MCID: ACT038
MIFTS: 31

Acute Retrobulbar Neuritis

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Acute Retrobulbar Neuritis

MalaCards integrated aliases for Acute Retrobulbar Neuritis:

Name: Acute Retrobulbar Neuritis 12 15 74
Retrobulbar Neuritis 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:14155
ICD9CM 36 377.32
SNOMED-CT 69 51604006
ICD10 34 H48.1

Summaries for Acute Retrobulbar Neuritis

MalaCards based summary : Acute Retrobulbar Neuritis, also known as retrobulbar neuritis, is related to optic nerve disease and optic neuritis. An important gene associated with Acute Retrobulbar Neuritis is DNAI2 (Dynein Axonemal Intermediate Chain 2). Affiliated tissues include eye, testes and brain, and related phenotype is growth/size/body region.

Related Diseases for Acute Retrobulbar Neuritis

Diseases related to Acute Retrobulbar Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 29.1 EDN1 MBP MT-ND4 UBL4A
2 optic neuritis 11.4
3 neuritis 10.6
4 sparganosis 10.3 MT-CYB MT-ND4
5 leber optic atrophy 10.2 MT-CYB MT-ND4
6 3-methylglutaconic aciduria, type iii 10.2
7 carrion's disease 10.2 MT-CYB MT-ND4
8 scotoma 10.2
9 herpes zoster 10.1
10 herpes zoster ophthalmicus 10.1
11 tritanopia 10.1 MT-ND4 RHO
12 xerophthalmia 10.1 RHO TRIM21
13 pfeiffer syndrome 10.1
14 pernicious anemia 10.1
15 malaria 10.1
16 optic papillitis 10.1
17 mumps 10.1
18 hemiplegia 10.1
19 uveitis 10.1
20 cluster headache 10.1
21 headache 10.1
22 optic disk drusen 10.1 RHO UBL4A
23 tertiary neurosyphilis 10.0 MBP MYH9
24 multiple sclerosis 10.0
25 sinusitis 10.0
26 cranial nerve disease 10.0 MBP MT-ND4 UBL4A
27 retinitis pigmentosa 7 10.0 B2M RHO
28 atrial standstill 1 9.9
29 retinal detachment 9.9
30 factor xii deficiency 9.9
31 myeloma, multiple 9.9
32 cataract 9.9
33 hereditary ataxia 9.9
34 lymphoma 9.9
35 asymptomatic neurosyphilis 9.9
36 osteomyelitis 9.9
37 meningoencephalitis 9.9
38 rabies 9.9
39 choroiditis 9.9
40 nutritional optic neuropathy 9.9
41 arachnoiditis 9.9
42 guillain-barre syndrome 9.9
43 neurilemmoma 9.9
44 syringomyelia 9.9
45 plasmacytoma 9.9
46 chiasmal syndrome 9.9
47 acquired immunodeficiency syndrome 9.9
48 hyperthyroidism 9.9
49 measles 9.9
50 neuropathy 9.9

Graphical network of the top 20 diseases related to Acute Retrobulbar Neuritis:



Diseases related to Acute Retrobulbar Neuritis

Symptoms & Phenotypes for Acute Retrobulbar Neuritis

MGI Mouse Phenotypes related to Acute Retrobulbar Neuritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.28 B2M DNAI1 DNAI2 DNAJB6 EDN1 FANCB

Drugs & Therapeutics for Acute Retrobulbar Neuritis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pupillometry Dynamic Measures in Patients Without Ocular or Neurological Disease Completed NCT02894281

Search NIH Clinical Center for Acute Retrobulbar Neuritis

Genetic Tests for Acute Retrobulbar Neuritis

Anatomical Context for Acute Retrobulbar Neuritis

MalaCards organs/tissues related to Acute Retrobulbar Neuritis:

42
Eye, Testes, Brain, Heart, T Cells, Kidney

Publications for Acute Retrobulbar Neuritis

Articles related to Acute Retrobulbar Neuritis:

(show top 50) (show all 155)
# Title Authors Year
1
Strain and Shear Wave Elastography in Diagnosis of Retrobulbar Neuritis. ( 31022061 )
2019
2
Herpes zoster ophthalmicus with retrobulbar neuritis. ( 28242890 )
2016
3
Bilateral retrobulbar neuritis in an adolescent boy with lymphoma. ( 21397810 )
2011
4
Influence of retrobulbar neuritis and papillitis on echographically measured optic nerve diameter. ( 20225632 )
2010
5
Extensive meningoencephalitis, retrobulbar neuritis and pulmonary involvement in a patient of neurobrucellosis. ( 17558123 )
2007
6
The correlation of changes of the optic nerve diameter in the acute retrobulbar neuritis with the brain changes in multiple sclerosis. ( 16417174 )
2005
7
Bilateral retrobulbar neuritis associated with mumps. ( 15814053 )
2005
8
Diagnostic and therapeutic doubts in retrobulbar neuritis in children. ( 16193696 )
2005
9
Falciparum malaria induced retrobulbar neuritis. ( 15235217 )
2004
10
Retrobulbar neuritis following rabies vaccination. ( 15267054 )
2004
11
Retrobulbar neuritis associated with Borrelia afzelii infection. ( 12061028 )
2002
12
Acute asymmetric upper nasal quandrantanopsia caused by a chiasmal colloid cyst in a patient with multiple sclerosis and bilateral retrobulbar neuritis. ( 11476707 )
2001
13
Multiple sclerosis with extensive lesions left hemiplegia, mental dysfunction and retrobulbar neuritis. ( 10498230 )
1999
14
Bilateral retrobulbar neuritis following measles in an adult. ( 10624445 )
1999
15
Retrobulbar neuritis in a patient with acquired immune deficiency syndrome. ( 8739690 )
1996
16
Anterior clinoid mucocele masquerading as retrobulbar neuritis. ( 8869971 )
1996
17
Acute unilateral papillitis versus retrobulbar neuritis: relation to multiple sclerosis. ( 9345439 )
1996
18
Bilateral retrobulbar neuritis following unilateral herpes zoster ophthalmicus. ( 8183526 )
1994
19
Retrobulbar neuritis complicating acute Epstein-Barr virus infection. ( 8075274 )
1994
20
Giant aneurysm of internal carotid artery presenting features of retrobulbar neuritis. ( 1894342 )
1991
21
Retrobulbar neuritis in two patients with falciparum malaria. ( 2084090 )
1990
22
Electrophysiology and perimetry in acute retrobulbar neuritis. ( 2776632 )
1989
23
Surface-coil heat concentration in MR as a possible exacerbating factor in retrobulbar neuritis: is this a local "hot bath test"? ( 2492731 )
1989
24
Uncomplicated retrobulbar neuritis and the development of multiple sclerosis. ( 2763820 )
1989
25
Cluster headache-like headache, Hageman trait deficiency, retrobulbar neuritis, and giant aneurysm. Autonomic function studies. ( 3401913 )
1988
26
A case of angioimmunoblastic lymphadenopathy associated with a long spontaneous remission, retrobulbar neuritis, a clonal rearrangement of the T-cell receptor gamma chain gene and an unusual marrow infiltration. ( 2846343 )
1988
27
Retrobulbar neuritis in a patient treated with intraarterial cisplatin for head and neck cancer. ( 3179921 )
1988
28
Reflections on the pathogenesis of optic (retrobulbar) neuritis in multiple sclerosis. ( 3211013 )
1988
29
Acute retrobulbar neuritis complicating herpes zoster ophthalmicus. ( 3322138 )
1987
30
Retrobulbar neuritis as the first sign of the glucagonoma syndrome. ( 2826358 )
1987
31
Sphenoid sinus mucocele (anterior clinoid variant) mimicking diabetic ophthalmoplegia and retrobulbar neuritis. ( 3728609 )
1986
32
The pattern-elicited electroretinogram. II. Retinal responses in retrobulbar neuritis. ( 3748554 )
1986
33
Neurosyphilis and retrobulbar neuritis in a patient with AIDS. ( 3767211 )
1986
34
Visual changes mediated by beer in retrobulbar neuritis--an investigative case report. ( 3947612 )
1986
35
The 'flight of colours' test in multiple sclerosis, retrobulbar neuritis and healthy controls. ( 6329581 )
1984
36
Pattern visual evoked potentials and spatial vision in retrobulbar neuritis and multiple sclerosis. ( 6691824 )
1984
37
Dichotomy of psychophysical responses in retrobulbar neuritis. ( 6709363 )
1984
38
Herpes zoster ophthalmicus with retrobulbar neuritis. A case report. ( 6605018 )
1983
39
A case report of retrobulbar neuritis due to multiple sclerosis. ( 6807631 )
1982
40
Meningioma presenting with recurrent retrobulbar neuritis. ( 7079911 )
1982
41
Diagnosing acute retrobulbar neuritis by vitreous fluorophotometry. ( 7246699 )
1981
42
Hemiplegia and retrobulbar neuritis after subarachnoid block. ( 7237225 )
1981
43
Retrobulbar neuritis with neuroretinal edema as a delayed manifestation of carbon monoxide poisoning: case report. ( 116153 )
1979
44
Somatosensory evoked potentials in retrobulbar neuritis. ( 75468 )
1978
45
Acquired color vision defects in retrobulbar neuritis. ( 686121 )
1978
46
Grating test of contrast sensitivity in patients with retrobulbar neuritis. ( 687205 )
1978
47
Retrobulbar neuritis and central serous chorioretinopathy. ( 925845 )
1977
48
Retrobulbar neuritis. In vitro evidence of sensitization to myelin basic protein in patients without multiple sclerosis. ( 559264 )
1977
49
Impaired temporal resolution of vision after acute retrobulbar neuritis. ( 990898 )
1976
50
A new headache syndrome? Headache resembling cluster headache (Horton's headache), with recurring bouts of homolateral retrobulbar neuritis, partial factor XII deficiency, bleeding tendency and a heterolateral convulsive episode. ( 1254470 )
1976

