MCID: ADM001
MIFTS: 34

Adamantinous Craniopharyngioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Adamantinous Craniopharyngioma

MalaCards integrated aliases for Adamantinous Craniopharyngioma:

Name: Adamantinous Craniopharyngioma 12 15 71
Craniopharyngioma, Adamantinomatous 12
Adamantinomatous Craniopharyngioma 17
Adamantinous Rathke's Pouch Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3846
MeSH 43 D003397
NCIt 49 C4726
SNOMED-CT 67 134216001
UMLS 71 C0431129

Summaries for Adamantinous Craniopharyngioma

MalaCards based summary : Adamantinous Craniopharyngioma, also known as craniopharyngioma, adamantinomatous, is related to ameloblastoma and papillary craniopharyngioma, and has symptoms including visual disturbance An important gene associated with Adamantinous Craniopharyngioma is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include endothelial, and related phenotypes are Increased Nanog expression and Increased Nanog expression

Related Diseases for Adamantinous Craniopharyngioma

Diseases related to Adamantinous Craniopharyngioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 ameloblastoma 31.1 SERPINA3 MMP9 CTNNB1
2 papillary craniopharyngioma 30.8 NDUFAB1 ENAM CTNNB1 AASDHPPT
3 pituitary gland disease 29.4 PROP1 POU1F1 HESX1 ESX1
4 craniopharyngioma 28.1 VEGFA SOX2 PROP1 POU1F1 MMP9 LEF1
5 intravascular papillary endothelial hyperplasia 10.5 VEGFA SERPINA3
6 angiokeratoma circumscriptum 10.4 VEGFA MMP9
7 retinal hemangioblastoma 10.4 VEGFA SERPINA3
8 adenoma 10.4
9 pituitary tumors 10.4
10 sick building syndrome 10.4 VEGFA MMP9
11 brain stem medulloblastoma 10.4 SHH CTNNB1
12 odontogenic myxoma 10.3 VEGFA SERPINA3 MMP9
13 embryonal sarcoma 10.3 SERPINA3 CTNNB1
14 lung giant cell carcinoma 10.3 VEGFA SERPINA3 MMP9
15 pulmonary emphysema 10.3 VEGFA SERPINA3 MMP9
16 adenomyosis 10.3 VEGFA MMP9 CTNNB1
17 reproductive organ benign neoplasm 10.3 VEGFA SERPINA3 CTNNB1
18 corneal disease 10.3 VEGFA SERPINA3 MMP9
19 cardiovascular organ benign neoplasm 10.3 VEGFA SERPINA3 CTNNB1
20 vascular dementia 10.3 VEGFA SERPINA3 MMP9
21 central nervous system benign neoplasm 10.2 SERPINA3 CTNNB1 AASDHPPT
22 tuberculous meningitis 10.2 VEGFA MMP9
23 lymphangioma 10.2 VEGFA SERPINA3 CTNNB1
24 congenital hypopituitarism 10.2 PROP1 HESX1
25 pre-malignant neoplasm 10.2 VEGFA SERPINA3 CTNNB1
26 tongue disease 10.2 VEGFA MMP9 CTNNB1
27 periodontitis 10.2 VEGFA SERPINA3 MMP9
28 breast carcinoma in situ 10.2 VEGFA SERPINA3 CTNNB1
29 grade iii astrocytoma 10.2 VEGFA SERPINA3 MMP9
30 colorectal adenoma 10.2 VEGFA MMP9 CTNNB1
31 ovary adenocarcinoma 10.2 VEGFA SERPINA3 CTNNB1
32 holzgreve syndrome 10.2 SOX2 CTNNB1
33 breast cancer 10.2
34 colorectal cancer 10.2
35 meningioma, radiation-induced 10.2
36 familial adenomatous polyposis 10.2
37 hemangioma 10.2
38 astrocytoma 10.2
39 pituitary adenoma 10.2
40 juvenile pilocytic astrocytoma 10.2
41 growth hormone deficiency 10.2
42 ovary epithelial cancer 10.2 VEGFA SERPINA3 CTNNB1
43 colorectal adenocarcinoma 10.2 VEGFA MMP9 CTNNB1
44 malignant ovarian surface epithelial-stromal neoplasm 10.2 VEGFA SERPINA3 CTNNB1
45 bone squamous cell carcinoma 10.2 MMP9 CTNNB1
46 fryns microphthalmia syndrome 10.2 SOX2 HESX1
47 chordoma 10.2 VEGFA SERPINA3 CTNNB1
48 bone inflammation disease 10.2 VEGFA SERPINA3 MMP9
49 ovarian serous cystadenocarcinoma 10.2 VEGFA SERPINA3 CTNNB1
50 keratocystic odontogenic tumor 10.2 SHH MMP9

Graphical network of the top 20 diseases related to Adamantinous Craniopharyngioma:



