MCID: ACT159
MIFTS: 38

Acute Transverse Myelitis

Categories: Immune diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Transverse Myelitis

MalaCards integrated aliases for Acute Transverse Myelitis:

Name: Acute Transverse Myelitis 58
Myelitis, Acute Transverse 71

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 G37.3
UMLS via Orphanet 72 C0270627
Orphanet 58 ORPHA139417
UMLS 71 C0270627

Summaries for Acute Transverse Myelitis

MalaCards based summary : Acute Transverse Myelitis, also known as myelitis, acute transverse, is related to acute disseminated encephalomyelitis and chickenpox. An important gene associated with Acute Transverse Myelitis is APOA1 (Apolipoprotein A1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and bone, and related phenotypes are cardiovascular system and respiratory system

Related Diseases for Acute Transverse Myelitis

Diseases in the Transverse Myelitis family:

Acute Transverse Myelitis Secondary Acute Transverse Myelitis

Diseases related to Acute Transverse Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 467)
# Related Disease Score Top Affiliating Genes
1 acute disseminated encephalomyelitis 30.6 IL10 AQP4
2 chickenpox 30.5 IL6 IL10
3 myelitis 30.3 MMP9 IL6 IL10 CXCL8 AQP4
4 encephalitis 30.1 IL6 IL10 AQP4
5 systemic autoimmune disease 30.0 MMP9 IL6
6 spinal cord disease 29.8 IL6 IL10 AQP4
7 mumps 29.7 IL6 IL10 CXCL8
8 respiratory failure 29.6 IL6 IL10 CXCL8
9 acquired immunodeficiency syndrome 29.6 IL6 IL10 APOA1
10 chlamydia 29.5 IL6 IL10 CXCL8
11 bronchopneumonia 29.5 IL6 IL10 CXCL8
12 viral encephalitis 29.5 IL6 IL10 CXCL8
13 demyelinating disease 29.5 MMP9 IL6 IL10 AQP4
14 dermatitis 29.5 IL6 IL10 CXCL8
15 osteomyelitis 29.5 IL6 IL10 CXCL8
16 uveitis 29.5 IL6 IL10 CXCL8
17 synovitis 29.5 MMP9 IL6 CXCL8
18 pertussis 29.5 IL6 IL10 CXCL8
19 diarrhea 29.3 IL6 IL10 CXCL8
20 pneumonia 29.2 MMP9 IL6 IL10 CXCL8
21 spinal cord injury 29.1 MMP9 IL6 CXCL8 AQP4
22 peripheral nervous system disease 29.1 IL6 IL10 CXCL8 AQP4
23 transverse myelitis 29.0 MMP9 MMP2 IL6 IL10 CXCL8 AQP4
24 arthritis 29.0 MMP9 IL6 IL10 CXCL8
25 autoimmune disease 28.9 MMP9 IL6 IL10 CXCL8 AQP4
26 systemic lupus erythematosus 28.8 MMP9 MMP2 IL6 IL10 CXCL8
27 multiple sclerosis 28.4 MMP9 IL6 IL10 CXCL8 AQP4 APOA1
28 idiopathic acute transverse myelitis 12.8
29 secondary acute transverse myelitis 12.7
30 paraplegia 10.6
31 neuromyelitis optica 10.5
32 guillain-barre syndrome 10.5
33 lupus erythematosus 10.5
34 quadriplegia 10.5
35 autonomic dysfunction 10.5
36 polyneuropathy 10.4
37 axonal neuropathy 10.3
38 lyme disease 10.3
39 candidiasis, familial, 1 10.3
40 epidemic typhus 10.2
41 japanese encephalitis 10.2
42 neurogenic bladder 10.2
43 detrusor sphincter dyssynergia 10.2
44 hepatitis a 10.2
45 scrub typhus 10.2
46 constipation 10.2
47 antiphospholipid syndrome 10.2
48 vasculitis 10.2
49 rubella 10.2
50 paresthesia 10.2

Graphical network of the top 20 diseases related to Acute Transverse Myelitis:



Diseases related to Acute Transverse Myelitis

Symptoms & Phenotypes for Acute Transverse Myelitis

MGI Mouse Phenotypes related to Acute Transverse Myelitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 APOA1 AQP4 IL10 IL6 MMP2 MMP9
2 respiratory system MP:0005388 9.02 AQP4 IL10 IL6 MMP2 MMP9

Drugs & Therapeutics for Acute Transverse Myelitis

Drugs for Acute Transverse Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
4 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
7 Methylprednisolone Acetate Phase 3
8
rituximab Approved Phase 1 174722-31-7 10201696
9 Immunoglobulins Phase 1
10 Antibodies Phase 1
11 Immunologic Factors Phase 1
12 Antirheumatic Agents Phase 1
13 Antineoplastic Agents, Immunological Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Randomized Clinical Trial of Plasma Exchanges Versus Sham Plasma Exchanges in Disabling Multiple Sclerosis Acute Relapses Refractory to Steroid Treatment Completed NCT01442233 Phase 3
3 Open Label Study of Safety and Tolerability of Rituximab in Neuromyelitis Optica, Recurrent Transverse Myelitis and Recurrent Bilateral Simultaneous Optic Neuritis Completed NCT00501748 Phase 1 Rituximab

Search NIH Clinical Center for Acute Transverse Myelitis

Genetic Tests for Acute Transverse Myelitis

Anatomical Context for Acute Transverse Myelitis

MalaCards organs/tissues related to Acute Transverse Myelitis:

40
Spinal Cord, Bone Marrow, Bone, Brain, Thyroid, Skin, Kidney

Publications for Acute Transverse Myelitis

Articles related to Acute Transverse Myelitis:

(show top 50) (show all 467)
# Title Authors PMID Year
1
Neurological manifestations and complications of COVID-19: A literature review. 61
32409215 2020
2
A comparative study on clinical characterizations between acute myelitis onset of neuromyelitis optica spectrum disease and idiopathic transverse myelitis. 61
32497470 2020
3
AQP4-IgG may cause muscle damage in patients with neuromyelitis optica spectrum disorder. 61
32413837 2020
4
Acute infectious myelopathies. 61
32332224 2020
5
Neurological Adverse Effects Associated With Anti-tumor Necrosis Factor Alpha Antibodies in Pediatric Inflammatory Bowel Diseases. 61
32443044 2020
6
Acute transverse myelitis after COVID-19 pneumonia. 61
32458198 2020
7
Clinical and radiological profile of neuromyelitis optica spectrum disorders in an Ecuadorian cohort. 61
32562910 2020
8
Case of neuromyelitis optica: bilateral sensorineural hearing loss and transverse myelopathy following intrathecal chemotherapy. 61
32300035 2020
9
Concomitant Guillain-Barré Syndrome and Acute Transverse Myelitis in an Older Adult-A Case Report. 61
32285429 2020
10
Neurological Adverse Effects Associated with anti-TNF Alpha Antibodies in Pediatric Inflammatory Bowel Diseases. 61
32044838 2020
11
The Emergent Evaluation and Treatment of Neck and Back Pain. 61
31757249 2020
12
Transverse Myelitis in Systemic Lupus Erythematosus: Clinical Features and Prognostic Factors in a Large Cohort of Latin American Patients. 61
32028309 2020
13
Guillain-Barré and Acute Transverse Myelitis Overlap Syndrome Following Obstetric Surgery. 61
32104735 2020
14
Acute Transverse and Flaccid Myelitis in Children. 61
31792626 2019
15
Aquaporin-4-IgG positive neuromyelitis optica spectrum disorder and systemic autoimmune diseases overlap syndrome: a single-center experience. 61
31566079 2019
16
Infectious myelitis. 61
31375285 2019
17
Acute flaccid myelitis and enterovirus D68: lessons from the past and present. 61
31338675 2019
18
A Rare Case of Acute Transverse Myelitis (ATM) and Acute Motor and Sensory Axonal Neuropathy (AMSAN) Overlap. 61
31632877 2019
19
Mycoplasma pneumoniaeassociated transverse myelitis presenting as asymmetric flaccid paralysis. 61
31579494 2019
20
MRI Predictors of Recurrence and Outcome after Acute Transverse Myelitis of Unidentified Etiology. 61
31296526 2019
21
Clinical, laboratory features, and prognostic factors in adult acute transverse myelitis: an Italian multicenter study. 61
30903415 2019
22
Successful intravenous immunoglobulin treatment in relapsing MOG-antibody-associated disease. 61
31026608 2019
23
Neuro-Chikungunya: Acute Transverse Myelopathy Associated with Chikungunya Virus Infection. 61
31559781 2019
24
An acute transverse myelitis attack after autologous stem cell transplantation: A rare case. 61
31113744 2019
25
Clinical features and prognosis of patients with Guillain-Barré and acute transverse myelitis overlap syndrome. 61
31039494 2019
26
A pilot safety study of ublituximab, a monoclonal antibody against CD20, in acute relapses of neuromyelitis optica spectrum disorder. 61
31232925 2019
27
Neuromyelitis Optica Spectrum Disorder and Anti-MOG Syndromes. 61
31212763 2019
28
Clinical Approach to Pediatric Transverse Myelitis, Neuromyelitis Optica Spectrum Disorder and Acute Flaccid Myelitis. 61
31109018 2019
29
Lyme myelopathy: Case report and literature review of a rare but treatable disorder. 61
30654245 2019
30
Aetiology of Myelopathy in a Tertiary Hospital of Bangladesh. 61
31086136 2019
31
Clinical features and prognoses of acute transverse myelitis in patients with systemic lupus erythematosus. 61
29294596 2019
32
Transverse Myelitis and Guillain-Barré Syndrome Overlap Secondary to Bartonella henselae: Case Report. 61
31935348 2019
33
Coexistence of Neuromyelitis Optica and Amyotrophic Lateral Sclerosis: A Case Report. 61
30671163 2019
34
Acute transverse myelitis - A rare clinical manifestation of Lyme neuroborreliosis. 61
30622896 2019
35
A rare neurological complication of tuberculosis: Transverse myelitis. 61
31193733 2019
36
Intrathecal formation of anticardiolipin antibodies in a patient with SLE-related relapsing longitudinal myelitis: a possible pathogenic connection. 61
30394833 2018
37
Case Report: Acute Transverse Myelitis after Zika Virus Infection. 61
30277201 2018
38
Primary Bone Marrow Diffuse Large B-cell Lymphoma Presenting as Transverse Myelitis. 61
30447708 2018
39
Detection of aquaporin-4 antibodies for patients with CNS inflammatory demyelinating diseases other than typical MS in Lithuania. 61
30284401 2018
40
Flaccid paralysis in neuromyelitis optica: An atypical presentation with possible involvement of the peripheral nervous system. 61
30056360 2018
41
Acute transverse myelitis following an opsoclonus-myoclonus syndrome: An unusual presentation. 61
29773357 2018
42
Myelopathy in West Nile virus encephalitis: Report of a case and review of literature. 61
30124385 2018
43
Primary Epstein-Barr virus infection in immunocompetent patients with acute transverse myelitis and a combination of polyradiculitis and anterior horn syndrome as neurological manifestations. 61
30158264 2018
44
Post Varicella Zoster Acute Transverse Myelitis. 61
31324103 2018
45
Natural history of longitudinally extensive transverse myelitis in 35 Hispanic patients with systemic lupus erythematosus: good short-term functional outcome and paradoxical increase in long-term mortality. 61
29635997 2018
46
Plasma Exchange for Neuromyelitis Optica Spectrum Disorders in Chinese Patients and Factors Predictive of Short-term Outcome. 61
29606515 2018
47
Longitudinally Extensive Transverse Myelitis Due to Toxoplasma: An Autopsy Study. 61
30122845 2018
48
A case report of neuromyelitis optica spectrum disorder with peripheral neuropathy as the first episode. 61
29517664 2018
49
Familial monophasic acute transverse myelitis due to the pathogenic variant in VPS37A. 61
29473047 2018
50
Retained Glass Fragment in the Cervical Spinal Canal in a Patient with Acute Transverse Myelitis: A Case Report and Literature Review. 61
30009065 2018

Variations for Acute Transverse Myelitis

Expression for Acute Transverse Myelitis

Search GEO for disease gene expression data for Acute Transverse Myelitis.

Pathways for Acute Transverse Myelitis

Pathways related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 MMP9 MMP2 IL6 IL10 CXCL8
2
Show member pathways
12.83 MMP9 IL6 IL10 CXCL8
3 12.62 MMP9 MMP2 IL6 CXCL8
4
Show member pathways
12.14 MMP9 IL6 CXCL8
5
Show member pathways
12.14 IL6 IL10 CXCL8
6 12.08 MMP9 IL6 CXCL8
7 12 MMP9 MMP2 IL6
8 11.91 IL6 IL10 CXCL8 AQP4
9 11.84 IL6 IL10 CXCL8
10 11.76 IL6 IL10 CXCL8
11 11.75 MMP9 IL6 CXCL8 AQP4
12 11.74 MMP2 IL6 CXCL8
13 11.63 MMP9 MMP2 CXCL8
14 11.6 IL6 IL10 CXCL8
15 11.58 MMP9 MMP2 CXCL8
16 11.49 MMP9 MMP2 CXCL8
17 11.44 MMP9 MMP2 IL6 CXCL8
18 11.43 MMP2 IL6 CXCL8
19 11.37 IL6 IL10 CXCL8
20
Show member pathways
11.36 MMP9 MMP2 IL6 CXCL8
21 11.34 IL6 IL10 CXCL8
22
Show member pathways
11.32 MMP9 MMP2
23 11.31 MMP9 MMP2 IL6
24 11.26 MMP9 MMP2 IL6 CXCL8
25 11.2 IL6 IL10
26 11.18 IL6 IL10 APOA1
27 11.17 MMP2 CXCL8
28 11.16 MMP9 MMP2
29 11.11 IL6 IL10
30 11.08 MMP9 MMP2 IL6 IL10 CXCL8
31 11.05 MMP9 MMP2
32 10.98 MMP9 MMP2
33 10.89 IL6 CXCL8
34 10.79 MMP9 MMP2 IL6 CXCL8

GO Terms for Acute Transverse Myelitis

Cellular components related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 MMP9 MMP2 IL6 IL10 CXCL8 APOA1
2 extracellular region GO:0005576 9.17 MMP9 MMP2 IL6 IL10 CXCL8 AQP4

Biological processes related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.67 MMP2 IL6 APOA1
2 cellular response to lipopolysaccharide GO:0071222 9.63 IL6 IL10 CXCL8
3 embryo implantation GO:0007566 9.56 MMP9 MMP2
4 collagen catabolic process GO:0030574 9.55 MMP9 MMP2
5 cellular response to reactive oxygen species GO:0034614 9.54 MMP9 MMP2
6 positive regulation of JAK-STAT cascade GO:0046427 9.52 IL6 IL10
7 endodermal cell differentiation GO:0035987 9.51 MMP9 MMP2
8 leukocyte chemotaxis GO:0030595 9.48 IL10 CXCL8
9 response to amyloid-beta GO:1904645 9.43 MMP9 MMP2
10 regulation of neuroinflammatory response GO:0150077 9.4 MMP9 IL6
11 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.37 IL10 APOA1
12 response to molecule of bacterial origin GO:0002237 9.32 IL10 CXCL8
13 negative regulation of cytokine production involved in immune response GO:0002719 9.26 IL10 APOA1
14 negative regulation of cytokine secretion involved in immune response GO:0002740 9.16 IL10 APOA1
15 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.13 MMP9 MMP2 IL10
16 cytokine-mediated signaling pathway GO:0019221 9.02 MMP9 MMP2 IL6 IL10 CXCL8

Molecular functions related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL6 IL10 CXCL8

Sources for Acute Transverse Myelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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