MCID: ACT027
MIFTS: 60

Acute Pancreatitis

Categories: Bone diseases, Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Pancreatitis

MalaCards integrated aliases for Acute Pancreatitis:

Name: Acute Pancreatitis 12 74 36 29 54 6 15 62 17 71 32
Pancreatitis, Acute Necrotizing 71
Acute Necrotizing Pancreatitis 12
Pancreatitis Necrotizing 12
Necrotizing Pancreatitis 54
Pancreatitis 43

Classifications:



External Ids:

Disease Ontology 12 DOID:2913
KEGG 36 H01681
ICD9CM 34 577.0
MeSH 43 D010195
NCIt 49 C95437
SNOMED-CT 67 197456007
ICD10 32 K85 K85.9
UMLS 71 C0001339 C0267941

Summaries for Acute Pancreatitis

KEGG : 36 Acute pancreatitis ranges from a mild, self- limiting disease to a life-threatening condition with multiple organ failure. Abdominal pain is the predominant symptom. Nausea and vomiting may accompany the pain. Patients frequently have a low-grade fever, tachycardia, and hypotension. The most common causes of acute pancreatitis are alcohol abuse and gallstones. The currently accepted pathogenic mechanism includes autodigestion and acute inflammation of the pancreas by the activation of proteases of the pancreas and acute inflammatory cells. Severe acute pancreatitis is defined by the presence of organ failure persisting beyond 48 hour. Organ failure that develops during the early phase is set in motion by the activation of cytokine cascades resulting in systemic inflammatory response syndrome (SIRS). Although effective therapies for acute pancreatitis are still limited, protease inhibitors have been considered to be a potential treatment to inhibit the pancreatic inflammation.

MalaCards based summary : Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to pancreatic cholera and pancreatic steatorrhea. An important gene associated with Acute Pancreatitis is CPB1 (Carboxypeptidase B1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Cefoperazone and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and liver, and related phenotype is homeostasis/metabolism.

PubMed Health : 62 About acute pancreatitis: Acute pancreatitis is an inflammation of the pancreas that typically causes very sudden and very severe stomach ache. The most common causes are gallstones and excessive alcohol consumption. Acute pancreatitis can have serious complications, so it is typically treated in the hospital. Most of the time it passes without any serious problems developing in about one to two weeks. But in more severe cases of pancreatitis, treating the complications may take up to several months. Complications of pancreatitis can be fatal.

Wikipedia : 74 Acute pancreatitis (AP) is a sudden inflammation of the pancreas. Causes in order of frequency include:... more...

