MCID: ACT077
MIFTS: 22

Acute Orbital Inflammation

Categories: Eye diseases

Aliases & Classifications for Acute Orbital Inflammation

MalaCards integrated aliases for Acute Orbital Inflammation:

Name: Acute Orbital Inflammation 12 15
Acute Inflammation of Orbit 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11230
ICD9CM 36 376.0 376.00
SNOMED-CT 69 20551005
ICD10 34 H05.0 H05.00
UMLS 74 C0155256

Summaries for Acute Orbital Inflammation

MalaCards based summary : Acute Orbital Inflammation, also known as acute inflammation of orbit, is related to orbital cellulitis and orbital periostitis. An important gene associated with Acute Orbital Inflammation is RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1), and among its related pathways/superpathways is NF-kappaB Signaling. Affiliated tissues include eye, and related phenotypes are cardiovascular system and mortality/aging

Related Diseases for Acute Orbital Inflammation

Diseases in the Acute Orbital Inflammation family:

Chronic Orbital Inflammation

Diseases related to Acute Orbital Inflammation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 orbital cellulitis 28.6 BIN1 COX5A CRP HCK IL1RN IRF6
2 orbital periostitis 11.2
3 orbital osteomyelitis 11.2
4 orbital tenonitis 11.2
5 intracranial sinus thrombosis 10.4 PGBD1 RHNO1
6 mastoiditis 10.4 CRP RHNO1
7 parasitic ichthyosporea infectious disease 10.4 NCAM1 RHNO1
8 dental abscess 10.3 BIN1 CRP
9 rhinosporidiosis 10.3 NCAM1 RHNO1
10 orbital disease 10.3 CRP PGBD1 RHNO1
11 pleural empyema 10.3 CRP PGBD1
12 rhinoscleroma 10.3 NCAM1 RHNO1
13 pericoronitis 10.3 CRP NCAM1
14 sphenoid sinusitis 10.3 CRP NT5C2 RHNO1
15 cryopyrin-associated periodic syndrome 10.3 CRP IL1RN
16 intestinal perforation 10.3 CRP NCAM1
17 hyper-igd syndrome 10.3 CRP IL1RN
18 schnitzler syndrome 10.3 CRP IL1RN
19 mitochondrial disorders 10.2 COX5A OPA1
20 cartilage disease 10.2 CRP IL1RN
21 acute cholangitis 10.2 CRP IL1RN NT5C2
22 listeria meningitis 10.2 LTA RHNO1
23 angiomyoma 10.2 HMGA2 NCAM1
24 ethmoid sinusitis 10.2 CRP RHNO1
25 spondylitis 10.2 CRP IL1RN LTA
26 juvenile rheumatoid arthritis 10.2 CRP IL1RN LTA
27 chronic maxillary sinusitis 10.1 IRF6 PDPN RHNO1
28 intracranial abscess 10.1 BIN1 CRP ERAS
29 extrahepatic bile duct adenocarcinoma 10.0 NCAM1 SDC1
30 cavernous sinus thrombosis 10.0 PGBD1 RHNO1 SDC1
31 cecal disease 10.0 CRP HCK
32 miliaria 9.9 PDPN SDC1
33 solitary osseous plasmacytoma 9.8 NCAM1 SDC1
34 herpes zoster 9.8
35 herpes zoster ophthalmicus 9.8

Graphical network of the top 20 diseases related to Acute Orbital Inflammation:



Diseases related to Acute Orbital Inflammation

Symptoms & Phenotypes for Acute Orbital Inflammation

MGI Mouse Phenotypes related to Acute Orbital Inflammation:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.61 BIN1 CRP HCK IL1RN KIDINS220 LTA
2 mortality/aging MP:0010768 9.4 BIN1 HCK IL1RN IRF6 KIDINS220 LTA

Drugs & Therapeutics for Acute Orbital Inflammation

Search Clinical Trials , NIH Clinical Center for Acute Orbital Inflammation

Genetic Tests for Acute Orbital Inflammation

Anatomical Context for Acute Orbital Inflammation

MalaCards organs/tissues related to Acute Orbital Inflammation:

42
Eye

Publications for Acute Orbital Inflammation

Articles related to Acute Orbital Inflammation:

# Title Authors Year
1
Case Series: Herpes Zoster Ophthalmicus with Acute Orbital Inflammation. ( 29554007 )
2018

Variations for Acute Orbital Inflammation

Expression for Acute Orbital Inflammation

Search GEO for disease gene expression data for Acute Orbital Inflammation.

Pathways for Acute Orbital Inflammation

Pathways related to Acute Orbital Inflammation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.54 HCK IL1RN IRF6 NCAM1 TPT1

GO Terms for Acute Orbital Inflammation

Biological processes related to Acute Orbital Inflammation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.62 CRP HCK IL1RN SDC1
2 lymph node development GO:0048535 9.26 LTA PDPN
3 negative regulation by host of viral transcription GO:0043922 9.16 HMGA2 POU2F3
4 interferon-gamma-mediated signaling pathway GO:0060333 9.13 HCK IRF6 NCAM1
5 negative regulation of apoptotic process GO:0043066 9.02 HCK HMGA2 OPA1 PDPN TPT1

Sources for Acute Orbital Inflammation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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