MCID: ADM001
MIFTS: 27

Adamantinous Craniopharyngioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Adamantinous Craniopharyngioma

MalaCards integrated aliases for Adamantinous Craniopharyngioma:

Name: Adamantinous Craniopharyngioma 12 15 74
Craniopharyngioma, Adamantinomatous 12
Adamantinomatous Craniopharyngioma 17
Adamantinous Rathke's Pouch Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3846
MeSH 45 D003397
NCIt 51 C4726
UMLS 74 C0431129

Summaries for Adamantinous Craniopharyngioma

MalaCards based summary : Adamantinous Craniopharyngioma, also known as craniopharyngioma, adamantinomatous, is related to papillary craniopharyngioma and angiokeratoma circumscriptum, and has symptoms including visual disturbance An important gene associated with Adamantinous Craniopharyngioma is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are G-Beta Gamma Signaling and Proteoglycans in cancer. Affiliated tissues include endothelial.

Related Diseases for Adamantinous Craniopharyngioma

Diseases related to Adamantinous Craniopharyngioma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 41, show less)
# Related Disease Score Top Affiliating Genes
1 papillary craniopharyngioma 29.8 CTNNB1 DNAH12 DNAH2 DNAH7
2 angiokeratoma circumscriptum 10.3 MMP9 VEGFA
3 sick building syndrome 10.3 MMP9 VEGFA
4 ischemic colitis 10.3 MMP9 VEGFA
5 odontogenic myxoma 10.3 MMP9 VEGFA
6 tuberculous meningitis 10.2 MMP9 VEGFA
7 rosacea 10.2 MMP9 VEGFA
8 craniopharyngioma 10.2
9 psammomatous meningioma 10.2 CTNNB1 MMP9
10 arteriovenous malformation 10.2 MMP9 VEGFA
11 adenomyosis 10.2 MMP9 VEGFA
12 keratitis, hereditary 10.2 MMP9 VEGFA
13 severe pre-eclampsia 10.2 MMP9 VEGFA
14 ameloblastoma 10.2
15 cystadenoma 10.2
16 pituitary adenoma 10.2
17 adenoma 10.2
18 pituitary tumors 10.2
19 cervix disease 10.2 CTNNB1 VEGFA
20 grade iii astrocytoma 10.1 MMP9 VEGFA
21 exudative vitreoretinopathy 1 10.1 CTNNB1 VEGFA
22 uterine anomalies 10.1 CTNNB1 VEGFA
23 varicose veins 10.1 MMP9 VEGFA
24 nasopharyngeal disease 10.1 CTNNB1 MMP9 VEGFA
25 pharynx cancer 10.1 CTNNB1 MMP9 VEGFA
26 male reproductive organ cancer 10.1 CTNNB1 MMP9 VEGFA
27 stomach disease 10.1 CTNNB1 MMP9 VEGFA
28 female reproductive system disease 10.1 CTNNB1 MMP9 VEGFA
29 reproductive system disease 10.1 CTNNB1 MMP9 VEGFA
30 respiratory system cancer 10.0 CTNNB1 MMP9 VEGFA
31 gastrointestinal system cancer 10.0 CTNNB1 MMP9 VEGFA
32 endocrine gland cancer 10.0 CTNNB1 MMP9 VEGFA
33 gastrointestinal system disease 10.0 CTNNB1 MMP9 VEGFA
34 pancreas adenocarcinoma 10.0 CTNNB1 MMP9 VEGFA
35 adamantinoma of long bones 10.0 CTNNB1 MMP9 VEGFA
36 squamous cell carcinoma, head and neck 10.0 CTNNB1 MMP9 VEGFA
37 large intestine cancer 10.0 CTNNB1 MMP9 VEGFA
38 colonic disease 10.0 CTNNB1 VEGFA
39 gastric adenocarcinoma 9.9 CTNNB1 MMP9 VEGFA
40 lung cancer susceptibility 3 9.9 CTNNB1 MMP9 VEGFA
41 tongue cancer 9.9 CTNNB1 MMP9

Graphical network of the top 20 diseases related to Adamantinous Craniopharyngioma:



Diseases related to Adamantinous Craniopharyngioma

Symptoms & Phenotypes for Adamantinous Craniopharyngioma

UMLS symptoms related to Adamantinous Craniopharyngioma:


visual disturbance

Drugs & Therapeutics for Adamantinous Craniopharyngioma

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy Recruiting NCT03610906

Search NIH Clinical Center for Adamantinous Craniopharyngioma

Genetic Tests for Adamantinous Craniopharyngioma

Anatomical Context for Adamantinous Craniopharyngioma

MalaCards organs/tissues related to Adamantinous Craniopharyngioma:

42
Endothelial

Publications for Adamantinous Craniopharyngioma

Articles related to Adamantinous Craniopharyngioma:

(showing 1, show less)
# Title Authors Year
1
Expression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngioma. ( 21814723 )
2011

Variations for Adamantinous Craniopharyngioma

Expression for Adamantinous Craniopharyngioma

Search GEO for disease gene expression data for Adamantinous Craniopharyngioma.

Pathways for Adamantinous Craniopharyngioma

GO Terms for Adamantinous Craniopharyngioma

Cellular components related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

(showing 7, show less)
# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.72 CTNNB1 DNAH12 DNAH2 DNAH7 TUBA4A
2 cell projection GO:0042995 9.67 CTNNB1 DNAH12 DNAH2 DNAH7
3 cilium GO:0005929 9.58 DNAH12 DNAH2 DNAH7
4 presynaptic active zone cytoplasmic component GO:0098831 9.26 CTNNB1 RIMS1
5 microtubule GO:0005874 9.26 DNAH12 DNAH2 DNAH7 TUBA4A
6 axonemal dynein complex GO:0005858 9.16 DNAH2 DNAH7
7 dynein complex GO:0030286 8.8 DNAH12 DNAH2 DNAH7

Biological processes related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

(showing 8, show less)
# Name GO ID Score Top Affiliating Genes
1 vasculogenesis GO:0001570 9.43 CTNNB1 VEGFA
2 cell maturation GO:0048469 9.4 CTNNB1 VEGFA
3 branching involved in blood vessel morphogenesis GO:0001569 9.37 CTNNB1 VEGFA
4 positive regulation of mesenchymal cell proliferation GO:0002053 9.32 CTNNB1 VEGFA
5 positive regulation of neuroblast proliferation GO:0002052 9.26 CTNNB1 VEGFA
6 cilium-dependent cell motility GO:0060285 9.16 DNAH2 DNAH7
7 macrophage differentiation GO:0030225 8.96 MMP9 VEGFA
8 microtubule-based movement GO:0007018 8.8 DNAH12 DNAH2 DNAH7

Molecular functions related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 dynein intermediate chain binding GO:0045505 9.37 DNAH2 DNAH7
2 dynein light intermediate chain binding GO:0051959 9.32 DNAH2 DNAH7
3 dynein light chain binding GO:0045503 9.26 DNAH2 DNAH7
4 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 9.16 DNAH2 DNAH7
5 motor activity GO:0003774 9.13 DNAH12 DNAH2 DNAH7
6 microtubule motor activity GO:0003777 8.8 DNAH12 DNAH2 DNAH7

Sources for Adamantinous Craniopharyngioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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