MCID: ACT038
MIFTS: 30

Acute Retrobulbar Neuritis

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Acute Retrobulbar Neuritis

MalaCards integrated aliases for Acute Retrobulbar Neuritis:

Name: Acute Retrobulbar Neuritis 12 15 73
Retrobulbar Neuritis 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14155
ICD9CM 35 377.32
SNOMED-CT 68 51604006
ICD10 33 H48.1

Summaries for Acute Retrobulbar Neuritis

MalaCards based summary : Acute Retrobulbar Neuritis, also known as retrobulbar neuritis, is related to optic nerve disease and optic neuritis. An important gene associated with Acute Retrobulbar Neuritis is DNAI2 (Dynein Axonemal Intermediate Chain 2). Affiliated tissues include eye, brain and kidney, and related phenotype is growth/size/body region.

Related Diseases for Acute Retrobulbar Neuritis

Diseases related to Acute Retrobulbar Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 29.4 EDN1 MBP MT-ND4 UBL4A
2 optic neuritis 11.4
3 neuritis 10.5
4 3-methylglutaconic aciduria, type iii 10.2
5 sparganosis 10.2 MT-CYB MT-ND4
6 leber optic atrophy 10.2 MT-CYB MT-ND4
7 scotoma 10.1
8 carrion's disease 10.1 MT-CYB MT-ND4
9 herpes zoster 10.1
10 herpes zoster ophthalmicus 10.1
11 xerophthalmia 10.1 RHO TRIM21
12 tritanopia 10.1 MT-ND4 RHO
13 pernicious anemia 10.1
14 malaria 10.1
15 mumps 10.1
16 hemiplegia 10.1
17 uveitis 10.1
18 cluster headache 10.1
19 headache 10.1
20 optic disk drusen 10.0 RHO UBL4A
21 tertiary neurosyphilis 10.0 MBP MYH9
22 cranial nerve disease 10.0 MBP MT-ND4 UBL4A
23 retinitis pigmentosa 7 10.0 B2M RHO
24 multiple sclerosis 10.0
25 sinusitis 10.0
26 low tension glaucoma 9.9 EDN1 RHO
27 atrial standstill 1 9.9
28 retinal detachment 9.9
29 factor xii deficiency 9.9
30 myeloma, multiple 9.9
31 hereditary ataxia 9.9
32 lymphoma 9.9
33 optic papillitis 9.9
34 osteomyelitis 9.9
35 meningoencephalitis 9.9
36 rabies 9.9
37 choroiditis 9.9
38 nutritional optic neuropathy 9.9
39 arachnoiditis 9.9
40 guillain-barre syndrome 9.9
41 neurilemmoma 9.9
42 syringomyelia 9.9
43 plasmacytoma 9.9
44 chiasmal syndrome 9.9
45 acquired immunodeficiency syndrome 9.9
46 hyperthyroidism 9.9
47 measles 9.9
48 neuropathy 9.9
49 viral infectious disease 9.9
50 meningitis 9.9

Graphical network of the top 20 diseases related to Acute Retrobulbar Neuritis:



Diseases related to Acute Retrobulbar Neuritis

Symptoms & Phenotypes for Acute Retrobulbar Neuritis

MGI Mouse Phenotypes related to Acute Retrobulbar Neuritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.32 B2M DNAI1 DNAI2 DNAJB6 EDN1 FANCB

Drugs & Therapeutics for Acute Retrobulbar Neuritis

Search Clinical Trials , NIH Clinical Center for Acute Retrobulbar Neuritis

Genetic Tests for Acute Retrobulbar Neuritis

Anatomical Context for Acute Retrobulbar Neuritis

MalaCards organs/tissues related to Acute Retrobulbar Neuritis:

41
Eye, Brain, Kidney, Testes, T Cells

Publications for Acute Retrobulbar Neuritis

Articles related to Acute Retrobulbar Neuritis:

(show top 50) (show all 136)
# Title Authors Year
1
The correlation of changes of the optic nerve diameter in the acute retrobulbar neuritis with the brain changes in multiple sclerosis. ( 16417174 )
2005
2
Bilateral retrobulbar neuritis associated with mumps. ( 15814053 )
2005
3
Diagnostic and therapeutic doubts in retrobulbar neuritis in children. ( 16193696 )
2005
4
Falciparum malaria induced retrobulbar neuritis. ( 15235217 )
2004
5
Retrobulbar neuritis following rabies vaccination. ( 15267054 )
2004
6
Retrobulbar neuritis associated with Borrelia afzelii infection. ( 12061028 )
2002
7
Acute asymmetric upper nasal quandrantanopsia caused by a chiasmal colloid cyst in a patient with multiple sclerosis and bilateral retrobulbar neuritis. ( 11476707 )
2001
8
Multiple sclerosis with extensive lesions left hemiplegia, mental dysfunction and retrobulbar neuritis. ( 10498230 )
1999
9
Bilateral retrobulbar neuritis following measles in an adult. ( 10624445 )
1999
10
Retrobulbar neuritis in a patient with acquired immune deficiency syndrome. ( 8739690 )
1996
11
Acute unilateral papillitis versus retrobulbar neuritis: relation to multiple sclerosis. ( 9345439 )
1996
12
Anterior clinoid mucocele masquerading as retrobulbar neuritis. ( 8869971 )
1996
13
Retrobulbar neuritis complicating acute Epstein-Barr virus infection. ( 8075274 )
1994
14
Giant aneurysm of internal carotid artery presenting features of retrobulbar neuritis. ( 1894342 )
1991
15
Retrobulbar neuritis in two patients with falciparum malaria. ( 2084090 )
1990
16
Electrophysiology and perimetry in acute retrobulbar neuritis. ( 2776632 )
1989
17
Surface-coil heat concentration in MR as a possible exacerbating factor in retrobulbar neuritis: is this a local "hot bath test"? ( 2492731 )
1989
18
Uncomplicated retrobulbar neuritis and the development of multiple sclerosis. ( 2763820 )
1989
19
A case of angioimmunoblastic lymphadenopathy associated with a long spontaneous remission, retrobulbar neuritis, a clonal rearrangement of the T-cell receptor gamma chain gene and an unusual marrow infiltration. ( 2846343 )
1988
20
Retrobulbar neuritis in a patient treated with intraarterial cisplatin for head and neck cancer. ( 3179921 )
1988
21
Reflections on the pathogenesis of optic (retrobulbar) neuritis in multiple sclerosis. ( 3211013 )
1988
22
Cluster headache-like headache, Hageman trait deficiency, retrobulbar neuritis, and giant aneurysm. Autonomic function studies. ( 3401913 )
1988
23
Acute retrobulbar neuritis complicating herpes zoster ophthalmicus. ( 3322138 )
1987
24
Sphenoid sinus mucocele (anterior clinoid variant) mimicking diabetic ophthalmoplegia and retrobulbar neuritis. ( 3728609 )
1986
25
The pattern-elicited electroretinogram. II. Retinal responses in retrobulbar neuritis. ( 3748554 )
1986
26
Visual changes mediated by beer in retrobulbar neuritis--an investigative case report. ( 3947612 )
1986
27
Pattern visual evoked potentials and spatial vision in retrobulbar neuritis and multiple sclerosis. ( 6691824 )
1984
28
The 'flight of colours' test in multiple sclerosis, retrobulbar neuritis and healthy controls. ( 6329581 )
1984
29
Dichotomy of psychophysical responses in retrobulbar neuritis. ( 6709363 )
1984
30
A case report of retrobulbar neuritis due to multiple sclerosis. ( 6807631 )
1982
31
Meningioma presenting with recurrent retrobulbar neuritis. ( 7079911 )
1982
32
Diagnosing acute retrobulbar neuritis by vitreous fluorophotometry. ( 7246699 )
1981
33
Hemiplegia and retrobulbar neuritis after subarachnoid block. ( 7237225 )
1981
34
Retrobulbar neuritis with neuroretinal edema as a delayed manifestation of carbon monoxide poisoning: case report. ( 116153 )
1979
35
Somatosensory evoked potentials in retrobulbar neuritis. ( 75468 )
1978
36
Acquired color vision defects in retrobulbar neuritis. ( 686121 )
1978
37
Grating test of contrast sensitivity in patients with retrobulbar neuritis. ( 687205 )
1978
38
Retrobulbar neuritis. In vitro evidence of sensitization to myelin basic protein in patients without multiple sclerosis. ( 559264 )
1977
39
Retrobulbar neuritis and central serous chorioretinopathy. ( 925845 )
1977
40
Impaired temporal resolution of vision after acute retrobulbar neuritis. ( 990898 )
1976
41
Delayed visual perception and delayed visual evoked potentials in the spinal form of multiple sclerosis and in retrobulbar neuritis. ( 963530 )
1976
42
Retrobulbar neuritis and infectious mononucleosis. ( 174775 )
1975
43
Editorial: Retrobulbar neuritis revisited. ( 1078940 )
1975
44
Delay in visual perception in unilateral optic atrophy after retrobulbar neuritis. ( 4434172 )
1974
45
Clinical studies of multiple sclerosis in Japan. Multiple sclerosis starting with retrobulbar neuritis. ( 4140896 )
1974
46
Bilateral retrobulbar neuritis secondary to mumps. ( 4847472 )
1974
47
Acute retrobulbar neuritis--a retrospective study. ( 5067784 )
1972
48
Retrobulbar neuritis as an early symptom of Guillain-Barre syndrome. Report of a case. ( 4338297 )
1972
49
The visibility of the Goldmann's perimeter coloured targets in the ageing and in retrobulbar neuritis. ( 4544969 )
1972
50
Solitary intracranial plasmacytoma mistaken for retrobulbar neuritis. ( 5020174 )
1972

Variations for Acute Retrobulbar Neuritis

Expression for Acute Retrobulbar Neuritis

Search GEO for disease gene expression data for Acute Retrobulbar Neuritis.

Pathways for Acute Retrobulbar Neuritis

GO Terms for Acute Retrobulbar Neuritis

Cellular components related to Acute Retrobulbar Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.35 CDC42 DNAI1 DNAI2 MBP RHO
2 outer dynein arm GO:0036157 8.62 DNAI1 DNAI2

Biological processes related to Acute Retrobulbar Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.54 EDN1 MT-ND4 MYH9
2 response to hypoxia GO:0001666 9.43 EDN1 MT-CYB MT-ND4
3 cilium movement GO:0003341 9.32 DNAI1 DNAI2
4 response to cadmium ion GO:0046686 9.16 B2M MT-CYB
5 outer dynein arm assembly GO:0036158 8.96 DNAI1 DNAI2
6 electron transport coupled proton transport GO:0015990 8.62 MT-CYB MT-ND4

Molecular functions related to Acute Retrobulbar Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 9.26 DNAI1 DNAI2
2 dynein light chain binding GO:0045503 9.16 DNAI1 DNAI2
3 motor activity GO:0003774 9.13 DNAI1 DNAI2 MYH9
4 dynein heavy chain binding GO:0045504 8.62 DNAI1 DNAI2
5 protein binding GO:0005515 10.13 B2M CDC42 DNAI1 DNAI2 DNAJB6 EDN1

Sources for Acute Retrobulbar Neuritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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