MCID: ACT027
MIFTS: 59

Acute Pancreatitis

Categories: Bone diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Pancreatitis

MalaCards integrated aliases for Acute Pancreatitis:

Name: Acute Pancreatitis 12 77 38 30 56 6 15 17 74 64
Pancreatitis, Acute Necrotizing 74
Acute Necrotizing Pancreatitis 12
Pancreatitis Necrotizing 12
Necrotizing Pancreatitis 56

Classifications:



External Ids:

Disease Ontology 12 DOID:2913
KEGG 38 H01681
ICD9CM 36 577.0
NCIt 51 C95437
SNOMED-CT 69 39726008
ICD10 34 K85 K85.9

Summaries for Acute Pancreatitis

PubMed Health : 64 About acute pancreatitis: Acute pancreatitis is an inflammation of the pancreas that typically causes very sudden and very severe stomach ache. The most common causes are gallstones and excessive alcohol consumption.Acute pancreatitis can have serious complications, so it is typically treated in the hospital. Most of the time it passes without any serious problems developing in about one to two weeks. But in more severe cases of pancreatitis, treating the complications may take up to several months. Complications of pancreatitis can be fatal.

MalaCards based summary : Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to recurrent acute pancreatitis and acute respiratory distress syndrome. An important gene associated with Acute Pancreatitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Amoebiasis. The drugs Nefopam and Ropivacaine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Acute pancreatitis is a sudden inflammation of the pancreas. Causes in order of frequency include a... more...

Related Diseases for Acute Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Autoimmune Pancreatitis
Acute Pancreatitis Prss1-Related Hereditary Pancreatitis
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 620)
# Related Disease Score Top Affiliating Genes
1 recurrent acute pancreatitis 34.0 LPL SCT SPINK1
2 acute respiratory distress syndrome 31.1 CXCL8 ELANE IL6
3 cholangitis 30.7 CRP GPT IL6
4 obstructive jaundice 30.6 CRP CXCL8 GPT IL6
5 colitis 30.6 CXCL8 IL10 IL6 MPO
6 hemorrhagic fever 30.6 GPT IL10 IL6
7 gastroenteritis 30.5 CRP CXCL8 IL10 IL6
8 dengue hemorrhagic fever 30.4 CXCL8 IL10 IL6
9 leptospirosis 30.4 CRP CXCL8 IL10 IL6
10 brucellosis 30.4 CRP CXCL8 IL10 IL6
11 pancreatitis 30.4 APOC2 CCK CPB1 CRP CTSB LPL
12 hemorrhagic fever with renal syndrome 30.4 CRP CXCL8 IL6
13 cholelithiasis 30.4 CCK GPT SST
14 ulcerative colitis 30.3 CRP CXCL8 IL10 IL6 MPO
15 acute cholangitis 30.3 CRP IL6
16 inflammatory bowel disease 30.3 CRP CXCL8 IL10 IL6 MPO
17 respiratory failure 30.3 CRP CXCL8 ELANE
18 scrub typhus 30.2 CRP GPT IL10
19 meningitis 30.2 CRP CXCL8 IL10 IL6
20 polyarteritis nodosa 30.2 CRP IL6 MPO
21 acalculous cholecystitis 30.1 CCK CRP
22 peritonitis 30.1 CRP CXCL8 IL10 IL6 MPO
23 pyelonephritis 30.1 CRP CXCL8 IL10 IL6
24 peptic ulcer disease 30.0 CXCL8 IL10 SCT
25 pneumonia 30.0 CRP CXCL8 ELANE IL10 IL6 MPO
26 morbid obesity 30.0 CCK CRP LPL
27 adult respiratory distress syndrome 30.0 CXCL8 ELANE IL10 IL6
28 ischemic heart disease 30.0 CRP IL6 LPL
29 duodenal ulcer 30.0 CCK CXCL8 SCT SST
30 bacterial infectious disease 30.0 CRP CXCL8 ELANE IL10 IL6
31 cystitis 29.9 CRP CXCL8 IL6
32 streptococcal toxic-shock syndrome 29.9 CXCL8 IL6
33 vasculitis 29.9 CRP ELANE MPO
34 pulmonary edema 29.9 CRP CXCL8 IL10
35 osteomyelitis 29.9 CXCL8 IL10 IL6
36 sleep apnea 29.9 CRP CXCL8 IL6
37 toxic shock syndrome 29.9 CXCL8 IL10 IL6
38 appendicitis 29.9 CRP CXCL8 IL10 IL6 MPO
39 mouth disease 29.8 CRP IL10 IL6
40 paralytic ileus 29.8 CCK CRP
41 cystic fibrosis 29.8 CXCL8 ELANE MPO PNLIP REG3A SPINK1
42 kawasaki disease 29.8 CRP ELANE IL10 IL6
43 alcoholic hepatitis 29.7 CXCL8 GPT IL10 IL6
44 pancreatic agenesis 1 29.7 PNLIP SCT SPINK1
45 heart disease 29.6 CRP CXCL8 IL10 IL6 LPL
46 biliary dyskinesia 29.6 CCK SCT
47 body mass index quantitative trait locus 11 29.5 CCK CRP GPT IL6 LPL PNLIP
48 alcoholic pancreatitis 29.5 CCK LPL SCT SPINK1
49 exocrine pancreatic insufficiency 29.2 CCK PNLIP SCT SPINK1
50 diabetes mellitus, noninsulin-dependent 29.1 APOC2 CRP GPT IL6 LPL SST

