MCID: ACT118
MIFTS: 27

Acute Non Lymphoblastic Leukemia

Categories: Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Non Lymphoblastic Leukemia

MalaCards integrated aliases for Acute Non Lymphoblastic Leukemia:

Name: Acute Non Lymphoblastic Leukemia 53
Leukemia, Myelocytic, Acute 72

Classifications:



External Ids:

UMLS 72 C0023467

Summaries for Acute Non Lymphoblastic Leukemia

MalaCards based summary : Acute Non Lymphoblastic Leukemia, also known as leukemia, myelocytic, acute, is related to leukemia, acute myeloid and lymphocytic leukemia, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Acute Non Lymphoblastic Leukemia is ABCB1 (ATP Binding Cassette Subfamily B Member 1). The drugs Gemtuzumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and myeloid, and related phenotype is hearing/vestibular/ear.

Related Diseases for Acute Non Lymphoblastic Leukemia

Diseases related to Acute Non Lymphoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 11.9
2 lymphocytic leukemia 10.9
3 leukemia 10.7
4 myelodysplastic syndrome 10.3
5 acute leukemia 10.2
6 myeloid sarcoma 10.2
7 graft-versus-host disease 10.1
8 hepatic veno-occlusive disease 10.1
9 sarcoma 10.1
10 disseminated intravascular coagulation 10.1
11 neutropenia 10.1
12 thrombocytopenia 10.1
13 spindle cell sarcoma 10.1
14 myeloid leukemia 10.1
15 47,xyy 10.1
16 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.1
17 chromosomal triplication 10.1
18 porphyria cutanea tarda 9.9
19 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
20 myeloma, multiple 9.9
21 osteogenic sarcoma 9.9
22 polycythemia vera 9.9
23 acute promyelocytic leukemia 9.9
24 leukemia, acute lymphoblastic 9.9
25 lymphoma 9.9
26 porphyria 9.9
27 bronchiolitis 9.9
28 arthropathy 9.9
29 childhood leukemia 9.9
30 polycythemia 9.9
31 exophthalmos 9.9
32 intracranial hypertension 9.9
33 alopecia 9.9
34 hypereosinophilic syndrome 9.9
35 acute graft versus host disease 9.9
36 acute respiratory distress syndrome 9.9
37 myelodysplastic syndrome with excess blasts 9.9
38 triploidy 9.9
39 refractory anemia with excess blasts in transformation 9.9
40 refractory anemia 9.9
41 hematologic cancer 9.4 CSF1 ABCB1
42 ovarian cancer 9.2 CSF1 ABCB1

Graphical network of the top 20 diseases related to Acute Non Lymphoblastic Leukemia:



Diseases related to Acute Non Lymphoblastic Leukemia

Symptoms & Phenotypes for Acute Non Lymphoblastic Leukemia

UMLS symptoms related to Acute Non Lymphoblastic Leukemia:


angina pectoris, edema, chest pain

MGI Mouse Phenotypes related to Acute Non Lymphoblastic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 8.62 ABCB1 CSF1

