MCID: ACT159
MIFTS: 44

Acute Transverse Myelitis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Transverse Myelitis

MalaCards integrated aliases for Acute Transverse Myelitis:

Name: Acute Transverse Myelitis 59
Myelitis, Acute Transverse 73

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA139417
UMLS via Orphanet 74 C0270627
ICD10 via Orphanet 34 G37.3
UMLS 73 C0270627

Summaries for Acute Transverse Myelitis

MalaCards based summary : Acute Transverse Myelitis, also known as myelitis, acute transverse, is related to myelitis and acute disseminated encephalomyelitis. An important gene associated with Acute Transverse Myelitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. The drugs Prednisolone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, thyroid and brain, and related phenotypes are cardiovascular system and neoplasm

Related Diseases for Acute Transverse Myelitis

Diseases in the Transverse Myelitis family:

Acute Transverse Myelitis Secondary Acute Transverse Myelitis

Diseases related to Acute Transverse Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
# Related Disease Score Top Affiliating Genes
1 myelitis 31.4 AQP4 IL6
2 acute disseminated encephalomyelitis 30.5 AQP4 IL10
3 neuromyelitis optica 29.8 AQP4 IL6
4 pneumonia 29.4 CXCL8 IL10 IL6
5 demyelinating disease 29.2 AQP4 IL10 MMP9
6 cytomegalovirus infection 29.1 CXCL8 IL10 IL6
7 chlamydia 29.0 CXCL8 IL10 IL6
8 multiple sclerosis 28.3 AQP4 IL10 IL6 MMP9
9 arthritis 28.0 CXCL8 IL10 IL6 MMP9
10 transverse myelitis 27.2 APOA1 AQP4 CXCL8 IL10 IL6 MMP2
11 idiopathic acute transverse myelitis 12.5
12 secondary acute transverse myelitis 12.4
13 tungiasis 10.5 CXCL8 IL10
14 pouchitis 10.5 CXCL8 IL10
15 scabies 10.5 CXCL8 IL10
16 neurosyphilis 10.5 CXCL8 IL10
17 necatoriasis 10.5 CXCL8 IL10
18 vulvovaginitis 10.5 CXCL8 IL10
19 trichuriasis 10.5 CXCL8 IL10
20 clonorchiasis 10.5 CXCL8 IL10
21 septic arthritis 10.4 CXCL8 MMP2
22 aseptic meningitis 10.4 CXCL8 IL10
23 primary peritoneal carcinoma 10.4 CXCL8 IL10
24 vibratory urticaria 10.4 CXCL8 MMP9
25 nasal cavity disease 10.4 CXCL8 IL10
26 cryptogenic organizing pneumonia 10.4 CXCL8 MMP9
27 nose disease 10.3 CXCL8 IL10
28 periodontosis 10.3 CXCL8 MMP9
29 tuberculous meningitis 10.3 CXCL8 MMP9
30 peptic ulcer disease 10.3 CXCL8 IL10
31 upper respiratory tract disease 10.3 CXCL8 IL10
32 shigellosis 10.3 CXCL8 IL10
33 extracranial arteriovenous malformation 10.2 MMP2 MMP9
34 focal myositis 10.2 MMP2 MMP9
35 spastic entropion 10.2 MMP2 MMP9
36 lentigo maligna melanoma 10.2 MMP2 MMP9
37 villous adenocarcinoma 10.2 MMP2 MMP9
38 psammomatous meningioma 10.2 MMP2 MMP9
39 senile ectropion 10.2 MMP2 MMP9
40 internal hemorrhoid 10.2 MMP2 MMP9
41 ischemic colitis 10.2 MMP2 MMP9
42 parotitis 10.2 MMP2 MMP9
43 light chain deposition disease 10.2 MMP2 MMP9
44 conjunctival nevus 10.2 MMP2 MMP9
45 klatskin's tumor 10.2 MMP2 MMP9
46 microcystic meningioma 10.2 MMP2 MMP9
47 adenomyosis 10.2 MMP2 MMP9
48 corneal ulcer 10.2 MMP2 MMP9
49 systemic lupus erythematosus 10.2
50 lupus erythematosus 10.2

Graphical network of the top 20 diseases related to Acute Transverse Myelitis:



Diseases related to Acute Transverse Myelitis

Symptoms & Phenotypes for Acute Transverse Myelitis

MGI Mouse Phenotypes related to Acute Transverse Myelitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 APOA1 AQP4 IL10 IL6 MMP2 MMP9
2 neoplasm MP:0002006 9.46 IL10 IL6 MMP2 MMP9
3 respiratory system MP:0005388 9.35 AQP4 IL10 IL6 MMP2 MMP9
4 vision/eye MP:0005391 9.02 IL10 IL6 MMP2 MMP9 AQP4

Drugs & Therapeutics for Acute Transverse Myelitis

Drugs for Acute Transverse Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
2
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
3 Prednisolone acetate Phase 3
4 glucocorticoids Phase 3
5 Methylprednisolone acetate Phase 3
6 Methylprednisolone Hemisuccinate Phase 3
7 Gastrointestinal Agents Phase 3
8 Neuroprotective Agents Phase 3
9 Hormone Antagonists Phase 3
10 Hormones Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Prednisolone hemisuccinate Phase 3
14 Prednisolone phosphate Phase 3
15 Antiemetics Phase 3
16 Protective Agents Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Autonomic Agents Phase 3
19
rituximab Approved Phase 1 174722-31-7 10201696
20 Antibodies Phase 1
21 Immunoglobulins Phase 1
22 Antirheumatic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Safety and Tolerability of Rituximab in Neuromyelitis Optica Completed NCT00501748 Phase 1 Rituximab

Search NIH Clinical Center for Acute Transverse Myelitis

Genetic Tests for Acute Transverse Myelitis

Anatomical Context for Acute Transverse Myelitis

MalaCards organs/tissues related to Acute Transverse Myelitis:

41
Spinal Cord, Thyroid, Brain, Testes, Skin, Pancreas, Kidney

Publications for Acute Transverse Myelitis

Articles related to Acute Transverse Myelitis:

(show top 50) (show all 204)
# Title Authors Year
1
Acute Transverse Myelitis in Children, Literature Review. ( 29696041 )
2018
2
Acute transverse myelitis following an opsoclonus-myoclonus syndrome: An unusual presentation. ( 29773357 )
2018
3
Acute Transverse Myelitis Caused by Echovirus 11 in a Pediatric Patient: Case Report and Review of the Current Literature. ( 29372173 )
2018
4
Clinical features and prognoses of acute transverse myelitis in patients with systemic lupus erythematosus. ( 29294596 )
2018
5
Familial monophasic acute transverse myelitis due to the pathogenic variant in <i>VPS37A</i>. ( 29473047 )
2018
6
Acute transverse myelitis following scrub typhus: A case report and review of the literature. ( 29350608 )
2018
7
Acute transverse myelitis in a pediatric patient. ( 28215959 )
2017
8
Hepatitis B virus induced cytoplasmic antineutrophil cytoplasmic antibody-mediated vasculitis causing subarachnoid hemorrhage, acute transverse myelitis, and nephropathy: a case report. ( 28366165 )
2017
9
Thyroid hormone level is associated with the frequency and severity of acute transverse myelitis. ( 28240719 )
2017
10
Spinal Cord Infarction Mimicking Acute Transverse Myelitis. ( 29441246 )
2017
11
Urodynamic profile in acute transverse myelitis patients: Its correlation with neurological outcome. ( 28149080 )
2017
12
Pediatric acute transverse myelitis. ( 28678221 )
2017
13
A child with acute transverse myelitis requiring permanent pacemaker implantation. ( 28551037 )
2017
14
A rare case of acute transverse myelitis associated with Staphylococcusaureus bacteremia and osteomyelitis. ( 28584662 )
2017
15
Successfully Managed Acute Transverse Myelitis Related to Scrub Typhus and Serial Image Findings. ( 28115665 )
2017
16
Rehabilitation of a patient with overlap of acute transverse myelitis and Bickerstaff's brainstem encephalitis: a case report. ( 28053734 )
2016
17
Acute Transverse Myelitis and Nicolau Syndrome after Benzathine Penicillin Injection. ( 27762530 )
2016
18
An unusual case of acute transverse myelitis caused by HSV-1 infection. ( 27419072 )
2016
19
Acute Transverse Myelitis Associated with Salmonella Bacteremia: A Case Report. ( 27928148 )
2016
20
Concurrency of Guillain-Barre syndrome and acute transverse myelitis: a case report and review of literature. ( 28018472 )
2016
21
Acute transverse myelitis and subacute thyroiditis associated with dengue viral infection: A case report and literature review. ( 27703498 )
2016
22
Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction. ( 27645347 )
2016
23
Acute transverse myelitis in childhood: A single centre experience from North India. ( 26924166 )
2016
24
Cytokines and matrix metalloproteinases in the cerebrospinal fluid of patients with acute transverse myelitis: an outcome analysis. ( 26608499 )
2016
25
Acute transverse myelitis of the cervical spine secondary to psoas abscess. ( 27756229 )
2016
26
Elevated Lipid Profiles in Patients with Acute Transverse Myelitis. ( 26949935 )
2016
27
A pediatric patient of hemorrhagic acute transverse myelitis. ( 27686688 )
2016
28
Neurological and functional recovery in acute transverse myelitis patients with inpatient rehabilitation and magnetic resonance imaging correlates. ( 26927295 )
2016
29
Clinical insights for early detection of acute transverse myelitis in the emergency department. ( 27752572 )
2015
30
Idiopathic Acute Transverse Myelitis in Children: A Retrospective Series. ( 26267704 )
2015
31
Diagnostic transcranial magnetic stimulation as a prognostic tool in children with acute transverse myelitis. ( 26238314 )
2015
32
Concomitant acute transverse myelitis and sensory motor axonal polyneuropathy in two children: two case reports. ( 25750885 )
2015
33
Acute transverse myelitis during treatment with etanercept for severe plaque psoriasis. ( 24355280 )
2014
34
Lower motor neuron paralysis with extensive cord atrophy in parainfectious acute transverse myelitis. ( 25221410 )
2014
35
Systemic lupus erythematosus-associated acute transverse myelitis: manifestations, treatments, outcomes, and prognostic factors in 20 patients. ( 25117654 )
2014
36
Partial acute transverse myelitis is a predictor of multiple sclerosis in children. ( 24619933 )
2014
37
Acute transverse myelitis as the first clinical manifestation of systemic lupus erythematosus. ( 25591708 )
2014
38
Acute transverse myelitis and psoriasiform dermatitis associated with Sjoegren's syndrome: a case report. ( 25167870 )
2014
39
Acute transverse myelitis associated with human parvovirus b19 infection. ( 24049056 )
2014
40
Acute transverse myelitis complicating breakthrough varicella infection. ( 24853543 )
2014
41
Acute transverse myelitis: a rare neurological complication following wasp sting. ( 24608473 )
2014
42
The value of 3-T magnetic resonance imaging in acute transverse myelitis. ( 25444094 )
2014
43
An acute transverse myelitis attack after total body irradiation: a rare case. ( 23984124 )
2013
44
Prognostic indicators of acute transverse myelitis in 39 children. ( 24112847 )
2013
45
Acute Transverse Myelitis Associated with Buserelin Use during IVF. ( 23607013 )
2013
46
Distinct serum apolipoprotein A-I levels in neuromyelitis optica and acute transverse myelitis. ( 24148653 )
2013
47
Acute transverse myelitis in a child with Lyme disease and a review of literature. ( 23498570 )
2013
48
Bacillus thuringiensis poisoning related acute transverse myelitis. ( 24340786 )
2013
49
Effective management of intractable neuropathic pain using an intrathecal morphine pump in a patient with acute transverse myelitis. ( 23935366 )
2013
50
Co-existence of acute transverse myelitis and Guillain-BarrAc syndrome associated with Bartonella henselae infection. ( 23930734 )
2013

Variations for Acute Transverse Myelitis

Expression for Acute Transverse Myelitis

Search GEO for disease gene expression data for Acute Transverse Myelitis.

Pathways for Acute Transverse Myelitis

Pathways related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 CXCL8 IL10 IL6 MMP2 MMP9
2 12.61 CXCL8 IL6 MMP2 MMP9
3
Show member pathways
12.42 CXCL8 IL10 IL6
4
Show member pathways
12.37 IL10 IL6 MMP2
5
Show member pathways
12.36 CXCL8 IL6 MMP9
6
Show member pathways
12.13 CXCL8 IL6 MMP9
7 12.06 CXCL8 IL6 MMP9
8 11.99 IL6 MMP2 MMP9
9 11.92 AQP4 CXCL8 IL10 IL6
10 11.75 CXCL8 IL6 MMP2
11 11.75 AQP4 CXCL8 IL6 MMP9
12 11.73 CXCL8 IL10 IL6
13 11.63 CXCL8 MMP2 MMP9
14 11.6 CXCL8 IL10 IL6
15 11.58 CXCL8 MMP2 MMP9
16 11.49 CXCL8 MMP2 MMP9
17 11.44 CXCL8 IL6 MMP2 MMP9
18 11.43 CXCL8 IL6 MMP2
19 11.42 CXCL8 IL6
20 11.38 CXCL8 IL6
21 11.38 IL6 MMP2
22 11.36 CXCL8 IL10 IL6
23 11.36 CXCL8 IL6 MMP2 MMP9
24 11.34 CXCL8 IL10 IL6
25 11.33 CXCL8 IL6
26
Show member pathways
11.31 MMP2 MMP9
27 11.31 IL6 MMP2 MMP9
28
Show member pathways
11.26 CXCL8 IL6 MMP2 MMP9
29 11.19 IL10 IL6
30 11.16 CXCL8 MMP2
31 11.15 APOA1 IL10 IL6
32 11.14 MMP2 MMP9
33 11.11 IL10 IL6
34 11.08 CXCL8 IL10 IL6 MMP2 MMP9
35 11.04 MMP2 MMP9
36 10.98 MMP2 MMP9
37 10.88 CXCL8 IL6
38 10.79 CXCL8 IL6 MMP2 MMP9

GO Terms for Acute Transverse Myelitis

Cellular components related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 APOA1 CXCL8 IL10 IL6 MMP2 MMP9
2 extracellular matrix GO:0031012 9.33 APOA1 MMP2 MMP9
3 extracellular space GO:0005615 9.1 APOA1 CXCL8 IL10 IL6 MMP2 MMP9

Biological processes related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.61 APOA1 IL6 MMP2
2 cellular response to lipopolysaccharide GO:0071222 9.54 CXCL8 IL10 IL6
3 embryo implantation GO:0007566 9.48 MMP2 MMP9
4 endodermal cell differentiation GO:0035987 9.46 MMP2 MMP9
5 positive regulation of leukocyte chemotaxis GO:0002690 9.4 CXCL8 IL6
6 response to molecule of bacterial origin GO:0002237 9.32 CXCL8 IL10
7 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.26 APOA1 IL10
8 negative regulation of cytokine secretion involved in immune response GO:0002740 9.16 APOA1 IL10
9 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.13 IL10 MMP2 MMP9
10 cytokine-mediated signaling pathway GO:0019221 9.02 CXCL8 IL10 IL6 MMP2 MMP9

Molecular functions related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL10 IL6

Sources for Acute Transverse Myelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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