MCID: ACT043
MIFTS: 27

Acute Urate Nephropathy

Categories: Nephrological diseases

Aliases & Classifications for Acute Urate Nephropathy

MalaCards integrated aliases for Acute Urate Nephropathy:

Name: Acute Urate Nephropathy 12 15 73
Uric Acid Nephrolithiasis, Susceptibility to 29 6
Uric Acid Nephrolithiasis 12 55
Uric Acid Urolithiasis 12 73
Uric Acid Renal Calculus 73

Classifications:



External Ids:

Disease Ontology 12 DOID:580
ICD9CM 35 274.11
SNOMED-CT 68 16410004

Summaries for Acute Urate Nephropathy

MalaCards based summary : Acute Urate Nephropathy, also known as uric acid nephrolithiasis, susceptibility to, is related to nephrolithiasis and nephrolithiasis, uric acid. An important gene associated with Acute Urate Nephropathy is ZNF365 (Zinc Finger Protein 365), and among its related pathways/superpathways is Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Related phenotype is renal/urinary system.

Related Diseases for Acute Urate Nephropathy

Diseases related to Acute Urate Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 nephrolithiasis 30.8 SLC22A12 ZNF365
2 nephrolithiasis, uric acid 12.1
3 phosphoribosylpyrophosphate synthetase superactivity 11.3
4 factitious disorder 10.0
5 cystinuria 10.0
6 hepatitis 10.0
7 renal tubular acidosis 10.0
8 hepatitis c 10.0
9 hyperuricemia 10.0
10 acute diarrhea 10.0
11 diarrhea 10.0
12 gout 9.8 CARMIL1 SLC22A12

Graphical network of the top 20 diseases related to Acute Urate Nephropathy:



Diseases related to Acute Urate Nephropathy

Symptoms & Phenotypes for Acute Urate Nephropathy

MGI Mouse Phenotypes related to Acute Urate Nephropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.8 RHCG SLC22A12 SLC9A3

Drugs & Therapeutics for Acute Urate Nephropathy

Search Clinical Trials , NIH Clinical Center for Acute Urate Nephropathy

Genetic Tests for Acute Urate Nephropathy

Genetic tests related to Acute Urate Nephropathy:

# Genetic test Affiliating Genes
1 Uric Acid Nephrolithiasis, Susceptibility to 29 ZNF365

Anatomical Context for Acute Urate Nephropathy

Publications for Acute Urate Nephropathy

Articles related to Acute Urate Nephropathy:

# Title Authors Year
1
Seizure-induced acute urate nephropathy: case report and review. ( 23918111 )
2013
2
Acute urate nephropathy precipitated by acute diarrhea. ( 19736489 )
2009
3
Acute urate nephropathy due to partial hypoxanthine-guanine phosphoribosyl transferase deficiency. ( 2115630 )
1990
4
Acute urate nephropathy induced by Ticrynafen and exacerbated by urographic contrast medium. ( 7281384 )
1981
5
Intrarenal dynamics in the pathogenesis and prevention of acute urate nephropathy. ( 16037 )
1977
6
A micropuncture study of the early phase of acute urate nephropathy. ( 956394 )
1976

Variations for Acute Urate Nephropathy

ClinVar genetic disease variations for Acute Urate Nephropathy:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ZNF365 NM_199452.3(ZNF365): c.184G> A (p.Ala62Thr) single nucleotide variant risk factor rs7076156 GRCh37 Chromosome 10, 64415184: 64415184
2 ZNF365 NM_199452.3(ZNF365): c.184G> A (p.Ala62Thr) single nucleotide variant risk factor rs7076156 GRCh38 Chromosome 10, 62655424: 62655424

Expression for Acute Urate Nephropathy

Search GEO for disease gene expression data for Acute Urate Nephropathy.

GO Terms for Acute Urate Nephropathy

Cellular components related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.46 CARMIL1 RHCG SLC22A12 SLC9A3
2 brush border membrane GO:0031526 8.96 SLC22A12 SLC9A3
3 apical plasma membrane GO:0016324 8.8 RHCG SLC22A12 SLC9A3

Biological processes related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of pH GO:0006885 8.96 RHCG SLC9A3
2 urate metabolic process GO:0046415 8.62 CARMIL1 SLC22A12

Molecular functions related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PDZ domain binding GO:0030165 8.62 SLC22A12 SLC9A3

Sources for Acute Urate Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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