MCID: ACT084
MIFTS: 42

Acute Stress Disorder

Categories: Mental diseases

Aliases & Classifications for Acute Stress Disorder

MalaCards integrated aliases for Acute Stress Disorder:

Name: Acute Stress Disorder 12 15
Stress Disorders, Traumatic, Acute 72
Stress Disorders, Traumatic 72
Traumatic Stress Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6088
ICD9CM 35 308.3
UMLS 72 C0029488 C0038441 C0236816

Summaries for Acute Stress Disorder

Disease Ontology : 12 An anxiety disorder that has symptom flashbacks, has symptom bad dreams, has symptom frightening thoughts, has symptom avoidance or has symptom hyperarousal of PTSD occurring within one month of a traumatic experience as Acute Stress Disorder or ASD.

MalaCards based summary : Acute Stress Disorder, also known as stress disorders, traumatic, acute, is related to combat disorder and alcohol use disorder, and has symptoms including flashbacks, bad dreams and frightening thoughts. An important gene associated with Acute Stress Disorder is CRP (C-Reactive Protein). The drugs Tramadol and Diazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes.

Related Diseases for Acute Stress Disorder

Diseases related to Acute Stress Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 combat disorder 31.3 DIS3 ACKR1
2 alcohol use disorder 10.6
3 substance abuse 10.5
4 chronic pain 10.5
5 personality disorder 10.5
6 major affective disorder 8 10.4
7 major affective disorder 9 10.4
8 bipolar disorder 10.4
9 post-traumatic stress disorder 10.4
10 borderline personality disorder 10.4
11 psychotic disorder 10.4
12 sleep disorder 10.4
13 neurotic disorder 10.4
14 sleep apnea 10.3
15 alexithymia 10.3
16 fibromyalgia 10.3
17 subacute delirium 10.3
18 migraine with or without aura 1 10.3
19 attention deficit-hyperactivity disorder 10.2
20 dementia 10.2
21 substance dependence 10.2
22 headache 10.2
23 schizophrenia 10.2
24 sexual disorder 10.2
25 disease of mental health 10.2
26 head injury 10.2
27 somatization disorder 10.2
28 coronary heart disease 1 10.2
29 multiple personality disorder 10.2
30 avoidant personality disorder 10.2
31 eating disorder 10.2
32 parastremmatic dwarfism 10.1
33 ocular motor apraxia 10.1
34 heart disease 10.1
35 back pain 10.1
36 dysthymic disorder 10.1
37 chronic fatigue syndrome 10.1
38 irritable bowel syndrome 10.1
39 cocaine dependence 10.1
40 acute respiratory distress syndrome 10.1
41 spinal cord injury 10.1
42 brain injury 10.1
43 traumatic brain injury 10.1
44 tobacco addiction 10.0
45 autism 10.0
46 bulimia nervosa 10.0
47 smoking as a quantitative trait locus 3 10.0
48 alacrima, achalasia, and mental retardation syndrome 10.0
49 antisocial personality disorder 10.0
50 impotence 10.0

Comorbidity relations with Acute Stress Disorder via Phenotypic Disease Network (PDN):


Anxiety Hypertension, Essential
Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Acute Stress Disorder:



Diseases related to Acute Stress Disorder

Symptoms & Phenotypes for Acute Stress Disorder

Symptoms:

12
  • flashbacks
  • bad dreams
  • frightening thoughts
  • avoidance
  • hyperarousal of ptsd occurring

UMLS symptoms related to Acute Stress Disorder:


agitation, motor restlessness, acute stress/transient/situational disturbance

Drugs & Therapeutics for Acute Stress Disorder

Drugs for Acute Stress Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 336)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
2
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
3
Ziprasidone Approved Phase 4 146939-27-7 60854
4
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
5
Mifepristone Approved, Investigational Phase 4 84371-65-3 55245
6
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
7
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
8
Mianserin Approved, Investigational Phase 4 24219-97-4 4184
9
Histamine Approved, Investigational Phase 4 51-45-6 774
10
Haloperidol Approved Phase 4 52-86-8 3559
11
Memantine Approved, Investigational Phase 4 19982-08-2 4054
12
Mirtazapine Approved Phase 4 61337-67-5, 85650-52-8 4205
13
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
14
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
15
Asenapine Approved Phase 4 65576-45-6, 85650-56-2 3001386
16
Levodopa Approved Phase 4 59-92-7 6047
17
Citalopram Approved Phase 4 59729-33-8 2771
18
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
19
Vortioxetine Approved, Investigational Phase 4 508233-74-7 9966051
20
Ondansetron Approved Phase 4 99614-02-5 4595
21
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
22
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078
23
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
24
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
25
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
26
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
27
Promethazine Approved, Investigational Phase 4 60-87-7 4927
28
Suvorexant Approved, Investigational Phase 4 1030377-33-3
29
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
30
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
31
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
32
Sodium citrate Approved, Investigational Phase 4 68-04-2
33
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
34
Carbon monoxide Approved, Investigational Phase 4 630-08-0 281
35
Sertraline Approved Phase 4 79617-96-2 68617
36
Propranolol Approved, Investigational Phase 4 525-66-6 4946
37
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
38
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
39
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
40 Olive Phase 4
41 Adrenergic Agents Phase 4
42 Adrenergic Antagonists Phase 4
43 Antihypertensive Agents Phase 4
44 Antiparkinson Agents Phase 4
45 Autonomic Agents Phase 4
46 Dopamine agonists Phase 4
47 Quetiapine Fumarate Phase 4 111974-72-2
48 Protective Agents Phase 4
49 Contraceptives, Oral Phase 4
50 Contraceptive Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 1193)
# Name Status NCT ID Phase Drugs
1 A Prospective Double Blind Randomized Placebo Controlled Trial of Repetitive Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder Unknown status NCT00134446 Phase 4
2 The Effect of 21-Days Intranasal Oxytocin on Clinical Symptoms and Social Function in Patients With Post Traumatic Stress Disorder (PTSD), a Randomized Controled Trail Unknown status NCT02336568 Phase 4 Oxytoine;PLACEBO
3 Treatment of Sleep Disturbances in Trauma-affected Refugees: A Randomised Controlled Trial Unknown status NCT02761161 Phase 4 Mianserin
4 A Double-Blind, Placebo-Controlled, Flexible-Dose Pilot Clinical Trial of Once-Daily Extended-Release Tramadol for the Treatment of PTSD Unknown status NCT01517711 Phase 4 Tramadol;Placebo
5 Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure Unknown status NCT00633685 Phase 4 Fluoxetine;Placebo
6 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
7 Early Pharmacological Intervention With Diazepam in the Emergency Room Setting to Prevent Posttraumatic Stress Disorder (PTSD). Unknown status NCT01221883 Phase 4 Diazepam
8 Double Blind, Placebo-Controlled Trial of THC as add-on Therapy for PTSD Unknown status NCT00965809 Phase 4 Tetrahydrocannabinol
9 Posttraumatic Stress Disorder and Affective Functioning: A Test of the Potentially Normalizing Effects of Oxytocin Unknown status NCT02546570 Phase 4 Oxytocin;Placebo
10 Efficacy of an SSRI in Acute Stress Disorder and PTSD Completed NCT00050804 Phase 4 sertraline
11 Neurofunctional Markers of SSRI Treatment Response in PTSD Completed NCT00700999 Phase 4 Paroxetine
12 Reducing Suicidal Ideation Through Treatment of Nightmares-PTSD Completed NCT02199652 Phase 4 Prazosin;Placebo
13 Naltrexone and Cognitive-Behavioral Therapy for Patients With Alcoholism and Post-Traumatic Stress Disorder Completed NCT00006489 Phase 4 Naltrexone;Placebo
14 Effects of Escitalopram on Autonomic Reactivity in Post Traumatic Stress Disorder Among Veterans of Operation Enduring Freedom and Iraqi Freedom (OEF/OIF) Completed NCT01271244 Phase 4 Escitalopram
15 Coordinated Anxiety Learning and Management (CALM): Improving Primary Care Anxiety Outcomes Completed NCT00347269 Phase 4 Psychotropic medication optimization
16 Eszopiclone for the Treatment of PTSD Completed NCT01605253 Phase 4 Eszopiclone;Placebo
17 The Outcome of Treatment of Traumatised Refugees With Trauma-Focused Cognitive Behavioural Therapy and / or Antidepressants - a Randomised Controlled Trial Completed NCT00917397 Phase 4 Sertraline
18 Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder Completed NCT00120250 Phase 4 Eszopiclone
19 Cognitive Behavioral Therapy vs. Sertraline in the Treatment of Post Traumatic Stress Disorder Completed NCT00391430 Phase 4 Sertraline
20 Randomized Trial of Sertraline, Prolonged Exposure, and Their Combination for Post-traumatic Stress Disorder (PTSD) in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF). Completed NCT01524133 Phase 4 Sertraline
21 Risperidone Monotherapy in the Treatment of PTSD in Women Survivors of Domestic Abuse and Rape Trauma: a Double-Blind, Placebo Controlled, Randomized Clinical Trial Completed NCT00208182 Phase 4 Risperidone
22 Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD) Completed NCT00203463 Phase 4 topiramate
23 The Effect of Intranasal Oxytocin on Emphatic Abilities in Patients With PTSD Completed NCT01325168 Phase 4 syntocinon nasal spray;placebo nasal spray
24 The Effect of Different Dose of Dexmedetomidine Combined With Hydromorphone in Children With Tonsillectomy and Adenoidectomy Completed NCT03760809 Phase 4 Dexmedetomidine 0.5μg/kg;Dexmedetomidine 1μg/kg
25 The Treatment of Traumatised Refugees With Sertraline Versus Venlafaxine in Combination With Psychotherapy - a Randomised Clinical Study Completed NCT01569685 Phase 4 Venlafaxine;Sertraline
26 A Pilot Study to Assess the Effects of Doxazosin on Polysomnography in PTSD Completed NCT01959022 Phase 4 Doxazosin XL
27 Geodon (Ziprasidone) for Posttraumatic Stress Disorder Completed NCT00208208 Phase 4 Ziprasidone
28 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Posttraumatic Stress Disorder in Civilians Completed NCT00208130 Phase 4 Topiramate
29 Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy Completed NCT01087736 Phase 4 Topiramate
30 Developing Memory Reconsolidation Blockers as Novel PTSD Treatments Completed NCT01490697 Phase 4 Mifepristone;d-Cycloserine;Placebo-matching Mifepristone;Placebo-matching d-Cycloserine (DCS)
31 Preventing Post-Operative Delirium in Pneumonectomy, Esophagectomy and Thoracotomy Patients Completed NCT02213900 Phase 4 Haloperidol;Placebo
32 An Open-Label Trial of Memantine for Cognitive Impairment in Patients With Post-Traumatic Stress Disorder Completed NCT02258828 Phase 4 Memantine
33 Atomoxetine in Comorbid ADHD/PTSD: A Pilot, Placebo-Controlled Feasibility Study Completed NCT02287038 Phase 4 Atomoxetine 80 MG
34 Combined Mirtazapine and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment of Post-traumatic Stress Disorder (PTSD) Completed NCT01178671 Phase 4 Mirtazapine;Sertraline
35 A Double-blind, Placebo-controlled Randomized Trial of Vilazodone in the Treatment of Posttraumatic Stress Disorder Completed NCT01715519 Phase 4 Treatment (Viibryd)
36 Interest for a Relative of Seeing Himself Proposing to Witness Resuscitation of a Family Member Victim of a Cardiac Arrest Completed NCT01009606 Phase 4
37 Minocycline for Treatment of Posttraumatic Stress Disorder in Veterans Completed NCT03340350 Phase 4 Minocycline
38 Combination Treatment for PTSD After the WTC Attack Completed NCT01130103 Phase 4 Paroxetine
39 Effects of Hydrocortisone and D-Cycloserine on Fear Extinction in Veterans With Posttraumatic Stress Disorder Completed NCT00674570 Phase 4 Hydrocortisone;D-Cycloserine;Placebo
40 An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder Completed NCT01587118 Phase 4 Adjunctive asenapine
41 Secondary Prevention With Paroxetine vs. Placebo in Subthreshold Posttraumatic Stress Disorder (PTSD) Completed NCT00560612 Phase 4 Paroxetine;Placebo
42 A Placebo-controlled Trial of Adjunctive Quetiapine for Refractory PTSD Completed NCT00292370 Phase 4 Open Label (OL) Paroxetine;Placebo;Quetiapine
43 Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder Completed NCT01681849 Phase 4 Placebo;Paroxetine
44 Aripiprazole (Abilify) Therapy for Reducing Comorbid Substance Abuse Completed NCT00208169 Phase 4 Aripiprazole
45 Effects of Paxil CR on Neural Circuits in PTSD Completed NCT00672776 Phase 4 paroxetine;placebo
46 Prazosin Treatment for Combat Trauma PTSD Nightmares and Sleep Disturbance Completed NCT00108420 Phase 4 Prazosin
47 A Double-Blind Placebo-Controlled Trial of Prazosin for the Treatment of Alcohol Dependence Completed NCT00167687 Phase 4 prazosin
48 Telemedicine Outreach for Post Traumatic Stress in CBOCs Completed NCT00821678 Phase 4
49 Randomized Clinical Trial to Study the Topiramate Efficacy for Posttraumatic Disorder Treatment Completed NCT00725920 Phase 4 Topiramate;placebo control group
50 12 Week Prospective Double Blind Placebo Controlled Randomized Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety Completed NCT00352469 Phase 4 Seroquel XR

