MCID: ACT043
MIFTS: 27

Acute Urate Nephropathy

Categories: Nephrological diseases

Aliases & Classifications for Acute Urate Nephropathy

MalaCards integrated aliases for Acute Urate Nephropathy:

Name: Acute Urate Nephropathy 12 15 74
Uric Acid Urolithiasis 12 74
Uric Acid Nephrolithiasis 12
Uric Acid Renal Calculus 74

Classifications:



External Ids:

Disease Ontology 12 DOID:580
ICD9CM 36 274.11
SNOMED-CT 69 16410004

Summaries for Acute Urate Nephropathy

MalaCards based summary : Acute Urate Nephropathy, also known as uric acid urolithiasis, is related to nephrolithiasis and gout. An important gene associated with Acute Urate Nephropathy is ZNF365 (Zinc Finger Protein 365). The drugs Sodium Citrate and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include kidney.

Related Diseases for Acute Urate Nephropathy

Diseases related to Acute Urate Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 nephrolithiasis 30.6 SLC22A12 ZNF365
2 gout 29.4 CARMIL1 SLC22A12
3 nephrolithiasis, uric acid 12.5
4 phosphoribosylpyrophosphate synthetase superactivity 11.4
5 diabetes mellitus, noninsulin-dependent 10.2
6 factitious disorder 10.0
7 cystinuria 10.0
8 hepatitis 10.0
9 renal tubular acidosis 10.0
10 hepatitis c 10.0
11 hyperuricemia 10.0
12 acute diarrhea 10.0
13 diarrhea 10.0

Graphical network of the top 20 diseases related to Acute Urate Nephropathy:



Diseases related to Acute Urate Nephropathy

Symptoms & Phenotypes for Acute Urate Nephropathy

Drugs & Therapeutics for Acute Urate Nephropathy

Drugs for Acute Urate Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium Citrate Approved, Investigational Phase 4 68-04-2
2
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
3
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
4
tannic acid Approved Phase 4 1401-55-4
5
Allopurinol Approved Phase 4 315-30-0 2094
6
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
7
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
8
Uric Acid Experimental, Investigational Phase 4,Not Applicable 69-93-2 1175
9 Antioxidants Phase 4,Not Applicable
10 Expectorants Phase 4
11 Antimetabolites Phase 4
12 Free Radical Scavengers Phase 4
13 Natriuretic Agents Phase 4
14 Chelating Agents Phase 4
15 Citrate Phase 4
16 Anticoagulants Phase 4
17 Calcium, Dietary Phase 4
18 Respiratory System Agents Phase 4
19 diuretics Phase 4
20 Antirheumatic Agents Phase 4
21 Protective Agents Phase 4,Not Applicable
22
Pioglitazone Approved, Investigational Not Applicable 111025-46-8 4829
23
Zinc Approved, Investigational 7440-66-6 32051
24
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
25
2,4-thiazolidinedione Investigational Not Applicable 2295-31-0
26 Technetium Tc 99m Mertiatide Not Applicable
27 Radiopharmaceuticals Not Applicable
28 Hypoglycemic Agents Not Applicable
29 Retinol palmitate
30 Vitamins
31 retinol

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Predictors of Successful Oral Dissolution Therapy in Radiolucent Renal Stones; A Prospective Evaluation Completed NCT02373384 Phase 4 Oral alkalinization (Potassium citrate, Allopurinol)
2 Screening and Identification of Human Urate Transporter hURAT1 MicroRNA Unknown status NCT01973088
3 The Links Between Water and Salt Intake, Body Weight, Hypertension and Kidney Stones: a Difficult Puzzle Unknown status NCT01100580 Not Applicable
4 Toxicity of Perirenal Fat in Overweight or Obese Subjects: A Pathophysiological Link Between Uric Acid Stones and Renal Ammonium Formation Completed NCT02561858 Not Applicable
5 The Mineral Water of Vichy and the Urinary Alkalization: A Study of the Dose - Effect of Bicarbonate Salt Water on the Urinary pH in Healthy Volunteers Completed NCT02509780 Not Applicable
6 Renal Uptake of Fatty Acids (FFA) in Patients With Idiopathic Uric Acid Nephrolithiasis (IUAN) Recruiting NCT02975986 Not Applicable
7 Pathophysiology of Uric Acid Nephrolithiasis Recruiting NCT00904046 Not Applicable Pioglitazone;Placebo
8 Study of the Crystallization Inhibition Capacity of the Uric Acid in Urine in a Group of Lithiasic Patients After Intake of a Food Supplement Recruiting NCT03483532

Search NIH Clinical Center for Acute Urate Nephropathy

Genetic Tests for Acute Urate Nephropathy

Anatomical Context for Acute Urate Nephropathy

MalaCards organs/tissues related to Acute Urate Nephropathy:

42
Kidney

Publications for Acute Urate Nephropathy

Articles related to Acute Urate Nephropathy:

(show all 18)
# Title Authors Year
1
Epidemiology, pathophysiology, and management of uric acid urolithiasis: A narrative review. ( 28748117 )
2017
2
Seizure-induced acute urate nephropathy: case report and review. ( 23918111 )
2013
3
Overweight, insulin resistance and blood pressure (parameters of the metabolic syndrome) in uric acid urolithiasis. ( 21866382 )
2012
4
Acute urate nephropathy precipitated by acute diarrhea. ( 19736489 )
2009
5
Clinical study of uric acid urolithiasis. ( 17525014 )
2007
6
Uric acid urolithiasis and crystallization inhibitors. ( 10567882 )
1999
7
Purine metabolism of uric acid urolithiasis induced in newborn piglets. ( 9524944 )
1998
8
Acute urate nephropathy due to partial hypoxanthine-guanine phosphoribosyl transferase deficiency. ( 2115630 )
1990
9
Uric acid urolithiasis in a Dalmatian coach hound. ( 7175910 )
1982
10
Acute urate nephropathy induced by Ticrynafen and exacerbated by urographic contrast medium. ( 7281384 )
1981
11
Sulfinpyrazone induced uric acid urolithiasis with acute renal failure. ( 7249646 )
1981
12
Intrarenal dynamics in the pathogenesis and prevention of acute urate nephropathy. ( 16037 )
1977
13
A micropuncture study of the early phase of acute urate nephropathy. ( 956394 )
1976
14
Factitious uric acid urolithiasis as a feature of the Munchausen syndrome. ( 4547206 )
1974
15
The treatment of uric acid urolithiasis with particular reference to the southwestern U.S.A. ( 5412499 )
1970
16
The etiology of uric acid urolithiasis following ileostomy. ( 4980097 )
1969
17
Treatment of uric acid urolithiasis with allopurinol: a xanthine oxidase inhibitor. ( 6018432 )
1967
18
Pathogenesis of uric acid urolithiasis. ( 13982024 )
1962

Variations for Acute Urate Nephropathy

Expression for Acute Urate Nephropathy

Search GEO for disease gene expression data for Acute Urate Nephropathy.

Pathways for Acute Urate Nephropathy

GO Terms for Acute Urate Nephropathy

Cellular components related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brush border membrane GO:0031526 8.62 SLC22A12 SLC9A3

Biological processes related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 urate metabolic process GO:0046415 8.62 CARMIL1 SLC22A12

Molecular functions related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PDZ domain binding GO:0030165 8.62 SLC22A12 SLC9A3

Sources for Acute Urate Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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