Comorbidity relations with Acute Pancreatitis via Phenotypic Disease Network (PDN): (show all 38)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Alcohol Abuse Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Atrophic Gastritis Biliary Tract Disease
Cholangitis Cholecystitis
Cholestasis Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Duodenitis Esophageal Disease
Esophagitis Gallbladder Disease
Heart Disease Hepatitis
Hyperlipoproteinemia, Type Iv Hypertension, Essential
Hypothyroidism Intestinal Obstruction
Iron Deficiency Anemia Irritable Bowel Syndrome
Ischemic Heart Disease Liver Disease
Pancreatic Agenesis 1 Pancreatic Cancer
Pancreatitis, Hereditary Paralytic Ileus
Postcholecystectomy Syndrome Protein-Energy Malnutrition
Respiratory Failure Strawberry Gallbladder

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to Acute Pancreatitis

Symptoms & Phenotypes for Acute Pancreatitis

GenomeRNAi Phenotypes related to Acute Pancreatitis according to GeneCards Suite gene sharing:

27 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.78 CPB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.78 PLA2G6
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.78 SPINK1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.78 MPO
6 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.78 SPINK1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.78 MPO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.78 CPB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.78 PLA2G6
10 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.78 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.78 MPO
12 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.78 PLA2G6
13 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.78 SPINK1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.78 CPB1 MPO PLA2G6 SPINK1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.78 CPB1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.78 CPB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.78 MPO
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.78 CPB1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.78 MPO
20 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.78 PLA2G6
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.78 SPINK1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.78 MPO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.78 MPO
24 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.78 CPB1 PLA2G6
25 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 CPB1

MGI Mouse Phenotypes related to Acute Pancreatitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 APOC2 CCK CRP CTSB ELANE IL10

Drugs & Therapeutics for Acute Pancreatitis

PubMedHealth treatment related to Acute Pancreatitis: 64

No treatment is available for dealing with the root cause of pancreatitis. But there are a number of options for reducing strain on the pancreas and relieving symptoms. Because fluid levels can drop due to acute pancreatitis, the first step is to prevent dehydration by using infusion therapy. A hollow needle inserted in an arm vein is used to release a solution into the bloodstream. Medication is used to provide relief from pain, nausea and vomiting. Stronger painkillers such as opioids are sometimes needed, and they may make you feel drowsy or light-headed.Solid foods are avoided until the pain recedes and appetite returns to give the pancreas a chance to recuperate. In mild cases of pancreatitis it is sometimes possible to return to eating solid foods after just a few days. If the symptoms last longer, artificial feeding may be necessary to supply your body with enough nutrients.If the pancreatitis is caused by gallstones, the stones may need to be removed using endoscopic retrograde cholangiography. After treatment the gallbladder is surgically removed to prevent further episodes.

Drugs for Acute Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 272)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nefopam Approved, Investigational Phase 4 13669-70-0
2
Ropivacaine Approved Phase 4,Phase 2,Phase 3,Phase 1 84057-95-4 71273 175805
3
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
4
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 3 27203-92-5 33741
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Clonidine Approved Phase 4 4205-90-7 2803
7
Somatostatin Approved, Investigational Phase 4,Phase 3,Not Applicable 38916-34-6, 51110-01-1 53481605
8
Meropenem Approved, Investigational Phase 4,Phase 1,Phase 2 119478-56-7, 96036-03-2 441130 64778
9
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185
10
Metronidazole Approved Phase 4 443-48-1 4173
11
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
12
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
13
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
14
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53-86-1 3715
15
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
16
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
17
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 53608-75-6
18
Ketorolac Approved Phase 4,Phase 2,Phase 3 66635-83-4, 74103-06-3 3826
19
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
20
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415 5280454
21
Protein C Approved Phase 4
22
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
23
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
24
Glycerol Approved, Investigational Phase 4,Phase 3 56-81-5 753
25
Zinc Approved, Investigational Phase 4,Phase 3 7440-66-6 32051
26
Azathioprine Approved Phase 4 446-86-6 2265
27
Thioguanine Approved Phase 4 154-42-7 2723601
28
Mercaptopurine Approved Phase 4 50-44-2 667490
29
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Not Applicable 7440-70-2 271
30
Serine Approved, Nutraceutical Phase 4,Phase 1 56-45-1 5951
31 Parenteral Nutrition Solutions Phase 4
32 Fat Emulsions, Intravenous Phase 4
33 Olive Phase 4,Not Applicable
34 Soy Bean Phase 4
35 Soybean oil, phospholipid emulsion Phase 4
36 Omega 3 Fatty Acid Phase 4,Phase 2
37 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Anesthetics, General Phase 4,Phase 2,Phase 3,Phase 1
40 Adjuvants, Anesthesia Phase 4,Phase 2,Phase 3,Phase 1
41 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Antipyretics Phase 4
43 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Anesthetics, Intravenous Phase 4,Phase 2,Phase 3,Phase 1
45 Anesthetics, Local Phase 4,Phase 2,Phase 3,Not Applicable
46 Narcotics Phase 4,Phase 2,Phase 3,Phase 1
47 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Analgesics, Opioid Phase 4,Phase 2,Phase 3,Phase 1
50 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 249)
# Name Status NCT ID Phase Drugs
1 Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
2 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
3 Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
4 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
5 Oral Resveratrol to Prevent Post-ERCP Pancreatitis Unknown status NCT02947932 Phase 4 Resveratrol;Indomethacin
6 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis Unknown status NCT02691598 Phase 4 Infusion
7 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal Unknown status NCT03082469 Phase 4
8 COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis Unknown status NCT02964403 Phase 4 Cox-2;Indomethacin
9 Imipenem Prophylaxis in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
10 Activated Protein C in Severe Acute Pancreatitis Completed NCT01017107 Phase 4 Activated protein C
11 Enteral Nutrition in Acute Pancreatitis Completed NCT01965873 Phase 4
12 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
13 Acute Pancreatitis and Acute Fluid Collections Completed NCT00786929 Phase 4 Conservative treatment
14 Early Enteral Nutrition for Severe Acute Pancreatitis Completed NCT00995098 Phase 4
15 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
16 A Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
17 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
18 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
19 To Study the Effects of Lipid Emulsion on Hemodynamics in Organophosphate Compound Poisoning Completed NCT03564574 Phase 4
20 Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial Completed NCT02517476 Phase 4
21 A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died Completed NCT00061438 Phase 4 meropenem
22 Thiopurine Induced Pancreatitis in IBD Patients Recruiting NCT02281799 Phase 4 Azathioprine
23 Calcium Administration in Cardiac Surgery Recruiting NCT03772990 Phase 4 Calcium Chloride;0.9% Sodium Chloride
24 Rectal Indomethacin to Prevent Post ESWL-pancreatitis Recruiting NCT02797067 Phase 4 indomethacin suppository;Glycerin Suppository
25 Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis. Not yet recruiting NCT03501680 Phase 4 Insulin
26 Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis Not yet recruiting NCT03342807 Phase 4 Insulin
27 Ulinastatin in Severe Acute Pancreatitis Suspended NCT01132521 Phase 4 ulinastatin;placebo
28 Treatment of Acute Pancreatitis With Ketorolac Terminated NCT02885441 Phase 4 Ketorolac
29 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
30 Epidural Anesthesia in Acute Pancreatitis Unknown status NCT02617199 Phase 2, Phase 3 Epidural anesthesia;intravenous analgesia
31 Fluid Resuscitation in Acute Pancreatitis Unknown status NCT02709044 Phase 2, Phase 3 Ringer lactate
32 Evaluation of Effect of Integrated Treatment by Traditional Chinese and Western Medicine for Severe Acute Pancreatitis Unknown status NCT00506337 Phase 2, Phase 3 Qingyi granules
33 Efficacy of Administration of Somatostatin in the Prevention of Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis Unknown status NCT01060826 Phase 3 somatostatin, intravenous bolus;somatostatin
34 Effect of Traditional Chinese Medicine on GI Function Recovery and Nutrition Support in SAP Unknown status NCT00508729 Phase 2, Phase 3 Qingyi granules
35 Safety and Efficacy in LPL-Deficient Subjects of AMT-011, an Adeno-Associated Viral Vector Expressing Human Lipoprotein Lipase [S447X] Unknown status NCT01109498 Phase 2, Phase 3 Mycophenolate mofetil;cyclosporine
36 MIld to MOderate Acute Pancreatitis: Early naSogastric Tube Feeding Compared With pAncreas Rest (MIMOSA) Completed NCT01128478 Phase 2, Phase 3
37 Indomethacin Decreases Post-ERCP Pancreatitis Completed NCT02110810 Phase 3 Indomethacin;2.6-g suppository of glycerin
38 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
39 Trial of Aggressive Hydration Versus Rectal Indomethacin for Prevention of Post-ERCP Pancreatitis Completed NCT03629600 Phase 2, Phase 3 Lactated Ringer;Rectal Form Indometacin
40 Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis Completed NCT01977118 Phase 2, Phase 3 streptokinase
41 Lactated Ringers With or Without Rectal Indomethacin to Prevent Post-ERCP Pancreatitis Completed NCT02641561 Phase 3 Indomethacin;Lactated Ringer's Solution;Normal Saline;Placebo
42 Does Glyceryl Nitrate Prevent Post-Endoscopic Retrograde Cholangiopancreaticography (ERCP) Pancreatitis? Completed NCT00121901 Phase 3 glyceryl nitrate
43 Effects of Delayed Enteral Nutrition on Inflammatory Responses and Immune Function Competence in Critically Ill Patients With Prolonged Fasting Completed NCT01834430 Phase 3
44 Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis Completed NCT00523341 Phase 3
45 A Prospective Validation Study of Albumin Kinetics With Tracer 123 I-HSA Completed NCT01686776 Phase 3
46 A Study of Dulaglutide (LY2189265) in Participants With Type II Diabetes Completed NCT02152371 Phase 3 Dulaglutide;Placebo;Insulin Glargine;Metformin
47 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
48 A Study of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes Mellitus Completed NCT02597049 Phase 3 Dulaglutide;Placebo;SGLT2 inhibitor;Metformin
49 Study of How Dulaglutide Compares to Placebo in Participants With Type 2 Diabetes Who Are Also on Sulfonylurea Therapy (AWARD-8) Completed NCT01769378 Phase 3 Placebo;Dulaglutide;Glimepiride
50 A Study Comparing the Effect of Dulaglutide With Liraglutide in Type 2 Diabetes Completed NCT01624259 Phase 3 LY2189265;Liraglutide;Metformin

Search NIH Clinical Center for Acute Pancreatitis

Genetic Tests for Acute Pancreatitis

Genetic tests related to Acute Pancreatitis:

# Genetic test Affiliating Genes
1 Acute Pancreatitis 30

Anatomical Context for Acute Pancreatitis

MalaCards organs/tissues related to Acute Pancreatitis:

42
Pancreas, Lung, Liver, Neutrophil, Kidney, Testes, Monocytes

Publications for Acute Pancreatitis

Articles related to Acute Pancreatitis:

(show top 50) (show all 4384)
# Title Authors Year
1
Local hyperthyroidism promotes pancreatic acinar cell proliferation during acute pancreatitis. ( 30714146 )
2019
2
Fraxinellone inhibits inflammatory cell infiltration during acute pancreatitis by suppressing inflammasome activation. ( 30716587 )
2019
3
Inhibition of PAK1 alleviates cerulein-induced acute pancreatitis via p38 and NF-κB pathways. ( 30718368 )
2019
4
Clinical assessment and management of severe acute pancreatitis: a multi-disciplinary approach in the XXI century. ( 30720186 )
2019
5
Diabetic Ketoacidosis Revealing a Severe Hypertriglyceridemia and Acute Pancreatitis in Type 1 Diabetes Mellitus. ( 30723557 )
2019
6
Do Elevated Triglycerides Truly Trigger Acute Pancreatitis? ( 30725299 )
2019
7
Association between IL-10 polymorphisms rs1800896 and rs1800871 and risk of acute pancreatitis in Chinese Han population: An update systemic review and meta-analysis. ( 30729935 )
2019
8
How to deal with severe acute pancreatitis in the critically ill. ( 30730344 )
2019
9
Enhanced Neutrophil Extracellular Trap Formation in Acute Pancreatitis Contributes to Disease Severity and Is Reduced by Chloroquine. ( 30733719 )
2019
10
Neutrophil-to-lymphocyte ratio can specifically predict the severity of hypertriglyceridemia-induced acute pancreatitis compared with white blood cell. ( 30737845 )
2019
11
Heme oxygenase-1 induced by desoxo-narchinol-A attenuated the severity of acute pancreatitis via blockade of neutrophil infiltration. ( 30738992 )
2019
12
Effects of alpha-tocopherol on acute pancreatitis in rat. ( 30742296 )
2019
13
Bidirectional Effects of Pyrrolidine Dithiocarbamate on Severe Acute Pancreatitis in a Rat Model. ( 30745862 )
2019
14
Young Age Predicts Acute Pancreatitis Severity in Children. ( 30747814 )
2019
15
Role of Diagnostic Endoscopic Ultrasound in Idiopathic Acute Pancreatitis and Acute Recurrent Pancreatitis in Children. ( 30747822 )
2019
16
Serum Serine Peptidase Inhibitor Kazal-Type 1, Trypsinogens 1 to 3, and Complex of Trypsin 2 and α1-Antitrypsin in the Diagnosis of Severe Acute Pancreatitis. ( 30747826 )
2019
17
Inflammation-targeted Delivery of Celastrol via Neutrophil Membrane Coated Nanoparticles in the Management of Acute Pancreatitis. ( 30753778 )
2019
18
Quantification of the impact of interventional radiology in the management of acute pancreatitis. ( 30759306 )
2019
19
Effects of Tec Tyrosine Kinase Inhibition on the Inflammatory Response of Severe Acute Pancreatitis-Associated Acute Lung Injury in Mice. ( 30761473 )
2019
20
Evolution of Transluminal Necrosectomy for Acute Pancreatitis to Stent in Stent Therapy: Step-Up Approach Leads to Low Mortality and Morbidity Rates in 302 Consecutive Cases of Acute Pancreatitis. ( 30762470 )
2019
21
The triad of diabetes ketoacidosis, hypertriglyceridemia and acute pancreatitis. How does it affect mortality and morbidity?: A 10-year analysis of the National Inpatient Sample. ( 30762737 )
2019
22
Unusual presentation of acute pancreatitis following high tibial osteotomy. ( 30765443 )
2019
23
Acute Pancreatitis after Colonoscopy: A Case Presentation and Literature Review. ( 30766736 )
2019
24
Correlation of Serum and Ascitic Fluid Soluble Form Urokinase Plasminogen Activator Receptor Levels With Patient Complications, Disease Severity, Inflammatory Markers, and Prognosis in Patients With Severe Acute Pancreatitis. ( 30768571 )
2019
25
Blood Urea Nitrogen Elevation Is a Marker for Pediatric Severe Acute Pancreatitis. ( 30768572 )
2019
26
Organ Failure due to Systemic Injury in Acute Pancreatitis. ( 30768987 )
2019
27
Development and validation of a novel clinical scoring system for short-term prediction of death in dogs with acute pancreatitis. ( 30770578 )
2019
28
Association of total cholesterol with severe acute pancreatitis: A U-shaped relationship. ( 30772093 )
2019
29
Annals for Hospitalists Inpatient Notes - Clinical Pearls-Acute Pancreatitis. ( 30776825 )
2019
30
Effect of Sheng-jiang powder on multiple-organ inflammatory injury in acute pancreatitis in rats fed a high-fat diet. ( 30783372 )
2019
31
Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis. ( 30783376 )
2019
32
Vitamin D deficiency predicts severe acute pancreatitis. ( 30788120 )
2019
33
Percutaneous Drainage Versus Peritoneal Lavage for Pancreatic Ascites in Severe Acute Pancreatitis: A Prospective Randomized Trial. ( 30789387 )
2019
34
Acute pancreatitis in a patient with glycogen storage disease type 1a. ( 30792145 )
2019
35
Recurrent acute pancreatitis in a patient with both gallbladder and cystic duct agenesis and polycystic liver disease. ( 30792840 )
2019
36
Acute pancreatitis associated with intravenous administration of propofol: evaluation of causality in a systematic review of the literature. ( 30792862 )
2019
37
Classic chronic pancreatitis is associated with prior acute pancreatitis in only 50% of patients in a large single-institution study. ( 30795927 )
2019
38
The Prognostic Role of Peripheral Lymphocyte Subsets in Patients With Acute Pancreatitis. ( 30797505 )
2019
39
Visnagin attenuates acute pancreatitis via Nrf2/NFκB pathway and abrogates associated multiple organ dysfunction. ( 30798137 )
2019
40
"Endoscopic ultrasound first policy" in acute pancreatitis of presumed biliary origin. ( 30802429 )
2019
41
Nonalcoholic Fatty Liver Disease Aggravated the Severity of Acute Pancreatitis in Patients. ( 30805370 )
2019
42
The consensus of integrative diagnosis and treatment of acute pancreatitis-2017. ( 30806495 )
2019
43
Correction: Endoscopic Placement of a U-Shaped Plastic Stent in Patients With Recurrent Acute Pancreatitis and Incomplete Pancreas Divisum. ( 30807295 )
2019
44
Functional Abdominal Pain in a Pediatric Patient After Resolution of Acute Pancreatitis: A Case Report. ( 30807299 )
2019
45
Acute pancreatitis and acute kidney injury in dogs. ( 30819430 )
2019
46
The Relationship between Liver Injury and Serum Levels of C-Reactive Protein and Procalcitonin in Patients with Acute Pancreatitis. ( 30823962 )
2019
47
Hypercalcemia secondary to excessive self-medication with antacids causing acute pancreatitis: a case report. ( 30825277 )
2019
48
Acute Pancreatitis as a Complication of Intragastric Balloons: a Case Series. ( 30826913 )
2019
49
Chemerin alleviates acute pancreatitis in the rat thorough modulation of NF-κB signal. ( 30833212 )
2019
50
Comment on "Outcome of Acute Pancreatic and Peripancreatic Collections Occurring in Patients With Acute Pancreatitis". ( 30845014 )
2019

