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MCID: ACT040
MIFTS: 36

Acute Poststreptococcal Glomerulonephritis

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

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MalaCards integrated aliases for Acute Poststreptococcal Glomerulonephritis:

Name: Acute Poststreptococcal Glomerulonephritis 12 54 15
Acute Post-Streptococcal Glomerulonephritis 71
Post-Streptococcal Glomerulonephritis 12

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:14064
NCIt 49 C35443
SNOMED-CT 67 68544003
UMLS 71 C0403414
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Summaries for Acute Poststreptococcal Glomerulonephritis

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MalaCards based summary : Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to impetigo and exudative glomerulonephritis. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (Complement Factor Properdin), and among its related pathways/superpathways are Complement Pathway and Staphylococcus aureus infection. The drugs Cefpodoxime and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related phenotype is renal/urinary system.

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Related Diseases for Acute Poststreptococcal Glomerulonephritis

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Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 261)
# Related Disease Score Top Affiliating Genes
1 impetigo 30.5 MYOM2 EDNRB CD40LG
2 exudative glomerulonephritis 30.4 PIGN CD40LG
3 mesangial proliferative glomerulonephritis 30.3 EDN1 CD79A CD40LG
4 rheumatic fever 30.3 MYOM2 CD40LG ALB
5 purpura 30.2 CD79A CD40LG C3
6 glomerular disease 30.0 CD79A ALB
7 henoch-schoenlein purpura 29.8 CFHR2 CD79A CD40LG
8 glomerulonephritis 29.6 CFP CFHR5 CD79A CD40LG C3 ALB
9 liver cirrhosis 29.5 SERPINF2 NPPA EDN1 ALB
10 pyuria 29.4 CD40LG C3 ALB
11 acute proliferative glomerulonephritis 29.3 PIGN CD40LG C3 ALB
12 hemolytic uremic syndrome, atypical 1 29.3 CFP CFHR5 CFHR2 C5 C3
13 hemolytic-uremic syndrome 29.2 CFHR5 CFHR2 CD40LG C5 C3
14 vascular disease 29.0 PLG EDNRB EDN1 CD40LG ALB
15 tetanus 29.0 CD79A CD40LG ALB
16 scarlet fever 29.0 MYOM2 EDNRB CFP CD40LG ALB
17 rapidly progressive glomerulonephritis 28.8 PIGN CFP CD40LG C5 C3 ALB
18 kidney disease 28.7 NPPA EDNRB EDN1 CD79A C3 ALB
19 hypertension, essential 28.5 PLG NPPA EDNRB EDN1 CD40LG ALB
20 thrombocytopenia 28.4 CFHR5 CD79A CD40LG C3 ALB
21 membranoproliferative glomerulonephritis 28.1 CFP CFHR5 CFHR2 CD79A C3 ALB
22 iga glomerulonephritis 27.7 PIGN CFHR5 CFHR2 CD79A CD40LG C3
23 rheumatic fever-related antigen 10.5
24 nephrotic syndrome 10.5
25 intracranial embolism 10.4 SERPINF2 PLG
26 idiopathic edema 10.4 NPPA EDN1
27 night blindness, congenital stationary, type 1h 10.4 EDNRB EDN1
28 diffuse glomerulonephritis 10.4 CFP C3
29 pneumococcal meningitis 10.4 C5 C3
30 malignant renovascular hypertension 10.4 EDNRB EDN1
31 pharyngitis 10.4
32 proliferative glomerulonephritis 10.4
33 encephalopathy 10.4
34 alpha-2-plasmin inhibitor deficiency 10.3 SERPINF2 PLG
35 neisseria meningitidis infection 10.3 CFP C3
36 malignant hypertensive renal disease 10.3 EDNRB EDN1
37 scabies 10.3
38 acute kidney failure 10.3
39 hemolytic anemia 10.3
40 hypertensive encephalopathy 10.3
41 streptococcal group a invasive disease 10.3
42 intracranial sinus thrombosis 10.3 PLG CD40LG
43 complement factor i deficiency 10.3 CFP C3
44 seizure disorder 10.3
45 oral tuberculosis 10.2 EDNRB C3
46 tick-borne relapsing fever 10.2 CFHR2 C3
47 retinal vascular occlusion 10.2 PLG EDN1 CFHR2
48 malignant hypertension 10.2 NPPA EDN1 CFHR2
49 osteosclerotic myeloma 10.2 MYOM2 CD40LG
50 solitary osseous plasmacytoma 10.2 MYOM2 CD79A

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to Acute Poststreptococcal Glomerulonephritis
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Symptoms & Phenotypes for Acute Poststreptococcal Glomerulonephritis

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MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.23 ALB C3 CD40LG CD79A EDN1 EDNRB
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Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

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Drugs for Acute Poststreptococcal Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefpodoxime Approved, Vet_approved 80210-62-4, 82619-04-3 6335986
2
Amoxicillin Approved, Vet_approved 26787-78-0 33613
3 Vaccines
4 Antibodies
5 Immunoglobulins
6 Antitubercular Agents
7 Antibiotics, Antitubercular
8 Cephalosporins
9 Anti-Bacterial Agents
10 Anti-Infective Agents, Local
11 Cefpodoxime proxetil
12 Anti-Infective Agents
13 penicillins
14 Immunologic Factors
15 Complement System Proteins
16 Antistreptolysin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771
2 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) - Part 5: Establishing Natural Age-Related Titers of Antibodies to the J8 Group A Streptococcal Epitope in Fiji Completed NCT00264784
3 Impact of Antibiotic Treatment of Group A Streptococcal Blistering Distal Dactylitis in Children Completed NCT02624882
4 Clinical Spectrum and Outcome of Acute Post Streptococcal Glomerulonephritis in Children . Not yet recruiting NCT03184103
5 The Molecular Epidemiology of Streptococcus Pyogenes Among Children in Leon, Nicaragua Terminated NCT00170521

Search NIH Clinical Center for Acute Poststreptococcal Glomerulonephritis

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Genetic Tests for Acute Poststreptococcal Glomerulonephritis

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Anatomical Context for Acute Poststreptococcal Glomerulonephritis

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MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

40
Heart, Kidney, Liver, Lung, Skin, Neutrophil, Monocytes
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Publications for Acute Poststreptococcal Glomerulonephritis

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Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50) (show all 627)
# Title Authors PMID Year
1
Streptococcal zymogen type B induces angiotensin II in mesangial cells and leukocytes. 54 61
19184118 2009
2
Increased IL-6 in supernatant of rat mesangial cell cultures treated with erythrogenic toxin type B and its precursor isolated from nephritogenic streptococci. 54 61
16534181 2006
3
Streptococcal erythrogenic toxin B induces apoptosis and proliferation in human leukocytes. 54 61
11231350 2001
4
Anticardiolipin antibodies in acute poststreptococcal glomerulonephritis and streptococcal impetigo. 54 61
10461035 1999
5
Glomerulonephritis in childhood. 54 61
9204243 1997
6
Decreased platelet counts and decreased platelet serotonin in poststreptococcal nephritis. 54 61
7723894 1995
7
Plasma terminal complement complexes in acute poststreptococcal glomerulonephritis. 54 61
1996575 1991
8
Therapeutic potential of medicinal plants for the management of scabies. 61
31830356 2020
9
Clinical Profile and Immediate Outcome of Children Admitted With Acute Glomerulonephritis in Pediatrics Department of A Tertiary Level Hospital. 61
31915329 2020
10
Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis. 61
31399725 2020
11
Case Report: Concurrent Rheumatic Fever and Acute Post-Streptococcal Glomerulonephritis in a High-Burden Setting. 61
31516109 2019
12
Glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma pneumoniae induces infection-related glomerulonephritis
. 61
31496514 2019
13
Skin infections in Australian Aboriginal children: a narrative review. 61
31630410 2019
14
Extrarenal Immune-Mediated Disorders Linked with Acute Poststreptococcal Glomerulonephritis: a Systematic Review. 61
31392657 2019
15
High burden and seasonal variation of paediatric scabies and pyoderma prevalence in The Gambia: A cross-sectional study. 61
31609963 2019
16
Acute post-streptococcal glomerulonephritis in Central Australia. 61
31659821 2019
17
Post-streptococcal glomerulonephritis: Some reduction in a disease of disparities. 61
30311280 2019
18
Systematic Review of Group A Streptococcal emm Types Associated with Acute Post-Streptococcal Glomerulonephritis. 61
30915958 2019
19
Post-Streptococcal Glomerulonephritis in Two Patients Following Deceased Donor Kidney Transplant. 61
31017877 2019
20
[Zwiększenie częstości zachorowania na ostre popaciorkowcowe kłębuszkowe zapalenie nerek w pierwszej połowie roku 2018 - doświadczenie jednego ośrodka]. 61
30912519 2019
21
[Relapse of acute rheumatism fever associated with acute post-streptococcal glomerulonephritis]. 61
30665782 2019
22
A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why? 61
30760615 2019
23
A Presumed Etiology of Kawasaki Disease Based on Epidemiological Comparison With Infectious or Immune-Mediated Diseases. 61
31165053 2019
24
[Post-streptococcal glomerulonephritis in the south of Tunisia: A 12-year retrospective review]. 61
29735420 2018
25
Acute Post-Streptococcal Glomerulonephritis in the Northern Territory of Australia: A Review of Data from 2009 to 2016 and Comparison with the Literature. 61
30398135 2018
26
Factors associated with treatment outcome of acute post streptococcal glomerulonephritis among patients less than 18 years in Mekelle City, Public Hospitals, North Ethiopia. 61
30285899 2018
27
Outbreak of Glomerulonephritis Caused by Streptococcus zooepidemicus SzPHV5 Type in Monte Santo de Minas, Minas Gerais, Brazil. 61
30068536 2018
28
Role of Steroids in Post-streptococcal Glomerulonephritis Without Crescents on Renal Biopsy. 61
30345206 2018
29
Nephritis-associated plasmin receptor (NAPlr) positive glomerulonephritis caused by Aggregatibacter actinomycetemcomitans bacteremia: A case report. 61
29578396 2018
30
Pediatric post-streptococcal glomerulonephritis: Clinical and laboratory data. 61
29729114 2018
31
Poststreptococcal glomerulonephritis with atypical hemolytic uremic syndrome: An unusual presentation. 61
29970754 2018
32
Anticardiolipin antibodies in concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia: A case report. 61
29557617 2018
33
The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. 61
29269013 2018
34
Acute renal failure with need for renal replacement therapy as a complication of zoonotic S. zooepidemicus infection: case report and review of the literature. 61
28508721 2018
35
Henoch-Schonlein purpura, post-streptococcal glomerulonephritis and acute rheumatic carditis after Group A β-haemolytic streptococcal infection. 61
28162051 2018
36
Posterior Reversible Encephalopathy Syndrome Secondary to Acute PostStreptococcal Glomerulonephritis in a 12-year-old Girl. 61
29290203 2018
37
M protein gene (emm type) analysis of group A Streptococcus isolates recovered during an acute glomerulonephritis outbreak in northern Western Australia. 61
29079005 2017
38
Acute postinfectious glomerulonephritis associated with scabies in the elderly: A case report. 61
28851633 2017
39
Post-infectious glomerulonephritis. 61
28891413 2017
40
Clinical characteristics of hypertensive encephalopathy in pediatric patients. 61
29042869 2017
41
Cardiac status in children with acute poststreptococcal glomerulonephritis. 61
28748885 2017
42
A Retrospective Study of Acute Renal Failure in Children: Its Incidence, Etiology, Complications and Prognosis. 61
28652957 2017
43
Molecular biology of Group A Streptococcus and its implications in vaccine strategies. 61
28681803 2017
44
Clinical development strategy for a candidate group A streptococcal vaccine. 61
28318768 2017
45
Acute rheumatic fever and acute post-streptococcal glomerulonephritis rarely seen together. 61
28102656 2017
46
Multiple Causes of Hyponatremia: A Case Report. 61
28268230 2017
47
Posterior reversible encephalopathy syndrome in children: a case series. 61
28123335 2016
48
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: An uncommon coincidence. 61
27625530 2016
49
Different antibiotic treatments for group A streptococcal pharyngitis. 61
27614728 2016
50
Accelerating the development of a group A Streptococcus vaccine: an urgent public health need. 61
27489799 2016
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Variations for Acute Poststreptococcal Glomerulonephritis

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Expression for Acute Poststreptococcal Glomerulonephritis

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Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.
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Pathways for Acute Poststreptococcal Glomerulonephritis

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Pathways related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Complement Pathway 63
Show member pathways
 11.57 CFP C5 C3
2
Staphylococcus aureus infection 36
11.42 PLG C5 C3
3
Immune response Lectin induced complement pathway 22
Show member pathways
 11.38 CFP C5 C4BPA C3
4
Complement and coagulation cascades 1 36
11.33 SERPINF2 PLG CFHR5 CFHR2 C5 C4BPA
5
Pertussis 36
11.21 C5 C4BPA C3
6
Dissolution of Fibrin Clot 65
10.44 SERPINF2 PLG
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GO Terms for Acute Poststreptococcal Glomerulonephritis

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Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 SERPINF2 PLG NPPA EDN1 CFP CD40LG
2 protein-containing complex GO:0032991 9.72 NPPA CFHR5 CFHR2 C3 ALB
3 collagen-containing extracellular matrix GO:0062023 9.67 SERPINF2 PLG NPPA CFP
4 platelet alpha granule lumen GO:0031093 9.43 SERPINF2 PLG ALB
5 extracellular region GO:0005576 9.4 SERPINF2 PLG NPPA EDN1 CFP CFHR5
6 blood microparticle GO:0072562 9.35 SERPINF2 PLG C4BPA C3 ALB

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.76 EDNRB EDN1 CD79A C5
2 platelet degranulation GO:0002576 9.73 SERPINF2 PLG ALB
3 cellular protein metabolic process GO:0044267 9.73 PLG NPPA C3 ALB
4 complement activation GO:0006956 9.67 CFP C5 C3
5 regulation of pH GO:0006885 9.57 EDNRB EDN1
6 vasoconstriction GO:0042310 9.55 EDNRB EDN1
7 response to muscle stretch GO:0035994 9.54 NPPA EDN1
8 regulation of blood pressure GO:0008217 9.54 NPPA EDNRB EDN1
9 positive regulation of renal sodium excretion GO:0035815 9.52 EDNRB EDN1
10 positive regulation of urine volume GO:0035810 9.51 EDNRB EDN1
11 negative regulation of fibrinolysis GO:0051918 9.48 SERPINF2 PLG
12 positive regulation of cytolysis GO:0045919 9.4 CFHR5 CFHR2
13 epithelial fluid transport GO:0042045 9.32 EDNRB EDN1
14 negative regulation of cellular protein metabolic process GO:0032269 9.26 EDNRB EDN1
15 complement activation, alternative pathway GO:0006957 9.26 CFP CFHR5 C5 C3
16 vein smooth muscle contraction GO:0014826 9.16 EDNRB EDN1
17 regulation of complement activation GO:0030449 9.1 CFP CFHR5 CFHR2 C5 C4BPA C3

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.06 SKA1 SERPINF2 PLG NPPA MYOM2 EDNRB
2 signaling receptor binding GO:0005102 9.35 PLG NPPA EDN1 C5 C3
3 endopeptidase inhibitor activity GO:0004866 8.8 SERPINF2 C5 C3
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Sources for Acute Poststreptococcal Glomerulonephritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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