MCID: ACT080
MIFTS: 28

Acute Pulmonary Heart Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Acute Pulmonary Heart Disease

MalaCards integrated aliases for Acute Pulmonary Heart Disease:

Name: Acute Pulmonary Heart Disease 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8514
ICD9CM 35 415
UMLS 73 C0155671

Summaries for Acute Pulmonary Heart Disease

MalaCards based summary : Acute Pulmonary Heart Disease is related to ligneous conjunctivitis and cardiogenic shock. An important gene associated with Acute Pulmonary Heart Disease is EDEM1 (ER Degradation Enhancing Alpha-Mannosidase Like Protein 1), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Adhesion. The drugs Warfarin and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, and related phenotypes are digestive/alimentary and respiratory system

Related Diseases for Acute Pulmonary Heart Disease

Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Acute Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 ligneous conjunctivitis 10.8 PLAT PLG
2 cardiogenic shock 10.7 NPPB PLAT
3 intestinal impaction 10.7 PLG SERPINF2
4 central retinal artery occlusion 10.7 PLAT PLG
5 alpha-2-plasmin inhibitor deficiency 10.7 PLG SERPINF2
6 giant hemangioma 10.7 PLG SERPINF2
7 platelet aggregation, spontaneous 10.6 PLAT SERPINF2
8 acute poststreptococcal glomerulonephritis 10.6 PLG SERPINF2
9 occlusion precerebral artery 10.6 PLAT PLG
10 basilar artery occlusion 10.5 PLAT PLG
11 fibrinolytic defect 10.5 PLAT SERPINE1
12 marantic endocarditis 10.5 PLAT SERPINF2
13 korean hemorrhagic fever 10.5 PLG SERPINF2
14 tuberculous empyema 10.5 PLG SERPINE1
15 argentine hemorrhagic fever 10.5 PLAT SERPINE1
16 inferior myocardial infarction 10.5 NPPB PLAT PLG
17 central serous chorioretinopathy 10.5 PLAT SERPINE1
18 blue toe syndrome 10.5 PLG SERPINE1
19 dysbaric osteonecrosis 10.5 PLG SERPINE1
20 intracranial embolism 10.4 PLAT PLG SERPINF2
21 carotid artery thrombosis 10.4 PLAT SERPINE1
22 angina pectoris 10.3 SERPINE1 SERPINF2
23 pulmonary embolism and infarction 10.3 ADAM17 WDFY2
24 vein disease 10.3 ADAM17 PLAT PLG
25 lemierre's syndrome 10.3 PLG SERPINE1
26 hepatic veno-occlusive disease 10.3 PLAT PLG SERPINE1
27 plasminogen activator inhibitor-1 deficiency 10.2 PLAT SERPINE1 SERPINF2
28 intermediate coronary syndrome 10.2 PLAT PLG
29 thrombophlebitis 10.2 PLAT SERPINE1 SERPINF2
30 disseminated intravascular coagulation 10.2 PLAT SERPINE1 SERPINF2
31 factor xiii deficiency 10.2 SERPINE1 SERPINF2
32 coronary thrombosis 10.1 PLAT SERPINE1
33 hepatic vascular disease 10.1 ADAM17 PLG SERPINE1
34 tricuspid valve disease 10.1 NPPB PDZK1IP1
35 quebec platelet disorder 10.0 SERPINE1 VCL
36 arteries, anomalies of 10.0 NPPB PLAT PLG SERPINE1
37 coronary artery anomaly 9.9 NPPB PLAT PLG SERPINE1
38 thrombophilia due to activated protein c resistance 9.9 PLAT PLG SERPINE1 SERPINF2
39 pulmonary hypertension 9.9 NPPB PLAT PLG SERPINE1
40 pulmonary embolism 9.9 NPPB PLAT SERPINE1 SERPINF2
41 thrombophilia 9.9 PLAT PLG SERPINE1 SERPINF2
42 stroke, ischemic 9.9 PLAT PLG SERPINE1 SERPINF2
43 chronic venous insufficiency 9.7 PLAT SERPINE1
44 acute myocardial infarction 9.6 NPPB PLAT PLG SERPINE1 SERPINF2
45 myocardial infarction 9.5 NPPB PLAT PLG SERPINE1 SERPINF2
46 acute cor pulmonale 5.2 CA2 CAMP CREB3L2 DESI2 EDEM1 NPPB

Graphical network of the top 20 diseases related to Acute Pulmonary Heart Disease:



Diseases related to Acute Pulmonary Heart Disease

Symptoms & Phenotypes for Acute Pulmonary Heart Disease

MGI Mouse Phenotypes related to Acute Pulmonary Heart Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 ADAM17 CA2 CREB3L2 PLAT PLG VCL
2 respiratory system MP:0005388 9.1 CA2 PLAT PLG POR SERPINE1 ADAM17

Drugs & Therapeutics for Acute Pulmonary Heart Disease

Drugs for Acute Pulmonary Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved 81-81-2 6691 54678486
2
Dopamine Approved 51-61-6, 62-31-7 681
3
Cabergoline Approved 81409-90-7 54746
4
Levodopa Approved 59-92-7 6047
5
Serine Approved, Nutraceutical 56-45-1 5951
6 Dabigatran
7 Dopamine agonists
8
protease inhibitors
9 Serine Proteinase Inhibitors
10 Neurotransmitter Agents
11 HIV Protease Inhibitors
12 Dopamine Agents
13 Peripheral Nervous System Agents
14 Anticoagulants
15 Protective Agents
16 Antithrombin III
17 Autonomic Agents
18 Antithrombins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
2 The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage Completed NCT02061748 Observational

Search NIH Clinical Center for Acute Pulmonary Heart Disease

Genetic Tests for Acute Pulmonary Heart Disease

Anatomical Context for Acute Pulmonary Heart Disease

MalaCards organs/tissues related to Acute Pulmonary Heart Disease:

41
Heart

Publications for Acute Pulmonary Heart Disease

Variations for Acute Pulmonary Heart Disease

Expression for Acute Pulmonary Heart Disease

Search GEO for disease gene expression data for Acute Pulmonary Heart Disease.

Pathways for Acute Pulmonary Heart Disease

GO Terms for Acute Pulmonary Heart Disease

Cellular components related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 CA2 CAMP PDZK1IP1 PLAT PLG SERPINE1
2 extracellular space GO:0005615 9.5 CA2 CAMP NPPB PLAT PLG SERPINE1
3 platelet alpha granule lumen GO:0031093 8.8 PLG SERPINE1 SERPINF2

Biological processes related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.46 PLG SERPINE1 SERPINF2 VCL
2 morphogenesis of an epithelium GO:0002009 9.32 CA2 VCL
3 negative regulation of plasminogen activation GO:0010757 9.26 SERPINE1 SERPINF2
4 negative regulation of fibrinolysis GO:0051918 9.13 PLG SERPINE1 SERPINF2
5 fibrinolysis GO:0042730 8.92 PLAT PLG SERPINE1 SERPINF2

Molecular functions related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.26 NPPB PLAT PLG SERPINE1
2 hydrolase activity GO:0016787 9.17 ADAM17 DESI2 EDEM1 PIWIL2 PLAT PLG

Sources for Acute Pulmonary Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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