Acute Retinal Necrosis Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACT022 MIFTS: 33	Acute Retinal Necrosis Syndrome Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Acute Retinal Necrosis Syndrome

MalaCards integrated aliases for Acute Retinal Necrosis Syndrome:

Name: Acute Retinal Necrosis Syndrome ¹² ¹⁵ ¹⁷

Retinal Necrosis Syndrome, Acute ⁴⁴ ⁷⁰

Acute Retinal Necrosis ¹²

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3611

MeSH ⁴⁴ D015882

SNOMED-CT ⁶⁷ 231986000

EFO ¹⁷ EFO_1000795

UMLS ⁷⁰ C0035319

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Summaries for Acute Retinal Necrosis Syndrome

MalaCards based summary : Acute Retinal Necrosis Syndrome, also known as retinal necrosis syndrome, acute, is related to chickenpox and choroiditis. An important gene associated with Acute Retinal Necrosis Syndrome is SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Anti-Infective Agents and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and lung, and related phenotype is mortality/aging.

Wikipedia : ⁷³ Acute retinal necrosis (ARN) is a medical inflammatory condition of the eye. The condition presents... more...

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Related Diseases for Acute Retinal Necrosis Syndrome

Diseases related to Acute Retinal Necrosis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 445)

#	Related Disease	Score	Top Affiliating Genes
1	chickenpox	30.2	IL6 IL10 GYPC CD8A CD4
2	choroiditis	30.1	IL10 CD4
3	cerebritis	30.1	CD8A CD4
4	herpes zoster	30.1	IL10 GYPC CD8A CD4
5	syphilis	30.0	IL6 CD8A CD4
6	acquired immunodeficiency syndrome	29.9	IL6 IL10 CD4
7	iridocyclitis	29.8	IL6 IL10 CD4
8	cytomegalovirus retinitis	29.8	IL10 GYPC CD8A CD4
9	dacryoadenitis	29.7	IL10 CD8A CD4
10	cellulitis	29.6	IL6 CD8A CD4
11	viral encephalitis	29.6	IL6 IL10 CD8A CD4
12	bacterial infectious disease	29.5	IL6 IL10 CD4
13	hypopyon	29.5	IL6 IL10 CD4
14	chorioretinitis	29.4	IL6 IL10 CD8A CD4
15	panuveitis	29.4	IL6 IL10 CD8A CD4
16	keratitis, hereditary	29.4	IL6 IL10 CD8A CD4
17	viral infectious disease	29.3	IL6 IL10 CD4
18	eye disease	29.3	IL6 IL10 CD8A CD4
19	iritis	29.2	IL6 IL10 CD8A CD4
20	meningoencephalitis	29.2	IL6 IL10 CD8A CD4
21	exanthem	29.2	IL6 IL10 CD8A CD4
22	dermatitis	29.2	IL6 IL10 CD8A CD4
23	nervous system disease	29.1	SIGLEC5 IL6 IL10 CD8A CD4
24	immune deficiency disease	29.0	SIGLEC5 IL6 IL10 CD8A CD4
25	myeloma, multiple	29.0	IL6 IL10 CD8A CD4
26	genital herpes	28.9	TNFRSF14 NECTIN1 IL10 GYPC CD8A CD4
27	disease by infectious agent	28.8	SIGLEC5 IL6 IL10 CD8A CD4
28	pulmonary fibrosis, idiopathic	28.8	SIGLEC5 IL6 IL10 CD8A CD4
29	retinal detachment	10.7
30	neuroretinitis	10.7
31	retinitis	10.7
32	herpes simplex	10.7
33	uveitis	10.5
34	retinal vasculitis	10.4
35	encephalitis	10.4
36	lymphangitis	10.3	SIGLEC5 CD4
37	pars planitis	10.3
38	vasculitis	10.3
39	retinal vascular disease	10.3
40	neuropathy	10.3
41	vitreoretinopathy, neovascular inflammatory	10.3
42	3-methylglutaconic aciduria, type iii	10.3
43	vitreoretinopathy	10.3
44	tick infestation	10.2	SIGLEC5 CD4
45	multiple sclerosis	10.2
46	blind hypotensive eye	10.2
47	branch retinal artery occlusion	10.2
48	central retinal artery occlusion	10.2
49	retinal artery occlusion	10.2
50	elephantiasis	10.2	IL10 CD4

