MCID: ACT022
MIFTS: 29

Acute Retinal Necrosis Syndrome

Categories: Eye diseases

Aliases & Classifications for Acute Retinal Necrosis Syndrome

MalaCards integrated aliases for Acute Retinal Necrosis Syndrome:

Name: Acute Retinal Necrosis Syndrome 12 15
Retinal Necrosis Syndrome, Acute 44 73
Acute Retinal Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3611
MeSH 44 D015882
UMLS 73 C0035319

Summaries for Acute Retinal Necrosis Syndrome

MalaCards based summary : Acute Retinal Necrosis Syndrome, also known as retinal necrosis syndrome, acute, is related to herpes simplex and encephalitis. An important gene associated with Acute Retinal Necrosis Syndrome is TGIF1 (TGFB Induced Factor Homeobox 1). The drugs Temazepam and Hypnotics and Sedatives have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial.

Wikipedia : 76 Acute Retinal Necrosis (ARN), is a medical inflammatory condition of the eye. The condition presents... more...

Related Diseases for Acute Retinal Necrosis Syndrome

Diseases related to Acute Retinal Necrosis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 herpes simplex 30.1 NECTIN1 TNFRSF14
2 encephalitis 10.2
3 retinal detachment 10.2
4 retinitis 10.2
5 chickenpox 10.0
6 neonatal herpes 10.0
7 choroiditis 10.0
8 central retinal artery occlusion 10.0
9 acquired immunodeficiency syndrome 10.0
10 retinal artery occlusion 10.0
11 uveitis 10.0
12 dermatitis 10.0
13 viral encephalitis 10.0
14 panuveitis 9.9
15 optic nerve disease 9.9
16 neuropathy 9.9
17 toxoplasmosis 9.9
18 anterior uveitis 9.9
19 herpes zoster ophthalmicus 9.9
20 cone-rod dystrophy 2 9.8 TNFRSF14 UNC119
21 cytomegalovirus retinitis 9.8
22 neuroretinitis 9.8
23 viral meningitis 9.8
24 orbital cellulitis 9.8
25 scleritis 9.8
26 posterior scleritis 9.8
27 cellulitis 9.8
28 macular retinal edema 9.8
29 human immunodeficiency virus infectious disease 9.8
30 herpes zoster 9.8
31 meningitis 9.8
32 herpes simplex encephalitis 9.8
33 cleft lip/palate-ectodermal dysplasia syndrome 9.8 NECTIN1 TNFRSF14
34 exudative vitreoretinopathy 1 9.7
35 keratitis, hereditary 9.7
36 myoclonus and ataxia 9.7
37 wiskott-aldrich syndrome 9.7
38 ischemic optic neuropathy 9.7
39 meningoencephalitis 9.7
40 fourth cranial nerve palsy 9.7
41 vogt-koyanagi-harada disease 9.7
42 retinal vascular occlusion 9.7
43 encephalomalacia 9.7
44 retinal vascular disease 9.7
45 central nervous system disease 9.7
46 cranial nerve palsy 9.7
47 syphilis 9.7
48 progressive multifocal leukoencephalopathy 9.7
49 macular holes 9.7
50 nervous system disease 9.7

Graphical network of the top 20 diseases related to Acute Retinal Necrosis Syndrome:



Diseases related to Acute Retinal Necrosis Syndrome

Symptoms & Phenotypes for Acute Retinal Necrosis Syndrome

Drugs & Therapeutics for Acute Retinal Necrosis Syndrome

Drugs for Acute Retinal Necrosis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temazepam Approved, Investigational 846-50-4 5391
2 Hypnotics and Sedatives
3 Anti-Anxiety Agents
4 Anti-Infective Agents
5 Central Nervous System Depressants
6 GABA Agents
7 Neurotransmitter Agents
8 Tranquilizing Agents
9 Psychotropic Drugs
10 Antiviral Agents
11 GABA Modulators

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prophylactic Laser Photocoagulation and Vitrectomy for Acute Retinal Necrosis Completed NCT02222857
2 The Necessity and Optimal Time for Performing Pars Plana Vitrectomy in Acute Retinal Necrosis Patients Completed NCT03260049
3 Uveitis Gene-Expression Profiling Completed NCT00874471

Search NIH Clinical Center for Acute Retinal Necrosis Syndrome

Cochrane evidence based reviews: retinal necrosis syndrome, acute

Genetic Tests for Acute Retinal Necrosis Syndrome

Anatomical Context for Acute Retinal Necrosis Syndrome

MalaCards organs/tissues related to Acute Retinal Necrosis Syndrome:

41
Eye, Endothelial

Publications for Acute Retinal Necrosis Syndrome

Articles related to Acute Retinal Necrosis Syndrome:

(show top 50) (show all 105)
# Title Authors Year
1
Aflibercept in the management of acute retinal necrosis syndrome-related macular edema. ( 28967076 )
2017
2
Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report. ( 27698716 )
2016
3
Viral encephalitis complicated by acute retinal necrosis syndrome: A case report. ( 26622338 )
2015
4
Combination Systemic and Intravitreal Antiviral Therapy in the Management of Acute Retinal Necrosis Syndrome. ( 25215870 )
2014
5
Toll like receptors and acute retinal necrosis syndrome- evaluating the association. ( 25272391 )
2014
6
Good visual outcome in an immunocompromised patient with bilateral acute retinal necrosis syndrome: A case report. ( 25278806 )
2014
7
Delayed Onset of Bilateral Acute Retinal Necrosis Syndrome: A 46-Year Interval. ( 24117381 )
2013
8
Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome (an american ophthalmological society thesis). ( 24385671 )
2013
9
Timing of prophylactic and early vitrectomy for first-presenting or recurrent acute retinal necrosis syndrome. ( 23254584 )
2012
10
Posterior scleritis resembling acute retinal necrosis syndrome. ( 25390725 )
2012
11
Efficacy and necessity of prophylactic vitrectomy for acute retinal necrosis syndrome. ( 22937510 )
2012
12
Indocyanine green angiography findings in acute retinal necrosis syndrome. ( 21484641 )
2011
13
Isolated unilateral acute retinal necrosis syndrome as the initial manifestation of HIV infection. ( 19642242 )
2009
14
Overview and diagnosis of acute retinal necrosis syndrome. ( 18584564 )
2008
15
Treatment of acute retinal necrosis syndrome with oral antiviral medications. ( 17123607 )
2007
16
Prophylactic vitrectomy in acute retinal necrosis syndrome. ( 16858447 )
2007
17
Catastrophic acute retinal necrosis syndrome associated with diffuse orbital cellulitis: a case report. ( 16628421 )
2007
18
Macular exudation as the presenting feature of acute retinal necrosis syndrome. ( 25390239 )
2007
19
Bilateral acute retinal necrosis syndrome following herpes simplex type 1 encephalitis. ( 16410814 )
2006
20
Treatment of acute retinal necrosis syndrome. ( 16969431 )
2006
21
High dosage of oral valaciclovir as an alternative treatment of varicella zoster acute retinal necrosis syndrome. ( 15776013 )
2006
22
Unilateral recurrent acute retinal necrosis syndrome caused by cytomegalovirus in an immune-competent adult. ( 16761257 )
2006
23
Necrotising retinopathies simulating acute retinal necrosis syndrome. ( 15615755 )
2005
24
Vitrectomy and silicone oil tamponade as an initial surgery for retinal detachment after acute retinal necrosis syndrome. ( 15804777 )
2005
25
Acute retinal necrosis syndrome: clinical manifestations and visual outcomes. ( 15148997 )
2004
26
Surgical treatment of retinal detachment following acute retinal necrosis syndrome: surgical results in four patients. ( 14765754 )
2003
27
Interferon gamma expression and clinical features in patients with acute retinal necrosis syndrome. ( 12928903 )
2003
28
Polymerase chain reaction as a rapid diagnostic tool for therapy of acute retinal necrosis syndrome. ( 12526051 )
2003
29
Role of viral serology in the diagnosis of acute retinal necrosis syndrome. ( 12785164 )
2002
30
Acute retinal necrosis syndrome in a child. ( 11791109 )
2002
31
Oral valacyclovir in the treatment of acute retinal necrosis syndrome. ( 12055471 )
2002
32
Herpes simplex virus type 1 encephalitis associated with acute retinal necrosis syndrome in an immunocompetent patient. ( 12390170 )
2002
33
Same eye recurrence of acute retinal necrosis syndrome. ( 11336947 )
2001
34
Retinitis syphilitica in an HIV-positive patient following acute retinal necrosis syndrome. ( 11756898 )
2001
35
Findings in a patient with herpes simplex viral meningitis associated with acute retinal necrosis syndrome. ( 11498417 )
2001
36
Herpes simplex virus type 2: a cause of acute retinal necrosis syndrome. ( 11449326 )
2001
37
Viral causes of the acute retinal necrosis syndrome. ( 11389345 )
2001
38
Herpes simplex virus type 2 as a cause of acute retinal necrosis syndrome in young patients. ( 11320015 )
2001
39
Variable R1 region in varicella zoster virus in fulminant type of acute retinal necrosis syndrome. ( 10655197 )
2000
40
Viral causes of the acute retinal necrosis syndrome. ( 10682968 )
2000
41
High prevalence of herpes simplex virus type 2 in acute retinal necrosis syndrome associated with herpes simplex virus in Japan. ( 10704570 )
2000
42
Expression of the Varicella Zoster Virus Thymidine Kinase and Cytokines in Patients with Acute Retinal Necrosis Syndrome. ( 11094200 )
2000
43
Acute retinal necrosis syndrome complicating chickenpox. ( 11296787 )
2000
44
[Expression of the varicella zoster virus thymidine kinase and cytokines in patients with acute retinal necrosis syndrome]. ( 10835891 )
2000
45
HSV-1--induced acute retinal necrosis syndrome presenting with severe inflammatory orbitopathy, proptosis, and optic nerve involvement. ( 10690844 )
2000
46
Herpes simplex encephalitis and bilateral acute retinal necrosis syndrome after craniotomy. ( 9744385 )
1998
47
[Acute retinal necrosis syndrome. Argon laser coagulation for prevention of rhegmatogenic retinal detachment]. ( 9738376 )
1998
48
Correlation of varicella-zoster virus copies and final visual acuities of acute retinal necrosis syndrome. ( 9801889 )
1998
49
Cytomegalovirus-associated acute retinal necrosis syndrome. ( 9186135 )
1997
50
Demonstration of herpes simplex virus from lens aspirate in healed acute retinal necrosis syndrome. ( 9422938 )
1997

Variations for Acute Retinal Necrosis Syndrome

Expression for Acute Retinal Necrosis Syndrome

Search GEO for disease gene expression data for Acute Retinal Necrosis Syndrome.

Pathways for Acute Retinal Necrosis Syndrome

GO Terms for Acute Retinal Necrosis Syndrome

Biological processes related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 8.62 NECTIN1 TNFRSF14

Molecular functions related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 NECTIN1 TNFRSF14

Sources for Acute Retinal Necrosis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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