Related Diseases for Acute Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Autoimmune Pancreatitis
Acute Pancreatitis Prss1-Related Hereditary Pancreatitis
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2557)
# Related Disease Score Top Affiliating Genes
1 pancreatic cholera 34.3 SST SCT
2 pancreatic steatorrhea 34.0 SCT PNLIP CCK
3 pancreatic gastrinoma 34.0 SST SCT
4 glucagonoma 33.9 SST SCT
5 mikulicz disease 32.9 SPINK1 IL10 CRP
6 familial lipoprotein lipase deficiency 32.8 PNLIP LPL APOC2
7 common bile duct disease 32.8 GPT CRP CCK
8 enterokinase deficiency 32.6 TMPRSS15 SCT CCK
9 hyperlipoproteinemia, type i 32.6 PNLIP LPL APOC2
10 maturity-onset diabetes of the young 32.2 SST LPL CRP APOC2
11 compartment syndrome 31.8 IL6 GPT CRP
12 cholelithiasis 31.7 SST GPT CRP CCK
13 bile acid malabsorption, primary 31.6 TMPRSS15 SST SCT PNLIP ELANE CCK
14 toxic shock syndrome 31.6 IL6 IL10 CXCL8 CRP
15 pertussis 31.5 SST IL6 IL10 CXCL8
16 purpura 31.5 IL6 IL10 CRP
17 ileus 31.5 SST IL6 IL10 CRP CCK
18 obstructive jaundice 31.5 IL6 GPT CXCL8 CRP
19 colitis 31.4 MPO IL6 IL10 CXCL8
20 otitis media 31.4 MPO IL6 IL10 GPT ELANE CXCL8
21 biliary tract disease 31.4 IL6 GPT CRP CCK
22 pancreatitis 31.4 VMP1 TMPRSS15 SST SPINK1 SCT REG3A
23 ulcerative colitis 31.4 MPO IL6 IL10 CXCL8 CRP
24 crohn's disease 31.4 IL6 IL10 CXCL8 CRP
25 peritonitis 31.4 MPO IL6 IL10 ELANE CXCL8 CRP
26 ascaris lumbricoides infection 31.3 IL6 IL10 CXCL8
27 acute cholangitis 31.3 IL6 GPT CRP
28 respiratory failure 31.3 MPO IL6 IL10 GPT ELANE CXCL8
29 pancreatic agenesis 1 31.3 SPINK1 SCT PNLIP
30 viral hepatitis 31.3 IL6 IL10 GPT CRP
31 hepatitis a 31.3 IL10 GPT CXCL8
32 alcoholic pancreatitis 31.3 SPINK1 SCT REG3A LPL CPB1 CCK
33 hyperglycemia 31.3 SST LPL IL6 CCK
34 chickenpox 31.3 IL6 IL10 CRP
35 cholangitis 31.3 SST MPO IL6 IL10 GPT CXCL8
36 disseminated intravascular coagulation 31.3 IL6 IL10 GPT ELANE CRP
37 fatty liver disease 31.3 IL6 GPT CXCL8 CRP
38 diabetes mellitus, type i 31.2 SST SCT IL6 IL10 CXCL8 CRP
39 pulmonary edema 31.2 IL10 CXCL8 CRP
40 mumps 31.2 IL6 IL10 CXCL8
41 vasculitis 31.2 MPO IL6 IL10 ELANE CRP
42 gastroenteritis 31.2 IL6 IL10 CXCL8 CRP
43 appendicitis 31.2 MPO IL6 IL10 CXCL8 CRP
44 leptospirosis 31.2 IL6 IL10 CXCL8 CRP
45 adult respiratory distress syndrome 31.2 MPO IL6 IL10 ELANE CXCL8
46 gastric ulcer 31.1 SST IL6 CXCL8
47 intestinal obstruction 31.1 SST IL6 GPT CRP
48 pericardial effusion 31.1 IL6 GPT CRP
49 aortic aneurysm, familial abdominal, 1 31.0 IL6 ELANE CRP
50 hypercholesterolemia, familial, 1 31.0 LPL GPT CRP

Comorbidity relations with Acute Pancreatitis via Phenotypic Disease Network (PDN): (show all 34)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Alcoholic Gastritis Alcoholic Hepatitis
Alcoholic Liver Cirrhosis Atrophic Gastritis
Biliary Tract Disease Cholangitis
Cholecystitis Cholestasis
Deficiency Anemia Duodenitis
Esophageal Disease Esophagitis
Gallbladder Disease Heart Disease
Hepatitis Hyperlipoproteinemia, Type Iv
Hypertension, Essential Hypothyroidism
Intestinal Obstruction Iron Deficiency Anemia
Irritable Bowel Syndrome Liver Disease
Pancreatic Agenesis 1 Pancreatic Cancer
Pancreatitis, Hereditary Paralytic Ileus
Postcholecystectomy Syndrome Protein-Energy Malnutrition
Respiratory Failure Strawberry Gallbladder

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to Acute Pancreatitis

Symptoms & Phenotypes for Acute Pancreatitis

MGI Mouse Phenotypes related to Acute Pancreatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 APOC2 CCK CRP CTSB ELANE IL10

Drugs & Therapeutics for Acute Pancreatitis

PubMed Health treatment related to Acute Pancreatitis: 62

No treatment is available for dealing with the root cause of pancreatitis . But there are a number of options for reducing strain on the pancreas and relieving symptoms. Because fluid levels can drop due to acute pancreatitis , the first step is to prevent dehydration by using infusion therapy . A hollow needle inserted in an arm vein is used to release a solution into the bloodstream. Medication is used to provide relief from pain, nausea and vomiting . Stronger painkillers such as opioids are sometimes needed, and they may make you feel drowsy or light-headed. Solid foods are avoided until the pain recedes and appetite returns to give the pancreas a chance to recuperate. In mild cases of pancreatitis it is sometimes possible to return to eating solid foods after just a few days. If the symptoms last longer, artificial feeding may be necessary to supply your body with enough nutrients . If the pancreatitis is caused by gallstones , the stones may need to be removed using endoscopic retrograde cholangiography. After treatment the gallbladder is surgically removed to prevent further episodes.

Drugs for Acute Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 492)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185
2
Metronidazole Approved Phase 4 443-48-1 4173
3 Pinaverium Approved Phase 4 59995-65-2
4
Lorazepam Approved Phase 4 846-49-1 3958
5
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
6
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
7
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
8
Meropenem Approved, Investigational Phase 4 96036-03-2, 119478-56-7 441130 64778
9
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
10
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
11
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
12
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
13
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
14
Morphine Approved, Investigational Phase 4 57-27-2 5288826
15
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
16
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
17
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
18
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
19
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
20
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
21
Ceftazidime Approved Phase 4 72558-82-8, 78439-06-2 5481173
22
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
23
Thrombin Approved, Investigational Phase 4
24
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
25
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
26
Meperidine Approved Phase 4 57-42-1 4058
27
Etomidate Approved Phase 4 33125-97-2 36339 667484
28
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
29
Glycolic acid Approved, Investigational Phase 4 79-14-1 757
30
Lopinavir Approved Phase 4 192725-17-0 92727
31
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
32
Darunavir Approved Phase 4 206361-99-1, 635728-49-3 213039
33 Hydrotalcite Approved, Experimental, Investigational Phase 4 12304-65-3
34
Sucralfate Approved Phase 4 54182-58-0
35
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
36
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
37
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
38
Polyestradiol phosphate Approved Phase 4 28014-46-2
39
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
40
Protein C Approved Phase 4
41
Glycerol Approved, Investigational Phase 4 56-81-5 753
42
Secretin Approved Phase 4 108153-74-8
43
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
44
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
45
Etanercept Approved, Investigational Phase 4 185243-69-0
46
Ceftriaxone Approved Phase 4 73384-59-5 5361919 5479530
47
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
48
Ofloxacin Approved Phase 4 82419-36-1 4583
49
Fosaprepitant Approved Phase 4 172673-20-0 219090
50
Palonosetron Approved, Investigational Phase 4 135729-56-5, 119904-90-4 148211

Interventional clinical trials:

(show top 50) (show all 821)
# Name Status NCT ID Phase Drugs
1 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Unknown status NCT02691598 Phase 4 Infusion
2 Escalade or Deseacalade Antibiotic Use in Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
3 Comparative Study About the Impact of Two Oil Emulsions, One of Them Formulated With MCT, LCT, Olive Oil and Omega 3 Fatty Acids Versus Another One Formulated With MCT and LCT, Administered Intravenously on Severe Acute Pancreatitis Clinical Evolution Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
4 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study. Unknown status NCT03082469 Phase 4
5 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
6 Oral Resveratrol Before ERCP Redused Overall Pancreatitis in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Multi-center, Single-blinded, Randomized Controlled Trial Unknown status NCT02947932 Phase 4 Resveratrol;Indomethacin
7 Effect Observation Study of COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis Unknown status NCT02964403 Phase 4 Cox-2;Indomethacin
8 Prophylactic Pancreatic Duct Stent Placement After Endoscopic Snare Papillectomy of Duodenal Major Papillary Tumors; Prospective, Randomized, Controlled Study Unknown status NCT01737463 Phase 4
9 The Effect of Application of Fibrinogen/Thrombin-coated Collagen Patch (TachoSil®) in Pancreaticojejunostomy for Prevention of Pancreatic Fistula After Pancreatoduodenectomy Unknown status NCT03269955 Phase 4 Fibrinogen/thrombin-coated collagen patch
10 Application of Pinaverium Bromide in the Treatment of Patients With Post-cholecystectomy Sphincter of Oddi Dysfunction (SOD): A Randomized, Controlled and Multicenter Clinical Study Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
11 DOLCE Study: Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized, Controlled Trial Unknown status NCT01052727 Phase 4
12 Dose Related Decrease in Triglycerides in Patients With Hypertriglyceridemia and Treated With Lovaza. Unknown status NCT00934219 Phase 4 Omega-3-Acid Ethyl Esters
13 An Open Pilot Study to Evaluate the Efficacy and Safety, Tolerability of Raltegravir(RAL)in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
14 Prospective Assessment of Valproate on Ethanol Withdrawal Unknown status NCT03235531 Phase 4 Valproate;Lorazepam
15 A Multicentre, Randomised, Double-blind, Placebo-controlled, Study on the Use of Prophylactic Meropenem Therapy in Subjects With Severe Acute Necrotizing Pancreatitis Completed NCT00061438 Phase 4 meropenem
16 The Impact of Early Enteral Nutrition on the Clinical Outcomes of Severe Acute Pancreatitis Patients: A Randomized Control Trial Completed NCT00995098 Phase 4
17 Enteral Nutrition for Treatment of Acute Pancreatitis - a Prospective, Randomized Clinical Trial Completed NCT01965873 Phase 4
18 Imipenem Prophylaxis of Infectious Complications in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
19 Randomized Controlled Trial on Sterile Fluid Collections Management in Acute Pancreatitis Completed NCT00786929 Phase 4 Conservative treatment
20 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
21 APCAP - Activated Protein C in Severe Acute Pancreatitis: A Double-blind Randomized Human Pilot Trial Completed NCT01017107 Phase 4 Activated protein C
22 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
23 A Prospective Randomised Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
24 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Randomized Multi-center Study Completed NCT01744847 Phase 4
25 Studie Naar De Effectiviteit Van Ursodeoxycholzuur Ter Preventie Van Galsteen-Gerelateerde Klachten Bij patiënten in Afwachting Van Een Cholecystectomie Completed NCT00161083 Phase 4 ursodeoxycholic acid
26 Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis Completed NCT00957151 Phase 4 Creon
27 Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis Completed NCT00318994 Phase 4 Meropenem
