MCID: ACT042
MIFTS: 47

Acute Pyelonephritis

Categories: Nephrological diseases

Aliases & Classifications for Acute Pyelonephritis

MalaCards integrated aliases for Acute Pyelonephritis:

Name: Acute Pyelonephritis 12 56 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:559
ICD9CM 36 590.1
NCIt 51 C123215
SNOMED-CT 69 22352007 36689008
ICD10 34 N10
UMLS 74 C0520575

Summaries for Acute Pyelonephritis

MalaCards based summary : Acute Pyelonephritis is related to cystitis and acute cystitis. An important gene associated with Acute Pyelonephritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Ceftriaxone and Cefixime have been mentioned in the context of this disorder. Affiliated tissues include kidney, neutrophil and prostate, and related phenotypes are cardiovascular system and immune system

Related Diseases for Acute Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Acute Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
# Related Disease Score Top Affiliating Genes
1 cystitis 30.6 CRP CXCL8 IL6
2 acute cystitis 30.5 ALB CRP CXCL8 IL6
3 bacteriuria 30.3 CXCL8 CXCR1 CXCR2 IL6
4 septic arthritis 30.3 CRP CXCL8
5 acute kidney tubular necrosis 30.0 ALB NAGLU
6 adult respiratory distress syndrome 30.0 CXCL8 IL10 IL6
7 osteomyelitis 30.0 CXCL8 IL10 IL6
8 cholangitis 29.8 ALB CRP IL6
9 prostatitis 29.8 CXCL8 IL10 IL6
10 pyelitis 29.7 CRP CXCL8 CXCR1 IL6
11 iga glomerulonephritis 29.7 ALB IL6 NAGLU
12 chronic kidney failure 29.7 ALB CRP IL6
13 brucellosis 29.5 CRP CXCL8 IL10 IL6
14 pyelonephritis 29.5 ALB CRP CXCL8 CXCR1 CXCR2 IL10
15 kawasaki disease 29.4 ALB CRP IL10 IL6
16 kidney disease 29.4 ADM ALB CRP IL6 NAGLU
17 rheumatoid arthritis 29.4 CRP CXCL8 IL10 IL6
18 pre-eclampsia 29.0 ADM IL10 IL6 PGF
19 mesenteric lymphadenitis 10.5 CRP IL6
20 intermittent explosive disorder 10.5 CRP IL6
21 intermediate coronary syndrome 10.4 CRP IL6
22 pharyngitis 10.4 CRP CXCL8
23 cowpox 10.4 CXCL8 IL6
24 cold agglutinin disease 10.4 CRP IL6
25 cryopyrin-associated periodic syndrome 10.4 CRP IL6
26 acute cholangitis 10.4 CRP IL6
27 myasthenic syndrome, congenital, 1a, slow-channel 10.4 CRP CXCL8
28 uremic pruritus 10.4 CRP IL6
29 recurrent corneal erosion 10.4 CXCL8 IL6
30 neutrophilia, hereditary 10.4 CRP IL6
31 macular holes 10.4 ADM CXCL8
32 bagassosis 10.3 CXCL8 IL6
33 streptococcal toxic-shock syndrome 10.3 CXCL8 IL6
34 spinal disease 10.3 CRP IL6
35 cervix small cell carcinoma 10.3 CXCR1 CXCR2
36 vaginitis 10.3 CXCL8 IL6
37 papillary conjunctivitis 10.3 CXCL8 IL6
38 viral pneumonia 10.3 CRP IL6
39 peptic ulcer perforation 10.3 ALB CRP
40 cardiac rupture 10.3 CRP CXCL8
41 post-transplant lymphoproliferative disease 10.3 IL10 IL6
42 traumatic brain injury 10.3 IL10 IL6
43 hand, foot and mouth disease 10.3 IL10 IL6
44 transient arthritis 10.3 ALB IL6
45 intermediate uveitis 10.3 IL10 IL6
46 eales disease 10.3 IL10 IL6
47 acute monoblastic leukemia 10.3 CXCL8 IL6
48 relapsing polychondritis 10.3 CRP IL6
49 central nervous system vasculitis 10.3 CRP IL6
50 subacute thyroiditis 10.3 CRP IL6

Graphical network of the top 20 diseases related to Acute Pyelonephritis:



Diseases related to Acute Pyelonephritis

Symptoms & Phenotypes for Acute Pyelonephritis

MGI Mouse Phenotypes related to Acute Pyelonephritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 ADM CRP CXCL10 CXCR2 IL10 IL6
2 immune system MP:0005387 9.81 ADM CRP CXCL10 CXCR1 CXCR2 IL10
3 liver/biliary system MP:0005370 9.43 ADM ALB CXCR2 IL10 IL6 NAGLU
4 neoplasm MP:0002006 9.02 ALB CXCR2 IL10 IL6 PGF

Drugs & Therapeutics for Acute Pyelonephritis

Drugs for Acute Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4,Phase 3 73384-59-5 5479530 5361919
2
Cefixime Approved, Investigational Phase 4 79350-37-1 5362065 54362
3
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
4
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
5
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
6
leucovorin Approved Phase 4,Phase 3 58-05-9 143 6006
7
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
8
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
9
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
11 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
14 Fluoroquinolones Phase 4,Phase 2
15 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2
16 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
17 Antitubercular Agents Phase 4,Phase 3,Not Applicable
18 Folate Phase 4,Phase 3
19 Anti-Infective Agents, Urinary Phase 4,Phase 3,Phase 2
20 Antimalarials Phase 4,Phase 3
21 Renal Agents Phase 4,Phase 3,Phase 2
22 Folic Acid Antagonists Phase 4,Phase 3
23 Antiparasitic Agents Phase 4,Phase 3
24 Antiprotozoal Agents Phase 4,Phase 3
25 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
26 Vitamin B9 Phase 4,Phase 3
27 Vitamin B Complex Phase 4,Phase 3
28 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
29 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2
30 Lactams Phase 4
31
Ertapenem Approved, Investigational Phase 3,Phase 2 153832-46-3 150610
32
Doripenem Approved, Investigational Phase 3,Phase 2 148016-81-3 73303
33
Ceftazidime Approved Phase 3 72558-82-8, 78439-06-2 5481173
34
Avibactam Approved Phase 3,Phase 2 1192500-31-4
35
Meropenem Approved, Investigational Phase 3 119478-56-7, 96036-03-2 441130 64778
36
Vaborbactam Approved, Investigational Phase 3 1360457-46-0
37
Tazobactam Approved Phase 3,Phase 2 89786-04-9 123630
38
Piperacillin Approved Phase 3,Phase 2 66258-76-2 43672
39
Sulbactam Approved Phase 3,Phase 2 68373-14-8
40
Edetic Acid Approved, Vet_approved Phase 3 60-00-4, 62-33-9 6049
41
Pentetic acid Approved Phase 3 67-43-6
42
Iron Approved, Experimental Phase 3 7439-89-6, 15438-31-0 27284 23925
43
Fosfomycin Approved Phase 2, Phase 3 23155-02-4 446987
44
Tigecycline Approved Phase 3 220620-09-7 5282044
45
Colistin Approved Phase 3 1066-17-7, 1264-72-8 5311054
46
Cefepime Approved, Investigational Phase 3,Phase 2 88040-23-7 5479537
47
Ceftibuten Approved, Investigational Phase 3 97519-39-6 5282242 5282241
48
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
49 carnitine Phase 3
50 Omega 3 Fatty Acid Phase 3

Interventional clinical trials:

(show all 45)
# Name Status NCT ID Phase Drugs
1 Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old Completed NCT00136656 Phase 4 antibiotic;antibiotics
2 A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux Completed NCT00382343 Phase 4 Sulfamethoxazole/trimethoprim
3 Treatment's Duration of Acute Uncomplicated Pyelonephritis Completed NCT00873626 Phase 4 levofloxacin, ciprofloxacin and ofloxacin (fluoroquinolones)
4 Febrile Urinary Tract Infection Randomized Short Treatment Trial Completed NCT00809913 Phase 4 short treatment (ciprofloxacin)
5 Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women Completed NCT01390623 Phase 4 Ceftriaxone
6 Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis Recruiting NCT03179384 Phase 4 Ceftriaxone
7 L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis Unknown status NCT02007889 Phase 3 L-carnitine
8 Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in Children Unknown status NCT02192580 Phase 3 Omega-3
9 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01599806 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
10 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01595438 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
11 A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) Completed NCT02486627 Phase 3 plazomicin;meropenem;levofloxacin (oral)
12 A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. Completed NCT00210886 Phase 3 levofloxacin
13 Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP Completed NCT02166476 Phase 3 Meropenem-Vaborbactam;Piperacillin-Tazobactam;Levofloxacin;Saline
14 CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) Compared to Meropenem in Complicated Urinary Tract Infections (cUTIs) Caused by ESBL Producing Gram Negative Bacteria Completed NCT03477422 Phase 3 CSE-1034 (Ceftriaxone + Sulbactam + EDTA);Meropenem
15 Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections Completed NCT02753946 Phase 2, Phase 3 ZTI-01;Piperacillin-tazobactam
16 A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE) Completed NCT01970371 Phase 3 plazomicin;colistin;meropenem;tigecycline;antibiotic of Investigator's choice
17 Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults Completed NCT02168946 Phase 3 Vabomere;Best Available Therapy
18 Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Patients With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) Recruiting NCT03788967 Phase 3 Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr);Ertapenem
19 Safety and Efficacy Study of Cefepime-AAI101 in the Treatment of Complicated Urinary Tract Infections Recruiting NCT03687255 Phase 3 cefepime/AAI101 combination;Piperacillin/tazobactam
20 Study of Cefepime-tazobactam (FEP-TAZ) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) Not yet recruiting NCT03630081 Phase 3 FEP-TAZ 4 g;Meropenem;ciprofloxacin 500 mg Optional Oral Switch
21 Safety and Efficacy Study of Cefepime/VNRX-5133 in Patients With Complicated Urinary Tract Infections Not yet recruiting NCT03840148 Phase 3 Cefepime/VNRX-5133;Meropenem
22 Short-term Antibiotic Therapy for Pyelonephritis in Childhood Terminated NCT00724256 Phase 3 ceftibuten;ceftibuten
23 Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli Unknown status NCT02537847 Phase 2 Sitafloxacin;Ertapenem
24 A Study of Plazomicin Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection (cUTI) and Acute Pyelonephritis (AP) Completed NCT01096849 Phase 2 levofloxacin;plazomicin;placebo
25 Effect of Acetylcysteine in Pediatric Acute Pyelonephritis. Completed NCT02080182 Phase 2 Acetylcysteine;placebo acetylcysteine
26 Finafloxacin for the Treatment of cUTI and/or Acute Pyelonephritis Completed NCT01928433 Phase 2 Finafloxacin 800 mg i.v. once daily;Finafloxacin placebo i.v. once daily;Finafloxacin 800 mg tablets once daily;Finafloxacin placebo tablets once daily;Ciprofloxacin 400 mg i.v. twice daily;Ciprofloxacin placebo i.v. twice daily;Ciprofloxacin 500 mg oral twice daily;Ciprofloxacin placebo oral twice daily
27 Evaluation of Safety and Efficacy of Intravenous Sulbactam-ETX2514 in the Treatment of Hospitalized Adults With Complicated Urinary Tract Infections Completed NCT03445195 Phase 2 Sulbactam-ETX2514;Placebo;Imipenem-cilastatin
28 Cefepime/AAI101 Phase 2 Study in Hospitalized Adults With cUTI Completed NCT03680612 Phase 2 Cefepime 1G - 2G / AAI101 0.5G - 0.75G;cefepime 1 g or cefepime 2 g
29 Comparative Study of Coadministered Ceftaroline Fosamil and NXL104 vs. Intravenous Doripenem in Adult Subjects With Complicated Urinary Tract Infections Completed NCT01281462 Phase 2 Ceftaroline fosamil and NXL104 (q8h);Ceftaroline fosamil and NXL104 (q12h);Doripenem;Placebo
30 IV or IV/PO Omadacycline vs. IV/PO Levofloxacin for the Treatment of Acute Pyelonephritis Recruiting NCT03757234 Phase 2 Omadacycline;Levofloxacin
31 Prospective Study in the Emergency Terminated NCT01628900 Phase 2
32 GSK2251052 in Complicated Urinary Tract Infection Terminated NCT01381549 Phase 2 GSK2251052;imipenem-cilastatin
33 Proteinuria During Acute Pyelonephritis In Pregnancy Unknown status NCT02536638
34 Dexamethasone Administration in 1st Episode of Febrile Urinary Tract Infection Unknown status NCT02034851
35 Contrast-Enhanced US of Spleen, Liver and Kidney Unknown status NCT00190281
36 Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis Unknown status NCT00868270
37 Community-Associated Uropathogen Antimicrobial Resistance Among Emergency Department Patients With Acute Pyelonephritis Completed NCT01641029
38 Kinetics of Biomarkers in Acute Pyelonephritis Completed NCT00805181
39 Prospective Comparative Study About Treatment of Asymptomatic Bacteriuria in Kidney Transplant Recipients. Completed NCT02373085 Not Applicable
40 Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae Completed NCT02420366
41 Postlicensure Observational Safety Study of 13vPnC Administered to Infants and Toddlers Completed NCT01128426
42 The Validity of the Quick Renal MRI in Pediatric Kidney Disease Recruiting NCT03959163 Not Applicable
43 Incidence of Post Cystography Urinary Tract Infections in the Pediatric Population Recruiting NCT03399682
44 Efficacy and Pharmacokinetic/Pharmacodynamic Parameters of Cefoxitin in Women With Acute Pyelonephritis Without Severity Symptoms Due to Extended-spectrum β-lactamase Producing Escherichia Coli Terminated NCT01820793 Not Applicable Cefoxitin
45 Bacterial and Host Genetic Risk Factors in Acute Pyelonephritis Withdrawn NCT01137929

Search NIH Clinical Center for Acute Pyelonephritis

Genetic Tests for Acute Pyelonephritis

Anatomical Context for Acute Pyelonephritis

MalaCards organs/tissues related to Acute Pyelonephritis:

42
Kidney, Neutrophil, Prostate, Liver, Thyroid, Lung, Spleen

Publications for Acute Pyelonephritis

Articles related to Acute Pyelonephritis:

(show top 50) (show all 719)
# Title Authors Year
1
Remarkable improvement in progressive multifocal leukoencephalopathy following acute pyelonephritis with bacteremia. ( 30612916 )
2019
2
Oral sitafloxacin vs intravenous ceftriaxone followed by oral cefdinir for acute pyelonephritis and complicated urinary tract infection: a randomized controlled trial. ( 30662274 )
2019
3
Vitamin A supplementation is effective for improving the clinical symptoms of urinary tract infections and reducing renal scarring in girls with acute pyelonephritis: a randomized, double-blind placebo-controlled, clinical trial study. ( 30670279 )
2019
4
Imaging in Acute Pyelonephritis: Utilization, Findings, and Effect on Management. ( 30708379 )
2019
5
The Use of Mobile Educational Tools to Improve Antimicrobial Prescription for the Treatment of Acute Pyelonephritis in Pregnancy: A Retrospective Cross-sectional Study. ( 30786306 )
2019
6
Urinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in children. ( 30796728 )
2019
7
Quick Sequential (Sepsis Related) Organ Failure Assessment: A high performance rapid prognostication tool in patients having acute pyelonephritis with upper urinary tract calculi. ( 30838345 )
2019
8
Serum alkaline phosphatase and γ-glutamyl transferase in acute pyelonephritis. ( 30841691 )
2019
9
Fosfomycin for injection (ZTI-01) vs Piperacillin-Tazobactam (PIP-TAZ) for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP): ZEUS, A Phase 2/3 Randomized Trial. ( 30861061 )
2019
10
Inappropriate empirical antibiotic therapy does not adversely affect the clinical outcomes of patients with acute pyelonephritis caused by extended-spectrum β-lactamase-producing Enterobacteriales. ( 30868326 )
2019
11
Incidence, risk factors, and clinical outcomes of acute kidney injury associated with acute pyelonephritis in patients attending a tertiary care referral center. ( 30942133 )
2019
12
Acute pyelonephritis and renal abscess due to ureteral stone. ( 31070143 )
2019
13
Perinephric Fat Stranding on Postmortem Computed Tomography Scan in Acute Pyelonephritis: A Case Report. ( 31094715 )
2019
14
Comparison of Tc-99m DMSA Renal Planar Scan and SPECT for Detection of Cortical Defects in Infants with Suspected Acute Pyelonephritis. ( 31098932 )
2019
15
Blood culture for complicated acute pyelonephritis with ureteral stone: are they unnecessary? ( 30182772 )
2019
16
Host and microbial factors in kidney transplant recipients with Escherichia coli acute pyelonephritis or asymptomatic bacteriuria: a prospective study using whole-genome sequencing. ( 30304506 )
2019
17
Adrenal crisis presented as acute onset of hypercalcemia and hyponatremia triggered by acute pyelonephritis in a patient with partial hypopituitarism and pre-dialysis chronic kidney disease. ( 30456557 )
2019
18
Factors associated with the recurrence of acute pyelonephritis caused by extended-spectrum β-lactamase-producing Escherichia coli: the importance of infectious disease consultation. ( 30642718 )
2018
19
Acute Pyelonephritis: A Single-center Experience. ( 30647500 )
2018
20
Follow-up of acute pyelonephritis: what causes the diffusion-weighted magnetic resonance imaging recovery to lag clinical recovery? ( 28660334 )
2018
21
Qualitative and quantitative radiological analysis of non-contrast CT is a strong indicator in patients with acute pyelonephritis. ( 29055617 )
2018
22
Risk Factors for Uroseptic Shock in Patients with Urolithiasis-Related Acute Pyelonephritis. ( 29065405 )
2018
23
The use of cefepime as a carbapenem-sparing antibiotic for treating uncomplicated acute pyelonephritis caused by extended-spectrum β-lactamase producing Escherichia coli. ( 29086602 )
2018
24
The role of nonautologous and autologous adipose-derived mesenchymal stem cell in acute pyelonephritis. ( 29218427 )
2018
25
Performance of Quick Sequential (Sepsis Related) and Sequential (Sepsis Related) Organ Failure Assessment to Predict Mortality in Patients with Acute Pyelonephritis Associated with Upper Urinary Tract Calculi. ( 29291417 )
2018
26
Acute Pyelonephritis in Adults. ( 29298155 )
2018
27
D-dimer as a marker of acute pyelonephritis in infants younger than 24 months with urinary tract infection. ( 29306986 )
2018
28
Renal vein thrombosis complicating severe acute pyelonephritis with renal abscesses and associated bacteraemia caused by extended-spectrum beta-lactamase producing Escherichia coli. ( 29327131 )
2018
29
A Multicenter, Randomized, Double-Blind, Phase 2 Study of the Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis. ( 29378708 )
2018
30
Ultrasonography of acute flank pain: a focus on renal stones and acute pyelonephritis. ( 29382187 )
2018
31
Non-enhanced magnetic resonance imaging versus renal scintigraphy in acute pyelonephritis. ( 29473304 )
2018
32
Erratum: Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis [Corrigendum]. ( 29497327 )
2018
33
Acute Pyelonephritis in Adults. ( 29539281 )
2018
34
Acute Pyelonephritis in Adults. ( 29562155 )
2018
35
Mild encephalopathy with a reversible splenial lesion in a girl with acute pyelonephritis. ( 29563947 )
2018
36
Acute Pyelonephritis in Adults. ( 29565517 )
2018
37
Diffusion-weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: A prospective study. ( 29588142 )
2018
38
Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637753 )
2018
39
Reply: Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637754 )
2018
40
Outcome of children with ESBL-E. coli acute pyelonephritis treated with cephalosporins. ( 29746942 )
2018
41
Phylogenetic relationships, biofilm formation, motility, antibiotic resistance and extended virulence genotypes among Escherichia coli strains from women with community-onset primitive acute pyelonephritis. ( 29758033 )
2018
42
Stopping the effective non-fluoroquinolone antibiotics at day 7 vs continuing until day 14 in adults with acute pyelonephritis requiring hospitalization: A randomized non-inferiority trial. ( 29768465 )
2018
43
Re. "Diffusion weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: A prospective study". ( 29778699 )
2018
44
Diffusion tensor imaging in acute pyelonephritis in children. ( 29789888 )
2018
45
Mecillinam for the treatment of acute pyelonephritis and bacteremia caused by Enterobacteriaceae: a literature review. ( 29872326 )
2018
46
Therapeutic effects of 5,2'-dibromo-2,4',5'-trihydroxydiphenylmethanone (LM49) in an experimental rat model of acute pyelonephritis by immunomodulation and anti-inflammation. ( 30007245 )
2018
47
Atypical Presentation of IgA Nephropathy Mimicking Acute Pyelonephritis. ( 30008750 )
2018
48
Studies on biofilm formation and virulence factors associated with uropathogenic Escherichia coli isolated from patient with acute pyelonephritis. ( 30032909 )
2018
49
Re: Acute Pyelonephritis in Adults. ( 30037528 )
2018
50
Acute pyelonephritis revealing an intraprostatic obstructive megaureter in an adult: A rare finding. ( 30144716 )
2018

Variations for Acute Pyelonephritis

Expression for Acute Pyelonephritis

Search GEO for disease gene expression data for Acute Pyelonephritis.

Pathways for Acute Pyelonephritis

Pathways related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
2
Show member pathways
13.01 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
3
Show member pathways
12.77 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
4
Show member pathways
12.66 CXCL10 CXCL8 CXCR1 CXCR2
5
Show member pathways
12.03 CXCL8 IL10 IL6 PGF
6
Show member pathways
12 CXCL10 CXCL8 CXCR1 CXCR2
7
Show member pathways
11.97 CXCL10 CXCL8 IL6
8 11.96 CXCL8 IL10 IL6
9
Show member pathways
11.85 CXCL8 IL10 IL6 PGF
10 11.81 CXCL10 CXCL8 IL6
11 11.78 CXCL8 IL10 IL6
12 11.67 CXCL8 IL10 IL6
13
Show member pathways
11.62 CXCL10 CXCL8 CXCR1 CXCR2
14 11.55 CXCL8 IL10 IL6
15 11.5 CXCL10 IL10 IL6
16 11.32 CXCL8 CXCR1 IL6
17 11.27 CXCL8 IL10 IL6
18 11.06 IL10 IL6
19 10.9 CXCL10 CXCL8 IL10 IL6
20 10.76 CXCL10 CXCL8 IL10 IL6 PGF
21 10.61 CXCL10 CXCL8 IL10 IL6
22 10.41 CRP CXCL8 IL6

GO Terms for Acute Pyelonephritis

Cellular components related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ADM ALB CRP CXCL10 CXCL8 IL10
2 extracellular space GO:0005615 9.23 ADM ALB CRP CXCL10 CXCL8 IL10

Biological processes related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 ALB CXCR2 IL10 IL6
2 negative regulation of cell proliferation GO:0008285 9.92 ADM CXCL8 IL10 IL6
3 positive regulation of cell proliferation GO:0008284 9.91 ADM CXCL10 CXCR2 IL6 PGF
4 cytokine-mediated signaling pathway GO:0019221 9.84 CXCL10 CXCL8 IL10 IL6
5 response to lipopolysaccharide GO:0032496 9.8 ADM CXCL10 IL10
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 ADM CXCR1 CXCR2
7 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL10 CXCL8 IL10 IL6
8 immune response GO:0006955 9.8 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
9 chemotaxis GO:0006935 9.78 CXCL10 CXCL8 CXCR1 CXCR2
10 positive regulation of angiogenesis GO:0045766 9.76 ADM CXCL8 CXCR2 PGF
11 calcium-mediated signaling GO:0019722 9.73 CXCL8 CXCR1 CXCR2
12 cell chemotaxis GO:0060326 9.72 CXCL10 CXCR1 CXCR2
13 response to glucocorticoid GO:0051384 9.7 ADM IL10 IL6
14 neutrophil chemotaxis GO:0030593 9.67 CXCL10 CXCL8 CXCR1 CXCR2
15 positive regulation of neutrophil chemotaxis GO:0090023 9.63 CXCL8 CXCR2
16 regulation of signaling receptor activity GO:0010469 9.63 ADM CXCL10 CXCL8 IL10 IL6 PGF
17 dendritic cell chemotaxis GO:0002407 9.61 CXCR1 CXCR2
18 induction of positive chemotaxis GO:0050930 9.61 CXCL8 PGF
19 response to molecule of bacterial origin GO:0002237 9.6 CXCL8 IL10
20 neutrophil activation GO:0042119 9.59 CXCL8 CXCR2
21 positive regulation of leukocyte chemotaxis GO:0002690 9.58 CXCR2 IL6
22 branching involved in labyrinthine layer morphogenesis GO:0060670 9.58 ADM IL10
23 leukocyte chemotaxis GO:0030595 9.58 CXCL10 CXCL8 IL10
24 negative regulation of lipid storage GO:0010888 9.57 CRP IL6
25 chemokine-mediated signaling pathway GO:0070098 9.56 CXCL10 CXCL8 CXCR1 CXCR2
26 interleukin-8-mediated signaling pathway GO:0038112 9.43 CXCR1 CXCR2
27 inflammatory response GO:0006954 9.43 CRP CXCL10 CXCL8 CXCR2 IL10 IL6
28 receptor internalization GO:0031623 8.92 ADM CXCL8 CXCR1 CXCR2
29 signal transduction GO:0007165 10.11 ADM CXCL10 CXCL8 CXCR1 CXCR2 PGF
30 G protein-coupled receptor signaling pathway GO:0007186 10.04 ADM CXCL10 CXCL8 CXCR1 CXCR2

Molecular functions related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.58 IL10 IL6 PGF
2 chemokine binding GO:0019956 9.46 CXCR1 CXCR2
3 cytokine activity GO:0005125 9.46 CXCL10 CXCL8 IL10 IL6
4 C-C chemokine binding GO:0019957 9.43 CXCR1 CXCR2
5 C-C chemokine receptor activity GO:0016493 9.37 CXCR1 CXCR2
6 chemokine receptor activity GO:0004950 9.32 CXCR1 CXCR2
7 C-X-C chemokine receptor activity GO:0016494 9.26 CXCR1 CXCR2
8 interleukin-8 binding GO:0019959 8.96 CXCR1 CXCR2
9 interleukin-8 receptor activity GO:0004918 8.62 CXCR1 CXCR2

Sources for Acute Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
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47 MGI
50 NCI
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55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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