MCID: ACT210
MIFTS: 61

Acute Respiratory Distress Syndrome

Categories: Rare diseases, Respiratory diseases, Cardiovascular diseases

Aliases & Classifications for Acute Respiratory Distress Syndrome

MalaCards integrated aliases for Acute Respiratory Distress Syndrome:

Name: Acute Respiratory Distress Syndrome 53
Respiratory Distress Syndrome, Adult 53 73
Non-Cardiogenic Pulmonary Edema 53 73
Acute Respiratory Distress 55 73
Acute Lung Injury 53 59
Increased-Permeability Pulmonary Edema 53
Adult Respiratory Distress Syndrome 53
Shock Lung 53
Stiff Lung 53
Ards 53
Ali 53

Characteristics:

Orphanet epidemiological data:

59
acute lung injury
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 59  
Rare respiratory diseases


External Ids:

Orphanet 59 ORPHA178320
MESH via Orphanet 45 D055371
UMLS via Orphanet 74 C0242488

Summaries for Acute Respiratory Distress Syndrome

NIH Rare Diseases : 53 Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood.  People who develop ARDS often are very ill with another disease or have major injuries. The condition leads to a buildup of fluid in the air sacs which prevents enough oxygen from passing into the bloodstream. Symptoms may include difficulty breathing, low blood pressure and organ failure, rapid breathing and shortness of breath.

MalaCards based summary : Acute Respiratory Distress Syndrome, also known as respiratory distress syndrome, adult, is related to respiratory distress syndrome in premature infants and staphylococcal toxic shock syndrome, and has symptoms including apnea, cheyne-stokes respiration and coughing. An important gene associated with Acute Respiratory Distress Syndrome is LTA (Lymphotoxin Alpha), and among its related pathways/superpathways are PAK Pathway and Toll-like Receptor Signaling Pathway. The drugs Curosurf and Infasurf have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and cervix, and related phenotypes are mortality/aging and respiratory system

Wikipedia : 76 Acute respiratory distress syndrome (ARDS) is a medical condition occurring in critically ill or... more...

Related Diseases for Acute Respiratory Distress Syndrome

Diseases in the Adult Respiratory Distress Syndrome family:

Acute Respiratory Distress Syndrome Adult Acute Respiratory Distress Syndrome

Diseases related to Acute Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 353)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome in premature infants 32.6 SFTPB SFTPC
2 staphylococcal toxic shock syndrome 32.5 IL1B TNF
3 bronchopulmonary dysplasia 32.4 CXCL8 ELANE SFTPB
4 peritonitis 31.7 CXCL8 IL1B IL6 TNF
5 adult respiratory distress syndrome 31.2 CXCL8 ELANE IL6 SFTPB SFTPC TNF
6 pulmonary edema 31.0 CXCL8 IL1B TNF
7 pustular psoriasis 30.8 ELANE PI3 TNF
8 bronchiolitis obliterans 30.7 CXCL8 IL6 TNF
9 bronchiolitis 30.7 CXCL8 IL6 TNF
10 esophagitis 30.5 CXCL8 IL1B IL6
11 burns 30.5 IL1B TNF
12 adult-onset still's disease 30.4 IL1B IL6 TNF
13 acute pancreatitis 30.4 CXCL8 ELANE IL6
14 cytomegalovirus infection 30.4 CXCL8 IL6 TNF
15 bronchitis 30.4 CXCL8 ELANE TNF
16 brucellosis 30.4 CXCL8 IL6 TNF
17 dengue hemorrhagic fever 30.4 CXCL8 IL6 TNF
18 sleep apnea 30.3 CXCL8 IL6 TNF
19 surfactant dysfunction 30.3 SFTPB SFTPC
20 dengue shock syndrome 30.2 IL1B IL6 TNF
21 leptospirosis 30.0 CXCL8 IL1B IL6 TNF
22 wegener granulomatosis 30.0 CXCL8 ELANE IL6 TNF
23 meningitis 29.8 CXCL8 IL1B IL6 TNF
24 malaria 29.8 CXCL8 IL1B IL6 LTA TNF
25 pulmonary hypertension 29.6 ELANE HBG2 IL6 SFTPC
26 arthritis 29.4 CXCL8 IL1B IL6 LTA TNF
27 avian influenza 29.2 CXCL8 IL6 SFTPD TNF
28 psoriasis 28.8 CXCL8 IL1B IL6 LTA PI3 TNF
29 pulmonary fibrosis 28.7 IL1B SFTPC SFTPD
30 pulmonary disease, chronic obstructive 28.3 CXCL8 ELANE IL6 SFTPB SFTPD TNF
31 respiratory failure 27.8 CXCL8 ELANE SFTPB SFTPC SFTPD TNF
32 pneumonia 27.5 CXCL8 ELANE IL1B IL6 SFTPB SFTPC
33 pulmonary fibrosis, idiopathic 27.0 CXCL8 ELANE IL1B SFTPB SFTPC SFTPD
34 interstitial lung disease 26.9 CXCL8 IL1B IL6 SFTPB SFTPC SFTPD
35 lung disease 26.3 CXCL8 ELANE IL1B PI3 SFTPB SFTPC
36 adult acute respiratory distress syndrome 12.3
37 aicardi-goutieres syndrome 1 10.9
38 fructose intolerance, hereditary 10.9
39 al amyloidosis 10.9
40 scorpion envenomation 10.8 IL6 TNF
41 acute transverse myelitis 10.8 CXCL8 IL6
42 leukomalacia 10.8 IL6 TNF
43 tungiasis 10.8 CXCL8 TNF
44 angioimmunoblastic lymphadenopathy with dysproteinemia 10.8 IL6 TNF
45 felty syndrome 10.8 CXCL8 ELANE
46 denture stomatitis 10.8 CXCL8 IL6
47 papillary conjunctivitis 10.8 CXCL8 IL6
48 critical limb ischemia 10.8 IL6 TNF
49 engraftment syndrome 10.7 CXCL8 PI3
50 pasteurellosis 10.7 ELANE PI3

Graphical network of the top 20 diseases related to Acute Respiratory Distress Syndrome:



Diseases related to Acute Respiratory Distress Syndrome

Symptoms & Phenotypes for Acute Respiratory Distress Syndrome

UMLS symptoms related to Acute Respiratory Distress Syndrome:


apnea, cheyne-stokes respiration, coughing, dyspnea, hemoptysis, hoarseness, respiratory distress, labored breathing

MGI Mouse Phenotypes related to Acute Respiratory Distress Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.65 F5 IL1B IL6 LTA PLA2G7 SFTPB
2 respiratory system MP:0005388 9.1 IL6 LTA SFTPB SFTPC SFTPD TNF

Drugs & Therapeutics for Acute Respiratory Distress Syndrome

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Curosurf 18 PORACTANT ALFA Dey Laboratories October 1998
2
Infasurf 18 CALFACTANT ONY July 1998

Drugs for Acute Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 485)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6 23994
2
Menthol Approved Phase 4,Phase 3,Phase 2,Not Applicable 2216-51-5 16666
3
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
4
Metformin Approved Phase 4,Phase 2,Phase 3,Not Applicable 657-24-9 14219 4091
5
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-23-7 5754
6
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 9005-49-6 772 46507594
7
Clonidine Approved Phase 4 4205-90-7 2803
8
Budesonide Approved Phase 4,Phase 2,Not Applicable 51333-22-3 63006 5281004
9
Atracurium Approved, Experimental, Investigational Phase 4,Not Applicable 64228-79-1 47319
10
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
11
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 57-83-0 5994
12
Ketamine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 6740-88-1 3821
13
Atropine Approved, Vet_approved Phase 4,Not Applicable 5908-99-6, 51-55-8 174174
14
Midazolam Approved, Illicit Phase 4,Phase 3,Not Applicable 59467-70-8 4192
15
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
16
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
17
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
18
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
19
Cisatracurium Approved Phase 4,Phase 3 96946-41-7
20
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
21
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 378-44-9 9782
22
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
23
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
24
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
25
Thrombin Approved, Investigational Phase 4
26
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
27 Beractant Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 108778-82-1
28
Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
29 Poractant alfa Approved Phase 4,Phase 2,Phase 3,Not Applicable 129069-19-8
30
Racepinephrine Approved Phase 4,Phase 3,Phase 2 329-65-7 838
31
Carbon monoxide Approved, Investigational Phase 4,Phase 1 630-08-0 281
32 Nefopam Approved, Investigational Phase 4 13669-70-0
33
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
34
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 57-27-2 5288826
35
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
36
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-02-2 5743
37
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 113775-47-6 68602 5311068
38
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
39
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
40
Labetalol Approved Phase 4 36894-69-6 3869
41
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
42
Nifedipine Approved Phase 4,Phase 3 21829-25-4 4485
43
Metronidazole Approved Phase 4,Phase 2,Phase 3,Not Applicable 443-48-1 4173
44
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
45
Misoprostol Approved Phase 4,Not Applicable 59122-46-2 5282381
46
Serine Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 56-45-1 5951
47 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
49
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 77-92-9 311
50
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 56-40-6 750

Interventional clinical trials:

(show top 50) (show all 1244)
# Name Status NCT ID Phase Drugs
1 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
2 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
3 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4 propofol
4 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
5 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
6 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
7 Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
8 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
9 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
10 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
11 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
12 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
13 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
14 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
15 Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel) Unknown status NCT01230931 Phase 4
16 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
17 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
18 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
19 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
20 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
21 Corticosteroid Mediates Acute Respiratory Distress Syndrome Completed NCT02819453 Phase 4 Methylprednisolone
22 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
23 Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study) Completed NCT02166853 Phase 4 sevoflurane;midazolam
24 Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome Completed NCT00391105 Phase 4 Remifentanil
25 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
26 Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide Completed NCT01923844 Phase 4 exogenous surfactant
27 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Completed NCT01042600 Phase 4
28 Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
29 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
30 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
31 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
32 Laryngoscope Versus CMAC for Endotracheal Intubation in Patients Undergoing Emergent Airway Management Completed NCT01710891 Phase 4
33 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
34 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
35 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
36 On Versus Off Pump Myocardial Revascularization Study Completed NCT01290952 Phase 4
37 Inflammatory Response Secondary Using Intravenous Anesthesia Versus Inhalation Anesthesia With Halogenated Agents Completed NCT02168751 Phase 4 propofol;Sevoflurane
38 Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation Completed NCT02962999 Phase 4 Ketamine;Saline
39 Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix Completed NCT02338830 Phase 4 Progesterone
40 Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With AECOPD Completed NCT03333395 Phase 4 Nebulized heparin and salbutamol;Nebulized salbutamol
41 A Randomized Trial Comparing the Impact of One Versus Two Courses of Antenatal Steroids (ACS) on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
42 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
43 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
44 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
45 Long Protocol and Freeze All Embryos vs Antagonist Protocol With Fresh Embryo Transfer in PCOS Patients Undergoing ICSI Completed NCT03118830 Phase 4 Triptorelin;cetrorelix;Recombinant Follicle Stimulating Hormone
46 Recruitment Maneuver After Intubation Completed NCT01014299 Phase 4
47 Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study) Completed NCT01282996 Phase 4
48 Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) Completed NCT02253082 Phase 4 OctaplasLG®
49 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
50 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4

Search NIH Clinical Center for Acute Respiratory Distress Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Acute Respiratory Distress Syndrome

Anatomical Context for Acute Respiratory Distress Syndrome

MalaCards organs/tissues related to Acute Respiratory Distress Syndrome:

41
Lung, Brain, Cervix, Liver, Heart, Testes, Fetal Lung

Publications for Acute Respiratory Distress Syndrome

Articles related to Acute Respiratory Distress Syndrome:

(show top 50) (show all 576)
# Title Authors Year
1
Heart-lung interactions in acute respiratory distress syndrome: pathophysiology, detection and management strategies. ( 29430444 )
2018
2
Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia. ( 29431568 )
2018
3
The relationship between high-dose corticosteroid treatment and mortality in acute respiratory distress syndrome: a retrospective and observational study using a nationwide administrative database in Japan. ( 29415701 )
2018
4
Acute respiratory distress syndrome in a man with Epstein-Barr virus infection-induced hypocomplementemic urticarial vasculitis. ( 29458992 )
2018
5
Naloxone-Induced Non-Cardiogenic Pulmonary Edema: A Case Report. ( 29749582 )
2018
6
The Use of Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome in Severe Burns Without Inhalation Injury. ( 29901798 )
2018
7
Antipsychotics, Delirium, and Acute Respiratory Distress Syndrome: What is the Link? ( 29444340 )
2018
8
A new side effect of synthetic cannabinoid use by the bucket (waterpipe) method: Acute respiratory distress syndrome (ARDS). ( 29942884 )
2018
9
Understanding Macrophages in Acute Respiratory Distress Syndrome: From Pathophysiology to Precision Medicine. ( 29912110 )
2018
10
Alk5/Runx1 signaling mediated by extracellular vesicles promotes vascular repair in acute respiratory distress syndrome. ( 29931538 )
2018
11
NF-I_B-Induced MicroRNA-211 Inhibits Interleukin-10 in Macrophages of Rats with Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. ( 29402831 )
2018
12
Genetic Variation in MAP3K1 Associates with Ventilator-Free Days in Acute Respiratory Distress Syndrome. ( 28858533 )
2018
13
Extracorporeal Membrane Oxygenation in a 39-Year-Old Man with Traumatic Pulmonary Contusions and Acute Respiratory Distress Syndrome. ( 29935697 )
2018
14
Acute respiratory distress syndrome and Plasmodium ovale malaria. ( 29886120 )
2018
15
Low endocan levels are predictive of Acute Respiratory Distress Syndrome in severe sepsis and septic shock. ( 29957509 )
2018
16
Nonpulmonary risk factors of acute respiratory distress syndrome in patients with septic bacteraemia. ( 29898577 )
2018
17
Increased circulating microRNA-122 is associated with mortality and acute liver injury in the acute respiratory distress syndrome. ( 29935532 )
2018
18
miR-155-5p Promotes Progression of Acute Respiratory Distress Syndrome by Inhibiting Differentiation of Bone Marrow Mesenchymal Stem Cells to Alveolar Type II Epithelial Cells. ( 29936517 )
2018
19
Focal Encephalitis, Meningitis and Acute Respiratory Distress Syndrome Associated with Influenza A Infection. ( 29402867 )
2018
20
The Randomized Educational Acute Respiratory Distress Syndrome Diagnosis Study: A Trial to Improve the Radiographic Diagnosis of Acute Respiratory Distress Syndrome. ( 29438110 )
2018
21
Setting PEEP in Pediatric Acute Respiratory Distress Syndrome: Cookbook or Individualized Titration? ( 29958026 )
2018
22
Factors associated with missed assessments in a 2-year longitudinal study of acute respiratory distress syndrome survivors. ( 29907087 )
2018
23
Anticoagulant therapy in acute respiratory distress syndrome. ( 29430453 )
2018
24
Subtypes of pediatric acute respiratory distress syndrome have different predictors of mortality. ( 29971591 )
2018
25
Unilateral Acute Respiratory Distress Syndrome with Contralateral Pulmonary Artery Agenesis. ( 29125306 )
2018
26
Pediatric Acute Respiratory Distress Syndrome - Increase the PEEP? ( 29451804 )
2018
27
Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration. ( 29310581 )
2018
28
The effects of hemoglobin glutamer-200 and iNO on pulmonary vascular tone and arterial oxygenation in an experimental acute respiratory distress syndrome. ( 29425776 )
2018
29
Genome Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor. ( 29425463 )
2018
30
Implementation of preemptive fluid strategy as a bundle to prevent fluid overload in children with acute respiratory distress syndrome and sepsis. ( 29945586 )
2018
31
Distinctive Roles and Mechanisms of Human Neutrophil Peptides in Experimental Sepsis and Acute Respiratory Distress Syndrome. ( 29979223 )
2018
32
Acute respiratory distress syndrome without identifiable risk factors: A secondary analysis of the ARDS network trials. ( 29898428 )
2018
33
Effects of hypercapnia in acute respiratory distress syndrome. ( 29430454 )
2018
34
Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care. ( 29958249 )
2018
35
Severe Plasmodium ovale malaria complicated by acute respiratory distress syndrome in a young Caucasian man. ( 29609605 )
2018
36
An Exploratory Reanalysis of the Randomized Trial on Efficacy of Corticosteroids as Rescue Therapy for the Late Phase of Acute Respiratory Distress Syndrome. ( 29432350 )
2018
37
Is Overall Mortality the Right Composite Endpoint in Clinical Trials of Acute Respiratory Distress Syndrome? ( 29420341 )
2018
38
Pediatric acute respiratory distress syndrome - current views. ( 29434764 )
2018
39
Macrolide therapy is associated with reduced mortality in acute respiratory distress syndrome (ARDS) patients. ( 29430441 )
2018
40
Effect of vitamin D deficiency in Korean patients with acute respiratory distress syndrome. ( 29914229 )
2018
41
Diagnosis of acute respiratory distress syndrome by exhaled breath analysis. ( 29430450 )
2018
42
Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. ( 29895331 )
2018
43
Novel complication of an emerging disease: Invasive<i>Klebsiella pneumoniae</i>liver abscess syndrome as a cause of acute respiratory distress syndrome. ( 29441188 )
2018
44
Gastrointestinal tuberculosis following renal transplantation accompanied with septic shock and acute respiratory distress syndrome: a survival case presentation. ( 29179699 )
2017
45
Noninvasive ventilation during acute respiratory distress syndrome in patients with cancer-what really matters. ( 28932510 )
2017
46
Incidence Proportion of Acute Cor Pulmonale in Patients with Acute Respiratory Distress Syndrome Subjected to Lung Protective Ventilation: A Systematic Review and Meta-analysis. ( 28701843 )
2017
47
Muscle Weakness and 5-Year Survival in Acute Respiratory Distress Syndrome Survivors. ( 28067712 )
2017
48
A Morphological and Quantitative Analysis of Lung CT Scan in Patients With Acute Respiratory Distress Syndrome and in Cardiogenic Pulmonary Edema. ( 29161936 )
2017
49
A Missense Genetic Variant in LRRC16A/CARMIL1 Improves Acute Respiratory Distress Syndrome Survival by Attenuating Platelet Count Decline. ( 27768389 )
2017
50
The Bumpy Road for Noninvasive Ventilation in Acute Respiratory Distress Syndrome. Coming to an End? ( 28035848 )
2017

