ALI
MCID: ACT210
MIFTS: 62

Acute Respiratory Distress Syndrome (ALI)

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Acute Respiratory Distress Syndrome

MalaCards integrated aliases for Acute Respiratory Distress Syndrome:

Name: Acute Respiratory Distress Syndrome 53
Respiratory Distress Syndrome, Adult 53 73
Non-Cardiogenic Pulmonary Edema 53 73
Acute Respiratory Distress 55 73
Acute Lung Injury 53 59
Increased-Permeability Pulmonary Edema 53
Adult Respiratory Distress Syndrome 53
Shock Lung 53
Stiff Lung 53
Ards 53
Ali 53

Characteristics:

Orphanet epidemiological data:

59
acute lung injury
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 59  
Rare respiratory diseases


External Ids:

Orphanet 59 ORPHA178320
MESH via Orphanet 45 D055371
UMLS via Orphanet 74 C0242488

Summaries for Acute Respiratory Distress Syndrome

NIH Rare Diseases : 53 Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood.  People who develop ARDS often are very ill with another disease or have major injuries. The condition leads to a buildup of fluid in the air sacs which prevents enough oxygen from passing into the bloodstream. Symptoms may include difficulty breathing, low blood pressure and organ failure, rapid breathing and shortness of breath.

MalaCards based summary : Acute Respiratory Distress Syndrome, also known as respiratory distress syndrome, adult, is related to respiratory distress syndrome in premature infants and adult respiratory distress syndrome, and has symptoms including dyspnea, respiratory distress and apnea. An important gene associated with Acute Respiratory Distress Syndrome is LTA (Lymphotoxin Alpha), and among its related pathways/superpathways are PAK Pathway and Toll-like Receptor Signaling Pathway. The drugs Curosurf and Infasurf have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and skin, and related phenotypes are immune system and mortality/aging

Wikipedia : 76 Acute respiratory distress syndrome (ARDS) is type of respiratory failure characterized by rapid onset... more...

Related Diseases for Acute Respiratory Distress Syndrome

Diseases in the Adult Respiratory Distress Syndrome family:

Acute Respiratory Distress Syndrome Adult Acute Respiratory Distress Syndrome

Diseases related to Acute Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 580)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome in premature infants 32.3 SFTPB SFTPC
2 adult respiratory distress syndrome 32.1 CXCL8 ELANE IL6 SFTPB SFTPC TNF
3 bronchopulmonary dysplasia 32.0 CXCL8 ELANE SFTPB
4 staphylococcal toxic shock syndrome 31.9 IL1B TNF
5 peritonitis 31.8 CXCL8 IL1B IL6 TNF
6 pulmonary edema 30.8 CXCL8 IL1B TNF
7 pustular psoriasis 30.5 ELANE PI3 TNF
8 malaria 30.5 CXCL8 IL1B IL6 LTA TNF
9 burns 30.5 IL1B TNF
10 bronchiolitis 30.5 CXCL8 IL6 TNF
11 adult-onset still's disease 30.4 IL1B IL6 TNF
12 viral infectious disease 30.4 CXCL8 IL1B IL6 TNF
13 leptospirosis 30.3 CXCL8 IL1B IL6 TNF
14 bronchiolitis obliterans 30.3 CXCL8 IL6 TNF
15 pyelonephritis 30.3 CXCL8 IL1B IL6 TNF
16 anca-associated vasculitis 30.2 IL6 TNF
17 cardiogenic shock 30.2 IL6 TNF
18 avian influenza 30.1 CXCL8 IL6 SFTPD TNF
19 pulmonary fibrosis 30.1 IL1B SFTPC SFTPD
20 surfactant dysfunction 30.1 SFTPB SFTPC
21 capillary leak syndrome 30.0 CXCL8 ELANE IL6
22 aortic aneurysm, familial abdominal, 1 30.0 ELANE IL1B IL6
23 pneumonia 30.0 CXCL8 ELANE IL1B IL6 SFTPB SFTPC
24 hemorrhagic fever with renal syndrome 30.0 CXCL8 IL6 TNF
25 dengue hemorrhagic fever 30.0 CXCL8 IL6 TNF
26 crohn's colitis 30.0 CXCL8 IL1B TNF
27 bronchitis 29.9 CXCL8 ELANE TNF
28 aseptic meningitis 29.9 CXCL8 IL1B TNF
29 dengue shock syndrome 29.9 IL1B IL6 TNF
30 q fever 29.9 IL1B IL6 TNF
31 chikungunya 29.9 IL1B IL6 TNF
32 arthritis 29.9 CXCL8 IL1B IL6 LTA TNF
33 psoriasis 29.9 CXCL8 IL1B IL6 LTA PI3 TNF
34 lyme disease 29.9 IL1B IL6 TNF
35 acute pancreatitis 29.9 CXCL8 ELANE IL6
36 respiratory failure 29.9 CXCL8 ELANE SFTPB SFTPC SFTPD TNF
37 kawasaki disease 29.9 ELANE IL6 TNF
38 toxoplasmosis 29.9 IL1B IL6 TNF
39 scorpion envenomation 29.9 IL6 TNF
40 aspergillosis 29.9 ELANE SFTPD TNF
41 endocarditis 29.8 CXCL8 IL6 TNF
42 acquired immunodeficiency syndrome 29.8 IL1B IL6 TNF
43 bacterial sepsis 29.8 CXCL8 ELANE TNF
44 meningitis 29.8 CXCL8 IL1B IL6 TNF
45 osteomyelitis 29.8 CXCL8 IL1B IL6 TNF
46 sleep apnea 29.8 CXCL8 IL1B IL6 TNF
47 cytomegalovirus infection 29.8 CXCL8 IL1B IL6 TNF
48 chlamydia 29.8 CXCL8 IL1B IL6 TNF
49 bacterial pneumonia 29.8 CXCL8 ELANE IL6 SFTPB SFTPD
50 multiple sclerosis 29.7 IL1B IL6 LTA TNF

Graphical network of the top 20 diseases related to Acute Respiratory Distress Syndrome:



Diseases related to Acute Respiratory Distress Syndrome

Symptoms & Phenotypes for Acute Respiratory Distress Syndrome

UMLS symptoms related to Acute Respiratory Distress Syndrome:


dyspnea, respiratory distress, apnea, hemoptysis, coughing, hoarseness, cheyne-stokes respiration, labored breathing

MGI Mouse Phenotypes related to Acute Respiratory Distress Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.76 ELANE IL1B IL6 LTA PLA2G7 SFTPC
2 mortality/aging MP:0010768 9.65 ELANE F5 IL1B IL6 LTA PLA2G7
3 respiratory system MP:0005388 9.1 IL6 LTA SFTPB SFTPC SFTPD TNF

Drugs & Therapeutics for Acute Respiratory Distress Syndrome

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Curosurf 18 PORACTANT ALFA Dey Laboratories October 1998
2
Infasurf 18 CALFACTANT ONY July 1998

Drugs for Acute Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 515)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisatracurium Approved Phase 4,Phase 3 96946-41-7
2
Midazolam Approved, Illicit Phase 4,Phase 3,Not Applicable 59467-70-8 4192
3
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
4
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
5
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
6
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
7
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
8
Racepinephrine Approved Phase 4,Phase 3,Phase 2 329-65-7 838
9
Budesonide Approved Phase 4,Phase 2,Not Applicable 51333-22-3 63006 5281004
10 Beractant Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 108778-82-1
11 Poractant alfa Approved Phase 4,Phase 2,Phase 3,Not Applicable 129069-19-8
12 Nefopam Approved, Investigational Phase 4 13669-70-0
13
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
14
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
15
Clonidine Approved Phase 4 4205-90-7 2803
16
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
17
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 103-90-2 1983
18
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
19
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 302-25-0
20
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
21
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Not Applicable 2921-57-5
22
Atracurium Approved, Experimental, Investigational Phase 4,Not Applicable 64228-79-1 47319
23
Metformin Approved Phase 4,Phase 2,Phase 3,Not Applicable 657-24-9 14219 4091
24
Carbon monoxide Approved, Investigational Phase 4,Phase 1 630-08-0 281
25
Atropine Approved, Vet_approved Phase 4,Phase 1,Not Applicable 51-55-8, 5908-99-6 174174
26 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
28
Ketamine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 6740-88-1 3821
29
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
30
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 57-83-0 5994
31
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 378-44-9 9782
32
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6
33
Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
34
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
35
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 57-27-2 5288826
36
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
37
Succinylcholine Approved Phase 4 306-40-1 5314
38
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1177-87-3
39
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-02-2 5743
40
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
41
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 113775-47-6 68602 5311068
42
Nifedipine Approved Phase 4,Phase 3,Not Applicable 21829-25-4 4485
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 437-38-7 3345
44
Misoprostol Approved Phase 4,Not Applicable 59122-46-2 5282381
45
Iron Approved Phase 4 7439-89-6 23925
46
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
47
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
48
Metronidazole Approved Phase 4,Phase 2,Phase 3,Not Applicable 443-48-1 4173
49
Labetalol Approved Phase 4 36894-69-6 3869
50
Serine Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 56-45-1 5951

Interventional clinical trials:

(show top 50) (show all 1338)
# Name Status NCT ID Phase Drugs
1 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
2 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
3 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4 propofol
4 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
5 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
6 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
7 Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
8 SLI MANEUVER and RESPIRATORY MORBIDITIES Unknown status NCT02887924 Phase 4
9 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
10 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
11 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
12 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
13 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
14 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
15 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
16 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
17 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
18 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
19 Preventing Recurrent Gestational Diabetes With Metformin Unknown status NCT02394158 Phase 4 Metformin;placebo
20 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
21 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
22 Corticosteroid Mediates Acute Respiratory Distress Syndrome Completed NCT02819453 Phase 4 Methylprednisolone
23 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
24 Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study) Completed NCT02166853 Phase 4 sevoflurane;midazolam
25 Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome Completed NCT00391105 Phase 4 Remifentanil
26 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
27 Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide Completed NCT01923844 Phase 4 exogenous surfactant
28 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Completed NCT01042600 Phase 4
29 Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
30 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
31 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
32 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
33 Laryngoscope Versus CMAC for Endotracheal Intubation in Patients Undergoing Emergent Airway Management Completed NCT01710891 Phase 4
34 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
35 Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery Completed NCT02635542 Phase 4 Succinylcholine;Cisatracurium
36 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
37 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
38 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
39 On Versus Off Pump Myocardial Revascularization Study Completed NCT01290952 Phase 4
40 Inflammatory Response Secondary Using Intravenous Anesthesia Versus Inhalation Anesthesia With Halogenated Agents Completed NCT02168751 Phase 4 propofol;Sevoflurane
41 Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation Completed NCT02962999 Phase 4 Ketamine;Saline
42 Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix Completed NCT02338830 Phase 4 Progesterone
43 A Randomized Trial Comparing the Impact of One Versus Two Courses of Antenatal Steroids (ACS) on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
44 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
45 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
46 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
47 Long Protocol and Freeze All Embryos vs Antagonist Protocol With Fresh Embryo Transfer in PCOS Patients Undergoing ICSI Completed NCT03118830 Phase 4 Triptorelin;cetrorelix;Recombinant Follicle Stimulating Hormone
48 Recruitment Maneuver After Intubation Completed NCT01014299 Phase 4
49 Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study) Completed NCT01282996 Phase 4
50 Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) Completed NCT02253082 Phase 4 OctaplasLG®

Search NIH Clinical Center for Acute Respiratory Distress Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Acute Respiratory Distress Syndrome

Anatomical Context for Acute Respiratory Distress Syndrome

MalaCards organs/tissues related to Acute Respiratory Distress Syndrome:

41
Lung, Neutrophil, Skin, Liver, Brain, Heart, Endothelial

Publications for Acute Respiratory Distress Syndrome

Articles related to Acute Respiratory Distress Syndrome:

(show top 50) (show all 1490)
# Title Authors Year
1
Vascular endothelial growth factor increased the permeability of respiratory barrier in acute respiratory distress syndrome model in mice. ( 30551503 )
2019
2
Neuromuscular blocking agents for acute respiratory distress syndrome. ( 30396789 )
2019
3
Heart-lung interactions in acute respiratory distress syndrome: pathophysiology, detection and management strategies. ( 29430444 )
2018
4
Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia. ( 29431568 )
2018
5
The relationship between high-dose corticosteroid treatment and mortality in acute respiratory distress syndrome: a retrospective and observational study using a nationwide administrative database in Japan. ( 29415701 )
2018
6
Acute respiratory distress syndrome in a man with Epstein-Barr virus infection-induced hypocomplementemic urticarial vasculitis. ( 29458992 )
2018
7
Naloxone-Induced Non-Cardiogenic Pulmonary Edema: A Case Report. ( 29749582 )
2018
8
The Use of Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome in Severe Burns Without Inhalation Injury. ( 29901798 )
2018
9
Antipsychotics, Delirium, and Acute Respiratory Distress Syndrome: What is the Link? ( 29444340 )
2018
10
A new side effect of synthetic cannabinoid use by the bucket (waterpipe) method: Acute respiratory distress syndrome (ARDS). ( 29942884 )
2018
11
Understanding Macrophages in Acute Respiratory Distress Syndrome: From Pathophysiology to Precision Medicine. ( 29912110 )
2018
12
Alk5/Runx1 signaling mediated by extracellular vesicles promotes vascular repair in acute respiratory distress syndrome. ( 29931538 )
2018
13
NF-I_B-Induced MicroRNA-211 Inhibits Interleukin-10 in Macrophages of Rats with Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. ( 29402831 )
2018
14
Genetic Variation in MAP3K1 Associates with Ventilator-Free Days in Acute Respiratory Distress Syndrome. ( 28858533 )
2018
15
Extracorporeal Membrane Oxygenation in a 39-Year-Old Man with Traumatic Pulmonary Contusions and Acute Respiratory Distress Syndrome. ( 29935697 )
2018
16
Acute respiratory distress syndrome and Plasmodium ovale malaria. ( 29886120 )
2018
17
Low endocan levels are predictive of Acute Respiratory Distress Syndrome in severe sepsis and septic shock. ( 29957509 )
2018
18
Nonpulmonary risk factors of acute respiratory distress syndrome in patients with septic bacteraemia. ( 29898577 )
2018
19
Increased circulating microRNA-122 is associated with mortality and acute liver injury in the acute respiratory distress syndrome. ( 29935532 )
2018
20
miR-155-5p Promotes Progression of Acute Respiratory Distress Syndrome by Inhibiting Differentiation of Bone Marrow Mesenchymal Stem Cells to Alveolar Type II Epithelial Cells. ( 29936517 )
2018
21
Focal Encephalitis, Meningitis and Acute Respiratory Distress Syndrome Associated with Influenza A Infection. ( 29402867 )
2018
22
The Randomized Educational Acute Respiratory Distress Syndrome Diagnosis Study: A Trial to Improve the Radiographic Diagnosis of Acute Respiratory Distress Syndrome. ( 29438110 )
2018
23
Estimation of true driving pressure during airway pressure release ventilation : Discussion on "Early application of airway pressure release ventilation may reduce the duration of mechanical ventilation in acute respiratory distress syndrome". ( 29947887 )
2018
24
Setting PEEP in Pediatric Acute Respiratory Distress Syndrome: Cookbook or Individualized Titration? ( 29958026 )
2018
25
Factors associated with missed assessments in a 2-year longitudinal study of acute respiratory distress syndrome survivors. ( 29907087 )
2018
26
Anticoagulant therapy in acute respiratory distress syndrome. ( 29430453 )
2018
27
Subtypes of pediatric acute respiratory distress syndrome have different predictors of mortality. ( 29971591 )
2018
28
Unilateral Acute Respiratory Distress Syndrome with Contralateral Pulmonary Artery Agenesis. ( 29125306 )
2018
29
Pediatric Acute Respiratory Distress Syndrome - Increase the PEEP? ( 29451804 )
2018
30
Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration. ( 29310581 )
2018
31
The effects of hemoglobin glutamer-200 and iNO on pulmonary vascular tone and arterial oxygenation in an experimental acute respiratory distress syndrome. ( 29425776 )
2018
32
Genome Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor. ( 29425463 )
2018
33
Implementation of preemptive fluid strategy as a bundle to prevent fluid overload in children with acute respiratory distress syndrome and sepsis. ( 29945586 )
2018
34
Distinctive Roles and Mechanisms of Human Neutrophil Peptides in Experimental Sepsis and Acute Respiratory Distress Syndrome. ( 29979223 )
2018
35
Acute respiratory distress syndrome without identifiable risk factors: A secondary analysis of the ARDS network trials. ( 29898428 )
2018
36
Effects of hypercapnia in acute respiratory distress syndrome. ( 29430454 )
2018
37
Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care. ( 29958249 )
2018
38
Severe Plasmodium ovale malaria complicated by acute respiratory distress syndrome in a young Caucasian man. ( 29609605 )
2018
39
An Exploratory Reanalysis of the Randomized Trial on Efficacy of Corticosteroids as Rescue Therapy for the Late Phase of Acute Respiratory Distress Syndrome. ( 29432350 )
2018
40
Is Overall Mortality the Right Composite Endpoint in Clinical Trials of Acute Respiratory Distress Syndrome? ( 29420341 )
2018
41
Pediatric acute respiratory distress syndrome - current views. ( 29434764 )
2018
42
Macrolide therapy is associated with reduced mortality in acute respiratory distress syndrome (ARDS) patients. ( 29430441 )
2018
43
Effect of vitamin D deficiency in Korean patients with acute respiratory distress syndrome. ( 29914229 )
2018
44
Diagnosis of acute respiratory distress syndrome by exhaled breath analysis. ( 29430450 )
2018
45
Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. ( 29895331 )
2018
46
Salvage extracorporeal membrane oxygenation in induction-associated acute respiratory distress syndrome in acute leukemia patients: A case series. ( 30223700 )
2018
47
Acute respiratory distress syndrome after the use of gadolinium contrast agent. ( 30450277 )
2018
48
Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation: a systematic review and meta-analysis. ( 30453220 )
2018
49
Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. ( 30455077 )
2018
50
Respiratory mechanics in patients with acute respiratory distress syndrome. ( 30460256 )
2018

Variations for Acute Respiratory Distress Syndrome

Expression for Acute Respiratory Distress Syndrome

Search GEO for disease gene expression data for Acute Respiratory Distress Syndrome.

Pathways for Acute Respiratory Distress Syndrome

Pathways related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 CXCL8 IL1B IL6 LTA PLA2G7 TNF
2
Show member pathways
12.94 CXCL8 IL1B IL6 SFTPD TNF
3
Show member pathways
12.81 CXCL8 IL1B IL6 LTA TNF
4
Show member pathways
12.73 CXCL8 IL1B IL6 LTA TNF
5
Show member pathways
12.67 CXCL8 IL1B IL6 TNF
6
Show member pathways
12.62 IL1B IL6 LTA TNF
7
Show member pathways
12.28 CXCL8 IL1B IL6 TNF
8
Show member pathways
12.26 CXCL8 IL1B IL6 TNF
9
Show member pathways
12.2 CXCL8 IL1B IL6 LTA TNF
10
Show member pathways
12.18 CXCL8 IL1B IL6 TNF
11 12.14 CXCL8 IL1B IL6 TNF
12
Show member pathways
12 IL1B IL6 LTA TNF
13
Show member pathways
11.97 IL1B IL6 TNF
14 11.95 CXCL8 IL1B IL6 TNF
15 11.92 CXCL8 IL1B IL6 TNF
16 11.89 CXCL8 IL1B IL6
17 11.88 IL1B IL6 LTA TNF
18
Show member pathways
11.87 CXCL8 IL1B IL6 SFTPD TNF
19 11.85 IL1B IL6 TNF
20
Show member pathways
11.83 SFTPB SFTPC SFTPD
21 11.82 CXCL8 IL1B IL6 TNF
22 11.79 CXCL8 IL1B IL6
23 11.79 CXCL8 IL1B IL6 TNF
24 11.77 CXCL8 IL1B LTA TNF
25 11.75 IL1B LTA TNF
26 11.71 IL1B IL6 TNF
27 11.71 CXCL8 IL1B IL6 TNF
28 11.69 IL1B IL6 TNF
29 11.61 CXCL8 IL1B IL6 TNF
30 11.5 ELANE IL6 TNF
31
Show member pathways
11.5 CXCL8 IL1B IL6 TNF
32 11.47 IL1B IL6 TNF
33
Show member pathways
11.44 SFTPB SFTPC SFTPD
34 11.36 CXCL8 IL1B IL6 TNF
35 11.34 IL1B IL6 TNF
36 11.33 IL1B IL6 TNF
37 11.29 IL1B IL6 TNF
38 11.27 IL1B IL6 TNF
39 11.21 IL1B IL6 TNF
40 11.15 CXCL8 IL1B IL6 TNF
41
Show member pathways
11.12 SFTPB SFTPC SFTPD
42 11.11 IL1B PLA2G7
43 11.09 CXCL8 TNF
44 11.05 IL1B TNF
45 11.04 IL6 TNF
46 11 CXCL8 IL1B IL6 LTA TNF
47 10.96 CXCL8 IL1B IL6 LTA TNF
48 10.95 CXCL8 IL1B IL6 TNF
49 10.93 CXCL8 IL6 TNF
50 10.9 IL1B TNF

GO Terms for Acute Respiratory Distress Syndrome

Cellular components related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CXCL8 ELANE F5 IL1B IL6 LTA
2 extracellular region GO:0005576 9.4 CXCL8 ELANE F5 IL1B IL6 LTA
3 clathrin-coated endocytic vesicle GO:0045334 9.33 SFTPB SFTPC SFTPD
4 lamellar body GO:0042599 9.32 SFTPB SFTPC
5 multivesicular body lumen GO:0097486 9.26 SFTPB SFTPC

Biological processes related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.99 CXCL8 IL1B IL6 LTA TNF
2 inflammatory response GO:0006954 9.96 CXCL8 IL1B IL6 TNF
3 regulation of signaling receptor activity GO:0010469 9.95 CXCL8 IL1B IL6 LTA TNF
4 cytokine-mediated signaling pathway GO:0019221 9.93 CXCL8 IL1B IL6 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.82 IL1B IL6 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.81 IL6 LTA TNF
8 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL8 IL1B IL6 TNF
9 response to glucocorticoid GO:0051384 9.78 IL1B IL6 TNF
10 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B IL6 TNF
11 humoral immune response GO:0006959 9.76 IL6 LTA TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.75 ELANE IL6 TNF
13 positive regulation of interferon-gamma production GO:0032729 9.69 IL1B LTA TNF
14 positive regulation of neutrophil chemotaxis GO:0090023 9.68 CXCL8 IL1B
15 positive regulation of chemokine production GO:0032722 9.67 IL6 TNF
16 embryonic digestive tract development GO:0048566 9.67 CXCL8 TNF
17 negative regulation of lipid catabolic process GO:0050995 9.66 IL1B TNF
18 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.66 IL1B TNF
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL1B TNF
21 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.63 ELANE TNF
22 negative regulation of lipid storage GO:0010888 9.62 IL6 TNF
23 positive regulation of chemokine biosynthetic process GO:0045080 9.62 IL1B TNF
24 regulation of establishment of endothelial barrier GO:1903140 9.61 IL1B TNF
25 positive regulation of phagocytosis GO:0050766 9.61 IL1B SFTPD TNF
26 respiratory gaseous exchange GO:0007585 9.58 SFTPB SFTPC SFTPD
27 positive regulation of fever generation GO:0031622 9.57 IL1B TNF
28 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.56 LTA TNF
29 cellular protein metabolic process GO:0044267 9.55 F5 IL6 SFTPB SFTPC SFTPD
30 chronic inflammatory response to antigenic stimulus GO:0002439 9.54 IL1B TNF
31 sequestering of triglyceride GO:0030730 9.52 IL1B TNF
32 negative regulation of neurogenesis GO:0050768 9.5 IL1B IL6 TNF
33 negative regulation of chemokine biosynthetic process GO:0045079 9.48 ELANE IL6
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IL1B TNF
35 negative regulation of growth of symbiont in host GO:0044130 9.43 ELANE LTA TNF
36 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.37 LTA TNF
37 positive regulation of neuroinflammatory response GO:0150078 9.13 IL1B IL6 TNF
38 positive regulation of glial cell proliferation GO:0060252 8.92 IL1B IL6 LTA TNF

Molecular functions related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL1B IL6 LTA TNF

Sources for Acute Respiratory Distress Syndrome

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