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MCID: ACT040
MIFTS: 36

Acute Poststreptococcal Glomerulonephritis

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

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MalaCards integrated aliases for Acute Poststreptococcal Glomerulonephritis:

Name: Acute Poststreptococcal Glomerulonephritis 12 54 15
Acute Post-Streptococcal Glomerulonephritis 71
Post-Streptococcal Glomerulonephritis 12

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:14064
NCIt 49 C35443
SNOMED-CT 67 68544003
UMLS 71 C0403414
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Summaries for Acute Poststreptococcal Glomerulonephritis

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MalaCards based summary : Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to proliferative glomerulonephritis and hypertensive encephalopathy. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (Complement Factor Properdin), and among its related pathways/superpathways are Staphylococcus aureus infection and Immune response Lectin induced complement pathway. The drugs Cefpodoxime and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and skin, and related phenotype is renal/urinary system.

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Related Diseases for Acute Poststreptococcal Glomerulonephritis

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Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 262)
# Related Disease Score Top Affiliating Genes
1 proliferative glomerulonephritis 30.7 EDN1 CFHR2 C3
2 hypertensive encephalopathy 30.6 PIGN ALB
3 rheumatic fever 30.5 MYOM2 CD40LG ALB
4 impetigo 30.4 MYOM2 EDNRB CD40LG
5 purpura 30.3 CD79A CD40LG C3
6 pyoderma 30.3 MYOM2 EDNRB CD40LG
7 glomerular disease 30.3 CD79A ALB
8 pharyngitis 30.2 MYOM2 CD40LG ALB
9 exudative glomerulonephritis 30.0 PIGN CFHR2 CD40LG
10 mesangial proliferative glomerulonephritis 29.8 EDN1 CFHR2 CD79A CD40LG
11 liver cirrhosis 29.8 SERPINF2 NPPA EDN1 ALB
12 pyuria 29.7 CD40LG C3 ALB
13 glomerulonephritis 29.6 CFP CFHR5 CD79A CD40LG C3 ALB
14 acute proliferative glomerulonephritis 29.6 PIGN CD40LG C3 ALB
15 respiratory failure 29.4 NPPA EDN1 CD40LG ALB
16 rapidly progressive glomerulonephritis 29.3 PIGN CD40LG C5 C3 ALB
17 vascular disease 29.2 PLG EDNRB EDN1 CD40LG ALB
18 scarlet fever 29.2 MYOM2 EDNRB CFP CD40LG ALB
19 tetanus 29.1 CD79A CD40LG ALB
20 end stage renal disease 29.1 CFHR5 C3 ALB
21 hemolytic uremic syndrome, atypical 1 29.0 CFP CFHR5 CFHR2 C5 C3
22 hemolytic-uremic syndrome 29.0 CFHR5 CFHR2 CD40LG C5 C3
23 hypertension, essential 28.7 PLG NPPA EDNRB EDN1 CD40LG ALB
24 henoch-schoenlein purpura 28.3 PIGN CFHR2 CD79A CD40LG C3 ALB
25 thrombocytopenia 28.2 EDN1 CFHR5 CD79A CD40LG C3 ALB
26 kidney disease 28.1 NPPA EDNRB EDN1 CFHR5 CD79A C3
27 membranoproliferative glomerulonephritis 27.8 CFP CFHR5 CFHR2 CD79A C4BPA C3
28 iga glomerulonephritis 27.5 PIGN CFP CFHR5 CFHR2 CD79A CD40LG
29 systemic lupus erythematosus 27.3 CFHR5 CFHR2 CD79A CD40LG C5 C3
30 rheumatic fever-related antigen 10.5
31 livedoid vasculitis 10.5 SERPINF2 PLG
32 septicemic plague 10.5 SERPINF2 PLG
33 nephrotic syndrome 10.5
34 plasminogen deficiency, type i 10.5 SERPINF2 PLG
35 idiopathic edema 10.4 NPPA EDN1
36 myopathy, lactic acidosis, and sideroblastic anemia 3 10.4 SERPINF2 MYOM2
37 pneumococcal meningitis 10.4 C5 C3
38 neisseria meningitidis infection 10.4 CFP C3
39 malignant renovascular hypertension 10.4 EDNRB EDN1
40 encephalopathy 10.4
41 pyomyositis 10.3 MYOM2 EDNRB
42 scabies 10.3
43 transient refractive change 10.3 EDNRB EDN1
44 pneumonic plague 10.3 SERPINF2 PLG
45 complement factor i deficiency 10.3 CFP C3
46 acute kidney failure 10.3
47 hemolytic anemia 10.3
48 streptococcal group a invasive disease 10.3
49 cerebral arteritis 10.3 EDN1 CD40LG
50 seizure disorder 10.3

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to Acute Poststreptococcal Glomerulonephritis
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Symptoms & Phenotypes for Acute Poststreptococcal Glomerulonephritis

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MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.23 ALB C3 CD40LG CD79A EDN1 EDNRB
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Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

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Drugs for Acute Poststreptococcal Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefpodoxime Approved, Vet_approved 80210-62-4, 82619-04-3 6335986
2
Amoxicillin Approved, Vet_approved 26787-78-0 33613
3 Complement System Proteins
4 Immunologic Factors
5 Antistreptolysin
6 Immunoglobulins
7 Antibodies
8 Vaccines
9 Cefpodoxime proxetil
10 Cephalosporins
11 Anti-Bacterial Agents
12 Anti-Infective Agents, Local
13 penicillins
14 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Spectrum and Outcome of Acute Post Streptococcal Glomerulonephritis in Children . Unknown status NCT03184103
2 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771
3 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) - Part 5: Establishing Natural Age-Related Titers of Antibodies to the J8 Group A Streptococcal Epitope in Fiji Completed NCT00264784
4 Impact of Antibiotic Treatment of Group A Streptococcal Blistering Distal Dactylitis in Children Completed NCT02624882
5 The Molecular Epidemiology of Streptococcus Pyogenes Among Children in Leon, Nicaragua Terminated NCT00170521

Search NIH Clinical Center for Acute Poststreptococcal Glomerulonephritis

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Genetic Tests for Acute Poststreptococcal Glomerulonephritis

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Anatomical Context for Acute Poststreptococcal Glomerulonephritis

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MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

40
Kidney, Heart, Skin, Neutrophil, Liver, Monocytes, Endothelial
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Publications for Acute Poststreptococcal Glomerulonephritis

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Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50) (show all 631)
# Title Authors PMID Year
1
Streptococcal zymogen type B induces angiotensin II in mesangial cells and leukocytes. 61 54
19184118 2009
2
Increased IL-6 in supernatant of rat mesangial cell cultures treated with erythrogenic toxin type B and its precursor isolated from nephritogenic streptococci. 61 54
16534181 2006
3
Streptococcal erythrogenic toxin B induces apoptosis and proliferation in human leukocytes. 61 54
11231350 2001
4
Anticardiolipin antibodies in acute poststreptococcal glomerulonephritis and streptococcal impetigo. 54 61
10461035 1999
5
Glomerulonephritis in childhood. 61 54
9204243 1997
6
Decreased platelet counts and decreased platelet serotonin in poststreptococcal nephritis. 54 61
7723894 1995
7
Plasma terminal complement complexes in acute poststreptococcal glomerulonephritis. 54 61
1996575 1991
8
Incidence of Acute Post-Streptococcal Glomerulonephritis in Hawai'i and Factors Affecting Length of Hospitalization. 61
32432220 2020
9
[CORRELATION ANALYSIS BETWEEN CLINICO-LABORATORY AND INSTRUMENTAL INDICATORS OF CARDIAC INVOVLVEMENT IN YOUNG ADULTS SUFFERING FROM ACUTE POST-STREPTOCOCCAL GLOMERULONEPHRITIS WITH ACUTE RENO-CARDIAL SYNDROME]. 61
32535574 2020
10
Classic and Non-classic (Surrepticius) Scabies: Diagnostic and Treatment Considerations. 61
32351804 2020
11
Skin infections in Australian Aboriginal children: a narrative review. 61
31630410 2020
12
Acute post-streptococcal glomerulonephritis in Central Australia. 61
31659821 2020
13
[Infections-associated Glomerulonephritis]. 61
32069491 2020
14
Therapeutic potential of medicinal plants for the management of scabies. 61
31830356 2020
15
Clinical Profile and Immediate Outcome of Children Admitted With Acute Glomerulonephritis in Pediatrics Department of A Tertiary Level Hospital. 61
31915329 2020
16
Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis. 61
31399725 2020
17
Case Report: Concurrent Rheumatic Fever and Acute Post-Streptococcal Glomerulonephritis in a High-Burden Setting. 61
31516109 2019
18
Glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma pneumoniae induces infection-related glomerulonephritis
. 61
31496514 2019
19
Extrarenal Immune-Mediated Disorders Linked with Acute Poststreptococcal Glomerulonephritis: a Systematic Review. 61
31392657 2019
20
High burden and seasonal variation of paediatric scabies and pyoderma prevalence in The Gambia: A cross-sectional study. 61
31609963 2019
21
Post-streptococcal glomerulonephritis: Some reduction in a disease of disparities. 61
30311280 2019
22
Systematic Review of Group A Streptococcal emm Types Associated with Acute Post-Streptococcal Glomerulonephritis. 61
30915958 2019
23
Post-Streptococcal Glomerulonephritis in Two Patients Following Deceased Donor Kidney Transplant. 61
31017877 2019
24
[Zwiększenie częstości zachorowania na ostre popaciorkowcowe kłębuszkowe zapalenie nerek w pierwszej połowie roku 2018 - doświadczenie jednego ośrodka]. 61
30912519 2019
25
[Relapse of acute rheumatism fever associated with acute post-streptococcal glomerulonephritis]. 61
30665782 2019
26
A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why? 61
30760615 2019
27
A Presumed Etiology of Kawasaki Disease Based on Epidemiological Comparison With Infectious or Immune-Mediated Diseases. 61
31165053 2019
28
Acute Post-Streptococcal Glomerulonephritis in the Northern Territory of Australia: A Review of Data from 2009 to 2016 and Comparison with the Literature. 61
30398135 2018
29
[Post-streptococcal glomerulonephritis in the south of Tunisia: A 12-year retrospective review]. 61
29735420 2018
30
Factors associated with treatment outcome of acute post streptococcal glomerulonephritis among patients less than 18 years in Mekelle City, Public Hospitals, North Ethiopia. 61
30285899 2018
31
Outbreak of Glomerulonephritis Caused by Streptococcus zooepidemicus SzPHV5 Type in Monte Santo de Minas, Minas Gerais, Brazil. 61
30068536 2018
32
Nephritis-associated plasmin receptor (NAPlr) positive glomerulonephritis caused by Aggregatibacter actinomycetemcomitans bacteremia: A case report. 61
29578396 2018
33
Role of Steroids in Post-streptococcal Glomerulonephritis Without Crescents on Renal Biopsy. 61
30345206 2018
34
Pediatric post-streptococcal glomerulonephritis: Clinical and laboratory data. 61
29729114 2018
35
Poststreptococcal glomerulonephritis with atypical hemolytic uremic syndrome: An unusual presentation. 61
29970754 2018
36
Anticardiolipin antibodies in concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia: A case report. 61
29557617 2018
37
The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. 61
29269013 2018
38
Acute renal failure with need for renal replacement therapy as a complication of zoonotic S. zooepidemicus infection: case report and review of the literature. 61
28508721 2018
39
Henoch-Schonlein purpura, post-streptococcal glomerulonephritis and acute rheumatic carditis after Group A β-haemolytic streptococcal infection. 61
28162051 2018
40
Posterior Reversible Encephalopathy Syndrome Secondary to Acute PostStreptococcal Glomerulonephritis in a 12-year-old Girl. 61
29290203 2018
41
M protein gene (emm type) analysis of group A Streptococcus isolates recovered during an acute glomerulonephritis outbreak in northern Western Australia. 61
29079005 2017
42
Acute postinfectious glomerulonephritis associated with scabies in the elderly: A case report. 61
28851633 2017
43
Post-infectious glomerulonephritis. 61
28891413 2017
44
Clinical characteristics of hypertensive encephalopathy in pediatric patients. 61
29042869 2017
45
Cardiac status in children with acute poststreptococcal glomerulonephritis. 61
28748885 2017
46
A Retrospective Study of Acute Renal Failure in Children: Its Incidence, Etiology, Complications and Prognosis. 61
28652957 2017
47
Molecular biology of Group A Streptococcus and its implications in vaccine strategies. 61
28681803 2017
48
Clinical development strategy for a candidate group A streptococcal vaccine. 61
28318768 2017
49
Acute rheumatic fever and acute post-streptococcal glomerulonephritis rarely seen together. 61
28102656 2017
50
Multiple Causes of Hyponatremia: A Case Report. 61
28268230 2017
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Variations for Acute Poststreptococcal Glomerulonephritis

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Expression for Acute Poststreptococcal Glomerulonephritis

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Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.
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Pathways for Acute Poststreptococcal Glomerulonephritis

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Pathways related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Staphylococcus aureus infection 36
11.48 PLG C5 C3
2
Immune response Lectin induced complement pathway 22
Show member pathways
 11.46 CFP C5 C4BPA C3
3
Complement Pathway 63
Show member pathways
 11.34 CFP C5 C3
4
Complement and coagulation cascades 36 1
11.33 SERPINF2 PLG CFHR5 CFHR2 C5 C4BPA
5
Pertussis 36
11.21 C5 C4BPA C3
6
Dissolution of Fibrin Clot 65
10.48 SERPINF2 PLG
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GO Terms for Acute Poststreptococcal Glomerulonephritis

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Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 SERPINF2 PLG NPPA EDN1 CFP CD40LG
2 platelet alpha granule lumen GO:0031093 9.43 SERPINF2 PLG ALB
3 extracellular region GO:0005576 9.4 SERPINF2 PLG NPPA EDN1 CFP CFHR5
4 blood microparticle GO:0072562 9.35 SERPINF2 PLG C4BPA C3 ALB

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.84 EDNRB EDN1 CD79A C5
2 platelet degranulation GO:0002576 9.74 SERPINF2 PLG ALB
3 cellular protein metabolic process GO:0044267 9.73 PLG NPPA C3 ALB
4 complement activation GO:0006956 9.67 CFP C5 C3
5 fibrinolysis GO:0042730 9.58 SERPINF2 PLG
6 regulation of pH GO:0006885 9.58 EDNRB EDN1
7 vasoconstriction GO:0042310 9.56 EDNRB EDN1
8 response to muscle stretch GO:0035994 9.55 NPPA EDN1
9 regulation of blood pressure GO:0008217 9.54 NPPA EDNRB EDN1
10 positive regulation of renal sodium excretion GO:0035815 9.52 EDNRB EDN1
11 positive regulation of urine volume GO:0035810 9.51 EDNRB EDN1
12 negative regulation of fibrinolysis GO:0051918 9.48 SERPINF2 PLG
13 cytolysis by host of symbiont cells GO:0051838 9.46 CFHR5 CFHR2
14 endothelin receptor signaling pathway GO:0086100 9.4 EDNRB EDN1
15 epithelial fluid transport GO:0042045 9.32 EDNRB EDN1
16 negative regulation of cellular protein metabolic process GO:0032269 9.26 EDNRB EDN1
17 complement activation, alternative pathway GO:0006957 9.26 CFP CFHR5 C5 C3
18 vein smooth muscle contraction GO:0014826 9.16 EDNRB EDN1
19 regulation of complement activation GO:0030449 9.1 CFP CFHR5 CFHR2 C5 C4BPA C3

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.06 SKA1 SERPINF2 PLG NPPA MYOM2 EDNRB
2 signaling receptor binding GO:0005102 9.35 PLG NPPA EDN1 C5 C3
3 endopeptidase inhibitor activity GO:0004866 8.8 SERPINF2 C5 C3
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Sources for Acute Poststreptococcal Glomerulonephritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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