MCID: ACT040
MIFTS: 38

Acute Poststreptococcal Glomerulonephritis

Categories: Nephrological diseases

Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

MalaCards integrated aliases for Acute Poststreptococcal Glomerulonephritis:

Name: Acute Poststreptococcal Glomerulonephritis 12 56 15
Acute Post-Streptococcal Glomerulonephritis 74
Post-Streptococcal Glomerulonephritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14064
NCIt 51 C35443
SNOMED-CT 69 68544003
UMLS 74 C0403414

Summaries for Acute Poststreptococcal Glomerulonephritis

MalaCards based summary : Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to rapidly progressive glomerulonephritis and hemolytic uremic syndrome, atypical 1. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (Complement Factor Properdin), and among its related pathways/superpathways are Immune response Lectin induced complement pathway and Staphylococcus aureus infection. The drugs Complement System Proteins and Antistreptolysin have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and skin, and related phenotypes are cardiovascular system and renal/urinary system

Related Diseases for Acute Poststreptococcal Glomerulonephritis

Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 rapidly progressive glomerulonephritis 29.8 C5 PIGN
2 hemolytic uremic syndrome, atypical 1 29.7 C5 CFP
3 acute proliferative glomerulonephritis 11.6
4 glomerulonephritis 11.1
5 rheumatic fever-related antigen 10.4
6 rheumatic fever 10.4
7 impetigo 10.3
8 encephalopathy 10.3
9 vasculitis 10.2
10 intestinal impaction 10.2 PLG SERPINF2
11 alpha-2-plasmin inhibitor deficiency 10.2 PLG SERPINF2
12 intracranial embolism 10.2 PLG SERPINF2
13 giant hemangioma 10.2 PLG SERPINF2
14 hepatic vascular disease 10.2 EDN1 PLG
15 livedoid vasculitis 10.2 PLG SERPINF2
16 acute cor pulmonale 10.2 PLG SERPINF2
17 complement component 5 deficiency 10.2 C5 CFP
18 malignant hypertension 10.2 EDN1 NPPA
19 acute pulmonary heart disease 10.2 PLG SERPINF2
20 rheumatoid arthritis 10.2
21 arthritis 10.2
22 henoch-schoenlein purpura 10.2
23 purpura 10.2
24 hypertensive encephalopathy 10.2
25 diffuse alveolar hemorrhage 10.2
26 idiopathic edema 10.2 EDN1 NPPA
27 hepatorenal syndrome 10.2 EDN1 NPPA
28 renovascular hypertension 10.1 EDN1 NPPA
29 nodular nonsuppurative panniculitis 10.1 CFP SERPINF2
30 complement deficiency 10.1 C5 CFP
31 idiopathic hypercalciuria 10.1 EDN1 NPPA
32 angina pectoris 10.1 EDN1 SERPINF2
33 perinephritis 10.1 EDN1 EDNRB
34 pulmonary hypertension, primary, 1 10.1 EDN1 NPPA
35 coronary artery anomaly 10.0 EDN1 NPPA PLG
36 bardet-biedl syndrome 2 10.0
37 bardet-biedl syndrome 10 10.0
38 bardet-biedl syndrome 11 10.0
39 bardet-biedl syndrome 12 10.0
40 cerebral hemorrhage 10.0
41 thrombocytopenia 10.0
42 interstitial nephritis 10.0
43 nephrotic syndrome 10.0
44 hemolytic-uremic syndrome 10.0
45 bardet-biedl syndrome 10.0
46 pharyngitis 10.0
47 membranoproliferative glomerulonephritis 10.0
48 iga glomerulonephritis 10.0
49 uremia 10.0
50 proliferative glomerulonephritis 10.0

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to Acute Poststreptococcal Glomerulonephritis

Symptoms & Phenotypes for Acute Poststreptococcal Glomerulonephritis

MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 CFP EDN1 EDNRB NPPA PLG
2 renal/urinary system MP:0005367 8.92 EDN1 EDNRB NPPA PLG

Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

Drugs for Acute Poststreptococcal Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Complement System Proteins
2 Antistreptolysin
3 Immunologic Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hospital Based Incidence of Group A Streptococcal Disease in Fiji Completed NCT00264771
2 Acute Post Streptococcal Glomerulonephritis Not yet recruiting NCT03184103

Search NIH Clinical Center for Acute Poststreptococcal Glomerulonephritis

Genetic Tests for Acute Poststreptococcal Glomerulonephritis

Anatomical Context for Acute Poststreptococcal Glomerulonephritis

MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

42
Kidney, Heart, Skin, Monocytes, Brain, Spleen, Liver

Publications for Acute Poststreptococcal Glomerulonephritis

Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50) (show all 212)
# Title Authors Year
1
Systematic Review of Group A Streptococcal emm Types Associated with Acute Post-Streptococcal Glomerulonephritis. ( 30915958 )
2019
2
Acute Post-Streptococcal Glomerulonephritis in the Northern Territory of Australia: A Review of Data from 2009 to 2016 and Comparison with the Literature. ( 30398135 )
2018
3
Factors associated with treatment outcome of acute post streptococcal glomerulonephritis among patients less than 18 years in Mekelle City, Public Hospitals, North Ethiopia. ( 30285899 )
2018
4
Posterior Reversible Encephalopathy Syndrome Secondary to Acute PostStreptococcal Glomerulonephritis in a 12-year-old Girl. ( 29290203 )
2018
5
Acute rheumatic fever and acute post-streptococcal glomerulonephritis rarely seen together. ( 28102656 )
2017
6
Cardiac status in children with acute poststreptococcal glomerulonephritis. ( 28748885 )
2017
7
HIT or Miss: The Sequential Diagnostic Approach to Heparin-Induced Thrombocytopenia Illustrated in a Child With Acute Post-Streptococcal Glomerulonephritis. ( 25963179 )
2016
8
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: An uncommon coincidence. ( 27625530 )
2016
9
Posterior Reversible Encephalopathy Syndrome and Acute Post-Streptococcal Glomerulonephritis Mimicking Breakthrough Seizures. ( 26294945 )
2015
10
IgA-dominant acute poststreptococcal glomerulonephritis with concomitant rheumatic fever successfully treated with steroids: a case report. ( 26718763 )
2015
11
Diffuse alveolar hemorrhage in a patient with acute poststreptococcal glomerulonephritis caused by impetigo. ( 25876581 )
2015
12
Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis. ( 25554106 )
2015
13
A case of acute post-streptococcal glomerulonephritis that developed posterior reversible encephalopathy syndrome. ( 26078688 )
2014
14
Prognosis of acute post-streptococcal glomerulonephritis in Sudanese children. ( 25366505 )
2014
15
Diffuse alveolar hemorrhage as a presentation of acute poststreptococcal glomerulonephritis. ( 24927907 )
2014
16
Acute post-streptococcal glomerulonephritis with acute kidney injury in nephrotic syndrome with the glomerular deposition of nephritis-associated plasmin receptor antigen. ( 24042518 )
2013
17
Severe hypoalphalipoproteinaemia in a child with acute post-streptococcal glomerulonephritis (APSGN). ( 24194163 )
2013
18
Severe acute post-streptococcal glomerulonephritis in an infant. ( 23640628 )
2013
19
Risk factors and outcome of atypical acute post-streptococcal glomerulonephritis in pediatrics. ( 23691638 )
2013
20
Acute poststreptococcal glomerulonephritis with acute interstitial nephritis related to streptococcal pyrogenic exotoxin B. ( 26064502 )
2013
21
Acute poststreptococcal glomerulonephritis: a manifestation of immune reconstitution inflammatory syndrome. ( 22891230 )
2012
22
Acute post-streptococcal glomerulonephritis in the Northern Territory of Australia: a review of 16 years data and comparison with the literature. ( 21976576 )
2011
23
Acute reversible changes of brachial-ankle pulse wave velocity in children with acute poststreptococcal glomerulonephritis. ( 20640906 )
2011
24
Clinicopathological features and prognosis of Chinese patients with acute post-streptococcal glomerulonephritis. ( 20883283 )
2010
25
Acute post-streptococcal glomerulonephritis in children of French Polynesia: a 3-year retrospective study. ( 19876655 )
2010
26
Unfavorable outcome in a child with megaureter-megacystis syndrome complicated by mild acute poststreptococcal glomerulonephritis. ( 21166952 )
2010
27
Localization of nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis. ( 20708459 )
2010
28
Evidence-based treatment limitations prevent any therapeutic recommendation for acute poststreptococcal glomerulonephritis in children. ( 20357732 )
2010
29
Rapidly progressive acute post-streptococcal glomerulonephritis in a child with IgA nephropathy. ( 19500287 )
2009
30
Immune globulin-responsive thrombocytopenia in acute post-streptococcal glomerulonephritis: report of a case in Hawai'i. ( 19441614 )
2009
31
A case of rheumatic fever with acute post-streptococcal glomerulonephritis and nephrotic syndrome caused by a cutaneous infection with beta-hemolytic streptococci. ( 25386236 )
2009
32
Outcome of severe acute post-streptococcal glomerulonephritis in New Zealand children. ( 19096879 )
2009
33
Elevated plasma levels of N-terminal pro-brain natriuretic peptide in children with acute poststreptococcal glomerulonephritis. ( 19346734 )
2009
34
Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis. ( 19095947 )
2009
35
Acute post-streptococcal glomerulonephritis associated with prolonged hypocomplementaemia. ( 18820103 )
2008
36
Autoantibodies against complement C1q in acute post-streptococcal glomerulonephritis. ( 18544473 )
2008
37
Cerebral vasculitis and unilateral sixth-nerve palsy in acute post-streptococcal glomerulonephritis. ( 18510827 )
2008
38
Changing epidemiology of acute post-streptococcal glomerulonephritis in Northeast Florida: a comparative study. ( 18373105 )
2008
39
Acute poststreptococcal glomerulonephritis superimposed on IgA nephropathy. ( 18793531 )
2008
40
Acute poststreptococcal glomerulonephritis: an update. ( 18332711 )
2008
41
Elevated urinary plasmin activity resistant to alpha2-antiplasmin in acute poststreptococcal glomerulonephritis. ( 18223261 )
2008
42
Sequence and expression of NAPlr is conserved among group A streptococci isolated from patients with acute poststreptococcal glomerulonephritis (APSGN) and non-APSGN. ( 17557271 )
2007
43
Significance of glomerular cell apoptosis in the resolution of acute post-streptococcal glomerulonephritis. ( 17205964 )
2007
44
Acute post-streptococcal glomerulonephritis in a 14-month-old boy: why is this uncommon? ( 17043882 )
2007
45
Nephritogenic antigen for acute poststreptococcal glomerulonephritis. ( 16518356 )
2006
46
Antibodies against four proteins from a Streptococcus pyogenes serotype M1 strain and levels of circulating mannan-binding lectin in acute poststreptococcal glomerulonephritis. ( 16508336 )
2006
47
Why is acute post-streptococcal glomerulonephritis more common in the pediatric population? ( 16791408 )
2006
48
Posterior reversible encephalopathy syndrome revealing acute post-streptococcal glomerulonephritis. ( 16901429 )
2006
49
An outbreak of acute post-streptococcal glomerulonephritis in remote Far North Queensland. ( 16911165 )
2006
50
An adult with acute poststreptococcal glomerulonephritis complicated by hemolytic uremic syndrome and nephrotic syndrome. ( 16183409 )
2005

Variations for Acute Poststreptococcal Glomerulonephritis

Expression for Acute Poststreptococcal Glomerulonephritis

Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.

Pathways for Acute Poststreptococcal Glomerulonephritis

GO Terms for Acute Poststreptococcal Glomerulonephritis

Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 C4BPA C5 CFP EDN1 NPPA PLG
2 blood microparticle GO:0072562 9.43 C4BPA PLG SERPINF2
3 platelet alpha granule lumen GO:0031093 9.32 PLG SERPINF2
4 collagen-containing extracellular matrix GO:0062023 9.26 CFP NPPA PLG SERPINF2
5 extracellular space GO:0005615 9.17 C4BPA C5 CFP EDN1 NPPA PLG

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.76 C5 EDN1 EDNRB
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.6 EDN1 SERPINF2
3 sensory perception of pain GO:0019233 9.59 EDN1 EDNRB
4 regulation of sensory perception of pain GO:0051930 9.58 EDN1 EDNRB
5 blood vessel morphogenesis GO:0048514 9.57 EDN1 SERPINF2
6 cGMP-mediated signaling GO:0019934 9.56 EDNRB NPPA
7 fibrinolysis GO:0042730 9.55 PLG SERPINF2
8 positive regulation of heart rate GO:0010460 9.54 EDN1 NPPA
9 regulation of complement activation GO:0030449 9.54 C4BPA C5 CFP
10 regulation of pH GO:0006885 9.52 EDN1 EDNRB
11 regulation of blood vessel size GO:0050880 9.51 EDN1 NPPA
12 vasoconstriction GO:0042310 9.49 EDN1 EDNRB
13 response to muscle stretch GO:0035994 9.48 EDN1 NPPA
14 positive regulation of renal sodium excretion GO:0035815 9.46 EDN1 EDNRB
15 positive regulation of urine volume GO:0035810 9.43 EDN1 EDNRB
16 complement activation, alternative pathway GO:0006957 9.4 C5 CFP
17 negative regulation of fibrinolysis GO:0051918 9.32 PLG SERPINF2
18 epithelial fluid transport GO:0042045 9.26 EDN1 EDNRB
19 negative regulation of cellular protein metabolic process GO:0032269 9.16 EDN1 EDNRB
20 regulation of blood pressure GO:0008217 9.13 EDN1 EDNRB NPPA
21 vein smooth muscle contraction GO:0014826 8.62 EDN1 EDNRB

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.96 C5 SERPINF2
2 signaling receptor binding GO:0005102 8.92 C5 EDN1 NPPA PLG

Sources for Acute Poststreptococcal Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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