MCID: ACT228
MIFTS: 30

Acute Radiation Syndrome

Categories: Rare diseases

Aliases & Classifications for Acute Radiation Syndrome

MalaCards integrated aliases for Acute Radiation Syndrome:

Name: Acute Radiation Syndrome 58
Acute Radiation Sickness 58

Characteristics:

Orphanet epidemiological data:

58
acute radiation syndrome
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

ICD10 via Orphanet 33 T66
Orphanet 58 ORPHA454831

Summaries for Acute Radiation Syndrome

MalaCards based summary : Acute Radiation Syndrome, also known as acute radiation sickness, is related to neutropenia and pancytopenia. An important gene associated with Acute Radiation Syndrome is CSF3 (Colony Stimulating Factor 3), and among its related pathways/superpathways are PI3K-Akt signaling pathway and JAK-STAT signaling pathway. The drugs Interleukin-12 and Iron have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and small intestine.

Wikipedia : 73 Acute radiation syndrome (ARS), also known as radiation sickness or radiation poisoning, is a collection... more...

Related Diseases for Acute Radiation Syndrome

Diseases related to Acute Radiation Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 neutropenia 30.0 EPO CSF3
2 pancytopenia 29.8 EPO CSF3
3 thrombocytopenia 29.8 EPO CSF3
4 blood coagulation disease 29.7 EPO CSF3
5 myelodysplastic syndrome 29.1 EPO CSF3
6 leukemia, acute myeloid 28.9 EPO CSF3
7 cataract 10.2
8 dystonia 10.1
9 lymphopenia 10.1
10 macular degeneration, age-related, 1 10.0
11 disseminated intravascular coagulation 10.0
12 bronchopneumonia 10.0
13 amenorrhea 10.0
14 candidiasis 10.0
15 tularemia 10.0
16 skin atrophy 10.0
17 syphilis 10.0
18 brain edema 10.0
19 thyroid gland disease 10.0
20 pneumonia 10.0
21 anthrax disease 10.0
22 gastrointestinal system disease 10.0
23 myocarditis 10.0
24 diarrhea 9.9
25 refractory anemia 9.9 EPO CSF3
26 miliary tuberculosis 9.9 EPO CSF3
27 retinitis pigmentosa and erythrocytic microcytosis 9.8 EPO CSF3
28 poems syndrome 9.8 EPO CSF3
29 hypersplenism 9.8 EPO CSF3
30 hemoglobinuria 9.8 EPO CSF3
31 pulmonary edema 9.8 EPO CSF3
32 thrombocytosis 9.8 EPO CSF3
33 paroxysmal nocturnal hemoglobinuria 9.8 EPO CSF3
34 blood platelet disease 9.8 EPO CSF3
35 bilirubin metabolic disorder 9.8 EPO CSF3
36 bone marrow cancer 9.8 EPO CSF3
37 polycythemia vera 9.8 EPO CSF3
38 sickle cell anemia 9.8 EPO CSF3
39 essential thrombocythemia 9.8 EPO CSF3
40 myeloproliferative neoplasm 9.8 EPO CSF3
41 ataxia-telangiectasia 9.8
42 citrullinemia, classic 9.8
43 ataxia and polyneuropathy, adult-onset 9.8
44 pigmentation disease 9.8
45 leukemia 9.8
46 telangiectasis 9.8
47 duodenal ulcer 9.8
48 viral hepatitis 9.8
49 skin carcinoma 9.8
50 systemic scleroderma 9.8

Graphical network of the top 20 diseases related to Acute Radiation Syndrome:



Diseases related to Acute Radiation Syndrome

Symptoms & Phenotypes for Acute Radiation Syndrome

Drugs & Therapeutics for Acute Radiation Syndrome

Drugs for Acute Radiation Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin-12 Phase 2
2
Iron Approved Phase 1 7439-89-6 23925 29936
3
Amifostine Approved, Investigational Phase 1 20537-88-6 2141
4
Genistein Investigational Phase 1 446-72-0 5280961
5 Chelating Agents Phase 1
6 Protective Agents Phase 1
7 Hormones Phase 1
8 Phytoestrogens Phase 1
9 Hormone Antagonists Phase 1
10 Estrogens Phase 1
11 Protein Kinase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Single-Dose, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HemaMax™ (rHuIL-12) in Healthy Subjects Completed NCT02343133 Phase 2 Placebo
2 A Phase I Study to Evaluate the Safety and Pharmacokinetics of RadProtect® in Healthy Volunteers Unknown status NCT02587442 Phase 1 RadProtect®
3 A Phase 1b, Single-Dose, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HemaMax™ (rHuIL-12) in Healthy Subjects Completed NCT01742221 Phase 1 Placebo
4 A Dose Blocked-Randomized, Single-Blind, Placebo-Controlled and Dose-Escalation Phase I Clinical Trial to Evaluate Safety, Tolerability and Pharmacokinetic/Pharmacodynamic Characteristics of KMRC011 After Intramuscular Administration in Healthy Adult Volunteers Completed NCT03585803 Phase 1 KMRC011 5μg or Placebo;KMRC011 10μg or Placebo;KMRC011 15μg or Placebo;KMRC011 20μg or Placebo;KMRC011 25μg or Placebo
5 Phase I Study of Eltrombopag for Promoting Thrombopoiesis in Patients Undergoing Stem Cell Transplantation After Total Body Irradiation Completed NCT00903929 Phase 1 Eltrombopag
6 A Dose Escalation Trial Evaluating the Safety and Pharmacokinetic Profiles of BIO 300 Capsules in Healthy Male and Female Volunteers Completed NCT00504335 Phase 1 BIO 300 Capsules
7 A Phase 1 Dose Escalation Trial Evaluating the Safety and Pharmacokinetic Profile of BIO 300 Oral Powder in Healthy Volunteers Recruiting NCT04650555 Phase 1 BIO 300 Oral Powder
8 Open-label Phase I Study to Evaluate the Safety of PLX-R18 for the Post-Exposure Prevention (PEP) or Treatment of Hematopoietic Syndrome of Acute Radiation Syndrome (HS-ARS) Not yet recruiting NCT03797040 Phase 1

Search NIH Clinical Center for Acute Radiation Syndrome

Genetic Tests for Acute Radiation Syndrome

Anatomical Context for Acute Radiation Syndrome

MalaCards organs/tissues related to Acute Radiation Syndrome:

40
Bone Marrow, Spleen, Small Intestine, Myeloid, Skin, Thymus, Cortex

Publications for Acute Radiation Syndrome

Articles related to Acute Radiation Syndrome:

(show top 50) (show all 1247)
# Title Authors PMID Year
1
Software Tools for the Evaluation of Clinical Signs and Symptoms in the Medical Management of Acute Radiation Syndrome-A Five-year Experience. 61
33315652 2021
2
Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome. 61
33692493 2021
3
Author Correction: Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome. 61
33758302 2021
4
Allogeneic adipose-derived stem cells mitigate acute radiation syndrome by the rescue of damaged bone marrow cells from apoptosis. 61
33724714 2021
5
Transfusion of γ-irradiated blood components to individuals does not compromise the cytogenetic dose assessment. 61
33678244 2021
6
Total body irradiation causes a chronic decrease in antioxidant levels. 61
33762608 2021
7
Anti-Ceramide Single-chain Variable Fragment Mitigates Radiation GI Syndrome Mortality Independent of DNA Repair. 61
33724956 2021
8
Sargramostim (rhu GM-CSF) Improves Survival of Non-Human Primates with Severe Bone Marrow Suppression after Acute, High-Dose, Whole-Body Irradiation. 61
33302291 2021
9
Mental health consequences for survivors of the 2011 Fukushima nuclear disaster: a systematic review. Part 2: emotional and behavioral consequences. 61
32189603 2021
10
Optimizing and Profiling Prostaglandin E2 as a Medical Countermeasure for the Hematopoietic Acute Radiation Syndrome. 61
33302300 2021
11
What are the practical, ethical, and pathobiological considerations in the use of minipigs as an animal model in drug discovery for acute radiation syndrome and delayed effects of acute radiation exposure? 61
32892657 2021
12
Establishing Pediatric Mouse Models of the Hematopoietic Acute Radiation Syndrome and the Delayed Effects of Acute Radiation Exposure. 61
33577641 2021
13
Identifying a Diagnostic Window for the Use of Gene Expression Profiling to Predict Acute Radiation Syndrome. 61
33181834 2021
14
Co-Therapy of Pegylated G-CSF and Ghrelin for Enhancing Survival After Exposure to Lethal Radiation. 61
33603673 2021
15
Hematopoietic protection and mechanisms of ferrostatin-1 on hematopoietic acute radiation syndrome of mice. 61
33464146 2021
16
Entolimod as a radiation countermeasure for acute radiation syndrome. 61
33065293 2021
17
Acute radiation syndrome-related gene expression in irradiated peripheral blood cell populations. 61
33476246 2021
18
Tackling the acute radiation syndrome: Hemoperfusion with activated carbon revisited. 61
33279325 2021
19
Commonalities Between COVID-19 and Radiation Injury. 61
33064832 2021
20
Development of hematopoietic syndrome mice model for localized radiation exposure. 61
33420217 2021
21
Radiation-induced gastrointestinal syndrome is exacerbated in vitamin C-insufficient SMP30/GNL knockout mice. 61
32755744 2021
22
Host antibacterial defense of 6-10 Gy γ-irradiated mice subjected to lentiviral vector-based Gas5 gene therapy. 61
33262512 2020
23
Health care for deep space explorers. 61
32734760 2020
24
Proteomic Evaluation of the Natural History of the Acute Radiation Syndrome of the Gastrointestinal Tract in a Non-human Primate Model of Partial-body Irradiation with Minimal Bone Marrow Sparing Includes Dysregulation of the Retinoid Pathway. 61
32947489 2020
25
A Systematic Review of the Hematopoietic Acute Radiation Syndrome (H-ARS) in Canines and Non-human Primates: Acute Mixed Neutron/Gamma vs. Reference Quality Radiations. 61
32947486 2020
26
Evaluation of Plasma Biomarker Utility for the Gastrointestinal Acute Radiation Syndrome in Non-human Primates after Partial Body Irradiation with Minimal Bone Marrow Sparing through Correlation with Tissue and Histological Analyses. 61
32947487 2020
27
Comparative proteomic analysis of serum from nonhuman primates administered BIO 300: a promising radiation countermeasure. 61
33168863 2020
28
Acute Radiation-induced Lung Injury in the Non-human Primate: A Review and Comparison of Mortality and Co-morbidities Using Models of Partial-body Irradiation with Marginal Bone Marrow Sparing and Whole Thorax Lung Irradiation. 61
33009295 2020
29
Development of a Model of the Acute and Delayed Effects of High Dose Radiation Exposure in Jackson Diversity Outbred Mice; Comparison to Inbred C57BL/6 Mice. 61
32932286 2020
30
A Potential Role for Excess Tissue Iron in Development of Cardiovascular Delayed Effects of Acute Radiation Exposure. 61
32868705 2020
31
Immune Reconstitution and Thymic Involution in the Acute and Delayed Hematopoietic Radiation Syndromes. 61
32947490 2020
32
Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. 61
33122357 2020
33
Assessment of the potential impact of embedded radioactive fragments following the use of a crude radiological dispersal device ('dirty bomb'). 61
33124602 2020
34
Radioprotection and Radiomitigation: From the Bench to Clinical Practice. 61
33142986 2020
35
A New Zealand White rabbit model of thrombocytopenia and coagulopathy following total body irradiation across the dose range to induce the hematopoietic-subsyndrome of acute radiation syndrome. 61
31526203 2020
36
Characterization of the hemorrhagic syndrome in the New Zealand white rabbit model following total body irradiation. 61
32909880 2020
37
The New Zealand white rabbit animal model of acute radiation syndrome: hematopoietic and coagulation-based parameters by radiation dose following supportive care. 61
32909860 2020
38
Developing and comparing models of hematopoietic-acute radiation syndrome in Göttingen and Sinclair minipigs. 61
32909874 2020
39
Efficacy of delayed administration of sargramostim up to 120 hours post exposure in a nonhuman primate total body radiation model. 61
32960660 2020
40
Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain-dependent Manner in Mice. 61
32175929 2020
41
Use of MSCs and MSC-educated macrophages to mitigate hematopoietic acute radiation syndrome. 61
32944493 2020
42
Non-Human Primates Receiving High-Dose Total-Body Irradiation are at Risk of Developing Cerebrovascular Injury Years Postirradiation. 61
32942304 2020
43
The impact of supportive care on survival in large animal models of total body irradiation. 61
32909856 2020
44
Use of CT simulation and 3-D radiation therapy treatment planning system to develop and validate a total-body irradiation technique for the New Zealand White rabbit. 61
32924716 2020
45
Using biodosimetry to enhance the public health response to a nuclear incident. 61
32909884 2020
46
Acute Radiation-induced GI-ARS and H-ARS in a Canine Model of Mixed Neutron/Gamma Relative to Reference Co-60 Gamma Radiation: A Retrospective Study. 61
31934930 2020
47
Epitaxially Strained CeO2 /Mn3 O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection. 61
32520432 2020
48
Extracellular vesicles derived from mesenchymal stromal cells mitigate intestinal toxicity in a mouse model of acute radiation syndrome. 61
32854778 2020
49
Mitigative efficacy of the clinical dosage administration of granulocyte colony-stimulating factor and romiplostim in mice with severe acute radiation syndrome. 61
32746943 2020
50
Xenogeneic transplantation of human WJ-MSCs rescues mice from acute radiation syndrome via Nrf-2-dependent regeneration of damaged tissues. 61
32040239 2020

Variations for Acute Radiation Syndrome

Expression for Acute Radiation Syndrome

Search GEO for disease gene expression data for Acute Radiation Syndrome.

Pathways for Acute Radiation Syndrome

GO Terms for Acute Radiation Syndrome

Biological processes related to Acute Radiation Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.16 EPO CSF3
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.96 EPO CSF3
3 negative regulation of neuron death GO:1901215 8.62 EPO CSF3

Molecular functions related to Acute Radiation Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.62 EPO CSF3

Sources for Acute Radiation Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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