MCID: ACT053
MIFTS: 28

Acute Thyroiditis

Categories: Endocrine diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Acute Thyroiditis

MalaCards integrated aliases for Acute Thyroiditis:

Name: Acute Thyroiditis 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:14353
ICD9CM 34 245.0
SNOMED-CT 67 154665005
ICD10 32 E06.0
UMLS 71 C0001360

Summaries for Acute Thyroiditis

MalaCards based summary : Acute Thyroiditis is related to thyroiditis and suppurative thyroiditis. An important gene associated with Acute Thyroiditis is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Amine-derived hormones. The drug Bevacizumab has been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and breast.

Related Diseases for Acute Thyroiditis

Diseases in the Thyroiditis family:

Acute Thyroiditis Subacute Thyroiditis

Diseases related to Acute Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 thyroiditis 30.5 TPO TG SERPINA7 CALCA
2 suppurative thyroiditis 30.4 TPO TG CALCA
3 subacute thyroiditis 29.9 TPO TG SERPINA7
4 graves disease 1 29.6 TPO TG SERPINA7 CALCA
5 thyroid crisis 29.5 TPO TG SERPINA7
6 myxedema 29.5 TPO TG SERPINA7
7 thyroid carcinoma 29.4 TPO TG CALCA
8 thyroid gland anaplastic carcinoma 29.4 TPO TG CALCA
9 hyperthyroidism 29.3 TPO TG SERPINA7 CALCA
10 graves' disease 29.2 TPO TG SERPINA7 ATP5PO
11 thyroid gland disease 28.6 TPO TG SERPINA7 IYD CALCA
12 hypothyroidism 28.6 TPO TG SERPINA7 IYD CALCA
13 mechanical strabismus 10.2 TPO TG
14 iodine hypothyroidism 10.2 TPO TG
15 aspirin allergy 10.2 TPO TG
16 postsurgical hypothyroidism 10.2 TPO TG
17 breast cystic hypersecretory carcinoma 10.2 TG LALBA
18 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.2 TPO TG
19 subacute lymphocytic thyroiditis 10.2 TPO TG
20 hypotropia 10.2 TPO ATP5PO
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 TPO TG
22 type 1 diabetes mellitus 20 10.1 TPO TG
23 adrenal cortical hypofunction 10.1 TPO TG
24 pernicious anemia 10.1 TPO TG
25 exophthalmos 10.1 TPO TG
26 adrenal cortex disease 10.1 TPO TG
27 thyroid gland mucoepidermoid carcinoma 10.1 TG CALCA
28 spindle epithelial tumor with thymus-like differentiation tumor 10.1 TG CALCA
29 isthmus cancer 10.1 TG CALCA
30 euthyroid sick syndrome 10.1 TG SERPINA7
31 substernal goiter 10.1 TG CALCA
32 atypical follicular adenoma 10.1 TG CALCA
33 thyroid sarcoma 10.1 TG CALCA
34 carotid body cancer 10.1 TG CALCA
35 thyroid hormone resistance, generalized, autosomal dominant 10.1 TG SERPINA7
36 fetal adenoma 10.1 TG CALCA
37 hypoadrenocorticism, familial 10.1 TPO TG
38 epithelial malignant thymoma 10.1 TG CALCA
39 hypothyroidism, congenital, nongoitrous, 1 10.1 TG IYD
40 chronic urticaria 10.1 TPO TG
41 ectopic thymus 10.1 TG CALCA
42 thyroid angiosarcoma 10.1 TG CALCA
43 nasal cavity olfactory neuroblastoma 10.0 TG CALCA
44 autoimmune polyendocrine syndrome 10.0 TPO TG
45 uterus leiomyosarcoma 10.0 TG CALCA
46 papillary thyroid microcarcinoma 10.0 TG CALCA
47 basilar artery insufficiency 10.0 TPO CALCA
48 hyperthyroxinemia 10.0 TPO SERPINA7
49 hyperparathyroidism 10.0
50 thyroid gland medullary carcinoma 10.0 TG CALCA

Graphical network of the top 20 diseases related to Acute Thyroiditis:



Diseases related to Acute Thyroiditis

Symptoms & Phenotypes for Acute Thyroiditis

Drugs & Therapeutics for Acute Thyroiditis

Drugs for Acute Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anti-VEGF Therapy for Acute Thyroid Eye Disease (AcTED Study) Not yet recruiting NCT04311606 Phase 2 Sub-tenon injection of saline followed by a sub-tenon injection of aflibercept;Sub-tenon injection of hyaluronidase (HA) followed by a sub-tenon injection of aflibercept;Sub-tenon injection of hyaluronidase (HA) alone

Search NIH Clinical Center for Acute Thyroiditis

Genetic Tests for Acute Thyroiditis

Anatomical Context for Acute Thyroiditis

MalaCards organs/tissues related to Acute Thyroiditis:

40
Thyroid, Eye, Breast, Kidney

Publications for Acute Thyroiditis

Articles related to Acute Thyroiditis:

(show top 50) (show all 163)
# Title Authors PMID Year
1
Thiocyanate in excess develops goiter followed by auto immune thyroid diseases even after effective salt iodization in a rural community of north east India. 61
33396042 2021
2
Subacute thyroiditis presenting with creeping in a 6-year-old boy. 61
33446958 2021
3
Two Different Tracts and Origin of Pyriform Sinus Fistula. 61
33084367 2020
4
[Thyroiditis: What's new in 2019?] 61
32107053 2020
5
PLATELET-LYMPHOCYTE RATIO (PLR) AS A NOVEL SURROGATE MARKER TO DIFFERENTIATE THYROTOXIC PATIENTS WITH GRAVES' DISEASE (GD) FROM SUB-ACUTE THYROIDITIS (SAT): A CROSS-SECTIONAL STUDY FROM SOUTH INDIA. 61
32407659 2020
6
ASIA syndrome and endocrine autoimmune disorders. 61
32265102 2020
7
Acute suppurative thyroiditis with thyroid abscess in adults: clinical presentation, treatment and outcomes. 61
31791298 2019
8
Differences in the diagnosis and management of pyriform sinus fistula between newborns and children. 61
31811210 2019
9
Acute Thyroiditis Associated with Brucellosis: A Case Report. 61
31605594 2019
10
Issues in amiodarone-induced thyrotoxicosis: Update and review of the literature. 61
30236455 2019
11
Technetium-99m Thyroid Scintigraphy and Human Leukocyte Antigen - B35 in Sub-Acute Thyroiditis. 61
30386052 2018
12
Thyroid hormones affect nitrergic innervation function in rat mesenteric artery: Role of the PI3K/AKT pathway. 61
29751093 2018
13
Acute Suppurative Thyroiditis with Thyroid Abscess by Klebsiella pneumoniae: An Unusual Presentation. 61
30186015 2018
14
Painful acute thyroiditis following a first cure of Ipilimumab plus Nivolumab for metastatic melanoma. 61
29916989 2018
15
Graves' Disease Presenting as Painful Goiter: A Case Report and Review of the Literature. 61
30101044 2018
16
Acute inflammatory thyromegaly following checkpoint inhibition: A new imaging entity? 61
29552247 2018
17
Painful Hashimoto's thyroiditis: myth or reality? 61
28337674 2017
18
Acute thyroiditis: An under-recognized complication of parathyroidectomy in end-stage renal failure patients with secondary hyperparathyroidism. 61
28621009 2017
19
Pattern of Thyroid Disorders in Children and Adolescents Seen at the Lagos University Teaching Hospital, Nigeria, Over a 10-year Period. 61
29962651 2017
20
[Clinical characteristics and surgical management in patients with third and fourth branchial anomalies]. 61
29798329 2016
21
Mesenteric Vasculitis in a Case of Systemic Lupus Erythematosus. 61
27759348 2016
22
Extra-hepatic replication and infection of hepatitis E virus in neuronal-derived cells. 61
26891712 2016
23
Giant thyroid abscess related to postpartum Brucella infection. 61
25861492 2015
24
Thyrotoxicosis followed by Hypothyroidism due to Suppurative Thyroiditis Caused by Nocardia brasiliensis in a Patient with Advanced Acquired Immunodeficiency Syndrome. 61
24847469 2014
25
[Sub-acute thyroiditis in a patient on immunosuppressive treatment]. 61
24042429 2013
26
Successful treatment of acute thyroiditis due to Aspergillus spp. in the context of disseminated invasive aspergillosis in a kidney transplant patient. 61
23897207 2013
27
Significant role of serum CRP in differentiating inflammatory from non-inflammatory causes of thyrotoxicosis. 61
23226645 2012
28
Primary tuberculosis of the thyroid gland: a case report. 61
23569858 2012
29
[Acute suppurative thyroiditis with multiple complications]. 61
22990644 2012
30
Hashimoto's thyroiditis presenting as acute painful thyroiditis and as a manifestation of an immune reconstitution inflammatory syndrome in a human immunodeficiency virus-seropositive patient. 61
22784301 2012
31
Reversible recurrent laryngeal nerve palsy in acute thyroiditis. 61
22584984 2012
32
The role of sonoelastography in acute, subacute and chronic thyroiditis: a novel application of the method. 61
22143319 2012
33
Acute thyroiditis complicating parathyroidectomy. 61
20224309 2010
34
Unilateral hypopharyngitis, cellulitis, and a multinodular goiter: a triad of findings suggestive of acute suppurative thyroiditis. 61
19461065 2009
35
[Acute thyroiditis due to actinomyces]. 61
19604735 2009
36
[Acute thyroiditis and cervical abscesses as manifestations of the pyriform sinus fistulae]. 61
19957866 2009
37
Acute suppurative thyroiditis as the initial presentation of juvenile systemic lupus erythematosus. 61
19554814 2009
38
A Case of Concurrent Riedel's, Hashimoto's and Acute Suppurative Thyroiditis. 61
19724638 2009
39
Acute thyroiditis due to septic emboli derived from infective endocarditis. 61
18832408 2008
40
[Atypical form of acute suppurative thyroiditis in pediatric patient: case report]. 61
18604385 2008
41
Acute blastomycosis thyroiditis. 61
18578618 2008
42
Acute thyroiditis of odontogenic origin. 61
17938625 2007
43
[Neck pain and fever after peginterferon alpha-2a]. 61
17330412 2007
44
Thyroid imaging in children. 61
17684389 2007
45
[Ultrasound study in the differential diagnosis of thyroid focal lesions of various origin]. 61
18274138 2007
46
Thyroid tuberculosis. 61
17324921 2007
47
Acute thyroiditis of actinomycosis. 61
16405415 2005
48
[Thyroiditis: an approach for the practitioner]. 61
15786648 2005
49
Massive thyroid tumoral embolism from a breast carcinoma presenting as acute thyroiditis. 61
15214816 2004
50
Suppurative thyroiditis with gas formation. 61
12925295 2003

Variations for Acute Thyroiditis

Expression for Acute Thyroiditis

Search GEO for disease gene expression data for Acute Thyroiditis.

Pathways for Acute Thyroiditis

GO Terms for Acute Thyroiditis

Cellular components related to Acute Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 TG SERPINA7 PIP LALBA CALCA
2 extracellular space GO:0005615 9.1 TPO TG SERPINA7 PIP LALBA CALCA

Biological processes related to Acute Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.26 TPO IYD
2 hormone biosynthetic process GO:0042446 9.16 TPO TG
3 thyroid hormone metabolic process GO:0042403 8.96 TG IYD
4 thyroid hormone generation GO:0006590 8.8 TPO TG IYD

Molecular functions related to Acute Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iodide peroxidase activity GO:0004447 8.62 TPO IYD

Sources for Acute Thyroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....