MCID: ACT060
MIFTS: 39

Acute Vascular Insufficiency of Intestine

Categories: Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Acute Vascular Insufficiency of Intestine

MalaCards integrated aliases for Acute Vascular Insufficiency of Intestine:

Name: Acute Vascular Insufficiency of Intestine 12 15 73
Acute Gastrointestinal Tract Vascular Insuffic. 12
Acute Intestinal Vascular Insufficiency 12
Acute Git Vascular Insuffic. 12
Acute Intestinal Ischemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8590
ICD9CM 35 557.0
NCIt 50 C34356
SNOMED-CT 68 91489000
UMLS 73 C0001363

Summaries for Acute Vascular Insufficiency of Intestine

MalaCards based summary : Acute Vascular Insufficiency of Intestine, also known as acute gastrointestinal tract vascular insuffic., is related to scorpion envenomation and leukomalacia. An important gene associated with Acute Vascular Insufficiency of Intestine is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Acute Vascular Insufficiency of Intestine

Diseases related to Acute Vascular Insufficiency of Intestine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 scorpion envenomation 10.2 IL6 TNF
2 leukomalacia 10.2 IL6 TNF
3 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
4 recurrent corneal erosion 10.2 IL1B IL6
5 critical limb ischemia 10.2 IL6 TNF
6 streptococcal toxic-shock syndrome 10.2 IL6 TNF
7 exudative glomerulonephritis 10.2 IL1B TNF
8 bagassosis 10.2 IL1B IL6
9 juvenile ankylosing spondylitis 10.2 IL6 TNF
10 cardiogenic shock 10.2 IL6 TNF
11 paraneoplastic syndromes 10.2 IL1B IL6
12 periodontitis, chronic 10.2 IL1B IL6
13 null-cell leukemia 10.2 IL6 TNF
14 staphylococcal toxic shock syndrome 10.2 IL1B TNF
15 retinitis pigmentosa 55 10.2 IL6 TNF
16 anca-associated vasculitis 10.2 IL6 TNF
17 ileitis 10.2 FABP2 IL6 TNF
18 kashin-beck disease 10.2 IL1B TNF
19 uremic pruritus 10.2 IL1B IL6
20 rheumatoid lung disease 10.2 IL1B TNF
21 vulvar vestibulitis syndrome 10.2 IL1B TNF
22 funisitis 10.2 IL1B IL6
23 anterior uveitis 10.1 IL6 TNF
24 burns 10.1 IL1B TNF
25 spinal cord disease 10.1 GDNF IL6 TNF
26 louse-borne relapsing fever 10.1 IL6 MAPK1 TNF
27 cerebral artery occlusion 10.1 GDNF MAPK1 TNF
28 haemophilus influenzae 10.1 IL1B TNF
29 colitis 10.1 IL1B IL6 TNF
30 glossitis 10.1 IL1B IL6 TNF
31 laryngitis 10.1 IL1B IL6 TNF
32 osteosclerotic myeloma 10.1 IL1B IL6 TNF
33 poems syndrome 10.1 IL1B IL6 TNF
34 periapical periodontitis 10.1 IL1B IL6 TNF
35 periodontitis 10.1 IL1B IL6 TNF
36 central nervous system vasculitis 10.1 IL1B IL6 TNF
37 stachybotrys chartarum 10.1 IL1B IL6 TNF
38 endometrial disease 10.1 IL1B IL6 TNF
39 opisthorchiasis 10.1 IL1B TNF
40 eales disease 10.1 IL1B IL6 TNF
41 endometritis 10.1 IL1B IL6 TNF
42 pulpitis 10.1 IL1B IL6 TNF
43 joint disorders 10.1 IL1B IL6 TNF
44 middle ear disease 10.1 IL1B IL6 TNF
45 lacrimal apparatus disease 10.1 IL1B IL6 TNF
46 adult-onset still's disease 10.1 IL1B IL6 TNF
47 commensal bacterial infectious disease 10.1 IL1B IL6 TNF
48 bacterial infectious disease 10.1 IL1B IL6 TNF
49 dengue shock syndrome 10.1 IL1B IL6 TNF
50 q fever 10.1 IL1B IL6 TNF

Comorbidity relations with Acute Vascular Insufficiency of Intestine via Phenotypic Disease Network (PDN): (show all 23)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Aortic Aneurysm Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intestinal Obstruction
Intestinal Perforation Intestinal Volvulus
Ischemic Heart Disease Paralytic Ileus
Peripheral Vascular Disease Peritonitis
Portal Vein Thrombosis Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Acute Vascular Insufficiency of Intestine:



Diseases related to Acute Vascular Insufficiency of Intestine

Symptoms & Phenotypes for Acute Vascular Insufficiency of Intestine

MGI Mouse Phenotypes related to Acute Vascular Insufficiency of Intestine:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 CEP290 GDNF HPGDS HSPA4 IL6 MAPK1
2 growth/size/body region MP:0005378 10.18 CEP290 FABP2 GDNF IL1B IL6 MAPK1
3 homeostasis/metabolism MP:0005376 10.16 CEP290 FABP2 HPGDS IL1B IL6 MAPK1
4 cardiovascular system MP:0005385 10.11 CEP290 GDNF IL1B IL6 MAPK1 TAGLN
5 mortality/aging MP:0010768 10.1 CEP290 GDNF HPGDS HSPA4 IL1B IL6
6 immune system MP:0005387 10.09 CEP290 GDNF HPGDS IL1B IL6 MAPK1
7 nervous system MP:0003631 10 CEP290 GDNF HPGDS HSPA4 IL1B IL6
8 digestive/alimentary MP:0005381 9.97 GDNF IL6 MAPK1 OCLN TAGLN TNF
9 muscle MP:0005369 9.85 GDNF IL6 MAPK1 OCLN TAGLN TNF
10 neoplasm MP:0002006 9.8 HPGDS IL1B IL6 MAPK1 TAGLN TNF
11 renal/urinary system MP:0005367 9.63 CEP290 FABP2 GDNF IL6 TAGLN TJP1
12 reproductive system MP:0005389 9.56 CEP290 GDNF HSPA4 IL6 MAPK1 OCLN
13 skeleton MP:0005390 9.17 CEP290 IL1B IL6 MAPK1 OCLN TAGLN

Drugs & Therapeutics for Acute Vascular Insufficiency of Intestine

Drugs for Acute Vascular Insufficiency of Intestine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
2
Dalteparin Approved Phase 4 9005-49-6
3 Calcium, Dietary Phase 4
4 Anticoagulants Phase 4
5 Heparin, Low-Molecular-Weight Phase 4
6 Fibrinolytic Agents Phase 4
7 calcium heparin Phase 4
8
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
9
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
10 Adrenergic beta-Agonists Phase 2, Phase 3
11 Vasoconstrictor Agents Phase 2, Phase 3
12 Autonomic Agents Phase 2, Phase 3
13 Anti-Asthmatic Agents Phase 2, Phase 3
14 Mydriatics Phase 2, Phase 3
15 Adrenergic Agonists Phase 2, Phase 3
16 Adrenergic alpha-Agonists Phase 2, Phase 3
17 Respiratory System Agents Phase 2, Phase 3
18 Sympathomimetics Phase 2, Phase 3
19 Neurotransmitter Agents Phase 2, Phase 3
20 Epinephryl borate Phase 2, Phase 3
21 Adrenergic Agents Phase 2, Phase 3
22 Peripheral Nervous System Agents Phase 2, Phase 3
23 Bronchodilator Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Predictive Factors of Intestinal Infraction in Acute Mesenteric Ischemia Completed NCT02645240 Phase 4 Heparin injection
2 Liberal Transfusion Strategy in Elderly Patients Recruiting NCT03369210 Phase 3 red blood cell transfusion trigger
3 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Recruiting NCT03126968 Phase 2, Phase 3 Topical epinephrine;Placebos
4 Plasma i-FABP as Predictor for Irreversible Bowel Ischemia Unknown status NCT01788904
5 Kidney and Intestinal Markers for Early Detection of Organ Injury After Endovascular Aortic Repair Completed NCT01915446
6 Mesenteric Ischemia in the Emergency Department: a Retrospective Multicenter Study Recruiting NCT02772913
7 Searching Biomarkers of Acute Intestinal Ischemic Injuries Recruiting NCT03518099 Not Applicable
8 Evaluation of Covered Stents Versus Bare Metal Stents for Endovascular Treatment of Chronic Ischemia Mesenteric Disease. Recruiting NCT03586739 Not Applicable
9 Multislice Computed Tomography Angiography in Acute Mesenteric Ischemia Not yet recruiting NCT03484442

Search NIH Clinical Center for Acute Vascular Insufficiency of Intestine

Genetic Tests for Acute Vascular Insufficiency of Intestine

Anatomical Context for Acute Vascular Insufficiency of Intestine

MalaCards organs/tissues related to Acute Vascular Insufficiency of Intestine:

41
Lung, Liver, Bone, Heart, Lymph Node, Eye, Spinal Cord

Publications for Acute Vascular Insufficiency of Intestine

Articles related to Acute Vascular Insufficiency of Intestine:

# Title Authors Year
1
Biochemical markers of acute intestinal ischemia: possibilities and limitations. ( 30306080 )
2018
2
Midgut neuroendocrine tumor presenting with acute intestinal ischemia. ( 29259385 )
2017
3
Oral contraceptive and acute intestinal ischemia with mesenteric venous thrombosis: a case report. ( 29386950 )
2017

Variations for Acute Vascular Insufficiency of Intestine

Expression for Acute Vascular Insufficiency of Intestine

Search GEO for disease gene expression data for Acute Vascular Insufficiency of Intestine.

Pathways for Acute Vascular Insufficiency of Intestine

Pathways related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 GDNF HSPA4 IL1B IL6 MAPK1 TNF
2
Show member pathways
12.5 IL1B IL6 MAPK1 TNF
3
Show member pathways
12.49 IL1B IL6 MAPK1 TNF
4
Show member pathways
12.35 IL1B IL6 MAPK1 TNF
5
Show member pathways
12.24 IL1B IL6 MAPK1 TNF
6
Show member pathways
12.23 IL1B IL6 MAPK1 TNF
7 12.13 IL1B IL6 MAPK1 TNF
8
Show member pathways
12.11 IL1B IL6 MAPK1 TNF
9
Show member pathways
12.1 IL1B IL6 MAPK1 TNF
10 11.98 MAPK1 OCLN TNF
11
Show member pathways
11.97 IL1B IL6 TNF
12 11.96 IL1B MAPK1 TNF
13
Show member pathways
11.95 IL1B IL6 TNF
14 11.9 IL1B IL6 TNF
15 11.86 IL1B IL6 MAPK1
16 11.81 IL1B IL6 TNF
17 11.8 IL1B IL6 TNF
18 11.77 IL1B IL6 TNF
19 11.75 IL1B IL6 MAPK1 TNF
20 11.67 IL1B IL6 TNF
21 11.65 IL1B IL6 TNF
22 11.62 IL1B IL6 MAPK1 TNF
23 11.59 IL1B IL6 TNF
24 11.52 IL1B IL6 TNF
25 11.49 IL1B IL6 MAPK1 TJP1
26 11.46 IL1B IL6 TNF
27 11.46 IL1B IL6 TNF
28 11.44 HPGDS MAPK1 TNF
29 11.38 IL1B IL6 TNF
30 11.34 IL1B IL6 MAPK1 TNF
31 11.26 IL1B IL6 TNF
32 11.24 IL1B IL6 TNF
33 11.23 IL1B IL6 MAPK1
34 11.18 IL1B IL6 TNF
35 11.14 IL1B IL6 TNF
36 11.1 IL1B IL6 TNF
37 11.1 GDNF IL1B IL6 MAPK1 TNF
38 11.07 MAPK1 TNF
39
Show member pathways
11.06 IL1B IL6 MAPK1 TNF
40 11.03 IL6 TNF
41 10.96 IL6 TNF
42 10.89 IL1B MAPK1 TNF
43 10.87 IL1B TNF

GO Terms for Acute Vascular Insufficiency of Intestine

Cellular components related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apicolateral plasma membrane GO:0016327 8.62 OCLN TJP1

Biological processes related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.96 CEP290 IL1B IL6 MAPK1 TNF
2 positive regulation of gene expression GO:0010628 9.93 IL1B IL6 MAPK1 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL1B IL6 TNF
4 MAPK cascade GO:0000165 9.8 GDNF IL1B MAPK1 TNF
5 activation of MAPK activity GO:0000187 9.78 IL1B MAPK1 TNF
6 response to ethanol GO:0045471 9.77 GOT2 IL1B TJP1
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.75 IL1B IL6 TNF
8 response to glucocorticoid GO:0051384 9.69 IL1B IL6 TNF
9 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL6 TNF
10 positive regulation of chemokine production GO:0032722 9.62 IL6 TNF
11 negative regulation of lipid catabolic process GO:0050995 9.62 IL1B TNF
12 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.61 IL1B TNF
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IL1B TNF
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
15 regulation of bicellular tight junction assembly GO:2000810 9.57 OCLN TJP1
16 negative regulation of lipid storage GO:0010888 9.55 IL6 TNF
17 positive regulation of chemokine biosynthetic process GO:0045080 9.54 IL1B TNF
18 regulation of establishment of endothelial barrier GO:1903140 9.52 IL1B TNF
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.5 GDNF IL1B TNF
20 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
21 chronic inflammatory response to antigenic stimulus GO:0002439 9.43 IL1B TNF
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 IL1B MAPK1 TNF
23 sequestering of triglyceride GO:0030730 9.4 IL1B TNF
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IL1B TNF
25 negative regulation of neurogenesis GO:0050768 9.33 IL1B IL6 TNF
26 positive regulation of glial cell proliferation GO:0060252 9.13 IL1B IL6 TNF
27 positive regulation of neuroinflammatory response GO:0150078 8.8 IL1B IL6 TNF

Sources for Acute Vascular Insufficiency of Intestine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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