Acute Vascular Insufficiency of Intestine disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Acute Vascular Insufficiency of Intestine

MalaCards integrated aliases for Acute Vascular Insufficiency of Intestine:

Name: Acute Vascular Insufficiency of Intestine ¹² ¹⁵ ⁷¹

Acute Gastrointestinal Tract Vascular Insuffic. ¹²

Acute Intestinal Vascular Insufficiency ¹²

Acute Git Vascular Insuffic. ¹²

Acute Intestinal Ischemia ¹²

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8590

ICD9CM ³⁴ 557.0

NCIt ⁴⁹ C34356

SNOMED-CT ⁶⁷ 91489000

UMLS ⁷¹ C0001363

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Summaries for Acute Vascular Insufficiency of Intestine

MalaCards based summary : Acute Vascular Insufficiency of Intestine, also known as acute gastrointestinal tract vascular insuffic., is related to ischemia and thrombophilia due to thrombin defect. An important gene associated with Acute Vascular Insufficiency of Intestine is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are PPAR signaling pathway and Tyrosine metabolism.

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Related Diseases for Acute Vascular Insufficiency of Intestine

Diseases related to Acute Vascular Insufficiency of Intestine via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)

#	Related Disease	Score	Top Affiliating Genes
1	ischemia	10.7
2	thrombophilia due to thrombin defect	10.1
3	peritonitis	10.1
4	multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	10.0
5	thrombosis	10.0
6	gastrointestinal system disease	9.9
7	cardiac arrhythmia	9.8
8	ocular motor apraxia	9.8
9	encephalopathy, progressive, early-onset, with episodic rhabdomyolysis	9.8
10	metabolic acidosis	9.8
11	covid-19	9.8
12	endocarditis	9.8
13	short bowel syndrome	9.8
14	mesenteric vascular occlusion	9.8
15	toxic shock syndrome	9.8
16	neuroendocrine tumor	9.8
17	congestive heart failure	9.8
18	appendicitis	9.8
19	intestinal obstruction	9.8
20	spinal cord injury	9.8
21	jejunal neuroendocrine tumor	9.8
22	intracranial embolism	9.8	SERPINC1 OCLN
23	liver benign neoplasm	9.7	HPGDS GOT2
24	perinatal necrotizing enterocolitis	9.6	OCLN GOT2 FABP2
25	celiac disease 1	9.4	OCLN GOT2 FABP2

Comorbidity relations with Acute Vascular Insufficiency of Intestine via Phenotypic Disease Network (PDN): (show all 19)

Active Peptic Ulcer Disease	Acute Cystitis
Acute Kidney Failure	Acute Pancreatitis
Aortic Aneurysm	Chronic Intestinal Vascular Insufficiency
Decubitus Ulcer	Deficiency Anemia
Familial Atrial Fibrillation	Heart Disease
Hypertension, Essential	Intestinal Obstruction
Intestinal Perforation	Paralytic Ileus
Peripheral Vascular Disease	Peritonitis
Portal Vein Thrombosis	Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Acute Vascular Insufficiency of Intestine:

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Symptoms & Phenotypes for Acute Vascular Insufficiency of Intestine

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Drugs & Therapeutics for Acute Vascular Insufficiency of Intestine

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Preoperative Findings on Non-specific CT in Patients With Primary Acute Intestinal Ischaemia; a Case-control Study	Completed	NCT04361110
2	Searching Biomarkers of Acute Intestinal Ischemic Injuries	Recruiting	NCT03518099

Search NIH Clinical Center for Acute Vascular Insufficiency of Intestine

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Genetic Tests for Acute Vascular Insufficiency of Intestine

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Anatomical Context for Acute Vascular Insufficiency of Intestine

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Publications for Acute Vascular Insufficiency of Intestine

Articles related to Acute Vascular Insufficiency of Intestine:

#	Title	Authors	PMID	Year
1	Acute vascular insufficiency of intestine: incidence highest in summer, outcomes worst in winter. ⁶¹	Jehangir A...York EP	31707559	2019
2	Ischemic colitis related to cocaine abuse. ⁶¹	Brown DN...Marshall JB	8079939	1994
3	[Acute intestinal vascular insufficiency. Clinical-surgical study]. ⁶¹	Goffi FS...de Godoy AC	5311669	1970

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Genes for Acute Vascular Insufficiency of Intestine

Genes related to Acute Vascular Insufficiency of Intestine (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FABP2	Fatty Acid Binding Protein 2	Protein Coding	7.38	DISEASES inferred ¹⁵
2	GOT2	Glutamic-Oxaloacetic Transaminase 2	Protein Coding	6.72	DISEASES inferred ¹⁵
3	SERPINC1	Serpin Family C Member 1	Protein Coding	5.16	DISEASES inferred ¹⁵
4	AOC1	Amine Oxidase Copper Containing 1	Protein Coding	5.09	DISEASES inferred ¹⁵
5	DEFA6	Defensin Alpha 6	Protein Coding	4.94	DISEASES inferred ¹⁵
6	OCLN	Occludin	Protein Coding	4.88	DISEASES inferred ¹⁵
7	FABP6	Fatty Acid Binding Protein 6	Protein Coding	4.87	DISEASES inferred ¹⁵
8	OSMR	Oncostatin M Receptor	Protein Coding	4.85	DISEASES inferred ¹⁵
9	HPGDS	Hematopoietic Prostaglandin D Synthase	Protein Coding	4.76	DISEASES inferred ¹⁵

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Variations for Acute Vascular Insufficiency of Intestine

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Expression for Acute Vascular Insufficiency of Intestine

Search GEO for disease gene expression data for Acute Vascular Insufficiency of Intestine.

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Pathways for Acute Vascular Insufficiency of Intestine

Pathways related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PPAR signaling pathway ³⁶	11.14	FABP6 FABP2
2	Tyrosine metabolism ³⁶ Show member pathways Phenylalanine metabolism ³⁶ Phenylalanine, tyrosine and tryptophan biosynthesis ³⁶ Tyrosine metabolism p.1 (dopamine) ²²	11.04	GOT2 AOC1
3	Arginine and proline metabolism ³⁶ Show member pathways 4-hydroxyproline degradation ¹ Agmatine biosynthesis ⁶⁵ putrescine biosynthesis II ¹	10.71	GOT2 AOC1
4	Fat digestion and absorption ³⁶ Show member pathways Trafficking of dietary sterols ⁶⁵	10.29	GOT2 FABP2

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GO Terms for Acute Vascular Insufficiency of Intestine

Biological processes related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lactation	GO:0007595	8.96	SERPINC1 GOT2
2	triglyceride catabolic process	GO:0019433	8.62	FABP6 FABP2

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