Search NIH Clinical Center for Acute Stress Disorder

Genetic Tests for Acute Stress Disorder

Anatomical Context for Acute Stress Disorder

MalaCards organs/tissues related to Acute Stress Disorder:

41
Brain, Eye, Testes, Amygdala, Cortex, Heart, Prefrontal Cortex

Publications for Acute Stress Disorder

Articles related to Acute Stress Disorder:

(show top 50) (show all 10351)
# Title Authors PMID Year
1
Effects of intranasal oxytocin on distraction as emotion regulation strategy in patients with post-traumatic stress disorder. 38
30554861 2019
2
HPA axis function and diurnal cortisol in post-traumatic stress disorder: A systematic review. 38
31236437 2019
3
Adult hippocampal neurogenesis for systems consolidation of memory. 38
31201874 2019
4
The blockade of the serotoninergic receptors 5-HT5A, 5-HT6 and 5-HT7 in the basolateral amygdala, but not in the hippocampus facilitate the extinction of fear memory. 38
31233821 2019
5
A syndemic of psychosocial and mental health problems in Liberia: Examining the link to transactional sex among young pregnant women. 38
31010396 2019
6
Social rhythm regularity moderates the relationship between sleep disruption and depressive symptoms in veterans with post-traumatic stress disorder and major depressive disorder. 38
31368369 2019
7
Common pathways and communication between the brain and heart: connecting post-traumatic stress disorder and heart failure. 38
31161843 2019
8
Post-traumatic Stress Disorder Symptoms are Associated With Incident Chronic Back Pain: A Longitudinal Twin Study of Older Male Veterans. 38
30985567 2019
9
Molecular targets for the interactive effect of etazolate during post-traumatic stress disorder: Role of oxidative stress, BDNF and histones. 38
31047921 2019
10
Disempowered midwives and traumatised women: Exploring the parallel processes of care provider interaction that contribute to women developing Post Traumatic Stress Disorder (PTSD) post childbirth. 38
31154157 2019
11
Long-term social dysfunction after trauma: What is the prevalence, risk factors, and associated outcomes? 38
31104807 2019
12
How Do Patients with Mental Health Diagnoses Use Online Patient Portals? An Observational Analysis from the Veterans Health Administration. 38
31065908 2019
13
An Examination of the Association Between Post-traumatic Growth and Stress Symptomatology in Cardiac Outpatients. 38
30317415 2019
14
Gender differences in the association of living and working conditions and the mental health of trafficking survivors. 38
31243470 2019
15
Structural, interpersonal, psychosocial, and behavioral risk factors for HIV acquisition among female bar workers in Dar es Salaam, Tanzania. 38
31079476 2019
16
The protective role of mentalizing: Reflective functioning as a mediator between child maltreatment, psychopathology and parental attitude in expecting parents. 38
31255871 2019
17
The Effects of Terrorist Attacks on Symptom Clusters of PTSD: a Comparison with Victims of Other Traumatic Events. 38
31187353 2019
18
Mental health disorder, pain, and pain treatment among long-term care residents: Evidence from the Minimum Data Set 3.0. 38
30404536 2019
19
Unmet Needs of People with Serious Mental Illness: Perspectives from Certified Peer Specialists. 38
31154551 2019
20
Effects of MDMA on attention to positive social cues and pleasantness of affective touch. 38
31042696 2019
21
The effects of trauma on brain and body: A unifying role for the midbrain periaqueductal gray. 38
31254294 2019
22
New neurons restore structural and behavioral abnormalities in a rat model of PTSD. 38
30865372 2019
23
Temporal effect of electroacupuncture on anxiety-like behaviors and c-Fos expression in the anterior cingulate cortex in a rat model of post-traumatic stress disorder. 38
31419458 2019
24
Increased Vascular Pathology in Older Veterans With a Purple Heart Commendation or Chronic Post-Traumatic Stress Disorder. 38
31426715 2019
25
Using patient-reported outcomes to understand the effectiveness of guideline-concordant care for post-traumatic stress disorder in clinical practice. 38
31115137 2019
26
Post-Traumatic Stress Disorder after Civilian Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Prevalence Rates. 38
31238819 2019
27
Psychological characteristics of war veterans after the war in Bosnia and Herzegovina. 38
31127710 2019
28
[Fibromyalgia syndrome: considerable pain reduction after moving to a "safe site"]. 38
31037342 2019
29
In My Experience: How Educators Can Support a Medical Student With Mental Illness. 38
31425192 2019
30
Galanin Administration into the Prelimbic Cortex Impairs Consolidation and Expression of Contextual Fear Conditioning. 38
31434003 2019
31
The Buffering Effect of Relationships on Combat Exposure, Military Performance, and Mental Health of U.S. Military Soldiers: A Vantage Point for CFTs. 38
31436335 2019
32
Traumatic experiences, mental health, social support and demographics as correlates of alcohol dependence in a sample of Lithuanian police officers. 38
31401847 2019
33
Associations of fatigue and sleep disturbance with nine common mental disorders. 38
31376877 2019
34
Prevalence of intimate partner violence victimization and its association with mental disorders in the Korean general population. 38
31377864 2019
35
Trends and factors in antipsychotic use of outpatients with anxiety disorders in Taiwan, 2005-2013: A population-based study. 38
31077503 2019
36
Pre- to post-inpatient treatment of subjective sleep quality in 5,481 patients with mental disorders: A longitudinal analysis. 38
30907038 2019
37
Lower cortisol levels and attenuated cortisol reactivity to daily-life stressors in adults with 22q11.2 deletion syndrome. 38
30959234 2019
38
Wilm's tumor 1 promotes memory flexibility. 38
31434897 2019
39
Baseline resting heart rate variability predicts post-traumatic stress disorder treatment outcomes in adults with co-occurring substance use disorders and post-traumatic stress. 38
30968959 2019
40
Demographic and psychiatric correlates of compulsive sexual behaviors in gambling disorder. 38
31416337 2019
41
Partnering with Churches to Conduct a Wide-Scale Health Screening of an Urban, Segregated Community. 38
31399892 2019
42
Potentially traumatic events in youth with and at clinical high risk for psychosis. 38
29575640 2019
43
Animal Models of Traumatic Brain Injury and Assessment of Injury Severity. 38
30603958 2019
44
Regulation of HDAC1 and HDAC2 during consolidation and extinction of fear memory. 38
31108155 2019
45
Corticotropin-Releasing Factor (CRF) circuit modulation of cognition and motivation. 38
31212019 2019
46
Oxytocin and Stress: Neural Mechanisms, Stress-Related Disorders, and Therapeutic Approaches. 38
31400490 2019
47
The "All of Us" study - Non-clinical staff members' experience of performing cardiopulmonary resuscitation in acute care settings. 38
31405626 2019
48
The failing cascade: Comorbid post traumatic stress- and opioid use disorders. 38
31063739 2019
49
Predator-induced fear causes PTSD-like changes in the brains and behaviour of wild animals. 38
31391473 2019
50
Implementing Trauma Screening, Brief Intervention, and Referral to Treatment (T-SBIRT) within Employment Services: A Feasibility Trial. 38
31373008 2019

Variations for Acute Stress Disorder

Expression for Acute Stress Disorder

Search GEO for disease gene expression data for Acute Stress Disorder.

Pathways for Acute Stress Disorder

GO Terms for Acute Stress Disorder

Sources for Acute Stress Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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