MCID: ACT060
MIFTS: 42

Acute Vascular Insufficiency of Intestine

Categories: Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Acute Vascular Insufficiency of Intestine

MalaCards integrated aliases for Acute Vascular Insufficiency of Intestine:

Name: Acute Vascular Insufficiency of Intestine 12 15 74
Acute Gastrointestinal Tract Vascular Insuffic. 12
Acute Intestinal Vascular Insufficiency 12
Acute Git Vascular Insuffic. 12
Acute Intestinal Ischemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8590
ICD9CM 36 557.0
NCIt 51 C34356
SNOMED-CT 69 91489000
UMLS 74 C0001363

Summaries for Acute Vascular Insufficiency of Intestine

MalaCards based summary : Acute Vascular Insufficiency of Intestine, also known as acute gastrointestinal tract vascular insuffic., is related to scorpion envenomation and leukomalacia. An important gene associated with Acute Vascular Insufficiency of Intestine is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include lung and kidney, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Acute Vascular Insufficiency of Intestine

Diseases related to Acute Vascular Insufficiency of Intestine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 scorpion envenomation 10.4 IL6 TNF
2 leukomalacia 10.3 IL6 TNF
3 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
4 autoimmune myocarditis 10.3 IL6 TNF
5 exudative glomerulonephritis 10.3 IL1B TNF
6 critical limb ischemia 10.3 IL6 TNF
7 streptococcal toxic-shock syndrome 10.3 IL6 TNF
8 juvenile ankylosing spondylitis 10.3 IL6 TNF
9 recurrent corneal erosion 10.3 IL1B IL6
10 cardiogenic shock 10.3 IL6 TNF
11 bagassosis 10.3 IL1B IL6
12 periodontitis, chronic 10.3 IL1B IL6
13 null-cell leukemia 10.3 IL6 TNF
14 staphylococcal toxic shock syndrome 10.3 IL1B TNF
15 retinitis pigmentosa 55 10.3 IL6 TNF
16 ileitis 10.3 FABP2 IL6 TNF
17 kashin-beck disease 10.3 IL1B TNF
18 vulvar vestibulitis syndrome 10.2 IL1B TNF
19 uremic pruritus 10.2 IL1B IL6
20 spinal cord disease 10.2 GDNF IL6 TNF
21 funisitis 10.2 IL1B IL6
22 burns 10.2 IL1B TNF
23 louse-borne relapsing fever 10.2 IL6 MAPK1 TNF
24 haemophilus influenzae 10.2 IL1B TNF
25 colitis 10.2 IL1B IL6 TNF
26 glossitis 10.2 IL1B IL6 TNF
27 laryngitis 10.2 IL1B IL6 TNF
28 osteosclerotic myeloma 10.2 IL1B IL6 TNF
29 poems syndrome 10.2 IL1B IL6 TNF
30 periapical periodontitis 10.2 IL1B IL6 TNF
31 periodontitis 10.2 IL1B IL6 TNF
32 autoimmune gastritis 10.2 IL1B IL6 TNF
33 central nervous system vasculitis 10.2 IL1B IL6 TNF
34 stachybotrys chartarum 10.2 IL1B IL6 TNF
35 opisthorchiasis 10.2 IL1B TNF
36 endometrial disease 10.2 IL1B IL6 TNF
37 eales disease 10.2 IL1B IL6 TNF
38 endometritis 10.2 IL1B IL6 TNF
39 pulpitis 10.2 IL1B IL6 TNF
40 joint disorders 10.2 IL1B IL6 TNF
41 middle ear disease 10.2 IL1B IL6 TNF
42 lacrimal apparatus disease 10.2 IL1B IL6 TNF
43 cerebral artery occlusion 10.2 GDNF IL1B TNF
44 adult-onset still's disease 10.2 IL1B IL6 TNF
45 commensal bacterial infectious disease 10.2 IL1B IL6 TNF
46 bacterial infectious disease 10.2 IL1B IL6 TNF
47 dengue shock syndrome 10.2 IL1B IL6 TNF
48 q fever 10.2 IL1B IL6 TNF
49 retinitis pigmentosa 60 10.2 IL1B TNF
50 euthyroid sick syndrome 10.2 IL1B IL6

Comorbidity relations with Acute Vascular Insufficiency of Intestine via Phenotypic Disease Network (PDN): (show all 23)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Aortic Aneurysm Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intestinal Obstruction
Intestinal Perforation Intestinal Volvulus
Ischemic Heart Disease Paralytic Ileus
Peripheral Vascular Disease Peritonitis
Portal Vein Thrombosis Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Acute Vascular Insufficiency of Intestine:



Diseases related to Acute Vascular Insufficiency of Intestine

Symptoms & Phenotypes for Acute Vascular Insufficiency of Intestine

MGI Mouse Phenotypes related to Acute Vascular Insufficiency of Intestine:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 CEP290 GDNF HPGDS HSPA4 IL6 MAPK1
2 growth/size/body region MP:0005378 10.18 CEP290 FABP2 GDNF IL1B IL6 MAPK1
3 homeostasis/metabolism MP:0005376 10.16 CEP290 FABP2 HPGDS IL1B IL6 MAPK1
4 cardiovascular system MP:0005385 10.11 CEP290 GDNF IL1B IL6 MAPK1 TAGLN
5 mortality/aging MP:0010768 10.1 CEP290 GDNF HPGDS HSPA4 IL1B IL6
6 immune system MP:0005387 10.09 CEP290 GDNF HPGDS IL1B IL6 MAPK1
7 nervous system MP:0003631 10 CEP290 GDNF HPGDS HSPA4 IL1B IL6
8 digestive/alimentary MP:0005381 9.97 GDNF IL6 MAPK1 OCLN TAGLN TNF
9 muscle MP:0005369 9.85 GDNF IL6 MAPK1 OCLN TAGLN TNF
10 neoplasm MP:0002006 9.8 HPGDS IL1B IL6 MAPK1 TAGLN TNF
11 renal/urinary system MP:0005367 9.63 CEP290 FABP2 GDNF IL6 TAGLN TJP1
12 reproductive system MP:0005389 9.56 CEP290 GDNF HSPA4 IL6 MAPK1 OCLN
13 skeleton MP:0005390 9.17 CEP290 IL1B IL6 MAPK1 OCLN TAGLN

Drugs & Therapeutics for Acute Vascular Insufficiency of Intestine

Drugs for Acute Vascular Insufficiency of Intestine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
2
Dalteparin Approved Phase 4 9005-49-6
3
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
4 calcium heparin Phase 4
5 Fibrinolytic Agents Phase 4
6 Heparin, Low-Molecular-Weight Phase 4
7 Anticoagulants Phase 4
8 Calcium, Dietary Phase 4
9
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
10
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
11 Respiratory System Agents Phase 2, Phase 3
12 Adrenergic Agents Phase 2, Phase 3
13 Bronchodilator Agents Phase 2, Phase 3
14 Adrenergic alpha-Agonists Phase 2, Phase 3
15 Epinephryl borate Phase 2, Phase 3
16 Neurotransmitter Agents Phase 2, Phase 3
17 Sympathomimetics Phase 2, Phase 3
18 Adrenergic Agonists Phase 2, Phase 3
19 Vasoconstrictor Agents Phase 2, Phase 3
20 Anti-Asthmatic Agents Phase 2, Phase 3
21 Autonomic Agents Phase 2, Phase 3
22 Adrenergic beta-Agonists Phase 2, Phase 3
23 Peripheral Nervous System Agents Phase 2, Phase 3
24 Mydriatics Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Predictive Factors of Intestinal Infraction in Acute Mesenteric Ischemia Completed NCT02645240 Phase 4 Heparin injection
2 Liberal Transfusion Strategy in Elderly Patients Recruiting NCT03369210 Phase 3 red blood cell transfusion trigger
3 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Recruiting NCT03126968 Phase 2, Phase 3 Topical epinephrine;Placebos
4 Plasma i-FABP as Predictor for Irreversible Bowel Ischemia Unknown status NCT01788904
5 Kidney and Intestinal Markers for Early Detection of Organ Injury After Endovascular Aortic Repair Completed NCT01915446
6 Mesenteric Ischemia in the Emergency Department: a Retrospective Multicenter Study Recruiting NCT02772913
7 Searching Biomarkers of Acute Intestinal Ischemic Injuries Recruiting NCT03518099 Not Applicable
8 Evaluation of Covered Stents Versus Bare Metal Stents for Endovascular Treatment of Chronic Ischemia Mesenteric Disease. Recruiting NCT03586739 Not Applicable
9 Multislice Computed Tomography Angiography in Acute Mesenteric Ischemia Not yet recruiting NCT03484442

Search NIH Clinical Center for Acute Vascular Insufficiency of Intestine

Genetic Tests for Acute Vascular Insufficiency of Intestine

Anatomical Context for Acute Vascular Insufficiency of Intestine

MalaCards organs/tissues related to Acute Vascular Insufficiency of Intestine:

42
Lung, Kidney

Publications for Acute Vascular Insufficiency of Intestine

Articles related to Acute Vascular Insufficiency of Intestine:

# Title Authors Year
1
Biochemical markers of acute intestinal ischemia: possibilities and limitations. ( 30306080 )
2018
2
Oral contraceptive and acute intestinal ischemia with mesenteric venous thrombosis: a case report. ( 29386950 )
2017
3
Midgut neuroendocrine tumor presenting with acute intestinal ischemia. ( 29259385 )
2017

Variations for Acute Vascular Insufficiency of Intestine

Expression for Acute Vascular Insufficiency of Intestine

Search GEO for disease gene expression data for Acute Vascular Insufficiency of Intestine.

Pathways for Acute Vascular Insufficiency of Intestine

Pathways related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 GDNF HSPA4 IL1B IL6 MAPK1 TNF
2
Show member pathways
12.5 IL1B IL6 MAPK1 TNF
3
Show member pathways
12.49 IL1B IL6 MAPK1 TNF
4
Show member pathways
12.35 IL1B IL6 MAPK1 TNF
5
Show member pathways
12.24 IL1B IL6 MAPK1 TNF
6
Show member pathways
12.23 IL1B IL6 MAPK1 TNF
7 12.13 IL1B IL6 MAPK1 TNF
8
Show member pathways
12.11 IL1B IL6 MAPK1 TNF
9
Show member pathways
12.09 IL1B IL6 MAPK1 TNF
10
Show member pathways
11.97 IL1B IL6 TNF
11 11.96 IL1B MAPK1 TNF
12
Show member pathways
11.95 IL1B IL6 TNF
13 11.9 IL1B IL6 TNF
14 11.86 IL1B IL6 MAPK1
15 11.81 IL1B IL6 TNF
16 11.8 IL1B IL6 TNF
17 11.78 IL1B IL6 TNF
18 11.75 IL1B IL6 MAPK1 TNF
19 11.67 IL1B IL6 TNF
20 11.65 IL1B IL6 TNF
21 11.62 IL1B IL6 MAPK1 TNF
22 11.59 IL1B IL6 TNF
23 11.52 IL1B IL6 TNF
24 11.49 IL1B IL6 MAPK1 TJP1
25 11.46 IL1B IL6 TNF
26 11.46 IL1B IL6 TNF
27 11.44 HPGDS MAPK1 TNF
28 11.39 IL1B IL6 TNF
29 11.34 IL1B IL6 MAPK1 TNF
30 11.28 IL1B IL6 TNF
31 11.24 IL1B IL6 TNF
32 11.23 IL1B IL6 MAPK1
33 11.18 IL1B IL6 TNF
34 11.14 IL1B IL6 TNF
35 11.1 IL1B IL6 TNF
36 11.1 GDNF IL1B IL6 MAPK1 TNF
37 11.07 MAPK1 TNF
38
Show member pathways
11.06 IL1B IL6 MAPK1 TNF
39 11.03 IL6 TNF
40 10.96 IL6 TNF
41 10.89 IL1B MAPK1 TNF
42 10.87 IL1B TNF

GO Terms for Acute Vascular Insufficiency of Intestine

Cellular components related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apicolateral plasma membrane GO:0016327 8.62 OCLN TJP1

Biological processes related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.96 CEP290 IL1B IL6 MAPK1 TNF
2 positive regulation of gene expression GO:0010628 9.93 IL1B IL6 MAPK1 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL1B IL6 TNF
4 MAPK cascade GO:0000165 9.8 GDNF IL1B MAPK1 TNF
5 activation of MAPK activity GO:0000187 9.78 IL1B MAPK1 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.75 IL1B IL6 TNF
7 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL6 TNF
8 positive regulation of chemokine production GO:0032722 9.62 IL6 TNF
9 negative regulation of lipid catabolic process GO:0050995 9.62 IL1B TNF
10 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.61 IL1B TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IL1B TNF
12 response to ethanol GO:0045471 9.59 GOT2 TJP1
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
14 regulation of bicellular tight junction assembly GO:2000810 9.57 OCLN TJP1
15 negative regulation of lipid storage GO:0010888 9.55 IL6 TNF
16 positive regulation of chemokine biosynthetic process GO:0045080 9.54 IL1B TNF
17 regulation of establishment of endothelial barrier GO:1903140 9.52 IL1B TNF
18 response to glucocorticoid GO:0051384 9.51 IL6 TNF
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.5 GDNF IL1B TNF
20 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 IL1B MAPK1 TNF
22 sequestering of triglyceride GO:0030730 9.4 IL1B TNF
23 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IL1B TNF
24 negative regulation of neurogenesis GO:0050768 9.33 IL1B IL6 TNF
25 chronic inflammatory response to antigenic stimulus GO:0002439 9.13 TNF
26 positive regulation of glial cell proliferation GO:0060252 9.13 IL1B IL6 TNF
27 positive regulation of neuroinflammatory response GO:0150078 8.8 IL1B IL6 TNF

Sources for Acute Vascular Insufficiency of Intestine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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