MCID: ADN017
MIFTS: 36

Adenofibroma

Categories: Cancer diseases
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Aliases & Classifications for Adenofibroma

MalaCards integrated aliases for Adenofibroma:

Name: Adenofibroma 11 53 43 14 16 71

Classifications:



External Ids:

Disease Ontology 11 DOID:2683
MeSH 43 D000232
SNOMED-CT 68 189823009
UMLS 71 C0001422

Summaries for Adenofibroma

Disease Ontology: 11 A cell type benign neoplasm that is composed of glandular and fibrous tissues, with a relatively large proportion of glands.

MalaCards based summary: Adenofibroma is related to clear cell adenofibroma and nephrogenic adenofibroma. An important gene associated with Adenofibroma is CALB2 (Calbindin 2), and among its related pathways/superpathways are Development EGFR signaling pathway and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Affiliated tissues include ovary, uterus and breast, and related phenotypes are normal and nervous system

Related Diseases for Adenofibroma

Diseases in the Adenofibroma family:

Malignant Adenofibroma

Diseases related to Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 496)
# Related Disease Score Top Affiliating Genes
1 clear cell adenofibroma 32.2 NAPSA ARID1A
2 nephrogenic adenofibroma 32.1 WT1 KRT7
3 ovarian serous adenofibroma 31.8 TP53 PAX8 CALB2
4 papillary adenofibroma 31.4 WT1 PAX8 NAPSA CALB2 ARID1A
5 ovarian serous cystadenofibroma 30.6 WT1 TP53 PAX8 KRT7 CALB2
6 adenosarcoma 30.6 VIM TP53 MME
7 wilms tumor 5 30.4 WT1 PAX8 BRAF
8 nephroma 30.1 WT1 VIM MME ACTC1
9 biphasic synovial sarcoma 30.0 KRT7 CALB2
10 collecting duct carcinoma 30.0 PAX8 MME KRT7
11 clear cell cystadenofibroma 30.0 TP53 CALB2
12 epithelial predominant wilms' tumor 29.9 WT1 KRT7
13 metanephric adenoma 29.8 WT1 PAX8 MME KRT7
14 cystadenoma 29.6 MUC16 MUC1 MME KRT7 INHA CALB2
15 lung benign neoplasm 29.6 TP53 KRT7 KRAS
16 bile duct cystadenoma 29.6 TP53 KRT7 KRT19
17 benign mesothelioma 29.5 WT1 KRT7 KRT19 CALB2
18 blastoma 29.5 TP53 KRT7 KRAS
19 breast ductal carcinoma 29.4 TP53 MUC1 KRT7 KRT19
20 sarcoma, synovial 29.4 WT1 VIM MUC1 KRT7 KRT19 CALB2
21 endometrial hyperplasia 29.4 TP53 KRAS ARID1A
22 pulmonary blastoma 29.2 TP53 MUC1 KRAS ACTC1
23 clear cell adenocarcinoma 29.0 TP53 PAX8 NAPSA MUC16 MME KRT7
24 cholangiocarcinoma 29.0 TP53 MUC1 MME KRT7 KRT19 KRAS
25 myoma 29.0 TP53 MME KRAS CALB2 ACTC1
26 intrahepatic cholangiocarcinoma 29.0 TP53 KRT7 KRT19 KRAS ARID1A
27 fallopian tube carcinoma 28.9 WT1 TP53 PAX8 KRT7 CALB2
28 endometrial adenocarcinoma 28.9 TP53 PAX8 KRT7 KRAS
29 adenocarcinoma 28.8 TP53 NAPSA MUC1 KRT7 KRAS BRAF
30 endometrial stromal sarcoma 28.8 WT1 VIM TP53 MME INHA CALB2
31 cystadenofibroma 28.8 WT1 TP53 PAX8 MME KRT7 KRAS
32 bladder cancer 28.6 TP53 MUC1 KRT7 KRT19 KRAS BRAF
33 sarcoma 28.6 WT1 VIM TP53 MUC1 KRAS CALB2
34 ovarian serous cystadenocarcinoma 28.6 TP53 PAX8 MUC16 MUC1 KRAS BRAF
35 ovarian clear cell carcinoma 28.5 WT1 TP53 NAPSA KRAS ARID1A
36 wilms tumor 1 28.4 WT1 TP53 PAX8 MUC1 MME KRT7
37 mixed cell type cancer 28.4 WT1 TP53 PAX8 MME KRT7 KRAS
38 papillary serous adenocarcinoma 28.3 WT1 TP53 PAX8 KRT7 KRAS CALB2
39 renal cell carcinoma, papillary, 1 28.3 WT1 TP53 PAX8 MME KRT7 KRAS
40 carcinosarcoma 28.3 WT1 VIM TP53 PAX8 MUC1 MME
41 ovary adenocarcinoma 28.2 WT1 TP53 PAX8 MUC16 MUC1 KRT7
42 papillary adenocarcinoma 28.1 TP53 PAX8 NAPSA MUC16 MUC1 KRT7
43 endometrial cancer 27.8 WT1 TP53 MUC16 MUC1 MME KRT7
44 ovarian cancer 27.8 WT1 VIM TP53 MUC16 MUC1 KRT7
45 serous cystadenocarcinoma 27.6 WT1 TP53 PAX8 NAPSA MUC16 KRT7
46 renal cell carcinoma, nonpapillary 26.4 WT1 VIM TP53 PAX8 NAPSA MUC1
47 mucinous adenofibroma 11.4
48 giant adenofibroma of the breast 11.2
49 uterine corpus adenofibroma 11.2
50 ovarian clear cell adenofibroma 11.2

Graphical network of the top 20 diseases related to Adenofibroma:



Diseases related to Adenofibroma

Symptoms & Phenotypes for Adenofibroma

MGI Mouse Phenotypes related to Adenofibroma:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 10.27 ACTC1 ARID1A BRAF CALB2 INHA KRAS
2 nervous system MP:0003631 10.16 ACTC1 ARID1A BRAF CALB2 KRAS KRT19
3 homeostasis/metabolism MP:0005376 10.15 ACTC1 ARID1A BRAF INHA KRAS KRT7
4 neoplasm MP:0002006 10.11 ARID1A BRAF INHA KRAS KRT19 MUC1
5 no phenotypic analysis MP:0003012 10.02 ARID1A KRAS KRT19 MUC1 PAX8 TP53
6 liver/biliary system MP:0005370 10.01 BRAF INHA KRAS KRT19 MME MUC1
7 muscle MP:0005369 9.98 ACTC1 ARID1A BRAF KRAS TP53 VIM
8 endocrine/exocrine gland MP:0005379 9.97 ARID1A BRAF INHA KRAS KRT19 MUC1
9 cellular MP:0005384 9.93 ACTC1 ARID1A BRAF INHA KRAS KRT19
10 embryo MP:0005380 9.86 ARID1A BRAF KRAS KRT19 PAX8 TP53
11 cardiovascular system MP:0005385 9.65 ACTC1 ARID1A BRAF INHA KRAS KRT19
12 reproductive system MP:0005389 9.32 ARID1A BRAF INHA KRAS KRT19 MUC16

Drugs & Therapeutics for Adenofibroma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Renal Tumors Classification, Biology, and Banking Study Recruiting NCT00898365

Search NIH Clinical Center for Adenofibroma

Cochrane evidence based reviews: adenofibroma

Genetic Tests for Adenofibroma

Anatomical Context for Adenofibroma

Organs/tissues related to Adenofibroma:

MalaCards : Ovary, Uterus, Breast, Cervix, Salivary Gland, Liver, Testis

Publications for Adenofibroma

Articles related to Adenofibroma:

(show top 50) (show all 343)
# Title Authors PMID Year
1
Ovarian carcinomas, including secondary tumors: diagnostically challenging areas. 53 62
15492758 2005
2
Significant increases in serum CA125 and CA19-9 following torsion from an adenofibroma of the ovary: a case report. 53 62
8158859 1994
3
MRI imaging presentation of biliary adenofibroma. 62
36473812 2022
4
A Case of Multicystic Biliary Hamartoma with a Marked Peribiliary Gland Component Successfully Treated by Purely Laparoscopic Anatomical Liver Resection. 62
36449146 2022
5
Pulmonary adenofibroma with central liquefaction necrosis: A case report. 62
35949330 2022
6
Malignant transformation of biliary adenofibroma combined with benign lymphadenopathy mimicking advanced liver carcinoma: A case report. 62
36157634 2022
7
Cervical Adenofibroma Found in Congenital Cervical and Vaginal Aplasia After Uterovaginal Anastomosis. 62
36122886 2022
8
Cervical adenofibroma without clinical symptoms: report of a rare case. 62
36168707 2022
9
Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities. 62
35697170 2022
10
Atypical Biliary Adenofibroma of the Liver: Related Treatment and Performance. 62
36157605 2022
11
Imaging features of biliary adenofibroma of the liver with malignant transformation: a case report with literature review. 62
35296268 2022
12
Imaging presentation of biliary adenofibroma: A case report. 62
35211571 2022
13
Biliary Adenofibroma: A Rare Liver Tumor with Transition to Invasive Carcinoma. 62
35178267 2022
14
A case report of adenofibroma arising from the seminal vesicle: A rare giant pelvic mass. 62
36249033 2022
15
Ovarian Clear Cell Tumors Associated With Seromucinous Borderline Tumor: A Case Series. 62
33741765 2022
16
Robotic enucleation of a biliary adenofibroma. 62
34376413 2021
17
[Biliary adenofibroma of the liver with malignant transformation:report of a case]. 62
34405631 2021
18
A Case Report of Cholangiocarcinoma Arising from a Biliary Adenofibroma: Radiologic Findings and Review of Literature. 62
36238782 2021
19
Ovarian seromucinous cystadenomas and adenofibromas: first report of a case series. 62
32810322 2021
20
A Case of Pulmonary Adenofibroma Treated by Thoracoscopic Resection. 62
34980742 2021
21
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation. 62
33186060 2021
22
Pulmonary Adenofibroma: Clinicopathological and Genetic Analysis of 7 Cases With Literature Review. 62
34350112 2021
23
Prominent entrapment of respiratory epithelium in primary and metastatic intrapulmonary non-epithelial neoplasms: a frequent morphological pattern closely mimicking adenofibroma and other biphasic pulmonary lesions. 62
32193604 2020
24
Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours. 62
32698852 2020
25
Giant serous adenofibroma of the fallopian tube. 62
32522722 2020
26
Pulmonary Adenofibroma Manifesting as Two Nodules in Different Lobes of the Lung: A Case Report. 62
36237385 2020
27
Papillary Cystadenofibroma of Fallopian Tube: Case Report with a Literature Review. 62
32317841 2020
28
Imaging Features of Carcinosarcoma Arising from Adenofibroma of the Uterus: A Case Report. 62
33081666 2020
29
Pathology of the Fallopian Tube: Tubal Involvement by Ovarian Tumors and Incidental Findings in the Nontumoral Setting. 62
31972564 2020
30
Magnetic Resonance Imaging Findings of Biliary Adenofibroma. 62
31870142 2019
31
A case of biliary adenofibroma of the liver with malignant transformation: a morphomolecular case report and review of the literature. 62
31236706 2019
32
Pitfalls of Frozen Section in Gynecological Pathology: A Case of Ovarian Serous Surface Papillary Adenofibroma Imitating Malignancy. 62
30563377 2019
33
Synchronous Pulmonary Adenofibroma and Solitary Fibrous Tumor: Case Report and Review of the Literature. 62
30360665 2019
34
Pulmonary adenofibroma in a sika deer. 62
30726785 2019
35
[Biliary adenofibroma of liver: report of a case]. 62
30695873 2019
36
Glucocorticoid resistance syndrome caused by a novel NR3C1 point mutation. 62
30158362 2018
37
Malignant Transformation Arising Within Unusual and Rare Hepatic Lesions: Fibropolycystic Disease Form of Ductal Plate Malformation and Biliary Adenofibroma. 62
29464972 2018
38
Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma. 62
29551085 2018
39
Genetic analysis and phosphoinositide 3-kinase/protein kinase B signaling pathway status in ovarian endometrioid borderline tumor samples. 62
29928400 2018
40
An "accidental" discovery: Incidentally found metanephric adenofibroma in a 5-year-old male trauma patient. 62
30026886 2018
41
Endoscopic papillectomy of benign ampullary lesions: Outcomes from a multicenter study. 62
29755017 2018
42
A case of a primary hepatic so-called adenosarcoma with heterotopic ossification: possibly of biliary adenofibroma origin. 62
29079182 2018
43
Uncommon Human Telomerase Reverse Transcriptase Promoter Mutations Are Associated With Poor Survival in Ovarian Clear Cell Carcinoma. 62
29474637 2018
44
Microscopic Heterotopic Extraovarian Sex Cord-Stromal Proliferations: Expanding the Histologic Spectrum. 62
28319576 2018
45
Magnetic Resonance Imaging and Flexible Hysterofiberscopic Findings of a Uterine Adenofibroma: Case Report and Literature Review. 62
29670786 2018
46
Double Trouble: A Rare Case of Concurrent Biliary Adenofibroma and Hepatobiliary Mucinous Cystic Neoplasm. 62
30370311 2018
47
[Radio-histological correlation of ACR4 microcalcifications in breast lesions: about 181 cases and literature review]. 62
30050604 2018
48
[A rare pulmonary benign bi-phasic tumor: a case report of pulmonary adenofibroma and literature review]. 62
29263485 2017
49
Solitary pulmonary adenofibroma in a middle-aged man with bladder cancer. 62
29099009 2017
50
Prognostic impact of interleukin-6 expression in stage I ovarian clear cell carcinoma. 62
28673661 2017

Variations for Adenofibroma

Expression for Adenofibroma

Search GEO for disease gene expression data for Adenofibroma.

Pathways for Adenofibroma

Pathways related to Adenofibroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.94 TP53 MUC1 KRAS BRAF
2 11.73 WT1 VIM KRT19
3 11.61 VIM TP53 MUC1
4 11.51 VIM MUC1 KRT7 KRT19 ACTC1
5 11.4 TP53 KRAS BRAF
6 11.29 WT1 VIM MME
7 10.73 TP53 KRAS BRAF
8 10.37 TP53 BRAF

GO Terms for Adenofibroma

Biological processes related to Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 9.85 VIM KRT7 KRT19
2 cellular response to gonadotropin stimulus GO:0071371 9.62 WT1 PAX8
3 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.56 TP53 MUC1
4 metanephric S-shaped body morphogenesis GO:0072284 9.46 WT1 PAX8
5 positive regulation of gene expression GO:0010628 9.36 WT1 VIM TP53 KRAS BRAF ACTC1
6 metanephric epithelium development GO:0072207 9.26 WT1 PAX8

Sources for Adenofibroma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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