Acute Pulmonary Heart Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Acute Pulmonary Heart Disease

MalaCards integrated aliases for Acute Pulmonary Heart Disease:

Name: Acute Pulmonary Heart Disease ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8514

ICD9CM ³⁴ 415

SNOMED-CT ⁶⁷ 155324005

UMLS ⁷¹ C0155671

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Summaries for Acute Pulmonary Heart Disease

MalaCards based summary : Acute Pulmonary Heart Disease is related to pulmonary embolism and thrombophilia due to thrombin defect. An important gene associated with Acute Pulmonary Heart Disease is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Folate Metabolism and Formation of Fibrin Clot (Clotting Cascade). Affiliated tissues include heart, and related phenotypes are muscle and respiratory system

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Related Diseases for Acute Pulmonary Heart Disease

Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Acute Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)

#	Related Disease	Score	Top Affiliating Genes
1	pulmonary embolism	30.1	PLAT NPPB F3 F2
2	thrombophilia due to thrombin defect	29.9	PLAT F3 F2
3	heart disease	29.0	REN PLAT NPPB F3 F2
4	acute cor pulmonale	27.7	TSPAN15 REN PLG PLAT NPR2 NPPB
5	lujo hemorrhagic fever	10.3	NPPB F3
6	medulloadrenal hyperfunction	10.3	PLG F3
7	cardiogenic shock	10.2	PLAT NPPB
8	basal ganglia cerebrovascular disease	10.2	PLG PLAT
9	anterolateral myocardial infarction	10.2	PLAT NPPB
10	ligneous conjunctivitis	10.2	PLG PLAT
11	leech infestation	10.2	PLG F3
12	basilar artery insufficiency	10.2	PLG PLAT
13	retinal artery occlusion	10.2	PLG F2
14	brain stem infarction	10.2	PLG PLAT
15	vertebral artery occlusion	10.2	PLG PLAT
16	plasminogen deficiency, type i	10.2	PLG PLAT
17	conversion disorder	10.2	PLG PLAT
18	anterior spinal artery syndrome	10.2	PLG F2
19	retinal vein occlusion	10.2	F3 F2
20	perforated corneal ulcer	10.2	PLG PLAT
21	hereditary angioedema with normal c1inh	10.2	PLG PLAT
22	achenbach syndrome	10.2	F3 F2
23	thoracic outlet syndrome	10.2	PLG F2
24	middle cerebral artery infarction	10.2	PLG PLAT
25	renal pelvis squamous cell carcinoma	10.2	F3 F2
26	livedoid vasculitis	10.2	PLG F2
27	kidney cortex necrosis	10.2	PLG F2
28	synovial angioma	10.2	F3 F2
29	papillary adenofibroma	10.2	F3 F2
30	emphysematous cholecystitis	10.2	F3 F2
31	giant hemangioma	10.2	F3 F2
32	hemopneumothorax	10.2	F3 F2
33	dic in newborn	10.2	F3 F2
34	ankylosing spondylitis 1	10.2	F3 F2
35	waterhouse-friderichsen syndrome	10.2	F3 F2
36	epidural abscess	10.2	F3 F2
37	lemierre's syndrome	10.2	F3 F2
38	branch retinal artery occlusion	10.2	PLG F2
39	gastric hemangioma	10.2	F3 F2
40	hepatic infarction	10.2	F3 F2
41	splenic abscess	10.2	F3 F2
42	qualitative platelet defect	10.2	F3 F2
43	mediastinitis	10.2	F3 F2
44	cerebral sinovenous thrombosis	10.2	F3 F2
45	carotid artery occlusion	10.2	PLG PLAT
46	pleural empyema	10.2	PLG F2
47	prothrombin deficiency	10.2	F3 F2
48	intracranial hypotension	10.2	F3 F2
49	acquired von willebrand syndrome	10.2	F3 F2
50	active peptic ulcer disease	10.2	F3 F2

Graphical network of the top 20 diseases related to Acute Pulmonary Heart Disease:

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Symptoms & Phenotypes for Acute Pulmonary Heart Disease

MGI Mouse Phenotypes related to Acute Pulmonary Heart Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	9.35	F2 F3 NPR2 PLAT REN
2	respiratory system	MP:0005388	9.02	F2 F3 NPR2 PLAT PLG

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Drugs & Therapeutics for Acute Pulmonary Heart Disease

Search Clinical Trials , NIH Clinical Center for Acute Pulmonary Heart Disease

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Genetic Tests for Acute Pulmonary Heart Disease

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Anatomical Context for Acute Pulmonary Heart Disease

MalaCards organs/tissues related to Acute Pulmonary Heart Disease:

⁴⁰

Heart

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Publications for Acute Pulmonary Heart Disease

Articles related to Acute Pulmonary Heart Disease:

(show all 16)

#	Title	Authors	PMID	Year
1	[Acute pulmonary heart disease caused by pulmonary artery embolism]. ⁶¹	Heintzen MP...Strauer BE	10429913	1999
2	[The value of transesophageal echocardiography for the diagnosis of pulmonary embolism with acute pulmonary heart disease]. ⁶¹	Antakly-Hanon Y...Dubourg O	9749175	1998
3	[Massive pulmonary artery embolism complicated by acute pulmonary heart disease]. ⁶¹	Kober J...Pawlicka L	9181893	1996
4	[Structural and metabolic changes in the contractile myocardium in experimental acute pulmonary heart disease of vascular origin]. ⁶¹	Vinogradov SA...Kolbasin PN	7159237	1982
5	[Acute pulmonary heart disease in a person with chronic bronchopneumopathy and secondary heart disease. Uhlenbruck's syndrome]. ⁶¹	Chini V	4693710	1973
6	[Acute pulmonary heart disease in resuscitation: case reports]. ⁶¹	Castelli E...Mastrorilli M	4807138	1973
7	[A case of intermittent and transitory complete right branch block in embolic acute pulmonary heart disease]. ⁶¹	Warembourg H...Peltier JM	5138704	1971
8	[Acute pulmonary heart disease induced by repeated pulmonary embolisms. Embolectomy under extracorporeal circulation]. ⁶¹	Lemoine G...Mathey J	5778506	1969
9	[ACUTE PULMONARY HEART DISEASE DUE TO AMNIOTIC EMBOLISM. EXPERIMENTAL STUDY]. ⁶¹	MOINE C...MARION P	14289703	1965
10	[ACUTE PULMONARY HEART DISEASE. II. PULMONARY EMBOLISM]. ⁶¹	ERNST S	14251093	1964
11	[Various aspects of acute pulmonary heart disease caused by thromboembolism; doctrinal concept and antecedents]. ⁶¹	SORRIBES-SANTAMARIA V	13358395	1956
12	[Pulmonary embolism and acute pulmonary heart disease; study of the syndrome and analysis of an observation]. ⁶¹	BEAUCHESNE A	13308177	1955
13	[Acute pulmonary heart disease]. ⁶¹	FAIVRE G	14359694	1955
14	[Surgical indications in acute pulmonary heart disease caused by pulmonary embolism]. ⁶¹	TOURNIAIRE A...DEYRIEUX F	13195717	1954
15	[Study on a cardiac output in acute pulmonary heart disease]. ⁶¹	FAIVRE G...HUEBER J	13178378	1954
16	[Acute pulmonary heart disease in serious asthma; therapy and cure]. ⁶¹	DUSSERT A	13226252	1954

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Genes for Acute Pulmonary Heart Disease

Genes related to Acute Pulmonary Heart Disease (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NPPB	Natriuretic Peptide B	Protein Coding	5.4	DISEASES inferred ¹⁵
2	PLG	Plasminogen	Protein Coding	5.34	DISEASES inferred ¹⁵
3	F3	Coagulation Factor III, Tissue Factor	Protein Coding	5.2	DISEASES inferred ¹⁵
4	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	4.93	DISEASES inferred ¹⁵
5	F2	Coagulation Factor II, Thrombin	Protein Coding	4.72	DISEASES inferred ¹⁵
6	TSPAN15	Tetraspanin 15	Protein Coding	4.61	DISEASES inferred ¹⁵
7	NPR2	Natriuretic Peptide Receptor 2	Protein Coding	4.5	DISEASES inferred ¹⁵
8	REN	Renin	Protein Coding	4.5	DISEASES inferred ¹⁵
9	KRTAP1-1	Keratin Associated Protein 1-1	Protein Coding	4.49	DISEASES inferred ¹⁵

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Variations for Acute Pulmonary Heart Disease

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Expression for Acute Pulmonary Heart Disease

Search GEO for disease gene expression data for Acute Pulmonary Heart Disease.

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Pathways for Acute Pulmonary Heart Disease

Pathways related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.88	PLG PLAT F2
2	Formation of Fibrin Clot (Clotting Cascade) ⁶⁵ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁴ Common Pathway of Fibrin Clot Formation ⁶⁵ Extrinsic Pathway of Fibrin Clot Formation ⁶⁵ Extrinsic Prothrombin Activation Pathway ⁶³ Intrinsic Pathway of Fibrin Clot Formation ⁶⁵	11.46	PLG PLAT F3 F2
3	Cell adhesion_Plasmin signaling ²³	11.15	PLG PLAT
4	amb2 Integrin signaling ¹	11.11	PLG PLAT
5	Complement and coagulation cascades ³⁶ ¹	11.09	PLG PLAT F3 F2
6	Syndecan-4-mediated signaling events ¹	10.9	PLG F2
7	A-beta Pathways: Plaque Formation and APP Metabolism ⁶⁴	10.68	PLG PLAT
8	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁵	10.58	PLG F2
9	Dissolution of Fibrin Clot ⁶⁵	10.27	PLG PLAT

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GO Terms for Acute Pulmonary Heart Disease

Cellular components related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.73	REN PLG PLAT NPPB F3 F2
2	cell surface	GO:0009986	9.46	TSPAN15 PLG PLAT F3
3	extracellular space	GO:0005615	9.43	REN PLG PLAT NPPB F3 F2
4	collagen-containing extracellular matrix	GO:0062023	8.92	PLG PLAT F3 F2

Biological processes related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:0006508	9.78	REN PLG PLAT F2
2	cellular protein metabolic process	GO:0044267	9.67	TSPAN15 PLG F2
3	negative regulation of proteolysis	GO:0045861	9.46	PLAT F2
4	cGMP-mediated signaling	GO:0019934	9.43	NPR2 NPPB
5	regulation of blood pressure	GO:0008217	9.43	REN NPR2 NPPB
6	cGMP biosynthetic process	GO:0006182	9.4	NPR2 NPPB
7	negative regulation of fibrinolysis	GO:0051918	9.37	PLG F2
8	hemostasis	GO:0007599	9.33	PLG F3 F2
9	receptor guanylyl cyclase signaling pathway	GO:0007168	9.32	NPR2 NPPB
10	blood coagulation	GO:0007596	9.26	PLG PLAT F3 F2
11	fibrinolysis	GO:0042730	8.8	PLG PLAT F2

Molecular functions related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidase activity	GO:0008233	9.56	REN PLG PLAT F2
2	serine-type peptidase activity	GO:0008236	9.33	PLG PLAT F2
3	serine-type endopeptidase activity	GO:0004252	9.26	PLG PLAT F3 F2
4	signaling receptor binding	GO:0005102	9.02	REN PLG PLAT NPPB F2

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Sources for Acute Pulmonary Heart Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia