acute Pancreatitis Completed NCT05508828
31 Does Transmural Plastic Stenting Prevent the Recurrence of Pancreatic Fluid Collection After Metal Stent Removal in Walled Off Necrosis With Disconnected Pancreatic Duct Syndrome ? -Prospective Randomized Controlled Trial Completed NCT03436043
32 Molecular Analysis of Microbial DNA in Infected Necrotizing Pancreatitis Completed NCT01815489
33 Endoscopic Step-up Approach vs Aggressive Debridement of Large Pancreatic Walled-off Necrosis - A Single-center, Open-label, Randomized, Superiority Trial (ACCELERATE) Recruiting NCT05601687
34 Immediate Endoscopic Necrosectomy vs. On-demand Necroectomy in Infected Walled-off Pancreatic Necrosis Recruiting NCT05530772
35 Randomized Trial Comparing Immediate Endoscopic Necrosectomy vs. Step-up Endoscopic Interventions in Necrotizing Pancreatitis Recruiting NCT05043415
36 Observational Study of Patients Treated With Hot AXIOS® Prosthesis in Real Life Conditions - Recruiting NCT04782414
37 Fasciotens to Treat an Open Abdomen - a Prospective Cohort Study Recruiting NCT04033614
38 Dual-scopic Pancreatic Necrosectomy (DPN): Laparoscopic Pancreatic Necrosectomy (LPN) and Nephroscopic Pancreatic Necrosectomy (NPN) Recruiting NCT04443595
39 Immediate Necrosectomy vs. Step-up Approach After EUS-guided Drainage of Walled-off Necrosis: a Multicenter Randomized Controlled Trial (WONDER-01) Recruiting NCT05451901
40 coMpliAnce With evideNce-based cliniCal Guidelines in the managemenT of Acute biliaRy pancreAtitis Recruiting NCT04747990
42 Direct Endoscopic Necrosectomy Versus Endoscopic Step-up Approach After Endoscopic Drainage of Walled-off Pancreatic Necrosis (WON) Recruiting NCT05252897
43 Use of the ABTHERA ADVANCE™ Open Abdomen Dressing in Patients With Necrotizing Pancreatitis Recruiting NCT04986943
44 Open Surgery for Necrotizing Pancreatitis in the Era of Minimally Invasive Approach: 10-year Experience in a High-volume Centre Active, not recruiting NCT04673552
45 Endoscopic Ultrasound-guided Drainage Using Lumen-apposing Metal Stent With or Without Coaxial Plastic Stent for Treatment of Walled-off Pancreatic Necrosis: a Prospective Randomised Study Active, not recruiting NCT03923686
46 A Randomized Trial Comparing Direct Endoscopic Necrosectomy vs. Step-up Transluminal Endoscopic Interventions in Infected Necrotizing Pancreatitis (DESTIN) Active, not recruiting NCT04113499
47 Management of Portoplenomesenteric Vein Thrombosis in Patients With Acute Pancreatitis : an Observational Study Not yet recruiting NCT04642794
48 Timing of Transmural Stent Removal in Necrotizing Pancreatitis Undergoing Endoscopic Transmural Necrosectomy: A Randomized Controlled Study Not yet recruiting NCT04963868
49 Randomized, Multi-Center, Comparative and Cost Effectiveness Study of a Lumen- Apposing, Covered, Self-Expanding Metal Stent (Axios™) Versus Multiple Double Pigtail Stents in the Management of Walled Off Pancreatic Necrosis Terminated NCT02673541
50 Endoscopic Large Caliber Drainage vs. Complete Necrosectomy for Treatment of Walled-off Pancreatic Necrosis: A Prospective, Randomized Noninferiority Trial. Withdrawn NCT02564965

Search NIH Clinical Center for Acute Necrotizing Pancreatitis

Cochrane evidence based reviews: pancreatitis, acute necrotizing

Genetic Tests for Acute Necrotizing Pancreatitis

Anatomical Context for Acute Necrotizing Pancreatitis

Organs/tissues related to Acute Necrotizing Pancreatitis:

MalaCards : Pancreas, Colon, Lung, Liver, Adrenal Gland, Neutrophil, Kidney

Publications for Acute Necrotizing Pancreatitis

Articles related to Acute Necrotizing Pancreatitis:

(show top 50) (show all 1118)
# Title Authors PMID Year
Disconnected pancreatic duct syndrome in patients with necrotizing pancreatitis. 62
36438587 2023
Predicting need for intervention in acute necrotizing pancreatitis following discharge- A single center experience in 525 patients. 62
36371404 2022
An Unexpected Diagnosis Underlying Acute Necrotizing Pancreatitis. 62
35863529 2022
Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase. 62
36376282 2022
Disconnected pancreatic duct syndrome. Endoscopic approach. 62
36281925 2022
Extensive necrotic abscesses invading the back muscles in acute necrotizing pancreatitis: A case report. 62
35680511 2022
The effect of procalcitonin and immature granulocyte ratio in predicting the development of acute necrotizing pancreatitis: evidence from 582 cases. 62
36314322 2022
COVID-19 treatment: A potential cause of acute pancreatitis. 62
36285030 2022
Simple scoring for acute necrotizing pancreatitis: mortality in acute necrotizing pancreatitis during admission (MANP-A). 62
36061165 2022
[65/m-Upper abdominal pain after ERC, "acute necrotizing pancreatitis" : Preparation course anesthesiological intensive care medicine: case 23]. 62
35925176 2022
36427847 2022
Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis. 62
36155394 2022
Pancreatic necrosis volume for predicting readmission and reintervention in acute necrotizing pancreatitis. 62
35878514 2022
Identification of early predictors for infected necrosis in acute pancreatitis. 62
36057565 2022
Necrotizing pancreatitis complicated by retroperitoneal emphysema: two case reports. 62
36163599 2022
Percutaneous direct endoscopic pancreatic necrosectomy. 62
36157371 2022
COVID 19 induced acute pancreatitis in patients with renal impairment: report of five cases. 62
35471693 2022
Percutaneous Catheter Drainage in Acute Infected Necrotizing Pancreatitis: A Real-World Experience at a Tertiary Care Hospital in North India. 62
36120245 2022
A remote attack to the distal colon from the acute necrotizing pancreatitis. 62
36041903 2022
Acute Necrotizing Pancreatitis Complicated by Multiple Splanchnic Venous Thromboses and Bilateral Renal Infarctions in a Patient With Recent COVID-19 Infection: A Case Report. 62
36127973 2022
Abbreviated non-enhanced magnetic resonance imaging in patients with acute necrotizing pancreatitis. 62
35507068 2022
Necrotizing soft tissue infection of the upper leg as first presentation of necrotizing pancreatitis: a case report. 62
35833907 2022
Wall maturation in necrotic collections in acute pancreatitis: a computed tomography based evaluation. 62
35770279 2022
Completion Pancreatectomy After Pancreatoduodenectomy: Who Needs It? 62
35781509 2022
Endoscopic necrosectomy - when the gastroenterologist faces his greatest nightmare. 62
34779212 2022
Effect of TRAF6 in acute pancreatitis-induced intestinal barrier injury via TLR4/NF-κB signal pathway. 62
35405432 2022
Endoscopic management of pancreatic fluid collections with disconnected pancreatic duct syndrome. 62
35708366 2022
A Rare Case Report of Intra-abdominal Mucormycosis Complicating Acute Pancreatitis. 62
35836631 2022
Fascioliasis complicated by acute necrotizing pancreatitis in an Ethiopian child - a case report on a rare complication of a rarely reported emerging disease. 62
35755466 2022
A huge preperitoneal collection following acute necrotizing pancreatitis: A case report and the management approach. 62
35734743 2022
Pseudoaneurysm of the cystic artery after acute necrotizing pancreatitis. 62
36065811 2022
Early prediction of acute necrotizing pancreatitis by artificial intelligence: a prospective cohort-analysis of 2387 cases. 62
35552440 2022
COVID-19 Associated Acute Pancreatitis: A Case Series from India. 62
35638541 2022
Disconnected pancreatic duct syndrome and outcomes of endoscopic ultrasound-guided treatment of pancreatic fluid collections: Systematic review and meta-analysis. 62
34544204 2022
Necrotizing pancreatitis with portal vein thrombosis in young patient with COVID-19. 62
35344770 2022
Historical Perspective and Medical Maladies of Alexander the Great. 62
35535285 2022
Coronavirus disease 2019 (COVID 19) induced acute necrotizing pancreatitis in a female child: A case report. 62
35371474 2022
Pancreatic hemorrhage contributes to late mortality in patients with acute necrotizing pancreatitis. 62
35034847 2022
Possibilities of Endovascular Hemostasis in Treatment of Pancreatic Bleeding. 62
35891772 2022
Radiological criteria for disconnected pancreatic duct syndrome: a targeted literature review. 62
35051345 2022
A Case Series of Late Gastrointestinal Fistulization in 16 Patients with Walled-Off Necrosis. 62
33651255 2022
Malignant Hypertension Complicated with Necrotizing Pancreatitis After Starting Treatment: A Case Report. 62
35221328 2022
Routine laboratory parameters in patients with necrotizing pancreatitis by the time of operative pancreatic debridement: Food for thought. 62
35126864 2022
Analysis of the clinical characteristics of olanzapine-induced acute pancreatitis. 62
35510088 2022
[Etiology and pathogenesis of infected pancreatic necrosis]. 62
35920228 2022
Value of neutrophil-lymphocyte ratio in evaluating response to percutaneous catheter drainage in patients with acute pancreatitis. 62
35071509 2022
Disconnected Pancreatic Duct Syndrome: A Case Series. 62
35990868 2022
Gut microbiota on admission as predictive biomarker for acute necrotizing pancreatitis. 62
36105818 2022
36472260 2022
A Case Report of Acute Necrotizing Pancreatitis after COVID-19 Infection. 62
35935668 2022

Variations for Acute Necrotizing Pancreatitis

Expression for Acute Necrotizing Pancreatitis

Search GEO for disease gene expression data for Acute Necrotizing Pancreatitis.

Pathways for Acute Necrotizing Pancreatitis

Pathways related to Acute Necrotizing Pancreatitis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
Show member pathways
12.54 TNF MPO IL6 IL1B IL10
2 12.48 TNF MPO IL1B IL10
3 12.06 IL10 IL1B IL6 TNF
4 11.97 TNF SST IL6 IL1B IL10
5 11.93 TNF MPO IL6 IL10
6 11.92 TNF IL6 IL1B ICAM1
Show member pathways
11.85 IL10 IL1B IL6 TNF
8 11.8 TNF IL1B IL10
9 11.73 TNF IL1B IL10
10 11.69 TNF IL6 IL1B ICAM1
11 11.69 TNF IL6 IL1B IL10 ICAM1
12 11.66 NPPA IL6 IL10
13 11.66 TNF IL6 IL1B IL10
14 11.63 TNF IL6 IL10 CRP
15 11.62 TNF IL6 IL1B
Show member pathways
11.58 TNF IL6 IL10
Show member pathways
11.56 TNF IL6 IL1B ICAM1
18 11.53 IL10 IL1B IL6 TNF
19 11.52 TNF IL10 ICAM1
20 11.5 ICAM1 IL10 IL6 TNF
21 11.45 TNF IL6 IL1B
22 11.29 TNF IL6 IL1B
23 11.25 TNF IL6 IL1B
24 11.23 TNF IL6 ICAM1
25 11.21 TNF IL6 IL1B
26 11.18 TNF IL6 IL10
27 11.17 TNF IL6 IL1B IL10
28 11.03 IL6 IL1B IL10
29 10.98 TNF IL6 CRP
30 10.92 TNF IL6 IL1B IL10
31 10.74 IL6 IL1B
32 10.69 TNF IL6 IL1B IL10 ICAM1
33 10.46 TNF MPO IL1B ICAM1
Show member pathways
10.33 TNF IL6

GO Terms for Acute Necrotizing Pancreatitis

Cellular components related to Acute Necrotizing Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TNF SST PNLIP NPPA MPO IL6
2 extracellular space GO:0005615 9.78 AOC1 CCK CELA1 CELA3B CRP GPT

Biological processes related to Acute Necrotizing Pancreatitis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 10.15 TNF IL6 IL1B IL10
2 defense response to Gram-positive bacterium GO:0050830 10.13 TNF IL6 IL1B CRP
3 positive regulation of DNA-binding transcription factor activity GO:0051091 10.11 IL10 IL1B IL6 TNF
4 response to glucocorticoid GO:0051384 10.09 TNF IL6 IL10
5 regulation of insulin secretion GO:0050796 10.07 TNF IL6 IL1B
6 response to activity GO:0014823 10.06 TNF IL6 IL10
7 response to lipopolysaccharide GO:0032496 10.05 IL10 IL1B MPO TNF
8 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.01 TNF IL6 IL10
9 positive regulation of chemokine production GO:0032722 9.97 TNF IL6 IL1B
10 liver regeneration GO:0097421 9.93 TNF IL6 IL10
11 negative regulation of neurogenesis GO:0050768 9.91 TNF IL6 IL1B
12 negative regulation of cytokine production involved in immune response GO:0002719 9.9 TNF IL10
13 positive regulation of fever generation GO:0031622 9.86 TNF IL1B
14 sequestering of triglyceride GO:0030730 9.85 TNF IL1B
15 leukocyte migration GO:0050900 9.8 TNF IL1B ICAM1
16 positive regulation of glial cell proliferation GO:0060252 9.8 TNF IL6 IL1B
17 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.78 TNF IL1B
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.73 TNF IL1B IL10
19 chronic inflammatory response to antigenic stimulus GO:0002439 9.71 IL10 TNF
20 response to gold nanoparticle GO:1990268 9.67 MPO TNF
21 positive regulation of neuroinflammatory response GO:0150078 9.63 TNF IL6 IL1B
22 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
23 vascular endothelial growth factor production GO:0010573 9.1 TNF IL6 IL1B

Sources for Acute Necrotizing Pancreatitis

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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