MCID: ACT027
MIFTS: 60

Acute Pancreatitis

Categories: Gastrointestinal diseases, Endocrine diseases, Genetic diseases, Rare diseases, Bone diseases, Immune diseases

Aliases & Classifications for Acute Pancreatitis

MalaCards integrated aliases for Acute Pancreatitis:

Name: Acute Pancreatitis 12 76 37 29 55 6 15 63 73
Pancreatitis, Acute Necrotizing 73
Acute Necrotizing Pancreatitis 12
Pancreatitis Necrotizing 12
Necrotizing Pancreatitis 55

Classifications:



External Ids:

Disease Ontology 12 DOID:2913
ICD10 33 K85 K85.9
ICD9CM 35 577.0
NCIt 50 C95437
KEGG 37 H01681

Summaries for Acute Pancreatitis

PubMed Health : 63 About acute pancreatitis: Acute pancreatitis is an inflammation of the pancreas that typically causes very sudden and very severe stomach ache. The most common causes are gallstones and excessive alcohol consumption.Acute pancreatitis can have serious complications, so it is typically treated in the hospital. Most of the time it passes without any serious problems developing in about one to two weeks. But in more severe cases of pancreatitis, treating the complications may take up to several months. Complications of pancreatitis can be fatal.

MalaCards based summary : Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to recurrent acute pancreatitis and hemorrhagic fever with renal syndrome. An important gene associated with Acute Pancreatitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Transcriptional misregulation in cancer. The drugs Acetaminophen and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Acute pancreatitis is a sudden inflammation of the pancreas (pancreatitis). It can have severe... more...

Related Diseases for Acute Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Acute Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 435)
# Related Disease Score Top Affiliating Genes
1 recurrent acute pancreatitis 34.1 LPL SCT SPINK1
2 hemorrhagic fever with renal syndrome 30.9 CRP IL10 IL6
3 dengue hemorrhagic fever 30.8 CXCL8 IL10 IL6
4 gastroenteritis 30.7 CRP CXCL8 IL10 IL6
5 peritonitis 30.6 CRP CXCL8 IL10 IL6 MPO
6 acute cholangitis 30.5 CRP IL6
7 acalculous cholecystitis 30.5 CCK CRP
8 microscopic polyangiitis 30.5 IL10 MPO
9 leptospirosis 30.5 CRP CXCL8 IL10 IL6
10 colitis 30.4 CXCL8 IL10 IL6 MPO
11 polyarteritis nodosa 30.4 CRP IL6 MPO
12 streptococcal toxic-shock syndrome 30.4 CXCL8 IL6
13 aortic aneurysm, familial abdominal, 1 30.4 CRP ELANE IL6
14 cytomegalovirus infection 30.4 CXCL8 IL10 IL6
15 brucellosis 30.3 CRP CXCL8 IL10 IL6
16 meningitis 30.3 CRP CXCL8 IL10 IL6
17 alcoholic hepatitis 30.3 CXCL8 IL10 IL6
18 mouth disease 30.3 CRP IL10 IL6
19 toxic shock syndrome 30.3 CXCL8 IL10 IL6
20 acute respiratory distress syndrome 30.2 CXCL8 ELANE IL6
21 ulcerative colitis 30.2 CRP CXCL8 IL10 IL6 MPO
22 peptic ulcer disease 30.1 CXCL8 IL10 SCT
23 morbid obesity 30.0 CCK CRP LPL
24 arthritis 30.0 CXCL8 IL10 IL18 IL6
25 gallbladder disease 30.0 CCK IL10 SST
26 adult respiratory distress syndrome 30.0 CXCL8 ELANE IL10 IL6
27 visceral leishmaniasis 29.9 CRP CXCL8 IL10 IL18
28 appendicitis 29.7 CRP CXCL8 IL10 IL6 MPO
29 duodenal ulcer 29.7 CCK CXCL8 SCT SST
30 alcoholic pancreatitis 29.4 CCK LPL SCT SPINK1
31 pancreatic agenesis 1 29.4 PNLIP SCT SPINK1
32 pneumonia 29.3 CRP CXCL8 ELANE IL10 IL6 MPO
33 exocrine pancreatic insufficiency 29.1 CCK PNLIP SCT
34 rheumatoid arthritis 29.0 CRP CXCL8 IL10 IL18 IL6 PLA2G2A
35 malaria 28.5 CRP CXCL8 IL10 IL18 IL6
36 cystic fibrosis 28.3 CXCL8 ELANE MPO PNLIP REG3A SCT
37 inflammatory bowel disease 28.2 CRP CXCL8 ELANE IL10 IL18 IL6
38 pancreas disease 28.1 CCK CRP IL6 REG3A SCT SPINK1
39 steatorrhea 27.7 CCK PNLIP SCT SST TMPRSS15
40 pancreatitis 27.7 CCK CPB1 CRP CTSB LPL PLA2G2A
41 cold agglutinin disease 11.0 CRP IL6
42 recurrent corneal erosion 10.9 CXCL8 IL6
43 bagassosis 10.9 CXCL8 IL6
44 hyperlipoproteinemia, type i 10.9
45 pancreatitis, pediatric 10.9
46 eye lymphoma 10.9 IL10 IL6
47 ischemic heart disease 10.9 CRP IL6 LPL
48 cryopyrin-associated periodic syndrome 10.9 CRP IL6
49 multicentric castleman disease 10.9 CRP IL10 IL6
50 tungiasis 10.9 CXCL8 IL10

Comorbidity relations with Acute Pancreatitis via Phenotypic Disease Network (PDN): (show all 39)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Alcohol Abuse Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Atrophic Gastritis Biliary Tract Disease
Biliary Tract Neoplasm Cholangitis
Cholecystitis Cholestasis
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Duodenitis
Esophageal Disease Esophagitis
Gallbladder Disease Heart Disease
Hepatitis Hyperlipoproteinemia, Type Iv
Hypertension, Essential Hypothyroidism
Intestinal Obstruction Iron Deficiency Anemia
Irritable Bowel Syndrome Ischemic Heart Disease
Liver Disease Pancreatic Agenesis 1
Pancreatic Cancer Pancreatitis, Hereditary
Paralytic Ileus Postcholecystectomy Syndrome
Protein-Energy Malnutrition Respiratory Failure
Strawberry Gallbladder

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to Acute Pancreatitis

Symptoms & Phenotypes for Acute Pancreatitis

GenomeRNAi Phenotypes related to Acute Pancreatitis according to GeneCards Suite gene sharing:

26 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.78 CPB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.78 PLA2G6
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.78 SPINK1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.78 MPO
6 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.78 SPINK1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.78 MPO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.78 CPB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.78 PLA2G6
10 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.78 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.78 MPO
12 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.78 PLA2G6
13 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.78 SPINK1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.78 PLA2G6 SPINK1 CPB1 MPO
15 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.78 CPB1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.78 CPB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.78 MPO
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.78 CPB1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.78 MPO
20 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.78 PLA2G6
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.78 SPINK1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.78 MPO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.78 MPO
24 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.78 CPB1 PLA2G6
25 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 CPB1

MGI Mouse Phenotypes related to Acute Pancreatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.83 CRP TMPRSS15 CTSB ELANE IL10 IL18
2 digestive/alimentary MP:0005381 9.7 SST CTSB IL10 IL18 IL6 PNLIP
3 immune system MP:0005387 9.36 CRP TMPRSS15 CTSB ELANE IL10 IL18

Drugs & Therapeutics for Acute Pancreatitis

PubMedHealth treatment related to Acute Pancreatitis: 63

No treatment is available for dealing with the root cause of pancreatitis. But there are a number of options for reducing strain on the pancreas and relieving symptoms. Because fluid levels can drop due to acute pancreatitis, the first step is to prevent dehydration by using infusion therapy. A hollow needle inserted in an arm vein is used to release a solution into the bloodstream. Medication is used to provide relief from pain, nausea and vomiting. Stronger painkillers such as opioids are sometimes needed, and they may make you feel drowsy or light-headed.Solid foods are avoided until the pain recedes and appetite returns to give the pancreas a chance to recuperate. In mild cases of pancreatitis it is sometimes possible to return to eating solid foods after just a few days. If the symptoms last longer, artificial feeding may be necessary to supply your body with enough nutrients.If the pancreatitis is caused by gallstones, the stones may need to be removed using endoscopic retrograde cholangiography. After treatment the gallbladder is surgically removed to prevent further episodes.