Drugs & Therapeutics for Acute Non Lymphoblastic Leukemia

Drugs for Acute Non Lymphoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Gemtuzumab Phase 4
2 Antineoplastic Agents, Immunological Phase 4
3
Mercaptopurine Approved Phase 3 50-44-2 667490
4
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
5
Cladribine Approved, Investigational Phase 3 4291-63-8 20279
6
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
7
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
8
Posaconazole Approved, Investigational, Vet_approved Phase 3 171228-49-2 147912
9
Daunorubicin Approved Phase 3 20830-81-3 30323
10
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492 6473866
11
Sirolimus Approved, Investigational Phase 3 53123-88-9 6436030 5284616 46835353
12
leucovorin Approved Phase 3 58-05-9 143 6006
13
Everolimus Approved Phase 3 159351-69-6 6442177 70789204
14
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
15
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
17
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
18
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
19
Etoposide Approved Phase 3 33419-42-0 36462
20
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
21
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
22
Melphalan Approved Phase 3 148-82-3 460612 4053
23
Vidarabine Approved, Investigational Phase 3 24356-66-9 21704 32326
24
Busulfan Approved, Investigational Phase 3 55-98-1 2478
25
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
26 Anti-Bacterial Agents Phase 3
27 Antibiotics, Antitubercular Phase 3
28 Topoisomerase Inhibitors Phase 3
29 14-alpha Demethylase Inhibitors Phase 3
30 Hormones Phase 3
31 Antifungal Agents Phase 3
32 Steroid Synthesis Inhibitors Phase 3
33 Hormone Antagonists Phase 3
34 Cytochrome P-450 Enzyme Inhibitors Phase 3
35 Antiparasitic Agents Phase 3
36 Antiprotozoal Agents Phase 3
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
38 Antineoplastic Agents, Phytogenic Phase 3
39 Folic Acid Antagonists Phase 3
40 Vitamin B9 Phase 3
41 Folate Phase 3
42 Nucleic Acid Synthesis Inhibitors Phase 3
43 Vitamin B Complex Phase 3
44 Dermatologic Agents Phase 3
45 Calcineurin Inhibitors Phase 3
46 Tubulin Modulators Phase 3
47 Analgesics Phase 3
48 Antiemetics Phase 3
49 Gastrointestinal Agents Phase 3
50 Anti-Inflammatory Agents Phase 3

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 A Phase IV Study of Corticosteroids As Prophylaxis for Infusion-Related Adverse Events to Mylotarg® in Patients With Acute Myelogenous Leukemia (AML) Completed NCT00304447 Phase 4 Mylotarg
2 Randomized Comparison Between Two Dose Levels of Daunorubicin and Between One Versus Two Cycles of Induction Therapy for Adult Patients With Acute Myeloid Leukemia ≤65 Years Unknown status NCT02140242 Phase 3 study part 1 - dose daunorubicin
3 A Randomized Study of Two Doses Gemtuzumab Ozogamicin vs. A Two-year Maintenance With Atra Plus Chemotherapy as Post-consolidation Treatment for Intermediate and High-risk Adult Patients With Acute Promyelocytic Leukemia (Apl) Completed NCT00962767 Phase 3 gemtuzumab ozogamicin;ATRA plus 6-MP and MTX
4 A Randomized Controlled Trial of Posaconazole (SCH 56592) vs. Standard Azole Therapy for the Prevention of Invasive Fungal Infections Among High-Risk Neutropenic Patients Completed NCT00044486 Phase 3 Posaconazole oral suspension
5 A Phase III Randomized, Multicenter Trial Comparing Sirolimus/Tacrolimus With Tacrolimus/Methotrexate as Graft-versus-Host Disease (GVHD) Prophylaxis After HLA-Matched, Related Peripheral Blood Stem Cell Transplantation (BMT CTN #0402) Completed NCT00406393 Phase 3 Tacrolimus;Methotrexate;Sirolimus
6 A Collaborative Trial for the Treatment of Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplasia Completed NCT00136084 Phase 3 Cladribine, Cyclophosphamide, Cytarabine, Daunorubicin, Dexamethasone;Etoposide, Cytarabine, Gemtuzumab, L-asparaginase, Mercaptopurine, methotrexate, Mitoxantrone, Prednisone, Vincristine
7 A Randomized, Multi-Center, Phase III Study of Allogeneic Stem Cell Transplantation Comparing Regimen Intensity in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia (BMT CTN #0901) Terminated NCT01339910 Phase 3 Fludarabine and Busulfan;Fludarabine and Melphalan;Busulfan and Fludarabine;Busulfan and Cyclophosphamide;Cyclophosphamide and Total Body Irradiation
8 Phase II Study of Cladribine, High-dose Cytarabine and Idarubicin in Patients With Relapsed Acute Myeloid Leukemia Unknown status NCT00126321 Phase 2 cladribine
9 Autologous Bone Marrow Transplantation for Acute Non-Lymphoblastic Leukemia During First or Subsequent Remission Completed NCT00186381 Phase 2
10 A Phase II, Open Label Study of Clofarabine in Pediatric Patients With Refractory or Relapsed Acute Myelogenous Leukemia Completed NCT00042354 Phase 2 clofarabine (IV formulation)
11 Risk Adapted Treatment for Primary AML in Adults up to the Age of 60 Years. Completed NCT01716793 Phase 2 Ara-C
12 A Single Arm, Multicenter Phase II Trial of Transplants of HLA-Matched, CD34+ Enriched, T Cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With AML in First or Second Morphologic Complete Remission (BMT CTN #0303) Completed NCT00201240 Phase 2
13 Clofarabine in Combination With Cytarabine and Total Body Irradiation Followed by Allogeneic Stem Cell Transplantation in Children With Acute Lymphoblastic Leukemia and Acute Non-Lymphoblastic Leukemia Completed NCT00529360 Phase 1, Phase 2 Clofarabine;Clofarabine
14 Risk Adapted Treatment for Primary AML in Adults, Based on Genetics and Minimal Residual Disease (MRD) in Patients up to the Age of 70 Years. Completed NCT01723657 Phase 2 Ara-C;G-CSF
15 Randomized Trial of Unmanipulated Versus Expanded Cord Blood Completed NCT00067002 Phase 2 Rituxan;Melphalan;Thiotepa;Fludarabine;Cyclophosphamide;Mesna
16 A Phase II Study of Maintenance With Azacitidine in MDS Patients Achieving Complete or Partial Remission (CR or PR) After Intensive Chemotherapy Terminated NCT00446303 Phase 2 Azacitidine
17 Phase II Study: HSCT Using CD34 Selected Mismatched Related Donor and One Umbilical Cord Unit Terminated NCT01050946 Phase 2
18 A Phase I Clinical Trial of Vorinostat in Combination With Decitabine in Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome Completed NCT00479232 Phase 1 vorinostat;decitabine
19 Multicenter Study of 9-AC in Refractory Leukemia Completed NCT00251368 Phase 1 9-Aminocamptothecin (9-AC)
20 A Clinical Trial of Donor-derived WT1 Specific T Cells for Prevention of Relapse in Combination With Multiple Pathogen Specific T Cells for Prevention of Infection in Patients Undergoing Allogeneic Haemopoietic Stem Cell Transplant for AML Recruiting NCT02895412 Phase 1
21 Anti-Leukemic Dendritic Cell Activated Donor Lymphocytes for Therapy of Relapsed Leukemia After Allogeneic Stem Cell Therapy Terminated NCT00048100 Phase 1
22 Use of the MiCK Assay for Apoptosis to Predict Complete Remission in Acute Myeloid Leukemia Completed NCT00286845 Standard Chemotherapy
23 Barriers to Patient Enrollment Onto Frontline Therapeutic Clinical Trials and Development of Intervention Strategies to Increase the Proportion of Enrollment Completed NCT00002485
24 AML Treatment in Untreated Adult Patients According to EORTC-GIMEMA Protocols AML8 and AML10 Recruiting NCT00449319 Daunorubicine

Search NIH Clinical Center for Acute Non Lymphoblastic Leukemia

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Cyclophosphamide
Etoposide
etoposide phosphate
Idarubicin
Idarubicin Hydrochloride
Mitoxantrone
Mitoxantrone Hydrochloride

Genetic Tests for Acute Non Lymphoblastic Leukemia

Anatomical Context for Acute Non Lymphoblastic Leukemia

MalaCards organs/tissues related to Acute Non Lymphoblastic Leukemia:

41
Bone, Bone Marrow, Myeloid, T Cells, Liver, Testes, Lung

Publications for Acute Non Lymphoblastic Leukemia

Articles related to Acute Non Lymphoblastic Leukemia:

(show top 50) (show all 262)
# Title Authors PMID Year
1
Therapy-related myelodysplastic syndrome/acute leukemia after multiple myeloma in the era of novel agents. 38
25284489 2015
2
Childhood cancer incidence and survival 1985-2009, Khon Kaen, Thailand. 38
25292101 2014
3
Leptin promoter G-2548A genotypes and associated serum leptin levels in childhood acute leukemia at diagnosis and under high-dose steroid therapy. 38
21955253 2012
4
[Complex chromosome damages in patients with recurrent acute leukemias after allogeneic hematopoietic stem cell transplantations]. 38
22994092 2012
5
Childhood cancer incidence and survival 2003-2005, Thailand: study from the Thai Pediatric Oncology Group. 38
22296359 2011
6
Incidence of bacteremias and invasive mycoses in children with acute non-lymphoblastic leukemia: results from a multi-center Italian study. 38
20680968 2010
7
Detection of myeloperoxidase activity in primary leukemic cells by an enhanced chemiluminescent assay for differentiation between acute lymphoblastic and non-lymphoblastic leukemia. 38
19298796 2009
8
Immunoproliferative small intestinal disease versus colonic monoblastic sarcoma in a 2-year-old boy. 38
19942975 2009
9
Trends in 5- and 10-year survival after diagnosis with childhood hematologic malignancies in the United States, 1990-2004. 38
18780868 2008
10
[Induced acute non-lymphoblastic leukemia and prognostic significance of cytogenetic abnormalities: trisomy in chromosome 8, inv(16)(p13q22), and t(8;21)(q22;q22)]. 38
18822849 2008
11
[MIC categorization of acute lymphoblastic leukemia with myeloid surface antigen expression]. 38
18457267 2007
12
Nitazoxanide or CD3+/CD4+ lymphocytes for recovery from severe Cryptosporidium infection after allogeneic bone marrow transplant? 38
17239134 2007
13
[Rheumatological symptoms masking neoplasm in children]. 38
18350715 2007
14
[Clinical significance of CD117/CD34 co-expression in adult patients with acute leukemia]. 38
16764777 2006
15
Spleen and lung involvement by Acinetobacter calcoaceticus bacteremia mimicking deep fungal infection in a child with acute non-lymphoblastic leukemia. 38
16078222 2006
16
[Study on the relationship between polymorphisms of Cyp1A1, GSTM1, GSTT1 genes and the susceptibility to acute leukemia in the general population of Hunan province]. 38
16676594 2005
17
Temporal trends in the incidence of childhood leukemia, lymphomas and solid tumors in north-west Italy, 1967-2001. A report of the Childhood Cancer Registry of Piedmont. 38
16154843 2005
18
Growth patterns and final height of survivors of childhood leukemia. 38
15237705 2004
19
Population-based survival after childhood cancer diagnosed during 1970-98: a report from the Childhood Cancer Registry of Piedmont, Italy. 38
12969805 2003
20
Family history of autoimmune thyroid disease and childhood acute leukemia. 38
12540505 2003
21
[Efficacy of idarubicin in the treatment of childhood acute non-lymphoblastic leukemia: report of Polish Pediatric Leukemia/Lymphoma Study Group]. 38
14575003 2003
22
Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation. 38
12234279 2002
23
Langerhans cell histiocytosis with transformation to acute leukemia showing 45,X, t(8; 21), 5q-, -Y karyotype. 38
12400613 2002
24
Utility of WT1 as a reliable tool for the detection of minimal residual disease in children with leukemia. 38
12007019 2002
25
Red cells with paroxysmal nocturnal hemoglobinuria-phenotype in patients with acute leukemia. 38
12186694 2002
26
Consecutive IL-2 and IFN-a2a Maintenance in a Patient with Acute Non-lymphoblastic Leukemia and Renal Cell Cancer. 38
