MCID: ACT228
MIFTS: 29

Acute Radiation Syndrome

Categories: Rare diseases

Aliases & Classifications for Acute Radiation Syndrome

MalaCards integrated aliases for Acute Radiation Syndrome:

Name: Acute Radiation Syndrome 59
Acute Radiation Sickness 59

Characteristics:

Orphanet epidemiological data:

59
acute radiation syndrome
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Orphanet 59 ORPHA454831
ICD10 via Orphanet 34 T66

Summaries for Acute Radiation Syndrome

MalaCards based summary : Acute Radiation Syndrome, also known as acute radiation sickness, is related to ewing's family of tumors and anemia of prematurity. An important gene associated with Acute Radiation Syndrome is EPO (Erythropoietin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and JAK-STAT signaling pathway (KEGG). The drugs Interleukin-12 and Iron have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and skin.

Wikipedia : 76 Acute radiation syndrome (ARS) is a collection of health effects that are present within 24 hours of... more...

Related Diseases for Acute Radiation Syndrome

Diseases related to Acute Radiation Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 ewing's family of tumors 9.9 CSF3 EPO
2 anemia of prematurity 9.9 CSF3 EPO
3 pancytopenia 9.9 CSF3 EPO
4 deficiency anemia 9.9 CSF3 EPO
5 bone marrow cancer 9.9 CSF3 EPO
6 myelofibrosis 9.8 CSF3 EPO
7 myeloma, multiple 9.8 CSF3 EPO
8 leukemia, chronic myeloid 9.8 CSF3 EPO
9 aplastic anemia 9.8 CSF3 EPO
10 al-raqad syndrome 9.8
11 myelodysplastic syndrome 9.8 CSF3 EPO
12 malaria 9.7 CSF3 EPO
13 leukemia, acute myeloid 9.6
14 leukemia 9.6
15 myeloid leukemia 9.6

Graphical network of the top 20 diseases related to Acute Radiation Syndrome:



Diseases related to Acute Radiation Syndrome

Symptoms & Phenotypes for Acute Radiation Syndrome

Drugs & Therapeutics for Acute Radiation Syndrome

Drugs for Acute Radiation Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin-12 Phase 2
2
Iron Approved Phase 1 7439-89-6 23925
3
Amifostine Approved, Investigational Phase 1 20537-88-6 2141
4 Radiation-Protective Agents Phase 1
5 Protective Agents Phase 1
6 Chelating Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of HemaMax™ (rHuIL-12) to Treat Acute Radiation Syndrome Completed NCT02343133 Phase 2 Placebo
2 A Study to Evaluate the Safety and Pharmacokinetics of RadProtect® in Healthy Volunteers Unknown status NCT02587442 Phase 1 RadProtect®
3 Safety and Pharmacokinetic Study of BIO 300 Capsules Completed NCT00504335 Phase 1 BIO 300 Capsules
4 Safety and Tolerability of HemaMax™ (rHuIL-12) as Radiation Countermeasure Completed NCT01742221 Phase 1 Placebo
5 Phase I Study of Eltrombopag for Promoting Thrombopoiesis After Total Body Irradiation Completed NCT00903929 Phase 1 Eltrombopag
6 A Clinical Trial to Evaluate Safety, Tolerability and Pharmacokinetic/Pharmacodynamic Characteristics of KMRC011 Recruiting NCT03585803 Phase 1 KMRC011 5μg or Placebo;KMRC011 10μg or Placebo;KMRC011 20μg or Placebo;KMRC011 30μg or Placebo;KMRC011 45μg or Placebo;KMRC011 60μg or Placebo;KMRC011 75μg or Placebo
7 Open-label Phase I Study for PEP or Treatment of HS-ARS PLX-R18 for the Post-Exposure Prevention (PEP) or Treatment of Hematopoietic Syndrome of Acute Radiation Syndrome (HS-ARS) Not yet recruiting NCT03797040 Phase 1
8 Parental Irradiation of Ukrainian Cleanup Workers and Evacuees and Germline Mutations in Their Offspring (Trio Study) Recruiting NCT02566161

Search NIH Clinical Center for Acute Radiation Syndrome

Genetic Tests for Acute Radiation Syndrome

Anatomical Context for Acute Radiation Syndrome

MalaCards organs/tissues related to Acute Radiation Syndrome:

41
Bone, Liver, Skin, Spleen, Myeloid, Small Intestine, Bone Marrow

Publications for Acute Radiation Syndrome

Articles related to Acute Radiation Syndrome:

(show top 50) (show all 176)
# Title Authors Year
1
Modeling the Optimum Prussian Blue Treatment for Acute Radiation Syndrome Following 137Cs Ingestion. ( 30489370 )
2019
2
Survival of Mice with Gastrointestinal Acute Radiation Syndrome through Control of Bacterial Translocation. ( 29743312 )
2018
3
Medical management of acute radiation syndrome and associated infections in a high-casualty incident. ( 29509947 )
2018
4
Selective Insulin-like Growth Factor Resistance Associated with Heart Hemorrhages and Poor Prognosis in a Novel Preclinical Model of the Hematopoietic Acute Radiation Syndrome. ( 29809108 )
2018
5
Use of Proteomic and Hematology Biomarkers for Prediction of Hematopoietic Acute Radiation Syndrome Severity in Baboon Radiation Models. ( 29787428 )
2018
6
PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome. ( 29787432 )
2018
7
Cholinergic and cytoprotective signaling cascades mediate the mitigative effect of erythropoietin on acute radiation syndrome. ( 29220591 )
2018
8
Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome. ( 29634408 )
2018
9
ACUTE MYELOID LEUKEMIA, PROSTATE AND SKIN CANCER IN ACUTE RADIATION SYNDROME SURVIVOR AFTER THE 1986 CHERNOBYL NUCLEAR ACCIDENT: CASE REPORT. ( 30137627 )
2018
10
Nonhuman Primates with Acute Radiation Syndrome: Results from a Global Serum Metabolomics Study after 7.2 Gy Total-Body Irradiation. ( 30183511 )
2018
11
Acute radiation syndrome in a non-destructive testing worker: a case report. ( 30263125 )
2018
12
Opportunities and challenges with animal models for acute radiation syndrome drug discovery. ( 30269616 )
2018
13
Biomarkers for acute radiation syndrome: challenges for developing radiation countermeasures following animal rule. ( 30289289 )
2018
14
AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice. ( 30302025 )
2018
15
System for Scoring Severity of Acute Radiation Syndrome Response in Rhesus Macaques (Macaca mulatta). ( 30305197 )
2018
16
Rescue from lethal acute radiation syndrome (ARS) with severe weight loss by secretome of intramuscularly injected human placental stromal cells. ( 30334381 )
2018
17
A comparative analysis of gut microbiota disturbances in the Gottingen minipig and rhesus macaque models of acute radiation syndrome following bioequivalent radiation exposures. ( 30343431 )
2018
18
COORDINATION OF MANAGEMENT OF THE ACUTE RADIATION SYNDROME. ( 30418654 )
2018
19
An update on sargramostim for treatment of acute radiation syndrome. ( 30539167 )
2018
20
Estimating Risk of Hematopoietic Acute Radiation Syndrome in Children. ( 28968347 )
2017
21
The Regenerative Effect of Bone Marrow-Derived Stem Cells on Cell Count and Survival in Acute Radiation Syndrome. ( 28289623 )
2017
22
A sharp, robust, and quantitative method by liquid chromatography tandem mass spectrometry for the measurement of EAD for acute radiation syndrome and its application. ( 28445846 )
2017
23
Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review. ( 28534834 )
2017
24
The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome. ( 29230065 )
2017
25
Rapid Prediction of Hematologic Acute Radiation Syndrome in Radiation Injury Patients Using Peripheral Blood Cell Counts. ( 28590841 )
2017
26
Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma. ( 28850300 )
2017
27
Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects. ( 27351760 )
2016
28
MicroRNA Expression for Early Prediction of Late Occurring Hematologic Acute Radiation Syndrome in Baboons. ( 27846229 )
2016
29
I^-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status. ( 27153057 )
2016
30
Linking Doses with Clinical Scores of Hematopoietic Acute Radiation Syndrome. ( 27575346 )
2016
31
The healing effect of bone marrow-derived stem cells in acute radiation syndrome. ( 27375707 )
2016
32
Acute Radiation Syndrome Severity Score System in Mouse Total-Body Irradiation Model. ( 27356057 )
2016
33
Association of Acute Radiation Syndrome and Rain after the Bombings in Atomic Bomb Survivors. ( 27223827 )
2016
34
First Generation Gene Expression Signature for Early Prediction of Late Occurring Hematological Acute Radiation Syndrome in Baboons. ( 27333084 )
2016
35
Mesenchymal stem cell therapy for acute radiation syndrome. ( 27182446 )
2016
36
Detection of Acute Radiation Sickness: A Feasibility Study in Non-Human Primates Circulating miRNAs for Triage in Radiological Events. ( 27907140 )
2016
37
Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness. ( 28230827 )
2016
38
Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells. ( 25618561 )
2015
39
The Hematopoietic Syndrome of the Acute Radiation Syndrome in Rhesus Macaques: A Systematic Review of the Lethal Dose Response Relationship. ( 26425897 )
2015
40
The Delayed Effects of Acute Radiation Syndrome: Evidence of Long-Term Functional Changes in the Clonogenic Cells of the Small Intestine. ( 26425901 )
2015
41
The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice. ( 25738896 )
2015
42
Mitigation of the hematopoietic and gastrointestinal acute radiation syndrome by octadecenyl thiophosphate, a small molecule mimic of lysophosphatidic acid. ( 25807318 )
2015
43
Animal models for acute radiation syndrome drug discovery. ( 25819367 )
2015
44
The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates. ( 26367124 )
2015
45
Mesenchymal stem cell therapy for acute radiation syndrome: innovative medical approaches in military medicine. ( 25722881 )
2015
46
Biologics as countermeasures for acute radiation syndrome: where are we now? ( 25416452 )
2015
47
Filgrastim for the treatment of hematopoietic acute radiation syndrome. ( 26488033 )
2015
48
Protracted Oxidative Alterations in the Mechanism of Hematopoietic Acute Radiation Syndrome. ( 26785342 )
2015
49
The MCART Consortium Animal Model Series: MCART Animal Model Refinement and MCM Development: Defining organ dose, organ-specific tissue imaging, model validation and the natural history between the acute radiation syndrome (ARS) and the delayed effects of acute radiation exposure (DEARE). ( 26425896 )
2015
50
Association of Hematological Nadirs and Survival in a Nonhuman Primate Model of Hematopoietic Syndrome of Acute Radiation Syndrome. ( 26207689 )
2015

Variations for Acute Radiation Syndrome

Expression for Acute Radiation Syndrome

Search GEO for disease gene expression data for Acute Radiation Syndrome.

Pathways for Acute Radiation Syndrome

Pathways related to Acute Radiation Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.16 CSF3 EPO
2
Show member pathways
11.62 CSF3 EPO
3 11.22 CSF3 EPO
4 10.94 CSF3 EPO
5 10.3 CSF3 EPO

GO Terms for Acute Radiation Syndrome

Biological processes related to Acute Radiation Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.16 CSF3 EPO
2 regulation of signaling receptor activity GO:0010469 8.96 CSF3 EPO
3 negative regulation of neuron death GO:1901215 8.62 CSF3 EPO

Molecular functions related to Acute Radiation Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.62 CSF3 EPO

Sources for Acute Radiation Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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