MCID: ADN017
MIFTS: 35

Adenofibroma

Categories: Cancer diseases

Aliases & Classifications for Adenofibroma

MalaCards integrated aliases for Adenofibroma:

Name: Adenofibroma 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2683
MeSH 43 D000232
SNOMED-CT 67 2962009
UMLS 71 C0001422

Summaries for Adenofibroma

Disease Ontology : 12 A cell type benign neoplasm that is composed of glandular and fibrous tissues, with a relatively large proportion of glands.

MalaCards based summary : Adenofibroma is related to clear cell adenofibroma and ovarian serous adenofibroma. An important gene associated with Adenofibroma is CALB2 (Calbindin 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Interleukin-4 and 13 signaling. Affiliated tissues include ovary, breast and uterus, and related phenotypes are cardiovascular system and cellular

Related Diseases for Adenofibroma

Diseases in the Adenofibroma family:

Malignant Adenofibroma

Diseases related to Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 450)
# Related Disease Score Top Affiliating Genes
1 clear cell adenofibroma 34.1 NAPSA ARID1A
2 ovarian serous adenofibroma 33.7 TP53 KRT7 CALB2
3 nephrogenic adenofibroma 33.5 WT1 KRT7
4 ovarian serous cystadenofibroma 31.4 TP53 MUC1 KRT7 INHA CALB2
5 adenosarcoma 30.7 VIM TP53 MME ACTC1
6 clear cell cystadenofibroma 30.6 TP53 CALB2
7 myoma 30.2 TP53 MUC16 MME
8 biphasic synovial sarcoma 30.2 VIM PAX8 MUC1
9 adenoma 30.1 TP53 MUC1 KRT7 BRAF
10 ovarian clear cell adenocarcinoma 30.0 TP53 NAPSA ARID1A
11 spindle cell sarcoma 30.0 VIM MUC1 KRT7 ACTC1
12 epithelial predominant wilms' tumor 29.9 WT1 KRT7
13 endometrial adenocarcinoma 29.8 VIM TP53 MUC1 KRT7
14 nephroma 29.8 WT1 MUC1 MME KRT19 ACTC1
15 intrahepatic cholangiocarcinoma 29.7 TP53 MUC1 KRT7 KRT19 ARID1A
16 adenocarcinoma 29.7 TP53 NAPSA MUC1 KRT7 BRAF
17 cystadenoma 29.6 MUC16 MUC1 MME KRT7 INHA CALB2
18 endometrial stromal sarcoma 29.5 VIM TP53 MME INHA ACTC1
19 cholangiocarcinoma 29.5 TP53 MUC1 MME KRT7 KRT19 BRAF
20 metanephric adenoma 29.5 WT1 VIM MUC1 KRT7 BRAF
21 collecting duct carcinoma 29.2 VIM PAX8 MUC1 MME KRT7 KRT19
22 papillary adenocarcinoma 29.2 VIM TP53 MUC16 MUC1 KRT7 KRT19
23 thyroid gland cancer 29.2 TP53 PAX8 KRT7 KRT19 BRAF
24 benign mesothelioma 29.2 WT1 PAX8 KRT7 CALB2
25 clear cell adenocarcinoma 29.1 TP53 PAX8 NAPSA MUC16 KRT7 ARID1A
26 sarcoma, synovial 29.1 WT1 VIM MUC1 KRT7 KRT19 CALB2
27 ovarian clear cell carcinoma 29.0 TP53 NAPSA MUC16 KRT7 ARID1A
28 sarcoma 28.8 WT1 VIM TP53 MUC1 BRAF ACTC1
29 ovarian serous cystadenocarcinoma 28.7 TP53 PAX8 MUC16 MUC1 CALB2 BRAF
30 wilms tumor 1 28.6 WT1 TP53 PAX8 KRT7 CALB2
31 cystadenofibroma 28.5 WT1 PAX8 MUC16 MUC1 MME KRT7
32 renal cell carcinoma, papillary, 1 28.3 WT1 TP53 PAX8 MME KRT7 KRT19
33 endometrial cancer 26.9 WT1 TP53 PAX8 MUC16 MUC1 MME
34 renal cell carcinoma, nonpapillary 26.3 WT1 VIM TP53 PAX8 NAPSA MUC1
35 papillary adenofibroma 12.6
36 mucinous adenofibroma 12.6
37 cervical adenofibroma 12.3
38 ovarian clear cell adenofibroma 12.3
39 ovarian endometrioid adenofibroma 12.3
40 fallopian tube adenofibroma 12.3
41 ovarian mucinous adenofibroma 12.3
42 malignant adenofibroma 12.2
43 giant adenofibroma of the breast 12.2
44 uterine corpus adenofibroma 12.2
45 ovarian mucinous malignant adenofibroma 12.1
46 ovarian endometrioid malignant adenofibroma 12.1
47 ovarian clear cell malignant adenofibroma 12.1
48 ovarian clear cell cystadenofibroma 11.2
49 ovarian mucinous cystadenofibroma 11.2
50 ovarian endometrioid cystadenofibroma 11.2

Graphical network of the top 20 diseases related to Adenofibroma:



Diseases related to Adenofibroma

Symptoms & Phenotypes for Adenofibroma

MGI Mouse Phenotypes related to Adenofibroma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ACTC1 ARID1A BRAF INHA KRT19 PAX8
2 cellular MP:0005384 9.85 ACTC1 ARID1A BRAF KRT19 KRT7 MME
3 neoplasm MP:0002006 9.43 ARID1A BRAF INHA KRT19 TP53 WT1
4 normal MP:0002873 9.28 ACTC1 ARID1A BRAF CALB2 INHA KRT19

Drugs & Therapeutics for Adenofibroma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Renal Tumors Classification, Biology, and Banking Study Suspended NCT00898365

Search NIH Clinical Center for Adenofibroma

Cochrane evidence based reviews: adenofibroma

Genetic Tests for Adenofibroma

Anatomical Context for Adenofibroma

MalaCards organs/tissues related to Adenofibroma:

40
Ovary, Breast, Uterus, Cervix, Kidney, Liver, Lung

Publications for Adenofibroma

Articles related to Adenofibroma:

(show top 50) (show all 319)
# Title Authors PMID Year
1
Ovarian carcinomas, including secondary tumors: diagnostically challenging areas. 54 61
15492758 2005
2
Significant increases in serum CA125 and CA19-9 following torsion from an adenofibroma of the ovary: a case report. 54 61
8158859 1994
3
Giant serous adenofibroma of the fallopian tube. 61
32522722 2020
4
Prominent entrapment of respiratory epithelium in primary and metastatic intrapulmonary non-epithelial neoplasms: a frequent morphological pattern closely mimicking adenofibroma and other biphasic pulmonary lesions. 61
32193604 2020
5
Papillary Cystadenofibroma of Fallopian Tube: Case Report with a Literature Review. 61
32317841 2020
6
Pathology of the Fallopian Tube: Tubal Involvement by Ovarian Tumors and Incidental Findings in the Nontumoral Setting. 61
31972564 2020
7
Magnetic Resonance Imaging Findings of Biliary Adenofibroma. 61
31870142 2019
8
A case of biliary adenofibroma of the liver with malignant transformation: a morphomolecular case report and review of the literature. 61
31236706 2019
9
Pitfalls of Frozen Section in Gynecological Pathology: A Case of Ovarian Serous Surface Papillary Adenofibroma Imitating Malignancy. 61
30563377 2019
10
Synchronous Pulmonary Adenofibroma and Solitary Fibrous Tumor: Case Report and Review of the Literature. 61
30360665 2019
11
Pulmonary adenofibroma in a sika deer. 61
30726785 2019
12
[Biliary adenofibroma of liver: report of a case]. 61
30695873 2019
13
Glucocorticoid resistance syndrome caused by a novel NR3C1 point mutation. 61
30158362 2018
14
Malignant Transformation Arising Within Unusual and Rare Hepatic Lesions: Fibropolycystic Disease Form of Ductal Plate Malformation and Biliary Adenofibroma. 61
29464972 2018
15
Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma. 61
29551085 2018
16
Genetic analysis and phosphoinositide 3-kinase/protein kinase B signaling pathway status in ovarian endometrioid borderline tumor samples. 61
29928400 2018
17
An "accidental" discovery: Incidentally found metanephric adenofibroma in a 5-year-old male trauma patient. 61
30026886 2018
18
Endoscopic papillectomy of benign ampullary lesions: Outcomes from a multicenter study. 61
29755017 2018
19
Uncommon Human Telomerase Reverse Transcriptase Promoter Mutations Are Associated With Poor Survival in Ovarian Clear Cell Carcinoma. 61
29474637 2018
20
A case of a primary hepatic so-called adenosarcoma with heterotopic ossification: possibly of biliary adenofibroma origin. 61
29079182 2018
21
Microscopic Heterotopic Extraovarian Sex Cord-Stromal Proliferations: Expanding the Histologic Spectrum. 61
28319576 2018
22
Double Trouble: A Rare Case of Concurrent Biliary Adenofibroma and Hepatobiliary Mucinous Cystic Neoplasm. 61
30370311 2018
23
Magnetic Resonance Imaging and Flexible Hysterofiberscopic Findings of a Uterine Adenofibroma: Case Report and Literature Review. 61
29670786 2018
24
[Radio-histological correlation of ACR4 microcalcifications in breast lesions: about 181 cases and literature review]. 61
30050604 2018
25
[A rare pulmonary benign bi-phasic tumor: a case report of pulmonary adenofibroma and literature review]. 61
29263485 2017
26
Solitary pulmonary adenofibroma in a middle-aged man with bladder cancer. 61
29099009 2017
27
Prognostic impact of interleukin-6 expression in stage I ovarian clear cell carcinoma. 61
28673661 2017
28
Eosinophilic Cells, Autoimplants, Degree of Cellular Proliferation, and Adenofibroma Pattern are Important Histologic Findings in Ovarian Borderline Tumors. 61
28796659 2017
29
Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome. 61
28288139 2017
30
Metanephric Adenofibroma In A Young Adult. 61
27802007 2017
31
Biliary Adenofibroma of Liver: Morphology, Tumor Genetics, and Outcomes in 6 Cases. 61
28266931 2017
32
Uterine Adenofibroma: An Unsual Cause of Nonpuerperal Uterine Inversion in Postmenopausal Female. 61
28706412 2017
33
Possible de novo clear cell carcinoma in the contralateral ovary 9 years after fertility-sparing surgery for Stage IA clear cell ovarian carcinoma. 61
31149470 2017
34
Effects of long-term construction noise on health of adult female Wistar rats. 61
28525342 2017
35
Adenofibroma in the Uterine Cervix Manifesting as Multilocular Cystic Lesions. 61
28081019 2017
36
Mature cystic teratoma coexisting with clear-cell carcinoma in the ovary. 61
27987343 2017
37
BRAF exon 15 mutations in pediatric renal stromal tumors: prevalence in metanephric stromal tumors. 61
27769870 2017
38
Biliary adenofibroma: A rare hepatic lesion with malignant features. 61
27631648 2017
39
Primary Neuroendocrine Breast Carcinoma in a 13-Year-Old Girl: Ultrasonography and Pathology Findings. 61
29082059 2017
40
Borderline Clear Cell Adenofibroma of the Ovary. 61
28465851 2017
41
Malignant transformation of biliary adenofibroma: a rare biliary cystic tumor. 61
28078134 2016
42
Pulmonary Adenofibroma: Report of a Case with Multiple Masses. 61
27993885 2016
43
Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes. 61
27167231 2016
44
Metanephric Adenofibroma Masquerading as Wilms' Tumor. 61
27900278 2016
45
Yolk sac tumours of the female genital tract in older adults derive commonly from somatic epithelial neoplasms: somatically derived yolk sac tumours. 61
27334714 2016
46
Endometrial Endometrioid Carcinoma With Large Cystic Growth Configuration and Deceptive Pattern of Invasion Associated With Abundant Nodular Fasciitis-like Stroma: A Unique Hitherto Unreported Histology in Endometrioid Carcinoma. 61
27740962 2016
47
Effect of ARID1A/BAF250a expression on carcinogenesis and clinicopathological factors in pure-type clear cell adenocarcinoma of the ovary. 61
27699033 2016
48
Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome. 61
27340747 2016
49
[Plumonary adenofibroma: report of a case]. 61
27646899 2016
50
A case of biliary adenofibroma with malignant transformation. 61
26778388 2016

Variations for Adenofibroma

Expression for Adenofibroma

Search GEO for disease gene expression data for Adenofibroma.

Pathways for Adenofibroma

Pathways related to Adenofibroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 VIM MUC1 KRT7 KRT19 ACTC1
2 11.49 VIM TP53 MUC1
3
Show member pathways
11.37 VIM KRT7 KRT19
4 11 WT1 VIM MME

GO Terms for Adenofibroma

Cellular components related to Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.23 VIM NAPSA MUC16 MUC1 MME KRT7

Biological processes related to Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.65 WT1 VIM TP53 BRAF ACTC1
2 kidney development GO:0001822 9.61 WT1 PAX8 MME
3 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.4 TP53 MUC1
4 replicative senescence GO:0090399 9.37 TP53 MME
5 cellular response to gonadotropin stimulus GO:0071371 9.32 WT1 PAX8
6 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.16 TP53 MUC1
7 metanephric S-shaped body morphogenesis GO:0072284 8.96 WT1 PAX8
8 metanephric epithelium development GO:0072207 8.62 WT1 PAX8

Sources for Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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