27264260 2001
27
[Invasive rhinocerebral aspergillosis occurred during myelosuppressive phase after chemotherapy: a case report and literature review]. 38
11877100 2001
28
[Ocular infiltration in the anterior chamber in a female infant with acute non-lymphoblastic leukemia]. 38
11412473 2001
29
[Apoptosis and proliferative activity of bone marrow cells in patients with aplastic syndromes as evidenced by trephine biopsy]. 38
11523410 2001
30
[Detection of hypermethylation of p15 gene in patients with acute leukemia by polymerase chain reaction]. 38
11876990 2000
31
[Childhood acute myeloblastic leukemias. Report of 21 cases]. 38
11026819 2000
32
[Importance of immunophenotyping of leukemia myelocytic acute]. 38
10770904 2000
33
[Pure red cell aplasia after allogeneic peripheral blood stem cell transplantation: a case report and literature review]. 38
11721433 1999
34
[Changes in the long arm of chromosome 3 (3q) in malignant myeloid hemopathies. A study of 10 cases]. 38
10353117 1999
35
[Measurement of soluble Fas in patients with hematological malignancy]. 38
11938782 1999
36
[Immunomodulator Cycloferon in the comprehensive treatment of patients with acute non-lymphoblastic leukemia]. 38
10532100 1999
37
Allogeneic peripheral blood stem cell transplantation in acute non-lymphoblastic leukemia. 38
10414235 1998
38
[Interstitial 9q deletion: a primary change in acute non-lymphoblastic leukemia?]. 38
9868338 1998
39
Acute non-lymphoblastic leukemia with an unusual chromosomal abnormality in a patient with advanced AIDS. 38
9792401 1998
40
[Low-dose oral etoposide and subcutaneous injection of low-dose cytosine arabinoside (Et-A non i.v.) with or without minimum anthracycline for refractory acute non-lymphoblastic leukemia]. 38
9725056 1998
41
Effect of serum from thrombocytopenic patients on platelet count in blood of mice. 38
9720349 1998
42
Total-body irradiation before bone marrow transplantation for acute leukemia in first or second complete remission. Results and prognostic factors in 326 consecutive patients. 38
9487372 1998
43
The role of impaired transport in (pre)clinical resistance to methotrexate: insights on new antifolates. 38
17092808 1998
44
[Cytoprotective effect of amifostine in children during induction therapy according to BFM-83: report on cases]. 38
10731972 1998
45
Immunophenotypic patterns and cytogenetic anomalies in acute non-lymphoblastic leukemia subtypes: a prospective study of 432 patients. 38
9436918 1998
46
[Sepsis caused by Pseudomonas aeruginosa as the complication of induction treatment of acute non-lymphoblastic leukemia in a 10-year old girl]. 38
10731988 1998
47
[Secondary head and neck osteosarcoma following treatment of undifferentiated nasopharyngeal neoplasms (UCNT)]. 38
9587363 1997
48
Acute rhabdomyolysis and myonecrosis complicating aeromonas bacteremia in neutropenic patients with hematologic malignancies: report of two cases. 38
9499669 1997
49
Detection of CBFbeta/MYH11 fusion transcripts in acute myeloid leukemia: heterogeneity of cytological and molecular characteristics. 38
9180286 1997
50
Risk of secondary leukemia after treatment with etoposide (VP-16) for Langerhans' cell histiocytosis in Italian and Austrian-German populations. 38
9096658 1997

Variations for Acute Non Lymphoblastic Leukemia

Expression for Acute Non Lymphoblastic Leukemia

Search GEO for disease gene expression data for Acute Non Lymphoblastic Leukemia.

Pathways for Acute Non Lymphoblastic Leukemia

GO Terms for Acute Non Lymphoblastic Leukemia

Sources for Acute Non Lymphoblastic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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