Variations for Acute Retrobulbar Neuritis

Expression for Acute Retrobulbar Neuritis

Search GEO for disease gene expression data for Acute Retrobulbar Neuritis.

Pathways for Acute Retrobulbar Neuritis

GO Terms for Acute Retrobulbar Neuritis

Cellular components related to Acute Retrobulbar Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.35 CDC42 DNAI1 DNAI2 MBP RHO
2 dynein complex GO:0030286 9.16 DNAI1 DNAI2
3 outer dynein arm GO:0036157 8.62 DNAI1 DNAI2

Biological processes related to Acute Retrobulbar Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.54 EDN1 MT-ND4 MYH9
2 response to hypoxia GO:0001666 9.43 EDN1 MT-CYB MT-ND4
3 response to nicotine GO:0035094 9.4 EDN1 MT-ND4
4 cilium movement GO:0003341 9.32 DNAI1 DNAI2
5 response to cadmium ion GO:0046686 9.16 B2M MT-CYB
6 outer dynein arm assembly GO:0036158 8.96 DNAI1 DNAI2
7 electron transport coupled proton transport GO:0015990 8.62 MT-CYB MT-ND4

Molecular functions related to Acute Retrobulbar Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 9.26 DNAI1 DNAI2
2 dynein light chain binding GO:0045503 9.16 DNAI1 DNAI2
3 dynein heavy chain binding GO:0045504 8.96 DNAI1 DNAI2
4 motor activity GO:0003774 8.8 DNAI1 DNAI2 MYH9

Sources for Acute Retrobulbar Neuritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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