ALI
MCID: ACT210
MIFTS: 66

Acute Respiratory Distress Syndrome (ALI)

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Acute Respiratory Distress Syndrome

MalaCards integrated aliases for Acute Respiratory Distress Syndrome:

Name: Acute Respiratory Distress Syndrome 54 17
Acute Lung Injury 54 60 17
Respiratory Distress Syndrome, Adult 54 74
Non-Cardiogenic Pulmonary Edema 54 74
Acute Respiratory Distress 56 74
Increased-Permeability Pulmonary Edema 54
Adult Respiratory Distress Syndrome 54
Shock Lung 54
Stiff Lung 54
Ards 54
Ali 54

Characteristics:

Orphanet epidemiological data:

60
acute lung injury
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 60  
Rare respiratory diseases


External Ids:

MESH via Orphanet 46 D055371
UMLS via Orphanet 75 C0242488
Orphanet 60 ORPHA178320

Summaries for Acute Respiratory Distress Syndrome

NIH Rare Diseases : 54 Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood.  People who develop ARDS often are very ill with another disease or have major injuries. The condition leads to a buildup of fluid in the air sacs which prevents enough oxygen from passing into the bloodstream. Symptoms may include difficulty breathing, low blood pressure and organ failure, rapid breathing and shortness of breath.

MalaCards based summary : Acute Respiratory Distress Syndrome, also known as acute lung injury, is related to respiratory distress syndrome in premature infants and bronchopulmonary dysplasia, and has symptoms including dyspnea, respiratory distress and apnea. An important gene associated with Acute Respiratory Distress Syndrome is LTA (Lymphotoxin Alpha), and among its related pathways/superpathways are PAK Pathway and Toll-like Receptor Signaling Pathway. The drugs Curosurf and Infasurf have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and endothelial, and related phenotypes are immune system and mortality/aging

Wikipedia : 77 Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by rapid onset... more...

Related Diseases for Acute Respiratory Distress Syndrome

Diseases in the Adult Respiratory Distress Syndrome family:

Acute Respiratory Distress Syndrome Adult Acute Respiratory Distress Syndrome

Diseases related to Acute Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 637)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome in premature infants 32.5 SFTPB SFTPC
2 bronchopulmonary dysplasia 32.2 CXCL8 ELANE SFTPB
3 staphylococcal toxic shock syndrome 32.1 IL1B TNF
4 adult respiratory distress syndrome 32.0 CXCL8 ELANE IL6 SFTPB SFTPC TNF
5 peritonitis 31.8 CXCL8 IL1B IL6 TNF
6 burns 31.3 IL1B TNF
7 pulmonary edema 31.0 CXCL8 IL1B TNF
8 pustular psoriasis 30.6 ELANE PI3 TNF
9 acute pancreatitis 30.6 CXCL8 ELANE IL6
10 bronchiolitis 30.6 CXCL8 IL6 TNF
11 leptospirosis 30.5 CXCL8 IL1B IL6 TNF
12 adult-onset still's disease 30.5 IL1B IL6 TNF
13 malaria 30.5 CXCL8 IL1B IL6 LTA TNF
14 bronchiolitis obliterans 30.4 CXCL8 IL6 TNF
15 cardiogenic shock 30.4 IL6 TNF
16 pyelonephritis 30.3 CXCL8 IL1B IL6 TNF
17 cerebral artery occlusion 30.3 IL1B TNF
18 capillary leak syndrome 30.2 CXCL8 ELANE IL6
19 cytomegalovirus infection 30.2 CXCL8 IL1B IL6 TNF
20 pulmonary fibrosis 30.2 IL1B SFTPC SFTPD
21 avian influenza 30.1 CXCL8 IL6 SFTPD TNF
22 hemorrhagic fever with renal syndrome 30.1 CXCL8 IL6 TNF
23 dengue hemorrhagic fever 30.1 CXCL8 IL6 TNF
24 haemophilus influenzae 30.1 CXCL8 IL1B TNF
25 scorpion envenomation 30.1 IL6 TNF
26 crohn's colitis 30.1 CXCL8 IL1B TNF
27 sarcoidosis 1 30.1 IL1B LTA TNF
28 sleep apnea 30.1 CXCL8 IL1B IL6 TNF
29 spinal cord injury 30.1 CXCL8 IL6 TNF
30 endocarditis 30.1 CXCL8 IL6 TNF
31 bronchitis 30.0 CXCL8 ELANE TNF
32 aseptic meningitis 30.0 CXCL8 IL1B TNF
33 aspergillosis 30.0 ELANE SFTPD TNF
34 dengue shock syndrome 30.0 IL1B IL6 TNF
35 q fever 30.0 IL1B IL6 TNF
36 chikungunya 30.0 IL1B IL6 TNF
37 kawasaki disease 30.0 ELANE IL6 TNF
38 lyme disease 30.0 IL1B IL6 TNF
39 arthritis 30.0 CXCL8 IL1B IL6 LTA TNF
40 toxoplasmosis 29.9 IL1B IL6 TNF
41 bacterial sepsis 29.9 CXCL8 ELANE TNF
42 acquired immunodeficiency syndrome 29.9 IL1B IL6 TNF
43 colitis 29.9 CXCL8 IL1B IL6 TNF
44 meningitis 29.8 CXCL8 IL1B IL6 TNF
45 osteomyelitis 29.8 CXCL8 IL1B IL6 TNF
46 chlamydia 29.8 CXCL8 IL1B IL6 TNF
47 ulcerative colitis 29.8 CXCL8 IL1B IL6 TNF
48 graft-versus-host disease 29.7 IL1B IL6 TNF
49 meconium aspiration syndrome 29.7 CXCL8 IL6 SFTPB TNF
50 intracranial hypertension 29.7 F5 IL1B TNF

