MCID: ACT077
MIFTS: 25

Acute Orbital Inflammation

Categories: Eye diseases

Aliases & Classifications for Acute Orbital Inflammation

MalaCards integrated aliases for Acute Orbital Inflammation:

Name: Acute Orbital Inflammation 12 15
Acute Inflammation of Orbit 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11230
ICD10 33 H05.0 H05.00
ICD9CM 35 376.0 376.00
SNOMED-CT 68 20551005
UMLS 73 C0155256

Summaries for Acute Orbital Inflammation

MalaCards based summary : Acute Orbital Inflammation, also known as acute inflammation of orbit, is related to orbital cellulitis and orbital periostitis. An important gene associated with Acute Orbital Inflammation is RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1), and among its related pathways/superpathways is NF-kappaB Signaling. Affiliated tissues include bone, eye and bone marrow, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Acute Orbital Inflammation

Diseases in the Acute Orbital Inflammation family:

Chronic Orbital Inflammation

Diseases related to Acute Orbital Inflammation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 orbital cellulitis 29.0 BIN1 COX5A CRP HCK IL1RN IRF6
2 orbital periostitis 11.2
3 orbital osteomyelitis 11.2
4 orbital tenonitis 11.2
5 intracranial sinus thrombosis 10.3 PGBD1 RHNO1
6 mastoiditis 10.3 CRP RHNO1
7 granulomatous orchitis 10.2 CRP PTCRA
8 orbital disease 10.2 CRP PGBD1 RHNO1
9 sphenoid sinusitis 10.2 CRP NT5C2 RHNO1
10 dental abscess 10.2 BIN1 CRP
11 cryopyrin-associated periodic syndrome 10.2 CRP IL1RN
12 pleural empyema 10.2 CRP PGBD1
13 acquired idiopathic sideroblastic anemia 10.2 COX5A TET2
14 hyper-igd syndrome 10.2 CRP IL1RN
15 myelodysplastic syndrome with excess blasts 10.2 LTA TET2
16 folic acid deficiency anemia 10.2 CRP TET2
17 schnitzler syndrome 10.2 CRP IL1RN
18 listeria meningitis 10.2 LTA RHNO1
19 acute cholangitis 10.2 CRP IL1RN NT5C2
20 ethmoid sinusitis 10.1 CRP RHNO1
21 chondromalacia 10.1 IL1RN TET2
22 spondylitis 10.1 CRP IL1RN LTA
23 pulmonary hemosiderosis 10.1 CRP HMGA2 TET2
24 juvenile rheumatoid arthritis 10.1 CRP IL1RN LTA
25 cartilage disease 10.1 CRP IL1RN TET2
26 chronic maxillary sinusitis 10.1 IRF6 PDPN RHNO1
27 intracranial abscess 10.0 BIN1 CRP ERAS
28 cecal disease 10.0 CRP HCK
29 gnathomiasis 9.9 PTCRA TET2
30 juvenile glaucoma 9.9 OPTN PTCRA SDC1
31 solitary osseous plasmacytoma 9.9 PTCRA SDC1
32 miliaria 9.9 PDPN SDC1
33 cavernous sinus thrombosis 9.9 PGBD1 PTCRA RHNO1 SDC1
34 bone marrow cancer 9.8 HMGA2 SDC1 TET2
35 herpes zoster 9.8
36 herpes zoster ophthalmicus 9.8

Graphical network of the top 20 diseases related to Acute Orbital Inflammation:



Diseases related to Acute Orbital Inflammation

Symptoms & Phenotypes for Acute Orbital Inflammation

GenomeRNAi Phenotypes related to Acute Orbital Inflammation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.1 SDC1
2 Decreased viability GR00221-A-1 10.1 HCK
3 Decreased viability GR00221-A-2 10.1 HCK
4 Decreased viability GR00221-A-4 10.1 HCK
5 Decreased viability GR00240-S-1 10.1 NT5C2 PDPN
6 Decreased viability GR00381-A-1 10.1 PTCRA SDC1
7 Decreased viability GR00402-S-2 10.1 BIN1 COX5A CRP ERAS HCK HMGA2
8 no effect GR00402-S-1 9.62 BIN1 COX5A CRP ERAS HCK HMGA2

MGI Mouse Phenotypes related to Acute Orbital Inflammation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.32 BIN1 CRP HCK IL1RN LTA OPTN

Drugs & Therapeutics for Acute Orbital Inflammation

Search Clinical Trials , NIH Clinical Center for Acute Orbital Inflammation

Genetic Tests for Acute Orbital Inflammation

Anatomical Context for Acute Orbital Inflammation

MalaCards organs/tissues related to Acute Orbital Inflammation:

41
Bone, Eye, Bone Marrow

Publications for Acute Orbital Inflammation

Articles related to Acute Orbital Inflammation:

# Title Authors Year
1
Case Series: Herpes Zoster Ophthalmicus with Acute Orbital Inflammation. ( 29554007 )
2018

Variations for Acute Orbital Inflammation

Expression for Acute Orbital Inflammation

Search GEO for disease gene expression data for Acute Orbital Inflammation.

Pathways for Acute Orbital Inflammation

Pathways related to Acute Orbital Inflammation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 HCK IL1RN IRF6 TPT1

GO Terms for Acute Orbital Inflammation

Biological processes related to Acute Orbital Inflammation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.56 CRP HCK IL1RN SDC1
2 negative regulation of apoptotic process GO:0043066 9.35 HCK HMGA2 IL1RN PDPN TPT1
3 lymph node development GO:0048535 9.16 LTA PDPN
4 negative regulation by host of viral transcription GO:0043922 8.62 HMGA2 POU2F3

Molecular functions related to Acute Orbital Inflammation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 BIN1 COX5A CRP HCK HMGA2 IL1RN

Sources for Acute Orbital Inflammation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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