Variations for Acute Respiratory Distress Syndrome

Expression for Acute Respiratory Distress Syndrome

Search GEO for disease gene expression data for Acute Respiratory Distress Syndrome.

Pathways for Acute Respiratory Distress Syndrome

Pathways related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 CXCL8 IL1B IL6 LTA PLA2G7 TNF
2
Show member pathways
12.93 CXCL8 IL1B IL6 SFTPD TNF
3
Show member pathways
12.8 CXCL8 IL1B IL6 LTA TNF
4
Show member pathways
12.73 CXCL8 IL1B IL6 LTA TNF
5
Show member pathways
12.66 CXCL8 IL1B IL6 TNF
6
Show member pathways
12.61 IL1B IL6 LTA TNF
7
Show member pathways
12.54 CXCL8 IL1B IL6 LTA TNF
8
Show member pathways
12.28 CXCL8 IL1B IL6 TNF
9
Show member pathways
12.22 IL1B IL6 LTA TNF
10
Show member pathways
12.22 CXCL8 IL1B IL6 TNF
11
Show member pathways
12.18 CXCL8 IL1B IL6 TNF
12 12.12 CXCL8 IL1B IL6 TNF
13 11.95 CXCL8 IL1B IL6 TNF
14 11.92 CXCL8 IL1B IL6 TNF
15 11.88 CXCL8 IL1B IL6
16
Show member pathways
11.87 CXCL8 IL1B IL6 SFTPD TNF
17 11.86 IL1B IL6 LTA TNF
18 11.84 IL1B IL6 TNF
19
Show member pathways
11.82 SFTPB SFTPC SFTPD
20 11.81 CXCL8 IL1B IL6 TNF
21 11.78 CXCL8 IL1B IL6 TNF
22 11.77 CXCL8 IL1B IL6
23 11.76 CXCL8 IL1B LTA TNF
24 11.74 IL1B LTA TNF
25 11.7 IL1B IL6 TNF
26 11.69 CXCL8 IL1B IL6 TNF
27 11.59 CXCL8 IL1B IL6 TNF
28 11.49 ELANE IL6 TNF
29
Show member pathways
11.47 CXCL8 IL1B IL6 TNF
30 11.46 IL1B IL6 TNF
31
Show member pathways
11.43 SFTPB SFTPC SFTPD
32 11.36 CXCL8 IL1B IL6 TNF
33 11.33 IL1B IL6 TNF
34 11.32 IL1B IL6 TNF
35 11.27 IL1B IL6 TNF
36 11.25 IL1B IL6 TNF
37 11.23 IL1B IL6 TNF
38 11.15 CXCL8 IL1B IL6 TNF
39
Show member pathways
11.11 SFTPB SFTPC SFTPD
40 11.1 IL1B PLA2G7
41 11.08 CXCL8 TNF
42 11.04 IL1B TNF
43 11.03 IL6 TNF
44 10.95 CXCL8 IL1B IL6 TNF
45 10.91 CXCL8 IL6 TNF
46 10.89 IL1B TNF
47 10.82 CXCL8 IL1B IL6 SFTPC TNF

