MCID: ADN016
MIFTS: 65

Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adenocarcinoma

MalaCards integrated aliases for Adenocarcinoma:

Name: Adenocarcinoma 12 55 6 44 15 17 72
Adenocarcinomas 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:299
MeSH 44 D000230
NCIt 50 C2852
SNOMED-CT 68 35917007
UMLS 72 C0001418

Summaries for Adenocarcinoma

Disease Ontology : 12 A carcinoma that has material basis in abnormally proliferating cells, derives from epithelial cells, which originate in glandular tissue.

MalaCards based summary : Adenocarcinoma, also known as adenocarcinomas, is related to papillary adenocarcinoma and mucinous adenocarcinoma. An important gene associated with Adenocarcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. The drugs Aluminum hydroxide and Iron isomaltoside 1000 have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and colon, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 75 Adenocarcinoma (/EOA|dEanoESkE'E?rsEaE^noESmET/; plural adenocarcinomas or adenocarcinomata... more...

Related Diseases for Adenocarcinoma

Diseases in the Adenocarcinoma family:

Adenocarcinoma in Situ

Diseases related to Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2278)
# Related Disease Score Top Affiliating Genes
1 papillary adenocarcinoma 35.2 TP53 ERBB2 CDH1
2 mucinous adenocarcinoma 35.1 MLH1 KRAS EGFR CDKN2A
3 bronchiolo-alveolar adenocarcinoma 35.0 KRAS EGFR CDH1
4 aggressive digital papillary adenocarcinoma 35.0 PIK3CA KRAS HRAS
5 gastric papillary adenocarcinoma 34.9 TP53 ERBB2
6 mucinous lung adenocarcinoma 34.9 KRAS HRAS ERBB2 EGFR
7 cervical adenocarcinoma 34.8 TP53 ERBB2 CDKN2A
8 ovary adenocarcinoma 34.8 TP53 PIK3CA KRAS HRAS ERBB2
9 barrett's adenocarcinoma 34.8 TP53 KRAS ERBB2 CDKN2A
10 colon adenocarcinoma 34.7 MLH1 KRAS CTNNB1 CDH1 APC
11 nasal cavity adenocarcinoma 34.7 TP53 KRAS HRAS CDKN2A
12 uterine corpus serous adenocarcinoma 34.7 TP53 PIK3CA ERBB2
13 vulvar adenocarcinoma 34.7 TP53 RB1
14 cecum adenocarcinoma 34.7 MLH1 KRAS HRAS
15 endometrial adenocarcinoma 34.6 TP53 MLH1 KRAS ERBB2 EGFR CTNNB1
16 barrett esophagus 34.6 TP53 ERBB2 CDKN2A APC
17 fallopian tube endometrioid adenocarcinoma 34.6 ERBB2 CDKN2A
18 colorectal adenocarcinoma 34.4 TP53 MLH1 KRAS HRAS EGFR CTNNB1
19 urachal adenocarcinoma 34.4 KRAS BRAF
20 rare adenocarcinoma of the breast 34.4 TP53 PIK3CA KRAS AKT1
21 bile duct adenocarcinoma 34.2 TP53 KRAS HRAS EPCAM CDH1 AKT1
22 adenosquamous carcinoma 34.2 TP53 PIK3CA KRAS EGFR
23 esophagus adenocarcinoma 34.1 TP53 SMAD4 HNF1A-AS1 ERBB2
24 suppression of tumorigenicity 12 33.8 TP53 SMAD4 PIK3CA HRAS CTNNB1 CDH1
25 serous cystadenocarcinoma 33.6 TP53 PIK3CA HRAS ERBB2 AKT1
26 renal cell carcinoma, papillary, 1 33.6 TP53 PIK3CA HRAS ERBB2 BRAF
27 adenosquamous lung carcinoma 33.6 PIK3CA KRAS HRAS ERBB2 EGFR
28 breast adenocarcinoma 33.5 TP53 SMAD4 PIK3CA KRAS H19 ERBB2
29 inflammatory breast carcinoma 33.4 ERBB2 EGFR CDH1
30 cystadenocarcinoma 33.4 TP53 PIK3CA HRAS ERBB2 AKT1
31 hidradenocarcinoma 33.4 TP53 ERBB2 EGFR
32 carcinosarcoma 33.4 TP53 PIK3CA KRAS HRAS ERBB2 CTNNB1
33 primary peritoneal carcinoma 33.4 TP53 ERBB2 EGFR
34 adenoid cystic carcinoma 33.3 TP53 PIK3CA KRAS HRAS ERBB2 CTNNB1
35 adenoma 33.3 TP53 TGFBR2 SMAD4 MLH1 KRAS CTNNB1
36 colorectal adenoma 33.3 TP53 MLH1 KRAS HRAS CTNNB1 APC
37 ovarian serous cystadenocarcinoma 33.3 TP53 PIK3CA HRAS ERBB2 BRAF AKT1
38 lung squamous cell carcinoma 33.2 TP53 PIK3CA KRAS HRAS EGFR CDH1
39 esophageal cancer 32.4 TP53 TGFBR2 SMAD4 RB1 PIK3CA KRAS
40 gastric adenocarcinoma 32.3 TP53 TGFBR2 SMAD4 PIK3CA MLH1 KRAS
41 small cell carcinoma 32.2 TP53 EGFR CDKN2A
42 in situ carcinoma 32.2 TP53 ERBB2 EGFR CDKN2A CDH1
43 suppressor of tumorigenicity 3 32.1 TP53 RB1 CDKN2A
44 exanthem 32.1 KRAS HRAS ERBB2 EGFR
45 lung cancer susceptibility 3 32.1 TP53 TGFBR2 SMAD4 PIK3CA KRAS HRAS
46 intrahepatic cholangiocarcinoma 32.0 TP53 KRAS EGFR CTNNB1 CDH1
47 peutz-jeghers syndrome 32.0 TP53 SMAD4 CTNNB1 APC
48 colitis 31.9 SMAD4 MLH1 CTNNB1 AKT1
49 gastrointestinal stromal tumor 31.9 TP53 KRAS EGFR CDKN2A BRAF AKT1
50 transitional cell carcinoma 31.9 TP53 HRAS ERBB2 EGFR CDKN2A CDH1

