MCID: ACT027
MIFTS: 60

Acute Pancreatitis

Categories: Bone diseases, Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Pancreatitis

MalaCards integrated aliases for Acute Pancreatitis:

Name: Acute Pancreatitis 12 75 37 29 55 6 15 63 17 72 33
Pancreatitis, Acute Necrotizing 72
Acute Necrotizing Pancreatitis 12
Pancreatitis Necrotizing 12
Necrotizing Pancreatitis 55

Classifications:



External Ids:

Disease Ontology 12 DOID:2913
KEGG 37 H01681
ICD9CM 35 577.0
NCIt 50 C95437
SNOMED-CT 68 39726008
ICD10 33 K85 K85.9
UMLS 72 C0001339 C0267941

Summaries for Acute Pancreatitis

KEGG : 37
Acute pancreatitis ranges from a mild, self- limiting disease to a life-threatening condition with multiple organ failure. Abdominal pain is the predominant symptom. Nausea and vomiting may accompany the pain. Patients frequently have a low-grade fever, tachycardia, and hypotension. The most common causes of acute pancreatitis are alcohol abuse and gallstones. The currently accepted pathogenic mechanism includes autodigestion and acute inflammation of the pancreas by the activation of proteases of the pancreas and acute inflammatory cells. Severe acute pancreatitis is defined by the presence of organ failure persisting beyond 48 hour. Organ failure that develops during the early phase is set in motion by the activation of cytokine cascades resulting in systemic inflammatory response syndrome (SIRS). Although effective therapies for acute pancreatitis are still limited, protease inhibitors have been considered to be a potential treatment to inhibit the pancreatic inflammation.

MalaCards based summary : Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to recurrent acute pancreatitis and acute respiratory distress syndrome. An important gene associated with Acute Pancreatitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Amoebiasis. The drugs Dexmedetomidine and Cefoperazone have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and liver, and related phenotype is homeostasis/metabolism.

PubMed Health : 63 About acute pancreatitis: Acute pancreatitis is an inflammation of the pancreas that typically causes very sudden and very severe stomach ache. The most common causes are gallstones and excessive alcohol consumption. Acute pancreatitis can have serious complications, so it is typically treated in the hospital. Most of the time it passes without any serious problems developing in about one to two weeks. But in more severe cases of pancreatitis, treating the complications may take up to several months. Complications of pancreatitis can be fatal.

Wikipedia : 75 Acute pancreatitis is a sudden inflammation of the pancreas. Causes in order of frequency include a... more...

Related Diseases for Acute Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Autoimmune Pancreatitis
Acute Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1001)
# Related Disease Score Top Affiliating Genes
1 recurrent acute pancreatitis 34.4 SPINK1 SCT LPL
2 acute respiratory distress syndrome 32.0 IL6 ELANE CXCL8
3 toxic shock syndrome 31.6 IL6 IL10 CXCL8
4 cholangitis 31.6 IL6 GPT CRP
5 cholelithiasis 31.6 SST GPT CCK
6 respiratory failure 31.5 ELANE CXCL8 CRP
7 colitis 31.3 MPO IL6 IL10 CXCL8
8 peritonitis 31.3 MPO IL6 IL10 CXCL8 CRP
9 pulmonary edema 31.3 IL10 CXCL8 CRP
10 obstructive jaundice 31.3 IL6 GPT CXCL8 CRP
11 alcoholic pancreatitis 31.2 SPINK1 SCT LPL CCK
12 ulcerative colitis 31.2 MPO IL6 IL10 CXCL8 CRP
13 adult respiratory distress syndrome 31.1 IL6 IL10 ELANE CXCL8
14 gastroenteritis 31.1 IL6 IL10 CXCL8 CRP
15 inflammatory bowel disease 31.1 MPO IL6 IL10 CXCL8 CRP
16 acute cystitis 31.0 IL6 CXCL8 CRP
17 leptospirosis 31.0 IL6 IL10 CXCL8 CRP
18 vasculitis 31.0 MPO ELANE CRP
19 hemorrhagic fever with renal syndrome 31.0 IL6 CXCL8 CRP
20 paralytic ileus 31.0 CRP CCK
21 appendicitis 30.9 MPO IL6 IL10 CXCL8 CRP
22 pancreatic agenesis 1 30.9 SPINK1 SCT PNLIP
23 peptic ulcer disease 30.9 SCT IL10 CXCL8
24 acalculous cholecystitis 30.9 CRP CCK
25 dengue hemorrhagic fever 30.9 IL6 IL10 CXCL8
26 brucellosis 30.9 IL6 IL10 CXCL8 CRP
27 polyarteritis nodosa 30.8 MPO IL6 CRP
28 bacterial infectious disease 30.7 IL6 IL10 ELANE CXCL8 CRP
29 biliary dyskinesia 30.7 SCT CCK
30 pleurisy 30.7 MPO CXCL8 CRP
31 dyspepsia 30.7 SST CXCL8 CCK
32 duodenal ulcer 30.6 SST SCT CXCL8 CCK
33 scrub typhus 30.6 IL10 GPT CRP
34 pyelonephritis 30.6 IL6 IL10 CXCL8 CRP
35 meningitis 30.6 IL6 IL10 CXCL8 CRP
36 acute cholangitis 30.6 IL6 CRP
37 sleep apnea 30.5 IL6 CXCL8 CRP
38 rapidly progressive glomerulonephritis 30.5 MPO ELANE CRP
39 proteasome-associated autoinflammatory syndrome 1 30.5 MPO IL6 IL10 ELANE CXCL8 CRP
40 mouth disease 30.5 IL6 IL10 CRP
41 endocarditis 30.4 IL6 IL10 CXCL8 CRP
42 streptococcal toxic-shock syndrome 30.4 IL6 CXCL8
43 cystitis 30.4 IL6 CXCL8 CRP
44 mononeuritis multiplex 30.4 MPO CRP
45 bacterial sepsis 30.4 IL10 ELANE CXCL8 CRP
46 capillary leak syndrome 30.4 IL6 ELANE CXCL8
47 vascular disease 30.4 MPO LPL IL6 ELANE CRP
48 mesenteric lymphadenitis 30.3 REG3A IL6 CRP
49 osteomyelitis 30.3 IL6 IL10 CXCL8
50 intestinal disease 30.3 MPO IL6 IL10 CXCL8 CRP

Comorbidity relations with Acute Pancreatitis via Phenotypic Disease Network (PDN): (show all 34)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Alcoholic Gastritis Alcoholic Hepatitis
Alcoholic Liver Cirrhosis Atrophic Gastritis
Biliary Tract Disease Cholangitis
Cholecystitis Cholestasis
Deficiency Anemia Duodenitis
Esophageal Disease Esophagitis
Gallbladder Disease Heart Disease
Hepatitis Hyperlipoproteinemia, Type Iv
Hypertension, Essential Hypothyroidism
Intestinal Obstruction Iron Deficiency Anemia
Irritable Bowel Syndrome Liver Disease
Pancreatic Agenesis 1 Pancreatic Cancer
Pancreatitis, Hereditary Paralytic Ileus
Postcholecystectomy Syndrome Protein-Energy Malnutrition
Respiratory Failure Strawberry Gallbladder

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to Acute Pancreatitis

Symptoms & Phenotypes for Acute Pancreatitis

MGI Mouse Phenotypes related to Acute Pancreatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 APOC2 CCK CRP CTSB ELANE IL10

Drugs & Therapeutics for Acute Pancreatitis

PubMed Health treatment related to Acute Pancreatitis: 63

No treatment is available for dealing with the root cause of pancreatitis. But there are a number of options for reducing strain on the pancreas and relieving symptoms. Because fluid levels can drop due to acute pancreatitis, the first step is to prevent dehydration by using infusion therapy. A hollow needle inserted in an arm vein is used to release a solution into the bloodstream. Medication is used to provide relief from pain, nausea and vomiting. Stronger painkillers such as opioids are sometimes needed, and they may make you feel drowsy or light-headed. Solid foods are avoided until the pain recedes and appetite returns to give the pancreas a chance to recuperate. In mild cases of pancreatitis it is sometimes possible to return to eating solid foods after just a few days. If the symptoms last longer, artificial feeding may be necessary to supply your body with enough nutrients. If the pancreatitis is caused by gallstones, the stones may need to be removed using endoscopic retrograde cholangiography. After treatment the gallbladder is surgically removed to prevent further episodes.

Drugs for Acute Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 282)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
2
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185
3
Acetaminophen Approved Phase 4 103-90-2 1983
4
Clonidine Approved Phase 4 4205-90-7 2803
5
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
6
Nefopam Approved, Investigational Phase 4 13669-70-0
7
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
8
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
9
Meropenem Approved, Investigational Phase 4 119478-56-7, 96036-03-2 64778 441130
10
Metronidazole Approved Phase 4 443-48-1 4173
11
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
12
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
13
Protein C Approved Phase 4
14
Glucagon Approved Phase 4 16941-32-5
15
Liraglutide Approved Phase 4 204656-20-2 44147092
16
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
17
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
18
Zinc Approved, Investigational Phase 4 7440-66-6 32051
19
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
20
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
21
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
22
Fenbendazole Vet_approved Phase 4 43210-67-9 3334
23 Adrenergic alpha-2 Receptor Agonists Phase 4
24 Hypnotics and Sedatives Phase 4
25 Disinfectants Phase 4
26 Sulperazone Phase 4
27 Renal Agents Phase 4
28 Anti-Infective Agents, Urinary Phase 4
29 Antipyretics Phase 4
30 Olive Phase 4
31 Antioxidants Phase 4
32 Fat Emulsions, Intravenous Phase 4
33 Parenteral Nutrition Solutions Phase 4
34 Soy Bean Phase 4
35 Soybean oil, phospholipid emulsion Phase 4
36 Platelet Aggregation Inhibitors Phase 4
37 Antineoplastic Agents, Phytogenic Phase 4
38 Cyclooxygenase 2 Inhibitors Phase 4
39 Anti-Infective Agents Phase 4
40 Polygeline Phase 4
41 Antiparasitic Agents Phase 4
42 Hormone Antagonists Phase 4
43 Antiprotozoal Agents Phase 4
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
45 Fibrinolytic Agents Phase 4
46 Cilastatin, Imipenem Drug Combination Phase 4
47 Anticoagulants Phase 4
48 insulin Phase 4
49 Insulin, Globin Zinc Phase 4
50 Anti-Obesity Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 271)
# Name Status NCT ID Phase Drugs
1 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Unknown status NCT02691598 Phase 4 Infusion
2 Escalade or Deseacalade Antibiotic Use in Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
3 A MULTICENTER, RANDOMIZED, CONTROLLED STUDY OF EPIDURAL ANALGESIA FOR SEVERE ACUTE PANCREATITIS Unknown status NCT02126332 Phase 4
4 Comparative Study About the Impact of Two Oil Emulsions, One of Them Formulated With MCT, LCT, Olive Oil and Omega 3 Fatty Acids Versus Another One Formulated With MCT and LCT, Administered Intravenously on Severe Acute Pancreatitis Clinical Evolution Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
5 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study. Unknown status NCT03082469 Phase 4
6 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
7 Oral Resveratrol Before ERCP Redused Overall Pancreatitis in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Multi-center, Single-blinded, Randomized Controlled Trial Unknown status NCT02947932 Phase 4 Resveratrol;Indomethacin
8 Effect Observation Study of COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis Unknown status NCT02964403 Phase 4 Cox-2;Indomethacin
9 The Impact of Early Enteral Nutrition on the Clinical Outcomes of Severe Acute Pancreatitis Patients: A Randomized Control Trial Completed NCT00995098 Phase 4
10 A Multicentre, Randomised, Double-blind, Placebo-controlled, Study on the Use of Prophylactic Meropenem Therapy in Subjects With Severe Acute Necrotizing Pancreatitis Completed NCT00061438 Phase 4 meropenem
11 Enteral Nutrition for Treatment of Acute Pancreatitis - a Prospective, Randomized Clinical Trial Completed NCT01965873 Phase 4
12 Imipenem Prophylaxis of Infectious Complications in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
13 Randomized Controlled Trial on Sterile Fluid Collections Management in Acute Pancreatitis Completed NCT00786929 Phase 4 Conservative treatment
14 APCAP - Activated Protein C in Severe Acute Pancreatitis: A Double-blind Randomized Human Pilot Trial Completed NCT01017107 Phase 4 Activated protein C
15 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
16 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
17 A Prospective Randomised Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
18 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Randomized Multi-center Study Completed NCT01744847 Phase 4
19 Studie Naar De Effectiviteit Van Ursodeoxycholzuur Ter Preventie Van Galsteen-Gerelateerde Klachten Bij patiënten in Afwachting Van Een Cholecystectomie Completed NCT00161083 Phase 4 ursodeoxycholic acid
20 A Phase IV, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial to Assess the Effect of 12-week Treatment With the Glucagon-like Peptide-1 Receptor Agonist (GLP-1RA) Liraglutide or Dipeptidyl Peptidase-4 Inhibitor (DPP-4i) Sitagliptin on the Cardiovascular, Renal and Gastrointestinal System in Insulin-naïve Patients With Type 2 Diabetes (T2DM). Completed NCT01744236 Phase 4 Liraglutide;Sitagliptin;Exenatide;Liraglutide placebo;Sitagliptin placebo;Exenatide placebo;L-NMMA
21 Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial: The EFFORT Trial Completed NCT02517476 Phase 4
22 Calcium Administration in Patients Undergoing Cardiac Surgery Under Cardiopulmonary Bypass (ICARUS Trial): Prospective Randomized, Double-blind Placebo-controlled Superiority Trial Recruiting NCT03772990 Phase 4 Calcium Chloride;0.9% Sodium Chloride
23 Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT) Recruiting NCT02462590 Phase 4 L. rhamnosus GG - Probiotic;Placebo - Microcrystalline Cellulose
24 Randomized, Controlled, Multicenter Studies of the Effects of Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis Not yet recruiting NCT03342807 Phase 4 Insulin
25 Randomized, Controlled, Open-label Trial of Intravenous Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis. Not yet recruiting NCT03501680 Phase 4 Insulin
26 A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis Not yet recruiting NCT02465138 Phase 4 Ketorolac;Placebo
27 Multicenter, Double-bind, Randomised, Placebo Controlled Study of Ulinastatin in Severe Acute Pancreatitis Suspended NCT01132521 Phase 4 ulinastatin;placebo
28 Treatment of Acute Pancreatitis With Ketorolac Terminated NCT02885441 Phase 4 Ketorolac
29 Diclofenac for the Prevention of Post-ERCP Pancreatitis in Higher Risk Patients: A Prospective, Randomized, Double Blind, Placebo Controlled Trial. Terminated NCT00428025 Phase 4 diclofenac;placebo