Diseases related to Adamantinous Craniopharyngioma

Symptoms & Phenotypes for Adamantinous Craniopharyngioma

UMLS symptoms related to Adamantinous Craniopharyngioma:


visual disturbance

GenomeRNAi Phenotypes related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.4 MMP9 PROP1 VEGFA
2 Increased Nanog expression GR00371-A-2 9.4 VEGFA
3 Increased Nanog expression GR00371-A-3 9.4 LEF1 PROP1
4 Increased Nanog expression GR00371-A-4 9.4 VEGFA
5 Increased Nanog expression GR00371-A-5 9.4 LEF1 MMP9 POU1F1 PROP1 VEGFA

MGI Mouse Phenotypes related to Adamantinous Craniopharyngioma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.22 AXIN2 CTNNB1 ENAM HESX1 LEF1 MMP9
2 craniofacial MP:0005382 10.18 AXIN2 CTNNB1 ENAM HESX1 LEF1 POU1F1
3 endocrine/exocrine gland MP:0005379 10.15 AXIN2 CTNNB1 HESX1 LEF1 POU1F1 PROP1
4 mortality/aging MP:0010768 10.14 AASDHPPT AXIN2 CTNNB1 HESX1 LEF1 MMP9
5 nervous system MP:0003631 10.07 AXIN2 CTNNB1 HESX1 LEF1 MMP9 POU1F1
6 integument MP:0010771 10.06 AXIN2 CTNNB1 LEF1 MMP9 SERPINA3 SHH
7 digestive/alimentary MP:0005381 10.05 AXIN2 CTNNB1 ENAM MMP9 SHH SOX2
8 reproductive system MP:0005389 9.97 AXIN2 CTNNB1 LEF1 MMP9 POU1F1 PROP1
9 limbs/digits/tail MP:0005371 9.91 AXIN2 CTNNB1 LEF1 MMP9 SHH VEGFA
10 skeleton MP:0005390 9.81 AXIN2 CTNNB1 ENAM LEF1 MMP9 POU1F1
11 respiratory system MP:0005388 9.8 CTNNB1 HESX1 MMP9 PROP1 SHH SOX2
12 taste/olfaction MP:0005394 9.26 CTNNB1 HESX1 SHH SOX2
13 vision/eye MP:0005391 9.23 AXIN2 CTNNB1 HESX1 LEF1 MMP9 SHH

Drugs & Therapeutics for Adamantinous Craniopharyngioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 0/Feasibility Trial of Tocilizumab in Children and Adolescents With Newly‐ Diagnosed or Recurrent/Progressive Adamantinomatous Craniopharyngioma Recruiting NCT03970226 Early Phase 1 Tocilizumab
2 Advancing Treatment for Pediatric Craniopharyngioma: Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy Recruiting NCT03610906

Search NIH Clinical Center for Adamantinous Craniopharyngioma

Genetic Tests for Adamantinous Craniopharyngioma

Anatomical Context for Adamantinous Craniopharyngioma

MalaCards organs/tissues related to Adamantinous Craniopharyngioma:

40
Endothelial

Publications for Adamantinous Craniopharyngioma

Articles related to Adamantinous Craniopharyngioma:

(show all 11)
# Title Authors PMID Year
1
12 Years delayed postoperative spinal recurrence of craniopharyngioma. Case report and literature review. 61
29199465 2019
2
Noninvasive molecular diagnosis of craniopharyngioma with MRI-based radiomics approach. 61
30616515 2019
3
Craniopharyngioma: a roadmap for scientific translation. 61
29852761 2018
4
Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies. 61
23560577 2013
5
Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. 61
22349813 2012
6
Infrasellar craniopharyngioma of the posterior nasal septum: a rare entity. 61
22582569 2012
7
Expression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngioma. 61
21814723 2011
8
Ectopic recurrence of a craniopharyngioma in a 15-year-old girl 9 years after surgery and conventional radiotherapy: case report. 61
21221975 2011
9
Glare in a Case of a Craniopharyngioma. 61
30151024 2011
10
MR differentiation of adamantinous and squamous-papillary craniopharyngiomas. 61
9010523 1997
11
Ossified adamantinous type craniopharyngiomas. A series of 13 patients. 61
7942198 1994

Variations for Adamantinous Craniopharyngioma

Expression for Adamantinous Craniopharyngioma

Search GEO for disease gene expression data for Adamantinous Craniopharyngioma.

Pathways for Adamantinous Craniopharyngioma

Pathways related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 VEGFA MMP9 LEF1 CTNNB1 AXIN2
2 12.57 VEGFA SHH MMP9 LEF1 CTNNB1 AXIN2
3
Show member pathways
12.51 VEGFA MMP9 LEF1 CTNNB1
4
Show member pathways
12.37 SOX2 LEF1 CTNNB1 AXIN2
5
Show member pathways
12.18 SHH LEF1 CTNNB1 AXIN2
6 12.16 VEGFA SHH MMP9 CTNNB1
7
Show member pathways
12.06 SOX2 LEF1 CTNNB1 AXIN2
8 11.95 VEGFA MMP9 CTNNB1
9 11.95 SOX2 LEF1 CTNNB1 AXIN2
10 11.92 VEGFA SOX2 SHH
11 11.89 SOX2 SHH HESX1 CTNNB1
12 11.82 VEGFA SOX2 MMP9
13 11.81 SOX2 SHH LEF1 CTNNB1 AXIN2
14 11.64 VEGFA SOX2 SHH
15 11.57 VEGFA MMP9 LEF1 CTNNB1 AXIN2
16 11.48 VEGFA MMP9 CTNNB1
17 11.46 MMP9 LEF1 CTNNB1 AXIN2
18 11.42 SOX2 HESX1 ESX1
19 11.42 LEF1 CTNNB1 AXIN2
20 11.33 VEGFA SHH CTNNB1
21 11.29 SOX2 LEF1 CTNNB1
22 11.18 SOX2 HESX1 ESX1 CTNNB1 AXIN2
23 10.89 VEGFA SERPINA3
24 10.88 LEF1 CTNNB1 AXIN2
25 10.86 LEF1 CTNNB1
26 10.83 VEGFA LEF1
27 9.71 NDUFAB1 AASDHPPT

GO Terms for Adamantinous Craniopharyngioma

Cellular components related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.46 VEGFA SHH MMP9 ENAM
2 beta-catenin destruction complex GO:0030877 9.26 CTNNB1 AXIN2
3 beta-catenin-TCF complex GO:1990907 8.96 LEF1 CTNNB1
4 transcription factor complex GO:0005667 8.92 SOX2 PROP1 LEF1 CTNNB1

Biological processes related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.18 SOX2 SHH PROP1 POU1F1 LEF1 HESX1
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 VEGFA SOX2 SHH PROP1 POU1F1 LEF1
3 positive regulation of transcription, DNA-templated GO:0045893 10.04 SOX2 SHH POU1F1 LEF1 CTNNB1
4 positive regulation of cell proliferation GO:0008284 10.03 VEGFA SHH POU1F1 LEF1 CTNNB1
5 negative regulation of apoptotic process GO:0043066 9.93 VEGFA SHH PROP1 MMP9 LEF1 CTNNB1
6 kidney development GO:0001822 9.83 VEGFA SHH CTNNB1
7 lung development GO:0030324 9.81 VEGFA SHH CTNNB1
8 forebrain development GO:0030900 9.79 SOX2 SHH CTNNB1
9 vasculogenesis GO:0001570 9.77 VEGFA SHH CTNNB1
10 positive regulation of epithelial to mesenchymal transition GO:0010718 9.76 LEF1 CTNNB1 AXIN2
11 dorsal/ventral pattern formation GO:0009953 9.73 SHH PROP1 CTNNB1
12 cell fate specification GO:0001708 9.69 SHH POU1F1 CTNNB1
13 vasculature development GO:0001944 9.67 SHH LEF1 CTNNB1
14 canonical Wnt signaling pathway GO:0060070 9.67 SHH PROP1 LEF1 CTNNB1
15 male genitalia development GO:0030539 9.66 SHH CTNNB1
16 epithelial tube branching involved in lung morphogenesis GO:0060441 9.65 SHH CTNNB1
17 ectoderm development GO:0007398 9.65 SHH CTNNB1
18 beta-catenin-TCF complex assembly GO:1904837 9.65 LEF1 CTNNB1 AXIN2
19 lung-associated mesenchyme development GO:0060484 9.62 SHH CTNNB1
20 embryonic foregut morphogenesis GO:0048617 9.62 SHH CTNNB1
21 odontogenesis of dentin-containing tooth GO:0042475 9.62 SHH LEF1 ENAM CTNNB1
22 positive regulation of skeletal muscle tissue development GO:0048643 9.61 SHH CTNNB1
23 positive regulation of mesenchymal cell proliferation GO:0002053 9.61 VEGFA SHH CTNNB1
24 trachea morphogenesis GO:0060439 9.58 SHH CTNNB1
25 positive regulation of neuroblast proliferation GO:0002052 9.58 VEGFA SHH CTNNB1
26 somatotropin secreting cell differentiation GO:0060126 9.57 PROP1 POU1F1
27 regulation of centromeric sister chromatid cohesion GO:0070602 9.55 CTNNB1 AXIN2
28 mesenchymal cell proliferation involved in lung development GO:0060916 9.54 SHH CTNNB1
29 positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 9.52 SHH CTNNB1
30 branching involved in blood vessel morphogenesis GO:0001569 9.46 VEGFA SHH LEF1 CTNNB1
31 adenohypophysis development GO:0021984 9.43 SOX2 PROP1 POU1F1
32 negative regulation of transcription by RNA polymerase II GO:0000122 9.28 VEGFA SOX2 SHH PROP1 POU1F1 LEF1
33 pituitary gland development GO:0021983 9.26 SOX2 PROP1 POU1F1 HESX1

Molecular functions related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.73 SOX2 PROP1 POU1F1 LEF1 HESX1 ESX1
2 chromatin binding GO:0003682 9.55 PROP1 POU1F1 LEF1 HESX1 CTNNB1
3 sequence-specific DNA binding GO:0043565 9.43 SOX2 PROP1 POU1F1 LEF1 HESX1 ESX1
4 I-SMAD binding GO:0070411 9.32 CTNNB1 AXIN2
5 beta-catenin binding GO:0008013 8.92 PROP1 LEF1 CTNNB1 AXIN2

Sources for Adamantinous Craniopharyngioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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