MCID: ACT176
MIFTS: 26

Acute Panmyelosis with Myelofibrosis

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Acute Panmyelosis with Myelofibrosis

MalaCards integrated aliases for Acute Panmyelosis with Myelofibrosis:

Name: Acute Panmyelosis with Myelofibrosis 52 58 71 32
Acute Myelodysplasia with Myelofibrosis 52 58
Acute Myelosclerosis 52 58
Acute Myelofibrosis 52 58

Characteristics:

Orphanet epidemiological data:

58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 32 C94.4
ICD10 via Orphanet 33 C94.4
UMLS via Orphanet 72 C0334674
Orphanet 58 ORPHA86843
UMLS 71 C0334674

Summaries for Acute Panmyelosis with Myelofibrosis

MalaCards based summary : Acute Panmyelosis with Myelofibrosis, also known as acute myelodysplasia with myelofibrosis, is related to megakaryocytic leukemia and myelofibrosis, and has symptoms including fatigue Affiliated tissues include bone, bone marrow and myeloid, and related phenotypes are pancytopenia and myelofibrosis

Wikipedia : 74 Acute panmyelosis with myelofibrosis (APMF) it is a poorly defined disorder that arises as either a... more...

Related Diseases for Acute Panmyelosis with Myelofibrosis

Diseases related to Acute Panmyelosis with Myelofibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 megakaryocytic leukemia 11.9
2 myelofibrosis 10.8
3 leukemia, acute myeloid 10.6
4 pancytopenia 10.6
5 splenomegaly 10.6
6 myelodysplastic syndrome 10.5
7 myeloid leukemia 10.5
8 leukemia 10.2
9 acute leukemia 10.2
10 leukemia, acute lymphoblastic 10.1
11 lymphocytic leukemia 10.1
12 myeloproliferative neoplasm 10.1
13 refractory anemia 10.0
14 lymphoma 10.0
15 monocytic leukemia 9.9
16 sideroblastic anemia 9.9
17 chromosomal triplication 9.9
18 erythroleukemia, familial 9.8
19 esophageal cancer 9.8
20 leukemia, acute monocytic 9.8
21 scleroderma, familial progressive 9.8
22 myeloma, multiple 9.8
23 werner syndrome 9.8
24 thrombocytopenia 6 9.8
25 deficiency anemia 9.8
26 hyperphosphatemia 9.8
27 bacterial infectious disease 9.8
28 neutropenia 9.8
29 thrombocytopenia 9.8
30 kidney cancer 9.8
31 purpura 9.8
32 systemic scleroderma 9.8
33 plasma cell neoplasm 9.8
34 47,xyy 9.8
35 acute monoblastic leukemia 9.8
36 cytokine deficiency 9.8
37 granulocytopenia 9.8
38 trisomy 1q 9.8
39 large granular lymphocyte leukemia 9.8

Graphical network of the top 20 diseases related to Acute Panmyelosis with Myelofibrosis:



Diseases related to Acute Panmyelosis with Myelofibrosis

Symptoms & Phenotypes for Acute Panmyelosis with Myelofibrosis

Human phenotypes related to Acute Panmyelosis with Myelofibrosis:

58 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pancytopenia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001876
2 myelofibrosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0011974
3 muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0001324
4 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
5 bone marrow hypercellularity 58 31 frequent (33%) Frequent (79-30%) HP:0031020
6 abnormality of bone marrow stromal cells 58 31 frequent (33%) Frequent (79-30%) HP:0012129
7 bone marrow hypocellularity 58 31 occasional (7.5%) Occasional (29-5%) HP:0005528
8 acute myeloid leukemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0004808
9 lymphocytosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100827
10 acute myelomonocytic leukemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0004820
11 low back pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0003419
12 megakaryocyte nucleus hypolobulation 58 31 occasional (7.5%) Occasional (29-5%) HP:0031385
13 increased micromegakaryocyte count 58 31 occasional (7.5%) Occasional (29-5%) HP:0031386
14 splenomegaly 58 31 very rare (1%) Very rare (<4-1%) HP:0001744
15 abnormal megakaryocyte morphology 58 Frequent (79-30%)

UMLS symptoms related to Acute Panmyelosis with Myelofibrosis:


fatigue

Drugs & Therapeutics for Acute Panmyelosis with Myelofibrosis

Search Clinical Trials , NIH Clinical Center for Acute Panmyelosis with Myelofibrosis

Genetic Tests for Acute Panmyelosis with Myelofibrosis

Anatomical Context for Acute Panmyelosis with Myelofibrosis

MalaCards organs/tissues related to Acute Panmyelosis with Myelofibrosis:

40
Bone, Bone Marrow, Myeloid, Monocytes, Kidney

Publications for Acute Panmyelosis with Myelofibrosis

Articles related to Acute Panmyelosis with Myelofibrosis:

(show all 32)
# Title Authors PMID Year
1
TP53 abnormalities and chromosomal aneuploidy in acute panmyelosis with myelofibrosis. 61
31350530 2019
2
Hematopoietic Cell Transplantation for Acute Panmyelosis with Myelofibrosis: A Retrospective Study in Japan. 61
30103016 2019
3
Incidence, Survival, and Risk Factors for Adults with Acute Myeloid Leukemia Not Otherwise Specified and Acute Myeloid Leukemia with Recurrent Genetic Abnormalities: Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database, 2001-2013. 61
29455198 2018
4
AML with myelodysplasia-related changes masquerades as acute panmyelosis with myelofibrosis. 61
29025719 2017
5
CALR, JAK2, and MPL mutation profiles in patients with four different subtypes of myeloproliferative neoplasms: primary myelofibrosis, essential thrombocythemia, polycythemia vera, and myeloproliferative neoplasm, unclassifiable. 61
25873496 2015
6
S100 expression by atypical megakaryocytes: a previously unreported potential pitfall in dermatopathology. 61
25371084 2014
7
Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice. 61
25148222 2014
8
Differential diagnosis of myelofibrosis based on WHO 2008 criteria: acute panmyelosis with myelofibrosis, acute megakaryoblastic leukemia with myelofibrosis, primary myelofibrosis and myelodysplastic syndrome with myelofibrosis. 61
23693053 2013
9
[Acute panmyelosis with myelofibrosis: a rare cause of pancytopenia]. 61
24192103 2013
10
Acute panmyelosis with myelofibrosis - a rare subtype of acute myeloid leukemia. 61
23795280 2013
11
Acute panmyelosis with myelofibrosis with EVI1 amplification. 61
22682625 2012
12
Successful control of acute myelofibrosis with lenalidomide. 61
21274282 2010
13
Myelodysplastic syndromes. 61
19605823 2009
14
Histopathology in the diagnosis and classification of acute myeloid leukemia, myelodysplastic syndromes, and myelodysplastic/myeloproliferative diseases. 61
17587881 2007
15
Long-term follow-up of autologous peripheral blood stem cell transplantation in the treatment of a patient with acute panmyelosis with myelofibrosis. 61
17194659 2006
16
Peritoneal haematopoiesis in acute panmyelosis with myelofibrosis. 61
15982337 2005
17
Acute panmyelosis with myelofibrosis: an entity distinct from acute megakaryoblastic leukemia. 61
15578075 2005
18
Acute panmyelosis with myelofibrosis: clinical, immunophenotypic and cytogenetic study of twelve cases. 61
15223649 2004
19
Zoledronate-induced remission of acute panmyelosis with myelofibrosis. 61
15287920 2004
20
Acute panmyelosis with myelofibrosis: a clinicopathological study on 46 patients including histochemistry of bone marrow biopsies and follow-up. 61
15173958 2004
21
Acute panmyelosis with myelofibrosis. 61
15160939 2004
22
Acute myelosclerosis--morphological and clinical analysis of the case. A review of literature. 61
1283783 1992
23
Malignant (acute) myelosclerosis--a case report. 61
3454638 1987
24
Idiopathic acquired sideroblastic anaemia transforming to acute myelosclerosis. 61
6470180 1984
25
Malignant (acute) myelosclerosis--a clinical and pathological study in 6 patients. 61
6611583 1984
26
[Acute myelosclerosis. Evolution in acute lymphoblastic leukemia]. 61
6428996 1984
27
Symposium: classification of leukemia. 1. The classification of acute leukemia. 61
6290966 1982
28
Idiopathic acquired sideroblastic anemia terminating in acute myelosclerosis. 61
7074567 1982
29
Leukaemia of platelet precursors: diverse features in four cases. 61
7200369 1982
30
Bone marrow transplantation for acute myelosclerosis. 61
7028243 1981
31
Acute myelosclerosis after treatment for non-Hodgkin's lymphoma. 61
7436177 1980
32
Acute ("malignant") myelosclerosis. 61
367569 1979

Variations for Acute Panmyelosis with Myelofibrosis

Expression for Acute Panmyelosis with Myelofibrosis

Search GEO for disease gene expression data for Acute Panmyelosis with Myelofibrosis.

Pathways for Acute Panmyelosis with Myelofibrosis

GO Terms for Acute Panmyelosis with Myelofibrosis

Sources for Acute Panmyelosis with Myelofibrosis

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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