Acute Retinal Necrosis Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACT022 MIFTS: 30	Acute Retinal Necrosis Syndrome Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Acute Retinal Necrosis Syndrome

MalaCards integrated aliases for Acute Retinal Necrosis Syndrome:

Name: Acute Retinal Necrosis Syndrome ¹² ¹⁵ ¹⁷

Retinal Necrosis Syndrome, Acute ⁴³ ⁷¹

Acute Retinal Necrosis ¹²

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3611

MeSH ⁴³ D015882

SNOMED-CT ⁶⁷ 231986000

EFO ¹⁷ EFO_1000795

UMLS ⁷¹ C0035319

Sources

Summaries for Acute Retinal Necrosis Syndrome

MalaCards based summary : Acute Retinal Necrosis Syndrome, also known as retinal necrosis syndrome, acute, is related to neuroretinitis and retinal vasculitis. An important gene associated with Acute Retinal Necrosis Syndrome is SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5), and among its related pathways/superpathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Cell adhesion molecules (CAMs). The drugs Antiviral Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related phenotype is homeostasis/metabolism.

Wikipedia : ⁷⁴ Acute Retinal Necrosis (ARN), is a medical inflammatory condition of the eye. The condition presents... more...

Sources

Related Diseases for Acute Retinal Necrosis Syndrome

Diseases related to Acute Retinal Necrosis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 400)

#	Related Disease	Score	Top Affiliating Genes
1	neuroretinitis	31.2	MRAP CD40LG CD4
2	retinal vasculitis	30.7	MRAP CD40LG CD4
3	chickenpox	30.3	GYPC CD8A CD40LG CD4
4	optic papillitis	30.3	MRAP CD40LG CD4
5	asymptomatic neurosyphilis	30.3	CD40LG CD4
6	pustulosis of palm and sole	30.3	SIGLEC5 MRAP
7	cranial nerve palsy	30.2	CD40LG CD4
8	choroiditis	30.1	MRAP CD40LG CD4
9	endophthalmitis	29.9	MRAP CD4 ASPRV1
10	herpes simplex	29.9	TNFRSF14 NECTIN1 GYPC CD8A
11	hypopyon	29.9	MRAP CD4 ASPRV1
12	viral encephalitis	29.8	CD8A CD40LG CD4
13	iridocyclitis	29.8	MRAP CD40LG CD4 ASPRV1
14	optic nerve disease	29.8	CD8A CD40LG CD4
15	dacryoadenitis	29.7	CD8A CD4
16	herpes zoster	29.6	GYPC CD8A CD40LG CD4
17	syphilis	29.5	MRAP CD8A CD40LG CD4
18	exanthem	29.5	CD8A CD40LG CD4
19	meningoencephalitis	29.5	CD8A CD40LG CD4
20	cellulitis	29.5	CD8A CD40LG CD4
21	cerebritis	29.4	CD8A CD40LG CD4
22	bacterial infectious disease	29.4	CD8A CD40LG CD4
23	sarcoidosis 1	29.4	MRAP CD8A CD40LG CD4
24	progressive multifocal leukoencephalopathy	29.4	CD8A CD40LG CD4
25	chorioretinitis	29.4	MRAP CD8A CD40LG CD4
26	panuveitis	29.4	MRAP CD8A CD40LG CD4
27	pfeiffer syndrome	29.4	CD8A CD40LG CD4
28	cytomegalovirus retinitis	29.3	GYPC CD8A CD40LG CD4
29	iritis	29.2	MRAP CD8A CD40LG CD4
30	eye disease	29.2	MRAP CD8A CD40LG CD4
31	genital herpes	28.0	TNFRSF14 NECTIN1 GYPC CD8A CD40LG CD4
32	retinal detachment	10.6
33	retinitis	10.6
34	ocular tuberculosis	10.4	MRAP CD4
35	american histoplasmosis	10.4	CD40LG CD4
36	syphilitic meningitis	10.4	CD40LG CD4
37	uveitis	10.4
38	latent syphilis	10.4	CD40LG CD4
39	gastroduodenitis	10.4	CD40LG CD4
40	primary syphilis	10.4	CD40LG CD4
41	necrotizing ulcerative gingivitis	10.4	CD40LG CD4
42	chorioretinal scar	10.4	SIGLEC5 CD40LG
43	tertiary neurosyphilis	10.4	CD40LG CD4
44	epiglottitis	10.4	SIGLEC5 CD40LG
45	bacillary angiomatosis	10.4	CD40LG CD4
46	meningovascular neurosyphilis	10.4	CD40LG CD4
47	opportunistic bacterial infectious disease	10.4	CD40LG CD4
48	chronic orbital inflammation	10.4	MRAP CD40LG
49	subacute bacterial endocarditis	10.4	SIGLEC5 CD40LG
50	cerebral lymphoma	10.4	CD40LG CD4

