MCID: ACT038
MIFTS: 31

Acute Retrobulbar Neuritis

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Acute Retrobulbar Neuritis

MalaCards integrated aliases for Acute Retrobulbar Neuritis:

Name: Acute Retrobulbar Neuritis 12 15 74
Retrobulbar Neuritis 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:14155
ICD9CM 36 377.32
SNOMED-CT 69 51604006
ICD10 34 H48.1

Summaries for Acute Retrobulbar Neuritis

MalaCards based summary : Acute Retrobulbar Neuritis, also known as retrobulbar neuritis, is related to optic nerve disease and optic neuritis. An important gene associated with Acute Retrobulbar Neuritis is DNAI2 (Dynein Axonemal Intermediate Chain 2). Affiliated tissues include eye, testes and brain, and related phenotype is growth/size/body region.

Related Diseases for Acute Retrobulbar Neuritis

Diseases related to Acute Retrobulbar Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 29.1 EDN1 MBP MT-ND4 UBL4A
2 optic neuritis 11.4
3 neuritis 10.5
4 sparganosis 10.3 MT-CYB MT-ND4
5 leber optic atrophy 10.2 MT-CYB MT-ND4
6 3-methylglutaconic aciduria, type iii 10.2
7 carrion's disease 10.2 MT-CYB MT-ND4
8 scotoma 10.1
9 herpes zoster 10.1
10 herpes zoster ophthalmicus 10.1
11 tritanopia 10.1 MT-ND4 RHO
12 xerophthalmia 10.1 RHO TRIM21
13 pfeiffer syndrome 10.1
14 pernicious anemia 10.1
15 malaria 10.1
16 mumps 10.1
17 hemiplegia 10.1
18 uveitis 10.1
19 cluster headache 10.1
20 headache 10.1
21 optic disk drusen 10.1 RHO UBL4A
22 tertiary neurosyphilis 10.0 MBP MYH9
23 multiple sclerosis 10.0
24 sinusitis 10.0
25 cranial nerve disease 10.0 MBP MT-ND4 UBL4A
26 retinitis pigmentosa 7 10.0 B2M RHO
27 atrial standstill 1 9.9
28 retinal detachment 9.9
29 factor xii deficiency 9.9
30 myeloma, multiple 9.9
31 cataract 9.9
32 hereditary ataxia 9.9
33 lymphoma 9.9
34 optic papillitis 9.9
35 osteomyelitis 9.9
36 meningoencephalitis 9.9
37 rabies 9.9
38 choroiditis 9.9
39 nutritional optic neuropathy 9.9
40 arachnoiditis 9.9
41 guillain-barre syndrome 9.9
42 neurilemmoma 9.9
43 syringomyelia 9.9
44 plasmacytoma 9.9
45 chiasmal syndrome 9.9
46 acquired immunodeficiency syndrome 9.9
47 hyperthyroidism 9.9
48 measles 9.9
49 neuropathy 9.9
50 meningitis 9.9

Graphical network of the top 20 diseases related to Acute Retrobulbar Neuritis:



Diseases related to Acute Retrobulbar Neuritis

Symptoms & Phenotypes for Acute Retrobulbar Neuritis

MGI Mouse Phenotypes related to Acute Retrobulbar Neuritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.28 B2M DNAI1 DNAI2 DNAJB6 EDN1 FANCB

Drugs & Therapeutics for Acute Retrobulbar Neuritis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pupillometry Dynamic Measures in Patients Without Ocular or Neurological Disease Completed NCT02894281

Search NIH Clinical Center for Acute Retrobulbar Neuritis

Genetic Tests for Acute Retrobulbar Neuritis

Anatomical Context for Acute Retrobulbar Neuritis

MalaCards organs/tissues related to Acute Retrobulbar Neuritis:

42
Eye, Testes, Brain, T Cells

Publications for Acute Retrobulbar Neuritis

Articles related to Acute Retrobulbar Neuritis:

(show top 50) (show all 136)
# Title Authors Year
1
The correlation of changes of the optic nerve diameter in the acute retrobulbar neuritis with the brain changes in multiple sclerosis. ( 16417174 )
2005
2
Bilateral retrobulbar neuritis associated with mumps. ( 15814053 )
2005
3
Diagnostic and therapeutic doubts in retrobulbar neuritis in children. ( 16193696 )
2005
4
Falciparum malaria induced retrobulbar neuritis. ( 15235217 )
2004
5
Retrobulbar neuritis following rabies vaccination. ( 15267054 )
2004
6
Retrobulbar neuritis associated with Borrelia afzelii infection. ( 12061028 )
2002
7
Acute asymmetric upper nasal quandrantanopsia caused by a chiasmal colloid cyst in a patient with multiple sclerosis and bilateral retrobulbar neuritis. ( 11476707 )
2001
8
Multiple sclerosis with extensive lesions left hemiplegia, mental dysfunction and retrobulbar neuritis. ( 10498230 )
1999
9
Bilateral retrobulbar neuritis following measles in an adult. ( 10624445 )
1999
10
Retrobulbar neuritis in a patient with acquired immune deficiency syndrome. ( 8739690 )
1996
11
Anterior clinoid mucocele masquerading as retrobulbar neuritis. ( 8869971 )
1996
12
Acute unilateral papillitis versus retrobulbar neuritis: relation to multiple sclerosis. ( 9345439 )
1996
13
Retrobulbar neuritis complicating acute Epstein-Barr virus infection. ( 8075274 )
1994
14
Giant aneurysm of internal carotid artery presenting features of retrobulbar neuritis. ( 1894342 )
1991
15
Retrobulbar neuritis in two patients with falciparum malaria. ( 2084090 )
1990
16
Electrophysiology and perimetry in acute retrobulbar neuritis. ( 2776632 )
1989
17
Surface-coil heat concentration in MR as a possible exacerbating factor in retrobulbar neuritis: is this a local "hot bath test"? ( 2492731 )
1989
18
Uncomplicated retrobulbar neuritis and the development of multiple sclerosis. ( 2763820 )
1989
19
Cluster headache-like headache, Hageman trait deficiency, retrobulbar neuritis, and giant aneurysm. Autonomic function studies. ( 3401913 )
1988
20
Retrobulbar neuritis in a patient treated with intraarterial cisplatin for head and neck cancer. ( 3179921 )
1988
21
A case of angioimmunoblastic lymphadenopathy associated with a long spontaneous remission, retrobulbar neuritis, a clonal rearrangement of the T-cell receptor gamma chain gene and an unusual marrow infiltration. ( 2846343 )
1988
22
Reflections on the pathogenesis of optic (retrobulbar) neuritis in multiple sclerosis. ( 3211013 )
1988
23
Acute retrobulbar neuritis complicating herpes zoster ophthalmicus. ( 3322138 )
1987
24
Sphenoid sinus mucocele (anterior clinoid variant) mimicking diabetic ophthalmoplegia and retrobulbar neuritis. ( 3728609 )
1986
25
The pattern-elicited electroretinogram. II. Retinal responses in retrobulbar neuritis. ( 3748554 )
1986
26
Visual changes mediated by beer in retrobulbar neuritis--an investigative case report. ( 3947612 )
1986
27
The 'flight of colours' test in multiple sclerosis, retrobulbar neuritis and healthy controls. ( 6329581 )
1984
28
Pattern visual evoked potentials and spatial vision in retrobulbar neuritis and multiple sclerosis. ( 6691824 )
1984
29
Dichotomy of psychophysical responses in retrobulbar neuritis. ( 6709363 )
1984
30
A case report of retrobulbar neuritis due to multiple sclerosis. ( 6807631 )
1982
31
Meningioma presenting with recurrent retrobulbar neuritis. ( 7079911 )
1982
32
Diagnosing acute retrobulbar neuritis by vitreous fluorophotometry. ( 7246699 )
1981
33
Hemiplegia and retrobulbar neuritis after subarachnoid block. ( 7237225 )
1981
34
Retrobulbar neuritis with neuroretinal edema as a delayed manifestation of carbon monoxide poisoning: case report. ( 116153 )
1979
35
Acquired color vision defects in retrobulbar neuritis. ( 686121 )
1978
36
Grating test of contrast sensitivity in patients with retrobulbar neuritis. ( 687205 )
1978
37
Somatosensory evoked potentials in retrobulbar neuritis. ( 75468 )
1978
38
Retrobulbar neuritis and central serous chorioretinopathy. ( 925845 )
1977
39
Retrobulbar neuritis. In vitro evidence of sensitization to myelin basic protein in patients without multiple sclerosis. ( 559264 )
1977
40
Impaired temporal resolution of vision after acute retrobulbar neuritis. ( 990898 )
1976
41
Delayed visual perception and delayed visual evoked potentials in the spinal form of multiple sclerosis and in retrobulbar neuritis. ( 963530 )
1976
42
Retrobulbar neuritis and infectious mononucleosis. ( 174775 )
1975
43
Editorial: Retrobulbar neuritis revisited. ( 1078940 )
1975
44
Bilateral retrobulbar neuritis secondary to mumps. ( 4847472 )
1974
45
Delay in visual perception in unilateral optic atrophy after retrobulbar neuritis. ( 4434172 )
1974
46
Clinical studies of multiple sclerosis in Japan. Multiple sclerosis starting with retrobulbar neuritis. ( 4140896 )
1974
47
Acute retrobulbar neuritis--a retrospective study. ( 5067784 )
1972
48
Solitary intracranial plasmacytoma mistaken for retrobulbar neuritis. ( 5020174 )
1972
49
Retrobulbar neuritis as an early symptom of Guillain-Barre syndrome. Report of a case. ( 4338297 )
1972
50
The visibility of the Goldmann's perimeter coloured targets in the ageing and in retrobulbar neuritis. ( 4544969 )
1972

Variations for Acute Retrobulbar Neuritis

Expression for Acute Retrobulbar Neuritis

Search GEO for disease gene expression data for Acute Retrobulbar Neuritis.

Pathways for Acute Retrobulbar Neuritis

GO Terms for Acute Retrobulbar Neuritis

Cellular components related to Acute Retrobulbar Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.35 CDC42 DNAI1 DNAI2 MBP RHO
2 dynein complex GO:0030286 9.16 DNAI1 DNAI2
3 outer dynein arm GO:0036157 8.62 DNAI1 DNAI2

Biological processes related to Acute Retrobulbar Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.54 EDN1 MT-ND4 MYH9
2 response to hypoxia GO:0001666 9.43 EDN1 MT-CYB MT-ND4
3 response to nicotine GO:0035094 9.4 EDN1 MT-ND4
4 cilium movement GO:0003341 9.32 DNAI1 DNAI2
5 response to cadmium ion GO:0046686 9.16 B2M MT-CYB
6 outer dynein arm assembly GO:0036158 8.96 DNAI1 DNAI2
7 electron transport coupled proton transport GO:0015990 8.62 MT-CYB MT-ND4

Molecular functions related to Acute Retrobulbar Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 9.26 DNAI1 DNAI2
2 dynein light chain binding GO:0045503 9.16 DNAI1 DNAI2
3 dynein heavy chain binding GO:0045504 8.96 DNAI1 DNAI2
4 motor activity GO:0003774 8.8 DNAI1 DNAI2 MYH9

Sources for Acute Retrobulbar Neuritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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