MCID: ACT228
MIFTS: 29

Acute Radiation Syndrome

Categories: Rare diseases

Aliases & Classifications for Acute Radiation Syndrome

MalaCards integrated aliases for Acute Radiation Syndrome:

Name: Acute Radiation Syndrome 58
Acute Radiation Sickness 58

Characteristics:

Orphanet epidemiological data:

58
acute radiation syndrome
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

ICD10 via Orphanet 33 T66
Orphanet 58 ORPHA454831

Summaries for Acute Radiation Syndrome

MalaCards based summary : Acute Radiation Syndrome, also known as acute radiation sickness, is related to neutropenia and pancytopenia. An important gene associated with Acute Radiation Syndrome is CSF3 (Colony Stimulating Factor 3), and among its related pathways/superpathways are PI3K-Akt signaling pathway and JAK-STAT signaling pathway. The drugs Interleukin-12 and Amifostine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and liver.

Wikipedia : 74 Acute radiation syndrome (ARS), also known as radiation sickness or radiation poisoning, is a collection... more...

Related Diseases for Acute Radiation Syndrome

Diseases related to Acute Radiation Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 neutropenia 29.9 EPO CSF3
2 pancytopenia 29.4 EPO CSF3
3 blood coagulation disease 29.4 EPO CSF3
4 thrombocytopenia 29.1 EPO CSF3
5 myelodysplastic syndrome 28.6 EPO CSF3
6 leukemia, acute myeloid 28.3 EPO CSF3
7 cataract 10.2
8 dystonia 10.0
9 lymphopenia 9.9
10 macular degeneration, age-related, 1 9.9
11 disseminated intravascular coagulation 9.9
12 bronchopneumonia 9.9
13 amenorrhea 9.9
14 hypothyroidism 9.9
15 candidiasis 9.9
16 tularemia 9.9
17 skin atrophy 9.9
18 syphilis 9.9
19 brain edema 9.9
20 thyroid gland disease 9.9
21 pneumonia 9.9
22 anthrax disease 9.9
23 gastrointestinal system disease 9.9
24 myocarditis 9.9
25 retinitis pigmentosa and erythrocytic microcytosis 9.8 EPO CSF3
26 refractory anemia 9.8 EPO CSF3
27 miliary tuberculosis 9.8 EPO CSF3
28 poems syndrome 9.8 EPO CSF3
29 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 9.7 EPO CSF3
30 hypersplenism 9.7 EPO CSF3
31 hemoglobinuria 9.7 EPO CSF3
32 pulmonary edema 9.7 EPO CSF3
33 sickle cell anemia 9.7 EPO CSF3
34 thrombocytosis 9.7 EPO CSF3
35 blood platelet disease 9.7 EPO CSF3
36 bone marrow cancer 9.7 EPO CSF3
37 polycythemia vera 9.7 EPO CSF3
38 essential thrombocythemia 9.7 EPO CSF3
39 myeloproliferative neoplasm 9.7 EPO CSF3
40 dyskeratosis congenita 9.7 EPO CSF3
41 ataxia-telangiectasia 9.7
42 citrullinemia, classic 9.7
43 pigmentation disease 9.7
44 telangiectasis 9.7
45 diarrhea 9.7
46 duodenal ulcer 9.7
47 viral hepatitis 9.7
48 skin carcinoma 9.7
49 systemic scleroderma 9.7
50 intestinal obstruction 9.7

Graphical network of the top 20 diseases related to Acute Radiation Syndrome:



Diseases related to Acute Radiation Syndrome

Symptoms & Phenotypes for Acute Radiation Syndrome

Drugs & Therapeutics for Acute Radiation Syndrome

Drugs for Acute Radiation Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin-12 Phase 2
2
Amifostine Approved, Investigational Phase 1 20537-88-6 2141
3
Iron Approved, Experimental Phase 1 15438-31-0, 7439-89-6 27284 23925
4 Chelating Agents Phase 1
5 Protective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Single-Dose, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HemaMax™ (rHuIL-12) in Healthy Subjects Completed NCT02343133 Phase 2 Placebo
2 A Phase I Study to Evaluate the Safety and Pharmacokinetics of RadProtect® in Healthy Volunteers Unknown status NCT02587442 Phase 1 RadProtect®
3 A Dose Blocked-Randomized, Single-Blind, Placebo-Controlled and Dose-Escalation Phase I Clinical Trial to Evaluate Safety, Tolerability and Pharmacokinetic/Pharmacodynamic Characteristics of KMRC011 After Intramuscular Administration in Healthy Adult Volunteers Unknown status NCT03585803 Phase 1 KMRC011 5μg or Placebo;KMRC011 10μg or Placebo;KMRC011 20μg or Placebo;KMRC011 30μg or Placebo;KMRC011 45μg or Placebo;KMRC011 60μg or Placebo;KMRC011 75μg or Placebo
4 A Phase 1b, Single-Dose, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HemaMax™ (rHuIL-12) in Healthy Subjects Completed NCT01742221 Phase 1 Placebo
5 A Dose Escalation Trial Evaluating the Safety and Pharmacokinetic Profiles of BIO 300 Capsules in Healthy Male and Female Volunteers Completed NCT00504335 Phase 1 BIO 300 Capsules
6 Phase I Study of Eltrombopag for Promoting Thrombopoiesis in Patients Undergoing Stem Cell Transplantation After Total Body Irradiation Completed NCT00903929 Phase 1 Eltrombopag
7 Open-label Phase I Study to Evaluate the Safety of PLX-R18 for the Post-Exposure Prevention (PEP) or Treatment of Hematopoietic Syndrome of Acute Radiation Syndrome (HS-ARS) Not yet recruiting NCT03797040 Phase 1
8 Validation of Radio-induced Damage Biomarkers : BIOM-DRI Study Recruiting NCT02999152
9 Parental Irradiation of Ukrainian Cleanup Workers and Evacuees and Germline Mutations in Their Offspring (Trio Study) Recruiting NCT02566161

Search NIH Clinical Center for Acute Radiation Syndrome

Genetic Tests for Acute Radiation Syndrome

Anatomical Context for Acute Radiation Syndrome

MalaCards organs/tissues related to Acute Radiation Syndrome:

40
Bone, Bone Marrow, Liver, Small Intestine, Skin, Spleen, Brain

Publications for Acute Radiation Syndrome

Articles related to Acute Radiation Syndrome:

(show top 50) (show all 1191)
# Title Authors PMID Year
1
A New Smartphone Application to Predict Hematologic Acute Radiation Syndrome Based on Blood Cell Count Changes-The H-module App. 61
32484636 2020
2
The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage. 61
31897489 2020
3
Detection of Embedded Low-level Radioactive Shrapnel after the Explosion of a Radiological Dispersal Device in Radiological Emergency Imaging. 61
31913860 2020
4
Epitaxially Strained CeO2 /Mn3 O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection. 61
32520432 2020
5
A Systematic Review of Metabolomic and Lipidomic Candidates for Biomarkers in Radiation Injury. 61
32575772 2020
6
Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril. 61
32486174 2020
7
Gut microbiota-derived indole 3-propionic acid protects against radiation toxicity via retaining acyl-CoA-binding protein. 61
32434586 2020
8
BIO 300: a promising radiation countermeasure under advanced development for acute radiation syndrome and the delayed effects of acute radiation exposure. 61
32450051 2020
9
Alterations in Tissue Metabolite Profiles with Amifostine-Prophylaxed Mice Exposed to Gamma Radiation. 61
32455594 2020
10
Developing polyphenolic acetates as radiation countermeasure agents: current status and future perspectives. 61
32062010 2020
11
Delayed effects of acute whole body lethal radiation exposure in mice pre-treated with BBT-059. 61
32321983 2020
12
Deposition of Iron in the Bone Marrow of a Murine Model of Hematopoietic Acute Radiation Syndrome. 61
32240658 2020
13
Nrf2 played an important role in radiation protection effect of low-level laser exposed on umbilical cord mesenchymal stem cell. 61
32223956 2020
14
Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain- Dependent Manner in Mice. 61
32175929 2020
15
Mental health consequences for survivors of the 2011 Fukushima nuclear disaster: a systematic review. Part 2: emotional and behavioral consequences. 61
32189603 2020
16
Glycyrrhizin Protects γ-Irradiated Mice from Gut Bacteria-Associated Infectious Complications by Improving miR-222-Associated Gas5 RNA Reduction in Macrophages of the Bacterial Translocation Site. 61
31941655 2020
17
Xenogeneic transplantation of human WJ-MSCs rescues mice from acute radiation syndrome via Nrf-2-dependent regeneration of damaged tissues. 61
32040239 2020
18
CDX-301: a novel medical countermeasure for hematopoietic acute radiation syndrome in mice. 61
32019942 2020
19
Prediction of Survival Benefit of Filgrastim in Adult and Pediatric Patients With Acute Radiation Syndrome. 61
32112517 2020
20
Characterization of a partial-body irradiation model with oral cavity shielding in nonhuman primates. 61
29447591 2020
21
Pharmacodynamics of romiplostim alone and in combination with pegfilgrastim on acute radiation-induced thrombocytopenia and neutropenia in non-human primates. 61
31216213 2020
22
Morphological and functional impairment in the gut in a partial body irradiation minipig model of GI-ARS. 61
30475652 2020
23
Romiplostim (Nplate®) as an effective radiation countermeasure to improve survival and platelet recovery in mice. 61
31021662 2020
24
Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma. 61
32426105 2020
25
Radiation mitigation of the intestinal acute radiation injury in mice by 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine. 61
31464098 2020
26
Renoprotective Effects of a New Free Radical Scavenger, XH-003, against Cisplatin-Induced Nephrotoxicity. 61
32377314 2020
27
Informing CONOPS and medical countermeasure deployment strategies after an improvised nuclear device detonation: the importance of delayed treatment efficacy data. 61
30403905 2020
28
WAG/RijCmcr rat models for injuries to multiple organs by single high dose ionizing radiation: similarities to nonhuman primates (NHP). 61
30575429 2020
29
Acute Radiation-induced GI-ARS and H-ARS in a Canine Model of Mixed Neutron/GAMMA Relative to Reference Co-60 GAMMA Radiation: A Retrospective Study. 61
31934930 2020
30
CONTRIBUTION OF BIODOSIMETRY TO DIFFERENT MEDICAL ISSUES. 61
30576526 2019
31
CLINICAL TYPES OF CATARACTS IN A LONG-TERM PERIOD AFTER ACUTE RADIATION SICKNESS. 61
31841490 2019
32
Mitigating Effects of 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) on Hematopoietic Acute Radiation Syndrome after Total-Body Ionizing Irradiation in Mice. 61
31556847 2019
33
RADIATION DOSE IS OF LIMITED CLINICAL USEFULNESS IN PERSONS WITH ACUTE RADIATION SYNDROME. 61
31330030 2019
34
Promising role of filgrastim and α-tocopherol succinate in amelioration of gastrointestinal acute radiation syndrome (GI-ARS) in mice. 61
31350581 2019
35
1,4-Dithiothreitol treatment ameliorates hematopoietic and intestinal injury in irradiated mice: Potential application of a treatment for acute radiation syndrome. 61
31627170 2019
36
The efficacy and safety of amifostine for the acute radiation syndrome. 61
31526195 2019
37
Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome. 61
31698831 2019
38
Macrophages Educated with Exosomes from Primed Mesenchymal Stem Cells Treat Acute Radiation Syndrome by Promoting Hematopoietic Recovery. 61
31394269 2019
39
Remembering Hiroshima and Nagasaki through art. 61
31864452 2019
40
Disasters Resulting from Radiologic and Nuclear Events. 61
31445609 2019
41
Mitigation of radiation-induced gastro-intestinal injury by the polyphenolic acetate 7, 8-diacetoxy-4-methylthiocoumarin in mice. 61
31575959 2019
42
A quantitative comparison of the chemo- and radiotoxicity of uranium at different enrichment grades. 61
31276769 2019
43
A New Zealand White Rabbit Model of Thrombocytopenia and Coagulopathy Following Total Body Irradiation Across the Dose Range to Induce the Hematopoietic-Subsyndrome of Acute Radiation Syndrome. 61
31526203 2019
44
A peptide from Testudo horsfieldii tortoise spleen as a potential helper for reducing acute radiation syndrome. 61
31313444 2019
45
Cancers after Chornobyl: From Epidemiology to Molecular Quantification. 61
31480731 2019
46
Rapid High-Throughput Diagnostic Triage after a Mass Radiation Exposure Event Using Early Gene Expression Changes. 61
31211643 2019
47
Use of Growth Factors and Other Cytokines for Treatment of Injuries During a Radiation Public Health Emergency. 61
31081742 2019
48
Radioprotective effect of newly synthesized toll-like receptor 5 agonist, KMRC011, in mice exposed to total-body irradiation. 61
31165150 2019
49
Use of Growth Factors and Cytokines to Treat Injuries Resulting from a Radiation Public Health Emergency. 61
31063041 2019
50
Drug discovery strategies for acute radiation syndrome. 61
31008662 2019

Variations for Acute Radiation Syndrome

Expression for Acute Radiation Syndrome

Search GEO for disease gene expression data for Acute Radiation Syndrome.

Pathways for Acute Radiation Syndrome

Pathways related to Acute Radiation Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.16 EPO CSF3
2
Show member pathways
11.65 EPO CSF3
3 11.22 EPO CSF3
4 10.95 EPO CSF3
5 10.3 EPO CSF3

GO Terms for Acute Radiation Syndrome

Biological processes related to Acute Radiation Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.16 EPO CSF3
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.96 EPO CSF3
3 negative regulation of neuron death GO:1901215 8.62 EPO CSF3

Molecular functions related to Acute Radiation Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.62 EPO CSF3

Sources for Acute Radiation Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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