MCID: ACT022
MIFTS: 30

Acute Retinal Necrosis Syndrome

Categories: Neuronal diseases

Aliases & Classifications for Acute Retinal Necrosis Syndrome

MalaCards integrated aliases for Acute Retinal Necrosis Syndrome:

Name: Acute Retinal Necrosis Syndrome 12 15 17
Retinal Necrosis Syndrome, Acute 43 71
Acute Retinal Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3611
MeSH 43 D015882
SNOMED-CT 67 231986000
UMLS 71 C0035319

Summaries for Acute Retinal Necrosis Syndrome

MalaCards based summary : Acute Retinal Necrosis Syndrome, also known as retinal necrosis syndrome, acute, is related to neuroretinitis and retinal vasculitis. An important gene associated with Acute Retinal Necrosis Syndrome is SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5), and among its related pathways/superpathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Cell adhesion molecules (CAMs). The drugs Antiviral Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related phenotype is homeostasis/metabolism.

Wikipedia : 74 Acute Retinal Necrosis (ARN), is a medical inflammatory condition of the eye. The condition presents... more...

Related Diseases for Acute Retinal Necrosis Syndrome

Diseases related to Acute Retinal Necrosis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 400)
# Related Disease Score Top Affiliating Genes
1 neuroretinitis 31.2 MRAP CD40LG CD4
2 retinal vasculitis 30.7 MRAP CD40LG CD4
3 chickenpox 30.3 GYPC CD8A CD40LG CD4
4 optic papillitis 30.3 MRAP CD40LG CD4
5 asymptomatic neurosyphilis 30.3 CD40LG CD4
6 pustulosis of palm and sole 30.3 SIGLEC5 MRAP
7 cranial nerve palsy 30.2 CD40LG CD4
8 choroiditis 30.1 MRAP CD40LG CD4
9 endophthalmitis 29.9 MRAP CD4 ASPRV1
10 herpes simplex 29.9 TNFRSF14 NECTIN1 GYPC CD8A
11 hypopyon 29.9 MRAP CD4 ASPRV1
12 viral encephalitis 29.8 CD8A CD40LG CD4
13 iridocyclitis 29.8 MRAP CD40LG CD4 ASPRV1
14 optic nerve disease 29.8 CD8A CD40LG CD4
15 dacryoadenitis 29.7 CD8A CD4
16 herpes zoster 29.6 GYPC CD8A CD40LG CD4
17 syphilis 29.5 MRAP CD8A CD40LG CD4
18 exanthem 29.5 CD8A CD40LG CD4
19 meningoencephalitis 29.5 CD8A CD40LG CD4
20 cellulitis 29.5 CD8A CD40LG CD4
21 cerebritis 29.4 CD8A CD40LG CD4
22 bacterial infectious disease 29.4 CD8A CD40LG CD4
23 sarcoidosis 1 29.4 MRAP CD8A CD40LG CD4
24 progressive multifocal leukoencephalopathy 29.4 CD8A CD40LG CD4
25 chorioretinitis 29.4 MRAP CD8A CD40LG CD4
26 panuveitis 29.4 MRAP CD8A CD40LG CD4
27 pfeiffer syndrome 29.4 CD8A CD40LG CD4
28 cytomegalovirus retinitis 29.3 GYPC CD8A CD40LG CD4
29 iritis 29.2 MRAP CD8A CD40LG CD4
30 eye disease 29.2 MRAP CD8A CD40LG CD4
31 genital herpes 28.0 TNFRSF14 NECTIN1 GYPC CD8A CD40LG CD4
32 retinal detachment 10.6
33 retinitis 10.6
34 ocular tuberculosis 10.4 MRAP CD4
35 american histoplasmosis 10.4 CD40LG CD4
36 syphilitic meningitis 10.4 CD40LG CD4
37 uveitis 10.4
38 latent syphilis 10.4 CD40LG CD4
39 gastroduodenitis 10.4 CD40LG CD4
40 primary syphilis 10.4 CD40LG CD4
41 necrotizing ulcerative gingivitis 10.4 CD40LG CD4
42 chorioretinal scar 10.4 SIGLEC5 CD40LG
43 tertiary neurosyphilis 10.4 CD40LG CD4
44 epiglottitis 10.4 SIGLEC5 CD40LG
45 bacillary angiomatosis 10.4 CD40LG CD4
46 meningovascular neurosyphilis 10.4 CD40LG CD4
47 opportunistic bacterial infectious disease 10.4 CD40LG CD4
48 chronic orbital inflammation 10.4 MRAP CD40LG
49 subacute bacterial endocarditis 10.4 SIGLEC5 CD40LG
50 cerebral lymphoma 10.4 CD40LG CD4

Graphical network of the top 20 diseases related to Acute Retinal Necrosis Syndrome:



Diseases related to Acute Retinal Necrosis Syndrome

Symptoms & Phenotypes for Acute Retinal Necrosis Syndrome

MGI Mouse Phenotypes related to Acute Retinal Necrosis Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 ARNT CD4 CD40LG GYPC HS3ST1 MRAP

Drugs & Therapeutics for Acute Retinal Necrosis Syndrome

Drugs for Acute Retinal Necrosis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antiviral Agents
2 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Necessity and Optimal Time for Performing Pars Plana Vitrectomy in Acute Retinal Necrosis Patients Completed NCT03260049
2 Prophylactic Laser Photocoagulation and Vitrectomy for Acute Retinal Necrosis Completed NCT02222857

Search NIH Clinical Center for Acute Retinal Necrosis Syndrome

Cochrane evidence based reviews: retinal necrosis syndrome, acute

Genetic Tests for Acute Retinal Necrosis Syndrome

Anatomical Context for Acute Retinal Necrosis Syndrome

MalaCards organs/tissues related to Acute Retinal Necrosis Syndrome:

40
Eye, Retina

Publications for Acute Retinal Necrosis Syndrome

Articles related to Acute Retinal Necrosis Syndrome:

(show top 50) (show all 173)
# Title Authors PMID Year
1
Visual outcome and poor prognostic factors in acute retinal necrosis syndrome. 61
32328756 2020
2
Aflibercept in the management of acute retinal necrosis syndrome-related macular edema. 61
28967076 2018
3
Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report. 61
27698716 2016
4
[Clinical features of viral encephalitis with bilateral acute retinal necrosis syndrome]. 61
27807336 2016
5
[Role of oral antiviral therapy in the treatment of acute retinal necrosis]. 61
27795766 2016
6
Viral encephalitis complicated by acute retinal necrosis syndrome: A case report. 61
26622338 2015
7
Delayed onset of bilateral acute retinal necrosis syndrome: a 46-year interval. 61
24117381 2015
8
Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome. 61
25215870 2014
9
Good visual outcome in an immunocompromised patient with bilateral acute retinal necrosis syndrome: A case report. 61
25278806 2014
10
Toll like receptors and acute retinal necrosis syndrome- evaluating the association. 61
25272391 2014
11
Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome (an American Ophthalmological Society thesis). 61
24385671 2013
12
[Factors associated with visual prognosis of acute retinal necrosis syndrome]. 61
23866700 2013
13
Efficacy and necessity of prophylactic vitrectomy for acute retinal necrosis syndrome. 61
22937510 2012
14
Posterior scleritis resembling acute retinal necrosis syndrome. 61
25390725 2012
15
Timing of prophylactic and early vitrectomy for first-presenting or recurrent acute retinal necrosis syndrome. 61
23254584 2012
16
Indocyanine green angiography findings in acute retinal necrosis syndrome. 61
21484641 2011
17
Kyrieleis plaques associated with acute retinal necrosis from herpes simplex virus type 2. 61
25390418 2011
18
Unilateral acute retinal necrosis in a multiple sclerosis patient treated with high-dose systemic steroids. 61
20524142 2010
19
[Pars plana vitrectomy in patients with acute retinal necrosis syndrome: surgical results in 52 patients]. 61
20432961 2010
20
[Acute retinal necrosis]. 61
19693512 2009
21
Isolated unilateral acute retinal necrosis syndrome as the initial manifestation of HIV infection. 61
19642242 2009
22
[Management of acute retinal necrosis syndrome with cystoid macular edema: a case report]. 61
19515316 2009
23
Herpetic encephalitis is a risk factor for acute retinal necrosis. 61
18852442 2008
24
Overview and diagnosis of acute retinal necrosis syndrome. 61
18584564 2008
25
Epstein-Barr virus and acute retinal necrosis in a 5-year-old immunocompetent child. 61
19668736 2008
26
[Retinal manifestations of infectious diseases]. 61
19169295 2008
27
[Acute retinal necrosis syndrome following chickenpox]. 61
17846952 2007
28
Three consecutive episodes of acute retinal necrosis due to herpes simplex-1 over twelve years following herpetic encephalitis. 61
17972228 2007
29
Treatment of acute retinal necrosis syndrome with oral antiviral medications. 61
17123607 2007
30
[Acute retinal necrosis syndrome]. 61
18543676 2007
31
Catastrophic acute retinal necrosis syndrome associated with diffuse orbital cellulitis: a case report. 61
16628421 2007
32
Prophylactic vitrectomy in acute retinal necrosis syndrome. 61
16858447 2007
33
Macular exudation as the presenting feature of acute retinal necrosis syndrome. 61
25390239 2007
34
Bilateral acute retinal necrosis syndrome following herpes simplex type 1 encephalitis. 61
16410814 2006
35
Treatment of acute retinal necrosis syndrome. 61
16969431 2006
36
Unilateral recurrent acute retinal necrosis syndrome caused by cytomegalovirus in an immune-competent adult. 61
16761257 2006
37
Ocular herpes simplex: changing epidemiology, emerging disease patterns, and the potential of vaccine prevention and therapy. 61
16490506 2006
38
High dosage of oral valaciclovir as an alternative treatment of varicella zoster acute retinal necrosis syndrome. 61
15776013 2006
39
Vitrectomy and silicone oil tamponade as an initial surgery for retinal detachment after acute retinal necrosis syndrome. 61
15804777 2005
40
Necrotising retinopathies simulating acute retinal necrosis syndrome. 61
15615755 2005
41
[Bilateral acute retinal necrosis syndrome associated with meningoencephalitis caused by herpes simplex virus 2. A case report]. 61
15499278 2004
42
Clinical characteristics of acute HSV-2 retinal necrosis. 61
15126152 2004
43
[Necrotic herpetic retinitis]. 61
15179313 2004
44
Acute retinal necrosis syndrome: clinical manifestations and visual outcomes. 61
15148997 2004
45
Interferon gamma expression and clinical features in patients with acute retinal necrosis syndrome. 61
12928903 2003
46
Surgical treatment of retinal detachment following acute retinal necrosis syndrome: surgical results in four patients. 61
14765754 2003
47
[Toxoplasma gondii and necrotizing retinitis: a case report]. 61
14586227 2003
48
[Brivudine as an alternative systemic therapy to aciclovir and ganciclovir in acute retinal necrosis syndrome due to varicella-zoster virus]. 61
14577039 2003
49
Acute retinal necrosis following epidural steroid injections. 61
12834695 2003
50
Polymerase chain reaction as a rapid diagnostic tool for therapy of acute retinal necrosis syndrome. 61
12526051 2003

Variations for Acute Retinal Necrosis Syndrome

Expression for Acute Retinal Necrosis Syndrome

Search GEO for disease gene expression data for Acute Retinal Necrosis Syndrome.

Pathways for Acute Retinal Necrosis Syndrome

Pathways related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 SIGLEC5 CD8A CD40LG
2 11.09 NECTIN1 CD8A CD40LG CD4
3 10.71 CD8A CD40LG CD4

GO Terms for Acute Retinal Necrosis Syndrome

Cellular components related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 TNFRSF14 CD8A CD40LG CD4

Biological processes related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.02 TNFRSF14 NECTIN1 CD8A CD40LG CD4

Molecular functions related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.13 TNFRSF14 NECTIN1 CD4
2 coreceptor activity GO:0015026 8.8 NECTIN1 CD8A CD4

Sources for Acute Retinal Necrosis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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