MCID: ACT022
MIFTS: 32

Acute Retinal Necrosis Syndrome

Categories: Neuronal diseases

Aliases & Classifications for Acute Retinal Necrosis Syndrome

MalaCards integrated aliases for Acute Retinal Necrosis Syndrome:

Name: Acute Retinal Necrosis Syndrome 12 15 17
Retinal Necrosis Syndrome, Acute 44 71
Acute Retinal Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3611
MeSH 44 D015882
SNOMED-CT 67 231986000
UMLS 71 C0035319

Summaries for Acute Retinal Necrosis Syndrome

MalaCards based summary : Acute Retinal Necrosis Syndrome, also known as retinal necrosis syndrome, acute, is related to chickenpox and choroiditis. An important gene associated with Acute Retinal Necrosis Syndrome is SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Anti-Infective Agents and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related phenotype is mortality/aging.

Wikipedia : 74 Acute retinal necrosis (ARN) is a medical inflammatory condition of the eye. The condition presents... more...

Related Diseases for Acute Retinal Necrosis Syndrome

Diseases related to Acute Retinal Necrosis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 443)
# Related Disease Score Top Affiliating Genes
1 chickenpox 30.2 IL6 IL10 GYPC CD8A CD4
2 choroiditis 30.1 IL10 CD4
3 cerebritis 30.1 CD8A CD4
4 herpes zoster 30.1 IL10 GYPC CD8A CD4
5 acquired immunodeficiency syndrome 29.9 IL6 IL10 CD4
6 cytomegalovirus retinitis 29.8 IL10 GYPC CD8A CD4
7 dacryoadenitis 29.7 IL10 CD8A CD4
8 cellulitis 29.6 IL6 CD8A CD4
9 viral encephalitis 29.5 IL6 IL10 CD8A CD4
10 bacterial infectious disease 29.5 IL6 IL10 CD4
11 hypopyon 29.5 IL6 IL10 CD4
12 iridocyclitis 29.4 IL6 IL10 CD8A CD4
13 chorioretinitis 29.4 IL6 IL10 CD8A CD4
14 panuveitis 29.4 IL6 IL10 CD8A CD4
15 keratitis, hereditary 29.4 IL6 IL10 CD8A CD4
16 viral infectious disease 29.3 IL6 IL10 CD4
17 eye disease 29.3 IL6 IL10 CD8A CD4
18 genital herpes 29.2 TNFRSF14 NECTIN1 IL10 CD8A CD4
19 iritis 29.2 IL6 IL10 CD8A CD4
20 meningoencephalitis 29.2 IL6 IL10 CD8A CD4
21 exanthem 29.2 IL6 IL10 CD8A CD4
22 dermatitis 29.2 IL6 IL10 CD8A CD4
23 nervous system disease 29.1 SIGLEC5 IL6 IL10 CD8A CD4
24 immune deficiency disease 29.0 SIGLEC5 IL6 IL10 CD8A CD4
25 myeloma, multiple 29.0 IL6 IL10 CD8A CD4
26 crohn's disease 29.0 IL6 IL10 CD4
27 disease by infectious agent 28.8 SIGLEC5 IL6 IL10 CD8A CD4
28 pulmonary fibrosis, idiopathic 28.8 SIGLEC5 IL6 IL10 CD8A CD4
29 retinal detachment 10.7
30 neuroretinitis 10.7
31 retinitis 10.7
32 herpes simplex 10.7
33 uveitis 10.5
34 retinal vasculitis 10.4
35 encephalitis 10.4
36 vasculitis 10.3
37 pars planitis 10.3
38 lymphangitis 10.3 SIGLEC5 CD4
39 retinal vascular disease 10.3
40 neuropathy 10.3
41 vitreoretinopathy, neovascular inflammatory 10.3
42 3-methylglutaconic aciduria, type iii 10.3
43 vitreoretinopathy 10.3
44 tick infestation 10.2 SIGLEC5 CD4
45 blind hypotensive eye 10.2
46 branch retinal artery occlusion 10.2
47 central retinal artery occlusion 10.2
48 retinal artery occlusion 10.2
49 elephantiasis 10.2 IL10 CD4
50 cork-handlers' disease 10.2 CD8A CD4

Graphical network of the top 20 diseases related to Acute Retinal Necrosis Syndrome:



Diseases related to Acute Retinal Necrosis Syndrome

Symptoms & Phenotypes for Acute Retinal Necrosis Syndrome

MGI Mouse Phenotypes related to Acute Retinal Necrosis Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.28 CD4 CD8A HS3ST1 IL10 IL6 NECTIN1

Drugs & Therapeutics for Acute Retinal Necrosis Syndrome

Drugs for Acute Retinal Necrosis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents
2 Antiviral Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Necessity and Optimal Time for Performing Pars Plana Vitrectomy in Acute Retinal Necrosis Patients Completed NCT03260049
2 Prophylactic Laser Photocoagulation and Vitrectomy for Acute Retinal Necrosis Completed NCT02222857

Search NIH Clinical Center for Acute Retinal Necrosis Syndrome

Cochrane evidence based reviews: retinal necrosis syndrome, acute

Genetic Tests for Acute Retinal Necrosis Syndrome

Anatomical Context for Acute Retinal Necrosis Syndrome

MalaCards organs/tissues related to Acute Retinal Necrosis Syndrome:

40
Eye, Retina

Publications for Acute Retinal Necrosis Syndrome

Articles related to Acute Retinal Necrosis Syndrome:

(show top 50) (show all 175)
# Title Authors PMID Year
1
Tractional Retinal Detachment in a Patient With Waldenström's Macroglobulinemia. 61
33542877 2021
2
Correction to: Visual outcome and poor prognostic factors in acute retinal necrosis syndrome. 61
32840674 2021
3
Implantation of Foldable Capsular Vitreous Body for the Treatment of Acute Retinal Necrosis Syndrome: A Case Report. 61
33231700 2020
4
Visual outcome and poor prognostic factors in acute retinal necrosis syndrome. 61
32328756 2020
5
Aflibercept in the management of acute retinal necrosis syndrome-related macular edema. 61
28967076 2018
6
[Clinical features of viral encephalitis with bilateral acute retinal necrosis syndrome]. 61
27807336 2016
7
Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report. 61
27698716 2016
8
[Role of oral antiviral therapy in the treatment of acute retinal necrosis]. 61
27795766 2016
9
Viral encephalitis complicated by acute retinal necrosis syndrome: A case report. 61
26622338 2015
10
Delayed onset of bilateral acute retinal necrosis syndrome: a 46-year interval. 61
24117381 2015
11
Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome. 61
25215870 2014
12
Good visual outcome in an immunocompromised patient with bilateral acute retinal necrosis syndrome: A case report. 61
25278806 2014
13
Toll like receptors and acute retinal necrosis syndrome- evaluating the association. 61
25272391 2014
14
Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome (an American Ophthalmological Society thesis). 61
24385671 2013
15
[Factors associated with visual prognosis of acute retinal necrosis syndrome]. 61
23866700 2013
16
Posterior scleritis resembling acute retinal necrosis syndrome. 61
25390725 2012
17
Efficacy and necessity of prophylactic vitrectomy for acute retinal necrosis syndrome. 61
22937510 2012
18
Timing of prophylactic and early vitrectomy for first-presenting or recurrent acute retinal necrosis syndrome. 61
23254584 2012
19
Indocyanine green angiography findings in acute retinal necrosis syndrome. 61
21484641 2011
20
Kyrieleis plaques associated with acute retinal necrosis from herpes simplex virus type 2. 61
25390418 2011
21
Unilateral acute retinal necrosis in a multiple sclerosis patient treated with high-dose systemic steroids. 61
20524142 2010
22
[Pars plana vitrectomy in patients with acute retinal necrosis syndrome: surgical results in 52 patients]. 61
20432961 2010
23
[Acute retinal necrosis]. 61
19693512 2009
24
Isolated unilateral acute retinal necrosis syndrome as the initial manifestation of HIV infection. 61
19642242 2009
25
[Management of acute retinal necrosis syndrome with cystoid macular edema: a case report]. 61
19515316 2009
26
Herpetic encephalitis is a risk factor for acute retinal necrosis. 61
18852442 2008
27
Overview and diagnosis of acute retinal necrosis syndrome. 61
18584564 2008
28
Epstein-Barr virus and acute retinal necrosis in a 5-year-old immunocompetent child. 61
19668736 2008
29
[Retinal manifestations of infectious diseases]. 61
19169295 2008
30
Three consecutive episodes of acute retinal necrosis due to herpes simplex-1 over twelve years following herpetic encephalitis. 61
17972228 2007
31
[Acute retinal necrosis syndrome following chickenpox]. 61
17846952 2007
32
Treatment of acute retinal necrosis syndrome with oral antiviral medications. 61
17123607 2007
33
[Acute retinal necrosis syndrome]. 61
18543676 2007
34
Catastrophic acute retinal necrosis syndrome associated with diffuse orbital cellulitis: a case report. 61
16628421 2007
35
Prophylactic vitrectomy in acute retinal necrosis syndrome. 61
16858447 2007
36
Macular exudation as the presenting feature of acute retinal necrosis syndrome. 61
25390239 2007
37
Bilateral acute retinal necrosis syndrome following herpes simplex type 1 encephalitis. 61
16410814 2006
38
Treatment of acute retinal necrosis syndrome. 61
16969431 2006
39
Unilateral recurrent acute retinal necrosis syndrome caused by cytomegalovirus in an immune-competent adult. 61
16761257 2006
40
Ocular herpes simplex: changing epidemiology, emerging disease patterns, and the potential of vaccine prevention and therapy. 61
16490506 2006
41
High dosage of oral valaciclovir as an alternative treatment of varicella zoster acute retinal necrosis syndrome. 61
15776013 2006
42
Vitrectomy and silicone oil tamponade as an initial surgery for retinal detachment after acute retinal necrosis syndrome. 61
15804777 2005
43
Necrotising retinopathies simulating acute retinal necrosis syndrome. 61
15615755 2005
44
[Bilateral acute retinal necrosis syndrome associated with meningoencephalitis caused by herpes simplex virus 2. A case report]. 61
15499278 2004
45
[Necrotic herpetic retinitis]. 61
15179313 2004
46
Clinical characteristics of acute HSV-2 retinal necrosis. 61
15126152 2004
47
Acute retinal necrosis syndrome: clinical manifestations and visual outcomes. 61
15148997 2004
48
Interferon gamma expression and clinical features in patients with acute retinal necrosis syndrome. 61
12928903 2003
49
Surgical treatment of retinal detachment following acute retinal necrosis syndrome: surgical results in four patients. 61
14765754 2003
50
[Brivudine as an alternative systemic therapy to aciclovir and ganciclovir in acute retinal necrosis syndrome due to varicella-zoster virus]. 61
14577039 2003

Variations for Acute Retinal Necrosis Syndrome

Expression for Acute Retinal Necrosis Syndrome

Search GEO for disease gene expression data for Acute Retinal Necrosis Syndrome.

Pathways for Acute Retinal Necrosis Syndrome

Pathways related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 TNFRSF14 NECTIN1 IL6 IL10 CD4
2
Show member pathways
12.54 IL6 IL10 CD8A CD4
3
Show member pathways
12.3 IL6 IL10 CD8A CD4
4 11.83 NECTIN1 CD8A CD4
5 11.69 IL6 IL10 CD8A CD4
6 11.6 IL6 CD8A CD4
7 11.48 IL10 CD8A CD4
8
Show member pathways
11.43 IL6 IL10 CD4
9 11.32 IL6 IL10 CD8A CD4
10 11.2 IL6 IL10 GYPC
11 10.79 IL6 IL10 CD4
12 10.79 IL6 IL10 CD8A CD4

GO Terms for Acute Retinal Necrosis Syndrome

Biological processes related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.33 TNFRSF14 IL6 CD4
2 positive regulation of immunoglobulin production GO:0002639 9.26 IL6 IL10
3 defense response to Gram-negative bacterium GO:0050829 9.13 TNFRSF14 IL6 CD4
4 immune response GO:0006955 9.1 TNFRSF14 NECTIN1 IL6 IL10 CD8A CD4

Molecular functions related to Acute Retinal Necrosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.13 TNFRSF14 NECTIN1 CD4
2 coreceptor activity GO:0015026 8.8 NECTIN1 CD8A CD4

Sources for Acute Retinal Necrosis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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