28 A Phase IV, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial to Assess the Effect of 12-week Treatment With the Glucagon-like Peptide-1 Receptor Agonist (GLP-1RA) Liraglutide or Dipeptidyl Peptidase-4 Inhibitor (DPP-4i) Sitagliptin on the Cardiovascular, Renal and Gastrointestinal System in Insulin-naïve Patients With Type 2 Diabetes (T2DM). Completed NCT01744236 Phase 4 Liraglutide;Sitagliptin;Exenatide;Liraglutide placebo;Sitagliptin placebo;Exenatide placebo;L-NMMA
29 Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial: The EFFORT Trial Completed NCT02517476 Phase 4
30 A Prospective Study of Celiac Block Technique: One Injection or Two? Completed NCT00583479 Phase 4
31 Double-blind Randomized Study to Determine the Efficacy of Intramuscular Vitamin D3 Supplementation in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
32 Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube Completed NCT00999232 Phase 4 Erythromycin;Placebo
33 Diclophenac Potassium Versus Ceftazidime for Reduction of Post ERCP Pancreatitis in Average Risk Patients-double Blind, Randomised Controlled Trial Completed NCT01784445 Phase 4 Ceftazidime
34 Dexmedetomidine vs Placebo in ERCP Sedation.A Randomized Pilot Study Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
35 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
36 A Double-Blind, Randomized, Placebo Controlled Intervention Study to Assess the Impact of Sitagliptin 100 mg/Day for 1 Year on Insulin Independence Following Pancreatectomy and Autoislet Transplantation Completed NCT01186562 Phase 4 Sitagliptin;Placebo
37 Enzyme Substitution in Exocrine Pancreatic Insufficiency; Self Administration Against a Fixed Dose Regimen Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
38 Covered Versus Uncovered Metal Stents for Management of Distal Malignant Biliary Obstruction? Results of a Randomized Prospective Study. Completed NCT00280709 Phase 4
39 Pilot Study for the Evaluation of the Safety and the Feasibility of Treatment Simplification to Atazanavir/Ritonavir + Lamivudine in Patients Stably Treated With Two NRTIs + Atazanavir/Ritonavir With Optimal Virologic Response. Completed NCT00885482 Phase 4 Lamiduvine (Epivir);Atazanavir (Reyataz);Ritonavir (Norvir)
40 A Study of Safety and Efficacy of Leflunomide for Maintenance of Remission in IgG4 Related Disease Completed NCT02703194 Phase 4 Prednisone;Leflunomide
41 Beijing Chao-Yang Hospital, Capital Medical University Completed NCT03297879 Phase 4 Exenatide or metformin hydrochloride
42 Etomidate With Meperidine vs Midazolam With Meperidine for Sedation During Endodscopic Retrograde Cholangiopancreatogram (ERCP) Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
43 A Pilot Study for the Use of Biomarkers and Early Treatment of Invasive Candidiasis in ICU Patients Completed NCT01734525 Phase 4 Anidulafungin
44 Use of Polyethylene Glycolic Acid or Tachocomb to Prevent Pancreatic Fistula Following Distal Pancreatectomy: Prospective Multicenter Randomized Study Completed NCT01550406 Phase 4
45 Exploratory, Cross-sectional Study to Compare the Virologic Efficacy in Cerebrospinal Fluid (CSF) and Neurocognitive State in Patients Infected by HIV-1 Long-term Treatment (> 3 Years) With Lopinavir / Ritonavir Monotherapy Completed NCT01116817 Phase 4 Lumbar puncture (Lopinavir/ritonavir monotherapy);Lumbar puncture (HAART: Lopinavir/ritonavir + 2 NRTI)
46 A Randomised, Double Blind Cross-over Study of Serial MRCP Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
47 Evaluation of Safety and Efficacy of Raltegravir/Darunavir Combination in Antiretroviral-Naive Patients Completed NCT00677300 Phase 4 Raltegravir;Darunavir;Ritonavir;Tenofovir/Emtricitabine
48 A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment: Randomized Trial Completed NCT03635372 Phase 4 Alginate;Sucralfate;Hydrotalcite
49 Randomised and Prospective Clinical Study to Evaluate the Efficacy and Safety of Lopinavir/Ritonavir Monotherapy Versus Darunavir/Ritonavir Monotherapies as Simplification Switching Strategies of PI/NNRTI-Triple Therapy Based-Regimens Completed NCT00994344 Phase 4 Darunavir/ritonavir;Lopinavir/ritonavir
50 To Study the Effects of Lipid Emulsion on Hemodynamics in Organophosphate Compound Poisoning Completed NCT03564574 Phase 4

Search NIH Clinical Center for Acute Pancreatitis

Cochrane evidence based reviews: pancreatitis

Genetic Tests for Acute Pancreatitis

Genetic tests related to Acute Pancreatitis:

# Genetic test Affiliating Genes
1 Acute Pancreatitis 29

Anatomical Context for Acute Pancreatitis

MalaCards organs/tissues related to Acute Pancreatitis:

40
Pancreas, Lung, Liver, Testes, Neutrophil, Kidney, Colon

Publications for Acute Pancreatitis

Articles related to Acute Pancreatitis:

(show top 50) (show all 23458)
# Title Authors PMID Year
1
Obesity and the risk of severe acute pancreatitis. 61 54
20485254 2010
2
Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype. 61 54
20110462 2010
3
Different profiles of cytokine expression during mild and severe acute pancreatitis. 54 61
20397261 2010
4
-651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan. 61 54
19997857 2010
5
Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis. 61 54
19844201 2010
6
New diagnostic criteria of acute pancreatitis. 54 61
20012328 2010
7
Pathogenic role of myeloperoxidase in acute pancreatitis. 54 61
20007081 2009
8
[Effect of qingyi decoction in treating severe acute pancreatitis and its impacts on blood level of tumor necrosis factor-alpha, interleukin-6 and inteleukin-8]. 54 61
20214338 2009
9
[Influence of integrated traditional Chinese and Western medicine therapy on serum resistin levels in patients with severe acute pancreatitis: a randomized controlled trial]. 61 54
20015433 2009
10
Alipogene tiparvovec, an adeno-associated virus encoding the Ser(447)X variant of the human lipoprotein lipase gene for the treatment of patients with lipoprotein lipase deficiency. 61 54
20072945 2009
11
Role of pancreatitis-associated protein 1 on oxidative stress-induced cell death of pancreatic acinar cells. 61 54
19723102 2009
12
Simultaneous proteosome inhibition and heat shock protein induction by bortezomib is beneficial in experimental pancreatitis. 61 54
19486901 2009
13
Efficacy of recombinant human interleukin-10 in prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis in subjects with increased risk. 61 54
19214137 2009
14
Can wire-guided cannulation prevent post-ERCP pancreatitis? A prospective randomized trial. 61 54
19007927 2009
15
Microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene is associated with susceptibility to acute pancreatitis in Japan. 61 54
19280717 2009
16
A combined in vitro and in vivo study on the interactions between somatostatin and lipid-based liquid crystalline drug carriers and bilayers. 61 54
19041716 2009
17
[The study of the relationship between interleukin gene polymorphism and the morbidity of patients with acute pancreatitis]. 61 54
19220961 2009
18
Pancreatitis-associated protein is related closely to neoplastic proliferative activity in patients with colorectal carcinoma. 54 61
19051257 2009
19
Acute pancreatitis as a model of SIRS. 54 61
19273184 2009
20
Diagnostic accuracy of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: a meta-analysis. 54 61
20110745 2009
21
Significance of endothelial molecular markers in the evaluation of the severity of acute pancreatitis. 54 61
19319639 2009
22
Activated protein C-protein C inhibitor complex, activation peptide of carboxypeptidase B and C-reactive protein as predictors of severe acute pancreatitis. 54 61
19684435 2009
23
Acute pancreatitis in a girl with panhypopituitarism due to craniopharyngioma on growth hormone treatment. A combination of risk factors. 61 54
19506396 2009
24
Icam-1 and acute pancreatitis complicated by acute lung injury. 61 54
19129609 2009
25
Serum profiles of C-reactive protein, interleukin-8, and tumor necrosis factor-alpha in patients with acute pancreatitis. 61 54
20130823 2009
26
Effect of somatostatin in the prevention of pancreatic complications after endoscopic retrograde cholangiopancreatography. 54 61
19114324 2008
27
[Interleukin 18 (IL-18) and other immunological parameters as markers of severity in acute pancreatitis]. 54 61
19222336 2008
28
[Relationship between acute pancreatitis and systemic inflammation response syndrome in children]. 61 54
19102837 2008
29
Morbimortality indicators in severe acute pancreatitis. 61 54
18981549 2008
30
Molecular basis for pancreatitis. 54 61
19122498 2008
31
Implication of interleukin 18 and intercellular adhesion molecule (ICAM)-1 in acute pancreatitis. 54 61
19102398 2008
32
Therapy for acute pancreatitis with platelet-activating factor receptor antagonists. 61 54
18720532 2008
33
The SPINK1 N34S variant is associated with acute pancreatitis. 54 61
18617776 2008
34
Pancreatitis-associated protein 2 modulates inflammatory responses in macrophages. 54 61
18641332 2008
35
The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats. 61 54
18486906 2008
36
Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice. 54 61
18515422 2008
37
[Acute pancreatitis secondary to hypertriglyceridemia - a report of two cases]. 61 54
18752369 2008
38
Ritonavir and disulfiram may be synergistic in lowering active interleukin-18 levels in acute pancreatitis, and thereby hasten recovery. 54 61
18469453 2008
39
Acute pancreatitis. 61 54
18388680 2008
40
Is there correlation between pancreatic enzyme and radiological severity in acute pancreatitis? 54 61
18416469 2008
41
[Utility of endoscopic ultrasonography in the etiological diagnosis of patients with acute idiopathic pancreatitis]. 54 61
18405484 2008
42
Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. 54 61
18160487 2008
43
Protease activation, pancreatic leakage, and inflammation in acute pancreatitis: differences between mild and severe cases and changes over the first three days. 54 61
18849642 2008
44
TLR and MBL gene polymorphisms in severe acute pancreatitis. 61 54
18288881 2008
45
Monocyte chemoattractant protein 1, active carboxypeptidase B and CAPAP at hospital admission are predictive markers for severe acute pancreatitis. 54 61
18235216 2008
46
Risk factors for recurrent acute alcohol-associated pancreatitis: a prospective analysis. 61 54
18415757 2008
47
[Pancreatitis in pregnant women]. 61 54
18720707 2008
48
Sphincter of Oddi dysfunction and pancreatitis. 54 61
18081221 2007
49
A novel complex deletion-insertion mutation mediated by Alu repetitive elements leads to lipoprotein lipase deficiency. 61 54
17706445 2007
50
Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis. 61 54
17907957 2007

Variations for Acute Pancreatitis

ClinVar genetic disease variations for Acute Pancreatitis:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;XY;t(1;6)(q23;q13)dnTranslocation Uncertain significance 267836

Expression for Acute Pancreatitis

Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for Acute Pancreatitis

Pathways related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.99 MPO IL6 ELANE CXCL8
2 11.67 SST IL6 IL10 CXCL8
3 11.51 IL6 IL10 CXCL8
4 11.27 SCT PNLIP CPB1 CCK
5 11.24 IL6 IL10 CXCL8
6 11.19 IL6 IL10 CXCL8
7 11.11 MPO IL6 ELANE
8 10.28 SCT CCK
9 10.08 IL6 CXCL8 CRP

GO Terms for Acute Pancreatitis

Cellular components related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 SST SPINK1 SCT REG3A PNLIP MPO
2 extracellular space GO:0005615 9.58 SST SPINK1 SCT REG3A PNLIP MPO

Biological processes related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to molecule of bacterial origin GO:0002237 9.43 IL10 CXCL8
2 retinoid metabolic process GO:0001523 9.43 PNLIP LPL APOC2
3 negative regulation of lipid storage GO:0010888 9.4 IL6 CRP
4 very-low-density lipoprotein particle remodeling GO:0034372 9.37 LPL APOC2
5 chylomicron remodeling GO:0034371 9.32 LPL APOC2
6 response to yeast GO:0001878 9.16 MPO ELANE
7 acute-phase response GO:0006953 9.13 REG3A IL6 CRP
8 negative regulation of chemokine biosynthetic process GO:0045079 8.62 IL6 ELANE

Molecular functions related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.02 TMPRSS15 ELANE CTSB CPB1 CPA6

Sources for Acute Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....