Graphical network of the top 20 diseases related to Acute Retinal Necrosis Syndrome:

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Symptoms & Phenotypes for Acute Retinal Necrosis Syndrome

MGI Mouse Phenotypes related to Acute Retinal Necrosis Syndrome:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	9.28	CD4 CD8A HS3ST1 IL10 IL6 NECTIN1

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Drugs & Therapeutics for Acute Retinal Necrosis Syndrome

Drugs for Acute Retinal Necrosis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Anti-Infective Agents
2	Antiviral Agents

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Prophylactic Laser Photocoagulation and Vitrectomy for Acute Retinal Necrosis	Completed	NCT02222857
2	The Necessity and Optimal Time for Performing Pars Plana Vitrectomy in Acute Retinal Necrosis Patients	Completed	NCT03260049

Search NIH Clinical Center for Acute Retinal Necrosis Syndrome

Cochrane evidence based reviews: retinal necrosis syndrome, acute

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Genetic Tests for Acute Retinal Necrosis Syndrome

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Anatomical Context for Acute Retinal Necrosis Syndrome

MalaCards organs/tissues related to Acute Retinal Necrosis Syndrome:

⁴⁰

Eye, Bone, Lung, Skin, Myeloid, Retina, Bone Marrow

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Publications for Acute Retinal Necrosis Syndrome

Articles related to Acute Retinal Necrosis Syndrome:

(show top 50) (show all 176)

#	Title	Authors	PMID	Year
1	Tractional Retinal Detachment in a Patient With Waldenström's Macroglobulinemia. ⁶¹	Tsiogka A...Petrou P	33542877	2021
2	Correction to: Visual outcome and poor prognostic factors in acute retinal necrosis syndrome. ⁶¹	Mora P...Guex-Crosier Y	32840674	2021
3	Implantation of Foldable Capsular Vitreous Body for the Treatment of Acute Retinal Necrosis Syndrome: A Case Report. ⁶¹	Zhang L...Qin B	33231700	2020
4	Visual outcome and poor prognostic factors in acute retinal necrosis syndrome. ⁶¹	Paolo M...Yan GC	32328756	2020
5	Aflibercept in the management of acute retinal necrosis syndrome-related macular edema. ⁶¹	Ortega-Evangelio L...Tomas-Torrent JM	28967076	2018
6	Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report. ⁶¹	Zhou C...Fang S	27698716	2016
7	[Clinical features of viral encephalitis with bilateral acute retinal necrosis syndrome]. ⁶¹	Hou X...Jiang H	27807336	2016
8	[Role of oral antiviral therapy in the treatment of acute retinal necrosis]. ⁶¹	Haouzi SE...Daoudi R	27795766	2016
9	Viral encephalitis complicated by acute retinal necrosis syndrome: A case report. ⁶¹	Liang ZG...Yu GP	26622338	2015
10	Delayed onset of bilateral acute retinal necrosis syndrome: a 46-year interval. ⁶¹	La Cava M...Zito R	24117381	2015
11	Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome. ⁶¹	Yeh S...Flaxel CJ	25215870	2014
12	Toll like receptors and acute retinal necrosis syndrome- evaluating the association. ⁶¹	Pathak S	25272391	2014
13	Good visual outcome in an immunocompromised patient with bilateral acute retinal necrosis syndrome: A case report. ⁶¹	Marrocos de Aragao RE...Ramos CS	25278806	2014
14	Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome (an American Ophthalmological Society thesis). ⁶¹	Flaxel CJ...Lauer AK	24385671	2013
15	[Factors associated with visual prognosis of acute retinal necrosis syndrome]. ⁶¹	Wen X...Zhao C	23866700	2013
16	Posterior scleritis resembling acute retinal necrosis syndrome. ⁶¹	Badal J...Garcia-Arumi J	25390725	2012
17	Efficacy and necessity of prophylactic vitrectomy for acute retinal necrosis syndrome. ⁶¹	Luo YH...Guo XJ	22937510	2012
18	Timing of prophylactic and early vitrectomy for first-presenting or recurrent acute retinal necrosis syndrome. ⁶¹	Matsuo T	23254584	2012
19	Indocyanine green angiography findings in acute retinal necrosis syndrome. ⁶¹	Bissig A...Guex-Crosier Y	21484641	2011
20	Kyrieleis plaques associated with acute retinal necrosis from herpes simplex virus type 2. ⁶¹	Witmer MT...Madow B	25390418	2011
21	Unilateral acute retinal necrosis in a multiple sclerosis patient treated with high-dose systemic steroids. ⁶¹	Saatci AO...Ada E	20524142	2010
22	[Pars plana vitrectomy in patients with acute retinal necrosis syndrome: surgical results in 52 patients]. ⁶¹	Usui Y...Goto H	20432961	2010
23	[Acute retinal necrosis]. ⁶¹	Gandorfer A...Thurau S	19693512	2009
24	Isolated unilateral acute retinal necrosis syndrome as the initial manifestation of HIV infection. ⁶¹	Gharai S...Vohra R	19642242	2009
25	[Management of acute retinal necrosis syndrome with cystoid macular edema: a case report]. ⁶¹	Izambart C...Gastaud P	19515316	2009
26	Herpetic encephalitis is a risk factor for acute retinal necrosis. ⁶¹	Vandercam T...Van der Lelij A	18852442	2008
27	Overview and diagnosis of acute retinal necrosis syndrome. ⁶¹	Usui Y...Goto H	18584564	2008
28	Epstein-Barr virus and acute retinal necrosis in a 5-year-old immunocompetent child. ⁶¹	Gallego-Pinazo R...Pinazo-Duran MD	19668736	2008
29	[Retinal manifestations of infectious diseases]. ⁶¹	Perez de Arcelus M...Garcia Layana A	19169295	2008
30	Three consecutive episodes of acute retinal necrosis due to herpes simplex-1 over twelve years following herpetic encephalitis. ⁶¹	Klein A...Lefebvre P	17972228	2007
31	[Acute retinal necrosis syndrome following chickenpox]. ⁶¹	Bolivar G...Pareja J	17846952	2007
32	Treatment of acute retinal necrosis syndrome with oral antiviral medications. ⁶¹	Aizman A...Elner SG	17123607	2007
33	[Acute retinal necrosis syndrome]. ⁶¹	Branisteanu D...Medvichi R	18543676	2007
34	Catastrophic acute retinal necrosis syndrome associated with diffuse orbital cellulitis: a case report. ⁶¹	Rozenbaum O...Bodaghi B	16628421	2007
35	Macular exudation as the presenting feature of acute retinal necrosis syndrome. ⁶¹	Minamoto A...Mishima HK	25390239	2007
36	Prophylactic vitrectomy in acute retinal necrosis syndrome. ⁶¹	Berker N...Soykan E	16858447	2007
37	Bilateral acute retinal necrosis syndrome following herpes simplex type 1 encephalitis. ⁶¹	Bristow EA...Pandit RJ	16410814	2006
38	Treatment of acute retinal necrosis syndrome. ⁶¹	Aizman A	16969431	2006
39	Unilateral recurrent acute retinal necrosis syndrome caused by cytomegalovirus in an immune-competent adult. ⁶¹	Voros GM...Griffiths PG	16761257	2006
40	Ocular herpes simplex: changing epidemiology, emerging disease patterns, and the potential of vaccine prevention and therapy. ⁶¹	Pepose JS...Morrison LA	16490506	2006
41	High dosage of oral valaciclovir as an alternative treatment of varicella zoster acute retinal necrosis syndrome. ⁶¹	Guex-Crosier Y...Meylan PR	15776013	2006
42	Vitrectomy and silicone oil tamponade as an initial surgery for retinal detachment after acute retinal necrosis syndrome. ⁶¹	Matsuo T	15804777	2005
43	Necrotising retinopathies simulating acute retinal necrosis syndrome. ⁶¹	Balansard B...Lehoang P	15615755	2005
44	[Bilateral acute retinal necrosis syndrome associated with meningoencephalitis caused by herpes simplex virus 2. A case report]. ⁶¹	Cardine S...Benzacken L	15499278	2004
45	[Necrotic herpetic retinitis]. ⁶¹	Fardeau C	15179313	2004
46	Clinical characteristics of acute HSV-2 retinal necrosis. ⁶¹	Tran TH...Bodaghi B	15126152	2004
47	Acute retinal necrosis syndrome: clinical manifestations and visual outcomes. ⁶¹	Chen HP...Kao ML	15148997	2004
48	Interferon gamma expression and clinical features in patients with acute retinal necrosis syndrome. ⁶¹	Abe T...Tamai M	12928903	2003
49	Surgical treatment of retinal detachment following acute retinal necrosis syndrome: surgical results in four patients. ⁶¹	Hou CH...Ho CL	14765754	2003
50	[Brivudine as an alternative systemic therapy to aciclovir and ganciclovir in acute retinal necrosis syndrome due to varicella-zoster virus]. ⁶¹	Vij O...Schilling H	14577039	2003

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Genes for Acute Retinal Necrosis Syndrome

Genes related to Acute Retinal Necrosis Syndrome (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SIGLEC5	Sialic Acid Binding Ig Like Lectin 5	Protein Coding	7.31	DISEASES inferred ¹⁵ ¹⁵
2	TGIF1	TGFB Induced Factor Homeobox 1	Protein Coding	6.85	GeneCards inferred via : Publications (show sections)
3	CD4	CD4 Molecule	Protein Coding	6.58	DISEASES inferred ¹⁵
4	NECTIN1	Nectin Cell Adhesion Molecule 1	Protein Coding	5.84	DISEASES inferred ¹⁵
5	GYPC	Glycophorin C (Gerbich Blood Group)	Protein Coding	5.53	DISEASES inferred ¹⁵
6	UST	Uronyl 2-Sulfotransferase	Protein Coding	5.52	DISEASES inferred ¹⁵
7	TNFRSF14	TNF Receptor Superfamily Member 14	Protein Coding	5.5	DISEASES inferred ¹⁵
8	CD8A	CD8a Molecule	Protein Coding	5.35	DISEASES inferred ¹⁵
9	HS3ST1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 1	Protein Coding	5.25	DISEASES inferred ¹⁵
10	IL6	Interleukin 6	Protein Coding	5.17	DISEASES inferred ¹⁵
11	IL10	Interleukin 10	Protein Coding	4.99	DISEASES inferred ¹⁵

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Variations for Acute Retinal Necrosis Syndrome

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Expression for Acute Retinal Necrosis Syndrome

Search GEO for disease gene expression data for Acute Retinal Necrosis Syndrome.

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Pathways for Acute Retinal Necrosis Syndrome

Pathways related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.98	TNFRSF14 NECTIN1 IL6 IL10 CD4
2	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.54	IL6 IL10 CD8A CD4
3	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.3	IL6 IL10 CD8A CD4
4	Cell adhesion molecules ³⁶	11.83	NECTIN1 CD8A CD4
5	Yersinia infection ³⁶	11.69	IL6 IL10 CD8A CD4
6	Hematopoietic cell lineage ³⁶	11.6	IL6 CD8A CD4
7	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.48	IL10 CD8A CD4
8	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.43	IL6 IL10 CD4
9	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.32	IL6 IL10 CD8A CD4
10	Malaria ³⁶	11.2	IL6 IL10 GYPC
11	Cytokines and Inflammatory Response ¹	10.79	IL6 IL10 CD4
12	Dendritic Cells Developmental Lineage Pathway ⁶⁴	10.79	IL6 IL10 CD8A CD4

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GO Terms for Acute Retinal Necrosis Syndrome

Biological processes related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.33	TNFRSF14 IL6 CD4
2	positive regulation of immunoglobulin production	GO:0002639	9.26	IL6 IL10
3	defense response to Gram-negative bacterium	GO:0050829	9.13	TNFRSF14 IL6 CD4
4	immune response	GO:0006955	9.1	TNFRSF14 NECTIN1 IL6 IL10 CD8A CD4

Molecular functions related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	virus receptor activity	GO:0001618	9.13	TNFRSF14 NECTIN1 CD4
2	coreceptor activity	GO:0015026	8.8	NECTIN1 CD8A CD4

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Sources for Acute Retinal Necrosis Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia