MCID: ACT060
MIFTS: 39

Acute Vascular Insufficiency of Intestine

Categories: Gastrointestinal diseases, Cardiovascular diseases

Aliases & Classifications for Acute Vascular Insufficiency of Intestine

MalaCards integrated aliases for Acute Vascular Insufficiency of Intestine:

Name: Acute Vascular Insufficiency of Intestine 12 15 73
Acute Gastrointestinal Tract Vascular Insuffic. 12
Acute Intestinal Vascular Insufficiency 12
Acute Git Vascular Insuffic. 12
Acute Intestinal Ischemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8590
ICD9CM 35 557.0
NCIt 50 C34356
UMLS 73 C0001363

Summaries for Acute Vascular Insufficiency of Intestine

MalaCards based summary : Acute Vascular Insufficiency of Intestine, also known as acute gastrointestinal tract vascular insuffic., is related to scorpion envenomation and leukomalacia. An important gene associated with Acute Vascular Insufficiency of Intestine is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Allograft rejection and Immune response IL-23 signaling pathway. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include lung and kidney, and related phenotypes are growth/size/body region and behavior/neurological

Related Diseases for Acute Vascular Insufficiency of Intestine

Diseases related to Acute Vascular Insufficiency of Intestine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 scorpion envenomation 10.7 IL6 TNF
2 leukomalacia 10.6 IL6 TNF
3 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL6 TNF
4 critical limb ischemia 10.6 IL6 TNF
5 streptococcal toxic-shock syndrome 10.6 IL6 TNF
6 recurrent corneal erosion 10.6 IL1B IL6
7 null-cell leukemia 10.6 IL6 TNF
8 bagassosis 10.6 IL1B IL6
9 periodontitis, chronic 10.5 IL1B IL6
10 retinitis pigmentosa 55 10.5 IL6 TNF
11 anca-associated vasculitis 10.5 IL6 TNF
12 uremic pruritus 10.5 IL1B IL6
13 funisitis 10.4 IL1B IL6
14 systemic onset juvenile idiopathic arthritis 10.4 IL1B TNF
15 glossitis 10.4 IL1B IL6
16 euthyroid sick syndrome 10.4 IL1B IL6
17 staphylococcal toxic shock syndrome 10.4 IL1B TNF
18 ileitis 10.4 FABP2 IL6 TNF
19 autoimmune myocarditis 10.4 IL1B TNF
20 kashin-beck disease 10.4 IL1B TNF
21 cerebral hemorrhage 10.4 IL1B SOD1
22 ascaris lumbricoides infection 10.4 IL1B IL6
23 posterior urethral valves 10.4 IL6 TNF
24 vulvar vestibulitis syndrome 10.4 IL1B TNF
25 louse-borne relapsing fever 10.4 IL6 MAPK1 TNF
26 burns 10.3 IL1B TNF
27 erysipelas 10.3 SOD1 TNF
28 haemophilus influenzae 10.3 IL1B TNF
29 retinitis pigmentosa 60 10.2 IL1B TNF
30 irritant dermatitis 10.2 IL1B TNF
31 laryngitis 10.2 IL1B IL6 TNF
32 poems syndrome 10.2 IL1B IL6 TNF
33 brain edema 10.2 IL1B IL6 SOD1
34 central nervous system vasculitis 10.2 IL1B IL6 TNF
35 osteosclerotic myeloma 10.2 IL1B IL6 TNF
36 stachybotrys chartarum 10.2 IL1B IL6 TNF
37 endometritis 10.2 IL1B IL6 TNF
38 joint disorders 10.2 IL1B IL6 TNF
39 pulpitis 10.2 IL1B IL6 TNF
40 commensal bacterial infectious disease 10.2 IL1B IL6 TNF
41 lacrimal apparatus disease 10.2 IL1B IL6 TNF
42 adult-onset still's disease 10.2 IL1B IL6 TNF
43 aphthous stomatitis 10.2 IL1B IL6 TNF
44 dengue shock syndrome 10.2 IL1B IL6 TNF
45 extrinsic cardiomyopathy 10.2 IL1B IL6 TNF
46 viral encephalitis 10.2 IL1B IL6 TNF
47 complex regional pain syndrome 10.2 IL1B IL6 TNF
48 idiopathic neutropenia 10.2 IL1B IL6 TNF
49 uterine anomalies 10.2 IL1B IL6 TNF
50 chikungunya 10.2 IL1B IL6 TNF

Comorbidity relations with Acute Vascular Insufficiency of Intestine via Phenotypic Disease Network (PDN): (show all 23)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Aortic Aneurysm Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intestinal Obstruction
Intestinal Perforation Intestinal Volvulus
Ischemic Heart Disease Paralytic Ileus
Peripheral Vascular Disease Peritonitis
Portal Vein Thrombosis Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Acute Vascular Insufficiency of Intestine:



Diseases related to Acute Vascular Insufficiency of Intestine

Symptoms & Phenotypes for Acute Vascular Insufficiency of Intestine

MGI Mouse Phenotypes related to Acute Vascular Insufficiency of Intestine:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.07 IL1B SOD1 IL6 CEP290 MAPK1 FABP2
2 behavior/neurological MP:0005386 10.06 HSPA4 OCLN IL6 CEP290 MAPK1 GDNF
3 cardiovascular system MP:0005385 10.03 IL1B SOD1 IL6 CEP290 MAPK1 GDNF
4 endocrine/exocrine gland MP:0005379 9.95 OCLN HSPA4 SOD1 IL6 MAPK1 GDNF
5 nervous system MP:0003631 9.85 HSPA4 IL1B SOD1 IL6 CEP290 MAPK1
6 liver/biliary system MP:0005370 9.8 SOD1 IL6 CEP290 FABP2 MAPK1 TNF
7 muscle MP:0005369 9.73 OCLN IL6 MAPK1 GDNF SOD1 TNF
8 reproductive system MP:0005389 9.56 HSPA4 SOD1 IL6 CEP290 MAPK1 GDNF
9 skeleton MP:0005390 9.17 OCLN IL1B SOD1 IL6 CEP290 MAPK1

Drugs & Therapeutics for Acute Vascular Insufficiency of Intestine

Drugs for Acute Vascular Insufficiency of Intestine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
2
Dalteparin Approved Phase 4 9005-49-6
3 calcium heparin Phase 4
4 Fibrinolytic Agents Phase 4
5 Heparin, Low-Molecular-Weight Phase 4
6 Anticoagulants Phase 4
7 Calcium, Dietary Phase 4
8
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
9
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
10 Respiratory System Agents Phase 2, Phase 3
11 Adrenergic Agents Phase 2, Phase 3
12 Adrenergic Agonists Phase 2, Phase 3
13 Adrenergic alpha-Agonists Phase 2, Phase 3
14 Adrenergic beta-Agonists Phase 2, Phase 3
15 Mydriatics Phase 2, Phase 3
16 Neurotransmitter Agents Phase 2, Phase 3
17 Vasoconstrictor Agents Phase 2, Phase 3
18 Anti-Asthmatic Agents Phase 2, Phase 3
19 Peripheral Nervous System Agents Phase 2, Phase 3
20 Epinephryl borate Phase 2, Phase 3
21 Autonomic Agents Phase 2, Phase 3
22 Bronchodilator Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Predictive Factors of Intestinal Infraction in Acute Mesenteric Ischemia Completed NCT02645240 Phase 4 Heparin injection
2 Liberal Transfusion Strategy in Elderly Patients Recruiting NCT03369210 Phase 3 red blood cell transfusion trigger
3 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Recruiting NCT03126968 Phase 2, Phase 3 Topical epinephrine;Placebos
4 Plasma i-FABP as Predictor for Irreversible Bowel Ischemia Unknown status NCT01788904
5 Kidney and Intestinal Markers for Early Detection of Organ Injury After Endovascular Aortic Repair Completed NCT01915446
6 Mesenteric Ischemia in the Emergency Department: a Retrospective Multicenter Study Recruiting NCT02772913
7 Multislice Computed Tomography Angiography in Acute Mesenteric Ischemia Not yet recruiting NCT03484442
8 Searching Biomarkers of Acute Intestinal Ischemic Injuries Not yet recruiting NCT03518099 Not Applicable

Search NIH Clinical Center for Acute Vascular Insufficiency of Intestine

Genetic Tests for Acute Vascular Insufficiency of Intestine

Anatomical Context for Acute Vascular Insufficiency of Intestine

MalaCards organs/tissues related to Acute Vascular Insufficiency of Intestine:

41
Lung, Kidney

Publications for Acute Vascular Insufficiency of Intestine

Variations for Acute Vascular Insufficiency of Intestine

Expression for Acute Vascular Insufficiency of Intestine

Search GEO for disease gene expression data for Acute Vascular Insufficiency of Intestine.

Pathways for Acute Vascular Insufficiency of Intestine

Pathways related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 GDNF HSPA4 IL1B IL6 MAPK1 TNF
2
Show member pathways
12.49 IL1B IL6 MAPK1 TNF
3
Show member pathways
12.36 IL1B IL6 MAPK1 TNF
4
Show member pathways
12.34 IL1B IL6 MAPK1 TNF
5
Show member pathways
12.25 IL1B IL6 SOD1 TNF
6
Show member pathways
12.24 IL1B IL6 MAPK1 TNF
7
Show member pathways
12.15 IL1B IL6 MAPK1 TNF
8 12.14 IL1B IL6 MAPK1 TNF
9
Show member pathways
12.12 IL1B IL6 MAPK1 TNF
10
Show member pathways
12.1 IL1B IL6 MAPK1 TNF
11
Show member pathways
12.08 IL1B IL6 TNF
12 12.08 IL6 MAPK1 TNF
13 12.07 IL1B IL6 TNF
14 11.97 MAPK1 OCLN TNF
15 11.95 IL1B MAPK1 TNF
16 11.9 IL1B IL6 TNF
17 11.86 IL1B IL6 MAPK1
18 11.81 IL1B IL6 TNF
19 11.8 IL1B IL6 TNF
20 11.77 IL1B IL6 TNF
21 11.77 IL1B IL6 MAPK1 TNF
22 11.67 IL1B IL6 TNF
23 11.66 IL1B IL6 MAPK1 TNF
24 11.6 IL1B IL6 TNF
25 11.56 IL1B IL6 MAPK1 TJP1
26 11.52 IL1B IL6 TNF
27 11.46 IL1B IL6 TNF
28 11.46 IL1B IL6 TNF
29 11.44 IL1B IL6 MAPK1 TNF
30 11.43 GDNF IL1B IL6 MAPK1 TNF
31 11.4 IL1B IL6 TNF
32 11.26 IL1B IL6 TNF
33
Show member pathways
11.26 IL1B IL6 MAPK1 TNF
34 11.24 IL1B IL6 TNF
35 11.19 IL1B IL6 TNF
36 11.16 IL1B IL6 TNF
37 11.13 IL1B IL6 TNF
38 11.06 MAPK1 TNF
39 11.02 IL6 TNF
40 10.95 IL6 TNF
41 10.92 IL1B MAPK1 TNF
42 10.87 IL1B TNF
43 10.47 IL1B IL6 MAPK1 SOD1

GO Terms for Acute Vascular Insufficiency of Intestine

Cellular components related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CEP290 GDNF IL1B IL6 MAPK1 SOD1
2 protein-containing complex GO:0032991 9.02 CEP290 GOT2 MAPK1 SOD1 TJP1
3 apicolateral plasma membrane GO:0016327 8.96 OCLN TJP1

Biological processes related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.91 GDNF IL1B IL6 TNF
2 positive regulation of transcription, DNA-templated GO:0045893 9.91 CEP290 IL1B IL6 MAPK1 TNF
3 positive regulation of gene expression GO:0010628 9.88 IL1B IL6 MAPK1 TNF
4 MAPK cascade GO:0000165 9.78 GDNF IL1B MAPK1 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 IL1B IL6 TNF
6 response to ethanol GO:0045471 9.73 GOT2 SOD1 TJP1
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.72 IL1B IL6 TNF
8 positive regulation of chemokine production GO:0032722 9.59 IL6 TNF
9 negative regulation of lipid catabolic process GO:0050995 9.58 IL1B TNF
10 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 IL1B TNF
11 regulation of bicellular tight junction assembly GO:2000810 9.54 OCLN TJP1
12 positive regulation of interleukin-6 production GO:0032755 9.54 IL1B IL6 TNF
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 IL1B TNF
14 negative regulation of lipid storage GO:0010888 9.49 IL6 TNF
15 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL1B TNF
16 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
17 positive regulation of fever generation GO:0031622 9.4 IL1B TNF
18 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.33 GDNF IL1B TNF
19 sequestering of triglyceride GO:0030730 9.32 IL1B TNF
20 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.13 IL1B MAPK1 TNF
22 activation of MAPK activity GO:0000187 8.92 IL1B MAPK1 SOD1 TNF

Sources for Acute Vascular Insufficiency of Intestine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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