Drugs for Acute Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 243)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Clonidine Approved Phase 4 4205-90-7 2803
3 Nefopam Approved, Investigational Phase 4 13669-70-0
4
Ropivacaine Approved Phase 4,Phase 2,Phase 3,Phase 1 84057-95-4 71273 175805
5
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
6
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 3 27203-92-5 33741
7
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185
8
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
9
Meropenem Approved, Investigational Phase 4,Phase 1,Phase 2 119478-56-7 64778 441130
10
Metronidazole Approved Phase 4 443-48-1 4173
11
Somatostatin Approved, Investigational Phase 4,Phase 3,Not Applicable 38916-34-6, 51110-01-1 53481605
12
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
13
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
14
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
15
Indomethacin Approved, Investigational Phase 4,Phase 3,Not Applicable 53-86-1 3715
16
Ketorolac Approved Phase 4,Phase 2,Phase 3 74103-06-3, 66635-83-4 3826
17
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
18
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
19
Protein C Approved Phase 4
20
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
21
Glycerol Approved, Investigational Phase 4,Phase 3 56-81-5 753
22
Zinc Approved, Investigational Phase 4,Phase 3 7440-66-6 23994
23
Azathioprine Approved Phase 4 446-86-6 2265
24
Thioguanine Approved Phase 4 154-42-7 2723601
25
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
26
Serine Approved, Nutraceutical Phase 4,Phase 1 56-45-1 5951
27 Fat Emulsions, Intravenous Phase 4
28 Parenteral Nutrition Solutions Phase 4
29 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Soybean oil, phospholipid emulsion Phase 4
31 Adjuvants, Anesthesia Phase 4,Phase 2,Phase 3,Phase 1
32 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Analgesics, Opioid Phase 4,Phase 2,Phase 3,Phase 1
35 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Anesthetics, General Phase 4,Phase 2,Phase 3,Phase 1
37 Anesthetics, Intravenous Phase 4,Phase 2,Phase 3,Phase 1
38 Anesthetics, Local Phase 4,Phase 2,Phase 3,Not Applicable
39 Antipyretics Phase 4
40 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Narcotics Phase 4,Phase 2,Phase 3,Phase 1
42 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
46 Anti-Infective Agents, Local Phase 4
47 Antiparasitic Agents Phase 4
48 Antiprotozoal Agents Phase 4
49 Chlorhexidine gluconate Phase 4
50 Dermatologic Agents Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 211)
# Name Status NCT ID Phase Drugs
1 Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
2 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
3 Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
4 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
5 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis Unknown status NCT02691598 Phase 4 Infusion
6 Imipenem Prophylaxis in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
7 Activated Protein C in Severe Acute Pancreatitis Completed NCT01017107 Phase 4 Activated protein C
8 Enteral Nutrition in Acute Pancreatitis Completed NCT01965873 Phase 4
9 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
10 Acute Pancreatitis and Acute Fluid Collections Completed NCT00786929 Phase 4 Conservative treatment
11 Early Enteral Nutrition for Severe Acute Pancreatitis Completed NCT00995098 Phase 4
12 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
13 A Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
14 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
15 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
16 To Study the Effects of Lipid Emulsion on Hemodynamics in Organophosphate Compound Poisoning Completed NCT03564574 Phase 4
17 Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial Completed NCT02517476 Phase 4
18 Treatment of Acute Pancreatitis With Ketorolac Recruiting NCT02885441 Phase 4 Ketorolac;Placebo
19 Thiopurine Induced Pancreatitis in IBD Patients Recruiting NCT02281799 Phase 4 Azathioprine
20 Rectal Indomethacin to Prevent Post ESWL-pancreatitis Recruiting NCT02797067 Phase 4 indomethacin suppository;glycerin suppository
21 Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis. Not yet recruiting NCT03501680 Phase 4 Insulin
22 Oral Resveratrol to Prevent Post-ERCP Pancreatitis Not yet recruiting NCT02947932 Phase 4 Resveratrol;Indomethacin
23 Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis Not yet recruiting NCT03342807 Phase 4 Insulin
24 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal Not yet recruiting NCT03082469 Phase 4
25 COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis Not yet recruiting NCT02964403 Phase 4 Cox-2;Indomethacin
26 Ulinastatin in Severe Acute Pancreatitis Suspended NCT01132521 Phase 4 ulinastatin;placebo
27 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
28 Epidural Anesthesia in Acute Pancreatitis Unknown status NCT02617199 Phase 2, Phase 3 Epidural anesthesia;intravenous analgesia
29 Evaluation of Effect of Integrated Treatment by Traditional Chinese and Western Medicine for Severe Acute Pancreatitis Unknown status NCT00506337 Phase 2, Phase 3 Qingyi granules
30 Efficacy of Administration of Somatostatin in the Prevention of Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis Unknown status NCT01060826 Phase 3 somatostatin, intravenous bolus;somatostatin
31 Effect of Traditional Chinese Medicine on GI Function Recovery and Nutrition Support in SAP Unknown status NCT00508729 Phase 2, Phase 3 Qingyi granules
32 Safety and Efficacy in LPL-Deficient Subjects of AMT-011, an Adeno-Associated Viral Vector Expressing Human Lipoprotein Lipase [S447X] Unknown status NCT01109498 Phase 2, Phase 3 Mycophenolate mofetil;cyclosporine
33 MIld to MOderate Acute Pancreatitis: Early naSogastric Tube Feeding Compared With pAncreas Rest (MIMOSA) Completed NCT01128478 Phase 2, Phase 3
34 Indomethacin Decreases Post-ERCP Pancreatitis Completed NCT02110810 Phase 3 Indomethacin;2.6-g suppository of glycerin
35 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
36 Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis Completed NCT01977118 Phase 2, Phase 3 streptokinase
37 Lactated Ringers With or Without Rectal Indomethacin to Prevent Post-ERCP Pancreatitis Completed NCT02641561 Phase 3 Indomethacin;Lactated Ringer's Solution;Normal Saline;Placebo
38 Does Glyceryl Nitrate Prevent Post-Endoscopic Retrograde Cholangiopancreaticography (ERCP) Pancreatitis? Completed NCT00121901 Phase 3 glyceryl nitrate
39 Effects of Delayed Enteral Nutrition on Inflammatory Responses and Immune Function Competence in Critically Ill Patients With Prolonged Fasting Completed NCT01834430 Phase 3
40 Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis Completed NCT00523341 Phase 3
41 A Prospective Validation Study of Albumin Kinetics With Tracer 123 I-HSA Completed NCT01686776 Phase 3
42 A Study of Dulaglutide (LY2189265) in Participants With Type II Diabetes Completed NCT02152371 Phase 3 Dulaglutide;Placebo;Insulin Glargine;Metformin
43 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
44 A Study of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes Mellitus Completed NCT02597049 Phase 3 Dulaglutide;Placebo;SGLT2 inhibitor;Metformin
45 Study of How Dulaglutide Compares to Placebo in Participants With Type 2 Diabetes Who Are Also on Sulfonylurea Therapy (AWARD-8) Completed NCT01769378 Phase 3 Placebo;Dulaglutide;Glimepiride
46 A Study Comparing the Effect of Dulaglutide With Liraglutide in Type 2 Diabetes Completed NCT01624259 Phase 3 LY2189265;Liraglutide;Metformin
47 Safety and Efficacy of Linagliptin (BI 1356) as Monotherapy or in Combination in Type 2 DM Completed NCT00736099 Phase 3 linagliptine 5 mg;linagliptine 5 mg and pioglitazone 30 mg
48 A Trial of Indomethacin in Acute Pancreatitis Recruiting NCT03547232 Phase 3 Indomethacin SR;Placebos
49 A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis Recruiting NCT02692391 Phase 3 Indomethacin;Placebo
50 Fluid Resuscitation in Acute Pancreatitis Recruiting NCT02709044 Phase 2, Phase 3 Ringer lactate

Search NIH Clinical Center for Acute Pancreatitis

Genetic Tests for Acute Pancreatitis

Genetic tests related to Acute Pancreatitis:

# Genetic test Affiliating Genes
1 Acute Pancreatitis 29

Anatomical Context for Acute Pancreatitis

MalaCards organs/tissues related to Acute Pancreatitis:

41
Pancreas, Liver, Lung, Neutrophil, Testes, Kidney, Monocytes

Publications for Acute Pancreatitis

Articles related to Acute Pancreatitis:

(show top 50) (show all 1841)
# Title Authors Year
1
A Tale of Three Tails and a Cystic Lesion: A Rare Cause of Recurrent Acute Pancreatitis. ( 29961770 )
2018
2
Myxedema Coma Following the Administration of Gonadotropin-releasing Hormone Agonist Complicated by Acute Pancreatitis. ( 29877268 )
2018
3
Cerulein-Induced Acute Pancreatitis Affects Sphingomyelin Signaling Pathway in Rats. ( 29939906 )
2018
4
Pancreaticopleural fistula associated with choledocholithiasis: An infrequent complication of acute pancreatitis. ( 29530342 )
2018
5
Secondary Hypertriglyceridemia Causing Recurrent Acute Pancreatitis with Normal Pancreatic Enzymes. ( 29910554 )
2018
6
Recurrent Acute Pancreatitis in Children: Do not forget the "Worms". ( 29095350 )
2018
7
Acute Pancreatitis and Pancreatic Cancer Risk: A Nationwide Matched-cohort Study in Denmark. ( 29432727 )
2018
8
Management of acute pancreatitis in the first 72 hours. ( 29957661 )
2018
9
Acute pancreatitis: ascaris in the pancreatic duct. ( 29452432 )
2018
10
Intraductal tubulopapillary neoplasm of the pancreas presenting as recurrent acute pancreatitis: A case report. ( 29906691 )
2018
11
Cav 1.2 and Cav 2.2 expression is regulated by different endogenous ghrelin levels in pancreatic acinar cells during acute pancreatitis. ( 29436604 )
2018
12
Therapeutic effect of Bifidobacterium combined with early enteral nutrition in the treatment of severe acute pancreatitis: a pilot study. ( 29949178 )
2018
13
Trimethoprim-sulfamethoxazole induces acute pancreatitis associated with drug-specific cytotoxic T lymphocytes. ( 29940316 )
2018
14
Pediatric case of generalized pustular psoriasis developing acute pancreatitis. ( 29655246 )
2018
15
Pathophysiology and nursing management of acute pancreatitis. ( 29952150 )
2018
16
Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice. ( 29971769 )
2018
17
Colopancreatic Fistula: An Uncommon Complication of Recurrent Acute Pancreatitis. ( 29785309 )
2018
18
Total pancreatectomy and islet autotransplantion for chronic and recurrent acute pancreatitis. ( 29901515 )
2018
19
Late onset acute pancreatitis in <i>P. falciparum</i> malaria - An adverse reaction to intravenous artesunate? ( 29942768 )
2018
20
Endoscopic diagnosis and treatment of biliary obstruction due to acute cholangitis and acute pancreatitis secondary to Fasciola hepatica infection. ( 29350372 )
2018
21
Severe Acute Pancreatitis as an Index Clinical Manifestation of Parathyroid Adenoma. ( 29888149 )
2018
22
Lemierre's syndrome presented with acute pancreatitis. ( 29657730 )
2018
23
Neutrophil-lymphocyte ratio, gamma-glutamyl transpeptidase, lipase, high-density lipoprotein as a panel of factors to predict acute pancreatitis in pregnancy. ( 29952970 )
2018
24
Etiology Is Linked to the Length of Admission in Patients With Acute Pancreatitis: Is Novel Endoscopy an Unrecognized Cause? ( 29424812 )
2018
25
Acute pancreatitis during GLP-1 receptor agonist treatment. A case report. ( 29440961 )
2018
26
Role of thrombophilia in splanchnic venous thrombosis in acute pancreatitis. ( 29720864 )
2018
27
Fluid resuscitation with lactated Ringer's solution vs normal saline in acute pancreatitis: A triple-blind, randomized, controlled trial. ( 29435315 )
2018
28
Gastrointestinal: Recurrent acute pancreatitis with a large fluid collection: Pseudocyst or else? ( 29659085 )
2018
29
Acute Pancreatitis in a Patient with Maple Syrup Urine Disease: A Management Paradox. ( 29681447 )
2018
30
Resolvin D1 Resolve Inflammation in Experimental Acute Pancreatitis by Restoring Autophagic Flux. ( 29974378 )
2018
31
Serum Osteopontin Is Associated With Organ Failure in Patients With Acute Pancreatitis. ( 29424811 )
2018
32
Red cell distribution width and red cell distribution width to total serum calcium ratio as major predictors of severity and mortality in acute pancreatitis. ( 29976140 )
2018
33
Ultrasonic/CT image fusion guidance facilitating percutaneous catheter drainage in treatment of acute pancreatitis complicated with infected walled-off necrosis. ( 29954676 )
2018
34
Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis. ( 29867178 )
2018
35
A Clinical Model for the Early Diagnosis of Acute Pancreatitis in the Emergency Department. ( 29975351 )
2018
36
THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE. ( 29947686 )
2018
37
Hepatobiliary and Pancreatic: Segmental arterial mediolysis of pancreaticoduodenal artery accompanied by acute pancreatitis and duodenal obstruction. ( 29691909 )
2018
38
Correction:<i>Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol</i>. ( 29440166 )
2018
39
Acquisition of tolerance to egg allergy in a child with repeated egg-induced acute pancreatitis. ( 29754972 )
2018
40
What may cause fetus loss from acute pancreatitis in pregnancy: Analysis of 54 cases. ( 29443736 )
2018
41
Coil embolization using microballoon assistance combined with the double-catheter technique for a large superior mesenteric arterial pseudoaneurysm and fistula secondary to acute pancreatitis. ( 29942908 )
2018
42
Single Nucleotide Polymorphisms in the Vitamin D Receptor Gene (<i>VDR</i>) May Have an Impact on Acute Pancreatitis (AP) Development: A Prospective Study in Populations of AP Patients and Alcohol-Abuse Controls. ( 29966312 )
2018
43
Recurrent Acute Pancreatitis: International State-of-the-Science Conference With Recommendations. ( 29894415 )
2018
44
Hepatic infarction and acute pancreatitis: a case report and review of the literature. ( 29594198 )
2018
45
Compound but non-linked heterozygous p.W14X and p.L279A V LPL gene mutations in a Chinese patient with long-term severe hypertriglyceridemia and recurrent acute pancreatitis. ( 29921298 )
2018
46
Acute pancreatitis as the first manifestation in a young boy with primary hyperparathyroidism. ( 29704155 )
2018
47
Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha level by lycopene is comparable to methylprednisolone in acute pancreatitis. ( 29439880 )
2018
48
Autophagy Strengthens Intestinal Mucosal Barrier by Attenuating Oxidative Stress in Severe Acute Pancreatitis. ( 29427225 )
2018
49
Safety and efficacy of total parenteral nutrition versus total enteral nutrition for patients with severe acute pancreatitis: a meta-analysis. ( 29962261 )
2018
50
MiRNA-155 Regulates the Th17/Treg Ratio by Targeting SOCS1 in Severe Acute Pancreatitis. ( 29937734 )
2018

Variations for Acute Pancreatitis

ClinVar genetic disease variations for Acute Pancreatitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XY;t(1;6)(q23;q13)dn Translocation Uncertain significance

Expression for Acute Pancreatitis

Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for Acute Pancreatitis

GO Terms for Acute Pancreatitis

Cellular components related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 CCK CPB1 CRP CTSB CXCL8 ELANE
2 extracellular space GO:0005615 9.58 CCK CPB1 CRP CTSB CXCL8 ELANE
3 secretory granule GO:0030141 9.33 ELANE MPO PLA2G2A

Biological processes related to Acute Pancreatitis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.81 CXCL8 ELANE IL10 MPO
2 defense response to Gram-positive bacterium GO:0050830 9.75 CRP IL6 PLA2G2A
3 inflammatory response GO:0006954 9.73 CRP CXCL8 IL10 IL18 IL6 REG3A
4 positive regulation of inflammatory response GO:0050729 9.71 IL18 LPL PLA2G2A
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.67 ELANE IL18 IL6
6 antimicrobial humoral response GO:0019730 9.65 ELANE PLA2G2A REG3A
7 lipid catabolic process GO:0016042 9.62 LPL PLA2G2A PLA2G6 PNLIP
8 acute-phase response GO:0006953 9.58 CRP IL6 REG3A
9 response to molecule of bacterial origin GO:0002237 9.57 CXCL8 IL10
10 low-density lipoprotein particle remodeling GO:0034374 9.56 MPO PLA2G2A
11 neutrophil activation GO:0042119 9.55 CXCL8 IL18
12 negative regulation of lipid storage GO:0010888 9.52 CRP IL6
13 type 2 immune response GO:0042092 9.46 IL10 IL18
14 response to yeast GO:0001878 9.43 ELANE MPO
15 negative regulation of chemokine biosynthetic process GO:0045079 9.37 ELANE IL6
16 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.33 IL18 LPL PLA2G2A
17 regulation of signaling receptor activity GO:0010469 9.17 CCK CXCL8 IL10 IL18 IL6 SCT
18 negative regulation of growth of symbiont in host GO:0044130 9.13 ELANE IL10 MPO

Molecular functions related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.56 CPB1 CTSB ELANE LPL PLA2G2A PLA2G6
2 cytokine activity GO:0005125 8.92 CXCL8 IL10 IL18 IL6

Sources for Acute Pancreatitis

3 CDC
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10 dbSNP
11 DGIdb
17 ExPASy
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28 GO
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