Graphical network of the top 20 diseases related to Acute Respiratory Distress Syndrome:



Diseases related to Acute Respiratory Distress Syndrome

Symptoms & Phenotypes for Acute Respiratory Distress Syndrome

UMLS symptoms related to Acute Respiratory Distress Syndrome:


dyspnea, respiratory distress, apnea, hemoptysis, cheyne-stokes respiration, coughing, hoarseness, labored breathing

MGI Mouse Phenotypes related to Acute Respiratory Distress Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.76 ELANE IL1B IL6 LTA PLA2G7 SFTPC
2 mortality/aging MP:0010768 9.65 ELANE F5 IL1B IL6 LTA PLA2G7
3 respiratory system MP:0005388 9.1 IL6 LTA SFTPB SFTPC SFTPD TNF

Drugs & Therapeutics for Acute Respiratory Distress Syndrome

FDA approved drugs:

# Drug Name Active Ingredient(s) 19 Company Approval Date
1
Curosurf 19 PORACTANT ALFA Dey Laboratories October 1998
2
Infasurf 19 CALFACTANT ONY July 1998

Drugs for Acute Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 518)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisatracurium Approved Phase 4,Phase 3,Early Phase 1 96946-41-7
2
Remifentanil Approved Phase 4,Not Applicable,Early Phase 1 132875-61-7 60815
3
Midazolam Approved, Illicit Phase 4,Phase 3,Not Applicable 59467-70-8 4192
4
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
5
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
6
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
7
Racepinephrine Approved Phase 4,Phase 3,Phase 2 329-65-7 838
8
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
9
Budesonide Approved Phase 4,Phase 2,Not Applicable 51333-22-3 63006 5281004
10 Beractant Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 108778-82-1
11 Poractant alfa Approved Phase 4,Phase 2,Phase 3,Not Applicable 129069-19-8
12
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 103-90-2 1983
13
Clonidine Approved Phase 4 4205-90-7 2803
14
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
15
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
16
Sufentanil Approved, Investigational Phase 4,Early Phase 1 56030-54-7 41693
17
Nefopam Approved, Investigational Phase 4 13669-70-0
18
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 302-25-0
19
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
20
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
21
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Not Applicable 2921-57-5
22
Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
23
Atracurium Approved, Experimental, Investigational Phase 4,Not Applicable 64228-79-1 47319
24
Metformin Approved Phase 4,Phase 2,Phase 3,Not Applicable 657-24-9 14219 4091
25
Carbon monoxide Approved, Investigational Phase 4,Phase 2,Phase 1 630-08-0 281
26
Atropine Approved, Vet_approved Phase 4,Phase 1,Not Applicable 51-55-8, 5908-99-6 174174
27
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
28
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1401-55-4
29
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
30
Ketamine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 6740-88-1 3821
31
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 57-83-0 5994
32
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 378-44-9 9782
33
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6 32051
34
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1177-87-3
35
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-02-2 5743
36
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 28523-86-6 5206
37
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 57-27-2 5288826
38
Rocuronium Approved Phase 4,Not Applicable,Early Phase 1 119302-91-9, 143558-00-3 441290
39
Succinylcholine Approved Phase 4 306-40-1 5314
40
Cetrorelix Approved, Investigational Phase 4 120287-85-6 25074887 16129715
41
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 113775-47-6 68602 5311068
42
Nifedipine Approved Phase 4,Phase 3,Not Applicable 21829-25-4 4485
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable,Early Phase 1 437-38-7 3345
44
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 68-04-2
45
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
46
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
47
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
48
Metronidazole Approved Phase 4,Phase 2,Phase 3,Not Applicable 443-48-1 4173
49
Labetalol Approved Phase 4 36894-69-6 3869
50
Misoprostol Approved Phase 4,Not Applicable 59122-46-2 5282381

Interventional clinical trials:

(show top 50) (show all 1374)
# Name Status NCT ID Phase Drugs
1 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
2 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
3 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4 propofol
4 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
5 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
6 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
7 Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
8 SLI MANEUVER and RESPIRATORY MORBIDITIES Unknown status NCT02887924 Phase 4
9 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
10 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
11 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
12 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
13 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
14 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
15 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
16 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
17 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
18 Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length Unknown status NCT02746900 Phase 4
19 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
20 Preventing Recurrent Gestational Diabetes With Metformin Unknown status NCT02394158 Phase 4 Metformin;placebo
21 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
22 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
23 Corticosteroid Mediates Acute Respiratory Distress Syndrome Completed NCT02819453 Phase 4 Methylprednisolone
24 Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome Completed NCT01731795 Phase 4 Dexamethasone
25 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
26 Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study) Completed NCT02166853 Phase 4 sevoflurane;midazolam
27 Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome Completed NCT00391105 Phase 4 Remifentanil
28 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
29 Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide Completed NCT01923844 Phase 4 exogenous surfactant
30 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Completed NCT01042600 Phase 4
31 Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
32 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
33 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
34 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
35 Laryngoscope Versus CMAC for Endotracheal Intubation in Patients Undergoing Emergent Airway Management Completed NCT01710891 Phase 4
36 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
37 Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery Completed NCT02635542 Phase 4 Succinylcholine;Cisatracurium
38 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
39 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
40 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
41 On Versus Off Pump Myocardial Revascularization Study Completed NCT01290952 Phase 4
42 Inflammatory Response Secondary Using Intravenous Anesthesia Versus Inhalation Anesthesia With Halogenated Agents Completed NCT02168751 Phase 4 propofol;Sevoflurane
43 Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation Completed NCT02962999 Phase 4 Ketamine;Saline
44 Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix Completed NCT02338830 Phase 4 Progesterone
45 A Randomized Trial Comparing the Impact of One Versus Two Courses of Antenatal Steroids (ACS) on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
46 The Study of Pharmacokinetics and Pharmacodynamics of Cisatracurium Completed NCT03337373 Phase 4 cisatracurium
47 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
48 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
49 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
50 Long Protocol and Freeze All Embryos vs Antagonist Protocol With Fresh Embryo Transfer in PCOS Patients Undergoing ICSI Completed NCT03118830 Phase 4 Triptorelin;cetrorelix;Recombinant Follicle Stimulating Hormone

Search NIH Clinical Center for Acute Respiratory Distress Syndrome

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Acute Respiratory Distress Syndrome

Anatomical Context for Acute Respiratory Distress Syndrome

MalaCards organs/tissues related to Acute Respiratory Distress Syndrome:

42
Lung, Neutrophil, Endothelial, Brain, Liver, Heart, Bone

Publications for Acute Respiratory Distress Syndrome

Articles related to Acute Respiratory Distress Syndrome:

(show top 50) (show all 6427)
# Title Authors Year
1
Misdiagnosis: Acute Chest Syndrome That Evolved into Acute Respiratory Distress Syndrome in a Patient without a Documented History of Hemoglobinopathy. ( 30853992 )
2019
2
Effects of Tec Tyrosine Kinase Inhibition on the Inflammatory Response of Severe Acute Pancreatitis-Associated Acute Lung Injury in Mice. ( 30761473 )
2019
3
Immature granulocytes: A novel biomarker of acute respiratory distress syndrome in patients with acute pancreatitis. ( 30558840 )
2019
4
microRNA-542-5p protects against acute lung injury in mice with severe acute pancreatitis by suppressing the mitogen-activated protein kinase signaling pathway through the negative regulation of P21-activated kinase 1. ( 30216510 )
2019
5
The complex kinetics of blood endocan during the time course of sepsis and acute respiratory distress syndrome. ( 30867004 )
2019
6
Is a Part Better than the Whole for Cell-based Therapy for Acute Respiratory Distress Syndrome? ( 30870157 )
2019
7
Mechanical Ventilation in Acute Respiratory Distress Syndrome: Time Heals All Wounds, or Does It? ( 30870162 )
2019
8
Acute respiratory distress syndrome. ( 30872579 )
2019
9
Acute respiratory distress syndrome. ( 30872586 )
2019
10
Quality of Life and Lung Function in Survivors of Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome. ( 30875355 )
2019
11
Methylprednisolone: Likely an Effective Treatment in Acute Respiratory Distress Syndrome. ( 30882439 )
2019
12
Airway Pressure Release Ventilation as a Rescue for Acute Respiratory Distress Syndrome But Use Early to Prevent It! ( 30882445 )
2019
13
Lung compliance and outcomes in patients with acute respiratory distress syndrome receiving ECMO (Commentary). ( 30890416 )
2019
14
The Worm that Clogs the Lungs: Strongyloides Hyper-Infection Leading to Fatal Acute Respiratory Distress Syndrome (ARDS). ( 30898993 )
2019
15
Nationwide cohort study of independent risk factors for acute respiratory distress syndrome after trauma. ( 30899792 )
2019
16
Effect of transpulmonary pressure-guided positive end-expiratory pressure titration on lung injury in pigs with acute respiratory distress syndrome. ( 30903412 )
2019
17
G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene and lung ultrasound score as prognostic markers in evaluating the outcome of acute respiratory distress syndrome. ( 30906481 )
2019
18
Acute Respiratory Distress Syndrome Associated With Clopidogrel in a Young Male Patient. ( 30906739 )
2019
19
Respiratory Mechanics, Lung Recruitability, and Gas Exchange in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome. ( 30908313 )
2019
20
Activation of death-associated protein kinase 1 promotes neutrophil apoptosis to accelerate inflammatory resolution in acute respiratory distress syndrome. ( 30911150 )
2019
21
Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models. ( 30911932 )
2019
22
Individualizing Sedation in Acute Respiratory Distress Syndrome Patients on Extracorporeal Membrane Oxygenation. ( 30913098 )
2019
23
Individualizing and Minimizing Sedation on Venovenous Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome Patients, a Reply. ( 30913105 )
2019
24
Effect of body position and inclination in supine and prone position on respiratory mechanics in acute respiratory distress syndrome. ( 30535985 )
2019
25
Vascular endothelial growth factor increased the permeability of respiratory barrier in acute respiratory distress syndrome model in mice. ( 30551503 )
2019
26
Mechanism of airway closure in acute respiratory distress syndrome: a possible role of surfactant depletion. ( 30560279 )
2019
27
Pulmonary Thromboses in Pediatric Acute Respiratory Distress Syndrome. ( 30584066 )
2019
28
Hospital Readmission and Subsequent Decline in Long-Term Survivors of Acute Respiratory Distress Syndrome. ( 30600230 )
2019
29
A case of acute respiratory distress syndrome due to lymphography with Lipiodol for chylothorax after esophagectomy. ( 30607654 )
2019
30
First case of acute respiratory distress syndrome and alimentary tract hemorrhage following mass ingestion of methylisothiazolinone. ( 30607988 )
2019
31
Fluid Accumulation and Pediatric Acute Respiratory Distress Syndrome: What Do We Really Know? ( 30614983 )
2019
32
Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome. ( 30622219 )
2019
33
Acute Respiratory Distress Syndrome: Biomarkers, Mechanisms, and Water Channels. ( 30624248 )
2019
34
A Prognostic Enrichment Strategy for Selection of Patients With Acute Respiratory Distress Syndrome in Clinical Trials. ( 30624279 )
2019
35
Effect of surfactant administration on outcomes of adult patients in acute respiratory distress syndrome: a meta-analysis of randomized controlled trials. ( 30626363 )
2019
36
Gastrointestinal Bleeding in Patients With Acute Respiratory Distress Syndrome: A National Database Analysis. ( 30627277 )
2019
37
Mesenchymal stem cells with downregulated Hippo signaling attenuate lung injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome. ( 30628652 )
2019
38
EXPRESS: Analysis of Pulmonary Vascular Injury and Repair during Pseudomonas aeruginosa Infection-induced Pneumonia and Acute Respiratory Distress Syndrome. ( 30632898 )
2019
39
Association between Age and Acute Respiratory Distress Syndrome Development and Mortality following Trauma. ( 30633097 )
2019
40
Association Between Tidal Volumes Adjusted for Ideal Body Weight and Outcomes in Pediatric Acute Respiratory Distress Syndrome. ( 30640889 )
2019
41
Venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis. ( 30642776 )
2019
42
ECMO in severe acute respiratory distress syndrome. ( 30642777 )
2019
43
Comparison of geometric and algebraic methods to determine mechanical power in patients with acute respiratory distress syndrome. ( 30649592 )
2019
44
Acute Respiratory Distress Syndrome following Cardiac Surgery: Comparison of the American-European Consensus Conference Definition versus the Berlin Definition. ( 30650409 )
2019
45
Risk factors and prognosis of acute respiratory distress syndrome following abdominal surgery. ( 30651777 )
2019
46
Spontaneous Breathing in Acute Respiratory Distress Syndrome: Remains an Unanswered Question. ( 30653062 )
2019
47
Is Helmet Noninvasive Ventilation a Protective Factor for Long-Term Outcome in Acute Respiratory Distress Syndrome? ( 30653084 )
2019
48
The Acute Respiratory Distress Syndrome after Out-of-Hospital Cardiac Arrest: Incidence, Risk Factors, and Outcomes. ( 30654012 )
2019
49
Correlations of IL-17 and NF-κB gene polymorphisms with susceptibility and prognosis in Acute Respiratory Distress Syndrome in a Chinese population. ( 30655311 )
2019
50
Positive end-expiratory pressure titration with electrical impedance tomography and pressure-volume curve in severe acute respiratory distress syndrome. ( 30656479 )
2019

Variations for Acute Respiratory Distress Syndrome

Expression for Acute Respiratory Distress Syndrome

Search GEO for disease gene expression data for Acute Respiratory Distress Syndrome.

Pathways for Acute Respiratory Distress Syndrome

Pathways related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 CXCL8 IL1B IL6 LTA PLA2G7 TNF
2
Show member pathways
13.11 CXCL8 IL1B IL6 SFTPD TNF
3
Show member pathways
12.81 CXCL8 IL1B IL6 LTA TNF
4
Show member pathways
12.67 CXCL8 IL1B IL6 TNF
5
Show member pathways
12.62 IL1B IL6 LTA TNF
6
Show member pathways
12.53 CXCL8 IL1B IL6 LTA TNF
7
Show member pathways
12.28 CXCL8 IL1B IL6 TNF
8
Show member pathways
12.26 CXCL8 IL1B IL6 TNF
9
Show member pathways
12.2 CXCL8 IL1B IL6 LTA TNF
10
Show member pathways
12.18 CXCL8 IL1B IL6 TNF
11 12.14 CXCL8 IL1B IL6 TNF
12
Show member pathways
12 IL1B IL6 LTA TNF
13
Show member pathways
11.97 IL1B IL6 TNF
14 11.95 CXCL8 IL1B IL6 TNF
15 11.92 CXCL8 IL1B IL6 TNF
16 11.89 CXCL8 IL1B IL6
17 11.88 IL1B IL6 LTA TNF
18
Show member pathways
11.87 CXCL8 IL1B IL6 SFTPD TNF
19 11.85 IL1B IL6 TNF
20
Show member pathways
11.83 SFTPB SFTPC SFTPD
21 11.83 CXCL8 IL1B IL6 TNF
22 11.79 CXCL8 IL1B IL6
23 11.79 CXCL8 IL1B IL6 TNF
24 11.77 CXCL8 IL1B LTA TNF
25 11.75 IL1B LTA TNF
26 11.72 CXCL8 IL1B IL6 TNF
27 11.71 IL1B IL6 TNF
28 11.69 IL1B IL6 TNF
29 11.61 CXCL8 IL1B IL6 TNF
30 11.5 ELANE IL6 TNF
31
Show member pathways
11.5 CXCL8 IL1B IL6 TNF
32 11.47 IL1B IL6 TNF
33
Show member pathways
11.44 SFTPB SFTPC SFTPD
34 11.36 IL1B IL6 TNF
35 11.36 CXCL8 IL1B IL6 TNF
36 11.33 IL1B IL6 TNF
37 11.29 IL1B IL6 TNF
38 11.27 IL1B IL6 TNF
39 11.21 IL1B IL6 TNF
40 11.15 CXCL8 IL1B IL6 TNF
41
Show member pathways
11.12 SFTPB SFTPC SFTPD
42 11.11 IL1B PLA2G7
43 11.09 CXCL8 TNF
44 11.05 IL1B TNF
45 11.04 IL6 TNF
46 11 CXCL8 IL1B IL6 LTA TNF
47 10.96 CXCL8 IL1B IL6 LTA TNF
48 10.95 CXCL8 IL1B IL6 TNF
49 10.93 CXCL8 IL6 TNF
50 10.9 IL1B TNF

GO Terms for Acute Respiratory Distress Syndrome

Cellular components related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CXCL8 ELANE F5 IL1B IL6 LTA
2 extracellular region GO:0005576 9.4 CXCL8 ELANE F5 IL1B IL6 LTA
3 clathrin-coated endocytic vesicle GO:0045334 9.33 SFTPB SFTPC SFTPD
4 lamellar body GO:0042599 9.32 SFTPB SFTPC
5 multivesicular body lumen GO:0097486 9.26 SFTPB SFTPC

Biological processes related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.99 CXCL8 IL1B IL6 LTA TNF
2 inflammatory response GO:0006954 9.96 CXCL8 IL1B IL6 TNF
3 regulation of signaling receptor activity GO:0010469 9.95 CXCL8 IL1B IL6 LTA TNF
4 cytokine-mediated signaling pathway GO:0019221 9.93 CXCL8 IL1B IL6 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.82 IL1B IL6 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.81 IL6 LTA TNF
8 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL8 IL1B IL6 TNF
9 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B IL6 TNF
10 humoral immune response GO:0006959 9.76 IL6 LTA TNF
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.75 ELANE IL6 TNF
12 positive regulation of interferon-gamma production GO:0032729 9.69 IL1B LTA TNF
13 positive regulation of chemokine production GO:0032722 9.67 IL6 TNF
14 embryonic digestive tract development GO:0048566 9.67 CXCL8 TNF
15 negative regulation of lipid catabolic process GO:0050995 9.66 IL1B TNF
16 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.66 IL1B TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL1B TNF
19 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.63 ELANE TNF
20 negative regulation of lipid storage GO:0010888 9.62 IL6 TNF
21 positive regulation of chemokine biosynthetic process GO:0045080 9.62 IL1B TNF
22 regulation of establishment of endothelial barrier GO:1903140 9.61 IL1B TNF
23 response to glucocorticoid GO:0051384 9.61 IL6 TNF
24 positive regulation of phagocytosis GO:0050766 9.61 IL1B SFTPD TNF
25 respiratory gaseous exchange GO:0007585 9.58 SFTPB SFTPC SFTPD
26 positive regulation of fever generation GO:0031622 9.57 IL1B TNF
27 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.56 LTA TNF
28 cellular protein metabolic process GO:0044267 9.55 F5 IL6 SFTPB SFTPC SFTPD
29 sequestering of triglyceride GO:0030730 9.52 IL1B TNF
30 negative regulation of neurogenesis GO:0050768 9.5 IL1B IL6 TNF
31 negative regulation of chemokine biosynthetic process GO:0045079 9.48 ELANE IL6
32 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IL1B TNF
33 negative regulation of growth of symbiont in host GO:0044130 9.43 ELANE LTA TNF
34 positive regulation of neutrophil chemotaxis GO:0090023 9.37 CXCL8
35 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.37 LTA TNF
36 chronic inflammatory response to antigenic stimulus GO:0002439 9.24 TNF
37 positive regulation of neuroinflammatory response GO:0150078 9.13 IL1B IL6 TNF
38 positive regulation of glial cell proliferation GO:0060252 8.92 IL1B IL6 LTA TNF

Molecular functions related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL1B IL6 LTA TNF

Sources for Acute Respiratory Distress Syndrome

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
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70 SNOMED-CT via HPO
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72 TGDB
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75 UMLS via Orphanet
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