Variations for Acute Pancreatitis

ClinVar genetic disease variations for Acute Pancreatitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XY;t(1;6)(q23;q13)dn Translocation Uncertain significance

Expression for Acute Pancreatitis

Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for Acute Pancreatitis

Pathways related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.94 CXCL8 ELANE IL6 MPO
2 11.62 CXCL8 IL10 IL6
3 11.49 CXCL8 IL10 IL6
4 11.47 CXCL8 IL10 IL6 SST
5 11.19 CXCL8 IL10 IL6
6 11.12 CXCL8 IL10 IL6
7 11.01 ELANE IL6 MPO
8 10.25 CCK SCT
9 10.08 CRP CXCL8 IL6

GO Terms for Acute Pancreatitis

Cellular components related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 APOC2 CCK CPB1 CRP CTSB CXCL8
2 extracellular space GO:0005615 9.58 APOC2 CCK CPB1 CRP CTSB CXCL8
3 chylomicron GO:0042627 9.16 APOC2 LPL

Biological processes related to Acute Pancreatitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 CRP CXCL8 IL10 IL6 REG3A
2 acute-phase response GO:0006953 9.5 CRP IL6 REG3A
3 response to molecule of bacterial origin GO:0002237 9.49 CXCL8 IL10
4 negative regulation of lipid storage GO:0010888 9.48 CRP IL6
5 very-low-density lipoprotein particle remodeling GO:0034372 9.46 APOC2 LPL
6 lipid catabolic process GO:0016042 9.46 APOC2 LPL PLA2G6 PNLIP
7 chylomicron remodeling GO:0034371 9.43 APOC2 LPL
8 regulation of signaling receptor activity GO:0010469 9.43 CCK CXCL8 IL10 IL6 SCT SST
9 response to yeast GO:0001878 9.37 ELANE MPO
10 negative regulation of chemokine biosynthetic process GO:0045079 9.26 ELANE IL6
11 negative regulation of growth of symbiont in host GO:0044130 8.8 ELANE IL10 MPO

Sources for Acute Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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