MCID: ACT159
MIFTS: 45

Acute Transverse Myelitis

Categories: Immune diseases, Infectious diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Transverse Myelitis

MalaCards integrated aliases for Acute Transverse Myelitis:

Name: Acute Transverse Myelitis 60
Myelitis, Acute Transverse 74

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 G37.3
UMLS via Orphanet 75 C0270627
Orphanet 60 ORPHA139417
UMLS 74 C0270627

Summaries for Acute Transverse Myelitis

MalaCards based summary : Acute Transverse Myelitis, also known as myelitis, acute transverse, is related to myelitis and lyme disease. An important gene associated with Acute Transverse Myelitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and thyroid, and related phenotypes are cardiovascular system and neoplasm

Related Diseases for Acute Transverse Myelitis

Diseases in the Transverse Myelitis family:

Acute Transverse Myelitis Secondary Acute Transverse Myelitis

Diseases related to Acute Transverse Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 274)
# Related Disease Score Top Affiliating Genes
1 myelitis 32.0 AQP4 IL6
2 lyme disease 30.5 IL6 MMP9
3 human immunodeficiency virus infectious disease 30.3 IL10 IL6
4 acute disseminated encephalomyelitis 30.2 AQP4 IL10
5 neuromyelitis optica 30.1 AQP4 IL6
6 osteomyelitis 29.9 CXCL8 IL10 IL6
7 chlamydia 29.9 CXCL8 IL10 IL6
8 pneumonia 29.9 CXCL8 IL10 IL6
9 multiple sclerosis 29.8 AQP4 IL10 IL6 MMP9
10 demyelinating disease 29.6 AQP4 IL10 MMP9
11 transverse myelitis 29.6 APOA1 AQP4 CXCL8 IL10 IL6 MMP2
12 arthritis 29.4 CXCL8 IL10 IL6 MMP9
13 idiopathic acute transverse myelitis 12.7
14 secondary acute transverse myelitis 12.5
15 coronary stenosis 10.3 APOA1 IL6
16 systemic lupus erythematosus 10.3
17 hepatitis 10.3
18 lupus erythematosus 10.3
19 tonsillitis 10.3 CXCL8 IL6
20 mastitis 10.3 CXCL8 IL6
21 pneumoconiosis 10.3 CXCL8 IL6
22 hemorrhagic fever with renal syndrome 10.3 CXCL8 IL6
23 obstructive jaundice 10.3 CXCL8 IL6
24 interstitial cystitis 10.3 CXCL8 IL6
25 bacterial vaginosis 10.3 CXCL8 IL6
26 avian influenza 10.3 CXCL8 IL6
27 placenta disease 10.3 CXCL8 IL6
28 bacterial pneumonia 10.3 CXCL8 IL6
29 encephalitis 10.3
30 recurrent corneal erosion 10.3 CXCL8 IL6
31 bagassosis 10.3 CXCL8 IL6
32 melioidosis 10.3 IL10 IL6
33 rheumatic heart disease 10.3 IL10 IL6
34 intervertebral disc disease 10.3 IL6 MMP9
35 autoimmune disease of musculoskeletal system 10.3 IL10 IL6
36 filariasis 10.3 IL10 IL6
37 paracoccidioidomycosis 10.3 IL10 IL6
38 parasitic protozoa infectious disease 10.3 IL10 IL6
39 uveal disease 10.3 IL10 IL6
40 mixed connective tissue disease 10.3 IL10 IL6
41 streptococcal toxic-shock syndrome 10.3 CXCL8 IL6
42 vaginitis 10.3 CXCL8 IL6
43 brain injury 10.3 IL10 IL6
44 denture stomatitis 10.3 CXCL8 IL6
45 papillary conjunctivitis 10.3 CXCL8 IL6
46 conjunctivitis 10.3 CXCL8 IL6
47 hemorrhagic fever 10.3 IL10 IL6
48 gallbladder disease 10.3 APOA1 IL10
49 ischemic heart disease 10.3 APOA1 IL6
50 acute monoblastic leukemia 10.2 CXCL8 IL6

Graphical network of the top 20 diseases related to Acute Transverse Myelitis:



Diseases related to Acute Transverse Myelitis

Symptoms & Phenotypes for Acute Transverse Myelitis

MGI Mouse Phenotypes related to Acute Transverse Myelitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 APOA1 AQP4 IL10 IL6 MMP2 MMP9
2 neoplasm MP:0002006 9.46 IL10 IL6 MMP2 MMP9
3 respiratory system MP:0005388 9.35 AQP4 IL10 IL6 MMP2 MMP9
4 vision/eye MP:0005391 9.02 AQP4 IL10 IL6 MMP2 MMP9

Drugs & Therapeutics for Acute Transverse Myelitis

Drugs for Acute Transverse Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
5
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
6 Prednisolone acetate Phase 3
7 Peripheral Nervous System Agents Phase 3
8 Anti-Inflammatory Agents Phase 3
9 Hormones Phase 3
10 Autonomic Agents Phase 3
11 Hormone Antagonists Phase 3
12 Antiemetics Phase 3
13 Methylprednisolone Acetate Phase 3
14 Neuroprotective Agents Phase 3
15 Gastrointestinal Agents Phase 3
16 glucocorticoids Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
18 Protective Agents Phase 3
19
rituximab Approved Phase 1 174722-31-7 10201696
20 Antirheumatic Agents Phase 1
21 Immunologic Factors Phase 1
22 Antibodies Phase 1
23 Antineoplastic Agents, Immunological Phase 1
24 Immunoglobulins Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Safety and Tolerability of Rituximab in Neuromyelitis Optica Completed NCT00501748 Phase 1 Rituximab

Search NIH Clinical Center for Acute Transverse Myelitis

Genetic Tests for Acute Transverse Myelitis

Anatomical Context for Acute Transverse Myelitis

MalaCards organs/tissues related to Acute Transverse Myelitis:

42
Spinal Cord, Brain, Thyroid, Skin, Kidney, Testes, Pancreas

Publications for Acute Transverse Myelitis

Articles related to Acute Transverse Myelitis:

(show top 50) (show all 220)
# Title Authors Year
1
Acute transverse myelitis - A rare clinical manifestation of Lyme neuroborreliosis. ( 30622896 )
2019
2
Clinical, laboratory features, and prognostic factors in adult acute transverse myelitis: an Italian multicenter study. ( 30903415 )
2019
3
Acute Transverse Myelitis in Children, Literature Review. ( 29696041 )
2018
4
Acute transverse myelitis following an opsoclonus-myoclonus syndrome: An unusual presentation. ( 29773357 )
2018
5
Acute Transverse Myelitis Caused by Echovirus 11 in a Pediatric Patient: Case Report and Review of the Current Literature. ( 29372173 )
2018
6
Clinical features and prognoses of acute transverse myelitis in patients with systemic lupus erythematosus. ( 29294596 )
2018
7
Familial monophasic acute transverse myelitis due to the pathogenic variant in <i>VPS37A</i>. ( 29473047 )
2018
8
Acute transverse myelitis following scrub typhus: A case report and review of the literature. ( 29350608 )
2018
9
Case Report: Acute Transverse Myelitis after Zika Virus Infection. ( 30277201 )
2018
10
Retained Glass Fragment in the Cervical Spinal Canal in a Patient with Acute Transverse Myelitis: A Case Report and Literature Review. ( 30009065 )
2018
11
Primary Epstein-Barr virus infection in immunocompetent patients with acute transverse myelitis and a combination of polyradiculitis and anterior horn syndrome as neurological manifestations. ( 30158264 )
2018
12
Acute transverse myelitis in a pediatric patient. ( 28215959 )
2017
13
Hepatitis B virus induced cytoplasmic antineutrophil cytoplasmic antibody-mediated vasculitis causing subarachnoid hemorrhage, acute transverse myelitis, and nephropathy: a case report. ( 28366165 )
2017
14
Thyroid hormone level is associated with the frequency and severity of acute transverse myelitis. ( 28240719 )
2017
15
Spinal Cord Infarction Mimicking Acute Transverse Myelitis. ( 29441246 )
2017
16
Urodynamic profile in acute transverse myelitis patients: Its correlation with neurological outcome. ( 28149080 )
2017
17
Remarks about &amp;quot;A pediatric patient of hemorrhagic acute transverse myelitis&amp;quot;. ( 28089121 )
2017
18
Pediatric acute transverse myelitis. ( 28678221 )
2017
19
A child with acute transverse myelitis requiring permanent pacemaker implantation. ( 28551037 )
2017
20
Reply to the remarks about &amp;quot;A pediatric patient of hemorrhagic acute transverse myelitis&amp;quot;. ( 28089122 )
2017
21
A rare case of acute transverse myelitis associated with Staphylococcusaureus bacteremia and osteomyelitis. ( 28584662 )
2017
22
Successfully Managed Acute Transverse Myelitis Related to Scrub Typhus and Serial Image Findings. ( 28115665 )
2017
23
Rehabilitation of a patient with overlap of acute transverse myelitis and Bickerstaff's brainstem encephalitis: a case report. ( 28053734 )
2016
24
Acute Transverse Myelitis and Nicolau Syndrome after Benzathine Penicillin Injection. ( 27762530 )
2016
25
An unusual case of acute transverse myelitis caused by HSV-1 infection. ( 27419072 )
2016
26
Acute Transverse Myelitis Associated with Salmonella Bacteremia: A Case Report. ( 27928148 )
2016
27
Concurrency of Guillain-Barre syndrome and acute transverse myelitis: a case report and review of literature. ( 28018472 )
2016
28
Acute transverse myelitis and subacute thyroiditis associated with dengue viral infection: A case report and literature review. ( 27703498 )
2016
29
Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction. ( 27645347 )
2016
30
Acute transverse myelitis in childhood: A single centre experience from North India. ( 26924166 )
2016
31
Cytokines and matrix metalloproteinases in the cerebrospinal fluid of patients with acute transverse myelitis: an outcome analysis. ( 26608499 )
2016
32
Acute transverse myelitis of the cervical spine secondary to psoas abscess. ( 27756229 )
2016
33
Elevated Lipid Profiles in Patients with Acute Transverse Myelitis. ( 26949935 )
2016
34
A pediatric patient of hemorrhagic acute transverse myelitis. ( 27686688 )
2016
35
Neurological and functional recovery in acute transverse myelitis patients with inpatient rehabilitation and magnetic resonance imaging correlates. ( 26927295 )
2016
36
Clinical insights for early detection of acute transverse myelitis in the emergency department. ( 27752572 )
2015
37
Idiopathic Acute Transverse Myelitis in Children: A Retrospective Series. ( 26267704 )
2015
38
Diagnostic transcranial magnetic stimulation as a prognostic tool in children with acute transverse myelitis. ( 26238314 )
2015
39
Concomitant acute transverse myelitis and sensory motor axonal polyneuropathy in two children: two case reports. ( 25750885 )
2015
40
Acute transverse myelitis arising after combined general and thoracic epidural anesthesia. ( 29497636 )
2015
41
Acute transverse myelitis during treatment with etanercept for severe plaque psoriasis. ( 24355280 )
2014
42
Lower motor neuron paralysis with extensive cord atrophy in parainfectious acute transverse myelitis. ( 25221410 )
2014
43
Systemic lupus erythematosus-associated acute transverse myelitis: manifestations, treatments, outcomes, and prognostic factors in 20 patients. ( 25117654 )
2014
44
Partial acute transverse myelitis is a predictor of multiple sclerosis in children. ( 24619933 )
2014
45
Acute transverse myelitis as the first clinical manifestation of systemic lupus erythematosus. ( 25591708 )
2014
46
Acute transverse myelitis and psoriasiform dermatitis associated with Sjoegren's syndrome: a case report. ( 25167870 )
2014
47
Acute transverse myelitis associated with human parvovirus b19 infection. ( 24049056 )
2014
48
Acute transverse myelitis complicating breakthrough varicella infection. ( 24853543 )
2014
49
Acute transverse myelitis: a rare neurological complication following wasp sting. ( 24608473 )
2014
50
The value of 3-T magnetic resonance imaging in acute transverse myelitis. ( 25444094 )
2014

Variations for Acute Transverse Myelitis

Expression for Acute Transverse Myelitis

Search GEO for disease gene expression data for Acute Transverse Myelitis.

Pathways for Acute Transverse Myelitis

Pathways related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 CXCL8 IL10 IL6 MMP2 MMP9
2 12.62 CXCL8 IL6 MMP2 MMP9
3
Show member pathways
12.38 IL10 IL6 MMP2
4
Show member pathways
12.15 CXCL8 IL6 MMP9
5 12.07 CXCL8 IL6 MMP9
6
Show member pathways
12.06 CXCL8 IL10 IL6
7 12 IL6 MMP2 MMP9
8 11.92 AQP4 CXCL8 IL10 IL6
9
Show member pathways
11.87 CXCL8 IL10 IL6
10
Show member pathways
11.87 IL6 MMP2 MMP9
11 11.76 CXCL8 IL6 MMP2
12 11.75 AQP4 CXCL8 IL6 MMP9
13 11.73 CXCL8 IL10 IL6
14 11.64 CXCL8 MMP2 MMP9
15 11.61 CXCL8 IL10 IL6
16 11.59 CXCL8 MMP2 MMP9
17 11.56 IL10 IL6 MMP9
18 11.49 CXCL8 MMP2 MMP9
19 11.44 CXCL8 IL6 MMP2 MMP9
20 11.43 CXCL8 IL6 MMP2
21 11.42 CXCL8 IL6
22 11.39 CXCL8 IL6
23 11.38 IL6 MMP2
24 11.36 CXCL8 IL10 IL6
25 11.36 CXCL8 IL6 MMP2 MMP9
26 11.34 CXCL8 IL6
27 11.34 CXCL8 IL10 IL6
28
Show member pathways
11.32 MMP2 MMP9
29 11.31 IL6 MMP2 MMP9
30
Show member pathways
11.26 CXCL8 IL6 MMP2 MMP9
31 11.2 IL10 IL6
32 11.18 APOA1 IL10 IL6
33 11.17 CXCL8 MMP2
34 11.16 MMP2 MMP9
35 11.11 IL10 IL6
36 11.08 CXCL8 IL10 IL6 MMP2 MMP9
37 11.06 MMP2 MMP9
38 11.03 CXCL8 IL10 IL6
39 10.99 MMP2 MMP9
40 10.9 CXCL8 IL6
41 10.79 CXCL8 IL6 MMP2 MMP9

GO Terms for Acute Transverse Myelitis

Cellular components related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 APOA1 CXCL8 IL10 IL6 MMP2 MMP9
2 collagen-containing extracellular matrix GO:0062023 9.33 APOA1 MMP2 MMP9
3 extracellular space GO:0005615 9.1 APOA1 CXCL8 IL10 IL6 MMP2 MMP9

Biological processes related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.61 APOA1 IL6 MMP2
2 cellular response to lipopolysaccharide GO:0071222 9.54 CXCL8 IL10 IL6
3 embryo implantation GO:0007566 9.49 MMP2 MMP9
4 collagen catabolic process GO:0030574 9.48 MMP2 MMP9
5 endodermal cell differentiation GO:0035987 9.46 MMP2 MMP9
6 leukocyte chemotaxis GO:0030595 9.4 CXCL8 IL10
7 response to molecule of bacterial origin GO:0002237 9.32 CXCL8 IL10
8 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.26 APOA1 IL10
9 negative regulation of cytokine secretion involved in immune response GO:0002740 9.16 APOA1 IL10
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.13 IL10 MMP2 MMP9
11 cytokine-mediated signaling pathway GO:0019221 9.02 CXCL8 IL10 IL6 MMP2 MMP9

Molecular functions related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL10 IL6

Sources for Acute Transverse Myelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....