MCID: ACT080
MIFTS: 28

Acute Pulmonary Heart Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Acute Pulmonary Heart Disease

MalaCards integrated aliases for Acute Pulmonary Heart Disease:

Name: Acute Pulmonary Heart Disease 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:8514
ICD9CM 36 415
SNOMED-CT 69 67189007
UMLS 74 C0155671

Summaries for Acute Pulmonary Heart Disease

MalaCards based summary : Acute Pulmonary Heart Disease is related to ligneous conjunctivitis and cardiogenic shock. An important gene associated with Acute Pulmonary Heart Disease is POR (Cytochrome P450 Oxidoreductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Levodopa and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, and related phenotypes are cardiovascular system and cellular

Related Diseases for Acute Pulmonary Heart Disease

Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Acute Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 ligneous conjunctivitis 10.4 PLAT PLG
2 cardiogenic shock 10.3 NPPB PLAT
3 anterolateral myocardial infarction 10.3 NPPB PLAT
4 central retinal artery occlusion 10.3 PLAT PLG
5 intestinal impaction 10.3 PLG SERPINF2
6 alpha-2-plasmin inhibitor deficiency 10.3 PLG SERPINF2
7 occlusion precerebral artery 10.3 PLAT PLG
8 giant hemangioma 10.3 PLG SERPINF2
9 basilar artery occlusion 10.3 PLAT PLG
10 acute poststreptococcal glomerulonephritis 10.3 PLG SERPINF2
11 platelet aggregation, spontaneous 10.3 PLAT SERPINF2
12 korean hemorrhagic fever 10.3 PLG SERPINF2
13 marantic endocarditis 10.3 PLAT SERPINF2
14 intermediate coronary syndrome 10.2 PLAT PLG
15 fibrinolytic defect 10.2 PLAT SERPINE1
16 inferior myocardial infarction 10.2 NPPB PLAT PLG
17 pregnancy adenoma 10.2 PLAT SERPINF2
18 tuberculous empyema 10.2 PLG SERPINE1
19 argentine hemorrhagic fever 10.2 PLAT SERPINE1
20 central serous chorioretinopathy 10.2 PLAT SERPINE1
21 pulmonary artery disease 10.2 PLAT PLG
22 blue toe syndrome 10.2 PLG SERPINE1
23 carotid artery thrombosis 10.2 PLAT SERPINE1
24 dysbaric osteonecrosis 10.2 PLG SERPINE1
25 angina pectoris 10.2 NPPB PLAT SERPINF2
26 intracranial embolism 10.2 PLAT PLG SERPINF2
27 pulmonary embolism and infarction 10.1 ADAM17 WDFY2
28 lemierre's syndrome 10.1 PLG SERPINE1
29 factor xiii deficiency 10.1 SERPINE1 SERPINF2
30 coronary thrombosis 10.1 PLAT SERPINE1
31 hepatic veno-occlusive disease 10.1 PLAT PLG SERPINE1
32 carotid artery dissection 10.1 PLAT PLG
33 coronary heart disease 1 10.1 NPPB PLAT SERPINE1
34 chronic venous insufficiency 10.0 PLAT SERPINE1
35 livedoid vasculitis 10.0 PLG SERPINE1 SERPINF2
36 plasminogen activator inhibitor-1 deficiency 10.0 PLAT SERPINE1 SERPINF2
37 venous insufficiency 10.0 PLAT SERPINE1
38 thrombophlebitis 10.0 PLAT SERPINE1 SERPINF2
39 tricuspid valve insufficiency 10.0 NPPB PDZK1IP1
40 disseminated intravascular coagulation 10.0 PLAT SERPINE1 SERPINF2
41 hemorrhagic disease 10.0 PLAT SERPINE1 SERPINF2
42 tricuspid valve disease 10.0 NPPB PDZK1IP1
43 hepatic vascular disease 10.0 ADAM17 PLG SERPINE1
44 mitral valve insufficiency 9.9 NPPB PDZK1IP1
45 arteries, anomalies of 9.9 NPPB PLAT PLG SERPINE1
46 coronary artery anomaly 9.9 NPPB PLAT PLG SERPINE1
47 brachial plexus lesion 9.9 CAMP WDFY2
48 pulmonary embolism 9.9 NPPB PLAT SERPINE1 SERPINF2
49 thrombophilia due to activated protein c resistance 9.9 PLAT PLG SERPINE1 SERPINF2
50 stroke, ischemic 9.8 PLAT PLG SERPINE1 SERPINF2

Graphical network of the top 20 diseases related to Acute Pulmonary Heart Disease:



Diseases related to Acute Pulmonary Heart Disease

Symptoms & Phenotypes for Acute Pulmonary Heart Disease

MGI Mouse Phenotypes related to Acute Pulmonary Heart Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 ADAM17 CAST PLAT PLG POR SERPINE1
2 cellular MP:0005384 9.23 ADAM17 CAMP CAST PIWIL2 PLAT PLG

Drugs & Therapeutics for Acute Pulmonary Heart Disease

Drugs for Acute Pulmonary Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levodopa Approved 59-92-7 6047
2
Dopamine Approved 62-31-7, 51-61-6 681
3
Cabergoline Approved 81409-90-7 54746
4
Warfarin Approved 81-81-2 54678486 6691
5
Serine Approved, Nutraceutical 56-45-1 5951
6
Dabigatran Investigational 211914-51-1
7 Cardiotonic Agents
8 Sympathomimetics
9 Protective Agents
10 Peripheral Nervous System Agents
11 Neurotransmitter Agents
12 Dopamine agonists
13 Dopamine Agents
14 Autonomic Agents
15
protease inhibitors
16 Anticoagulants
17 HIV Protease Inhibitors
18 Antithrombin III
19 Antithrombins
20 Serine Proteinase Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
2 The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage Completed NCT02061748 Observational

Search NIH Clinical Center for Acute Pulmonary Heart Disease

Genetic Tests for Acute Pulmonary Heart Disease

Anatomical Context for Acute Pulmonary Heart Disease

MalaCards organs/tissues related to Acute Pulmonary Heart Disease:

42
Heart

Publications for Acute Pulmonary Heart Disease

Variations for Acute Pulmonary Heart Disease

Expression for Acute Pulmonary Heart Disease

Search GEO for disease gene expression data for Acute Pulmonary Heart Disease.

Pathways for Acute Pulmonary Heart Disease

Pathways related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 PLAT PLG SERPINE1 SERPINF2 VCL
2
Show member pathways
12.53 ADAM17 PLAT PLG SERPINE1
3
Show member pathways
12.36 ADAM17 CAST PLG SERPINE1
4
Show member pathways
11.94 PLAT PLG SERPINE1
5
Show member pathways
11.76 PLAT PLG SERPINE1 SERPINF2
6 11.63 PLG SERPINE1 VCL
7 11.6 PLAT PLG SERPINE1 SERPINF2
8 11.28 PLAT PLG SERPINE1
9 10.49 ADAM17 PLAT PLG
10 10.04 PLAT PLG SERPINE1 SERPINF2

GO Terms for Acute Pulmonary Heart Disease

Cellular components related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CAMP NPPB PLAT PLG SERPINE1 SERPINF2
2 extracellular region GO:0005576 9.8 CAMP NPPB PLAT PLG SERPINE1 SERPINF2
3 extracellular exosome GO:0070062 9.7 CAMP PDZK1IP1 PLAT PLG SERPINE1 SERPINF2
4 cell surface GO:0009986 9.67 ADAM17 PLAT PLG SERPINF2
5 collagen-containing extracellular matrix GO:0062023 9.26 PLAT PLG SERPINE1 SERPINF2
6 platelet alpha granule lumen GO:0031093 8.8 PLG SERPINE1 SERPINF2

Biological processes related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of peptidase activity GO:0010466 9.5 CAST SERPINE1 SERPINF2
2 platelet degranulation GO:0002576 9.46 PLG SERPINE1 SERPINF2 VCL
3 negative regulation of plasminogen activation GO:0010757 9.26 SERPINE1 SERPINF2
4 negative regulation of fibrinolysis GO:0051918 9.13 PLG SERPINE1 SERPINF2
5 fibrinolysis GO:0042730 8.92 PLAT PLG SERPINE1 SERPINF2

Molecular functions related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.46 NPPB PLAT PLG SERPINE1
2 endopeptidase inhibitor activity GO:0004866 9.26 CAST SERPINF2
3 peptidase inhibitor activity GO:0030414 9.13 CAST SERPINE1 SERPINF2
4 protease binding GO:0002020 8.8 CAST SERPINE1 SERPINF2

Sources for Acute Pulmonary Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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