Graphical network of the top 20 diseases related to Acute Retinal Necrosis Syndrome:

Sources

Symptoms & Phenotypes for Acute Retinal Necrosis Syndrome

MGI Mouse Phenotypes related to Acute Retinal Necrosis Syndrome:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.28	ARNT CD4 CD40LG GYPC HS3ST1 MRAP

Sources

Drugs & Therapeutics for Acute Retinal Necrosis Syndrome

Drugs for Acute Retinal Necrosis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Antiviral Agents
2	Anti-Infective Agents

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	The Necessity and Optimal Time for Performing Pars Plana Vitrectomy in Acute Retinal Necrosis Patients	Completed	NCT03260049
2	Prophylactic Laser Photocoagulation and Vitrectomy for Acute Retinal Necrosis	Completed	NCT02222857

Search NIH Clinical Center for Acute Retinal Necrosis Syndrome

Cochrane evidence based reviews: retinal necrosis syndrome, acute

Sources

Genetic Tests for Acute Retinal Necrosis Syndrome

Sources

Anatomical Context for Acute Retinal Necrosis Syndrome

MalaCards organs/tissues related to Acute Retinal Necrosis Syndrome:

⁴⁰

Eye, Retina

Sources

Publications for Acute Retinal Necrosis Syndrome

Articles related to Acute Retinal Necrosis Syndrome:

(show top 50) (show all 173)

#	Title	Authors	PMID	Year
1	Visual outcome and poor prognostic factors in acute retinal necrosis syndrome. ⁶¹	Paolo M...Yan GC	32328756	2020
2	Aflibercept in the management of acute retinal necrosis syndrome-related macular edema. ⁶¹	Ortega-Evangelio L...Tomas-Torrent JM	28967076	2018
3	Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report. ⁶¹	Zhou C...Fang S	27698716	2016
4	[Clinical features of viral encephalitis with bilateral acute retinal necrosis syndrome]. ⁶¹	Hou X...Jiang H	27807336	2016
5	[Role of oral antiviral therapy in the treatment of acute retinal necrosis]. ⁶¹	Haouzi SE...Daoudi R	27795766	2016
6	Viral encephalitis complicated by acute retinal necrosis syndrome: A case report. ⁶¹	Liang ZG...Yu GP	26622338	2015
7	Delayed onset of bilateral acute retinal necrosis syndrome: a 46-year interval. ⁶¹	La Cava M...Zito R	24117381	2015
8	Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome. ⁶¹	Yeh S...Flaxel CJ	25215870	2014
9	Good visual outcome in an immunocompromised patient with bilateral acute retinal necrosis syndrome: A case report. ⁶¹	Marrocos de Aragao RE...Ramos CS	25278806	2014
10	Toll like receptors and acute retinal necrosis syndrome- evaluating the association. ⁶¹	Pathak S	25272391	2014
11	Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome (an American Ophthalmological Society thesis). ⁶¹	Flaxel CJ...Lauer AK	24385671	2013
12	[Factors associated with visual prognosis of acute retinal necrosis syndrome]. ⁶¹	Wen X...Zhao C	23866700	2013
13	Efficacy and necessity of prophylactic vitrectomy for acute retinal necrosis syndrome. ⁶¹	Luo YH...Guo XJ	22937510	2012
14	Posterior scleritis resembling acute retinal necrosis syndrome. ⁶¹	Badal J...Garcia-Arumi J	25390725	2012
15	Timing of prophylactic and early vitrectomy for first-presenting or recurrent acute retinal necrosis syndrome. ⁶¹	Matsuo T	23254584	2012
16	Indocyanine green angiography findings in acute retinal necrosis syndrome. ⁶¹	Bissig A...Guex-Crosier Y	21484641	2011
17	Kyrieleis plaques associated with acute retinal necrosis from herpes simplex virus type 2. ⁶¹	Witmer MT...Madow B	25390418	2011
18	Unilateral acute retinal necrosis in a multiple sclerosis patient treated with high-dose systemic steroids. ⁶¹	Saatci AO...Ada E	20524142	2010
19	[Pars plana vitrectomy in patients with acute retinal necrosis syndrome: surgical results in 52 patients]. ⁶¹	Usui Y...Goto H	20432961	2010
20	[Acute retinal necrosis]. ⁶¹	Gandorfer A...Thurau S	19693512	2009
21	Isolated unilateral acute retinal necrosis syndrome as the initial manifestation of HIV infection. ⁶¹	Gharai S...Vohra R	19642242	2009
22	[Management of acute retinal necrosis syndrome with cystoid macular edema: a case report]. ⁶¹	Izambart C...Gastaud P	19515316	2009
23	Herpetic encephalitis is a risk factor for acute retinal necrosis. ⁶¹	Vandercam T...Van der Lelij A	18852442	2008
24	Overview and diagnosis of acute retinal necrosis syndrome. ⁶¹	Usui Y...Goto H	18584564	2008
25	Epstein-Barr virus and acute retinal necrosis in a 5-year-old immunocompetent child. ⁶¹	Gallego-Pinazo R...Pinazo-Duran MD	19668736	2008
26	[Retinal manifestations of infectious diseases]. ⁶¹	Perez de Arcelus M...Garcia Layana A	19169295	2008
27	[Acute retinal necrosis syndrome following chickenpox]. ⁶¹	Bolivar G...Pareja J	17846952	2007
28	Three consecutive episodes of acute retinal necrosis due to herpes simplex-1 over twelve years following herpetic encephalitis. ⁶¹	Klein A...Lefebvre P	17972228	2007
29	Treatment of acute retinal necrosis syndrome with oral antiviral medications. ⁶¹	Aizman A...Elner SG	17123607	2007
30	[Acute retinal necrosis syndrome]. ⁶¹	Branisteanu D...Medvichi R	18543676	2007
31	Catastrophic acute retinal necrosis syndrome associated with diffuse orbital cellulitis: a case report. ⁶¹	Rozenbaum O...Bodaghi B	16628421	2007
32	Prophylactic vitrectomy in acute retinal necrosis syndrome. ⁶¹	Berker N...Soykan E	16858447	2007
33	Macular exudation as the presenting feature of acute retinal necrosis syndrome. ⁶¹	Minamoto A...Mishima HK	25390239	2007
34	Bilateral acute retinal necrosis syndrome following herpes simplex type 1 encephalitis. ⁶¹	Bristow EA...Pandit RJ	16410814	2006
35	Treatment of acute retinal necrosis syndrome. ⁶¹	Aizman A	16969431	2006
36	Unilateral recurrent acute retinal necrosis syndrome caused by cytomegalovirus in an immune-competent adult. ⁶¹	Voros GM...Griffiths PG	16761257	2006
37	Ocular herpes simplex: changing epidemiology, emerging disease patterns, and the potential of vaccine prevention and therapy. ⁶¹	Pepose JS...Morrison LA	16490506	2006
38	High dosage of oral valaciclovir as an alternative treatment of varicella zoster acute retinal necrosis syndrome. ⁶¹	Guex-Crosier Y...Meylan PR	15776013	2006
39	Vitrectomy and silicone oil tamponade as an initial surgery for retinal detachment after acute retinal necrosis syndrome. ⁶¹	Matsuo T	15804777	2005
40	Necrotising retinopathies simulating acute retinal necrosis syndrome. ⁶¹	Balansard B...Lehoang P	15615755	2005
41	[Bilateral acute retinal necrosis syndrome associated with meningoencephalitis caused by herpes simplex virus 2. A case report]. ⁶¹	Cardine S...Benzacken L	15499278	2004
42	Clinical characteristics of acute HSV-2 retinal necrosis. ⁶¹	Tran TH...Bodaghi B	15126152	2004
43	[Necrotic herpetic retinitis]. ⁶¹	Fardeau C	15179313	2004
44	Acute retinal necrosis syndrome: clinical manifestations and visual outcomes. ⁶¹	Chen HP...Kao ML	15148997	2004
45	Interferon gamma expression and clinical features in patients with acute retinal necrosis syndrome. ⁶¹	Abe T...Tamai M	12928903	2003
46	Surgical treatment of retinal detachment following acute retinal necrosis syndrome: surgical results in four patients. ⁶¹	Hou CH...Ho CL	14765754	2003
47	[Toxoplasma gondii and necrotizing retinitis: a case report]. ⁶¹	Balayre S...Gobert F	14586227	2003
48	[Brivudine as an alternative systemic therapy to aciclovir and ganciclovir in acute retinal necrosis syndrome due to varicella-zoster virus]. ⁶¹	Vij O...Schilling H	14577039	2003
49	Acute retinal necrosis following epidural steroid injections. ⁶¹	Browning DJ	12834695	2003
50	Polymerase chain reaction as a rapid diagnostic tool for therapy of acute retinal necrosis syndrome. ⁶¹	Gargiulo F...Manca N	12526051	2003

