MCID: ADM001
MIFTS: 32

Adamantinous Craniopharyngioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Adamantinous Craniopharyngioma

MalaCards integrated aliases for Adamantinous Craniopharyngioma:

Name: Adamantinous Craniopharyngioma 12 15 71
Craniopharyngioma, Adamantinomatous 12
Adamantinomatous Craniopharyngioma 17
Adamantinous Rathke's Pouch Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3846
MeSH 43 D003397
NCIt 49 C4726
UMLS 71 C0431129

Summaries for Adamantinous Craniopharyngioma

MalaCards based summary : Adamantinous Craniopharyngioma, also known as craniopharyngioma, adamantinomatous, is related to ameloblastoma and papillary craniopharyngioma, and has symptoms including visual disturbance An important gene associated with Adamantinous Craniopharyngioma is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include pituitary, tongue and breast, and related phenotypes are craniofacial and limbs/digits/tail

Related Diseases for Adamantinous Craniopharyngioma

Diseases related to Adamantinous Craniopharyngioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 ameloblastoma 30.4 MMP9 MMP20 ENAM
2 papillary craniopharyngioma 29.4 NDUFAB1 MMP20 ENAM DNAH2 CTNNB1 AASDHPPT
3 craniopharyngioma 29.2 VEGFA MMP9 MMP20 LEF1 ENAM CTNNB1
4 odontogenic myxoma 10.4 VEGFA MMP9
5 angiokeratoma circumscriptum 10.4 VEGFA MMP9
6 brain stem medulloblastoma 10.4 SHH CTNNB1
7 sick building syndrome 10.4 VEGFA MMP9
8 adenoma 10.4
9 pituitary tumors 10.4
10 tuberculous meningitis 10.3 VEGFA MMP9
11 isolated growth hormone deficiency type iii 10.3 HESX1 ESX1
12 nodular medulloblastoma 10.3 SHH CTNNB1
13 gastroesophageal junction adenocarcinoma 10.3 VEGFA MMP9
14 macular dystrophy, patterned, 2 10.3 HESX1 ESX1
15 keratocystic odontogenic tumor 10.3 SHH MMP9
16 macular dystrophy, patterned, 1 10.3 HESX1 ESX1
17 bone squamous cell carcinoma 10.3 MMP9 CTNNB1
18 adenomyosis 10.3 VEGFA MMP9 CTNNB1
19 tongue disease 10.3 VEGFA MMP9 CTNNB1
20 colorectal adenoma 10.2 VEGFA MMP9 CTNNB1
21 tongue cancer 10.2 VEGFA MMP9 CTNNB1
22 malignant ovarian surface epithelial-stromal neoplasm 10.2 VEGFA MMP9 CTNNB1
23 retinal detachment 10.2 VEGFA MMP9 CTNNB1
24 colorectal adenocarcinoma 10.2 VEGFA MMP9 CTNNB1
25 breast cancer 10.2
26 colorectal cancer 10.2
27 meningioma, radiation-induced 10.2
28 familial adenomatous polyposis 10.2
29 hemangioma 10.2
30 astrocytoma 10.2
31 pituitary adenoma 10.2
32 pituitary gland disease 10.2
33 juvenile pilocytic astrocytoma 10.2
34 growth hormone deficiency 10.2
35 hair follicle neoplasm 10.2 LEF1 CTNNB1
36 congenital hypopituitarism 10.1 SHH HESX1
37 decubitus ulcer 10.1 VEGFA TMSB4X MMP9
38 septooptic dysplasia 10.1 SHH HESX1 ESX1
39 pituitary stalk interruption syndrome 10.1 SHH HESX1
40 breast ductal carcinoma 10.0 VEGFA MMP9 CTNNB1
41 hypocalcified amelogenesis imperfecta 10.0 MMP20 ENAM
42 amelogenesis imperfecta, type ic 10.0 MMP20 ENAM
43 enamel caries 10.0 MMP20 ENAM
44 tongue squamous cell carcinoma 10.0 VEGFA MMP9 CTNNB1
45 hypercementosis 9.9 MMP20 ENAM
46 amelogenesis imperfecta, type ib 9.9 MMP20 ENAM
47 dental fluorosis 9.8 MMP9 MMP20 ENAM
48 intestinal benign neoplasm 9.8 VEGFA CTNNB1 AXIN2
49 amelogenesis imperfecta, type iiia 9.6 MMP20 ENAM
50 coloboma of macula 9.6 SHH HESX1 ESX1

Graphical network of the top 20 diseases related to Adamantinous Craniopharyngioma:



Diseases related to Adamantinous Craniopharyngioma

Symptoms & Phenotypes for Adamantinous Craniopharyngioma

UMLS symptoms related to Adamantinous Craniopharyngioma:


visual disturbance

MGI Mouse Phenotypes related to Adamantinous Craniopharyngioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.76 AXIN2 CTNNB1 ENAM HESX1 LEF1 MMP20
2 limbs/digits/tail MP:0005371 9.5 ASCC2 AXIN2 CTNNB1 LEF1 MMP9 SHH
3 vision/eye MP:0005391 9.23 ASCC2 AXIN2 CTNNB1 HESX1 LEF1 MMP9

Drugs & Therapeutics for Adamantinous Craniopharyngioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 0/Feasibility Trial of Tocilizumab in Children and Adolescents With Newly‐ Diagnosed or Recurrent/Progressive Adamantinomatous Craniopharyngioma Recruiting NCT03970226 Early Phase 1 Tocilizumab
2 Advancing Treatment for Pediatric Craniopharyngioma: Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy Recruiting NCT03610906

Search NIH Clinical Center for Adamantinous Craniopharyngioma

Genetic Tests for Adamantinous Craniopharyngioma

Anatomical Context for Adamantinous Craniopharyngioma

MalaCards organs/tissues related to Adamantinous Craniopharyngioma:

40
Pituitary, Tongue, Breast, Endothelial, Bone, Brain

Publications for Adamantinous Craniopharyngioma

Articles related to Adamantinous Craniopharyngioma:

(show all 11)
# Title Authors PMID Year
1
12 Years delayed postoperative spinal recurrence of craniopharyngioma. Case report and literature review. 61
29199465 2019
2
Noninvasive molecular diagnosis of craniopharyngioma with MRI-based radiomics approach. 61
30616515 2019
3
Craniopharyngioma: a roadmap for scientific translation. 61
29852761 2018
4
Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies. 61
23560577 2013
5
Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. 61
22349813 2012
6
Infrasellar craniopharyngioma of the posterior nasal septum: a rare entity. 61
22582569 2012
7
Expression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngioma. 61
21814723 2011
8
Ectopic recurrence of a craniopharyngioma in a 15-year-old girl 9 years after surgery and conventional radiotherapy: case report. 61
21221975 2011
9
Glare in a Case of a Craniopharyngioma. 61
30151024 2011
10
MR differentiation of adamantinous and squamous-papillary craniopharyngiomas. 61
9010523 1997
11
Ossified adamantinous type craniopharyngiomas. A series of 13 patients. 61
7942198 1994

Variations for Adamantinous Craniopharyngioma

Expression for Adamantinous Craniopharyngioma

Search GEO for disease gene expression data for Adamantinous Craniopharyngioma.

Pathways for Adamantinous Craniopharyngioma

Pathways related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 VEGFA MMP9 LEF1 CTNNB1 AXIN2
2 12.46 VEGFA SHH MMP9 LEF1 CTNNB1 AXIN2
3
Show member pathways
12.44 VEGFA MMP9 LEF1 CTNNB1
4
Show member pathways
12.32 SHH LEF1 CTNNB1 AXIN2
5 12.11 VEGFA SHH MMP9 CTNNB1
6 11.99 SHH LEF1 CTNNB1 AXIN2
7 11.91 SHH HESX1 CTNNB1
8 11.89 VEGFA MMP9 CTNNB1
9 11.82 HESX1 ESX1 CTNNB1 AXIN2
10 11.42 VEGFA MMP9 CTNNB1
11 11.36 LEF1 CTNNB1 AXIN2
12 11.24 VEGFA SHH CTNNB1
13 11.24 VEGFA MMP9 LEF1 CTNNB1 AXIN2
14 11.15 MMP9 LEF1 CTNNB1 AXIN2
15 10.8 LEF1 CTNNB1
16 10.77 VEGFA LEF1
17 10.71 LEF1 CTNNB1 AXIN2
18 9.62 NDUFAB1 AASDHPPT

GO Terms for Adamantinous Craniopharyngioma

Cellular components related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-catenin destruction complex GO:0030877 9.16 CTNNB1 AXIN2
2 extracellular matrix GO:0031012 9.02 VEGFA SHH MMP9 MMP20 ENAM
3 beta-catenin-TCF complex GO:1990907 8.96 LEF1 CTNNB1

Biological processes related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.99 VEGFA SHH LEF1 HESX1 ESX1 CTNNB1
2 negative regulation of apoptotic process GO:0043066 9.97 VEGFA SHH MMP9 LEF1 CTNNB1
3 kidney development GO:0001822 9.78 VEGFA SHH CTNNB1
4 lung development GO:0030324 9.77 VEGFA SHH CTNNB1
5 canonical Wnt signaling pathway GO:0060070 9.71 SHH LEF1 CTNNB1
6 vasculogenesis GO:0001570 9.7 VEGFA SHH CTNNB1
7 positive regulation of epithelial to mesenchymal transition GO:0010718 9.67 LEF1 CTNNB1 AXIN2
8 hindbrain development GO:0030902 9.63 SHH CTNNB1
9 macrophage differentiation GO:0030225 9.62 VEGFA MMP9
10 male genitalia development GO:0030539 9.62 SHH CTNNB1
11 epithelial tube branching involved in lung morphogenesis GO:0060441 9.61 SHH CTNNB1
12 ectoderm development GO:0007398 9.6 SHH CTNNB1
13 amelogenesis GO:0097186 9.58 MMP20 ENAM
14 embryonic foregut morphogenesis GO:0048617 9.57 SHH CTNNB1
15 lung-associated mesenchyme development GO:0060484 9.56 SHH CTNNB1
16 positive regulation of skeletal muscle tissue development GO:0048643 9.55 SHH CTNNB1
17 beta-catenin-TCF complex assembly GO:1904837 9.54 LEF1 CTNNB1 AXIN2
18 vasculature development GO:0001944 9.5 SHH LEF1 CTNNB1
19 trachea morphogenesis GO:0060439 9.48 SHH CTNNB1
20 regulation of centromeric sister chromatid cohesion GO:0070602 9.46 CTNNB1 AXIN2
21 mesenchymal cell proliferation involved in lung development GO:0060916 9.43 SHH CTNNB1
22 positive regulation of mesenchymal cell proliferation GO:0002053 9.43 VEGFA SHH CTNNB1
23 positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 9.4 SHH CTNNB1
24 positive regulation of neuroblast proliferation GO:0002052 9.33 VEGFA SHH CTNNB1
25 odontogenesis of dentin-containing tooth GO:0042475 9.26 SHH LEF1 ENAM CTNNB1
26 branching involved in blood vessel morphogenesis GO:0001569 8.92 VEGFA SHH LEF1 CTNNB1

Molecular functions related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 I-SMAD binding GO:0070411 8.62 CTNNB1 AXIN2

Sources for Adamantinous Craniopharyngioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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