MCID: ADM001
MIFTS: 28

Adamantinous Craniopharyngioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Adamantinous Craniopharyngioma

MalaCards integrated aliases for Adamantinous Craniopharyngioma:

Name: Adamantinous Craniopharyngioma 12 15 73
Craniopharyngioma, Adamantinomatous 12
Adamantinous Rathke's Pouch Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3846
MeSH 44 D003397
NCIt 50 C4726
UMLS 73 C0431129

Summaries for Adamantinous Craniopharyngioma

MalaCards based summary : Adamantinous Craniopharyngioma, also known as craniopharyngioma, adamantinomatous, is related to craniopharyngioma and angiokeratoma circumscriptum, and has symptoms including visual disturbance An important gene associated with Adamantinous Craniopharyngioma is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are G-Beta Gamma Signaling and Proteoglycans in cancer. Affiliated tissues include lung, brain and bone.

Related Diseases for Adamantinous Craniopharyngioma

Diseases related to Adamantinous Craniopharyngioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 craniopharyngioma 10.2
2 angiokeratoma circumscriptum 10.2 MMP9 VEGFA
3 sick building syndrome 10.2 MMP9 VEGFA
4 ischemic colitis 10.2 MMP9 VEGFA
5 odontogenic myxoma 10.2 MMP9 VEGFA
6 tuberculous meningitis 10.2 MMP9 VEGFA
7 rosacea 10.2 MMP9 VEGFA
8 arteriovenous malformation 10.2 MMP9 VEGFA
9 cystadenoma 10.2
10 adenomyosis 10.1 MMP9 VEGFA
11 psammomatous meningioma 10.1 CTNNB1 MMP9
12 keratitis, hereditary 10.1 MMP9 VEGFA
13 severe pre-eclampsia 10.1 MMP9 VEGFA
14 cervix disease 10.1 CTNNB1 VEGFA
15 grade iii astrocytoma 10.1 MMP9 VEGFA
16 exudative vitreoretinopathy 1 10.0 CTNNB1 VEGFA
17 varicose veins 10.0 MMP9 VEGFA
18 uterine anomalies 10.0 CTNNB1 VEGFA
19 nasopharyngeal disease 10.0 CTNNB1 MMP9 VEGFA
20 pharynx cancer 10.0 CTNNB1 MMP9 VEGFA
21 male reproductive organ cancer 10.0 CTNNB1 MMP9 VEGFA
22 stomach disease 10.0 CTNNB1 MMP9 VEGFA
23 female reproductive system disease 10.0 CTNNB1 MMP9 VEGFA
24 reproductive system disease 10.0 CTNNB1 MMP9 VEGFA
25 respiratory system cancer 10.0 CTNNB1 MMP9 VEGFA
26 gastrointestinal system cancer 10.0 CTNNB1 MMP9 VEGFA
27 endocrine gland cancer 10.0 CTNNB1 MMP9 VEGFA
28 gastrointestinal system disease 10.0 CTNNB1 MMP9 VEGFA
29 pancreas adenocarcinoma 10.0 CTNNB1 MMP9 VEGFA
30 adamantinoma of long bones 10.0 CTNNB1 MMP9 VEGFA
31 squamous cell carcinoma, head and neck 10.0 CTNNB1 MMP9 VEGFA
32 large intestine cancer 10.0 CTNNB1 MMP9 VEGFA
33 nasopharyngeal carcinoma 10.0 CTNNB1 MMP9 VEGFA
34 colonic disease 10.0 CTNNB1 VEGFA
35 gastric adenocarcinoma 9.9 CTNNB1 MMP9 VEGFA
36 lung cancer susceptibility 3 9.9 CTNNB1 MMP9 VEGFA
37 tongue cancer 9.9 CTNNB1 MMP9
38 papillary craniopharyngioma 9.8 CTNNB1 DNAH12 DNAH2 DNAH7

Graphical network of the top 20 diseases related to Adamantinous Craniopharyngioma:



Diseases related to Adamantinous Craniopharyngioma

Symptoms & Phenotypes for Adamantinous Craniopharyngioma

UMLS symptoms related to Adamantinous Craniopharyngioma:


visual disturbance

Drugs & Therapeutics for Adamantinous Craniopharyngioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy Recruiting NCT03610906

Search NIH Clinical Center for Adamantinous Craniopharyngioma

Genetic Tests for Adamantinous Craniopharyngioma

Anatomical Context for Adamantinous Craniopharyngioma

MalaCards organs/tissues related to Adamantinous Craniopharyngioma:

41
Lung, Brain, Bone, Colon, Tongue, Pancreas, Cervix

Publications for Adamantinous Craniopharyngioma

Articles related to Adamantinous Craniopharyngioma:

# Title Authors Year
1
Expression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngioma. ( 21814723 )
2011

Variations for Adamantinous Craniopharyngioma

Expression for Adamantinous Craniopharyngioma

Search GEO for disease gene expression data for Adamantinous Craniopharyngioma.

Pathways for Adamantinous Craniopharyngioma

GO Terms for Adamantinous Craniopharyngioma

Cellular components related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.72 CTNNB1 DNAH12 DNAH2 DNAH7 TUBA4A
2 cell projection GO:0042995 9.67 CTNNB1 DNAH12 DNAH2 DNAH7
3 cilium GO:0005929 9.58 DNAH12 DNAH2 DNAH7
4 presynaptic active zone cytoplasmic component GO:0098831 9.26 CTNNB1 RIMS1
5 microtubule GO:0005874 9.26 DNAH12 DNAH2 DNAH7 TUBA4A
6 axonemal dynein complex GO:0005858 9.16 DNAH2 DNAH7
7 dynein complex GO:0030286 8.8 DNAH12 DNAH2 DNAH7

Biological processes related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vasculogenesis GO:0001570 9.43 CTNNB1 VEGFA
2 cell maturation GO:0048469 9.4 CTNNB1 VEGFA
3 branching involved in blood vessel morphogenesis GO:0001569 9.37 CTNNB1 VEGFA
4 positive regulation of mesenchymal cell proliferation GO:0002053 9.32 CTNNB1 VEGFA
5 positive regulation of neuroblast proliferation GO:0002052 9.26 CTNNB1 VEGFA
6 cilium-dependent cell motility GO:0060285 9.16 DNAH2 DNAH7
7 macrophage differentiation GO:0030225 8.96 MMP9 VEGFA
8 microtubule-based movement GO:0007018 8.8 DNAH12 DNAH2 DNAH7

Molecular functions related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dynein intermediate chain binding GO:0045505 9.37 DNAH2 DNAH7
2 dynein light intermediate chain binding GO:0051959 9.32 DNAH2 DNAH7
3 dynein light chain binding GO:0045503 9.26 DNAH2 DNAH7
4 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 9.16 DNAH2 DNAH7
5 motor activity GO:0003774 9.13 DNAH12 DNAH2 DNAH7
6 microtubule motor activity GO:0003777 8.8 DNAH12 DNAH2 DNAH7

Sources for Adamantinous Craniopharyngioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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