MCID: ADM013
MIFTS: 30

Adamantinoma of Long Bones

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Adamantinoma of Long Bones

MalaCards integrated aliases for Adamantinoma of Long Bones:

Name: Adamantinoma of Long Bones 56 58 43
Long Bone Adamantinoma 12 15

Characteristics:

Orphanet epidemiological data:

58
adamantinoma of long bones
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Worldwide); Age of onset: Adolescent,Adult,Childhood; Age of death: normal life expectancy;

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
adamantinoma of long bones:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Rare bone diseases


External Ids:

Disease Ontology 12 DOID:2775
OMIM 56 102660
MeSH 43 C562741
SNOMED-CT 67 56763007
MESH via Orphanet 44 D050398
ICD10 via Orphanet 33 C40.2
UMLS via Orphanet 72 C1367554
Orphanet 58 ORPHA55881
MedGen 41 C0334556
SNOMED-CT via HPO 68 108369006 263681008 363346000
UMLS 71 C0334556

Summaries for Adamantinoma of Long Bones

Disease Ontology : 12 An adamantinoma that is located in the long bones and results in focal epithelial differentiation.

MalaCards based summary : Adamantinoma of Long Bones, also known as long bone adamantinoma, is related to tibial adamantinoma and biphasic synovial sarcoma. An important gene associated with Adamantinoma of Long Bones is EGF (Epidermal Growth Factor), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Lung fibrosis. Affiliated tissues include long bones, bone and eye, and related phenotypes are neoplasm and pathologic fracture

More information from OMIM: 102660

Related Diseases for Adamantinoma of Long Bones

Graphical network of the top 20 diseases related to Adamantinoma of Long Bones:



Diseases related to Adamantinoma of Long Bones

Symptoms & Phenotypes for Adamantinoma of Long Bones

Human phenotypes related to Adamantinoma of Long Bones:

31 58
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neoplasm 31 HP:0002664
2 pathologic fracture 58 Occasional (29-5%)
3 hypercalcemia 58 Occasional (29-5%)
4 bone pain 58 Frequent (79-30%)

Symptoms via clinical synopsis from OMIM:

56
Oncology:
adamantinoma of long bones

Clinical features from OMIM:

102660

Drugs & Therapeutics for Adamantinoma of Long Bones

Search Clinical Trials , NIH Clinical Center for Adamantinoma of Long Bones

Cochrane evidence based reviews: adamantinoma of long bones

Genetic Tests for Adamantinoma of Long Bones

Anatomical Context for Adamantinoma of Long Bones

The Foundational Model of Anatomy Ontology organs/tissues related to Adamantinoma of Long Bones:

19
Long Bones

MalaCards organs/tissues related to Adamantinoma of Long Bones:

40
Bone, Eye, Testes, Colon, Breast, Skin

Publications for Adamantinoma of Long Bones

Articles related to Adamantinoma of Long Bones:

(show all 39)
# Title Authors PMID Year
1
Adamantinoma of long bones. A clinicopathologic study of 85 cases. 61 56
2743266 1989
2
Involvement of the region 13q14 in a patient with adamantinoma of the long bones. 56
2227936 1990
3
Primary lesions that may imitate metastatic tumors histologically: A selective review. 61
29174934 2018
4
Adamantinoma of tibia in Ethiopia: the first bone transplant in Ethiopia. 61
22924287 2012
5
Fibro-Osseous Lesions. 61
26837922 2012
6
Mesenchymal-epithelial differentiation of adamantinoma of long bones: an immunohistochemical and ultrastructural study. 61
22292734 2012
7
Analysis of stromal cells in osteofibrous dysplasia and adamantinoma of long bones. 61
21983933 2012
8
Podoplanin expression in adamantinoma of long bones and osteofibrous dysplasia. 61
21499851 2011
9
Adamantinoma of long bones: a long-term follow-up study of 11 cases. 61
19048403 2009
10
[A rare case of pneumothorax: metastatic adamantinoma]. 61
18622511 2008
11
Adamantinoma of tibia: a study of 12 cases. 61
16550582 2006
12
MRI of adamantinoma of long bones in correlation with histopathology. 61
15547221 2004
13
Dedifferentiated adamantinoma with revertant mesenchymal phenotype. 61
14657712 2003
14
Osteofibrous dysplasia: a review of the literature and presentation of an additional 3 cases. 61
14620087 2003
15
[Adamantinoma of the long bones: an anatomo-clinical review and its relationship with osteofibrous dysplasia]. 61
11910937 2001
16
Extra copies of chromosomes 7, 8, 12, 19, and 21 are recurrent in adamantinoma. 61
11227067 2001
17
Current trends in the management of adamantinoma of long bones. An international study. 61
10954102 2000
18
Expression of growth factors and their receptors in adamantinoma of long bones and the implication for its histogenesis. 61
9582523 1998
19
Cytogenetic analysis of adamantinoma of long bones: further indications for a common histogenesis with osteofibrous dysplasia. 61
9242211 1997
20
Distribution of extracellular matrix components in adamantinoma of long bones suggests fibrous-to-epithelial transformation. 61
9023400 1997
21
Disseminating adamantinoma of the tibia. 61
18521211 1997
22
DNA aberrations in the epithelial cell component of adamantinoma of long bones. 61
7495301 1995
23
Adamantinoma of long bones. A histopathological and immunohistochemical study of 23 cases. 61
7567680 1995
24
Test and teach. Number seventy-nine. Diagnosis: Adamantinoma of long bones. 61
7892039 1994
25
A clinicopathological and immunohistochemical study of osteofibrous dysplasia, differentiated adamantinoma, and adamantinoma of long bones. 61
1281557 1992
26
Morphologic diversity of long bone adamantinoma. The concept of differentiated (regressing) adamantinoma and its relationship to osteofibrous dysplasia. 61
2804923 1989
27
Fine-needle aspiration biopsy of tibial adamantinoma: a case report. 61
2454180 1988
28
Unusual localization of adamantinoma of long bones. Report of a case of isolated fibular involvement. 61
3944167 1986
29
Haemangiosarcoma of bone. 61
4040502 1985
30
Adamantinoma of long bones. 61
6493828 1984
31
Adamantinoma of long bones: clinical, pathological and ultrastructural features. 61
7201477 1982
32
An unusual case of adamantinoma of long bones. 61
7161313 1982
33
Ultrastructure of adamantinoma of long bones. 61
6270877 1981
34
[Adamantinoma of long bones (author's transl)]. 61
7214584 1981
35
[Differential diagnosis of a metastasizing adamantinoma of the tibia and fibula (author's transl)]. 61
475564 1979
36
Ossifying fibroma of long bone: its distinction from fibrous dysplasia and its association with adamantinoma of long bone. 61
413432 1978
37
[A so-called adamantinoma of the right femur (author's transl)]. 61
189527 1976
38
Adamantinoma of long bones. A clinicopathological study of fourteen cases with vascular origin suggested. 61
1112840 1975
39
SO-CALLED ADAMANTINOMA OF LONG BONES. 61
14104305 1964

Variations for Adamantinoma of Long Bones

Expression for Adamantinoma of Long Bones

Search GEO for disease gene expression data for Adamantinoma of Long Bones.

Pathways for Adamantinoma of Long Bones

Pathways related to Adamantinoma of Long Bones according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.15 FGF2 EGF
2 10.96 FGF2 EGF
3 10.64 FGF2 EGF
4 10.26 FGF2 EGF

GO Terms for Adamantinoma of Long Bones

Biological processes related to Adamantinoma of Long Bones according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAP kinase activity GO:0043406 8.62 FGF2 EGF

Sources for Adamantinoma of Long Bones

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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