MCID: ACT042
MIFTS: 47

Acute Pyelonephritis

Categories: Nephrological diseases

Aliases & Classifications for Acute Pyelonephritis

MalaCards integrated aliases for Acute Pyelonephritis:

Name: Acute Pyelonephritis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:559
ICD10 33 N10
ICD9CM 35 590.1
NCIt 50 C123215
SNOMED-CT 68 22352007 36689008
UMLS 73 C0520575

Summaries for Acute Pyelonephritis

MalaCards based summary : Acute Pyelonephritis is related to acute cystitis and bacteriuria. An important gene associated with Acute Pyelonephritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Ceftriaxone and Cefixime have been mentioned in the context of this disorder. Affiliated tissues include kidney, neutrophil and prostate, and related phenotypes are cardiovascular system and immune system

Related Diseases for Acute Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Acute Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
# Related Disease Score Top Affiliating Genes
1 acute cystitis 30.5 ALB CRP CXCL8 IL6
2 bacteriuria 30.5 CXCL8 CXCR1 IL6
3 cystitis 30.5 CRP CXCL8 IL6
4 pyelonephritis 30.3 ALB CRP CXCL8 CXCR1 CXCR2 IL10
5 septic arthritis 30.0 CRP CXCL8
6 acute kidney tubular necrosis 29.9 ALB NAGLU
7 adult respiratory distress syndrome 29.9 CXCL8 IL10 IL6
8 osteomyelitis 29.9 CXCL8 IL10 IL6
9 cholangitis 29.7 ALB CRP IL6
10 iga glomerulonephritis 29.7 ALB IL6 NAGLU
11 prostatitis 29.7 CXCL8 IL10 IL6
12 chronic kidney failure 29.7 ALB CRP IL6
13 pyelitis 29.7 CRP CXCL8 CXCR1 IL6
14 kidney disease 29.6 ADM ALB CRP IL6 NAGLU
15 brucellosis 29.6 CRP CXCL8 IL10 IL6
16 kawasaki disease 29.5 ALB CRP IL10 IL6
17 rheumatoid arthritis 29.4 CRP CXCL8 IL10 IL6
18 mesenteric lymphadenitis 10.3 CRP IL6
19 intermittent explosive disorder 10.3 CRP IL6
20 intermediate coronary syndrome 10.3 CRP IL6
21 pharyngitis 10.3 CRP CXCL8
22 radiculopathy 10.3 CXCL8 IL6
23 cowpox 10.3 CXCL8 IL6
24 cold agglutinin disease 10.3 CRP IL6
25 cryopyrin-associated periodic syndrome 10.2 CRP IL6
26 acute cholangitis 10.2 CRP IL6
27 myasthenic syndrome, congenital, 1a, slow-channel 10.2 CRP CXCL8
28 peptic ulcer perforation 10.2 ALB CRP
29 uremic pruritus 10.2 CRP IL6
30 recurrent corneal erosion 10.2 CXCL8 IL6
31 macular holes 10.2 ADM CXCL8
32 transient arthritis 10.2 ALB IL6
33 bagassosis 10.2 CXCL8 IL6
34 neutrophilia, hereditary 10.2 CRP IL6
35 streptococcal toxic-shock syndrome 10.2 CXCL8 IL6
36 spinal disease 10.2 CRP IL6
37 vesicoureteral reflux 1 10.2
38 vaginitis 10.2 CXCL8 IL6
39 papillary conjunctivitis 10.2 CXCL8 IL6
40 viral pneumonia 10.2 CRP IL6
41 cardiac rupture 10.2 CRP CXCL8
42 post-transplant lymphoproliferative disease 10.2 IL10 IL6
43 traumatic brain injury 10.2 IL10 IL6
44 hand, foot and mouth disease 10.2 IL10 IL6
45 noma 10.2 ALB CXCL8
46 intermediate uveitis 10.2 IL10 IL6
47 eales disease 10.2 IL10 IL6
48 cervix small cell carcinoma 10.2 CXCR1 CXCR2
49 acute monoblastic leukemia 10.2 CXCL8 IL6
50 gastrointestinal tuberculosis 10.2 ALB CRP

Graphical network of the top 20 diseases related to Acute Pyelonephritis:



Diseases related to Acute Pyelonephritis

Symptoms & Phenotypes for Acute Pyelonephritis

MGI Mouse Phenotypes related to Acute Pyelonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 ADM CRP CXCL10 CXCR2 IL10 IL6
2 immune system MP:0005387 9.81 ADM CRP CXCL10 CXCR1 CXCR2 IL10
3 liver/biliary system MP:0005370 9.43 ADM ALB CXCR2 IL10 IL6 NAGLU
4 neoplasm MP:0002006 9.02 ALB CXCR2 IL10 IL6 PGF

Drugs & Therapeutics for Acute Pyelonephritis

Drugs for Acute Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4,Phase 3 73384-59-5 5479530 5361919
2
Cefixime Approved, Investigational Phase 4 79350-37-1 5362065 54362
3
leucovorin Approved Phase 4,Phase 3 58-05-9 6006 143
4
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
5
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
6
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
7
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
8
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
9
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
14 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
15 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2
16 Fluoroquinolones Phase 4,Phase 2
17 Antitubercular Agents Phase 4,Phase 3,Not Applicable
18 Vitamin B9 Phase 4,Phase 3
19 Antiparasitic Agents Phase 4,Phase 3
20 Anti-Infective Agents, Urinary Phase 4,Phase 3,Phase 2
21 Folic Acid Antagonists Phase 4,Phase 3
22 Vitamin B Complex Phase 4,Phase 3
23 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
24 Renal Agents Phase 4,Phase 3,Phase 2
25 Antimalarials Phase 4,Phase 3
26 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
27 Antiprotozoal Agents Phase 4,Phase 3
28 Folate Phase 4,Phase 3
29 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2
30 Lactams Phase 4
31 Avibactam Approved Phase 3,Phase 2 1192500-31-4
32
Ceftazidime Approved Phase 3 78439-06-2, 72558-82-8 5481173
33
Meropenem Approved, Investigational Phase 3 119478-56-7 64778 441130
34
Tazobactam Approved Phase 3,Phase 2 89786-04-9 123630
35
Piperacillin Approved Phase 3,Phase 2 66258-76-2 43672
36
Edetic Acid Approved, Vet_approved Phase 3 62-33-9, 60-00-4 6049
37
Iron Approved Phase 3 7439-89-6 23925
38
Sulbactam Approved Phase 3,Phase 2 68373-14-8
39
Pentetic acid Approved Phase 3 67-43-6
40
Fosfomycin Approved Phase 2, Phase 3 23155-02-4 446987
41
Tigecycline Approved Phase 3 220620-09-7 5282044
42
Colistin Approved Phase 3 1264-72-8, 1066-17-7 5311054
43
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
44
Cefepime Approved, Investigational Phase 3,Phase 2 88040-23-7 5479537
45
Ceftibuten Approved, Investigational Phase 3 97519-39-6 5282241 5282242
46 carnitine Phase 3
47 Omega 3 Fatty Acid Phase 3
48 beta-Lactamase Inhibitors Phase 3,Phase 2
49 Avibactam, ceftazidime drug combination Phase 3
50 Thienamycins Phase 3

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old Completed NCT00136656 Phase 4 antibiotic;antibiotics
2 A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux Completed NCT00382343 Phase 4 Sulfamethoxazole/trimethoprim
3 Treatment's Duration of Acute Uncomplicated Pyelonephritis Completed NCT00873626 Phase 4 levofloxacin, ciprofloxacin and ofloxacin (fluoroquinolones)
4 Febrile Urinary Tract Infection Randomized Short Treatment Trial Completed NCT00809913 Phase 4 short treatment (ciprofloxacin)
5 Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women Completed NCT01390623 Phase 4 Ceftriaxone
6 Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis Recruiting NCT03179384 Phase 4 Ceftriaxone
7 L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis Unknown status NCT02007889 Phase 3 L-carnitine
8 Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in Children Unknown status NCT02192580 Phase 3 Omega-3
9 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01599806 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
10 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01595438 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
11 A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) Completed NCT02486627 Phase 3 plazomicin;meropenem;levofloxacin (oral)
12 A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. Completed NCT00210886 Phase 3 levofloxacin
13 Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP Completed NCT02166476 Phase 3 Meropenem-Vaborbactam;Piperacillin-Tazobactam;Levofloxacin;Saline
14 CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) Compared to Meropenem in Complicated Urinary Tract Infections (cUTIs) Caused by ESBL Producing Gram Negative Bacteria Completed NCT03477422 Phase 3 CSE-1034 (Ceftriaxone + Sulbactam + EDTA);Meropenem
15 Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections Completed NCT02753946 Phase 2, Phase 3 ZTI-01;Piperacillin-tazobactam
16 A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE) Completed NCT01970371 Phase 3 plazomicin;colistin;meropenem;tigecycline;antibiotic of Investigator's choice
17 Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults Completed NCT02168946 Phase 3 Vabomere;Best Available Therapy
18 Safety and Efficacy Study of Cefepime-AAI101 in the Treatment of Complicated Urinary Tract Infections Recruiting NCT03687255 Phase 3 cefepime/AAI101 combination;Piperacillin/tazobactam
19 Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Patients With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) Not yet recruiting NCT03788967 Phase 3 Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr);Ertapenem
20 Study of Cefepime-tazobactam (FEP-TAZ) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) Not yet recruiting NCT03630081 Phase 3 FEP-TAZ 4 g;Meropenem;ciprofloxacin 500 mg Optional Oral Switch
21 Short-term Antibiotic Therapy for Pyelonephritis in Childhood Terminated NCT00724256 Phase 3 ceftibuten;ceftibuten
22 Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli Unknown status NCT02537847 Phase 2 Sitafloxacin;Ertapenem
23 A Study of Plazomicin Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection (cUTI) and Acute Pyelonephritis (AP) Completed NCT01096849 Phase 2 levofloxacin;plazomicin;placebo
24 Effect of Acetylcysteine in Pediatric Acute Pyelonephritis. Completed NCT02080182 Phase 2 Acetylcysteine;placebo acetylcysteine
25 Finafloxacin for the Treatment of cUTI and/or Acute Pyelonephritis Completed NCT01928433 Phase 2 Finafloxacin 800 mg i.v. once daily;Finafloxacin placebo i.v. once daily;Finafloxacin 800 mg tablets once daily;Finafloxacin placebo tablets once daily;Ciprofloxacin 400 mg i.v. twice daily;Ciprofloxacin placebo i.v. twice daily;Ciprofloxacin 500 mg oral twice daily;Ciprofloxacin placebo oral twice daily
26 Evaluation of Safety and Efficacy of Intravenous Sulbactam-ETX2514 in the Treatment of Hospitalized Adults With Complicated Urinary Tract Infections Completed NCT03445195 Phase 2 Sulbactam-ETX2514;Placebo;Imipenem-cilastatin
27 Cefepime/AAI101 Phase 2 Study in Hospitalized Adults With cUTI Completed NCT03680612 Phase 2 Cefepime 1G - 2G / AAI101 0.5G - 0.75G;cefepime 1 g or cefepime 2 g
28 Comparative Study of Coadministered Ceftaroline Fosamil and NXL104 vs. Intravenous Doripenem in Adult Subjects With Complicated Urinary Tract Infections Completed NCT01281462 Phase 2 Ceftaroline fosamil and NXL104 (q8h);Ceftaroline fosamil and NXL104 (q12h);Doripenem;Placebo
29 IV or IV/PO Omadacycline vs. IV/PO Levofloxacin for the Treatment of Acute Pyelonephritis Recruiting NCT03757234 Phase 2 Omadacycline;Levofloxacin
30 Prospective Study in the Emergency Terminated NCT01628900 Phase 2
31 GSK2251052 in Complicated Urinary Tract Infection Terminated NCT01381549 Phase 2 GSK2251052;imipenem-cilastatin
32 Proteinuria During Acute Pyelonephritis In Pregnancy Unknown status NCT02536638
33 Dexamethasone Administration in 1st Episode of Febrile Urinary Tract Infection Unknown status NCT02034851
34 Contrast-Enhanced US of Spleen, Liver and Kidney Unknown status NCT00190281
35 Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis Unknown status NCT00868270
36 Community-Associated Uropathogen Antimicrobial Resistance Among Emergency Department Patients With Acute Pyelonephritis Completed NCT01641029
37 Kinetics of Biomarkers in Acute Pyelonephritis Completed NCT00805181
38 Prospective Comparative Study About Treatment of Asymptomatic Bacteriuria in Kidney Transplant Recipients. Completed NCT02373085 Not Applicable
39 Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae Completed NCT02420366
40 Postlicensure Observational Safety Study of 13vPnC Administered to Infants and Toddlers Completed NCT01128426
41 Incidence of Post Cystography Urinary Tract Infections in the Pediatric Population Recruiting NCT03399682
42 Efficacy and Pharmacokinetic/Pharmacodynamic Parameters of Cefoxitin in Women With Acute Pyelonephritis Without Severity Symptoms Due to Extended-spectrum β-lactamase Producing Escherichia Coli Terminated NCT01820793 Not Applicable Cefoxitin
43 Bacterial and Host Genetic Risk Factors in Acute Pyelonephritis Withdrawn NCT01137929

Search NIH Clinical Center for Acute Pyelonephritis

Genetic Tests for Acute Pyelonephritis

Anatomical Context for Acute Pyelonephritis

MalaCards organs/tissues related to Acute Pyelonephritis:

41
Kidney, Neutrophil, Prostate, Thyroid, Brain, Heart, Eye

Publications for Acute Pyelonephritis

Articles related to Acute Pyelonephritis:

(show top 50) (show all 701)
# Title Authors Year
1
Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis: A Multicenter, Randomized, Double-Blind, Phase 2 Study. ( 29378708 )
2018
2
Risk Factors for Uroseptic Shock in Patients with Urolithiasis-Related Acute Pyelonephritis. ( 29065405 )
2018
3
Diffusion tensor imaging in acute pyelonephritis in children. ( 29789888 )
2018
4
Acute Pyelonephritis in Adults. ( 29565517 )
2018
5
Outcome of children with ESBL-E. coli acute pyelonephritis treated with cephalosporins. ( 29746942 )
2018
6
Reply: Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637754 )
2018
7
Acute Pyelonephritis in Adults. ( 29298155 )
2018
8
D-dimer as a marker of acute pyelonephritis in infants younger than 24A months with urinary tract infection. ( 29306986 )
2018
9
Phylogenetic relationships, biofilm formation, motility, antibiotic resistance and extended virulence genotypes among Escherichia coli strains from women with community-onset primitive acute pyelonephritis. ( 29758033 )
2018
10
Re. "Diffusion weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: AA prospective study". ( 29778699 )
2018
11
Diffusion-weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: AA prospective study. ( 29588142 )
2018
12
Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637753 )
2018
13
Acute Pyelonephritis in Adults. ( 29562155 )
2018
14
Stopping the effective non-fluoroquinolone antibiotics at day 7 vs continuing until day 14 in adults with acute pyelonephritis requiring hospitalization: A randomized non-inferiority trial. ( 29768465 )
2018
15
Acute Pyelonephritis in Adults. ( 29539281 )
2018
16
The use of cefepime as a carbapenem-sparing antibiotic for treating uncomplicated acute pyelonephritis caused by extended-spectrum I^-lactamase producing Escherichia coli. ( 29086602 )
2018
17
Renal vein thrombosis complicating severe acute pyelonephritis with renal abscesses and associated bacteraemia caused by extended-spectrum beta-lactamase producing Escherichia coli. ( 29327131 )
2018
18
Mecillinam for the treatment of acute pyelonephritis and bacteremia caused by Enterobacteriaceae: a literature review. ( 29872326 )
2018
19
Mild encephalopathy with a reversible splenial lesion in a girl with acute pyelonephritis. ( 29563947 )
2018
20
Non-enhanced magnetic resonance imaging versus renal scintigraphy in acute pyelonephritis. ( 29473304 )
2018
21
Erratum: Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis [Corrigendum]. ( 29497327 )
2018
22
Efficacy and Cost Comparison of Ertapenem as Outpatient Parenteral Antimicrobial Therapy in Acute Pyelonephritis due to Extended-spectrum Beta-lactamase-producing Enterobacteriaceae. ( 30270995 )
2018
23
Host and microbial factors in kidney transplant recipients with Escherichia coli acute pyelonephritis or asymptomatic bacteriuria: a prospective study using whole-genome sequencing. ( 30304506 )
2018
24
Management of acute pyelonephritis. ( 30324991 )
2018
25
ACR Appropriateness Criteria® Acute Pyelonephritis. ( 30392592 )
2018
26
Preventive Effect of L-Carnitine on Scar Formation During Acute Pyelonephritis: A Randomized Placebo-Controlled Trial. ( 30418227 )
2018
27
Giant hydronephrosis presenting as acute pyelonephritis. ( 30418837 )
2018
28
Mild encephalopathy/encephalitis with a reversible splenial lesion associated with acute pyelonephritis: A case report. ( 30446174 )
2018
29
Adrenal crisis presented as acute onset of hypercalcemia and hyponatremia triggered by acute pyelonephritis in a patient with partial hypopituitarism and pre-dialysis chronic kidney disease. ( 30456557 )
2018
30
Isolation of a Capnophilic and an Extended-Spectrum-β-Lactamase-Producing Proteus mirabilis Isolate with Inability to Grow under pH-Indicator Dyes from the Urine of an Octogenarian Male-Patient with Acute Pyelonephritis. ( 30504644 )
2018
31
Descriptive Epidemiology of Acute Pyelonephritis in Korea, 2010-2014: Population-based Study. ( 30505253 )
2018
32
Has the Incidence of Acute Pyelonephritis Increased in Korea? - Big Data as a Double-edged Sword. ( 30505256 )
2018
33
Follow-up of acute pyelonephritis: what causes the diffusion-weighted magnetic resonance imaging recovery to lag clinical recovery? ( 28660334 )
2018
34
Therapeutic effects of 5,2'-dibromo-2,4',5'-trihydroxydiphenylmethanone (LM49) in an experimental rat model of acute pyelonephritis by immunomodulation and anti-inflammation. ( 30007245 )
2018
35
Atypical Presentation of IgA Nephropathy Mimicking Acute Pyelonephritis. ( 30008750 )
2018
36
Studies on biofilm formation and virulence factors associated with uropathogenic Escherichia coli isolated from patient with acute pyelonephritis. ( 30032909 )
2018
37
Re: Acute Pyelonephritis in Adults. ( 30037528 )
2018
38
Acute pyelonephritis revealing an intraprostatic obstructive megaureter in an adult: A rare finding. ( 30144716 )
2018
39
Meropenem-vaborbactam for the treatment of complicated urinary tract infections including acute pyelonephritis. ( 30160990 )
2018
40
Comparison between non-septic and septic cases in stone-related obstructive acute pyelonephritis and risk factors for septic shock: A multi-center retrospective study. ( 30174285 )
2018
41
Blood culture for complicated acute pyelonephritis with ureteral stone: are they unnecessary? ( 30182772 )
2018
42
A systematic review of randomised clinical trials for oral antibiotic treatment of acute pyelonephritis. ( 30191339 )
2018
43
Glomerular filtration rate determination by creatinine and cystatin-C in patients with acute pyelonephritis. ( 30197775 )
2018
44
Antinatriuretic phenomena seen in children with acute pyelonephritis may be related to the activation of intrarenal RAAS. ( 30200111 )
2018
45
Clinical Usefulness of Unenhanced Computed Tomography in Patients with Acute Pyelonephritis. ( 30224907 )
2018
46
C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli. ( 29263309 )
2017
47
Neuroinvasive Infection from O117:K52:H-<i>Escherichia coli</i>following Acute Pyelonephritis. ( 29318066 )
2017
48
Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis. ( 28507449 )
2017
49
Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients. ( 27889429 )
2017
50
A randomized controlled trial of sitafloxacin vs. ertapenem as a switchA therapy after treatment for acute pyelonephritis caused by extended-spectrum I^-lactamase-producing Escherichia coli: A pilot study. ( 28587974 )
2017

Variations for Acute Pyelonephritis

Expression for Acute Pyelonephritis

Search GEO for disease gene expression data for Acute Pyelonephritis.

Pathways for Acute Pyelonephritis

Pathways related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
2
Show member pathways
13.01 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
3
Show member pathways
12.77 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
4
Show member pathways
12.66 CXCL10 CXCL8 CXCR1 CXCR2
5
Show member pathways
12.03 CXCL8 IL10 IL6 PGF
6
Show member pathways
12 CXCL10 CXCL8 CXCR1 CXCR2
7
Show member pathways
11.97 CXCL10 CXCL8 IL6
8 11.96 CXCL8 IL10 IL6
9
Show member pathways
11.85 CXCL8 IL10 IL6 PGF
10 11.81 CXCL10 CXCL8 IL6
11 11.78 CXCL8 IL10 IL6
12 11.67 CXCL8 IL10 IL6
13
Show member pathways
11.62 CXCL10 CXCL8 CXCR1 CXCR2
14 11.55 CXCL8 IL10 IL6
15 11.5 CXCL10 IL10 IL6
16 11.32 CXCL8 CXCR1 IL6
17 11.27 CXCL8 IL10 IL6
18 11.06 IL10 IL6
19 10.9 CXCL10 CXCL8 IL10 IL6
20 10.76 CXCL10 CXCL8 IL10 IL6 PGF
21 10.61 CXCL10 CXCL8 IL10 IL6
22 10.41 CRP CXCL8 IL6

GO Terms for Acute Pyelonephritis

Cellular components related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ADM ALB CRP CXCL10 CXCL8 IL10
2 extracellular space GO:0005615 9.23 ADM ALB CRP CXCL10 CXCL8 IL10

Biological processes related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 ALB CXCR2 IL10 IL6
2 negative regulation of cell proliferation GO:0008285 9.92 ADM CXCL8 IL10 IL6
3 positive regulation of cell proliferation GO:0008284 9.91 ADM CXCL10 CXCR2 IL6 PGF
4 cytokine-mediated signaling pathway GO:0019221 9.84 CXCL10 CXCL8 IL10 IL6
5 response to lipopolysaccharide GO:0032496 9.8 ADM CXCL10 IL10
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 ADM CXCR1 CXCR2
7 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL10 CXCL8 IL10 IL6
8 immune response GO:0006955 9.8 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
9 chemotaxis GO:0006935 9.78 CXCL10 CXCL8 CXCR1 CXCR2
10 positive regulation of angiogenesis GO:0045766 9.76 ADM CXCL8 CXCR2 PGF
11 calcium-mediated signaling GO:0019722 9.73 CXCL8 CXCR1 CXCR2
12 cell chemotaxis GO:0060326 9.72 CXCL10 CXCR1 CXCR2
13 response to glucocorticoid GO:0051384 9.7 ADM IL10 IL6
14 neutrophil chemotaxis GO:0030593 9.67 CXCL10 CXCL8 CXCR1 CXCR2
15 positive regulation of neutrophil chemotaxis GO:0090023 9.63 CXCL8 CXCR2
16 regulation of signaling receptor activity GO:0010469 9.63 ADM CXCL10 CXCL8 IL10 IL6 PGF
17 dendritic cell chemotaxis GO:0002407 9.61 CXCR1 CXCR2
18 induction of positive chemotaxis GO:0050930 9.61 CXCL8 PGF
19 response to molecule of bacterial origin GO:0002237 9.6 CXCL8 IL10
20 neutrophil activation GO:0042119 9.59 CXCL8 CXCR2
21 positive regulation of leukocyte chemotaxis GO:0002690 9.58 CXCR2 IL6
22 branching involved in labyrinthine layer morphogenesis GO:0060670 9.58 ADM IL10
23 leukocyte chemotaxis GO:0030595 9.58 CXCL10 CXCL8 IL10
24 negative regulation of lipid storage GO:0010888 9.57 CRP IL6
25 chemokine-mediated signaling pathway GO:0070098 9.56 CXCL10 CXCL8 CXCR1 CXCR2
26 interleukin-8-mediated signaling pathway GO:0038112 9.43 CXCR1 CXCR2
27 inflammatory response GO:0006954 9.43 CRP CXCL10 CXCL8 CXCR2 IL10 IL6
28 receptor internalization GO:0031623 8.92 ADM CXCL8 CXCR1 CXCR2
29 signal transduction GO:0007165 10.11 ADM CXCL10 CXCL8 CXCR1 CXCR2 PGF
30 G protein-coupled receptor signaling pathway GO:0007186 10.04 ADM CXCL10 CXCL8 CXCR1 CXCR2

Molecular functions related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.58 IL10 IL6 PGF
2 chemokine binding GO:0019956 9.46 CXCR1 CXCR2
3 cytokine activity GO:0005125 9.46 CXCL10 CXCL8 IL10 IL6
4 C-C chemokine binding GO:0019957 9.43 CXCR1 CXCR2
5 C-C chemokine receptor activity GO:0016493 9.37 CXCR1 CXCR2
6 chemokine receptor activity GO:0004950 9.32 CXCR1 CXCR2
7 C-X-C chemokine receptor activity GO:0016494 9.26 CXCR1 CXCR2
8 interleukin-8 binding GO:0019959 8.96 CXCR1 CXCR2
9 interleukin-8 receptor activity GO:0004918 8.62 CXCR1 CXCR2

Sources for Acute Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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