MCID: ACT027
MIFTS: 59

Acute Pancreatitis

Categories: Bone diseases, Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Infectious diseases, Rare diseases
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Aliases & Classifications for Acute Pancreatitis

MalaCards integrated aliases for Acute Pancreatitis:

Name: Acute Pancreatitis 11 75 28 53 5 14 63 16 71 31 33
Pancreatitis, Acute Necrotizing 71
Acute Pancreas Inflammation 33
Pancreatitis Nos 33
Pancreatitis 43

Classifications:



External Ids:

Disease Ontology 11 DOID:2913
ICD9CM 34 577.0
MeSH 43 D010195
NCIt 49 C95437
SNOMED-CT 68 39726008
ICD10 31 K85 K85.9
UMLS 71 C0001339 C0267941

Summaries for Acute Pancreatitis

PubMed Health : 63 Acute pancreatitis: Acute pancreatitis is an inflammation of the pancreas that typically causes very sudden and very severe stomach ache. The most common causes are gallstones and excessive alcohol consumption. Acute pancreatitis can have serious complications, so it is typically treated in the hospital. Most of the time it passes without any serious problems developing in about one to two weeks. But in more severe cases of pancreatitis, treating the complications may take up to several months. Complications of pancreatitis can be fatal.

MalaCards based summary: Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to pancreatitis, hereditary and igg4-related disease. An important gene associated with Acute Pancreatitis is CPB1 (Carboxypeptidase B1), and among its related pathways/superpathways are Sudden infant death syndrome (SIDS) susceptibility pathways and CCL18 signaling pathway. The drugs Chlorhexidine and Cefoperazone have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and liver, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Disease Ontology: 11 A pancreatitis that is characterized by inflammation of the pancreas over a short period of time and has symptoms of severe abdominal pain, nausea, vomiting, diarrhea, fever, and shock.

Wikipedia: 75 Acute pancreatitis (AP) is a sudden inflammation of the pancreas. Causes in order of frequency include:... more...

Related Diseases for Acute Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Autoimmune Pancreatitis
Acute Pancreatitis Prss1-Related Hereditary Pancreatitis
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1954)
# Related Disease Score Top Affiliating Genes
1 pancreatitis, hereditary 32.6 SPINK1 SCT CCK
2 igg4-related disease 32.4 MPO IL10 CRP
3 mikulicz disease 32.2 SPINK1 IL10 CRP
4 hyperlipoproteinemia, type i 32.2 PNLIP LPL APOC2
5 adult respiratory distress syndrome 31.9 MPO IL6 IL10 ELANE CXCL8 CRP
6 alcohol use disorder 31.9 IL6 GPT CRP
7 hyperlipoproteinemia, type iv 31.9 LPL APOC2
8 ileus 31.7 IL6 IL10 CRP
9 compartment syndrome 31.7 IL6 GPT CRP
10 nutritional deficiency disease 31.7 SCT IL6 CRP CCK
11 cholelithiasis 31.7 SST GPT CRP CCK
12 cholecystitis 31.6 GPT CRP CCK
13 toxic shock syndrome 31.6 IL6 IL10 CXCL8 CRP
14 acute kidney failure 31.6 IL6 IL18 GPT
15 covid-19 31.5 IL6 IL10 CXCL8 CRP
16 alcoholic pancreatitis 31.5 SPINK1 SCT LPL CPB1 CCK
17 purpura 31.5 IL6 IL10 CXCL8 CRP
18 henoch-schoenlein purpura 31.5 MPO IL6 CRP
19 acute necrotizing pancreatitis 31.5 TMPRSS15 SST PNLIP MPO IL6 IL10
20 cholangitis 31.4 SST MPO IL6 IL10 GPT CXCL8
21 choledocholithiasis 31.4 GPT CRP CCK
22 respiratory failure 31.4 MPO IL6 IL18 IL10 GPT ELANE
23 pancreatitis 31.4 VMP1 TMPRSS15 SST SPINK1 SCT REG3A
24 ulcerative colitis 31.4 MPO IL6 IL10 CXCL8 CRP
25 obstructive jaundice 31.4 SST GPT CRP CCK
26 crohn's disease 31.3 IL6 IL18 IL10 CXCL8 CRP
27 disseminated intravascular coagulation 31.3 IL6 IL10 GPT ELANE CRP
28 acute cholangitis 31.3 IL6 GPT CRP
29 peritonitis 31.3 MPO IL6 IL18 IL10 ELANE CXCL8
30 pulmonary edema 31.3 IL10 CXCL8 CRP
31 mumps 31.3 IL6 IL10 CXCL8
32 hyperglycemia 31.3 SST LPL IL6 CCK
33 viral hepatitis 31.3 MPO IL6 GPT CRP
34 colitis 31.3 MPO IL6 IL18 IL10 CXCL8 CRP
35 paralytic ileus 31.3 IL6 GPT CRP
36 pain agnosia 31.3 IL6 IL10 CRP CCK
37 viral infectious disease 31.2 IL6 IL18 IL10 GPT CXCL8
38 leptin deficiency or dysfunction 31.2 LPL IL6 IL10 CRP CCK
39 appendicitis 31.2 MPO IL6 IL10 CXCL8 CRP
40 type 1 diabetes mellitus 31.2 SST LPL IL6 IL18 IL10 CXCL8
41 gastroenteritis 31.2 IL6 IL10 CXCL8 CRP
42 intestinal obstruction 31.2 IL6 GPT CRP
43 severe acute respiratory syndrome 31.2 IL6 IL10 GPT CXCL8 CTSB CRP
44 chickenpox 31.1 IL6 IL10 GPT CRP
45 splenic infarction 31.1 MPO GPT CRP
46 gallbladder disease 31.1 SST IL6 GPT CRP CCK
47 autoimmune pancreatitis 31.1 SPINK1 SCT IL10 CRP
48 dengue disease 31.1 IL6 IL10 GPT CXCL8
49 vasculitis 31.1 MPO IL6 IL10 ELANE CXCL8 CRP
50 aortic aneurysm 31.0 IL6 IL10 ELANE CXCL8 CRP

Comorbidity relations with Acute Pancreatitis via Phenotypic Disease Network (PDN): (show all 36)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Alcohol Use Disorder Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Atrophic Gastritis Biliary Tract Disease
Cholangitis Cholecystitis
Cholestasis Chronic Kidney Disease
Deficiency Anemia Duodenitis
Esophageal Disease Esophagitis
Gallbladder Disease Heart Disease
Hepatitis Hyperlipoproteinemia, Type Iv
Hypertension, Essential Hypothyroidism
Intestinal Obstruction Iron Deficiency Anemia
Irritable Bowel Syndrome Liver Disease
Pancreatic Agenesis 1 Pancreatic Cancer
Pancreatitis, Hereditary Paralytic Ileus
Postcholecystectomy Syndrome Protein-Energy Malnutrition
Respiratory Failure Strawberry Gallbladder

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to Acute Pancreatitis

Symptoms & Phenotypes for Acute Pancreatitis

GenomeRNAi Phenotypes related to Acute Pancreatitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 APOC2 CCK CPB1 CRP CTSB CXCL8
2 no effect GR00402-S-2 10.18 APOC2 CCK CPB1 CRP CTSB ELANE

MGI Mouse Phenotypes related to Acute Pancreatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 APOC2 CCK CPB1 CRP CTSB ELANE
2 digestive/alimentary MP:0005381 9.23 CTSB IL10 IL18 IL6 PNLIP SPINK1

Drugs & Therapeutics for Acute Pancreatitis

PubMed Health treatment related to Acute Pancreatitis: 63

No treatment is available for dealing with the root cause of pancreatitis . But there are a number of options for reducing strain on the pancreas and relieving symptoms. Because fluid levels can drop due to acute pancreatitis , the first step is to prevent dehydration by using infusion therapy . A hollow needle inserted in an arm vein is used to release a solution into the bloodstream. Medication is used to provide relief from pain, nausea and vomiting . Stronger painkillers such as opioids are sometimes needed, and they may make you feel drowsy or light-headed. Solid foods are avoided until the pain recedes and appetite returns to give the pancreas a chance to recuperate. In mild cases of pancreatitis it is sometimes possible to return to eating solid foods after just a few days. If the symptoms last longer, artificial feeding may be necessary to supply your body with enough nutrients . If the pancreatitis is caused by gallstones , the stones may need to be removed using endoscopic retrograde cholangiography. After treatment the gallbladder is surgically removed to prevent further episodes.

Drugs for Acute Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 344)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 4 55-56-1 2713 9552079
2
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185 44187
3
Acetylcysteine Approved, Investigational Phase 4 616-91-1 581 12035
4
Meropenem Approved, Investigational Phase 4 119478-56-7, 96036-03-2 441130
5
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
6
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415
7
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
8
Glycerin Approved, Investigational Phase 4 56-81-5 753
9
Dexmedetomidine Approved, Experimental, Vet_approved Phase 4 86347-14-0, 113775-47-6 68602 5311068
10
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
11
Meperidine Approved Phase 4 57-42-1 4058
12
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
13
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
14
Etomidate Approved Phase 4 33125-97-2 667484
15
Protein C Approved Phase 4
16
Etanercept Approved, Investigational Phase 4 185243-69-0
17
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
18
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
19
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 4 67-97-0, 1406-16-2 5280795 10883523
20
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
21
Resveratrol Investigational Phase 4 501-36-0 445154
22
Polygeline Experimental Phase 4 66455-30-9
23
Thymalfasin Investigational Phase 4 62304-98-7 16167214 16130571
24 Platelet Aggregation Inhibitors Phase 4
25 Antioxidants Phase 4
26 Disinfectants Phase 4
27 Sulperazone Phase 4
28 Chlorhexidine gluconate Phase 4
29 Parenteral Nutrition Solutions Phase 4
30 Fat Emulsions, Intravenous Phase 4
31 Soybean oil, phospholipid emulsion Phase 4
32 Respiratory System Agents Phase 4
33 Cyclooxygenase 2 Inhibitors Phase 4
34 Antiviral Agents Phase 4
35 Expectorants Phase 4
36 Antidotes Phase 4
37 N-monoacetylcystine Phase 4
38 Protective Agents Phase 4
39 Anesthetics, Intravenous Phase 4
40 Anesthetics, General Phase 4
41 Analgesics, Opioid Phase 4
42 Narcotics Phase 4
43 Anti-Bacterial Agents Phase 4
44 Hormones Phase 4
45 Anti-Infective Agents Phase 4
46 Hormone Antagonists Phase 4
47 Anticoagulants Phase 4
48 Fibrinolytic Agents Phase 4
49 Drotrecogin alfa activated Phase 4
50
Sitagliptin Phosphate Phase 4 654671-77-9

Interventional clinical trials:

(show top 50) (show all 612)
# Name Status NCT ID Phase Drugs
1 Escalade or Deseacalade Antibiotic Use in Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
2 The Use of Intravenous Ketorolac in a Multimodal Approach to Pain Management in Acute Pancreatitis Unknown status NCT04282200 Phase 4 Ketorolac
3 Comparative Study About the Impact of Two Oil Emulsions, One of Them Formulated With MCT, LCT, Olive Oil and Omega 3 Fatty Acids Versus Another One Formulated With MCT and LCT, Administered Intravenously on Severe Acute Pancreatitis Clinical Evolution Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
4 Randomized, Controlled, Open-label Trial of Intravenous Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis. Unknown status NCT03501680 Phase 4 Insulin
5 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
6 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Unknown status NCT02691598 Phase 4 Infusion
7 Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy for Periampullary Tumors: a Prospective, Randomized, Controlled Clinical Trial Unknown status NCT01642875 Phase 4
8 Effect Observation Study of COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis Unknown status NCT02964403 Phase 4 Cox-2;Indomethacin
9 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study. Unknown status NCT03082469 Phase 4
10 Randomized, Controlled, Multicenter Studies of the Effects of Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis Unknown status NCT03342807 Phase 4 Insulin
11 Comparative Evaluation of Standard Prophylaxis Versus Divided-dose NSAIDs or Hybrid NSAID and N-acetylcysteine Therapy for the Prevention of Post-ERCP Pancreatitis Unknown status NCT03708458 Phase 4 indomethacin suppository;N-acetylcysteine (NAC)
12 Oral Resveratrol Before ERCP Redused Overall Pancreatitis in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Multi-center, Single-blinded, Randomized Controlled Trial Unknown status NCT02947932 Phase 4 Resveratrol;Indomethacin
13 Randomized Controlled Trial on Sterile Fluid Collections Management in Acute Pancreatitis Completed NCT00786929 Phase 4 Conservative treatment
14 Enteral Nutrition for Treatment of Acute Pancreatitis - a Prospective, Randomized Clinical Trial Completed NCT01965873 Phase 4
15 APCAP - Activated Protein C in Severe Acute Pancreatitis: A Double-blind Randomized Human Pilot Trial Completed NCT01017107 Phase 4 Activated protein C
16 The Impact of Early Enteral Nutrition on the Clinical Outcomes of Severe Acute Pancreatitis Patients: A Randomized Control Trial Completed NCT00995098 Phase 4
17 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
18 Imipenem Prophylaxis of Infectious Complications in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
19 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
20 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
21 A Prospective Randomised Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
22 Thymosin Alpha 1 in the Prevention of Pancreatic Infection Following Acute Necrotizing Pancreatitis Completed NCT02473406 Phase 4 Thymosin Alpha 1;normal saline
23 A Multicentre, Randomised, Double-blind, Placebo-controlled, Study on the Use of Prophylactic Meropenem Therapy in Subjects With Severe Acute Necrotizing Pancreatitis Completed NCT00061438 Phase 4 meropenem
24 A Prospective Study of Celiac Block Technique: One Injection or Two? Completed NCT00583479 Phase 4
25 Double-blind Randomized Study to Determine the Efficacy of Intramuscular Vitamin D3 Supplementation in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
26 Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis Completed NCT00957151 Phase 4 Creon
27 Enzyme Substitution in Exocrine Pancreatic Insufficiency; Self Administration Against a Fixed Dose Regimen Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
28 A Multi-Center, Prospective, Randomized Study Comparing Removable, Self-Expanding Metal Stents to Plastic Stents for the Treatment of Benign Biliary Strictures Secondary to Chronic Pancreatitis Completed NCT01543256 Phase 4
29 Rectally Administered Indomethacin to Prevent Post-ESWL-pancreatitis (RIPEP) Completed NCT02797067 Phase 4 indomethacin suppository;Glycerin Suppository
30 Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis Completed NCT00318994 Phase 4 Meropenem
31 Diclophenac Potassium Versus Ceftazidime for Reduction of Post ERCP Pancreatitis in Average Risk Patients-double Blind, Randomised Controlled Trial Completed NCT01784445 Phase 4 Ceftazidime
32 Etomidate With Meperidine vs Midazolam With Meperidine for Sedation During Endodscopic Retrograde Cholangiopancreatogram (ERCP) Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
33 Dexmedetomidine vs Placebo in ERCP Sedation.A Randomized Pilot Study Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
34 Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube Completed NCT00999232 Phase 4 Erythromycin;Placebo
35 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Randomized Multi-center Study Completed NCT01744847 Phase 4
36 A Double-Blind, Randomized, Placebo Controlled Intervention Study to Assess the Impact of Sitagliptin 100 mg/Day for 1 Year on Insulin Independence Following Pancreatectomy and Autoislet Transplantation Completed NCT01186562 Phase 4 Sitagliptin;Placebo
37 Treatment With Balanced Crystalloid Solutions in the Early Phase of Acute Pancreatitis Recruiting NCT04688645 Phase 4 Balanced crystalloid solution;Normal saline
38 A Phase 4 Study to Assess Symptoms of Exocrine Pancreatic Insufficiency in Subjects With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon® (Pancrelipase) With an Alternate Source of Active Pharmaceutical Ingredient Recruiting NCT05069597 Phase 4 CREON
39 Anti-inflammatory Therapy to Improve Outcomes in Patients With Chronic Pancreatitis Undergoing Total Pancreatectomy Islet Autotransplantation Active, not recruiting NCT02713997 Phase 4 etanercept;Alpha 1-Antitrypsin
40 Comparison of Insulin and Standard Management in Hypertriglyceridemic Acute Pancreatitis in Patients Without Diabetes Not yet recruiting NCT05487833 Phase 4
41 Multicenter, Double-bind, Randomised, Placebo Controlled Study of Ulinastatin in Severe Acute Pancreatitis Suspended NCT01132521 Phase 4 ulinastatin;placebo
42 Treatment of Acute Pancreatitis With Ketorolac Terminated NCT02885441 Phase 4 Ketorolac
43 Intraduodenal Aspiration Study to Assess the Bioavailability of Oral Pancrecarb® Compared to Placebo Control in Patients With Pancreatic Insufficiency Terminated NCT00744250 Phase 4 Pancrelipase
44 A Prospective, Randomized, Controlled Trial of Rectal Indomethacin in the Prevention of Post-ERCP Pancreatitis in High Risk Patients. Terminated NCT00820612 Phase 4 Indomethacin
45 Diclofenac for the Prevention of Post-ERCP Pancreatitis in Higher Risk Patients: A Prospective, Randomized, Double Blind, Placebo Controlled Trial. Terminated NCT00428025 Phase 4 diclofenac;placebo
46 A Phase 4 Open-Label Single-Arm Study To Evaluate The Use Of CREON In Subjects With EPI Due To Etiologies Other Than Cystic Fibrosis, Chronic Pancreatitis, Pancreatectomy, Or Pancreatic Cancer Withdrawn NCT04315311 Phase 4 CREON
47 Thiopurine Induced Pancreatitis in IBD Patients Withdrawn NCT02281799 Phase 4 Azathioprine
48 A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis Withdrawn NCT02465138 Phase 4 Ketorolac;Placebo
49 Epidural Anesthesia as an Alternative for Management in Acute Pancreatitis, a Randomised Clinical Trial Unknown status NCT02617199 Phase 2, Phase 3 Epidural anesthesia;intravenous analgesia
50 Randomized Trial of Standard vs. Enhanced Hydration in Patients With a Diagnosis of Acute Pancreatitis Within the First Hour of the Diagnosis Unknown status NCT02709044 Phase 2, Phase 3 Ringer lactate

Search NIH Clinical Center for Acute Pancreatitis

Cochrane evidence based reviews: pancreatitis

Genetic Tests for Acute Pancreatitis

Genetic tests related to Acute Pancreatitis:

# Genetic test Affiliating Genes
1 Acute Pancreatitis 28

Anatomical Context for Acute Pancreatitis

Organs/tissues related to Acute Pancreatitis:

MalaCards : Pancreas, Bone Marrow, Liver, Pancreatic Islet, Lung, Spinal Cord, Colon

Publications for Acute Pancreatitis

Articles related to Acute Pancreatitis:

(show top 50) (show all 26510)
# Title Authors PMID Year
1
Obesity and the risk of severe acute pancreatitis. 53 62
20485254 2010
2
Different profiles of cytokine expression during mild and severe acute pancreatitis. 53 62
20397261 2010
3
Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype. 53 62
20110462 2010
4
-651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan. 53 62
19997857 2010
5
Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis. 53 62
19844201 2010
6
New diagnostic criteria of acute pancreatitis. 53 62
20012328 2010
7
[Effect of qingyi decoction in treating severe acute pancreatitis and its impacts on blood level of tumor necrosis factor-alpha, interleukin-6 and inteleukin-8]. 53 62
20214338 2009
8
Alipogene tiparvovec, an adeno-associated virus encoding the Ser(447)X variant of the human lipoprotein lipase gene for the treatment of patients with lipoprotein lipase deficiency. 53 62
20072945 2009
9
Pathogenic role of myeloperoxidase in acute pancreatitis. 53 62
20007081 2009
10
[Influence of integrated traditional Chinese and Western medicine therapy on serum resistin levels in patients with severe acute pancreatitis: a randomized controlled trial]. 53 62
20015433 2009
11
Simultaneous proteosome inhibition and heat shock protein induction by bortezomib is beneficial in experimental pancreatitis. 53 62
19486901 2009
12
Role of pancreatitis-associated protein 1 on oxidative stress-induced cell death of pancreatic acinar cells. 53 62
19723102 2009
13
Efficacy of recombinant human interleukin-10 in prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis in subjects with increased risk. 53 62
19214137 2009
14
Can wire-guided cannulation prevent post-ERCP pancreatitis? A prospective randomized trial. 53 62
19007927 2009
15
A combined in vitro and in vivo study on the interactions between somatostatin and lipid-based liquid crystalline drug carriers and bilayers. 53 62
19041716 2009
16
Microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene is associated with susceptibility to acute pancreatitis in Japan. 53 62
19280717 2009
17
Pancreatitis-associated protein is related closely to neoplastic proliferative activity in patients with colorectal carcinoma. 53 62
19051257 2009
18
[The study of the relationship between interleukin gene polymorphism and the morbidity of patients with acute pancreatitis]. 53 62
19220961 2009
19
Icam-1 and acute pancreatitis complicated by acute lung injury. 53 62
19129609 2009
20
Acute pancreatitis in a girl with panhypopituitarism due to craniopharyngioma on growth hormone treatment. A combination of risk factors. 53 62
19506396 2009
21
Acute pancreatitis as a model of SIRS. 53 62
19273184 2009
22
Diagnostic accuracy of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: a meta-analysis. 53 62
20110745 2009
23
Serum profiles of C-reactive protein, interleukin-8, and tumor necrosis factor-alpha in patients with acute pancreatitis. 53 62
20130823 2009
24
Activated protein C-protein C inhibitor complex, activation peptide of carboxypeptidase B and C-reactive protein as predictors of severe acute pancreatitis. 53 62
19684435 2009
25
Significance of endothelial molecular markers in the evaluation of the severity of acute pancreatitis. 53 62
19319639 2009
26
[Interleukin 18 (IL-18) and other immunological parameters as markers of severity in acute pancreatitis]. 53 62
19222336 2008
27
[Relationship between acute pancreatitis and systemic inflammation response syndrome in children]. 53 62
19102837 2008
28
Effect of somatostatin in the prevention of pancreatic complications after endoscopic retrograde cholangiopancreatography. 53 62
19114324 2008
29
Implication of interleukin 18 and intercellular adhesion molecule (ICAM)-1 in acute pancreatitis. 53 62
19102398 2008
30
Molecular basis for pancreatitis. 53 62
19122498 2008
31
The SPINK1 N34S variant is associated with acute pancreatitis. 53 62
18617776 2008
32
Therapy for acute pancreatitis with platelet-activating factor receptor antagonists. 53 62
18720532 2008
33
Pancreatitis-associated protein 2 modulates inflammatory responses in macrophages. 53 62
18641332 2008
34
The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats. 53 62
18486906 2008
35
Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice. 53 62
18515422 2008
36
[Acute pancreatitis secondary to hypertriglyceridemia - a report of two cases]. 53 62
18752369 2008
37
Ritonavir and disulfiram may be synergistic in lowering active interleukin-18 levels in acute pancreatitis, and thereby hasten recovery. 53 62
18469453 2008
38
[Utility of endoscopic ultrasonography in the etiological diagnosis of patients with acute idiopathic pancreatitis]. 53 62
18405484 2008
39
Acute pancreatitis. 53 62
18388680 2008
40
Is there correlation between pancreatic enzyme and radiological severity in acute pancreatitis? 53 62
18416469 2008
41
Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. 53 62
18160487 2008
42
TLR and MBL gene polymorphisms in severe acute pancreatitis. 53 62
18288881 2008
43
Protease activation, pancreatic leakage, and inflammation in acute pancreatitis: differences between mild and severe cases and changes over the first three days. 53 62
18849642 2008
44
Monocyte chemoattractant protein 1, active carboxypeptidase B and CAPAP at hospital admission are predictive markers for severe acute pancreatitis. 53 62
18235216 2008
45
[Pancreatitis in pregnant women]. 53 62
18720707 2008
46
Risk factors for recurrent acute alcohol-associated pancreatitis: a prospective analysis. 53 62
18415757 2008
47
Sphincter of Oddi dysfunction and pancreatitis. 53 62
18081221 2007
48
A novel complex deletion-insertion mutation mediated by Alu repetitive elements leads to lipoprotein lipase deficiency. 53 62
17706445 2007
49
Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis. 53 62
17907957 2007
50
Alterations of Toll-like receptor 4 expression on peripheral blood monocytes during the early stage of human acute pancreatitis. 53 62
17415654 2007

Variations for Acute Pancreatitis

Expression for Acute Pancreatitis

Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for Acute Pancreatitis

GO Terms for Acute Pancreatitis

Cellular components related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.16 APOC2 CCK CPB1 CRP CTSB CXCL8
2 extracellular space GO:0005615 9.85 APOC2 CCK CPB1 CRP CTSB CXCL8

Biological processes related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of chemokine production GO:0032722 9.8 LPL IL6 IL18
2 acute-phase response GO:0006953 9.73 REG3A IL6 CRP
3 triglyceride homeostasis GO:0070328 9.63 LPL IL18 APOC2
4 positive regulation of pancreatic juice secretion GO:0090187 9.26 SPINK1 SCT
5 chylomicron remodeling GO:0034371 8.92 LPL APOC2

Sources for Acute Pancreatitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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