30 Thiopurine Induced Pancreatitis in IBD Patients Withdrawn NCT02281799 Phase 4 Azathioprine
31 Effect of Traditional Chinese Medicine on Gastrointestinal Function Recovery and Nutrition Support in Severe Acute Pancreatitis Unknown status NCT00508729 Phase 2, Phase 3 Qingyi granules
32 Evaluation of Effect of Integrated Treatment by Traditional Chinese and Western Medicine for Severe Acute Pancreatitis Unknown status NCT00506337 Phase 2, Phase 3 Qingyi granules
33 Epidural Anesthesia as an Alternative for Management in Acute Pancreatitis, a Randomised Clinical Trial Unknown status NCT02617199 Phase 2, Phase 3 Epidural anesthesia;intravenous analgesia
34 Randomized Trial of Standard vs. Enhanced Hydration in Patients With a Diagnosis of Acute Pancreatitis Within the First Hour of the Diagnosis Unknown status NCT02709044 Phase 2, Phase 3 Ringer lactate
35 Randomized, Double-blind Study to Evaluate the Efficacy of Administration With Intravenous Bolus Followed by a Continuous Infusion of Somatostatin in the Prevention of Post-ERCP Pancreatitis Unknown status NCT01060826 Phase 3 somatostatin, intravenous bolus;somatostatin
36 A Study to Determine the Safety and Efficacy in Lipoprotein Lipase-Deficient Subjects After Intramuscular Administration of AMT-011, an Adeno-Associated Viral Vector Expressing Human Lipoprotein LipaseS447X Unknown status NCT01109498 Phase 2, Phase 3 Mycophenolate mofetil;cyclosporine
37 Effect of Saline Irrigation to Decrease Rate of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
38 Phase 2/3 Study of Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis Completed NCT01977118 Phase 2, Phase 3 streptokinase
39 Early Enteral Tube Feeding Compared With Pancreas Rest in Patients With Acute Pancreatitis: a Randomized Controlled Trial Completed NCT01128478 Phase 2, Phase 3
40 Pentoxifylline Treatment in Acute Pancreatitis: A Double-Blind Placebo - Controlled Randomized Trial Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
41 Effects of Delayed Enteral Nutrition on Inflammatory Responses and Immune Function Competence in Critically Ill Patients With Prolonged Fasting Completed NCT01834430 Phase 3
42 A Prospective Open-label Randomized Controlled Trial Comparing Effectiveness of Aggressive Hydration Versus High-dose Rectal Indomethacin in the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT03629600 Phase 2, Phase 3 Lactated Ringer;Rectal Form Indometacin
43 Rectal Indomethacin Decreases the Incidence of Pancreatitis Following Endoscopic Retrograde Cholangiopancreatography in High-risk Patients Completed NCT02110810 Phase 3 Indomethacin;2.6-g suppository of glycerin
44 Prevention of Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) - Induced Pancreatitis Using Aggressive Lactated Ringer's Infusion and/or Rectal Indomethacin Completed NCT02641561 Phase 3 Indomethacin;Lactated Ringer's Solution;Normal Saline;Placebo
45 An Open-label Study to Assess the Efficacy and Safety of Alipogene Tiparvovec (AMT-011), Human LPL [S447X], Expressed by an Adeno-Associated Viral Vector After Intramuscular Administration in LPL-deficient Adult Subjects Completed NCT00891306 Phase 2, Phase 3 mycophenolate mofetil;cyclosporine;methylprednisolone
46 Does Glyceryl Nitrate Prevent Post-Endoscopic Retrograde Cholangiopancreaticography (ERCP) Pancreatitis? Completed NCT00121901 Phase 3 glyceryl nitrate
47 Dexamethasone Improves Postoperative Symptoms in Patients Undergoing Elective Laparoscopic Cholecystectomy: A Randomised Clinical Trial. Completed NCT01030614 Phase 3 Dexamethasone;placebo
48 A Randomized Controlled Trial of Indomethacin in Acute Pancreatitis- Effectiveness and Safety Recruiting NCT03547232 Phase 3 Indomethacin SR;Placebos
49 Simvastatin in the Prevention of Recurrent Acute Pancreatitis, a Triple Blind, Randomized Controlled Trial Recruiting NCT04021498 Phase 3 Simvastatin 40mg
50 A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis Recruiting NCT02692391 Phase 3 Indomethacin;Placebo

Search NIH Clinical Center for Acute Pancreatitis

Genetic Tests for Acute Pancreatitis

Genetic tests related to Acute Pancreatitis:

# Genetic test Affiliating Genes
1 Acute Pancreatitis 29

Anatomical Context for Acute Pancreatitis

MalaCards organs/tissues related to Acute Pancreatitis:

41
Pancreas, Lung, Liver, Testes, Neutrophil, Colon, Kidney

Publications for Acute Pancreatitis

Articles related to Acute Pancreatitis:

(show top 50) (show all 22604)
# Title Authors PMID Year
1
Obesity and the risk of severe acute pancreatitis. 9 38
20485254 2010
2
Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype. 9 38
20110462 2010
3
Different profiles of cytokine expression during mild and severe acute pancreatitis. 9 38
20397261 2010
4
-651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan. 9 38
19997857 2010
5
Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis. 9 38
19844201 2010
6
New diagnostic criteria of acute pancreatitis. 9 38
20012328 2010
7
[Influence of integrated traditional Chinese and Western medicine therapy on serum resistin levels in patients with severe acute pancreatitis: a randomized controlled trial]. 9 38
20015433 2009
8
[Effect of qingyi decoction in treating severe acute pancreatitis and its impacts on blood level of tumor necrosis factor-alpha, interleukin-6 and inteleukin-8]. 9 38
20214338 2009
9
Pathogenic role of myeloperoxidase in acute pancreatitis. 9 38
20007081 2009
10
Alipogene tiparvovec, an adeno-associated virus encoding the Ser(447)X variant of the human lipoprotein lipase gene for the treatment of patients with lipoprotein lipase deficiency. 9 38
20072945 2009
11
Role of pancreatitis-associated protein 1 on oxidative stress-induced cell death of pancreatic acinar cells. 9 38
19723102 2009
12
Simultaneous proteosome inhibition and heat shock protein induction by bortezomib is beneficial in experimental pancreatitis. 9 38
19486901 2009
13
Efficacy of recombinant human interleukin-10 in prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis in subjects with increased risk. 9 38
19214137 2009
14
A combined in vitro and in vivo study on the interactions between somatostatin and lipid-based liquid crystalline drug carriers and bilayers. 9 38
19041716 2009
15
Can wire-guided cannulation prevent post-ERCP pancreatitis? A prospective randomized trial. 9 38
19007927 2009
16
Microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene is associated with susceptibility to acute pancreatitis in Japan. 9 38
19280717 2009
17
Pancreatitis-associated protein is related closely to neoplastic proliferative activity in patients with colorectal carcinoma. 9 38
19051257 2009
18
[The study of the relationship between interleukin gene polymorphism and the morbidity of patients with acute pancreatitis]. 9 38
19220961 2009
19
Activated protein C-protein C inhibitor complex, activation peptide of carboxypeptidase B and C-reactive protein as predictors of severe acute pancreatitis. 9 38
19684435 2009
20
Serum profiles of C-reactive protein, interleukin-8, and tumor necrosis factor-alpha in patients with acute pancreatitis. 9 38
20130823 2009
21
Diagnostic accuracy of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: a meta-analysis. 9 38
20110745 2009
22
Significance of endothelial molecular markers in the evaluation of the severity of acute pancreatitis. 9 38
19319639 2009
23
Acute pancreatitis as a model of SIRS. 9 38
19273184 2009
24
Acute pancreatitis in a girl with panhypopituitarism due to craniopharyngioma on growth hormone treatment. A combination of risk factors. 9 38
19506396 2009
25
Icam-1 and acute pancreatitis complicated by acute lung injury. 9 38
19129609 2009
26
[Relationship between acute pancreatitis and systemic inflammation response syndrome in children]. 9 38
19102837 2008
27
[Interleukin 18 (IL-18) and other immunological parameters as markers of severity in acute pancreatitis]. 9 38
19222336 2008
28
Effect of somatostatin in the prevention of pancreatic complications after endoscopic retrograde cholangiopancreatography. 9 38
19114324 2008
29
Morbimortality indicators in severe acute pancreatitis. 9 38
18981549 2008
30
Molecular basis for pancreatitis. 9 38
19122498 2008
31
Implication of interleukin 18 and intercellular adhesion molecule (ICAM)-1 in acute pancreatitis. 9 38
19102398 2008
32
Pancreatitis-associated protein 2 modulates inflammatory responses in macrophages. 9 38
18641332 2008
33
The SPINK1 N34S variant is associated with acute pancreatitis. 9 38
18617776 2008
34
Therapy for acute pancreatitis with platelet-activating factor receptor antagonists. 9 38
18720532 2008
35
The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats. 9 38
18486906 2008
36
Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice. 9 38
18515422 2008
37
[Acute pancreatitis secondary to hypertriglyceridemia - a report of two cases]. 9 38
18752369 2008
38
Ritonavir and disulfiram may be synergistic in lowering active interleukin-18 levels in acute pancreatitis, and thereby hasten recovery. 9 38
18469453 2008
39
[Utility of endoscopic ultrasonography in the etiological diagnosis of patients with acute idiopathic pancreatitis]. 9 38
18405484 2008
40
Is there correlation between pancreatic enzyme and radiological severity in acute pancreatitis? 9 38
18416469 2008
41
Acute pancreatitis. 9 38
18388680 2008
42
Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. 9 38
18160487 2008
43
[Pancreatitis in pregnant women]. 9 38
18720707 2008
44
Protease activation, pancreatic leakage, and inflammation in acute pancreatitis: differences between mild and severe cases and changes over the first three days. 9 38
18849642 2008
45
Monocyte chemoattractant protein 1, active carboxypeptidase B and CAPAP at hospital admission are predictive markers for severe acute pancreatitis. 9 38
18235216 2008
46
Risk factors for recurrent acute alcohol-associated pancreatitis: a prospective analysis. 9 38
18415757 2008
47
TLR and MBL gene polymorphisms in severe acute pancreatitis. 9 38
18288881 2008
48
Sphincter of Oddi dysfunction and pancreatitis. 9 38
18081221 2007
49
A novel complex deletion-insertion mutation mediated by Alu repetitive elements leads to lipoprotein lipase deficiency. 9 38
17706445 2007
50
Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis. 9 38
17907957 2007

Variations for Acute Pancreatitis

ClinVar genetic disease variations for Acute Pancreatitis:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 46;XY;t(1;6)(q23;q13)dn Translocation Uncertain significance

Expression for Acute Pancreatitis

Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for Acute Pancreatitis

Pathways related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.94 MPO IL6 ELANE CXCL8
2 11.64 IL6 IL10 CXCL8
3 11.49 IL6 IL10 CXCL8
4 11.47 SST IL6 IL10 CXCL8
5 11.19 IL6 IL10 CXCL8
6 11.12 IL6 IL10 CXCL8
7 11.01 MPO IL6 ELANE
8 10.25 SCT CCK
9 10.08 IL6 CXCL8 CRP

GO Terms for Acute Pancreatitis

Cellular components related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 SST SPINK1 SCT REG3A PNLIP MPO
2 extracellular space GO:0005615 9.58 SST SPINK1 SCT REG3A PNLIP PLA2G6
3 chylomicron GO:0042627 9.16 LPL APOC2

Biological processes related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.77 REG3A IL6 IL10 CXCL8 CRP
2 response to molecule of bacterial origin GO:0002237 9.48 IL10 CXCL8
3 very-low-density lipoprotein particle remodeling GO:0034372 9.46 LPL APOC2
4 negative regulation of lipid storage GO:0010888 9.43 IL6 CRP
5 acute-phase response GO:0006953 9.43 REG3A IL6 CRP
6 chylomicron remodeling GO:0034371 9.4 LPL APOC2
7 response to yeast GO:0001878 9.32 MPO ELANE
8 lipid catabolic process GO:0016042 9.26 PNLIP PLA2G6 LPL APOC2
9 negative regulation of chemokine biosynthetic process GO:0045079 9.16 IL6 ELANE
10 negative regulation of growth of symbiont in host GO:0044130 8.8 MPO IL10 ELANE

Sources for Acute Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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