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MCID: ACT040
MIFTS: 36

Acute Poststreptococcal Glomerulonephritis

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

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MalaCards integrated aliases for Acute Poststreptococcal Glomerulonephritis:

Name: Acute Poststreptococcal Glomerulonephritis 12 54 15
Acute Post-Streptococcal Glomerulonephritis 71
Post-Streptococcal Glomerulonephritis 12

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:14064
NCIt 50 C35443
SNOMED-CT 67 68544003
UMLS 71 C0403414
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Summaries for Acute Poststreptococcal Glomerulonephritis

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MalaCards based summary : Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to hypertensive encephalopathy and proliferative glomerulonephritis. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (Complement Factor Properdin), and among its related pathways/superpathways are Creation of C4 and C2 activators and Immune response Lectin induced complement pathway. The drugs Immunologic Factors and Complement System Proteins have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and neutrophil, and related phenotypes are homeostasis/metabolism and renal/urinary system

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Related Diseases for Acute Poststreptococcal Glomerulonephritis

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Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
# Related Disease Score Top Affiliating Genes
1 hypertensive encephalopathy 30.6 EDN1 ALB
2 proliferative glomerulonephritis 30.5 EDN1 CFH C3
3 acute kidney failure 30.4 NPPA CFH ALB
4 acute proliferative glomerulonephritis 30.3 C3 ALB
5 glomerulonephritis 30.2 CFP CFHR5 CFH CD79A C3 ALB
6 mesangial proliferative glomerulonephritis 30.1 EDN1 CFHR2 CD79A
7 rapidly progressive glomerulonephritis 30.1 CFP C5 C3 ALB
8 glomerular disease 30.1 CD79A ALB
9 pyuria 30.1 C3 ALB
10 congestive heart failure 29.8 NPPA EDN1 ALB
11 exudative glomerulonephritis 29.8 CFHR5 CFHR2 CFH
12 liver cirrhosis 29.8 SERPINF2 NPPA EDN1 ALB
13 scarlet fever 29.6 MYOM2 EDNRB CFP C3 ALB
14 hemolytic-uremic syndrome 29.5 CFHR5 CFHR2 CFH C5 C3
15 chronic kidney disease 29.4 NPPA EDN1 CFH ALB
16 end stage renal disease 29.3 CFHR5 CFH C3 ALB
17 hypertension, essential 29.3 PLG NPPA EDNRB EDN1 C3 ALB
18 henoch-schoenlein purpura 29.2 CFHR2 CD79A C3 ALB
19 iga glomerulonephritis 29.1 CFP CFHR2 CFH CD79A C3 ALB
20 thrombocytopenia 28.6 PLG EDN1 CFHR5 CFH CD79A C3
21 hemolytic uremic syndrome, atypical 1 28.6 CFP CFHR5 CFHR2 CFH C5 C3
22 kidney disease 28.2 NPPA EDNRB EDN1 CFHR5 CFH CD79A
23 membranoproliferative glomerulonephritis 28.2 CFP CFHR5 CFHR2 CFH CD79A C3
24 rheumatic fever-related antigen 10.6
25 rheumatic fever 10.6
26 proteinuria, chronic benign 10.5
27 nephrotic syndrome 10.5
28 pharyngitis 10.4
29 livedoid vasculitis 10.4 SERPINF2 PLG
30 septicemic plague 10.3 SERPINF2 PLG
31 plasminogen deficiency, type i 10.3 SERPINF2 PLG
32 purpura 10.3
33 vasculitis 10.3
34 perforated corneal ulcer 10.3 SERPINF2 PLG
35 streptococcal meningitis 10.3 MYOM2 CFP
36 pneumonic plague 10.3 SERPINF2 PLG
37 alpha-2-plasmin inhibitor deficiency 10.3 SERPINF2 PLG
38 diffuse glomerulonephritis 10.3 CFP C3
39 scabies 10.3
40 idiopathic edema 10.3 NPPA EDN1
41 central retinal artery occlusion 10.3 PLG EDN1
42 hemolytic anemia 10.3
43 impetigo 10.3
44 streptococcal group a invasive disease 10.3
45 encephalopathy 10.3
46 pneumococcal meningitis 10.3 C5 C3
47 lateral myocardial infarction 10.3 PLG C3
48 neisseria meningitidis infection 10.3 CFP C3
49 middle cerebral artery infarction 10.3 PLG EDN1
50 acquired color blindness 10.3 EDNRB EDN1

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to Acute Poststreptococcal Glomerulonephritis
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Symptoms & Phenotypes for Acute Poststreptococcal Glomerulonephritis

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MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 ALB C3 C5 CD79A CFH CFP
2 renal/urinary system MP:0005367 9.28 ALB C3 C5 CD79A CFH EDN1
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Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

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Drugs for Acute Poststreptococcal Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors
2 Complement System Proteins
3 Antistreptolysin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Spectrum and Outcome of Acute Post Streptococcal Glomerulonephritis in Children . Unknown status NCT03184103
2 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771

Search NIH Clinical Center for Acute Poststreptococcal Glomerulonephritis

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Genetic Tests for Acute Poststreptococcal Glomerulonephritis

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Anatomical Context for Acute Poststreptococcal Glomerulonephritis

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MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

40
Kidney, Skin, Neutrophil, Heart, Endothelial, Spleen, Monocytes
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Publications for Acute Poststreptococcal Glomerulonephritis

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Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50) (show all 635)
# Title Authors PMID Year
1
Streptococcal zymogen type B induces angiotensin II in mesangial cells and leukocytes. 61 54
19184118 2009
2
Increased IL-6 in supernatant of rat mesangial cell cultures treated with erythrogenic toxin type B and its precursor isolated from nephritogenic streptococci. 61 54
16534181 2006
3
Streptococcal erythrogenic toxin B induces apoptosis and proliferation in human leukocytes. 54 61
11231350 2001
4
Anticardiolipin antibodies in acute poststreptococcal glomerulonephritis and streptococcal impetigo. 54 61
10461035 1999
5
Glomerulonephritis in childhood. 54 61
9204243 1997
6
Decreased platelet counts and decreased platelet serotonin in poststreptococcal nephritis. 54 61
7723894 1995
7
Plasma terminal complement complexes in acute poststreptococcal glomerulonephritis. 61 54
1996575 1991
8
Clinico-radiological Profile of Posterior Reversible Encephalopathy Syndrome and Its Associated Risk Factors in PICU: A Single-center Experience from a Tertiary Care Hospital in Bhubaneswar, Odisha. 61
33446977 2020
9
Acute post-streptococcal glomerulonephritis: analysis of the pathogenesis. 61
33030969 2020
10
Myocarditis and intracardiac thrombus due to Henoch-Schönlein purpura: case report and literature review. 61
32789615 2020
11
Coexistence of acute poststreptococcal glomerulonephritis and acute rheumatic fever in a Japanese girl with primary Sjögren's syndrome. 61
33087015 2020
12
Incidence of Acute Post-Streptococcal Glomerulonephritis in Hawai'i and Factors Affecting Length of Hospitalization. 61
32432220 2020
13
[CORRELATION ANALYSIS BETWEEN CLINICO-LABORATORY AND INSTRUMENTAL INDICATORS OF CARDIAC INVOVLVEMENT IN YOUNG ADULTS SUFFERING FROM ACUTE POST-STREPTOCOCCAL GLOMERULONEPHRITIS WITH ACUTE RENO-CARDIAL SYNDROME]. 61
32535574 2020
14
Classic and Non-classic (Surrepticius) Scabies: Diagnostic and Treatment Considerations. 61
32351804 2020
15
Skin infections in Australian Aboriginal children: a narrative review. 61
31630410 2020
16
Acute post-streptococcal glomerulonephritis in Central Australia. 61
31659821 2020
17
[Infections-associated Glomerulonephritis]. 61
32069491 2020
18
Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis. 61
31399725 2020
19
Clinical Profile and Immediate Outcome of Children Admitted With Acute Glomerulonephritis in Pediatrics Department of A Tertiary Level Hospital. 61
31915329 2020
20
Therapeutic potential of medicinal plants for the management of scabies. 61
31830356 2020
21
Case Report: Concurrent Rheumatic Fever and Acute Post-Streptococcal Glomerulonephritis in a High-Burden Setting. 61
31516109 2019
22
Glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma pneumoniae induces infection-related glomerulonephritis
. 61
31496514 2019
23
Extrarenal Immune-Mediated Disorders Linked with Acute Poststreptococcal Glomerulonephritis: a Systematic Review. 61
31392657 2019
24
High burden and seasonal variation of paediatric scabies and pyoderma prevalence in The Gambia: A cross-sectional study. 61
31609963 2019
25
Post-streptococcal glomerulonephritis: Some reduction in a disease of disparities. 61
30311280 2019
26
Systematic Review of Group A Streptococcal emm Types Associated with Acute Post-Streptococcal Glomerulonephritis. 61
30915958 2019
27
Post-Streptococcal Glomerulonephritis in Two Patients Following Deceased Donor Kidney Transplant. 61
31017877 2019
28
[Zwiększenie częstości zachorowania na ostre popaciorkowcowe kłębuszkowe zapalenie nerek w pierwszej połowie roku 2018 - doświadczenie jednego ośrodka]. 61
30912519 2019
29
[Relapse of acute rheumatism fever associated with acute post-streptococcal glomerulonephritis]. 61
30665782 2019
30
A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why? 61
30760615 2019
31
A Presumed Etiology of Kawasaki Disease Based on Epidemiological Comparison With Infectious or Immune-Mediated Diseases. 61
31165053 2019
32
Acute Post-Streptococcal Glomerulonephritis in the Northern Territory of Australia: A Review of Data from 2009 to 2016 and Comparison with the Literature. 61
30398135 2018
33
[Post-streptococcal glomerulonephritis in the south of Tunisia: A 12-year retrospective review]. 61
29735420 2018
34
Outbreak of Glomerulonephritis Caused by Streptococcus zooepidemicus SzPHV5 Type in Monte Santo de Minas, Minas Gerais, Brazil. 61
30068536 2018
35
Factors associated with treatment outcome of acute post streptococcal glomerulonephritis among patients less than 18 years in Mekelle City, Public Hospitals, North Ethiopia. 61
30285899 2018
36
Role of Steroids in Post-streptococcal Glomerulonephritis Without Crescents on Renal Biopsy. 61
30345206 2018
37
Nephritis-associated plasmin receptor (NAPlr) positive glomerulonephritis caused by Aggregatibacter actinomycetemcomitans bacteremia: A case report. 61
29578396 2018
38
Pediatric post-streptococcal glomerulonephritis: Clinical and laboratory data. 61
29729114 2018
39
Poststreptococcal glomerulonephritis with atypical hemolytic uremic syndrome: An unusual presentation. 61
29970754 2018
40
Anticardiolipin antibodies in concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia: A case report. 61
29557617 2018
41
The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. 61
29269013 2018
42
Acute renal failure with need for renal replacement therapy as a complication of zoonotic S. zooepidemicus infection: case report and review of the literature. 61
28508721 2018
43
Henoch-Schonlein purpura, post-streptococcal glomerulonephritis and acute rheumatic carditis after Group A β-haemolytic streptococcal infection. 61
28162051 2018
44
Posterior Reversible Encephalopathy Syndrome Secondary to Acute PostStreptococcal Glomerulonephritis in a 12-year-old Girl. 61
29290203 2018
45
Acute postinfectious glomerulonephritis associated with scabies in the elderly: A case report. 61
28851633 2017
46
M protein gene (emm type) analysis of group A Streptococcus isolates recovered during an acute glomerulonephritis outbreak in northern Western Australia. 61
29079005 2017
47
Post-infectious glomerulonephritis. 61
28891413 2017
48
Clinical characteristics of hypertensive encephalopathy in pediatric patients. 61
29042869 2017
49
Cardiac status in children with acute poststreptococcal glomerulonephritis. 61
28748885 2017
50
A Retrospective Study of Acute Renal Failure in Children: Its Incidence, Etiology, Complications and Prognosis. 61
28652957 2017
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Variations for Acute Poststreptococcal Glomerulonephritis

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Expression for Acute Poststreptococcal Glomerulonephritis

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Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.
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Pathways for Acute Poststreptococcal Glomerulonephritis

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Pathways related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Creation of C4 and C2 activators 65
Show member pathways
 11.72 CFH C5 C4BPA C3
2
Immune response Lectin induced complement pathway 23
Show member pathways
 11.55 CFP CFH C5 C4BPA C3
3
Complement Pathway 63
Show member pathways
 11.45 CFP C5 C3
4
Staphylococcus aureus infection 36
11.44 PLG CFH C5 C3
5
Complement and coagulation cascades 36 1
11.39 SERPINF2 PLG CFHR5 CFHR2 CFH C5
6
Pertussis 36
11.38 C5 C4BPA C3
7
Dissolution of Fibrin Clot 65
10.52 SERPINF2 PLG
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GO Terms for Acute Poststreptococcal Glomerulonephritis

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Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 SERPINF2 PLG NPPA EDN1 CFP CFH
2 extracellular region GO:0005576 9.73 SERPINF2 PLG NPPA EDN1 CFP CFHR5
3 protein-containing complex GO:0032991 9.72 NPPA CFHR5 CFHR2 C3 ALB
4 collagen-containing extracellular matrix GO:0062023 9.67 SERPINF2 PLG NPPA CFP
5 platelet alpha granule lumen GO:0031093 9.43 SERPINF2 PLG ALB
6 blood microparticle GO:0072562 9.1 SERPINF2 PLG CFH C4BPA C3 ALB

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.92 CFP CFH C5 C4BPA C3
2 cell surface receptor signaling pathway GO:0007166 9.86 EDNRB EDN1 CD79A C5
3 immune system process GO:0002376 9.85 CFP CFH CD79A C5 C4BPA C3
4 negative regulation of endopeptidase activity GO:0010951 9.79 SERPINF2 C5 C3
5 platelet degranulation GO:0002576 9.76 SERPINF2 PLG ALB
6 cellular protein metabolic process GO:0044267 9.76 PLG NPPA C3 ALB
7 regulation of blood pressure GO:0008217 9.65 NPPA EDNRB EDN1
8 positive regulation of heart rate GO:0010460 9.61 NPPA EDN1
9 fibrinolysis GO:0042730 9.61 SERPINF2 PLG
10 cGMP-mediated signaling GO:0019934 9.6 NPPA EDNRB
11 regulation of pH GO:0006885 9.59 EDNRB EDN1
12 vasoconstriction GO:0042310 9.58 EDNRB EDN1
13 response to muscle stretch GO:0035994 9.57 NPPA EDN1
14 positive regulation of renal sodium excretion GO:0035815 9.55 EDNRB EDN1
15 positive regulation of urine volume GO:0035810 9.54 EDNRB EDN1
16 negative regulation of fibrinolysis GO:0051918 9.51 SERPINF2 PLG
17 cytolysis by host of symbiont cells GO:0051838 9.49 CFHR5 CFHR2
18 complement activation GO:0006956 9.46 CFP CFH C5 C3
19 endothelin receptor signaling pathway GO:0086100 9.43 EDNRB EDN1
20 epithelial fluid transport GO:0042045 9.4 EDNRB EDN1
21 complement activation, alternative pathway GO:0006957 9.35 CFP CFHR5 CFH C5 C3
22 negative regulation of cellular protein metabolic process GO:0032269 9.32 EDNRB EDN1
23 vein smooth muscle contraction GO:0014826 9.26 EDNRB EDN1
24 regulation of complement activation GO:0030449 9.17 CFP CFHR5 CFHR2 CFH C5 C4BPA

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.06 SKA1 SERPINF2 PLG NPPA MYOM2 EDNRB
2 signaling receptor binding GO:0005102 9.35 PLG NPPA EDN1 C5 C3
3 endopeptidase inhibitor activity GO:0004866 8.8 SERPINF2 C5 C3
Sources

Sources for Acute Poststreptococcal Glomerulonephritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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