MCID: ACT040
MIFTS: 37

Acute Poststreptococcal Glomerulonephritis

Categories: Nephrological diseases

Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

MalaCards integrated aliases for Acute Poststreptococcal Glomerulonephritis:

Name: Acute Poststreptococcal Glomerulonephritis 12 55 15
Acute Post-Streptococcal Glomerulonephritis 73
Post-Streptococcal Glomerulonephritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14064
NCIt 50 C35443
SNOMED-CT 68 68544003
UMLS 73 C0403414

Summaries for Acute Poststreptococcal Glomerulonephritis

MalaCards based summary : Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to mesangial proliferative glomerulonephritis and rapidly progressive glomerulonephritis. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (Complement Factor Properdin), and among its related pathways/superpathways are Immune response Lectin induced complement pathway and Staphylococcus aureus infection. The drugs Antistreptolysin and Complement System Proteins have been mentioned in the context of this disorder. Affiliated tissues include monocytes, skin and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Acute Poststreptococcal Glomerulonephritis

Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 mesangial proliferative glomerulonephritis 30.2 CD79A EDN1
2 rapidly progressive glomerulonephritis 30.2 C5 CD79A
3 membranoproliferative glomerulonephritis 30.0 CD79A CFP
4 acute proliferative glomerulonephritis 11.4
5 glomerulonephritis 10.9
6 complement component 5 deficiency 10.6 C5 CFP
7 complement deficiency 10.5 C5 CFP
8 hepatic vascular disease 10.5 EDN1 PLG
9 intestinal impaction 10.4 PLG SERPINF2
10 cerebral arteritis 10.4 CD79A PLG
11 diffuse glomerulonephritis 10.4 CD79A CFP
12 alpha-2-plasmin inhibitor deficiency 10.4 PLG SERPINF2
13 malignant hypertension 10.4 EDN1 NPPA
14 giant hemangioma 10.4 PLG SERPINF2
15 intracranial embolism 10.4 PLG SERPINF2
16 idiopathic edema 10.4 EDN1 NPPA
17 osteosclerotic myeloma 10.4 CD79A PLG
18 acute cor pulmonale 10.4 PLG SERPINF2
19 hepatorenal syndrome 10.4 EDN1 NPPA
20 acute pulmonary heart disease 10.3 PLG SERPINF2
21 angina pectoris 10.3 EDN1 SERPINF2
22 conjunctival disease 10.3 CD79A PLG
23 cicatricial pemphigoid 10.3 CD79A CFP
24 rheumatic fever-related antigen 10.3
25 rheumatic fever 10.3
26 renovascular hypertension 10.3 EDN1 NPPA
27 acute articular rheumatism 10.3
28 rubeosis iridis 10.2 PLG SERPINF2
29 nodular nonsuppurative panniculitis 10.2 CFP SERPINF2
30 idiopathic hypercalciuria 10.2 EDN1 NPPA
31 impetigo 10.1
32 encephalopathy 10.1
33 gingival disease 10.1 CD79A SERPINF2
34 thrombophilia due to activated protein c resistance 10.0 PLG SERPINF2
35 perinephritis 10.0 EDN1 EDNRB
36 rheumatoid arthritis 10.0
37 arthritis 10.0
38 purpura 10.0
39 hypertensive encephalopathy 10.0
40 diffuse alveolar hemorrhage 10.0
41 korean hemorrhagic fever 9.9 NPPA PLG SERPINF2
42 obstructive jaundice 9.9 CD79A EDN1
43 bardet-biedl syndrome 2 9.9
44 bardet-biedl syndrome 10 9.9
45 bardet-biedl syndrome 11 9.9
46 bardet-biedl syndrome 12 9.9
47 cerebral hemorrhage 9.9
48 thrombocytopenia 9.9
49 interstitial nephritis 9.9
50 nephrotic syndrome 9.9

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to Acute Poststreptococcal Glomerulonephritis

Symptoms & Phenotypes for Acute Poststreptococcal Glomerulonephritis

MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 C5 CFP EDN1 EDNRB NPPA PLG
2 homeostasis/metabolism MP:0005376 9.56 C5 CD79A CFP EDN1 EDNRB NPPA
3 renal/urinary system MP:0005367 9.1 C5 CD79A EDN1 EDNRB NPPA PLG

Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

Drugs for Acute Poststreptococcal Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antistreptolysin
2 Complement System Proteins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hospital Based Incidence of Group A Streptococcal Disease in Fiji Completed NCT00264771
2 Acute Post Streptococcal Glomerulonephritis Not yet recruiting NCT03184103

Search NIH Clinical Center for Acute Poststreptococcal Glomerulonephritis

Genetic Tests for Acute Poststreptococcal Glomerulonephritis

Anatomical Context for Acute Poststreptococcal Glomerulonephritis

MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

41
Monocytes, Skin, Brain, Spleen

Publications for Acute Poststreptococcal Glomerulonephritis

Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50) (show all 131)
# Title Authors Year
1
Posterior Reversible Encephalopathy Syndrome Secondary to Acute PostStreptococcal Glomerulonephritis in a 12-year-old Girl. ( 29290203 )
2018
2
Cardiac status in children with acute poststreptococcal glomerulonephritis. ( 28748885 )
2017
3
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: An uncommon coincidence. ( 27625530 )
2016
4
IgA-dominant acute poststreptococcal glomerulonephritis with concomitant rheumatic fever successfully treated with steroids: a case report. ( 26718763 )
2015
5
Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis. ( 25554106 )
2015
6
Diffuse alveolar hemorrhage in a patient with acute poststreptococcal glomerulonephritis caused by impetigo. ( 25876581 )
2015
7
Diffuse alveolar hemorrhage as a presentation of acute poststreptococcal glomerulonephritis. ( 24927907 )
2014
8
Acute poststreptococcal glomerulonephritis with acute interstitial nephritis related to streptococcal pyrogenic exotoxin B. ( 26064502 )
2013
9
Acute poststreptococcal glomerulonephritis: a manifestation of immune reconstitution inflammatory syndrome. ( 22891230 )
2012
10
Acute reversible changes of brachial-ankle pulse wave velocity in children with acute poststreptococcal glomerulonephritis. ( 20640906 )
2011
11
Unfavorable outcome in a child with megaureter-megacystis syndrome complicated by mild acute poststreptococcal glomerulonephritis. ( 21166952 )
2010
12
Localization of nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis. ( 20708459 )
2010
13
Evidence-based treatment limitations prevent any therapeutic recommendation for acute poststreptococcal glomerulonephritis in children. ( 20357732 )
2010
14
Elevated plasma levels of N-terminal pro-brain natriuretic peptide in children with acute poststreptococcal glomerulonephritis. ( 19346734 )
2009
15
Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis. ( 19095947 )
2009
16
Elevated urinary plasmin activity resistant to alpha2-antiplasmin in acute poststreptococcal glomerulonephritis. ( 18223261 )
2008
17
Acute poststreptococcal glomerulonephritis: an update. ( 18332711 )
2008
18
Acute poststreptococcal glomerulonephritis superimposed on IgA nephropathy. ( 18793531 )
2008
19
Sequence and expression of NAPlr is conserved among group A streptococci isolated from patients with acute poststreptococcal glomerulonephritis (APSGN) and non-APSGN. ( 17557271 )
2007
20
Antibodies against four proteins from a Streptococcus pyogenes serotype M1 strain and levels of circulating mannan-binding lectin in acute poststreptococcal glomerulonephritis. ( 16508336 )
2006
21
Nephritogenic antigen for acute poststreptococcal glomerulonephritis. ( 16518356 )
2006
22
An adult with acute poststreptococcal glomerulonephritis complicated by hemolytic uremic syndrome and nephrotic syndrome. ( 16183409 )
2005
23
Glomerular plasmin-like activity in relation to nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis. ( 15574512 )
2005
24
Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response. ( 15213266 )
2004
25
Monocyte chemoattractant protein-1 and interleukin-8 levels in children with acute poststreptococcal glomerulonephritis. ( 15206029 )
2004
26
Thrombocytopenia during the course of acute poststreptococcal glomerulonephritis. ( 12921303 )
2003
27
Acute poststreptococcal glomerulonephritis and acute rheumatic fever in the same patient: a case report and review of the literature. ( 12967898 )
2003
28
Acute poststreptococcal glomerulonephritis mimicking Henoch-SchAPnlein purpura. ( 12572934 )
2003
29
Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension. ( 12654066 )
2003
30
Acute poststreptococcal glomerulonephritis in a child with Bardet-Biedl syndrome. ( 11793138 )
2002
31
Another case of acute poststreptococcal glomerulonephritis with recurrence. ( 12162274 )
2002
32
Prognosis of acute poststreptococcal glomerulonephritis (APSGN) is excellent in children, when adequately diagnosed. ( 11472580 )
2001
33
Acute poststreptococcal glomerulonephritis: public health implications of recent clusters in New South Wales and epidemiology of hospital admissions. ( 11467793 )
2001
34
Recurrence of acute poststreptococcal glomerulonephritis. ( 11465811 )
2001
35
Acute poststreptococcal glomerulonephritis following circumcision. ( 11149125 )
2000
36
Acute poststreptococcal glomerulonephritis associated with thrombotic microangiopathy in an adult. ( 10968697 )
2000
37
The potential role for nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis. ( 10816380 )
2000
38
Frequency of microscopic hematuria in acute poststreptococcal glomerulonephritis. ( 10353421 )
1999
39
Anticardiolipin antibodies in acute poststreptococcal glomerulonephritis and streptococcal impetigo. ( 10461035 )
1999
40
Renal function during and after childhood acute poststreptococcal glomerulonephritis. ( 10603146 )
1999
41
Evaluating the use of penicillin to control outbreaks of acute poststreptococcal glomerulonephritis. ( 10223684 )
1999
42
Acute poststreptococcal glomerulonephritis presenting with hemoptysis. ( 9686966 )
1998
43
C3 mesangial proliferative glomerulonephritis--an evaluation of acute poststreptococcal glomerulonephritis? ( 9518184 )
1997
44
Acute poststreptococcal glomerulonephritis in children. ( 9331614 )
1997
45
Searching for acute poststreptococcal glomerulonephritis-associated Streptococcus pyogenes in Australian aboriginal communities. ( 9331610 )
1997
46
Renal functional reserve after acute poststreptococcal glomerulonephritis. ( 9260248 )
1997
47
Asymptomatic acute poststreptococcal glomerulonephritis following upper respiratory tract infections caused by Group A streptococci. ( 8953117 )
1996
48
An experimental model for acute poststreptococcal glomerulonephritis in mice. ( 8982244 )
1996
49
Renal hydatid cyst detected in a child during the course of acute poststreptococcal glomerulonephritis. ( 7723915 )
1995
50
Myocardial dysfunction in a 23-month child with acute poststreptococcal glomerulonephritis. ( 7793601 )
1995

Variations for Acute Poststreptococcal Glomerulonephritis

Expression for Acute Poststreptococcal Glomerulonephritis

Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.

Pathways for Acute Poststreptococcal Glomerulonephritis

GO Terms for Acute Poststreptococcal Glomerulonephritis

Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 C4BPA C5 CFP EDN1 NPPA PLG
2 blood microparticle GO:0072562 9.33 C4BPA PLG SERPINF2
3 platelet alpha granule lumen GO:0031093 9.26 PLG SERPINF2
4 extracellular space GO:0005615 9.17 C4BPA C5 CFP EDN1 NPPA PLG

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.62 C5 CD79A EDN1 EDNRB
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.6 EDN1 SERPINF2
3 calcium-mediated signaling GO:0019722 9.59 EDN1 EDNRB
4 sensory perception of pain GO:0019233 9.58 EDN1 EDNRB
5 regulation of sensory perception of pain GO:0051930 9.58 EDN1 EDNRB
6 regulation of complement activation GO:0030449 9.58 C4BPA C5 CFP
7 blood vessel morphogenesis GO:0048514 9.57 EDN1 SERPINF2
8 positive regulation of heart rate GO:0010460 9.56 EDN1 NPPA
9 fibrinolysis GO:0042730 9.55 PLG SERPINF2
10 regulation of pH GO:0006885 9.54 EDN1 EDNRB
11 regulation of blood vessel size GO:0050880 9.52 EDN1 NPPA
12 vasoconstriction GO:0042310 9.51 EDN1 EDNRB
13 response to muscle stretch GO:0035994 9.49 EDN1 NPPA
14 positive regulation of renal sodium excretion GO:0035815 9.48 EDN1 EDNRB
15 positive regulation of urine volume GO:0035810 9.46 EDN1 EDNRB
16 complement activation, alternative pathway GO:0006957 9.43 C5 CFP
17 negative regulation of fibrinolysis GO:0051918 9.37 PLG SERPINF2
18 negative regulation of cellular protein metabolic process GO:0032269 9.26 EDN1 EDNRB
19 epithelial fluid transport GO:0042045 9.16 EDN1 EDNRB
20 regulation of blood pressure GO:0008217 9.13 EDN1 EDNRB NPPA
21 vein smooth muscle contraction GO:0014826 8.62 EDN1 EDNRB

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.96 C5 SERPINF2
2 signaling receptor binding GO:0005102 8.92 C5 EDN1 NPPA PLG

Sources for Acute Poststreptococcal Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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