MCID: ACT159
MIFTS: 38

Acute Transverse Myelitis

Categories: Immune diseases, Infectious diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Transverse Myelitis

MalaCards integrated aliases for Acute Transverse Myelitis:

Name: Acute Transverse Myelitis 58
Myelitis, Acute Transverse 71

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 G37.3
UMLS via Orphanet 72 C0270627
Orphanet 58 ORPHA139417
UMLS 71 C0270627

Summaries for Acute Transverse Myelitis

MalaCards based summary : Acute Transverse Myelitis, also known as myelitis, acute transverse, is related to myelitis and acute disseminated encephalomyelitis. An important gene associated with Acute Transverse Myelitis is APOA1 (Apolipoprotein A1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Prednisolone acetate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and pancreas, and related phenotypes are cardiovascular system and respiratory system

Related Diseases for Acute Transverse Myelitis

Diseases in the Transverse Myelitis family:

Acute Transverse Myelitis

Diseases related to Acute Transverse Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 504)
# Related Disease Score Top Affiliating Genes
1 myelitis 30.8 MMP9 IL6 IL10 CXCL8 AQP4
2 acute disseminated encephalomyelitis 30.7 IL10 AQP4
3 chickenpox 30.6 IL6 IL10
4 encephalitis 30.3 IL6 IL10 AQP4
5 severe acute respiratory syndrome 30.1 IL6 IL10 CXCL8
6 systemic autoimmune disease 30.1 MMP9 IL6
7 iritis 30.0 IL6 IL10
8 respiratory failure 30.0 IL6 IL10 CXCL8
9 aseptic meningitis 30.0 IL10 CXCL8
10 spinal cord disease 30.0 IL6 IL10 AQP4
11 pneumonia 29.9 IL6 IL10 CXCL8
12 mumps 29.9 IL6 IL10 CXCL8
13 demyelinating disease 29.9 MMP9 IL6 IL10 AQP4
14 transverse myelitis 29.8 MMP9 MMP2 IL6 IL10 CXCL8 AQP4
15 chlamydia 29.7 IL6 IL10 CXCL8
16 bronchopneumonia 29.7 IL6 IL10 CXCL8
17 viral encephalitis 29.7 IL6 IL10 CXCL8
18 cerebrovascular disease 29.7 MMP9 IL6 APOA1
19 bacterial infectious disease 29.7 IL6 IL10 CXCL8
20 osteomyelitis 29.7 IL6 IL10 CXCL8
21 uveitis 29.7 IL6 IL10 CXCL8
22 dermatitis 29.7 IL6 IL10 CXCL8
23 synovitis 29.7 MMP9 IL6 CXCL8
24 pertussis 29.7 IL6 IL10 CXCL8
25 autoimmune disease 29.7 MMP9 IL6 IL10 CXCL8
26 diarrhea 29.6 IL6 IL10 CXCL8
27 spinal cord injury 29.4 MMP9 IL6 CXCL8 AQP4
28 systemic lupus erythematosus 29.3 MMP9 MMP2 IL6 IL10 CXCL8
29 multiple sclerosis 29.0 MMP9 IL6 IL10 CXCL8 AQP4 APOA1
30 peripheral nervous system disease 29.0 MMP9 IL6 IL10 CXCL8 AQP4
31 nervous system disease 29.0 MMP9 IL6 IL10 CXCL8 AQP4
32 acute transverse myelitis with anti-mog antibodies 11.5
33 idiopathic acute transverse myelitis 11.4
34 paraplegia 10.6
35 neuromyelitis optica 10.6
36 guillain-barre syndrome 10.6
37 quadriplegia 10.5
38 autonomic dysfunction 10.5
39 lupus erythematosus 10.4
40 polyneuropathy 10.4
41 axonal neuropathy 10.4
42 lyme disease 10.3
43 candidiasis, familial, 1 10.3
44 constipation 10.3
45 paresthesia 10.3
46 epidemic typhus 10.2
47 japanese encephalitis 10.2
48 neurogenic bladder 10.2
49 detrusor sphincter dyssynergia 10.2
50 hepatitis a 10.2

Graphical network of the top 20 diseases related to Acute Transverse Myelitis:



Diseases related to Acute Transverse Myelitis

Symptoms & Phenotypes for Acute Transverse Myelitis

MGI Mouse Phenotypes related to Acute Transverse Myelitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 APOA1 AQP4 IL10 IL6 MMP2 MMP9
2 respiratory system MP:0005388 9.02 AQP4 IL10 IL6 MMP2 MMP9

Drugs & Therapeutics for Acute Transverse Myelitis

Drugs for Acute Transverse Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
2
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
3
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
7 Methylprednisolone Acetate Phase 3
8
rituximab Approved Phase 1 174722-31-7 10201696
9 Immunologic Factors Phase 1
10 Antineoplastic Agents, Immunological Phase 1
11 Immunoglobulins Phase 1
12 Antirheumatic Agents Phase 1
13 Antibodies Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Open Label Study of Safety and Tolerability of Rituximab in Neuromyelitis Optica, Recurrent Transverse Myelitis and Recurrent Bilateral Simultaneous Optic Neuritis Completed NCT00501748 Phase 1 Rituximab

Search NIH Clinical Center for Acute Transverse Myelitis

Genetic Tests for Acute Transverse Myelitis

Anatomical Context for Acute Transverse Myelitis

MalaCards organs/tissues related to Acute Transverse Myelitis:

40
Spinal Cord, Bone Marrow, Pancreas

Publications for Acute Transverse Myelitis

Articles related to Acute Transverse Myelitis:

(show top 50) (show all 492)
# Title Authors PMID Year
1
Neurological manifestations of coronavirus disease 2019: exploring past to understand present. 61
33428055 2021
2
Acupuncture treatment in pediatric acute transverse myelitis: a case report. 61
33567857 2021
3
Prognostic factors for relapse and outcome in pediatric acute transverse myelitis. 61
33509615 2021
4
Acute transverse myelitis of childhood due to novel coronavirus disease 2019: The first pediatric case report and review of literature. 61
33558819 2021
5
Neuromyelitis optica spectrum disorder (NMOSD) presenting as acute transverse myelitis with positive aquaporin 4 antibodies. 61
33504530 2021
6
Neurological manifestations associated with SARS-CoV-2 and other coronaviruses: A narrative review for clinicians. 61
33446327 2021
7
Epidemiological findings of neuromyelitis optica spectrum disorders in a Venezuelan study. 61
33279797 2021
8
Neuromyelitis Optica Presenting as Infectious Meningoencephalitis: Case Report and Literature Review. 61
33342552 2020
9
Pediatric Inflammatory and Autoimmune Neurologic Disorders at a Tertiary Medical Center. 61
32677585 2020
10
COVID-19 infection and stroke risk. 61
33580645 2020
11
Prognostic Parameters of Acute Transverse Myelitis in Children. 61
32808576 2020
12
Respiratory failure secondary to cytomegalovirus-associated acute transverse myelitis in an immunocompetent adult. 61
32659334 2020
13
Clinical efficacy of γ-globulin combined with dexamethasone and methylprednisolone, respectively, in the treatment of acute transverse myelitis and its effects on immune function and quality of life. 61
32989383 2020
14
Environmental Issues and Neurological Manifestations Associated with COVID-19 Pandemic: New Aspects of the Disease? 61
33139595 2020
15
Frequency and etiology of acute transverse myelitis in Southern Finland. 61
33059215 2020
16
Differential diagnosis in acute inflammatory myelitis. 61
32905999 2020
17
Acute myelitis and SARS-CoV-2 infection. A new etiology of myelitis? 61
33099361 2020
18
The Neurological Complexities and Prognosis of COVID-19. 61
33015552 2020
19
Clinical and radiological profile of neuromyelitis optica spectrum disorders in an Ecuadorian cohort. 61
32562910 2020
20
Acute transverse myelitis in COVID-19 infection. 61
32784242 2020
21
COVID-19-associated acute transverse myelitis: a rare entity. 61
32843475 2020
22
Acute transverse myelitis after COVID-19 pneumonia. 61
32458198 2020
23
Acute Transverse Myelitis Secondary to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Case Report. 61
32926682 2020
24
A Case Report of Acute Transverse Myelitis Following Novel Coronavirus Infection. 61
32926676 2020
25
Synchronous Occurrence of Guillain-Barre Syndrome and Transverse Myelitis of Unknown Etiology in an Adolescent. 61
32923245 2020
26
A comparative study on clinical characterizations between acute myelitis onset of neuromyelitis optica spectrum disease and idiopathic transverse myelitis. 61
32497470 2020
27
Acute Transverse Myelitis and Acute Disseminated Encephalomyelitis. 61
32611797 2020
28
Neurological manifestations and complications of COVID-19: A literature review. 61
32409215 2020
29
Myelopathy in West Nile virus encephalitis: Report of a case and review of literature. 61
30124385 2020
30
Acute transverse myelitis following scrub typhus: A case report and review of the literature. 61
29350608 2020
31
AQP4-IgG may cause muscle damage in patients with neuromyelitis optica spectrum disorder. 61
32413837 2020
32
Tuberculous Myelopathy Associated with Longitudinally Extensive Lesion: A Clinicoradiological Review of Reported Cases. 61
32657056 2020
33
Acute infectious myelopathies. 61
32332224 2020
34
Neurological Adverse Effects Associated With Anti-tumor Necrosis Factor Alpha Antibodies in Pediatric Inflammatory Bowel Diseases. 61
32443044 2020
35
Secondary Scoliosis as a Complication of Acute Transverse Myelitis in a Child. 61
33467256 2020
36
Acute transverse myelitis associated with SARS-CoV-2: A Case-Report. 61
32835294 2020
37
Case of neuromyelitis optica: bilateral sensorineural hearing loss and transverse myelopathy following intrathecal chemotherapy. 61
32300035 2020
38
Concomitant Guillain-Barré Syndrome and Acute Transverse Myelitis in an Older Adult-A Case Report. 61
32285429 2020
39
Transverse Myelitis in Systemic Lupus Erythematosus: Clinical Features and Prognostic Factors in a Large Cohort of Latin American Patients. 61
32028309 2020
40
The Emergent Evaluation and Treatment of Neck and Back Pain. 61
31757249 2020
41
Guillain-Barré and Acute Transverse Myelitis Overlap Syndrome Following Obstetric Surgery. 61
32104735 2020
42
Acute Transverse and Flaccid Myelitis in Children. 61
31792626 2019
43
Aquaporin-4-IgG positive neuromyelitis optica spectrum disorder and systemic autoimmune diseases overlap syndrome: a single-center experience. 61
31566079 2019
44
Infectious myelitis. 61
31375285 2019
45
Acute flaccid myelitis and enterovirus D68: lessons from the past and present. 61
31338675 2019
46
A Rare Case of Acute Transverse Myelitis (ATM) and Acute Motor and Sensory Axonal Neuropathy (AMSAN) Overlap. 61
31632877 2019
47
MRI Predictors of Recurrence and Outcome after Acute Transverse Myelitis of Unidentified Etiology. 61
31296526 2019
48
Mycoplasma pneumoniaeassociated transverse myelitis presenting as asymmetric flaccid paralysis. 61
31579494 2019
49
Clinical, laboratory features, and prognostic factors in adult acute transverse myelitis: an Italian multicenter study. 61
30903415 2019
50
Neuro-Chikungunya: Acute Transverse Myelopathy Associated with Chikungunya Virus Infection. 61
31559781 2019

Variations for Acute Transverse Myelitis

Expression for Acute Transverse Myelitis

Search GEO for disease gene expression data for Acute Transverse Myelitis.

Pathways for Acute Transverse Myelitis

Pathways related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 MMP9 MMP2 IL6 IL10 CXCL8
2
Show member pathways
12.83 MMP9 IL6 IL10 CXCL8
3 12.62 MMP9 MMP2 IL6 CXCL8
4
Show member pathways
12.14 MMP9 IL6 CXCL8
5
Show member pathways
12.14 IL6 IL10 CXCL8
6 12.08 MMP9 IL6 CXCL8
7 12 MMP9 MMP2 IL6
8 11.91 IL6 IL10 CXCL8 AQP4
9 11.9 IL6 IL10 CXCL8
10 11.76 IL6 IL10 CXCL8
11 11.75 MMP9 IL6 CXCL8 AQP4
12 11.74 MMP2 IL6 CXCL8
13 11.63 MMP9 MMP2 CXCL8
14 11.6 IL6 IL10 CXCL8
15 11.58 MMP9 MMP2 CXCL8
16 11.49 MMP9 MMP2 CXCL8
17 11.44 MMP9 MMP2 IL6 CXCL8
18 11.43 MMP2 IL6 CXCL8
19 11.37 IL6 IL10 CXCL8
20
Show member pathways
11.36 MMP9 MMP2 IL6 CXCL8
21 11.34 IL6 IL10 CXCL8
22
Show member pathways
11.32 MMP9 MMP2
23 11.31 MMP9 MMP2 IL6
24 11.26 MMP9 MMP2 IL6 CXCL8
25 11.2 IL6 IL10
26 11.18 IL6 IL10 APOA1
27 11.17 MMP2 CXCL8
28 11.16 MMP9 MMP2
29 11.11 IL6 IL10
30 11.08 MMP9 MMP2 IL6 IL10 CXCL8
31 11.05 MMP9 MMP2
32 10.98 MMP9 MMP2
33 10.89 IL6 CXCL8
34 10.79 MMP9 MMP2 IL6 CXCL8

GO Terms for Acute Transverse Myelitis

Cellular components related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 MMP9 MMP2 IL6 IL10 CXCL8 APOA1
2 extracellular region GO:0005576 9.17 MMP9 MMP2 IL6 IL10 CXCL8 AQP4

Biological processes related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.69 MMP2 IL6 APOA1
2 cellular response to lipopolysaccharide GO:0071222 9.65 IL6 IL10 CXCL8
3 collagen catabolic process GO:0030574 9.58 MMP9 MMP2
4 cellular response to reactive oxygen species GO:0034614 9.57 MMP9 MMP2
5 embryo implantation GO:0007566 9.56 MMP9 MMP2
6 liver regeneration GO:0097421 9.55 IL6 IL10
7 positive regulation of JAK-STAT cascade GO:0046427 9.54 IL6 IL10
8 endodermal cell differentiation GO:0035987 9.52 MMP9 MMP2
9 positive regulation of immunoglobulin production GO:0002639 9.49 IL6 IL10
10 negative regulation of cell adhesion molecule production GO:0060354 9.46 CXCL8 APOA1
11 response to amyloid-beta GO:1904645 9.43 MMP9 MMP2
12 regulation of neuroinflammatory response GO:0150077 9.4 MMP9 IL6
13 cellular response to UV-A GO:0071492 9.37 MMP9 MMP2
14 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.32 IL10 APOA1
15 response to molecule of bacterial origin GO:0002237 9.26 IL10 CXCL8
16 negative regulation of cytokine production involved in immune response GO:0002719 9.16 IL10 APOA1
17 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.13 MMP9 MMP2 IL10
18 cytokine-mediated signaling pathway GO:0019221 9.02 MMP9 MMP2 IL6 IL10 CXCL8

Molecular functions related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL6 IL10 CXCL8

Sources for Acute Transverse Myelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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