Sources

Genes for Acute Retinal Necrosis Syndrome

Genes related to Acute Retinal Necrosis Syndrome (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SIGLEC5	Sialic Acid Binding Ig Like Lectin 5	Protein Coding	7.3	DISEASES inferred ¹⁵ ¹⁵
2	CD4	CD4 Molecule	Protein Coding	6.57	DISEASES inferred ¹⁵
3	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	6.49	DISEASES inferred ¹⁵
4	TGIF1	TGFB Induced Factor Homeobox 1	Protein Coding	6.29	GeneCards inferred via : Publications (show sections)
5	CD40LG	CD40 Ligand	Protein Coding	6.18	DISEASES inferred ¹⁵
6	NECTIN1	Nectin Cell Adhesion Molecule 1	Protein Coding	5.78	DISEASES inferred ¹⁵
7	GYPC	Glycophorin C (Gerbich Blood Group)	Protein Coding	5.58	DISEASES inferred ¹⁵
8	ASPRV1	Aspartic Peptidase Retroviral Like 1	Protein Coding	5.49	DISEASES inferred ¹⁵
9	TNFRSF14	TNF Receptor Superfamily Member 14	Protein Coding	5.48	DISEASES inferred ¹⁵
10	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	5.39	DISEASES inferred ¹⁵
11	CD8A	CD8a Molecule	Protein Coding	5.34	DISEASES inferred ¹⁵
12	HS3ST1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 1	Protein Coding	5.23	DISEASES inferred ¹⁵

Sources

Variations for Acute Retinal Necrosis Syndrome

Sources

Expression for Acute Retinal Necrosis Syndrome

Search GEO for disease gene expression data for Acute Retinal Necrosis Syndrome.

Sources

Pathways for Acute Retinal Necrosis Syndrome

Pathways related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁵	11.46	SIGLEC5 CD8A CD40LG
2	Cell adhesion molecules (CAMs) ³⁶	11.09	NECTIN1 CD8A CD40LG CD4
3	Primary immunodeficiency ³⁶	10.71	CD8A CD40LG CD4

Sources

GO Terms for Acute Retinal Necrosis Syndrome

Cellular components related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	8.92	TNFRSF14 CD8A CD40LG CD4

Biological processes related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.02	TNFRSF14 NECTIN1 CD8A CD40LG CD4

Molecular functions related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	virus receptor activity	GO:0001618	9.13	TNFRSF14 NECTIN1 CD4
2	coreceptor activity	GO:0015026	8.8	NECTIN1 CD8A CD4

Sources

Sources for Acute Retinal Necrosis Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia