MCID: ACT042
MIFTS: 46

Acute Pyelonephritis

Categories: Nephrological diseases

Aliases & Classifications for Acute Pyelonephritis

MalaCards integrated aliases for Acute Pyelonephritis:

Name: Acute Pyelonephritis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:559
ICD10 33 N10
ICD9CM 35 590.1
NCIt 50 C123215
UMLS 73 C0520575

Summaries for Acute Pyelonephritis

MalaCards based summary : Acute Pyelonephritis is related to cystitis and pyelitis. An important gene associated with Acute Pyelonephritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Ceftriaxone and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and neutrophil, and related phenotypes are cardiovascular system and immune system

Related Diseases for Acute Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Acute Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 235)
# Related Disease Score Top Affiliating Genes
1 cystitis 30.7 CRP CXCL8 IL6
2 pyelitis 30.4 CRP CXCR1
3 prostatitis 29.9 CXCL8 IL10 IL6
4 adult respiratory distress syndrome 29.9 CXCL8 IL10 IL6
5 cholangitis 29.9 ALB CRP IL6
6 bacteriuria 29.8 CXCL8 CXCR1 CXCR2 IL6
7 acute cystitis 29.6 ALB CRP CXCL8 IL6
8 septic arthritis 29.5 CRP CXCL8
9 acute kidney tubular necrosis 29.5 ALB NAGLU
10 brucellosis 29.3 CRP CXCL8 IL10 IL6
11 pneumonia 29.2 CRP CXCL8 IL10 IL6
12 placenta disease 29.2 CXCL8 IL6 PGF
13 kawasaki disease 29.0 ALB CRP IL10 IL6
14 rheumatoid arthritis 29.0 CRP CXCL8 IL10 IL6
15 pyelonephritis 26.9 ALB CRP CXCL8 CXCR1 CXCR2 IL10
16 cold agglutinin disease 10.9 CRP IL6
17 cryopyrin-associated periodic syndrome 10.8 CRP IL6
18 cardiogenic shock 10.8 CRP IL6
19 acute cholangitis 10.8 CRP IL6
20 neutrophilia, hereditary 10.8 CRP IL6
21 uremic pruritus 10.8 CRP IL6
22 spinal disease 10.8 CRP IL6
23 castleman disease 10.8 CRP IL6
24 recurrent corneal erosion 10.8 CXCL8 IL6
25 slow-channel congenital myasthenic syndrome 10.8 CRP CXCL8
26 bagassosis 10.8 CXCL8 IL6
27 angina pectoris 10.8 CRP IL6
28 viral pneumonia 10.8 CRP IL6
29 streptococcal toxic-shock syndrome 10.8 CXCL8 IL6
30 cecal disease 10.8 CRP IL6
31 relapsing polychondritis 10.7 CRP IL6
32 central nervous system vasculitis 10.7 CRP IL6
33 subacute thyroiditis 10.7 CRP IL6
34 papillary conjunctivitis 10.7 CXCL8 IL6
35 intussusception 10.7 CRP IL6
36 cardiac rupture 10.7 CRP CXCL8
37 acute monoblastic leukemia 10.7 CXCL8 IL6
38 meconium aspiration syndrome 10.7 CXCL8 IL6
39 ischemic heart disease 10.7 CRP IL6
40 mesenteric lymphadenitis 10.7 CRP IL6
41 vaginal disease 10.7 CXCL8 IL6
42 preterm premature rupture of the membranes 10.6 CXCL8 IL6
43 abdominal tuberculosis 10.6 ALB CRP
44 vaginitis 10.6 CXCL8 IL6
45 chronic ulcer of skin 10.6 ALB CRP
46 necrotizing fasciitis 10.6 CXCL8 IL6
47 decubitus ulcer 10.6 ALB CRP
48 euthyroid sick syndrome 10.6 ALB IL6
49 alexithymia 10.6 CRP IL6
50 eye lymphoma 10.6 IL10 IL6

Graphical network of the top 20 diseases related to Acute Pyelonephritis:



Diseases related to Acute Pyelonephritis

Symptoms & Phenotypes for Acute Pyelonephritis

MGI Mouse Phenotypes related to Acute Pyelonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 IL10 IL6 NAGLU PGF ADM CRP
2 immune system MP:0005387 9.81 IL6 NAGLU PGF ADM CRP CXCL10
3 liver/biliary system MP:0005370 9.43 IL10 IL6 NAGLU ADM ALB CXCR2
4 neoplasm MP:0002006 9.02 IL10 IL6 PGF ALB CXCR2

Drugs & Therapeutics for Acute Pyelonephritis

Drugs for Acute Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
2
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
3
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
4
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
5
Cefixime Approved, Investigational Phase 4 79350-37-1 54362 5362065
6
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
7
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
8
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
9
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 143 6006
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
11 Fluoroquinolones Phase 4,Phase 2
12 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2
13 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
14 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
15 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
17 Renal Agents Phase 4,Phase 3,Phase 2
18 Folic Acid Antagonists Phase 4,Phase 3
19 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2
20 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
21 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
22 Vitamin B Complex Phase 4,Phase 3
23 Lactams Phase 4
24 Antiparasitic Agents Phase 4,Phase 3
25 Antiprotozoal Agents Phase 4,Phase 3
26 Antitubercular Agents Phase 4,Phase 3,Not Applicable
27 Antimalarials Phase 4,Phase 3
28 Folate Nutraceutical Phase 4,Phase 3
29 Vitamin B9 Nutraceutical Phase 4,Phase 3
30
Tazobactam Approved Phase 3,Phase 2 89786-04-9 123630
31
Meropenem Approved, Investigational Phase 3 119478-56-7 64778 441130
32
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
33
Colistin Approved Phase 3 1264-72-8, 1066-17-7 5311054
34
Piperacillin Approved Phase 3,Phase 2 66258-76-2 43672
35
Tigecycline Approved Phase 3 220620-09-7 5282044
36
Fosfomycin Approved Phase 2, Phase 3 23155-02-4 446987
37
Ceftazidime Approved Phase 3 78439-06-2, 72558-82-8 5481173
38 Avibactam Approved Phase 3,Phase 2 1192500-31-4
39
Ceftibuten Approved, Investigational Phase 3 97519-39-6 5282241 5282242
40 Cephalosporins Phase 3,Phase 2
41 Thienamycins Phase 3
42 Penicillanic Acid Phase 3,Phase 2
43 Piperacillin, tazobactam drug combination Phase 3,Phase 2
44 beta-Lactamase Inhibitors Phase 3,Phase 2
45 Avibactam, ceftazidime drug combination Phase 3
46 carnitine Nutraceutical Phase 3
47 Omega 3 Fatty Acid Nutraceutical Phase 3
48
Ertapenem Approved, Investigational Phase 2 153832-46-3 150610
49
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
50
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old Completed NCT00136656 Phase 4 antibiotic;antibiotics
2 A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux Completed NCT00382343 Phase 4 Sulfamethoxazole/trimethoprim
3 Treatment's Duration of Acute Uncomplicated Pyelonephritis Completed NCT00873626 Phase 4 levofloxacin, ciprofloxacin and ofloxacin (fluoroquinolones)
4 Febrile Urinary Tract Infection Randomized Short Treatment Trial Completed NCT00809913 Phase 4 short treatment (ciprofloxacin)
5 Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women Completed NCT01390623 Phase 4 Ceftriaxone
6 Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis Recruiting NCT03179384 Phase 4 Ceftriaxone
7 L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis Unknown status NCT02007889 Phase 3 L-carnitine
8 Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in Children Unknown status NCT02192580 Phase 3 Omega-3
9 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01599806 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
10 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01595438 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
11 A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) Completed NCT02486627 Phase 3 plazomicin;meropenem;levofloxacin (oral)
12 A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. Completed NCT00210886 Phase 3 levofloxacin
13 Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP Completed NCT02166476 Phase 3 Meropenem-Vaborbactam;Piperacillin-Tazobactam;Levofloxacin;Saline
14 CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) Compared to Meropenem in Complicated Urinary Tract Infections (cUTIs) Caused by ESBL Producing Gram Negative Bacteria Completed NCT03477422 Phase 3 CSE-1034 (Ceftriaxone + Sulbactam + EDTA);Meropenem
15 Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections Completed NCT02753946 Phase 2, Phase 3 ZTI-01;Piperacillin-tazobactam
16 A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE) Completed NCT01970371 Phase 3 plazomicin;colistin;meropenem;tigecycline;antibiotic of Investigator's choice
17 Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults Completed NCT02168946 Phase 3 Vabomere;Best Available Therapy
18 Short-term Antibiotic Therapy for Pyelonephritis in Childhood Terminated NCT00724256 Phase 3 ceftibuten;ceftibuten
19 Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli Unknown status NCT02537847 Phase 2 Sitafloxacin;Ertapenem
20 Study of Plazomicin (ACHN-490) Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis Completed NCT01096849 Phase 2 levofloxacin;plazomicin;placebo
21 Effect of Acetylcysteine in Pediatric Acute Pyelonephritis. Completed NCT02080182 Phase 2 Acetylcysteine;placebo acetylcysteine
22 Finafloxacin for the Treatment of cUTI and/or Acute Pyelonephritis Completed NCT01928433 Phase 2 Finafloxacin 800 mg i.v. once daily;Finafloxacin placebo i.v. once daily;Finafloxacin 800 mg tablets once daily;Finafloxacin placebo tablets once daily;Ciprofloxacin 400 mg i.v. twice daily;Ciprofloxacin placebo i.v. twice daily;Ciprofloxacin 500 mg oral twice daily;Ciprofloxacin placebo oral twice daily
23 Evaluation of Safety and Efficacy of Intravenous Sulbactam-ETX2514 in the Treatment of Hospitalized Adults With Complicated Urinary Tract Infections Completed NCT03445195 Phase 2 Sulbactam-ETX2514;Placebo;Imipenem-cilastatin
24 Comparative Study of Coadministered Ceftaroline Fosamil and NXL104 vs. Intravenous Doripenem in Adult Subjects With Complicated Urinary Tract Infections Completed NCT01281462 Phase 2 Ceftaroline fosamil and NXL104 (q8h);Ceftaroline fosamil and NXL104 (q12h);Doripenem;Placebo
25 Prospective Study in the Emergency Terminated NCT01628900 Phase 2
26 GSK2251052 in Complicated Urinary Tract Infection Terminated NCT01381549 Phase 2 GSK2251052;imipenem-cilastatin
27 Proteinuria During Acute Pyelonephritis In Pregnancy Unknown status NCT02536638
28 Dexamethasone Administration in 1st Episode of Febrile Urinary Tract Infection Unknown status NCT02034851
29 Contrast-Enhanced US of Spleen, Liver and Kidney Unknown status NCT00190281
30 Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis Unknown status NCT00868270
31 Community-Associated Uropathogen Antimicrobial Resistance Among Emergency Department Patients With Acute Pyelonephritis Completed NCT01641029
32 Kinetics of Biomarkers in Acute Pyelonephritis Completed NCT00805181
33 Prospective Comparative Study About Treatment of Asymptomatic Bacteriuria in Kidney Transplant Recipients. Completed NCT02373085 Not Applicable
34 Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae Completed NCT02420366
35 Postlicensure Observational Safety Study of 13vPnC Administered to Infants and Toddlers Completed NCT01128426
36 Incidence of Post Cystography Urinary Tract Infections in the Pediatric Population Recruiting NCT03399682
37 Efficacy and Pharmacokinetic/Pharmacodynamic Parameters of Cefoxitin in Women With Acute Pyelonephritis Without Severity Symptoms Due to Extended-spectrum β-lactamase Producing Escherichia Coli Terminated NCT01820793 Not Applicable Cefoxitin
38 Bacterial and Host Genetic Risk Factors in Acute Pyelonephritis Withdrawn NCT01137929

Search NIH Clinical Center for Acute Pyelonephritis

Genetic Tests for Acute Pyelonephritis

Anatomical Context for Acute Pyelonephritis

MalaCards organs/tissues related to Acute Pyelonephritis:

41
Kidney, Liver, Neutrophil, Spleen, Testes, Colon, Prostate

Publications for Acute Pyelonephritis

Articles related to Acute Pyelonephritis:

(show top 50) (show all 640)
# Title Authors Year
1
Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis: A Multicenter, Randomized, Double-Blind, Phase 2 Study. ( 29378708 )
2018
2
Risk Factors for Uroseptic Shock in Patients with Urolithiasis-Related Acute Pyelonephritis. ( 29065405 )
2018
3
Diffusion tensor imaging in acute pyelonephritis in children. ( 29789888 )
2018
4
Acute Pyelonephritis in Adults. ( 29565517 )
2018
5
Outcome of children with ESBL-E. coli acute pyelonephritis treated with cephalosporins. ( 29746942 )
2018
6
Reply: Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637754 )
2018
7
Acute Pyelonephritis in Adults. ( 29298155 )
2018
8
D-dimer as a marker of acute pyelonephritis in infants younger than 24A months with urinary tract infection. ( 29306986 )
2018
9
Phylogenetic relationships, biofilm formation, motility, antibiotic resistance and extended virulence genotypes among Escherichia coli strains from women with community-onset primitive acute pyelonephritis. ( 29758033 )
2018
10
Re. "Diffusion weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: AA prospective study". ( 29778699 )
2018
11
Diffusion-weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: AA prospective study. ( 29588142 )
2018
12
Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637753 )
2018
13
Acute Pyelonephritis in Adults. ( 29562155 )
2018
14
Stopping the effective non-fluoroquinolone antibiotics at day 7 vs continuing until day 14 in adults with acute pyelonephritis requiring hospitalization: A randomized non-inferiority trial. ( 29768465 )
2018
15
Acute Pyelonephritis in Adults. ( 29539281 )
2018
16
The use of cefepime as a carbapenem-sparing antibiotic for treating uncomplicated acute pyelonephritis caused by extended-spectrum I^-lactamase producing Escherichia coli. ( 29086602 )
2018
17
Renal vein thrombosis complicating severe acute pyelonephritis with renal abscesses and associated bacteraemia caused by extended-spectrum beta-lactamase producing Escherichia coli. ( 29327131 )
2018
18
Mecillinam for the treatment of acute pyelonephritis and bacteremia caused by Enterobacteriaceae: a literature review. ( 29872326 )
2018
19
Mild encephalopathy with a reversible splenial lesion in a girl with acute pyelonephritis. ( 29563947 )
2018
20
Non-enhanced magnetic resonance imaging versus renal scintigraphy in acute pyelonephritis. ( 29473304 )
2018
21
Erratum: Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis [Corrigendum]. ( 29497327 )
2018
22
C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli. ( 29263309 )
2017
23
Neuroinvasive Infection from O117:K52:H-<i>Escherichia coli</i>following Acute Pyelonephritis. ( 29318066 )
2017
24
Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis. ( 28507449 )
2017
25
Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients. ( 27889429 )
2017
26
A randomized controlled trial of sitafloxacin vs. ertapenem as a switchA therapy after treatment for acute pyelonephritis caused by extended-spectrum I^-lactamase-producing Escherichia coli: A pilot study. ( 28587974 )
2017
27
Treatment of complicated urinary tract infection and acute pyelonephritis by short-course intravenous levofloxacin (750A mg/day) or conventional intravenous/oral levofloxacin (500A mg/day): prospective, open-label, randomized, controlled, multicenter, non-inferiority clinical trial. ( 28108978 )
2017
28
Transition Hand-Off from Inpatient to Outpatient Treatment of Acute Pyelonephritis in an Elderly Male. ( 28376986 )
2017
29
Imaging technologies in the diagnosis and treatment of acute pyelonephritis. ( 28525662 )
2017
30
Corticosteroids for renal scar prevention in children with acute pyelonephritis. ( 28404702 )
2017
31
Exploring the Anti-quorum Sensing and Antibiofilm Efficacy of Phytol against<i>Serratia marcescens</i>Associated Acute Pyelonephritis Infection in Wistar Rats. ( 29259923 )
2017
32
Ultrasonography of acute flank pain: a focus on renal stones and acute pyelonephritis. ( 29382187 )
2017
33
Acute Pyelonephritis - Correlation of Clinical Parameter with Radiological Imaging Abnormalities. ( 28764263 )
2017
34
A Cohort Study of Risk Factors That Influence Empirical Treatment of Patients with Acute Pyelonephritis. ( 28971876 )
2017
35
The role of nonautologous and autologous adipose-derived mesenchymal stem cell in acute pyelonephritis. ( 29218427 )
2017
36
Serial sonographic findings during progression from acute pyelonephritis to renal abscess: a rare case report. ( 28509119 )
2017
37
Prevention of Renal Scarring in Acute Pyelonephritis by Probiotic Therapy: an Experimental Study. ( 29204797 )
2017
38
Performance of qSOFA and SOFA for predicting mortality in patients with acute pyelonephritis associated with upper urinary tract calculi. ( 29291417 )
2017
39
Role of antioxidant defence, renal toxicity markers and inflammatory cascade in disease progression of acute pyelonephritis in experimental rat model. ( 28578087 )
2017
40
Electrolyte and Acid-Base Abnormalities in Infants with Community-Acquired Acute Pyelonephritis: Prospective Cross-Sectional Study. ( 28697495 )
2017
41
Usefulness of Blood Cultures and Radiologic Imaging Studies in the Management of Patients with Community-Acquired Acute Pyelonephritis. ( 28271650 )
2017
42
The climate impact on female acute pyelonephritis in Taiwan: AA population-based study. ( 28805597 )
2017
43
Splenic Abscess After Acute Pyelonephritis. ( 28215950 )
2017
44
Role of piperacillin/tazobactam as a carbapenem-sparing antibiotic for treatment of acute pyelonephritis due to extended-spectrum I^-lactamase-producing Escherichia coli. ( 28263710 )
2017
45
Qualitative and quantitative radiological analysis of non-contrast CT is a strong indicator in patients with acute pyelonephritis. ( 29055617 )
2017
46
Eliciting renal tenderness by sonopalpation in diagnosing acute pyelonephritis. ( 28050884 )
2017
47
Overuse of Diagnostic Testing in the Management of Korean Patients with Acute Pyelonephritis. ( 28332347 )
2017
48
Distinctive inflammatory profile between acute focal bacterial nephritis and acute pyelonephritis in children. ( 28683358 )
2017
49
18F-FDG PET/CT in Renal Infections: Evidence of Acute Pyelonephritis in a Horseshoe Kidney. ( 27879491 )
2017
50
Follow-up of acute pyelonephritis: what causes the diffusion-weighted magnetic resonance imaging recovery to lag clinical recovery? ( 28660334 )
2017

Variations for Acute Pyelonephritis

Expression for Acute Pyelonephritis

Search GEO for disease gene expression data for Acute Pyelonephritis.

Pathways for Acute Pyelonephritis

Pathways related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
2
Show member pathways
13.01 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
3
Show member pathways
12.76 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
4
Show member pathways
12.61 CXCL10 CXCL8 CXCR1 CXCR2
5
Show member pathways
11.93 CXCL10 CXCL8 IL6
6 11.91 CXCL8 IL10 IL6
7
Show member pathways
11.81 CXCL8 IL10 IL6 PGF
8 11.77 CXCL10 CXCL8 IL6
9 11.71 CXCL8 IL10 IL6
10 11.62 CXCL8 IL10 IL6
11
Show member pathways
11.62 CXCL10 CXCL8 CXCR1 CXCR2
12 11.49 CXCL8 IL10 IL6
13 11.29 CXCL8 CXCR1 IL6
14 11.23 CXCL8 IL10 IL6
15 11.04 IL10 IL6
16 10.61 CXCL10 CXCL8 IL10 IL6
17 10.41 CRP CXCL8 IL6

GO Terms for Acute Pyelonephritis

Cellular components related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ADM ALB CRP CXCL10 CXCL8 IL10
2 extracellular space GO:0005615 9.23 ADM ALB CRP CXCL10 CXCL8 IL10

Biological processes related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.92 ALB CXCR2 IL10 IL6
2 immune response GO:0006955 9.91 CXCL10 CXCL8 IL10 IL6
3 negative regulation of cell proliferation GO:0008285 9.9 ADM CXCL8 IL10 IL6
4 positive regulation of cell proliferation GO:0008284 9.89 ADM CXCL10 CXCR2 IL6 PGF
5 cytokine-mediated signaling pathway GO:0019221 9.85 CXCL10 CXCL8 IL10 IL6
6 response to lipopolysaccharide GO:0032496 9.78 ADM CXCL10 CXCL8 IL10
7 chemotaxis GO:0006935 9.76 CXCL10 CXCL8 CXCR1 CXCR2
8 positive regulation of angiogenesis GO:0045766 9.73 ADM CXCL8 CXCR2 PGF
9 regulation of signaling receptor activity GO:0010469 9.73 ADM CXCL10 CXCL8 IL10 IL6 PGF
10 response to glucocorticoid GO:0051384 9.69 ADM IL10 IL6
11 cellular response to lipopolysaccharide GO:0071222 9.67 CXCL10 CXCL8 IL10 IL6
12 inflammatory response GO:0006954 9.63 CRP CXCL10 CXCL8 CXCR2 IL10 IL6
13 chemokine-mediated signaling pathway GO:0070098 9.62 CXCL10 CXCL8 CXCR1 CXCR2
14 positive regulation of neutrophil chemotaxis GO:0090023 9.61 CXCL8 CXCR2
15 dendritic cell chemotaxis GO:0002407 9.59 CXCR1 CXCR2
16 induction of positive chemotaxis GO:0050930 9.58 CXCL8 PGF
17 response to molecule of bacterial origin GO:0002237 9.58 CXCL8 IL10
18 positive regulation of cAMP metabolic process GO:0030816 9.57 ADM CXCL10
19 neutrophil activation GO:0042119 9.56 CXCL8 CXCR2
20 negative regulation of lipid storage GO:0010888 9.54 CRP IL6
21 branching involved in labyrinthine layer morphogenesis GO:0060670 9.52 ADM IL10
22 interleukin-8-mediated signaling pathway GO:0038112 9.4 CXCR1 CXCR2
23 receptor internalization GO:0031623 9.26 ADM CXCL8 CXCR1 CXCR2
24 positive regulation of leukocyte chemotaxis GO:0002690 8.92 CXCL10 CXCL8 CXCR2 IL6
25 G-protein coupled receptor signaling pathway GO:0007186 10.02 ADM CXCL10 CXCL8 CXCR1 CXCR2

Molecular functions related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.58 IL10 IL6 PGF
2 cytokine activity GO:0005125 9.46 CXCL10 CXCL8 IL10 IL6
3 chemokine receptor activity GO:0004950 9.37 CXCR1 CXCR2
4 CXCR chemokine receptor binding GO:0045236 9.32 CXCL10 CXCL8
5 C-X-C chemokine receptor activity GO:0016494 9.26 CXCR1 CXCR2
6 interleukin-8 binding GO:0019959 8.96 CXCR1 CXCR2
7 interleukin-8 receptor activity GO:0004918 8.62 CXCR1 CXCR2

Sources for Acute Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....