Acute Stress Disorder disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACT084 MIFTS: 53	Acute Stress Disorder Categories: Mental diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Acute Stress Disorder

MalaCards integrated aliases for Acute Stress Disorder:

Name: Acute Stress Disorder ¹¹ ¹⁴ ⁷⁵

Stress Disorders, Traumatic, Acute ⁷¹

Stress Disorders, Traumatic ⁷¹

Traumatic Stress Disorder ¹¹

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:6088

ICD9CM ³⁴ 308.3

SNOMED-CT ⁶⁸ 192043003

UMLS ⁷¹ C0029488 C0038441 C0236816

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Summaries for Acute Stress Disorder

Disease Ontology: ¹¹ An anxiety disorder that has symptom flashbacks, has symptom bad dreams, has symptom frightening thoughts, has symptom avoidance or has symptom hyperarousal of PTSD occurring within one month of a traumatic experience as Acute Stress Disorder or ASD.

MalaCards based summary: Acute Stress Disorder, also known as stress disorders, traumatic, acute, is related to multiple personality disorder and sleep apnea, and has symptoms including flashbacks, bad dreams and frightening thoughts. An important gene associated with Acute Stress Disorder is INO80C (INO80 Complex Subunit C), and among its related pathways/superpathways are Signal Transduction and Class A/1 (Rhodopsin-like receptors). The drugs Diazepam and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and amygdala, and related phenotypes are nervous system and homeostasis/metabolism

Wikipedia: ⁷⁵ Acute stress disorder (ASD, also known as acute stress reaction, psychological shock, mental shock, or... more...

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Related Diseases for Acute Stress Disorder

Diseases related to Acute Stress Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 467)

#	Related Disease	Score	Top Affiliating Genes
1	multiple personality disorder	30.9	OXT OGN
2	sleep apnea	30.7	SLC6A4 HTR2A BDNF
3	apnea, obstructive sleep	30.7	POMC HTR2A BDNF
4	psychotic disorder	30.5	SLC6A4 OXT HTR2A GAD2 CRH BDNF
5	headache	30.5	SLC6A4 HTR2A BDNF
6	dissociative amnesia	30.5	OGN FKBP5 CRH BDNF
7	cocaine dependence	30.5	SLC6A4 POMC CRH
8	sleep disorder	30.5	SLC6A4 POMC HTR2A CRH BDNF
9	bulimia nervosa	30.4	SLC6A4 OXT HTR2A BDNF
10	acquired immunodeficiency syndrome	30.3	POMC NR3C1 CRH
11	drug dependence	30.3	SLC6A4 POMC CRH BDNF
12	somatization disorder	30.3	SLC6A4 POMC OXT GAD2 CRH
13	pain agnosia	30.2	POMC OXT CRH BDNF
14	pituitary adenoma	30.2	POMC NR3C1 CRH
15	heroin dependence	30.2	SLC6A4 HTR2A BDNF
16	separation anxiety disorder	30.2	SLC6A4 OXT CRH BDNF
17	amnestic disorder	30.2	OXT OGN BDNF
18	premature ovarian failure 7	30.1	POMC CRH
19	leptin deficiency or dysfunction	30.1	POMC OXT CRH BDNF
20	chronic fatigue syndrome	30.1	SLC6A4 POMC NR3C1 CRH BDNF
21	disease of mental health	30.1	SLC6A4 POMC OXT HTR2A CRHR1 CRH
22	anterograde amnesia	30.1	GAD2 BDNF
23	premature ejaculation	30.1	SLC6A4 OXT BDNF
24	gilles de la tourette syndrome	30.1	SLC6A4 HTR2A BDNF
25	tobacco addiction	30.1	SLC6A4 HTR2A CRHR1 CRH BDNF
26	brunner syndrome	30.1	SLC6A4 HTR2A
27	cannabis abuse	30.1	SLC6A4 BDNF
28	neurotic disorder	30.1	SLC6A4 POMC OXT HTR2A CRH BDNF
29	fibromyalgia	30.1	SLC6A4 POMC OXT HTR2A CRH BDNF
30	retrograde amnesia	30.1	SLC6A4 POMC CRH BDNF
31	paine syndrome	30.0	SLC6A4 POMC CRH BDNF
32	bipolar i disorder	30.0	SLC6A4 HTR2A BDNF
33	paranoid schizophrenia	30.0	SLC6A4 HTR2A BDNF
34	personality disorder	30.0	SLC6A4 NR3C1 HTR2A FKBP5 CRHR2 CRHR1
35	bruxism	30.0	SLC6A4 HTR2A BDNF
36	schizoaffective disorder	30.0	SLC6A4 HTR2A BDNF
37	asperger syndrome	30.0	SLC6A4 OXT BDNF
38	diabetes insipidus	29.9	POMC OXT CRH
39	dissociative disorder	29.9	SLC6A4 OXT OGN HTR2A FKBP5 BDNF
40	amenorrhea	29.9	POMC OXT CRH
41	adult syndrome	29.9	POMC NR3C1 CRH
42	opiate dependence	29.8	SLC6A4 POMC CRHR1 CRH BDNF
43	conduct disorder	29.8	SLC6A4 POMC OXT
44	impulse control disorder	29.8	SLC6A4 HTR2A BDNF
45	intermittent explosive disorder	29.8	SLC6A4 OXT HTR2A
46	borderline personality disorder	29.8	SLC6A4 NR3C1 HTR2A FKBP5 CRHR2 CRHR1
47	serotonin syndrome	29.8	SLC6A4 OXT HTR2A
48	alexithymia	29.8	SLC6A4 PIR OXT HTR2A CRH BDNF
49	migraine with or without aura 1	29.8	SLC6A4 POMC OXT HTR2A CRHR1 CRH
50	narcissistic personality disorder	29.8	PIR OXT

Comorbidity relations with Acute Stress Disorder via Phenotypic Disease Network (PDN):

Anxiety	Hypertension, Essential
Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Acute Stress Disorder:

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Symptoms & Phenotypes for Acute Stress Disorder

Symptoms:

¹¹

• flashbacks
• bad dreams
• frightening thoughts

• avoidance
• hyperarousal of ptsd occurring

UMLS symptoms related to Acute Stress Disorder:

agitation; motor restlessness; acute stress/transient/situational disturbance

GenomeRNAi Phenotypes related to Acute Stress Disorder according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.11	BDNF CRH CRHR1 CRHR2 FAM163A FKBP5
2	no effect	GR00402-S-2	10.11	BDNF CRH CRHR1 CRHR2 FAM163A FKBP5

MGI Mouse Phenotypes related to Acute Stress Disorder:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.11	BDNF CRH CRHR1 FKBP5 GAD2 INO80C
2	homeostasis/metabolism	MP:0005376	10.07	BDNF CRH CRHR1 CRHR2 FAM163A FKBP5
3	growth/size/body region	MP:0005378	9.93	BDNF CRH FAM163A FKBP5 GAD2 INO80C
4	no phenotypic analysis	MP:0003012	9.88	BDNF CRH CRHR1 GAD2 NR3C1 POMC
5	adipose tissue	MP:0005375	9.8	CRH CRHR2 FAM163A NR3C1 OXT POMC
6	endocrine/exocrine gland	MP:0005379	9.7	BDNF CRH CRHR1 CRHR2 GAD2 HTR2A
7	behavior/neurological	MP:0005386	9.44	BDNF CRH CRHR1 CRHR2 FKBP5 GAD2

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Drugs & Therapeutics for Acute Stress Disorder

Drugs for Acute Stress Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 271)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Diazepam

Approved, Illicit, Investigational, Vet_approved

Phase 4

439-14-5

3016

Citalopram

Approved

Phase 4

59729-32-7, 59729-33-8

2771

Ondansetron

Approved, Withdrawn

Phase 4

99614-02-5

4595

Hydromorphone

Approved, Illicit

Phase 4

466-99-9, 71-68-1

5284570

Cycloserine

Approved

Phase 4

68-41-7

6234

Paroxetine

Approved, Investigational

Phase 4

61869-08-7

43815

Atomoxetine

Approved

Phase 4

82248-59-7, 83015-26-3

54841

Memantine

Approved, Investigational

Phase 4

41100-52-1, 19982-08-2

4054

Mifepristone

Approved, Investigational

Phase 4

84371-65-3

55245

Histamine

Approved, Investigational

Phase 4

51-45-6

774

Mianserin

Approved, Investigational

Phase 4

24219-97-4

4184

Levodopa

Approved

Phase 4

59-92-7, 63-84-3

6047

Vortioxetine

Approved, Investigational

Phase 4

508233-74-7

9966051

Naltrexone

Approved, Investigational, Vet_approved

Phase 4

16590-41-3

5360515

Eszopiclone

Approved, Investigational

Phase 4

138729-47-2

969472

Clonazepam

Approved, Illicit

Phase 4

1622-61-3

2802

Oxytocin

Approved, Vet_approved

Phase 4

50-56-6

439302 53477758

Risperidone

Approved, Investigational

Phase 4

106266-06-2

5073

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Mirtazapine

Approved

Phase 4

85650-52-8, 61337-67-5

4205

Asenapine

Approved

Phase 4

85650-56-2, 65576-45-6

163091

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741 5523

Haloperidol

Approved

Phase 4

52-86-8

3559

Carbon monoxide

Approved, Investigational

Phase 4

630-08-0

281

Bupropion

Approved

Phase 4

31677-93-7, 34841-39-9, 34911-55-2

444

Bupivacaine

Approved, Investigational

Phase 4

2180-92-9, 38396-39-3

2474

Diphenhydramine

Approved, Investigational

Phase 4

147-24-0, 58-73-1

3100

Suvorexant

Approved, Investigational

Phase 4

1030377-33-3

57505028 24965990

Promethazine

Approved, Investigational

Phase 4

60-87-7

4927

Pimavanserin

Approved, Investigational

Phase 4

706779-91-1

10071196

Eltanolone

Approved, Investigational

Phase 4

516-54-1, 128-20-1

31402 92786

Propranolol

Approved, Investigational

Phase 4

318-98-9, 525-66-6

62882 4946

Sertraline

Approved

Phase 4

79617-96-2

68617

Prazosin

Approved

Phase 4

19216-56-9

4893

Duloxetine

Approved

Phase 4

136434-34-9, 116539-59-4

60835

Valproic acid

Approved, Investigational

Phase 4

99-66-1

3121

Dexetimide

Withdrawn

Phase 4

21888-98-2

30843

Olive

Phase 4

Analgesics, Opioid

Phase 4

Narcotics

Phase 4

Pharmaceutical Solutions

Phase 4

Antiemetics

Phase 4

Gastrointestinal Agents

Phase 4

Anti-Bacterial Agents

Phase 4

Anti-Infective Agents

Phase 4

Antimetabolites

Phase 4

Antitubercular Agents

Phase 4

Antibiotics, Antitubercular

Phase 4

Quetiapine Fumarate

Phase 4

111974-72-2

Contraceptives, Postcoital

Phase 4

Interventional clinical trials:

(show top 50) (show all 1243)

#	Name	Status	NCT ID	Phase	Drugs
1	Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure	Unknown status	NCT00633685	Phase 4	Fluoxetine;Placebo
2	A Prospective Double Blind Randomized Placebo Controlled Trial of Repetitive Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder	Unknown status	NCT00134446	Phase 4
3	Double Blind, Placebo-Controlled Trial of THC as add-on Therapy for PTSD	Unknown status	NCT00965809	Phase 4	Tetrahydrocannabinol
4	The Effect of 21-Days Intranasal Oxytocin on Clinical Symptoms and Social Function in Patients With Post Traumatic Stress Disorder (PTSD), a Randomized Controled Trail	Unknown status	NCT02336568	Phase 4	Oxytoine;PLACEBO
5	Early Pharmacological Intervention With Diazepam in the Emergency Room Setting to Prevent Posttraumatic Stress Disorder (PTSD).	Unknown status	NCT01221883	Phase 4	Diazepam
6	A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder	Unknown status	NCT01535586	Phase 4
7	Efficacy of an SSRI in Acute Stress Disorder and PTSD	Completed	NCT00050804	Phase 4	sertraline
8	Evaluation of the Effects of Low Flow Anesthesia on Pain and Agitation in Patients After Recovery	Completed	NCT03862391	Phase 4	Analgesics;Antiemetics
9	The Effect of Different Dose of Dexmedetomidine Combined With Hydromorphone in Children With Tonsillectomy and Adenoidectomy	Completed	NCT03760809	Phase 4	Dexmedetomidine 0.5μg／kg;Dexmedetomidine 1μg／kg
10	Effects of Hydrocortisone and D-Cycloserine on Fear Extinction in Veterans With Posttraumatic Stress Disorder	Completed	NCT00674570	Phase 4	Hydrocortisone;D-Cycloserine;Placebo
11	Atomoxetine in Comorbid ADHD/PTSD: A Pilot, Placebo-Controlled Feasibility Study	Completed	NCT02287038	Phase 4	Atomoxetine 80 MG
12	An Open-Label Trial of Memantine for Cognitive Impairment in Patients With Post-Traumatic Stress Disorder	Completed	NCT02258828	Phase 4	Memantine;Placebo
13	Effects of Paxil CR on Neural Circuits in PTSD	Completed	NCT00672776	Phase 4	paroxetine;placebo
14	A Pilot Study to Assess the Effects of Doxazosin on Polysomnography in PTSD	Completed	NCT01959022	Phase 4	Doxazosin XL
15	Pilot Feasibility Study of Pimavanserin for Insomnia in Veterans With Posttraumatic Stress Disorder	Completed	NCT04188392	Phase 4	Pimavanserin
16	Treatment of Sleep Disturbances in Trauma-affected Refugees: A Randomised Controlled Trial	Completed	NCT02761161	Phase 4	Mianserin
17	A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol	Completed	NCT00709735	Phase 4	Propranolol;Placebo
18	Neurofunctional Markers of SSRI Treatment Response in PTSD	Completed	NCT00700999	Phase 4	Paroxetine
19	Evaluation of the Efficacy of Vortioxetine for Posttraumatic Stress Disorder	Completed	NCT02637895	Phase 4	Placebo;Vortioxetine
20	Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753)	Completed	NCT02560389	Phase 4	Placebo;Levodopa
21	Randomized Clinical Trial to Study the Topiramate Efficacy for Posttraumatic Disorder Treatment	Completed	NCT00725920	Phase 4	Topiramate;placebo control group
22	Retrospective Review of Ketamine Assisted Psychotherapy Program on Mental Health at Field Trip Health Centres in North America	Completed	NCT05604794	Phase 4
23	Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder	Completed	NCT00120250	Phase 4	Eszopiclone
24	Combined Treatment With a Benzodiazepine (Clonazepam) and a Selective Serotonin Reuptake Inhibitor (Paroxetine) for Rapid Treatment of Posttraumatic Stress Disorder (PTSD)	Completed	NCT00025740	Phase 4	clonazepam and paroxetine
25	Prophylaxis of Posttraumatic Stress Disorder With Post-Trauma Propranolol	Completed	NCT00158262	Phase 4	Propranolol;Placebo
26	Secondary Prevention With Paroxetine vs. Placebo in Subthreshold Posttraumatic Stress Disorder (PTSD)	Completed	NCT00560612	Phase 4	Paroxetine;Placebo
27	A Study of Sertraline to Prevent PTSD	Completed	NCT00182078	Phase 4	Placebo;Sertraline
28	Treatment for Psychogenic Nonepileptic Seizures: A Pilot, 12 Week, Prospective, Randomized, Placebo-controlled, Double-blind, Clinical Trial of Sertraline in the Treatment of Comorbid Psychiatric Disorders in NES	Completed	NCT00159965	Phase 4	sertraline;placebo
29	Prazosin Treatment for Combat Trauma PTSD Nightmares and Sleep Disturbance	Completed	NCT00108420	Phase 4	Prazosin
30	Naltrexone and Cognitive-Behavioral Therapy for Patients With Alcoholism and Post-Traumatic Stress Disorder	Completed	NCT00006489	Phase 4	Naltrexone;Placebo
31	Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy	Completed	NCT01087736	Phase 4	Topiramate
32	Eszopiclone for the Treatment of PTSD	Completed	NCT01605253	Phase 4	Eszopiclone;Placebo
33	A Placebo-controlled, Randomized, Double-blind Comparison of Placebo vs Short Course Low Dose Corticosteroids on Posttraumatic Stress Disorder (PTSD)	Completed	NCT00204737	Phase 4	prednisone;placebo
34	Geodon (Ziprasidone) for Posttraumatic Stress Disorder	Completed	NCT00208208	Phase 4	Ziprasidone
35	Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD)	Completed	NCT00203463	Phase 4	topiramate
36	12 Week Prospective Double Blind Placebo Controlled Randomized Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety	Completed	NCT00352469	Phase 4	Seroquel XR
37	Coordinated Anxiety Learning and Management (CALM): Improving Primary Care Anxiety Outcomes	Completed	NCT00347269	Phase 4	Psychotropic medication optimization
38	A Placebo-controlled Trial of Adjunctive Quetiapine for Refractory PTSD	Completed	NCT00292370	Phase 4	Open Label (OL) Paroxetine;Placebo;Quetiapine
39	A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Posttraumatic Stress Disorder in Civilians	Completed	NCT00208130	Phase 4	Topiramate
40	Risperidone Monotherapy in the Treatment of PTSD in Women Survivors of Domestic Abuse and Rape Trauma: a Double-Blind, Placebo Controlled, Randomized Clinical Trial	Completed	NCT00208182	Phase 4	Risperidone
41	Psychophysiology of Delayed Extinction and Reconsolidation in Humans	Completed	NCT01631682	Phase 4	Propranolol;Mifepristone;Intranasal oxytocin
42	The Outcome of Treatment of Traumatised Refugees With Trauma-Focused Cognitive Behavioural Therapy and / or Antidepressants - a Randomised Controlled Trial	Completed	NCT00917397	Phase 4	Sertraline
43	Combination Treatment for PTSD After the WTC Attack	Completed	NCT01130103	Phase 4	Paroxetine
44	Developing Memory Reconsolidation Blockers as Novel PTSD Treatments	Completed	NCT01490697	Phase 4	Mifepristone;d-Cycloserine;Placebo-matching Mifepristone;Placebo-matching d-Cycloserine (DCS)
45	Effects of Escitalopram on Autonomic Reactivity in Post Traumatic Stress Disorder Among Veterans of Operation Enduring Freedom and Iraqi Freedom (OEF/OIF)	Completed	NCT01271244	Phase 4	Escitalopram
46	Can Blocking the Orexin System Enhance Sleep's Benefits to Therapeutic Exposure for PTSD?	Completed	NCT02849548	Phase 4	suvorexant
47	The Treatment of Traumatised Refugees With Sertraline Versus Venlafaxine in Combination With Psychotherapy - a Randomised Clinical Study	Completed	NCT01569685	Phase 4	Venlafaxine;Sertraline
48	Combined Mirtazapine and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment of Post-traumatic Stress Disorder (PTSD)	Completed	NCT01178671	Phase 4	Mirtazapine;Sertraline
49	The Effect of Intranasal Oxytocin on Emphatic Abilities in Patients With PTSD	Completed	NCT01325168	Phase 4	syntocinon nasal spray;placebo nasal spray
50	Reducing Suicidal Ideation Through Treatment of Nightmares-PTSD	Completed	NCT02199652	Phase 4	Prazosin;Placebo

Search NIH Clinical Center for Acute Stress Disorder

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Genetic Tests for Acute Stress Disorder

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Anatomical Context for Acute Stress Disorder

Organs/tissues related to Acute Stress Disorder:

MalaCards : Brain, Prefrontal Cortex, Amygdala, Eye, Spinal Cord, Cortex, Temporal Lobe

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Publications for Acute Stress Disorder

Articles related to Acute Stress Disorder:

(show top 50) (show all 15022)

#	Title	Authors	PMID	Year
1	Neuronal nitric oxide synthase inhibition accelerated the removal of fluoxetine's anxiogenic activity in an animal model of PTSD. ⁶²	Sadeghi MA...Chamanara M	36174841	2023
2	Mental health indicators in Sweden over a 12-month period during the COVID-19 pandemic - Baseline data of the Omtanke2020 Study. ⁶²	Lovik A...Fang F	36379324	2023
3	Internet-delivered psychological treatment as an add-on to treatment as usual for common mental disorders: A systematic review with meta-analysis of randomized trials. ⁶²	Jonsson U...Arnberg FK	36400149	2023
4	Negative emotion-conditioned prepulse induces the attentional enhancement of prepulse inhibition in humans. ⁶²	Yang X...Li L	36330905	2023
5	Work Harassment and Resource Loss Among (Ex)partner Stalking Victims. ⁶²	Logan TK...Showalter K	35549528	2023
6	Melancholic features and typical neurovegetative symptoms of major depressive disorder show specific polygenic patterns. ⁶²	Oliva V...Serretti A	36216191	2023
7	Transcranial Magnetic Stimulation and its Imaging Features in Patients With Depression, Post-traumatic Stress Disorder, and Traumatic Brain Injury. ⁶²	Huntley JH...Yousem DM	35437218	2023
8	The Safety and Efficacy of Psychedelic-Assisted Therapies for Older Adults: Knowns and Unknowns. ⁶²	Johnston CB...Anderson B	36184377	2023
9	Hyper-Sensitivity to the Perpetrator and the Likelihood of Returning to Abusive Relationships. ⁶²	Lahav Y	35499214	2023
10	Psychological consequences and daily life adjustment for victims of intimate partner violence. ⁶²	Cirici Amell R...Soldevilla Alberti JM	35393871	2023
11	Stress resilience-associated behaviors following predator scent stress are accompanied by upregulated nucleus accumbens mGlu5 transcription in female Sprague Dawley rats. ⁶²	Blount HL...Knackstedt LA	36057378	2023
12	Child Maltreatment and Psychiatric Disorders Increase Risk for Stalking Victimization. ⁶²	Bonagura AG...Widom CS	35236175	2023
13	Trajectories of Depression, Post-Traumatic Stress, and Chronic Pain Among Women Who Have Separated From an Abusive Partner: A Longitudinal Analysis. ⁶²	Ford-Gilboe M...Perrin N	35512192	2023
14	Prevalence of common mental health disorders in forcibly displaced populations versus labor migrants by migration phase: A meta-analysis. ⁶²	Carroll HA...Bird M	36367496	2023
15	Post-traumatic Stress Disorder. ⁶²	Merians AN...Pietrzak RH	36402502	2023
16	Longitudinal impact of the COVID19 pandemic on mental health in a general population sample in France: Evidence from the COMET Study. ⁶²	Moulin F...Galera C	36191642	2023
17	Beyond Viral Suppression-The Impact of Cumulative Violence on Health-Related Quality of Life Among a Cohort of Virally Suppressed Patients. ⁶²	Harris RM...Wong FY	36099083	2023
18	Gut microbiota alterations promote traumatic stress susceptibility associated with p-cresol-induced dopaminergic dysfunctions. ⁶²	Laudani S...Leggio GM	36400332	2023
19	Fear extinction induced by activation of PKA ameliorates anxiety-like behavior in PTSD mice. ⁶²	Gao F...Zhu G	36341808	2023
20	Actigraphic sleep monitoring in patients with post-traumatic stress disorder (PTSD): A meta-analysis. ⁶²	Lam L...Chung KF	36174789	2023
21	Imagery re-scripting for PTSD: session content and its relation to symptom improvement. ⁶²	Brown G...Wheatley J	36258276	2023
22	Burnout and post-traumatic stress disorder symptoms among medical staff two years after the COVID-19 pandemic in Wuhan, China: Social support and resilience as mediators. ⁶²	Liu Y...Fu W	36280200	2023
23	Mode of birth and development of maternal postnatal post-traumatic stress disorder: A mixed-methods systematic review and meta-analysis. ⁶²	Carter J...Chang YS	35561055	2022
24	The brain at rest: Exploratory Neurophysiological Findings Among Men With Histories of Childhood Sexual Abuse. ⁶²	Chiasson C...Smith A	36439659	2022
25	Psychiatric Outcomes of Childhood Maltreatment: A Retrospective Chart Review from a Children's Psychiatric Inpatient Program. ⁶²	Cancilliere MK...Holler K	34156637	2022
26	Treatment efficacy of tDCS and predictors of treatment response in patients with post-traumatic stress disorder. ⁶²	Han J...Lee SH	36055537	2022
27	Sleep Latency and Post-Traumatic Stress Disorder Among Retired Career Florida Firefighters: Evidence From the Advancing Epidemiology of Retired Firefighters Aging Longitudinally Cohort. ⁶²	Testoff AC...Caban-Martinez AJ	36221257	2022
28	Comparing Trauma Treatment Outcomes Between Homeless and Housed Veterans in a VA PTSD Clinical Program. ⁶²	Crone B...Carlin E	36459286	2022
29	MDMA administration attenuates hippocampal IL-β immunoreactivity and subsequent stress-enhanced fear learning: An animal model of PTSD. ⁶²	Parekh SV...Lysle DT	36388136	2022
30	Factors influencing participation in psychosocial programming among orthopaedic trauma patients with PTSD. ⁶²	Furdock RJ...Vallier HA	36184361	2022
31	Prevalence and sociocultural correlates of post-traumatic stress disorder and complex PTSD among Chinese community health service users in Hong Kong. ⁶²	Fung HW...Cloitre M	36457219	2022
32	Activation of ventral tegmental area dopaminergic neurons ameliorates anxiety-like behaviors in single prolonged stress-induced PTSD model rats. ⁶²	Guan P...Zhang C	36228742	2022
33	Sex differences in the effect of subjective sleep on fear conditioning, extinction learning, and extinction recall in individuals with a range of PTSD symptom severity. ⁶²	Schenker MT...Felmingham KL	36327524	2022
34	Posttraumatic stress disorder, cardiovascular disease outcomes and the modifying role of socioeconomic status. ⁶²	Kim K...Jung SJ	36174781	2022
35	Cardiovascular events in insomnia patients with post-traumatic stress disorder. ⁶²	El-Solh AA...Attai P	35994935	2022
36	"When I am breathless now, I don't have the fear that's linked to it": a case series on the potential of EMDR to break the dyspnea-anxiety cycle in COPD. ⁶²	Mooren K...Godschalx J	36451139	2022
37	Corticotropin releasing factor in the nucleus basalis of Meynert impairs attentional performance and reduces levels of glutamate and taurine in male and female rats. ⁶²	Eck SR...Bangasser DA	36216029	2022
38	Thoughts of suicide or self-harm among Australian healthcare workers during the COVID-19 pandemic. ⁶²	Bismark M...Smallwood N	35128948	2022
39	Effects of low doses of different nitric oxide (NO) donors in rat models of obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). ⁶²	Peristeri E...Pitsikas N	36084795	2022
40	Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments. ⁶²	Stankiewicz AM...Juszczak GR	35405299	2022
41	Can Women Shelters Help Reduce Symptoms of PTSD and C-PTSD? Trajectories of PTSD Symptom Development Following Partner- and Family-Related Violence. ⁶²	Dokkedahl S...Elklit A	34986313	2022
42	Depression, anxiety, and post-traumatic stress disorder symptoms after hyperemesis gravidarum: a prospective cohort study. ⁶²	Nijsten K...Painter RC	35726837	2022
43	Posttraumatic stress disorder strengthens the momentary associations between emotion dysregulation and substance use: a micro-longitudinal study of community women experiencing intimate partner violence. ⁶²	Weiss NH...Sullivan TP	35792057	2022
44	Landslide disasters in eastern Uganda: post-traumatic stress disorder and its correlates among survivors in Bududa district. ⁶²	Kabunga A...Apili B	36471406	2022
45	[A longitudinal study about post-traumatic stress disorder after delivery in Tunisian primiparous]. ⁶²	Chakroun M...Aloulou J	34801230	2022
46	Psychosocial aspects of coping that predict post-traumatic stress disorder for African American survivors of homicide victims. ⁶²	Sharpe TL...Iwamoto DK	36162488	2022
47	The association of mindfulness and psychological well-being among individuals who have recovered from COVID-19 in Jianghan District, Wuhan, China: A cross-sectional study. ⁶²	Dai Z...Su X	36162667	2022
48	Post-pandemic stress of COVID-19 among high-risk groups: A systematic review and meta-analysis. ⁶²	Bajoulvand R...Imani-Nasab MH	36174783	2022
49	Evidence for the beneficial effect of ketamine in the treatment of patients with post-traumatic stress disorder: A systematic review and meta-analysis. ⁶²	Albuquerque TR...Menezes IRA	35891578	2022
50	Screening tools for post-intensive care syndrome and post-traumatic symptoms in intensive care unit survivors: A scoping review. ⁶²	Pant U...Papathanassoglou E	36464526	2022

Sources

Genes for Acute Stress Disorder

Genes related to Acute Stress Disorder (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	INO80C	INO80 Complex Subunit C	Protein Coding	7.3	DISEASES inferred ¹⁴
2	FKBP5	FKBP Prolyl Isomerase 5	Protein Coding	6	DISEASES inferred ¹⁴
3	CRH	Corticotropin Releasing Hormone	Protein Coding	5.72	DISEASES inferred ¹⁴
4	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	5.63	DISEASES inferred ¹⁴
5	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	5.56	DISEASES inferred ¹⁴
6	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	5.54	DISEASES inferred ¹⁴
7	CRHR1	Corticotropin Releasing Hormone Receptor 1	Protein Coding	5.38	DISEASES inferred ¹⁴
8	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	5.32	DISEASES inferred ¹⁴
9	GAD2	Glutamate Decarboxylase 2	Protein Coding	5.31	DISEASES inferred ¹⁴
10	OGN	Osteoglycin	Protein Coding	5.22	DISEASES inferred ¹⁴
11	SARS2	Seryl-TRNA Synthetase 2, Mitochondrial	Protein Coding	5.13	DISEASES inferred ¹⁴
12	POMC	Proopiomelanocortin	Protein Coding	5.12	DISEASES inferred ¹⁴
13	PTGIS	Prostaglandin I2 Synthase	Protein Coding	5.05	DISEASES inferred ¹⁴
14	FAM163A	Family With Sequence Similarity 163 Member A	Protein Coding	4.84	DISEASES inferred ¹⁴
15	HTR2A	5-Hydroxytryptamine Receptor 2A	Protein Coding	4.83	DISEASES inferred ¹⁴
16	PIR	Pirin	Protein Coding	4.8	DISEASES inferred ¹⁴
17	CRHR2	Corticotropin Releasing Hormone Receptor 2	Protein Coding	4.78	DISEASES inferred ¹⁴

Sources

Variations for Acute Stress Disorder

Sources

Expression for Acute Stress Disorder

Search GEO for disease gene expression data for Acute Stress Disorder.

Sources

Pathways for Acute Stress Disorder

Pathways related to Acute Stress Disorder according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	13.47	BDNF CRH CRHR1 CRHR2 FKBP5 HTR2A
2	Class A/1 (Rhodopsin-like receptors) ⁶⁶ Show member pathways GPCR ligand binding ⁶⁶ GPCRs, class A rhodopsin-like ⁷⁴ Peptide GPCRs ⁷⁴ Peptide ligand-binding receptors ⁶⁶	13.1	POMC OXT HTR2A CRHR2 CRHR1 CRH
3	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴	12.35	POMC CRHR2 CRHR1 CRH BDNF
4	Transcriptional Regulation by MECP2 ⁶⁶ Show member pathways Competing endogenous RNAs (ceRNAs) regulate PTEN translation ⁶⁶ Disorders of Developmental Biology ⁶⁶ Disorders of Nervous System Development ⁶⁶ Loss of function of MECP2 in Rett syndrome ⁶⁶ Loss of MECP2 binding ability to 5hmC-DNA ⁶⁶ Loss of MECP2 binding ability to 5mC-DNA ⁶⁶ Loss of MECP2 binding ability to the NCoR/SMRT complex ⁶⁶ Loss of phosphorylation of MECP2 at T308 ⁶⁶ MECP2 regulates neuronal receptors and channels ⁶⁶ MECP2 regulates transcription factors ⁶⁶ MECP2 regulates transcription of genes involved in GABA signaling ⁶⁶ MECP2 regulates transcription of neuronal ligands ⁶⁶ Pervasive developmental disorders ⁶⁶ Post-transcriptional silencing by small RNAs ⁶⁶ PTEN Loss of Function in Cancer ⁶⁶ Regulation of MECP2 expression and activity ⁶⁶ Regulation of PTEN mRNA translation ⁶⁶	12.11	GAD2 FKBP5 CRH BDNF
5	G alpha (s) signalling events ⁶⁶ Show member pathways Defective ACTH causes obesity and POMCD ⁶⁶	11.83	POMC CRHR2 CRHR1 CRH
6	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	11.76	SLC6A4 NR3C1 HTR2A BDNF
7	Glucocorticoid receptor regulatory network ⁶¹	11.54	POMC NR3C1 FKBP5
8	Corticotropin-releasing hormone signaling pathway ⁷⁴	11.42	POMC CRHR2 CRHR1 CRH
9	Prader-Willi and Angelman syndrome ⁷⁴	11.39	POMC OXT BDNF
10	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶⁰	10.97	SLC6A4 HTR2A
11	GPCRs, class B secretin-like ⁷⁴	10.87	CRHR2 CRHR1
12	Serotonin and anxiety ⁷⁴ Show member pathways Serotonin and anxiety-related events ⁷⁴	10.72	POMC HTR2A CRHR1 CRH
13	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶⁰	9.77	POMC CRHR2 CRHR1 CRH

Sources

GO Terms for Acute Stress Disorder

Biological processes related to Acute Stress Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.21	BDNF CRH CRHR1 CRHR2 HTR2A NR3C1
2	female pregnancy	GO:0007565	9.95	OXT CRHR1 CRH
3	maternal behavior	GO:0042711	9.76	OXT NR3C1
4	sleep	GO:0030431	9.73	OXT HTR2A
5	parturition	GO:0007567	9.71	CRHR1 CRH
6	adrenal gland development	GO:0030325	9.63	NR3C1 CRHR1 CRH
7	sperm ejaculation	GO:0042713	9.62	SLC6A4 OXT
8	cellular response to corticotropin-releasing hormone stimulus	GO:0071376	9.56	CRHR2 CRHR1
9	regulation of corticosterone secretion	GO:2000852	9.26	POMC CRHR1
10	memory	GO:0007613	9.23	SLC6A4 OXT HTR2A BDNF

Molecular functions related to Acute Stress Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serotonin binding	GO:0051378	9.46	SLC6A4 HTR2A
2	corticotropin-releasing hormone receptor activity	GO:0043404	9.26	CRHR2 CRHR1
3	corticotrophin-releasing factor receptor activity	GO:0015056	8.92	CRHR2 CRHR1