Graphical network of the top 20 diseases related to Adenocarcinoma:



Diseases related to Adenocarcinoma

Symptoms & Phenotypes for Adenocarcinoma

GenomeRNAi Phenotypes related to Adenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 11.2 BRAF KRAS HRAS EGFR PIK3CA
2 Decreased viability GR00106-A-0 11.2 KRAS
3 Decreased viability GR00107-A-1 11.2 TGFBR2
4 Decreased viability GR00221-A-1 11.2 CDH1 KRAS AKT1 CDKN2A HRAS TGFBR2
5 Decreased viability GR00221-A-2 11.2 KRAS AKT1 HRAS PIK3CA
6 Decreased viability GR00221-A-3 11.2 AKT1 CDKN2A ERBB2 HRAS TGFBR2
7 Decreased viability GR00221-A-4 11.2 BRAF AKT1 CDKN2A ERBB2 TGFBR2 EGFR
8 Decreased viability GR00301-A 11.2 BRAF CDH1 ERBB4 KRAS
9 Decreased viability GR00342-S-1 11.2 ERBB4
10 Decreased viability GR00381-A-1 11.2 BRAF KRAS
11 Decreased viability GR00402-S-2 11.2 BRAF CDH1 ERBB4 KRAS AKT1 CDKN2A
12 Decreased viability in esophageal squamous lineage GR00235-A 10.17 APC BRAF CDH1 CDKN2A CTNNB1 ERBB2
13 Decreased cell migration GR00055-A-1 10.03 AKT1 BRAF CTNNB1 EGFR ERBB4 HRAS
14 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.95 APC CTNNB1 EGFR EPCAM ERBB2 ERBB4
15 Increased cell death HMECs cells GR00103-A-0 9.73 CTNNB1 EGFR ERBB4 PIK3CA TGFBR2 TP53
16 Increased cell migration GR00055-A-3 9.7 BRAF CTNNB1 EGFR ERBB4 HRAS KRAS
17 Increased cell viability after pRB stimulation GR00230-A-1 9.35 AKT1 EGFR ERBB2 ERBB4 TGFBR2
18 Reduced mammosphere formation GR00396-S 9.17 BRAF CDH1 EGFR H19 HRAS KRAS

MGI Mouse Phenotypes related to Adenocarcinoma:

46 (show all 28)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.56 AKT1 APC BRAF CDH1 CDKN2A CTNNB1
2 cellular MP:0005384 10.55 AKT1 APC BRAF CDH1 CDKN2A CTNNB1
3 endocrine/exocrine gland MP:0005379 10.55 AKT1 APC BRAF CDH1 CDKN2A CTNNB1
4 behavior/neurological MP:0005386 10.51 AKT1 APC BRAF CDKN2A CTNNB1 EPCAM
5 embryo MP:0005380 10.51 AKT1 APC BRAF CDH1 CDKN2A CTNNB1
6 homeostasis/metabolism MP:0005376 10.5 AKT1 APC BRAF CDH1 CDKN2A CTNNB1
7 digestive/alimentary MP:0005381 10.49 APC BRAF CDH1 CDKN2A CTNNB1 EGFR
8 growth/size/body region MP:0005378 10.49 AKT1 APC BRAF CDH1 CDKN2A CTNNB1
9 immune system MP:0005387 10.46 AKT1 APC BRAF CDH1 CDKN2A CTNNB1
10 mortality/aging MP:0010768 10.46 AKT1 APC BRAF CDH1 CDKN2A CTNNB1
11 integument MP:0010771 10.45 AKT1 APC BRAF CDH1 CDKN2A CTNNB1
12 hematopoietic system MP:0005397 10.42 AKT1 APC BRAF CDKN2A CTNNB1 EGFR
13 craniofacial MP:0005382 10.4 APC BRAF CTNNB1 EGFR ERBB2 ERBB4
14 neoplasm MP:0002006 10.38 AKT1 APC BRAF CDH1 CDKN2A CTNNB1
15 nervous system MP:0003631 10.36 AKT1 APC BRAF CDKN2A CTNNB1 EGFR
16 muscle MP:0005369 10.34 AKT1 APC BRAF CDKN2A CTNNB1 EGFR
17 liver/biliary system MP:0005370 10.26 AKT1 APC BRAF CDKN2A CTNNB1 EGFR
18 normal MP:0002873 10.25 AKT1 APC BRAF CDH1 CTNNB1 EGFR
19 adipose tissue MP:0005375 10.24 AKT1 APC BRAF EGFR PIK3CA RB1
20 limbs/digits/tail MP:0005371 10.19 APC BRAF CTNNB1 EGFR ERBB2 KRAS
21 hearing/vestibular/ear MP:0005377 10.13 APC BRAF CTNNB1 EGFR KRAS RB1
22 no phenotypic analysis MP:0003012 10.13 CDH1 CDKN2A CTNNB1 EGFR EPCAM HRAS
23 reproductive system MP:0005389 10.13 AKT1 APC BRAF CDH1 CDKN2A CTNNB1
24 pigmentation MP:0001186 9.97 APC BRAF CDKN2A CTNNB1 EGFR KRAS
25 renal/urinary system MP:0005367 9.97 APC BRAF CTNNB1 EGFR HRAS KRAS
26 respiratory system MP:0005388 9.97 AKT1 BRAF CDKN2A CTNNB1 EGFR ERBB2
27 skeleton MP:0005390 9.8 AKT1 APC BRAF CDKN2A CTNNB1 EGFR
28 vision/eye MP:0005391 9.36 APC BRAF CDKN2A CTNNB1 EGFR KRAS

Drugs & Therapeutics for Adenocarcinoma

Drugs for Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 831)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aluminum hydroxide Approved, Investigational Phase 4 21645-51-2
2
Iron isomaltoside 1000 Approved, Investigational Phase 4 1370654-58-2
3
Pravastatin Approved Phase 4 81093-37-0 54687
4
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
5
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
6
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 23925 27284
7
Prilocaine Approved Phase 4 721-50-6 4906
8
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
9
Clarithromycin Approved Phase 4 81103-11-9 84029
10
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
11
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
12
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
13
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
14
Ofloxacin Approved Phase 4 82419-36-1 4583
15
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
16
Nitazoxanide Approved, Investigational, Vet_approved Phase 4 55981-09-4 41684
17
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
18
Desflurane Approved Phase 4 57041-67-5 42113
19
Fesoterodine Approved Phase 4 286930-03-8, 286930-02-7 6918558
20
Sodium citrate Approved, Investigational Phase 4 68-04-2
21
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
22
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
23
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
24
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
25
tannic acid Approved Phase 4 1401-55-4
26
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
27
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
28
Zinc Approved, Investigational Phase 4 7440-66-6 32051
29
Trastuzumab Approved, Investigational Phase 4 180288-69-1 9903
30
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
31
Polaprezinc Experimental Phase 4 107667-60-7
32
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
33 Endostar protein Phase 4
34 Endostatins Phase 4 71581480
35 Monophosphoryl lipid A Phase 4
36 Respiratory System Agents Phase 4
37 Expectorants Phase 4
38 Chelating Agents Phase 4
39 Excitatory Amino Acid Antagonists Phase 4
40 Anesthetics, Dissociative Phase 4
41 Excitatory Amino Acids Phase 4
42 Anticoagulants Phase 4
43 Cytochrome P-450 CYP3A Inhibitors Phase 4
44 Hepcidins Phase 4
45 Ferric Compounds Phase 4
46 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
47 Epoetin alfa Phase 4 113427-24-0
48 Iron Supplement Phase 4
49 diuretics Phase 4
50 Natriuretic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 4489)
# Name Status NCT ID Phase Drugs
1 Comparative Clinical Trial of Erlotinib and Pemetrexed for Maintenance Treatment in Lung Adenocarcinoma Unknown status NCT02399566 Phase 4 Erlotinib, Pemetrexed
2 A Randomized ,Opened, Prospective Controlled Trial of Clinical Effectiveness for Icotinib as the Adjunctive Treatment After Surgery in Stage I-IIIB Lung Adenocarcinoma Patients With Epidermal Growth Factor Receptor Gene Mutation Unknown status NCT02283424 Phase 4 Icotinib;chemotherapy (Carboplatin and Docetaxel)
3 Recombinant Human Endostatin Durative Transfusion Combined With Pemetrexed Plus Cisplatin or Carboplatin in the First-line Treatment of Advanced Lung Adenocarcinoma With Wild-type EGFR or ALK-negative Unknown status NCT02804646 Phase 4 recombinant human endostatin;pemetrexed plus cisplatin or carboplatin
4 Sequential Icotinib Plus Chemotherapy Versus Icotinib Alone as First-line Treatment in Stage IIIB/IV Lung Adenocarcinoma: a Randomized, Open-label, Multicenter Study Unknown status NCT02103257 Phase 4 Sequential Icotinib Plus Chemotherapy;Icotinib
5 An Open Label, Single Group Assigned, Multicenter Study of Apatinib in Patients With Chemo-refractory Advanced or Metastatic Adenocarcinoma of Stomach or Gastroesophageal Junction Unknown status NCT02426034 Phase 4 Apatinib
6 Randomized, Open Label, Positive Controlled, Multicenter Trial to Evaluate Icotinib as First-line and Maintenance Treatment in EGFR Mutated Patients With Lung Adenocarcinoma Unknown status NCT01665417 Phase 4 Experimental;Chemotherapy;Chemotherapy
7 An Pilot Study to Assess the Efficacy of Intravenous Iron Isomaltoside 1000 (Monofer®) in the Management of Anaemia Associated With the Palliative Management of Oesophagogastric Adenocarcinoma Unknown status NCT01927328 Phase 4 Iron isomaltoside 1000
8 A Prospective, Randomized, Controlled, Multicenter Study of Kanglaite Injection for the Treatment of Cancer Cachexia Unknown status NCT02553187 Phase 4 Kanglaite Injection
9 HPV Vaccination Impact on Cervical Cancer Screening Program: FASTER-Tlalpan Study in Mexico Unknown status NCT03105856 Phase 4
10 Sequential and Maintenance Icotinib Plus Chemotherapy Versus Icotinib Maintenance After Chemotherapy in Untreated Advanced Non-small-cell Lung Cancer: a Randomized, Open-label Study Unknown status NCT02194556 Phase 4 Sequential and maintenance icotinib;Maintenance icotinib
11 Study of Cetuximab in Combination With Chemotherapy for the First Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI
12 Study of the Relationship Between the Rate of Residual Platinum in the Blood and the Incidence of Persistent Neurotoxicity in Patients Treated for Gastrointestinal Cancer With Oxaliplatin Unknown status NCT00274885 Phase 4 oxaliplatin
13 Phase 4, Prospective, Randomized and Comparative Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice Unknown status NCT01273441 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
14 Randomized Controlled Study to Evaluate the Efficacy of Pravastatin on Survival and Recurrence of Advanced Gastroesophageal Cancer Unknown status NCT01038154 Phase 4 Pravastatin
15 Endoesophageal Cryotherapy: A New Technique For Ablating Barrett's Esophagus And Early Stage Esophageal Cancer Unknown status NCT00628784 Phase 4
16 Phase IV Trial to Use Stereotactic Body Radiotherapy for Head and Neck Tumors Completed NCT01344356 Phase 4
17 Endoscopic Ultrasound-guided Celiac Plexus Neurolysis (EUS-CPN) With Alcohol in Patients With Locally Advanced and Unresectable Pancreatic Adenocarcinoma: A Randomized Pilot Study Completed NCT00578279 Phase 4 dehydrated alcohol
18 A Phase IV Open-Label, Descriptive Study to Evaluate the Safety and Effectiveness on the Incidence of HPV 6, 11, 16 and 18 Related CIN 2/3 or Worse of the Quadrivalent HPV (Types 6, 11, 16, 18) L1 Virus-Like Particle (VLP) Vaccine in 16- to 26-Year-Old Japanese Women Completed NCT01544478 Phase 4
19 Open Label Study of Erlotinib (Tarceva®) as Single Agent First Line Treatment of Patients With Locally Advanced or Metastatic Lung Adenocarcinoma With Activating Epidermal Growth Factor Receptor (EGFR) Mutations Completed NCT01609543 Phase 4 erlotinib [Tarceva]
20 Clinical Outcomes of Endoscopic Resection for Treating Extremely Well Differentiated Intestinal-type Adenocarcinoma (WHYX Lesion) Completed NCT01451034 Phase 4
21 Effects of Local Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Inflammatory Cytokines Response After Total Abdominal Hysterectomy Completed NCT03164590 Phase 4 Ketamine;dexmedetomidine;bupivacaine
22 Endoscopic Detection of Small Bowel Dysplasia and Cancer in Patients With Jejuna or Ileal Crohn Disease : Prospective Study in a Cohort of High Risk Patients Completed NCT01180452 Phase 4
23 An Open Label Study of Intravenous Iron (FERINJECT) in Colorectal Adenocarcinoma Related Anaemia to Identify Potential Biomarkers of Responsiveness to Intravenous Iron Completed NCT02057471 Phase 4 Intravenous ferric carboxymaltose
24 A Pharmacokinetic Study of Adjuvant Capecitabine in Patients Who Have Undergone Proximal Pancreatico-duodenectomy for Resection of Pancreatic Adenocarcinoma Completed NCT00854477 Phase 4 capecitabine
25 Prospective Randomized Study of Single Incision Laparoscopic Surgery Versus Conventional Laparoscopic Surgery for Rectal Cancer Completed NCT01579721 Phase 4
26 Impact of Local Anesthesia Type on Cancer Detection Rate in Transrectal Ultrasound Guided Prostate Biopsy Completed NCT02025361 Phase 4 intrarectal lidocaine gel;periprostatic nerve blockade
27 Safety and Efficacy of Nab-paclitaxel (Abraxane) in Combination With Carboplatin as First Line Treatment in Elderly Subjects With Advance Non-Small Cell Lung Cancer (NSCLC): A Phase IV, Randomized, Open-Label, Multicenter Study (Abound.70+) Completed NCT02151149 Phase 4 nab-paclitaxel;Carboplatin
28 A 12 Month Open Label Study of Serum Testosterone Recovery and PSA After Neo-Adjuvant Treatment With Eligard(TM) 22.5mg Used With Radiation Therapy in Patients With Early Prostate Cancer Completed NCT01136226 Phase 4 Eligard (TM)
29 A Phase II Trial Evaluating Irinotecan and Capecitabine in Patients With Relapsed/Refractory Upper Gastrointestinal Tumours Completed NCT00220168 Phase 4 Irinotecan, Capecitabine
30 Early Assessment of the Response to Neo-adjuvant Chemotherapy in Breast Cancer Patients With FDG-PET Completed NCT00904410 Phase 4
31 Comparison of Dexlansoprazole-based Triple and Rabeprazole-based Triple Therapies for Helicobacter Pylori Infection Completed NCT02541786 Phase 4 dexlansoprazole based triple therapy;rabeprazole-based triple therapy
32 An Open Label Study to Determine the Efficacy of Ferric Carboxymaltose in Preoperative Colorectal Cancer Related Anaemia, and to Develop Biomarkers to Predict Response to This Treatment Strategy Completed NCT01701310 Phase 4 Ferric carboxymaltose;Ferrous Sulphate
33 Dual Therapy With High Doses of Ilaprazole and Amoxicillin for Helicobacter Pylori Infection; Studies From Korea Completed NCT02401477 Phase 4 Ilaprazole + Amoxicillin
34 Effects of Preoperative Administration of Oral Rabeprazole on the Prevention of Ulcer Bleeding Following Endoscopic Mucosal Resection(EMR): Prospective, Randomized, Placebo-controlled, Comparative Study Completed NCT00844675 Phase 4 rabeprazole;placebo
35 An Open-Label Study Using the MedPulser Electroporation System to Treat Cutaneous and Subcutaneous Foci of Cancer Completed NCT00198276 Phase 4
36 Study of Avastin in Combination With Chemotherapy for the First Line Treatment of RAS Mutant Unresectable Colorectal Liver-limited Metastases Completed NCT01972490 Phase 4 avastin+chemotherapy of mFOLFOX6 or FOLFIRI;chemotherapy of mFOLFOX6 or FOLFIRI
37 Phase IV/II Open-label Study to Evaluate Prompt Response to Treatment With Cisplatin, Gemcitabine and Bevacizumab in Patients With Non-small Lung Cancer. Completed NCT02316327 Phase 4 gemcitabine, cisplatin and bevacizumab
38 Management Of Anemia Under RadioChemotherapy (MARCH): An Open, Randomized Multicenter Study Of The Effect Of NeoRecormon On Treatment Outcome In Patients With Advanced Cervical Cancer Stage IIB -IVA Treated With Primary Simultaneous Radiochemotherapy (Radiotherapy Plus Cisplatin) Completed NCT00046969 Phase 4 cisplatin
39 A Randomized Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection Completed NCT01219764 Phase 4 Rabeprazole, metronidazole, Clarithromycin, Amoxicillin
40 Prospective, Randomized Controlled Trial Comparing High Dose Amoxicillin Versus Tetracycline Based Quadruple Therapy as Second-line Treatment for Resistant Helicobacter Pylori Infection Completed NCT02175927 Phase 4 Lansoprazole;Bismuth Potassium Citrate;Metronidazole;Amoxicillin;Tetracycline
41 Comparison Between Hybrid, Reverse Hybrid, and Non-Bismuth Levofloxacin Quadruple Regimens for Helicobacter Pylori Infection in Egypt: A Randomized Controlled Trial Completed NCT04039412 Phase 4 Hybrid regimen;Reverse hybrid regimen;Levofloxacin quadruple regimen
42 Endoscopic Radiofrequency Ablation for Malignant Biliary Obstruction Completed NCT01758341 Phase 4
43 Resectable Pancreatic Adenocarcinoma - Does the Type of Anesthesia Have an Impact on Circulating Tumor Cells? Recruiting NCT02335151 Phase 4 Desflurane
44 The Effect of Gemcitabine Plus Nab-paclitaxel as Secondary Chemotherapy in Advanced Pancreatic Cancer Recruiting NCT03401827 Phase 4 Chemotherapy (Gemcitabine + nab-paclitaxel)
45 A Pilot Trial of Perioperative Genotype-Guided Irinotecan Dosing of mFOLFIRINOX for Locally Advanced Gastroesophageal Adenocarcinoma Recruiting NCT02366819 Phase 4 Oxaliplatin;Leucovorin Calcium;Irinotecan Hydrochloride;Fluorouracil
46 A Multicenter Phase 4 Geriatric Assessment Directed Trial to Evaluate Gemcitabine +/- Nab-paclitaxel in Elderly Pancreatic Cancer Patients Recruiting NCT02812992 Phase 4 Nab-paclitaxel;Gemcitabine
47 Efficacy of Zinc L-carnosine (Hepilor®) in Maintaining Remission of Gastroesophageal Reflux Disease: a Randomised, Double-blind, Placebo-controlled Study Recruiting NCT03467438 Phase 4 Zinc-l-carnosine
48 A Scientific Evaluation of One or Two Doses of Vaccine Against Human Papillomavirus: the ESCUDDO Study Recruiting NCT03180034 Phase 4
49 A Phase IV, Randomized, Double-Blind, Placebo-Controlled, Single-Center Study of the Effects of Fesoterodine in Men at High Risk for Overactive Bladder/Detrusor Overactivity Post Robotic-Assisted Laparoscopic Prostatectomy ) Active, not recruiting NCT01661166 Phase 4 Fesoterodine
50 A Dose Escalation Safety Study of Locally-Delivered (Intra-Arterial) Gemcitabine in Unresectable Adenocarcinoma of the Pancreas Active, not recruiting NCT02237157 Phase 4 Gemcitabine, local delivery

Search NIH Clinical Center for Adenocarcinoma

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Thiotepa

Cochrane evidence based reviews: adenocarcinoma

Genetic Tests for Adenocarcinoma

Anatomical Context for Adenocarcinoma

MalaCards organs/tissues related to Adenocarcinoma:

41
Lung, Prostate, Colon, Pancreas, Breast, Cervix, Lymph Node

Publications for Adenocarcinoma

Articles related to Adenocarcinoma:

(show top 50) (show all 55499)
# Title Authors PMID Year
1
Role of CDK8 and beta-catenin in colorectal adenocarcinoma. 9 38
20514474 2010
2
Expression of RACK1 is a novel biomarker in pulmonary adenocarcinomas. 9 38
19892429 2010
3
ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. 9 38
20031160 2010
4
Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma. 9 38
19949912 2010
5
A novel clinically relevant animal model for studying galectin-3 and its ligands during colon carcinogenesis. 9 38
20197492 2010
6
Overexpression of FADD enhances 5-fluorouracil-induced apoptosis in colorectal adenocarcinoma cells. 9 38
19415536 2010
7
Gene amplification of ERBB2 and EGFR in adenocarcinoma in situ and intramucosal adenocarcinoma of Barrett's esophagus. 9 38
20518902 2010
8
The impact of expressions of CD97 and its ligand CD55 at the invasion front on prognosis of rectal adenocarcinoma. 9 38
20339853 2010
9
Genetic evolution of epidermal growth factor receptor in adenocarcinoma with a bronchioloalveolar carcinoma component. 9 38
20439191 2010
10
Could recombinant insulin compounds contribute to adenocarcinoma progression by stimulating local angiogenesis? 9 38
20182859 2010
11
Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology. 9 38
19856421 2010
12
Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer. 9 38
20372850 2010
13
A study of immunohistochemical differential expression in pulmonary and mammary carcinomas. 9 38
20173733 2010
14
Identification of gastrointestinal contamination in endoscopic ultrasound-guided pancreatic fine needle aspiration. 9 38
20518405 2010
15
DNA damage detected with gammaH2AX in endometrioid adenocarcinoma cell lines. 9 38
20372780 2010
16
MUC16 expression and risk of adenocarcinoma metastases to peritoneum, pleura, leptomeninges, and brain. 9 38
20090516 2010
17
Temporal proteomic analysis of IGF-1R signalling in MCF-7 breast adenocarcinoma cells. 9 38
20213678 2010
18
Utility of thyroid transcription factor-1 and CDX-2 in determining the primary site of metastatic adenocarcinomas in serous effusions. 9 38
20518411 2010
19
True cytokeratin 8/18 immunohistochemistry is of no use in distinguishing between primary endocervical and endometrial adenocarcinomas in a tissue microarray study. 9 38
20407331 2010
20
Immunohistochemical expression of estrogens and progesterone receptors in carcinoma ex pleomorphic adenoma-undifferentiated and adenocarcinoma types. 9 38
20038908 2010
21
Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN). 9 38
20350215 2010
22
Cyclin D1 immunoreactivity in normal endocervix and diagnostic value in reactive and neoplastic endocervical lesions. 9 38
20062011 2010
23
Thyroid transcription factor 1 expression in ovarian carcinomas is an independent prognostic factor. 9 38
20004952 2010
24
Podoplanin is a useful marker for identifying mesothelioma in malignant effusions. 9 38
20146302 2010
25
Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. 9 38
20154720 2010
26
Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases. 9 38
20377670 2010
27
Diagnostic value and implications of vimentin expression in normal, reactive and neoplastic endocervical epithelium. 9 38
20350213 2010
28
Lymph node involvement and not the histophatologic subtype is correlated with outcome after resection of adenocarcinoma of the ampulla of vater. 9 38
20107918 2010
29
Immunohistochemical detection of receptor tyrosine kinases c-kit, EGF-R, and PDGF-R in colorectal adenocarcinomas. 9 38
19280218 2010
30
Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder. 9 38
20040392 2010
31
Microcystic adenocarcinoma of the prostate: a variant of pseudohyperplastic and atrophic patterns. 9 38
20216381 2010
32
Integration of biomarkers including molecular targeted therapies in head and neck cancer. 9 38
20237991 2010
33
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Variations for Adenocarcinoma

ClinVar genetic disease variations for Adenocarcinoma:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 TP53 NM_000546.5(TP53): c.733G> A (p.Gly245Ser) single nucleotide variant Pathogenic rs28934575 17:7577548-7577548 17:7674230-7674230

Copy number variations for Adenocarcinoma from CNVD:

7 (show all 49)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 25149 1 184907591 184916179 Amplification PTGS2 Adenocarcinoma
2 33704 1 47467454 47552406 Amplification STIL Adenocarcinoma
3 66093 12 25249446 25295130 Amplification KRAS Adenocarcinoma
4 66576 12 3100000 5300000 Gain LOC399986 Adenocarcinoma
5 66578 12 3100000 5300000 Gain LOC441627 Adenocarcinoma
6 66580 12 3100000 5300000 Gain TSPAN9 Adenocarcinoma
7 74649 13 109973413 110012072 Amplification RAB20 Adenocarcinoma
8 87573 14 74815283 74818665 Amplification FOS Adenocarcinoma
9 93655 15 57100000 61500000 Loss RORA Adenocarcinoma
10 95696 15 79500000 83000000 Loss DNM1DN11-6 Adenocarcinoma
11 95698 15 79500000 83000000 Loss LOC159170 Adenocarcinoma
12 95700 15 79500000 83000000 Loss LOC161527 Adenocarcinoma
13 95702 15 79500000 83000000 Loss LOC388152 Adenocarcinoma
14 95704 15 79500000 83000000 Loss LOC388160 Adenocarcinoma
15 95706 15 79500000 83000000 Loss LOC440300 Adenocarcinoma
16 95708 15 79500000 83000000 Loss LOC440301 Adenocarcinoma
17 97921 16 14700000 16700000 Loss Adenocarcinoma
18 107538 17 15900000 22100000 Loss Adenocarcinoma
19 111139 17 35097918 35138441 Amplification ERBB2 Adenocarcinoma
20 123836 18 89115825 89123587 Amplification SPP1 Adenocarcinoma
21 135625 2 118600000 122100000 Gain Adenocarcinoma
22 171545 3 169200000 172500000 Gain EVI1 Adenocarcinoma
23 171548 3 169200000 172500000 Gain LOC389174 Adenocarcinoma
24 171550 3 169200000 172500000 Gain MDS1 Adenocarcinoma
25 172147 3 177300000 180600000 Gain KCNMB3 Adenocarcinoma
26 172149 3 177300000 180600000 Gain PIK3CA Adenocarcinoma
27 172225 3 178866310 178952497 Gain PIK3CA Adenocarcinoma
28 172903 3 187500000 189400000 Gain MASP1 Adenocarcinoma
29 173068 3 189400000 193800000 Gain FGF12 Adenocarcinoma
30 173072 3 189400000 193800000 Gain TP73L Adenocarcinoma
31 173431 3 193800000 199501827 Gain KIAA0226 Adenocarcinoma
32 173434 3 193800000 199501827 Gain LOC220729 Adenocarcinoma
33 173436 3 193800000 199501827 Gain LOC440996 Adenocarcinoma
34 173438 3 193800000 199501827 Gain LOC440997 Adenocarcinoma
35 173440 3 193800000 199501827 Gain LOC440998 Adenocarcinoma
36 173442 3 193800000 199501827 Gain OPA1 Adenocarcinoma
37 206066 6 135544145 135582003 Amplification MYB Adenocarcinoma
38 218057 7 107200000 137300000 Amplification Adenocarcinoma
39 218695 7 116312458 116438439 Copy number MET Adenocarcinoma
40 225387 7 45400000 54000000 Copy number EGFR Adenocarcinoma
41 226106 7 55054218 55242525 Amplification EGFR Adenocarcinoma
42 230093 7 97900000 104400000 Gain TRRAP Adenocarcinoma
43 230096 7 97900000 104400000 Gain ZKSCAN1 Adenocarcinoma
44 230097 7 97900000 104400000 Gain ZNF3 Adenocarcinoma
45 230098 7 97900000 104400000 Gain ZNF38 Adenocarcinoma
46 233908 8 128816946 128822855 Amplification MYC Adenocarcinoma
47 239383 8 38973661 39081936 Amplification ADAM9 Adenocarcinoma
48 240761 8 55041668 55097561 Translate TCEA1 Adenocarcinoma
49 241225 8 59800000 146274826 Copy number Adenocarcinoma

Expression for Adenocarcinoma

Search GEO for disease gene expression data for Adenocarcinoma.

Pathways for Adenocarcinoma

Pathways related to Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.34 TP53 TGFBR2 SMAD4 PIK3CA KRAS HRAS
2
Show member pathways
14.01 TP53 RB1 KRAS HRAS ERBB4 ERBB2
3
Show member pathways
14.01 TP53 TGFBR2 SMAD4 RB1 KRAS HRAS
4
Show member pathways
13.9 TP53 TGFBR2 SMAD4 RB1 KRAS HRAS
5
Show member pathways
13.89 TGFBR2 SMAD4 PIK3CA KRAS HRAS ERBB4
6
Show member pathways
13.84 TP53 TGFBR2 SMAD4 KRAS HRAS ERBB4
7
Show member pathways
13.73 TGFBR2 SMAD4 KRAS HRAS ERBB4 ERBB2
8
Show member pathways
13.73 TP53 TGFBR2 SMAD4 PIK3CA KRAS HRAS
9
Show member pathways
13.68 SMAD4 PIK3CA KRAS HRAS ERBB4 ERBB2
10
Show member pathways
13.62 TP53 PIK3CA KRAS HRAS ERBB4 ERBB2
11
Show member pathways
13.55 TGFBR2 PIK3CA KRAS HRAS EGFR CTNNB1
12
Show member pathways
13.54 TP53 PIK3CA KRAS HRAS ERBB4 ERBB2
13
Show member pathways
13.48 TGFBR2 SMAD4 KRAS HRAS ERBB2 EGFR
14
Show member pathways
13.47 KRAS HRAS ERBB4 ERBB2 EGFR CTNNB1
15
Show member pathways
13.38 TP53 KRAS HRAS ERBB4 ERBB2 EGFR
16
Show member pathways
13.2 TP53 KRAS HRAS EGFR BRAF AKT1
17
Show member pathways
13.2 KRAS HRAS EGFR CTNNB1 CDKN2A BRAF
18
Show member pathways
13.2 TP53 RB1 PIK3CA KRAS HRAS ERBB4
19
Show member pathways
13.19 TP53 KRAS HRAS CTNNB1 CDH1 BRAF
20
Show member pathways
13.17 TGFBR2 PIK3CA KRAS HRAS EGFR AKT1
21
Show member pathways
13.17 TP53 SMAD4 RB1 PIK3CA KRAS HRAS
22
Show member pathways
13.15 TP53 RB1 PIK3CA KRAS HRAS EGFR
23
Show member pathways
13.12 RB1 PIK3CA KRAS HRAS ERBB2 EGFR
24
Show member pathways
13.11 TGFBR2 PIK3CA KRAS HRAS ERBB2 EGFR
25
Show member pathways
13.1 TP53 PIK3CA KRAS HRAS EGFR BRAF
26
Show member pathways
13.1 TGFBR2 KRAS HRAS CTNNB1 CDH1 BRAF
27
Show member pathways
13.07 TGFBR2 PIK3CA KRAS HRAS ERBB4 ERBB2
28
Show member pathways
12.98 TP53 PIK3CA KRAS HRAS CDKN2A AKT1
29 12.98 TP53 TGFBR2 KRAS HRAS ERBB4 ERBB2
30
Show member pathways
12.95 PIK3CA KRAS HRAS EGFR CTNNB1 CDH1
31
Show member pathways
12.95 TP53 PIK3CA KRAS HRAS ERBB4 ERBB2