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MCID: ACT040
MIFTS: 37

Acute Poststreptococcal Glomerulonephritis

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

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MalaCards integrated aliases for Acute Poststreptococcal Glomerulonephritis:

Name: Acute Poststreptococcal Glomerulonephritis 12 55 15
Acute Post-Streptococcal Glomerulonephritis 72
Post-Streptococcal Glomerulonephritis 12

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:14064
NCIt 50 C35443
SNOMED-CT 68 68544003
UMLS 72 C0403414
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Summaries for Acute Poststreptococcal Glomerulonephritis

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MalaCards based summary : Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to rapidly progressive glomerulonephritis and pulmonary edema. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (Complement Factor Properdin), and among its related pathways/superpathways are Immune response Lectin induced complement pathway and Staphylococcus aureus infection. The drugs Amoxicillin and Cefpodoxime have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and skin, and related phenotypes are cardiovascular system and renal/urinary system

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Related Diseases for Acute Poststreptococcal Glomerulonephritis

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Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 rapidly progressive glomerulonephritis 30.2 PIGN C5
2 pulmonary edema 29.8 NPPA EDN1
3 hemolytic uremic syndrome, atypical 1 29.7 CFP C5
4 liver cirrhosis 29.7 SERPINF2 NPPA EDN1
5 hypertension, essential 29.3 NPPA EDNRB EDN1
6 glomerulonephritis 11.1
7 rheumatic fever 10.6
8 rheumatic fever-related antigen 10.5
9 nephrotic syndrome 10.5
10 complement component 5 deficiency 10.4 CFP C5
11 pharyngitis 10.4
12 purpura 10.4
13 proliferative glomerulonephritis 10.4
14 encephalopathy 10.4
15 complement deficiency 10.3 CFP C5
16 intestinal impaction 10.3 SERPINF2 PLG
17 thrombocytopenia 10.3
18 iga glomerulonephritis 10.3
19 acute kidney failure 10.3
20 mesangial proliferative glomerulonephritis 10.3
21 hemolytic anemia 10.3
22 impetigo 10.3
23 hypertensive encephalopathy 10.3
24 streptococcal group a invasive disease 10.3
25 giant hemangioma 10.3 SERPINF2 PLG
26 intracranial embolism 10.3 SERPINF2 PLG
27 hepatic vascular disease 10.3 PLG EDN1
28 alpha-2-plasmin inhibitor deficiency 10.3 SERPINF2 PLG
29 acute cor pulmonale 10.3 SERPINF2 PLG
30 livedoid vasculitis 10.3 SERPINF2 PLG
31 scabies 10.3
32 seizure disorder 10.3
33 acute pulmonary heart disease 10.2 SERPINF2 PLG
34 erysipelas 10.2
35 hemolytic-uremic syndrome 10.2
36 acute proliferative glomerulonephritis 10.2
37 pyoderma 10.2
38 kidney disease 10.2
39 diffuse alveolar hemorrhage 10.2
40 glomerular disease 10.2
41 thrombotic microangiopathy 10.2
42 malignant hypertension 10.2 NPPA EDN1
43 idiopathic edema 10.2 NPPA EDN1
44 hepatorenal syndrome 10.2 NPPA EDN1
45 deficiency anemia 10.2
46 rheumatic heart disease 10.2
47 visual epilepsy 10.2
48 rheumatic disease 10.2
49 enthesopathy 10.2
50 acute articular rheumatism 10.2

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to Acute Poststreptococcal Glomerulonephritis
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Symptoms & Phenotypes for Acute Poststreptococcal Glomerulonephritis

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MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 CFP EDN1 EDNRB NPPA PLG
2 renal/urinary system MP:0005367 8.92 EDN1 EDNRB NPPA PLG
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Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

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Drugs for Acute Poststreptococcal Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved 26787-78-0 33613
2
Cefpodoxime Approved, Vet_approved 80210-62-4, 82619-04-3 6335986
3 Antibodies
4 Immunoglobulins
5 Vaccines
6 Cefpodoxime proxetil
7 Cephalosporins
8 Anti-Infective Agents, Local
9 Antitubercular Agents
10 Antibiotics, Antitubercular
11 Anti-Infective Agents
12 penicillins
13 Anti-Bacterial Agents
14 Immunologic Factors
15 Complement System Proteins
16 Antistreptolysin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771
2 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) - Part 5: Establishing Natural Age-Related Titers of Antibodies to the J8 Group A Streptococcal Epitope in Fiji Completed NCT00264784
3 Impact of Antibiotic Treatment of Group A Streptococcal Blistering Distal Dactylitis in Children Completed NCT02624882
4 Clinical Spectrum and Outcome of Acute Post Streptococcal Glomerulonephritis in Children . Not yet recruiting NCT03184103
5 The Molecular Epidemiology of Streptococcus Pyogenes Among Children in Leon, Nicaragua Terminated NCT00170521

Search NIH Clinical Center for Acute Poststreptococcal Glomerulonephritis

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Genetic Tests for Acute Poststreptococcal Glomerulonephritis

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Anatomical Context for Acute Poststreptococcal Glomerulonephritis

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MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

41
Kidney, Heart, Skin, Neutrophil, Liver, Endothelial, Monocytes
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Publications for Acute Poststreptococcal Glomerulonephritis

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Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50) (show all 620)
# Title Authors PMID Year
1
Streptococcal zymogen type B induces angiotensin II in mesangial cells and leukocytes. 9 38
19184118 2009
2
Increased IL-6 in supernatant of rat mesangial cell cultures treated with erythrogenic toxin type B and its precursor isolated from nephritogenic streptococci. 9 38
16534181 2006
3
Streptococcal erythrogenic toxin B induces apoptosis and proliferation in human leukocytes. 9 38
11231350 2001
4
Anticardiolipin antibodies in acute poststreptococcal glomerulonephritis and streptococcal impetigo. 9 38
10461035 1999
5
Glomerulonephritis in childhood. 9 38
9204243 1997
6
Decreased platelet counts and decreased platelet serotonin in poststreptococcal nephritis. 9 38
7723894 1995
7
Plasma terminal complement complexes in acute poststreptococcal glomerulonephritis. 9 38
1996575 1991
8
Extrarenal Immune-Mediated Disorders Linked with Acute Poststreptococcal Glomerulonephritis: a Systematic Review. 38
31392657 2019
9
Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis. 38
31399725 2019
10
Post-streptococcal glomerulonephritis: Some reduction in a disease of disparities. 38
30311280 2019
11
Systematic Review of Group A Streptococcal emm Types Associated with Acute Post-Streptococcal Glomerulonephritis. 38
30915958 2019
12
Post-Streptococcal Glomerulonephritis in Two Patients Following Deceased Donor Kidney Transplant. 38
31017877 2019
13
[Zwiększenie częstości zachorowania na ostre popaciorkowcowe kłębuszkowe zapalenie nerek w pierwszej połowie roku 2018 - doświadczenie jednego ośrodka]. 38
30912519 2019
14
[Relapse of acute rheumatism fever associated with acute post-streptococcal glomerulonephritis]. 38
30665782 2019
15
A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why? 38
30760615 2019
16
A Presumed Etiology of Kawasaki Disease Based on Epidemiological Comparison With Infectious or Immune-Mediated Diseases. 38
31165053 2019
17
[Post-streptococcal glomerulonephritis in the south of Tunisia: A 12-year retrospective review]. 38
29735420 2018
18
Acute Post-Streptococcal Glomerulonephritis in the Northern Territory of Australia: A Review of Data from 2009 to 2016 and Comparison with the Literature. 38
30398135 2018
19
Factors associated with treatment outcome of acute post streptococcal glomerulonephritis among patients less than 18 years in Mekelle City, Public Hospitals, North Ethiopia. 38
30285899 2018
20
Outbreak of Glomerulonephritis Caused by Streptococcus zooepidemicus SzPHV5 Type in Monte Santo de Minas, Minas Gerais, Brazil. 38
30068536 2018
21
Nephritis-associated plasmin receptor (NAPlr) positive glomerulonephritis caused by Aggregatibacter actinomycetemcomitans bacteremia: A case report. 38
29578396 2018
22
Role of Steroids in Post-streptococcal Glomerulonephritis Without Crescents on Renal Biopsy. 38
30345206 2018
23
Pediatric post-streptococcal glomerulonephritis: Clinical and laboratory data. 38
29729114 2018
24
Poststreptococcal glomerulonephritis with atypical hemolytic uremic syndrome: An unusual presentation. 38
29970754 2018
25
Anticardiolipin antibodies in concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia: A case report. 38
29557617 2018
26
The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. 38
29269013 2018
27
Acute renal failure with need for renal replacement therapy as a complication of zoonotic S. zooepidemicus infection: case report and review of the literature. 38
28508721 2018
28
Henoch-Schonlein purpura, post-streptococcal glomerulonephritis and acute rheumatic carditis after Group A β-haemolytic streptococcal infection. 38
28162051 2018
29
Posterior Reversible Encephalopathy Syndrome Secondary to Acute PostStreptococcal Glomerulonephritis in a 12-year-old Girl. 38
29290203 2018
30
M protein gene (emm type) analysis of group A Streptococcus isolates recovered during an acute glomerulonephritis outbreak in northern Western Australia. 38
29079005 2017
31
Acute postinfectious glomerulonephritis associated with scabies in the elderly: A case report. 38
28851633 2017
32
Post-infectious glomerulonephritis. 38
28891413 2017
33
Clinical characteristics of hypertensive encephalopathy in pediatric patients. 38
29042869 2017
34
Cardiac status in children with acute poststreptococcal glomerulonephritis. 38
28748885 2017
35
A Retrospective Study of Acute Renal Failure in Children: Its Incidence, Etiology, Complications and Prognosis. 38
28652957 2017
36
Molecular biology of Group A Streptococcus and its implications in vaccine strategies. 38
28681803 2017
37
Clinical development strategy for a candidate group A streptococcal vaccine. 38
28318768 2017
38
Acute rheumatic fever and acute post-streptococcal glomerulonephritis rarely seen together. 38
28102656 2017
39
Multiple Causes of Hyponatremia: A Case Report. 38
28268230 2017
40
Posterior reversible encephalopathy syndrome in children: a case series. 38
28123335 2016
41
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: An uncommon coincidence. 38
27625530 2016
42
Different antibiotic treatments for group A streptococcal pharyngitis. 38
27614728 2016
43
Accelerating the development of a group A Streptococcus vaccine: an urgent public health need. 38
27489799 2016
44
HIT or Miss: The Sequential Diagnostic Approach to Heparin-Induced Thrombocytopenia Illustrated in a Child With Acute Post-Streptococcal Glomerulonephritis. 38
25963179 2016
45
Rationale and design of the African group A streptococcal infection registry: the AFROStrep study. 38
26916694 2016
46
Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab? 38
26798467 2016
47
Temporal Changes in Post-Infectious Glomerulonephritis in Japan (1976-2009). 38
27286043 2016
48
IgA-dominant acute poststreptococcal glomerulonephritis with concomitant rheumatic fever successfully treated with steroids: a case report. 38
26718763 2015
49
[Outcome of rapidly progressive glomerulonephritis post-streptococcal disease in children]. 38
26206771 2015
50
Clinical Characteristics and Outcome of Post-Infectious Glomerulonephritis in Children in Southern India: A Prospective Study. 38
25893528 2015
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Variations for Acute Poststreptococcal Glomerulonephritis

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Expression for Acute Poststreptococcal Glomerulonephritis

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Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.
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Pathways for Acute Poststreptococcal Glomerulonephritis

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Pathways related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Immune response Lectin induced complement pathway 22
Show member pathways
 11.46 CFP C5 C4BPA
2
Staphylococcus aureus infection 37
11.39 PLG C5
3
Endothelins 1
11.09 EDNRB EDN1
4
Complement and coagulation cascades 37 1
11.07 SERPINF2 PLG C5 C4BPA
5
Endothelin Pathways 1
10.85 EDNRB EDN1
6
Prostaglandin Synthesis and Regulation 1
10.73 EDNRB EDN1
7
Dissolution of Fibrin Clot 66
10.07 SERPINF2 PLG
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GO Terms for Acute Poststreptococcal Glomerulonephritis

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Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 SERPINF2 PLG NPPA EDN1 CFP C5
2 blood microparticle GO:0072562 9.43 SERPINF2 PLG C4BPA
3 platelet alpha granule lumen GO:0031093 9.32 SERPINF2 PLG
4 collagen-containing extracellular matrix GO:0062023 9.26 SERPINF2 PLG NPPA CFP
5 extracellular space GO:0005615 9.17 SERPINF2 PLG NPPA EDN1 CFP C5

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.76 EDNRB EDN1 C5
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.6 SERPINF2 EDN1
3 sensory perception of pain GO:0019233 9.59 EDNRB EDN1
4 regulation of sensory perception of pain GO:0051930 9.58 EDNRB EDN1
5 blood vessel morphogenesis GO:0048514 9.57 SERPINF2 EDN1
6 positive regulation of heart rate GO:0010460 9.56 NPPA EDN1
7 fibrinolysis GO:0042730 9.55 SERPINF2 PLG
8 cGMP-mediated signaling GO:0019934 9.54 NPPA EDNRB
9 regulation of complement activation GO:0030449 9.54 CFP C5 C4BPA
10 regulation of pH GO:0006885 9.52 EDNRB EDN1
11 regulation of blood vessel size GO:0050880 9.51 NPPA EDN1
12 vasoconstriction GO:0042310 9.49 EDNRB EDN1
13 response to muscle stretch GO:0035994 9.48 NPPA EDN1
14 positive regulation of urine volume GO:0035810 9.46 EDNRB EDN1
15 positive regulation of renal sodium excretion GO:0035815 9.43 EDNRB EDN1
16 complement activation, alternative pathway GO:0006957 9.4 CFP C5
17 negative regulation of fibrinolysis GO:0051918 9.32 SERPINF2 PLG
18 negative regulation of cellular protein metabolic process GO:0032269 9.26 EDNRB EDN1
19 epithelial fluid transport GO:0042045 9.16 EDNRB EDN1
20 regulation of blood pressure GO:0008217 9.13 NPPA EDNRB EDN1
21 vein smooth muscle contraction GO:0014826 8.62 EDNRB EDN1

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.96 SERPINF2 C5
2 signaling receptor binding GO:0005102 8.92 PLG NPPA EDN1 C5
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Sources for Acute Poststreptococcal Glomerulonephritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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