GO Terms for Acute Respiratory Distress Syndrome

Cellular components related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CXCL8 ELANE F5 IL1B IL6 LTA
2 clathrin-coated endocytic vesicle GO:0045334 9.43 SFTPB SFTPC SFTPD
3 extracellular region GO:0005576 9.4 CXCL8 ELANE F5 IL1B IL6 LTA
4 lamellar body GO:0042599 9.33 SFTPB SFTPC SFTPD
5 multivesicular body lumen GO:0097486 9.32 SFTPB SFTPC

Biological processes related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.96 CXCL8 IL1B IL6 LTA TNF
2 inflammatory response GO:0006954 9.94 CXCL8 IL1B IL6 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.91 CXCL8 IL1B IL6 TNF
4 regulation of signaling receptor activity GO:0010469 9.89 CXCL8 IL1B IL6 LTA TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B IL6 TNF
6 response to lipopolysaccharide GO:0032496 9.83 CXCL8 ELANE IL1B LTA
7 cellular response to lipopolysaccharide GO:0071222 9.82 CXCL8 IL6 TNF
8 positive regulation of DNA binding transcription factor activity GO:0051091 9.8 IL1B IL6 TNF
9 defense response to Gram-positive bacterium GO:0050830 9.79 IL6 LTA TNF
10 humoral immune response GO:0006959 9.74 IL6 LTA TNF
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.72 ELANE IL6 TNF
12 positive regulation of interleukin-6 production GO:0032755 9.69 IL1B IL6 TNF
13 positive regulation of leukocyte chemotaxis GO:0002690 9.66 CXCL8 IL6
14 positive regulation of chemokine production GO:0032722 9.65 IL6 TNF
15 embryonic digestive tract development GO:0048566 9.64 CXCL8 TNF
16 negative regulation of lipid catabolic process GO:0050995 9.63 IL1B TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IL1B TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL1B TNF
19 positive regulation of interferon-gamma production GO:0032729 9.61 IL1B LTA TNF
20 negative regulation of lipid storage GO:0010888 9.6 IL6 TNF
21 positive regulation of chemokine biosynthetic process GO:0045080 9.59 IL1B TNF
22 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.58 ELANE TNF
23 regulation of establishment of endothelial barrier GO:1903140 9.58 IL1B TNF
24 positive regulation of fever generation GO:0031622 9.54 IL1B TNF
25 respiratory gaseous exchange GO:0007585 9.5 SFTPB SFTPC SFTPD
26 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.48 LTA TNF
27 sequestering of triglyceride GO:0030730 9.46 IL1B TNF
28 positive regulation of phagocytosis GO:0050766 9.43 IL1B SFTPD TNF
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IL1B TNF
30 negative regulation of chemokine biosynthetic process GO:0045079 9.37 ELANE IL6
31 cellular protein metabolic process GO:0044267 9.35 F5 IL6 SFTPB SFTPC SFTPD
32 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 LTA TNF
33 negative regulation of growth of symbiont in host GO:0044130 8.8 ELANE LTA TNF

Molecular functions related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL1B IL6 LTA TNF

Sources for Acute Respiratory Distress Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet