MCID: ACT228
MIFTS: 17

Acute Radiation Syndrome

Categories: Rare diseases

Aliases & Classifications for Acute Radiation Syndrome

MalaCards integrated aliases for Acute Radiation Syndrome:

Name: Acute Radiation Syndrome 59
Acute Radiation Sickness 59

Characteristics:

Orphanet epidemiological data:

59
acute radiation syndrome
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Orphanet 59 ORPHA454831
ICD10 via Orphanet 34 T66

Summaries for Acute Radiation Syndrome

MalaCards based summary : Acute Radiation Syndrome, is also known as acute radiation sickness. An important gene associated with Acute Radiation Syndrome is CSF3 (Colony Stimulating Factor 3). The drugs Interleukin-12 and Iron have been mentioned in the context of this disorder. Affiliated tissues include bone, small intestine and heart.

Wikipedia : 76 Acute radiation syndrome (ARS) is a collection of health effects that are present within 24 hours of... more...

Related Diseases for Acute Radiation Syndrome

Symptoms & Phenotypes for Acute Radiation Syndrome

Drugs & Therapeutics for Acute Radiation Syndrome

Drugs for Acute Radiation Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin-12 Phase 2
2
Iron Approved Phase 1 7439-89-6 23925
3
Amifostine Approved, Investigational Phase 1 20537-88-6 2141
4 Chelating Agents Phase 1
5 Protective Agents Phase 1
6 Radiation-Protective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of HemaMax™ (rHuIL-12) to Treat Acute Radiation Syndrome Completed NCT02343133 Phase 2
2 A Study to Evaluate the Safety and Pharmacokinetics of RadProtect® in Healthy Volunteers Unknown status NCT02587442 Phase 1 RadProtect®
3 Safety and Tolerability of HemaMax™ (rHuIL-12) as Radiation Countermeasure Completed NCT01742221 Phase 1
4 Safety and Pharmacokinetic Study of BIO 300 Capsules Completed NCT00504335 Phase 1 BIO 300 Capsules
5 Phase I Study of Eltrombopag for Promoting Thrombopoiesis After Total Body Irradiation Completed NCT00903929 Phase 1 Eltrombopag
6 Parental Irradiation of Ukrainian Cleanup Workers and Evacuees and Germline Mutations in Their Offspring (Trio Study) Recruiting NCT02566161

Search NIH Clinical Center for Acute Radiation Syndrome

Genetic Tests for Acute Radiation Syndrome

Anatomical Context for Acute Radiation Syndrome

MalaCards organs/tissues related to Acute Radiation Syndrome:

41
Bone, Small Intestine, Heart

Publications for Acute Radiation Syndrome

Articles related to Acute Radiation Syndrome:

(show all 45)
# Title Authors Year
1
Survival of Mice with Gastrointestinal Acute Radiation Syndrome through Control of Bacterial Translocation. ( 29743312 )
2018
2
Medical management of acute radiation syndrome and associated infections in a high-casualty incident. ( 29509947 )
2018
3
Selective Insulin-like Growth Factor Resistance Associated with Heart Hemorrhages and Poor Prognosis in a Novel Preclinical Model of the Hematopoietic Acute Radiation Syndrome. ( 29809108 )
2018
4
Use of Proteomic and Hematology Biomarkers for Prediction of Hematopoietic Acute Radiation Syndrome Severity in Baboon Radiation Models. ( 29787428 )
2018
5
PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome. ( 29787432 )
2018
6
Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome. ( 29634408 )
2018
7
Estimating Risk of Hematopoietic Acute Radiation Syndrome in Children. ( 28968347 )
2017
8
The Regenerative Effect of Bone Marrow-Derived Stem Cells on Cell Count and Survival in Acute Radiation Syndrome. ( 28289623 )
2017
9
A sharp, robust, and quantitative method by liquid chromatography tandem mass spectrometry for the measurement of EAD for acute radiation syndrome and its application. ( 28445846 )
2017
10
Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review. ( 28534834 )
2017
11
The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome. ( 29230065 )
2017
12
Cholinergic and cytoprotective signaling cascades mediate the mitigative effect of erythropoietin on acute radiation syndrome. ( 29220591 )
2017
13
Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation alone and Followed by Wound Trauma. ( 28850300 )
2017
14
Rapid Prediction of Hematologic Acute Radiation Syndrome in Radiation Injury Patients Using Peripheral Blood Cell Counts. ( 28590841 )
2017
15
Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects. ( 27351760 )
2016
16
MicroRNA Expression for Early Prediction of Late Occurring Hematologic Acute Radiation Syndrome in Baboons. ( 27846229 )
2016
17
I^-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status. ( 27153057 )
2016
18
Linking Doses with Clinical Scores of Hematopoietic Acute Radiation Syndrome. ( 27575346 )
2016
19
The healing effect of bone marrow-derived stem cells in acute radiation syndrome. ( 27375707 )
2016
20
Acute Radiation Syndrome Severity Score System in Mouse Total-Body Irradiation Model. ( 27356057 )
2016
21
Association of Acute Radiation Syndrome and Rain after the Bombings in Atomic Bomb Survivors. ( 27223827 )
2016
22
First Generation Gene Expression Signature for Early Prediction of Late Occurring Hematological Acute Radiation Syndrome in Baboons. ( 27333084 )
2016
23
Mesenchymal stem cell therapy for acute radiation syndrome. ( 27182446 )
2016
24
Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells. ( 25618561 )
2015
25
The Hematopoietic Syndrome of the Acute Radiation Syndrome in Rhesus Macaques: A Systematic Review of the Lethal Dose Response Relationship. ( 26425897 )
2015
26
The Delayed Effects of Acute Radiation Syndrome: Evidence of Long-Term Functional Changes in the Clonogenic Cells of the Small Intestine. ( 26425901 )
2015
27
The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice. ( 25738896 )
2015
28
Mitigation of the hematopoietic and gastrointestinal acute radiation syndrome by octadecenyl thiophosphate, a small molecule mimic of lysophosphatidic acid. ( 25807318 )
2015
29
Animal models for acute radiation syndrome drug discovery. ( 25819367 )
2015
30
The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates. ( 26367124 )
2015
31
Mesenchymal stem cell therapy for acute radiation syndrome: innovative medical approaches in military medicine. ( 25722881 )
2015
32
Biologics as countermeasures for acute radiation syndrome: where are we now? ( 25416452 )
2015
33
Filgrastim for the treatment of hematopoietic acute radiation syndrome. ( 26488033 )
2015
34
Protracted Oxidative Alterations in the Mechanism of Hematopoietic Acute Radiation Syndrome. ( 26785342 )
2015
35
The MCART Consortium Animal Model Series: MCART Animal Model Refinement and MCM Development: Defining organ dose, organ-specific tissue imaging, model validation and the natural history between the acute radiation syndrome (ARS) and the delayed effects of acute radiation exposure (DEARE). ( 26425896 )
2015
36
Association of Hematological Nadirs and Survival in a Nonhuman Primate Model of Hematopoietic Syndrome of Acute Radiation Syndrome. ( 26207689 )
2015
37
Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): a review. ( 25215458 )
2015
38
CCM-AMI, a Polyethylene Glycol Micelle with Amifostine, as an Acute Radiation Syndrome Protectant in C57BL/6 Mice. ( 26222219 )
2015
39
Patents for Toll-like receptor ligands as radiation countermeasures for acute radiation syndrome. ( 26135043 )
2015
40
Radioprotective effect of Rapana thomasiana hemocyanin in gamma induced acute radiation syndrome. ( 26019540 )
2014
41
Gastrointestinal acute radiation syndrome in GAPttingen minipigs (Sus scrofa domestica). ( 25527026 )
2014
42
Acute radiation syndrome (ARS) - treatment of the reduced host defense. ( 22319248 )
2012
43
Comparison of autologous cell therapy and granulocyte-colony stimulating factor (G-CSF) injection vs. G-CSF injection alone for the treatment of acute radiation syndrome in a non-human primate model. ( 15913916 )
2005
44
Which place for stem cell therapy in the treatment of acute radiation syndrome? ( 16382889 )
2005
45
[Colony stimulating factors as a treatment modality for acute radiation syndrome]. ( 1505827 )
1992

Variations for Acute Radiation Syndrome

Expression for Acute Radiation Syndrome

Search GEO for disease gene expression data for Acute Radiation Syndrome.

Pathways for Acute Radiation Syndrome

GO Terms for Acute Radiation Syndrome

Sources for Acute Radiation Syndrome

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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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