Acute Pulmonary Heart Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Acute Pulmonary Heart Disease

MalaCards integrated aliases for Acute Pulmonary Heart Disease:

Name: Acute Pulmonary Heart Disease ¹² ¹⁵ ⁷²

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8514

ICD9CM ³⁵ 415

SNOMED-CT ⁶⁸ 67189007

UMLS ⁷² C0155671

Sources

Summaries for Acute Pulmonary Heart Disease

MalaCards based summary : Acute Pulmonary Heart Disease is related to pulmonary embolism and acute cor pulmonale. An important gene associated with Acute Pulmonary Heart Disease is POR (Cytochrome P450 Oxidoreductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. Affiliated tissues include heart, and related phenotype is cardiovascular system.

Sources

Related Diseases for Acute Pulmonary Heart Disease

Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Acute Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)

#	Related Disease	Score	Top Affiliating Genes
1	pulmonary embolism	29.4	SERPINF2 SERPINE1 PLAT NPPB
2	acute cor pulmonale	25.5	VCL SERPINF2 SERPINE1 POR PLG PLAT
3	hemopericardium	10.5	SLC22A12 PLG
4	cardiogenic shock	10.5	PLAT NPPB
5	anterolateral myocardial infarction	10.5	PLAT NPPB
6	ligneous conjunctivitis	10.5	PLG PLAT
7	central retinal artery occlusion	10.4	PLG PLAT
8	occlusion precerebral artery	10.4	PLG PLAT
9	basilar artery occlusion	10.4	PLG PLAT
10	intermediate coronary syndrome	10.3	PLG PLAT
11	intestinal impaction	10.3	SERPINF2 PLG
12	giant hemangioma	10.3	SERPINF2 PLG
13	alpha-2-plasmin inhibitor deficiency	10.3	SERPINF2 PLG
14	pulmonary artery disease	10.3	PLG PLAT
15	tricuspid valve insufficiency	10.3	PDZK1IP1 NPPB
16	heart disease	10.3
17	acute poststreptococcal glomerulonephritis	10.3	SERPINF2 PLG
18	korean hemorrhagic fever	10.3	SERPINF2 PLG
19	tricuspid valve disease	10.3	PDZK1IP1 NPPB
20	platelet aggregation, spontaneous	10.2	SERPINF2 PLAT
21	inferior myocardial infarction	10.2	PLG PLAT NPPB
22	marantic endocarditis	10.2	SERPINF2 PLAT
23	tuberculous empyema	10.2	SERPINE1 PLG
24	fibrinolytic defect	10.2	SERPINE1 PLAT
25	blue toe syndrome	10.2	SERPINE1 PLG
26	mitral valve insufficiency	10.2	PDZK1IP1 NPPB
27	carotid artery dissection	10.2	PLG PLAT
28	central serous chorioretinopathy	10.2	SERPINE1 PLAT
29	argentine hemorrhagic fever	10.2	SERPINE1 PLAT
30	pregnancy adenoma	10.2	SERPINF2 PLAT
31	dysbaric osteonecrosis	10.2	SERPINE1 PLG
32	carotid artery thrombosis	10.1	SERPINE1 PLAT
33	lemierre's syndrome	10.1	SERPINE1 PLG
34	hepatic vascular disease	10.1	SERPINE1 PLG
35	coronary thrombosis	10.0	SERPINE1 PLAT
36	angina pectoris	10.0	SERPINF2 PLAT NPPB
37	intracranial embolism	10.0	SERPINF2 PLG PLAT
38	chronic venous insufficiency	10.0	SERPINE1 PLAT
39	heart valve disease	10.0	PDZK1IP1 NPPB
40	factor xiii deficiency	10.0	SERPINF2 SERPINE1
41	venous insufficiency	9.9	SERPINE1 PLAT
42	hepatic veno-occlusive disease	9.9	SERPINE1 PLG PLAT
43	vein disease	9.9	SERPINE1 PLG PLAT
44	coronary heart disease 1	9.9	SERPINE1 PLAT NPPB
45	myoma	9.8
46	afibrinogenemia, congenital	9.8	SERPINF2 PLAT
47	livedoid vasculitis	9.8	SERPINF2 SERPINE1 PLG
48	plasminogen activator inhibitor-1 deficiency	9.7	SERPINF2 SERPINE1 PLAT
49	thrombophlebitis	9.7	SERPINF2 SERPINE1 PLAT
50	disseminated intravascular coagulation	9.7	SERPINF2 SERPINE1 PLAT

Graphical network of the top 20 diseases related to Acute Pulmonary Heart Disease:

Sources

Symptoms & Phenotypes for Acute Pulmonary Heart Disease

MGI Mouse Phenotypes related to Acute Pulmonary Heart Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.17	CAST PLAT PLG POR SERPINE1 SLC22A12

Sources

Drugs & Therapeutics for Acute Pulmonary Heart Disease

Search Clinical Trials , NIH Clinical Center for Acute Pulmonary Heart Disease

Sources

Genetic Tests for Acute Pulmonary Heart Disease

Sources

Anatomical Context for Acute Pulmonary Heart Disease

MalaCards organs/tissues related to Acute Pulmonary Heart Disease:

⁴¹

Heart

Sources

Publications for Acute Pulmonary Heart Disease

Articles related to Acute Pulmonary Heart Disease:

(show all 16)

#	Title	Authors	PMID	Year
1	[Acute pulmonary heart disease caused by pulmonary artery embolism]. ³⁸	Heintzen MP...Strauer BE	10429913	1999
2	[The value of transesophageal echocardiography for the diagnosis of pulmonary embolism with acute pulmonary heart disease]. ³⁸	Antakly-Hanon Y...Dubourg O	9749175	1998
3	[Massive pulmonary artery embolism complicated by acute pulmonary heart disease]. ³⁸	Kober J...Pawlicka L	9181893	1996
4	[Structural and metabolic changes in the contractile myocardium in experimental acute pulmonary heart disease of vascular origin]. ³⁸	Vinogradov SA...Kolbasin PN	7159237	1982
5	[Acute pulmonary heart disease in a person with chronic bronchopneumopathy and secondary heart disease. Uhlenbruck's syndrome]. ³⁸	Chini V	4693710	1973
6	[Acute pulmonary heart disease in resuscitation: case reports]. ³⁸	Castelli E...Mastrorilli M	4807138	1973
7	[A case of intermittent and transitory complete right branch block in embolic acute pulmonary heart disease]. ³⁸	Warembourg H...Peltier JM	5138704	1971
8	[Acute pulmonary heart disease induced by repeated pulmonary embolisms. Embolectomy under extracorporeal circulation]. ³⁸	Lemoine G...Mathey J	5778506	1969
9	[ACUTE PULMONARY HEART DISEASE DUE TO AMNIOTIC EMBOLISM. EXPERIMENTAL STUDY]. ³⁸	MOINE C...MARION P	14289703	1965
10	[ACUTE PULMONARY HEART DISEASE. II. PULMONARY EMBOLISM]. ³⁸	ERNST S	14251093	1964
11	[Various aspects of acute pulmonary heart disease caused by thromboembolism; doctrinal concept and antecedents]. ³⁸	SORRIBES-SANTAMARIA V	13358395	1956
12	[Pulmonary embolism and acute pulmonary heart disease; study of the syndrome and analysis of an observation]. ³⁸	BEAUCHESNE A	13308177	1955
13	[Acute pulmonary heart disease]. ³⁸	FAIVRE G	14359694	1955
14	[Surgical indications in acute pulmonary heart disease caused by pulmonary embolism]. ³⁸	TOURNIAIRE A...DEYRIEUX F	13195717	1954
15	[Study on a cardiac output in acute pulmonary heart disease]. ³⁸	FAIVRE G...HUEBER J	13178378	1954
16	[Acute pulmonary heart disease in serious asthma; therapy and cure]. ³⁸	DUSSERT A	13226252	1954

Sources

Genes for Acute Pulmonary Heart Disease

Genes related to Acute Pulmonary Heart Disease (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	POR	Cytochrome P450 Oxidoreductase	Protein Coding	15.15	DISEASES inferred ¹⁵
2	NPPB	Natriuretic Peptide B	Protein Coding	15.01	DISEASES inferred ¹⁵
3	PLG	Plasminogen	Protein Coding	14.99	DISEASES inferred ¹⁵
4	SLC22A12	Solute Carrier Family 22 Member 12	Protein Coding	14.66	DISEASES inferred ¹⁵
5	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	14.63	DISEASES inferred ¹⁵
6	CAST	Calpastatin	Protein Coding	14.61	DISEASES inferred ¹⁵
7	VCL	Vinculin	Protein Coding	14.55	DISEASES inferred ¹⁵
8	SERPINF2	Serpin Family F Member 2	Protein Coding	14.21	DISEASES inferred ¹⁵
9	SERPINE1	Serpin Family E Member 1	Protein Coding	13.2	DISEASES inferred ¹⁵
10	PIWIL2	Piwi Like RNA-Mediated Gene Silencing 2	Protein Coding	5.37	DISEASES inferred ¹⁵
11	PDZK1IP1	PDZK1 Interacting Protein 1	Protein Coding	5.28	DISEASES inferred ¹⁵

Sources

Variations for Acute Pulmonary Heart Disease

Sources

Expression for Acute Pulmonary Heart Disease

Search GEO for disease gene expression data for Acute Pulmonary Heart Disease.

Sources

Pathways for Acute Pulmonary Heart Disease

Pathways related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.88	VCL SERPINF2 SERPINE1 PLG PLAT
2	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.94	SERPINE1 PLG PLAT
3	Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶	11.66	SERPINF2 SERPINE1 PLG PLAT
4	Adhesion ⁴	11.59	VCL SERPINE1 PLG
5	Complement and coagulation cascades ³⁷ ¹	11.4	SERPINF2 SERPINE1 PLG PLAT
6	Cell adhesion_ECM remodeling ²²	11.22	SERPINE1 PLG PLAT
7	Cell adhesion_Plasmin signaling ²²	11.17	PLG PLAT
8	amb2 Integrin signaling ¹	11.14	PLG PLAT
9	A-beta Pathways: Plaque Formation and APP Metabolism ⁶⁵	10.73	PLG PLAT
10	Dissolution of Fibrin Clot ⁶⁶	10.04	SERPINF2 SERPINE1 PLG PLAT

Sources

GO Terms for Acute Pulmonary Heart Disease

Cellular components related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.73	VCL SERPINF2 SERPINE1 PLG PLAT NPPB
2	extracellular exosome	GO:0070062	9.7	VCL SLC22A12 SERPINF2 SERPINE1 PLG PLAT
3	collagen-containing extracellular matrix	GO:0062023	9.26	SERPINF2 SERPINE1 PLG PLAT
4	platelet alpha granule lumen	GO:0031093	8.8	SERPINF2 SERPINE1 PLG

Biological processes related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of peptidase activity	GO:0010466	9.5	SERPINF2 SERPINE1 CAST
2	platelet degranulation	GO:0002576	9.46	VCL SERPINF2 SERPINE1 PLG
3	negative regulation of plasminogen activation	GO:0010757	9.26	SERPINF2 SERPINE1
4	negative regulation of fibrinolysis	GO:0051918	9.13	SERPINF2 SERPINE1 PLG
5	fibrinolysis	GO:0042730	8.92	SERPINF2 SERPINE1 PLG PLAT

Molecular functions related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.46	SERPINE1 PLG PLAT NPPB
2	endopeptidase inhibitor activity	GO:0004866	9.26	SERPINF2 CAST
3	peptidase inhibitor activity	GO:0030414	9.13	SERPINF2 SERPINE1 CAST
4	protease binding	GO:0002020	8.8	SERPINF2 SERPINE1 CAST

Sources

Sources for Acute Pulmonary Heart Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia