MCID: ACT079
MIFTS: 38

Acute Proliferative Glomerulonephritis

Categories: Nephrological diseases

Aliases & Classifications for Acute Proliferative Glomerulonephritis

MalaCards integrated aliases for Acute Proliferative Glomerulonephritis:

Name: Acute Proliferative Glomerulonephritis 12 15 70
Acute Glomerulonephritis with Lesion of Proliferative Glomerulonephritis 12
Acute Post-Streptococcal Glomerulonephritis 70

Classifications:



External Ids:

Disease Ontology 12 DOID:13138
ICD9CM 34 580.0
SNOMED-CT 67 197579006
UMLS 70 C0341692 C0403414

Summaries for Acute Proliferative Glomerulonephritis

MalaCards based summary : Acute Proliferative Glomerulonephritis, also known as acute glomerulonephritis with lesion of proliferative glomerulonephritis, is related to proliferative glomerulonephritis and glomerulonephritis. An important gene associated with Acute Proliferative Glomerulonephritis is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Defensins. The drugs Immunologic Factors and Complement System Proteins have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and bone, and related phenotype is immune system.

Wikipedia : 73 Acute proliferative glomerulonephritis is a disorder of the small blood vessels of the kidney. It is a... more...

Related Diseases for Acute Proliferative Glomerulonephritis

Diseases in the Proliferative Glomerulonephritis family:

Acute Proliferative Glomerulonephritis

Diseases related to Acute Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 536)
# Related Disease Score Top Affiliating Genes
1 proliferative glomerulonephritis 31.0 MPO CCL2 C3
2 glomerulonephritis 29.7 PRTN3 NPHS2 NPHS1 MPO CTSG COL4A3
3 kidney disease 29.1 TNF PRTN3 NPHS2 NPHS1 CRP COL4A3
4 allergic cutaneous vasculitis 10.5 PRTN3 MPO
5 acute frontal sinusitis 10.4 PRTN3 MPO
6 autoimmune inner ear disease 10.4 TNF MPO
7 cork-handlers' disease 10.4 CD4 ALB
8 riedel's fibrosing thyroiditis 10.4 CD4 ALB
9 wissler-fanconi syndrome 10.4 PRTN3 CD4
10 near-fatal asthma 10.4 TNF CCL2
11 anca-associated vasculitis 10.4 PRTN3 MPO C3
12 yellow nail syndrome 10.3 CCR6 ALB
13 idiopathic steroid-resistant nephrotic syndrome 10.3 NPHS2 NPHS1 ALB
14 granulomatous myositis 10.3 PRTN3 CD68
15 legume allergy 10.3 ICOSLG CD4 CCR6
16 fruit allergy 10.3 ICOSLG CD4 CCR6
17 immunodeficiency 16 10.3 ICOSLG CD4 CCR6
18 primary thrombocytopenia 10.3 ICOSLG CD4 CCR6
19 blood protein disease 10.3 ICOSLG CCR6 ALB
20 palladium allergic contact dermatitis 10.3 TNF CCL2
21 bacterial esophagitis 10.3 CD68 CD4
22 immunoglobulin alpha deficiency 10.3 ICOSLG CD4 CCR6
23 herpes simplex virus keratitis 10.3 CD4 CCR6 CCL2
24 thrombocytopenia due to platelet alloimmunization 10.3 ICOSLG CD4 CCR6
25 respiratory allergy 10.3 ICOSLG CD4 CCR6
26 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.3 ICOSLG CD4 CCR6
27 t cell deficiency 10.3 ICOSLG CD4 CCR6
28 congenital syphilis 10.3 NPHS2 NPHS1 CD4
29 conjunctivitis 10.3 TNF MPO CCL2
30 pierson syndrome 10.3 NPHS2 NPHS1 COL4A3
31 transverse myelitis 10.3 TNF ICOSLG CCR6
32 myelitis 10.3 TNF ICOSLG CCR6
33 bullous skin disease 10.3 ICOSLG CD4 CCR6
34 immunodeficiency with hyper-igm, type 1 10.3 ICOSLG CD4 CCR6
35 pasteurellosis 10.3 TNF MPO ALB
36 type 1 diabetes mellitus 23 10.3 TNF CD4
37 thrombocytopenic purpura, autoimmune 10.3 ICOSLG CD4 CCR6
38 thymus gland disease 10.3 ICOSLG CD4 CCR6
39 capillary leak syndrome 10.3 ICOSLG C3 ALB
40 parasitic ectoparasitic infectious disease 10.3 CD4 CCR6 ALB
41 posterior uveitis 10.3 TNF ICOSLG CCR6
42 chronic duodenal ileus 10.3 CRP ALB
43 thymus cancer 10.3 ICOSLG CD4 CCR6
44 churg-strauss syndrome 10.3 TNF PRTN3 MPO
45 agammaglobulinemia, x-linked 10.3 ICOSLG CD4 CCR6
46 monoclonal gammopathy of uncertain significance 10.3 TNF ICOSLG CCR6
47 mature t-cell and nk-cell lymphoma 10.3 ICOSLG CD4 CCR6
48 nail-patella syndrome 10.3 NPHS2 NPHS1 COL4A3
49 schistosomiasis 10.3 TNF CCL2 ALB
50 nephrotic syndrome, type 10 10.3 PODXL NPHS2 NPHS1

Comorbidity relations with Acute Proliferative Glomerulonephritis via Phenotypic Disease Network (PDN):


Acute Kidney Failure Chronic Kidney Disease
Deficiency Anemia

Graphical network of the top 20 diseases related to Acute Proliferative Glomerulonephritis:



Diseases related to Acute Proliferative Glomerulonephritis

Symptoms & Phenotypes for Acute Proliferative Glomerulonephritis

MGI Mouse Phenotypes related to Acute Proliferative Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.47 ALB C3 CCL2 CCR6 CD4 CD68

Drugs & Therapeutics for Acute Proliferative Glomerulonephritis

Drugs for Acute Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors
2 Complement System Proteins
3 Antistreptolysin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Spectrum and Outcome of Acute Post Streptococcal Glomerulonephritis in Children . Unknown status NCT03184103
2 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771

Search NIH Clinical Center for Acute Proliferative Glomerulonephritis

Genetic Tests for Acute Proliferative Glomerulonephritis

Anatomical Context for Acute Proliferative Glomerulonephritis

MalaCards organs/tissues related to Acute Proliferative Glomerulonephritis:

40
Kidney, Skin, Bone, Lung, Eye, Lymph Node, Thymus

Publications for Acute Proliferative Glomerulonephritis

Articles related to Acute Proliferative Glomerulonephritis:

(show top 50) (show all 226)
# Title Authors PMID Year
1
Myocarditis and intracardiac thrombus due to Henoch-Schönlein purpura: case report and literature review. 61
32789615 2021
2
Acute post-streptococcal glomerulonephritis: analysis of the pathogenesis. 61
33030969 2020
3
Incidence of Acute Post-Streptococcal Glomerulonephritis in Hawai'i and Factors Affecting Length of Hospitalization. 61
32432220 2020
4
[CORRELATION ANALYSIS BETWEEN CLINICO-LABORATORY AND INSTRUMENTAL INDICATORS OF CARDIAC INVOVLVEMENT IN YOUNG ADULTS SUFFERING FROM ACUTE POST-STREPTOCOCCAL GLOMERULONEPHRITIS WITH ACUTE RENO-CARDIAL SYNDROME]. 61
32535574 2020
5
Rare case of post-varicella membranoproliferative glomerulonephritis presenting with massive proteinuria. 61
32169983 2020
6
Skin infections in Australian Aboriginal children: a narrative review. 61
31630410 2020
7
Acute post-streptococcal glomerulonephritis in Central Australia. 61
31659821 2020
8
Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis. 61
31399725 2020
9
Clinical Profile and Immediate Outcome of Children Admitted With Acute Glomerulonephritis in Pediatrics Department of A Tertiary Level Hospital. 61
31915329 2020
10
Therapeutic potential of medicinal plants for the management of scabies. 61
31830356 2020
11
Case Report: Concurrent Rheumatic Fever and Acute Post-Streptococcal Glomerulonephritis in a High-Burden Setting. 61
31516109 2019
12
High burden and seasonal variation of paediatric scabies and pyoderma prevalence in The Gambia: A cross-sectional study. 61
31609963 2019
13
Post-streptococcal glomerulonephritis: Some reduction in a disease of disparities. 61
30311280 2019
14
Systematic Review of Group A Streptococcal emm Types Associated with Acute Post-Streptococcal Glomerulonephritis. 61
30915958 2019
15
[Relapse of acute rheumatism fever associated with acute post-streptococcal glomerulonephritis]. 61
30665782 2019
16
Acute Post-Streptococcal Glomerulonephritis in the Northern Territory of Australia: A Review of Data from 2009 to 2016 and Comparison with the Literature. 61
30398135 2018
17
Factors associated with treatment outcome of acute post streptococcal glomerulonephritis among patients less than 18 years in Mekelle City, Public Hospitals, North Ethiopia. 61
30285899 2018
18
Nephritis-associated plasmin receptor (NAPlr) positive glomerulonephritis caused by Aggregatibacter actinomycetemcomitans bacteremia: A case report. 61
29578396 2018
19
Pediatric post-streptococcal glomerulonephritis: Clinical and laboratory data. 61
29729114 2018
20
Anticardiolipin antibodies in concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia: A case report. 61
29557617 2018
21
Association of hemophagocytic lymphohistiocytosis with kidney lesions in acute African swine fever virus infection 61
30738418 2018
22
Acute glomerulonephritis with large confluent IgA-dominant deposits associated with liver cirrhosis. 61
29634718 2018
23
M protein gene (emm type) analysis of group A Streptococcus isolates recovered during an acute glomerulonephritis outbreak in northern Western Australia. 61
29079005 2017
24
A Retrospective Study of Acute Renal Failure in Children: Its Incidence, Etiology, Complications and Prognosis. 61
28652957 2017
25
Acute rheumatic fever and acute post-streptococcal glomerulonephritis rarely seen together. 61
28102656 2017
26
Changing trends in pediatric renal biopsies: analysis of pediatric renal biopsies in national nephrology registry data. 61
27430296 2016
27
Accelerating the development of a group A Streptococcus vaccine: an urgent public health need. 61
27489799 2016
28
Factors Associated With Pathogenicity of Anti-Glomerular Basal Membrane Antibodies: A Case Report. 61
27175692 2016
29
HIT or Miss: The Sequential Diagnostic Approach to Heparin-Induced Thrombocytopenia Illustrated in a Child With Acute Post-Streptococcal Glomerulonephritis. 61
25963179 2016
30
Rationale and design of the African group A streptococcal infection registry: the AFROStrep study. 61
26916694 2016
31
Posterior Reversible Encephelopathy Syndrome in Post-Streptococcal Glomerulonephritis. 61
26710406 2015
32
Posterior Reversible Encephalopathy Syndrome and Acute Post-Streptococcal Glomerulonephritis Mimicking Breakthrough Seizures. 61
26294945 2015
33
A case of acute post-streptococcal glomerulonephritis that developed posterior reversible encephalopathy syndrome. 61
26078688 2014
34
[Epidemiology of Streptococcus pyogenes infections in developing countries]. 61
25456683 2014
35
Post-streptococcal glomerulonephritis leading to posterior reversible encephalopathy syndrome: a case report. 61
25218027 2014
36
Streptococcal infection as possible trigger for dense deposit disease (C3 glomerulopathy). 61
24384791 2014
37
Prognosis of acute post-streptococcal glomerulonephritis in Sudanese children. 61
25366505 2014
38
Severe hypoalphalipoproteinaemia in a child with acute post-streptococcal glomerulonephritis (APSGN). 61
24194163 2013
39
The renin-angiotensin system from conception to old age: the good, the bad and the ugly. 61
24164175 2013
40
Glomerulopathy in a patient with sarcocystis infestation. 61
24152512 2013
41
A rare case of juvenile acute non-proliferative glomerulonephritis with a 6-year follow-up experience. 61
22297470 2013
42
Post-streptococcal glomerulonephritis: not an extinct disease! 61
24156223 2013
43
Severe acute post-streptococcal glomerulonephritis in an infant. 61
23640628 2013
44
The spectrum of glomerular diseases on renal biopsy: data from a single tertiary center in oman. 61
23772291 2013
45
Group A streptococcal vaccines: paving a path for accelerated development. 61
23598485 2013
46
Risk factors and outcome of atypical acute post-streptococcal glomerulonephritis in pediatrics. 61
23691638 2013
47
[Peculiarities of epidemiology of chronic tonsillitis under current conditions of providing specialized aid to the patients presenting with ENT diseases]. 61
23887365 2013
48
Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis. 61
23372691 2013
49
Acute post-streptococcal glomerulonephritis with acute kidney injury in nephrotic syndrome with the glomerular deposition of nephritis-associated plasmin receptor antigen. 61
24042518 2013
50
Neonatal Fc receptor stimulation induces ubiquitin c-terminal hydrolase-1 overexpression in podocytes through activation of p38 mitogen-activated protein kinase. 61
22406365 2012

Variations for Acute Proliferative Glomerulonephritis

Expression for Acute Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Acute Proliferative Glomerulonephritis.

Pathways for Acute Proliferative Glomerulonephritis

GO Terms for Acute Proliferative Glomerulonephritis

Cellular components related to Acute Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.27 TNF PRTN3 PODXL PLA2R1 NPHS2 NPHS1
2 extracellular region GO:0005576 10.11 TNF PRTN3 PLA2R1 MPO CTSG CRP
3 extracellular exosome GO:0070062 10.06 PRTN3 PODXL NPHS2 NPHS1 MPO LAMP2
4 cell surface GO:0009986 9.88 TNF PLA2R1 CTSG CD4 CCR6 C3
5 membrane raft GO:0045121 9.63 TNF PRTN3 PODXL NPHS2 LAMP2 CD4
6 azurophil granule membrane GO:0035577 9.61 LAMP2 CD68 AZU1
7 azurophil granule GO:0042582 9.48 MPO AZU1
8 slit diaphragm GO:0036057 9.43 PODXL NPHS2 NPHS1
9 extracellular space GO:0005615 9.4 TNF PRTN3 PODXL MPO LAMP2 CTSG
10 azurophil granule lumen GO:0035578 9.35 PRTN3 MPO CTSG C3 AZU1

Biological processes related to Acute Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 TNF CRP CCL2 C3 AZU1
2 defense response to Gram-negative bacterium GO:0050829 9.73 CTSG CD4 AZU1
3 positive regulation of protein kinase activity GO:0045860 9.65 TNF CD4 AZU1
4 antimicrobial humoral response GO:0019730 9.63 PRTN3 CTSG AZU1
5 cellular response to lipopolysaccharide GO:0071222 9.62 TNF CTSG CD68 CCL2
6 humoral immune response GO:0006959 9.61 TNF CCR6 CCL2
7 glomerular basement membrane development GO:0032836 9.55 NPHS1 COL4A3
8 glomerular visceral epithelial cell development GO:0072015 9.54 PODXL NPHS1
9 negative regulation of lipid storage GO:0010888 9.52 TNF CRP
10 establishment of protein localization to organelle GO:0072594 9.51 LAMP2 CD68
11 endothelial cell apoptotic process GO:0072577 9.49 TNF COL4A3
12 immune response GO:0006955 9.43 TNF CTSG CD4 CCR6 CCL2 C3
13 positive regulation of apoptotic cell clearance GO:2000427 9.37 CCL2 C3
14 positive regulation of phagocytosis GO:0050766 9.33 TNF C3 AZU1
15 cellular extravasation GO:0045123 9.26 TNF AZU1
16 neutrophil degranulation GO:0043312 9.17 PRTN3 MPO LAMP2 CTSG CD68 C3

Molecular functions related to Acute Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.02 PRTN3 ICOSLG CD4 CCL2 C3
2 toxic substance binding GO:0015643 8.96 AZU1 ALB

Sources for Acute Proliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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