MCID: ADM001
MIFTS: 31

Adamantinous Craniopharyngioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Adamantinous Craniopharyngioma

MalaCards integrated aliases for Adamantinous Craniopharyngioma:

Name: Adamantinous Craniopharyngioma 12 15 72
Craniopharyngioma, Adamantinomatous 12
Adamantinomatous Craniopharyngioma 17
Adamantinous Rathke's Pouch Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3846
MeSH 44 D003397
NCIt 50 C4726
UMLS 72 C0431129

Summaries for Adamantinous Craniopharyngioma

MalaCards based summary : Adamantinous Craniopharyngioma, also known as craniopharyngioma, adamantinomatous, is related to pituitary tumors and papillary craniopharyngioma, and has symptoms including visual disturbance An important gene associated with Adamantinous Craniopharyngioma is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are G-Beta Gamma Signaling and Pathways in cancer. Affiliated tissues include endothelial, and related phenotypes are Increased Nanog expression and Increased Nanog expression

Related Diseases for Adamantinous Craniopharyngioma

Diseases related to Adamantinous Craniopharyngioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 pituitary tumors 30.7 VEGFA PROP1
2 papillary craniopharyngioma 30.1 DNAH7 DNAH2 DNAH12 CTNNB1
3 angiokeratoma circumscriptum 10.5 VEGFA MMP9
4 sick building syndrome 10.5 VEGFA MMP9
5 ischemic colitis 10.5 VEGFA MMP9
6 psammomatous meningioma 10.5 MMP9 CTNNB1
7 odontogenic myxoma 10.5 VEGFA MMP9
8 ameloblastoma 10.4
9 tuberculous meningitis 10.4 VEGFA MMP9
10 rosacea 10.4 VEGFA MMP9
11 adenoma 10.4
12 arteriovenous malformation 10.3 VEGFA MMP9
13 craniopharyngioma 10.3
14 keratocystic odontogenic tumor 10.2 SHH MMP9
15 nasopharyngeal disease 10.2 VEGFA MMP9 CTNNB1
16 central nervous system tuberculosis 10.2 SHH MMP9
17 pharynx cancer 10.2 VEGFA MMP9 CTNNB1
18 breast cancer 10.2
19 colorectal cancer 10.2
20 meningioma, radiation-induced 10.2
21 familial adenomatous polyposis 10.2
22 hemangioma 10.2
23 astrocytoma 10.2
24 pituitary adenoma 10.2
25 pituitary gland disease 10.2
26 pilocytic astrocytoma 10.2
27 male reproductive organ cancer 10.2 VEGFA MMP9 CTNNB1
28 stomach disease 10.2 VEGFA MMP9 CTNNB1
29 female reproductive system disease 10.2 VEGFA MMP9 CTNNB1
30 reproductive system disease 10.2 VEGFA MMP9 CTNNB1
31 respiratory system cancer 10.2 VEGFA MMP9 CTNNB1
32 gastrointestinal system cancer 10.2 VEGFA MMP9 CTNNB1
33 endocrine gland cancer 10.2 VEGFA MMP9 CTNNB1
34 gastrointestinal system disease 10.2 VEGFA MMP9 CTNNB1
35 adamantinoma of long bones 10.1 VEGFA MMP9 CTNNB1
36 infratentorial cancer 10.1 SHH CTNNB1
37 squamous cell carcinoma, head and neck 10.0 VEGFA MMP9 CTNNB1
38 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.0 PROP1 HESX1
39 combined pituitary hormone deficiencies, genetic forms 10.0 PROP1 HESX1
40 septooptic dysplasia 10.0 PROP1 HESX1
41 combined pituitary hormone deficiency 10.0 PROP1 HESX1
42 pituitary stalk interruption syndrome 9.9 SHH HESX1
43 large intestine cancer 9.9 VEGFA MMP9 CTNNB1
44 axenfeld-rieger syndrome, type 1 9.9 SHH HESX1
45 schizencephaly 9.8 SHH HESX1
46 pituitary hormone deficiency, combined, 2 9.7 PROP1 HESX1
47 isolated growth hormone deficiency 9.7 PROP1 HESX1
48 borjeson-forssman-lehmann syndrome 9.6 PROP1 HESX1
49 brain cancer 9.3 VEGFA SHH CTNNB1

Graphical network of the top 20 diseases related to Adamantinous Craniopharyngioma:



Diseases related to Adamantinous Craniopharyngioma

Symptoms & Phenotypes for Adamantinous Craniopharyngioma

UMLS symptoms related to Adamantinous Craniopharyngioma:


visual disturbance

GenomeRNAi Phenotypes related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.28 MMP9 PROP1 VEGFA
2 Increased Nanog expression GR00371-A-2 9.28 VEGFA
3 Increased Nanog expression GR00371-A-3 9.28 PROP1
4 Increased Nanog expression GR00371-A-4 9.28 VEGFA
5 Increased Nanog expression GR00371-A-5 9.28 MMP9 PROP1 VEGFA

MGI Mouse Phenotypes related to Adamantinous Craniopharyngioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.43 CTNNB1 HESX1 MMP9 PROP1 SHH VEGFA
2 taste/olfaction MP:0005394 8.8 CTNNB1 HESX1 SHH

Drugs & Therapeutics for Adamantinous Craniopharyngioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 0/Feasibility Trial of Tocilizumab in Children and Adolescents With Newly‐ Diagnosed or Recurrent/Progressive Adamantinomatous Craniopharyngioma Recruiting NCT03970226 Early Phase 1 Tocilizumab
2 Advancing Treatment for Pediatric Craniopharyngioma: Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy Recruiting NCT03610906

Search NIH Clinical Center for Adamantinous Craniopharyngioma

Genetic Tests for Adamantinous Craniopharyngioma

Anatomical Context for Adamantinous Craniopharyngioma

MalaCards organs/tissues related to Adamantinous Craniopharyngioma:

41
Endothelial

Publications for Adamantinous Craniopharyngioma

Articles related to Adamantinous Craniopharyngioma:

(show all 11)
# Title Authors PMID Year
1
Noninvasive molecular diagnosis of craniopharyngioma with MRI-based radiomics approach. 38
30616515 2019
2
Craniopharyngioma: a roadmap for scientific translation. 38
29852761 2018
3
12 Years delayed postoperative spinal recurrence of craniopharyngioma. Case report and literature review. 38
29199465 2017
4
Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies. 38
23560577 2013
5
Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. 38
22349813 2012
6
Infrasellar craniopharyngioma of the posterior nasal septum: a rare entity. 38
22582569 2012
7
Expression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngioma. 38
21814723 2011
8
Ectopic recurrence of a craniopharyngioma in a 15-year-old girl 9 years after surgery and conventional radiotherapy: case report. 38
21221975 2011
9
Glare in a Case of a Craniopharyngioma. 38
30151024 2011
10
MR differentiation of adamantinous and squamous-papillary craniopharyngiomas. 38
9010523 1997
11
Ossified adamantinous type craniopharyngiomas. A series of 13 patients. 38
7942198 1994

Variations for Adamantinous Craniopharyngioma

Expression for Adamantinous Craniopharyngioma

Search GEO for disease gene expression data for Adamantinous Craniopharyngioma.

Pathways for Adamantinous Craniopharyngioma

GO Terms for Adamantinous Craniopharyngioma

Cellular components related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.65 TUBA4A DNAH7 DNAH2 DNAH12 CTNNB1
2 microtubule GO:0005874 9.26 TUBA4A DNAH7 DNAH2 DNAH12
3 axonemal dynein complex GO:0005858 9.16 DNAH7 DNAH2
4 dynein complex GO:0030286 8.8 DNAH7 DNAH2 DNAH12

Biological processes related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.84 VEGFA SHH CTNNB1
2 negative regulation of apoptotic process GO:0043066 9.83 VEGFA SHH PROP1 MMP9 CTNNB1
3 kidney development GO:0001822 9.73 VEGFA SHH CTNNB1
4 lung development GO:0030324 9.72 VEGFA SHH CTNNB1
5 positive regulation of cell division GO:0051781 9.68 VEGFA SHH
6 thymus development GO:0048538 9.68 SHH CTNNB1
7 skin development GO:0043588 9.68 SHH CTNNB1
8 branching involved in ureteric bud morphogenesis GO:0001658 9.67 SHH CTNNB1
9 limb development GO:0060173 9.67 SHH CTNNB1
10 microtubule-based movement GO:0007018 9.67 DNAH7 DNAH2 DNAH12
11 midbrain development GO:0030901 9.66 SHH CTNNB1
12 cell maturation GO:0048469 9.66 VEGFA CTNNB1
13 embryonic forelimb morphogenesis GO:0035115 9.65 SHH CTNNB1
14 T cell differentiation in thymus GO:0033077 9.65 SHH CTNNB1
15 pancreas development GO:0031016 9.65 SHH CTNNB1
16 canonical Wnt signaling pathway GO:0060070 9.65 SHH PROP1 CTNNB1
17 embryonic hindlimb morphogenesis GO:0035116 9.64 SHH CTNNB1
18 branching morphogenesis of an epithelial tube GO:0048754 9.64 VEGFA SHH
19 vasculature development GO:0001944 9.63 SHH CTNNB1
20 hair follicle morphogenesis GO:0031069 9.63 SHH CTNNB1
21 vasculogenesis GO:0001570 9.63 VEGFA SHH CTNNB1
22 dopaminergic neuron differentiation GO:0071542 9.62 VEGFA SHH
23 hindbrain development GO:0030902 9.61 SHH CTNNB1
24 male genitalia development GO:0030539 9.61 SHH CTNNB1
25 cell fate specification GO:0001708 9.6 SHH CTNNB1
26 cilium-dependent cell motility GO:0060285 9.59 DNAH7 DNAH2
27 macrophage differentiation GO:0030225 9.58 VEGFA MMP9
28 epithelial tube branching involved in lung morphogenesis GO:0060441 9.58 SHH CTNNB1
29 ectoderm development GO:0007398 9.57 SHH CTNNB1
30 positive regulation of skeletal muscle tissue development GO:0048643 9.54 SHH CTNNB1
31 embryonic foregut morphogenesis GO:0048617 9.52 SHH CTNNB1
32 lung-associated mesenchyme development GO:0060484 9.51 SHH CTNNB1
33 dorsal/ventral pattern formation GO:0009953 9.43 SHH PROP1 CTNNB1
34 trachea morphogenesis GO:0060439 9.4 SHH CTNNB1
35 positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 9.37 SHH CTNNB1
36 branching involved in blood vessel morphogenesis GO:0001569 9.33 VEGFA SHH CTNNB1
37 renal system development GO:0072001 9.32 SHH
38 mesenchymal cell proliferation involved in lung development GO:0060916 9.32 SHH CTNNB1
39 positive regulation of mesenchymal cell proliferation GO:0002053 9.13 VEGFA SHH CTNNB1
40 positive regulation of neuroblast proliferation GO:0002052 8.8 VEGFA SHH CTNNB1

Molecular functions related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein C-terminus binding GO:0008022 9.5 PROP1 HESX1 CTNNB1
2 dynein light intermediate chain binding GO:0051959 9.4 DNAH7 DNAH2
3 dynein intermediate chain binding GO:0045505 9.37 DNAH7 DNAH2
4 dynein light chain binding GO:0045503 9.26 DNAH7 DNAH2
5 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 9.16 DNAH7 DNAH2
6 motor activity GO:0003774 9.13 DNAH7 DNAH2 DNAH12
7 microtubule motor activity GO:0003777 8.8 DNAH7 DNAH2 DNAH12

Sources for Adamantinous Craniopharyngioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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