MCID: ACT228
MIFTS: 30

Acute Radiation Syndrome

Categories: Rare diseases

Aliases & Classifications for Acute Radiation Syndrome

MalaCards integrated aliases for Acute Radiation Syndrome:

Name: Acute Radiation Syndrome 60
Acute Radiation Sickness 60

Characteristics:

Orphanet epidemiological data:

60
acute radiation syndrome
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

ICD10 via Orphanet 35 T66
Orphanet 60 ORPHA454831

Summaries for Acute Radiation Syndrome

MalaCards based summary : Acute Radiation Syndrome, also known as acute radiation sickness, is related to al-raqad syndrome and ewing's family of tumors. An important gene associated with Acute Radiation Syndrome is EPO (Erythropoietin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and JAK-STAT signaling pathway (KEGG). The drugs Interleukin-12 and Amifostine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and skin.

Wikipedia : 77 Acute radiation syndrome (ARS), also known as radiation sickness, is a collection of health effects due... more...

Related Diseases for Acute Radiation Syndrome

Diseases related to Acute Radiation Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 al-raqad syndrome 10.0
2 ewing's family of tumors 9.8 CSF3 EPO
3 anemia of prematurity 9.8 CSF3 EPO
4 pancytopenia 9.8 CSF3 EPO
5 deficiency anemia 9.8 CSF3 EPO
6 bone marrow cancer 9.8 CSF3 EPO
7 myelofibrosis 9.8 CSF3 EPO
8 myeloma, multiple 9.7 CSF3 EPO
9 leukemia, chronic myeloid 9.7 CSF3 EPO
10 aplastic anemia 9.7 CSF3 EPO
11 cystic fibrosis 9.6
12 leukemia, acute myeloid 9.6
13 leukemia 9.6
14 skin carcinoma 9.6
15 myeloid leukemia 9.6
16 myelodysplastic syndrome 9.6 CSF3 EPO
17 malaria 9.5 CSF3 EPO

Graphical network of the top 20 diseases related to Acute Radiation Syndrome:



Diseases related to Acute Radiation Syndrome

Symptoms & Phenotypes for Acute Radiation Syndrome

Drugs & Therapeutics for Acute Radiation Syndrome

Drugs for Acute Radiation Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin-12 Phase 2,Phase 1
2
Amifostine Approved, Investigational Phase 1 20537-88-6 2141
3
Iron Approved, Experimental Phase 1 7439-89-6, 15438-31-0 27284 23925
4 Chelating Agents Phase 1
5 Radiation-Protective Agents Phase 1
6 Protective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of HemaMax™ (rHuIL-12) to Treat Acute Radiation Syndrome Completed NCT02343133 Phase 2 Placebo
2 A Study to Evaluate the Safety and Pharmacokinetics of RadProtect® in Healthy Volunteers Unknown status NCT02587442 Phase 1 RadProtect®
3 Safety and Pharmacokinetic Study of BIO 300 Capsules Completed NCT00504335 Phase 1 BIO 300 Capsules
4 Safety and Tolerability of HemaMax™ (rHuIL-12) as Radiation Countermeasure Completed NCT01742221 Phase 1 Placebo
5 Phase I Study of Eltrombopag for Promoting Thrombopoiesis After Total Body Irradiation Completed NCT00903929 Phase 1 Eltrombopag
6 A Clinical Trial to Evaluate Safety, Tolerability and Pharmacokinetic/Pharmacodynamic Characteristics of KMRC011 Recruiting NCT03585803 Phase 1 KMRC011 5μg or Placebo;KMRC011 10μg or Placebo;KMRC011 20μg or Placebo;KMRC011 30μg or Placebo;KMRC011 45μg or Placebo;KMRC011 60μg or Placebo;KMRC011 75μg or Placebo
7 Open-label Phase I Study for PEP or Treatment of HS-ARS PLX-R18 for the Post-Exposure Prevention (PEP) or Treatment of Hematopoietic Syndrome of Acute Radiation Syndrome (HS-ARS) Not yet recruiting NCT03797040 Phase 1
8 Parental Irradiation of Ukrainian Cleanup Workers and Evacuees and Germline Mutations in Their Offspring (Trio Study) Recruiting NCT02566161

Search NIH Clinical Center for Acute Radiation Syndrome

Genetic Tests for Acute Radiation Syndrome

Anatomical Context for Acute Radiation Syndrome

MalaCards organs/tissues related to Acute Radiation Syndrome:

42
Myeloid, Bone, Skin, Liver, Testes, Spleen, Small Intestine

Publications for Acute Radiation Syndrome

Articles related to Acute Radiation Syndrome:

(show top 50) (show all 186)
# Title Authors Year
1
Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome. ( 31038675 )
2019
2
Modeling the Optimum Prussian Blue Treatment for Acute Radiation Syndrome Following 137Cs Ingestion. ( 30489370 )
2019
3
Neulasta Regimen for the Hematopoietic Acute Radiation Syndrome: Effects Beyond Neutrophil Recovery. ( 30496878 )
2019
4
The Gastrointestinal Subsyndrome of the Acute Radiation Syndrome in Rhesus Macaques: A Systematic Review of the Lethal Dose-Response Relationship With and Without Medical Management. ( 30624353 )
2019
5
Proteomic Evaluation of the Acute Radiation Syndrome of the Gastrointestinal Tract in a Murine Total-body Irradiation Model. ( 30624357 )
2019
6
Characterizing the Natural History of Acute Radiation Syndrome of the Gastrointestinal Tract: Combining High Mass and Spatial Resolution Using MALDI-FTICR-MSI. ( 30681424 )
2019
7
Effect of Sex on Biomarker Response in a Mouse Model of the Hematopoietic Acute Radiation Syndrome. ( 30681425 )
2019
8
Lifelong Residual bone Marrow Damage in Murine Survivors of the Hematopoietic Acute Radiation Syndrome (H-ARS): A Compilation of Studies Comprising the Indiana University Experience. ( 30789496 )
2019
9
Are animal models a necessity for acute radiation syndrome drug discovery? ( 30870041 )
2019
10
Drug discovery strategies for acute radiation syndrome. ( 31008662 )
2019
11
Cholinergic and cytoprotective signaling cascades mediate the mitigative effect of erythropoietin on acute radiation syndrome. ( 29220591 )
2018
12
Medical management of acute radiation syndrome and associated infections in a high-casualty incident. ( 29509947 )
2018
13
Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome. ( 29634408 )
2018
14
Survival of Mice with Gastrointestinal Acute Radiation Syndrome through Control of Bacterial Translocation. ( 29743312 )
2018
15
Use of Proteomic and Hematology Biomarkers for Prediction of Hematopoietic Acute Radiation Syndrome Severity in Baboon Radiation Models. ( 29787428 )
2018
16
PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome. ( 29787432 )
2018
17
Selective Insulin-like Growth Factor Resistance Associated with Heart Hemorrhages and Poor Prognosis in a Novel Preclinical Model of the Hematopoietic Acute Radiation Syndrome. ( 29809108 )
2018
18
ACUTE MYELOID LEUKEMIA, PROSTATE AND SKIN CANCER IN ACUTE RADIATION SYNDROME SURVIVOR AFTER THE 1986 CHERNOBYL NUCLEAR ACCIDENT: CASE REPORT. ( 30137627 )
2018
19
Nonhuman Primates with Acute Radiation Syndrome: Results from a Global Serum Metabolomics Study after 7.2 Gy Total-Body Irradiation. ( 30183511 )
2018
20
Acute radiation syndrome in a non-destructive testing worker: a case report. ( 30263125 )
2018
21
Opportunities and challenges with animal models for acute radiation syndrome drug discovery. ( 30269616 )
2018
22
Biomarkers for acute radiation syndrome: challenges for developing radiation countermeasures following animal rule. ( 30289289 )
2018
23
AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice. ( 30302025 )
2018
24
System for Scoring Severity of Acute Radiation Syndrome Response in Rhesus Macaques (Macaca mulatta). ( 30305197 )
2018
25
Rescue from lethal acute radiation syndrome (ARS) with severe weight loss by secretome of intramuscularly injected human placental stromal cells. ( 30334381 )
2018
26
A comparative analysis of gut microbiota disturbances in the Gottingen minipig and rhesus macaque models of acute radiation syndrome following bioequivalent radiation exposures. ( 30343431 )
2018
27
COORDINATION OF MANAGEMENT OF THE ACUTE RADIATION SYNDROME. ( 30418654 )
2018
28
An update on sargramostim for treatment of acute radiation syndrome. ( 30539167 )
2018
29
MORPHOMETRIC PARAMETERS OF RETINAL MACULAR ZONE IN RECONVALESCENTS OF ACUTE RADIATION SICKNESS (IN REMOTE PERIOD). ( 30582865 )
2018
30
The Regenerative Effect of Bone Marrow-Derived Stem Cells on Cell Count and Survival in Acute Radiation Syndrome. ( 28289623 )
2017
31
A sharp, robust, and quantitative method by liquid chromatography tandem mass spectrometry for the measurement of EAD for acute radiation syndrome and its application. ( 28445846 )
2017
32
Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review. ( 28534834 )
2017
33
Rapid Prediction of Hematologic Acute Radiation Syndrome in Radiation Injury Patients Using Peripheral Blood Cell Counts. ( 28590841 )
2017
34
Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma. ( 28850300 )
2017
35
Estimating Risk of Hematopoietic Acute Radiation Syndrome in Children. ( 28968347 )
2017
36
The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome. ( 29230065 )
2017
37
γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status. ( 27153057 )
2016
38
Mesenchymal stem cell therapy for acute radiation syndrome. ( 27182446 )
2016
39
Association of Acute Radiation Syndrome and Rain after the Bombings in Atomic Bomb Survivors. ( 27223827 )
2016
40
First Generation Gene Expression Signature for Early Prediction of Late Occurring Hematological Acute Radiation Syndrome in Baboons. ( 27333084 )
2016
41
Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects. ( 27351760 )
2016
42
Acute Radiation Syndrome Severity Score System in Mouse Total-Body Irradiation Model. ( 27356057 )
2016
43
The healing effect of bone marrow-derived stem cells in acute radiation syndrome. ( 27375707 )
2016
44
Linking Doses with Clinical Scores of Hematopoietic Acute Radiation Syndrome. ( 27575346 )
2016
45
MicroRNA Expression for Early Prediction of Late Occurring Hematologic Acute Radiation Syndrome in Baboons. ( 27846229 )
2016
46
Detection of Acute Radiation Sickness: A Feasibility Study in Non-Human Primates Circulating miRNAs for Triage in Radiological Events. ( 27907140 )
2016
47
Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness. ( 28230827 )
2016
48
Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): a review. ( 25215458 )
2015
49
Biologics as countermeasures for acute radiation syndrome: where are we now? ( 25416452 )
2015
50
Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells. ( 25618561 )
2015

Variations for Acute Radiation Syndrome

Expression for Acute Radiation Syndrome

Search GEO for disease gene expression data for Acute Radiation Syndrome.

Pathways for Acute Radiation Syndrome

Pathways related to Acute Radiation Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.16 CSF3 EPO
2
Show member pathways
11.62 CSF3 EPO
3 11.22 CSF3 EPO
4 10.94 CSF3 EPO
5 10.3 CSF3 EPO

GO Terms for Acute Radiation Syndrome

Biological processes related to Acute Radiation Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.16 CSF3 EPO
2 regulation of signaling receptor activity GO:0010469 8.96 CSF3 EPO
3 negative regulation of neuron death GO:1901215 8.62 CSF3 EPO

Molecular functions related to Acute Radiation Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.62 CSF3 EPO

Sources for Acute Radiation Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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