MCID: ADN064
MIFTS: 39

Adenohypophysitis

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Adenohypophysitis

Summaries for Adenohypophysitis

MalaCards based summary : Adenohypophysitis, also known as anterior pituitary hypophysitis, is related to adenoma and pituitary apoplexy. An important gene associated with Adenohypophysitis is PRL (Prolactin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and JAK-STAT signaling pathway (KEGG). Affiliated tissues include pituitary, thyroid and placenta, and related phenotypes are panhypopituitarism and pallor

Related Diseases for Adenohypophysitis

Diseases related to Adenohypophysitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.1 GH1 POMC PRL
2 pituitary apoplexy 30.0 POMC PRL
3 diabetes insipidus 30.0 POMC PRL
4 lymphocytic hypophysitis 29.9 GH1 POMC
5 hypopituitarism 29.8 GH1 POMC PRL
6 amenorrhea 29.7 POMC PRL TRH
7 insulin-like growth factor i 29.5 GH1 PRL
8 hypothyroidism 29.3 GH1 POMC PRL TRH
9 hypothyroidism, congenital, nongoitrous, 4 29.3 GH1 POMC PRL TRH
10 pituitary gland disease 29.2 GH1 POMC PRL TRH
11 generalized resistance to thyroid hormone 10.2 PRL TRH
12 pituitary adenoma 10.2
13 fibrous dysplasia 10.2 GH1 PRL
14 fibrous dysplasia/mccune-albright syndrome 10.2 GH1 PRL
15 mccune-albright syndrome 10.2 GH1 PRL
16 gigantism 10.1 GH1 PRL
17 pituitary infarct 10.1 POMC PRL
18 tetrahydrobiopterin deficiency 10.1 GH1 PRL
19 chiasmal syndrome 10.1 POMC PRL
20 pituitary adenoma 1, multiple types 10.1 GH1 PRL
21 pituitary carcinoma 10.1 POMC PRL
22 hypothyroidism, central, and testicular enlargement 10.1 PRL TRH
23 sella turcica neoplasm 10.1 POMC PRL
24 tuberculum sellae meningioma 10.1 POMC PRL
25 pituitary stalk interruption syndrome 10.1 GH1 PRL
26 nelson syndrome 10.1 POMC PRL
27 sheehan syndrome 10.1 POMC PRL
28 acth-secreting pituitary adenoma 10.1 POMC PRL
29 abducens nerve disease 10.0 POMC PRL
30 suprasellar meningioma 10.0 POMC TRH
31 diabetes insipidus, neurohypophyseal 10.0 POMC PRL
32 premenstrual tension 10.0 POMC PRL
33 adrenal cortex disease 10.0 POMC PRL
34 hypoadrenalism 10.0 GH1 POMC
35 adrenal rest tumor 10.0 POMC PRL
36 endocrine organ benign neoplasm 10.0 POMC PRL
37 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
38 galactorrhea 9.9
39 aging 9.9
40 rheumatic disease 9.9
41 dermoid cyst 9.9
42 infertility 9.9
43 thyroiditis 9.9
44 hypoglycemia 9.9
45 central congenital hypothyroidism 9.9
46 precocious puberty 9.9
47 gynecomastia 9.9 POMC PRL
48 vernal conjunctivitis 9.9 IL2RA POMC
49 pilonidal sinus 9.9 CD4 IL2RA
50 hyperandrogenism 9.9 POMC PRL

Graphical network of the top 20 diseases related to Adenohypophysitis:



Diseases related to Adenohypophysitis

Symptoms & Phenotypes for Adenohypophysitis

Human phenotypes related to Adenohypophysitis:

60 33 (show all 33)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 panhypopituitarism 60 33 hallmark (90%) Very frequent (99-80%) HP:0000871
2 pallor 60 33 frequent (33%) Frequent (79-30%) HP:0000980
3 headache 60 33 frequent (33%) Frequent (79-30%) HP:0002315
4 blurred vision 60 33 frequent (33%) Frequent (79-30%) HP:0000622
5 secondary growth hormone deficiency 60 33 frequent (33%) Frequent (79-30%) HP:0008240
6 impotence 60 33 frequent (33%) Frequent (79-30%) HP:0000802
7 decreased circulating cortisol level 60 33 frequent (33%) Frequent (79-30%) HP:0008163
8 decreased serum estradiol 60 33 frequent (33%) Frequent (79-30%) HP:0008214
9 orthostatic hypotension 60 33 frequent (33%) Frequent (79-30%) HP:0001278
10 nausea 60 33 frequent (33%) Frequent (79-30%) HP:0002018
11 pituitary hypothyroidism 60 33 frequent (33%) Frequent (79-30%) HP:0008245
12 adrenocorticotropin deficient adrenal insufficiency 60 33 frequent (33%) Frequent (79-30%) HP:0011735
13 adrenocorticotropic hormone deficiency 60 33 frequent (33%) Frequent (79-30%) HP:0011748
14 prolactin excess 60 33 frequent (33%) Frequent (79-30%) HP:0000870
15 amenorrhea 60 33 frequent (33%) Frequent (79-30%) HP:0000141
16 decreased female libido 60 33 frequent (33%) Frequent (79-30%) HP:0030018
17 progressive visual field defects 60 33 frequent (33%) Frequent (79-30%) HP:0007987
18 hyposthenuria 60 33 frequent (33%) Frequent (79-30%) HP:0003158
19 gonadotropin deficiency 60 33 frequent (33%) Frequent (79-30%) HP:0008213
20 abnormal size of pituitary gland 60 33 frequent (33%) Frequent (79-30%) HP:0012504
21 decreased male libido 60 33 frequent (33%) Frequent (79-30%) HP:0040306
22 abnormal thalamic mri signal intensity 60 33 frequent (33%) Frequent (79-30%) HP:0012696
23 normochromic anemia 60 33 frequent (33%) Frequent (79-30%) HP:0001895
24 decreased serum testosterone level 33 frequent (33%) HP:0040171
25 diplopia 60 33 occasional (7.5%) Occasional (29-5%) HP:0000651
26 sensorineural hearing impairment 60 33 occasional (7.5%) Occasional (29-5%) HP:0000407
27 hashimoto thyroiditis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000872
28 hyponatremia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002902
29 poor appetite 60 33 occasional (7.5%) Occasional (29-5%) HP:0004396
30 antinuclear antibody positivity 60 33 occasional (7.5%) Occasional (29-5%) HP:0003493
31 prolactin deficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0008202
32 chronic lymphocytic meningitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0007041
33 decreased testosterone in males 60 Frequent (79-30%)

MGI Mouse Phenotypes related to Adenohypophysitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.02 CD4 IL2RA POMC PRL TRH

Drugs & Therapeutics for Adenohypophysitis

Search Clinical Trials , NIH Clinical Center for Adenohypophysitis

Genetic Tests for Adenohypophysitis

Anatomical Context for Adenohypophysitis

MalaCards organs/tissues related to Adenohypophysitis:

42
Pituitary, Thyroid, Placenta, Heart, Tongue, Cortex, Adrenal Cortex

Publications for Adenohypophysitis

Articles related to Adenohypophysitis:

(show all 47)
# Title Authors Year
1
Ipilimumab-induced Adenohypophysitis and Orbital Apex Syndrome: Importance of Early Diagnosis and Management. ( 29796053 )
2018
2
Post-partum hypoglycemia and hypothermia as first manifestations of lymphocytic adenohypophysitis: A case report. ( 26786534 )
2016
3
Lymphocytic adenohypophysitis. ( 21592417 )
2011
4
Adenohypophysitis in rat pituitary allografts. ( 20586813 )
2010
5
Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy. ( 20807820 )
2010
6
Granulomatous adenohypophysitis after interferon and ribavirin therapy. ( 17490932 )
2007
7
Longitudinal study of patients with idiopathic isolated TSH deficiency: possible progression of pituitary dysfunction in lymphocytic adenohypophysitis. ( 16896268 )
2006
8
Pituitary apoplexy as a consequence of lymphocytic adenohypophysitis in a pregnant woman: a case report. ( 15949237 )
2005
9
Therapy for lymphocytic adenohypophysitis. ( 12636229 )
2003
10
Lymphocytic adenohypophysitis simulating a pituitary adenoma in a pregnant woman. ( 12528294 )
2002
11
Severe lymphocytic adenohypophysitis with selective disappearance of prolactin cells: a histologic, ultrastructural and immunoelectron microscopic study. ( 11515793 )
2001
12
Lymphocytic adenohypophysitis mimicking a pituitary macroadenoma. ( 10926106 )
2000
13
Spontaneous recovery from pathologically confirmed lymphocytic adenohypophysitis with a dramatic reduction of hypophyseal size. ( 10563747 )
1999
14
Lymphocytic adenohypophysitis: skull radiographs and MRI. ( 9541922 )
1998
15
Lymphocytic adenohypophysitis and lymphocytic infundibuloneurohypophysitis. ( 9152609 )
1997
16
Lymphocytic adenohypophysitis and neurohypophysitis. ( 9187559 )
1997
17
Long-term clinical course of two cases of lymphocytic adenohypophysitis. ( 8930533 )
1996
18
Differentiating lymphocytic adenohypophysitis from pituitary adenoma in the peripartum patient. ( 7623353 )
1995
19
Lymphocytic adenohypophysitis: magnetic resonance imaging features of two new cases and a review of the literature. ( 7758238 )
1995
20
Lymphocytic adenohypophysitis: contrast-enhanced MR imaging in five cases. ( 7892490 )
1995
21
Lymphocytic Adenohypophysitis Associated with Rathke's Cleft Cyst. ( 12114815 )
1995
22
Lymphocytic adenohypophysitis with sudden onset of diabetes insipidus in menopausal female--case report. ( 1381061 )
1992
23
Preoperative diagnosis of lymphocytic hypophysitis (adenohypophysitis) unresponsive to short course dexamethasone: case report. ( 1545900 )
1992
24
Lymphocytic adenohypophysitis: an immunohistochemical study. ( 1891758 )
1991
25
Adenohypophysitis associated with sebaceous gland atrophy in a dog. ( 1949513 )
1991
26
Lymphocytic adenohypophysitis presenting as infertility. Case report. ( 2013781 )
1991
27
Lymphocytic adenohypophysitis: a pituitary mass lesion occurring in pregnancy. Proposal for medical treatment. ( 2048602 )
1991
28
[A case of pregnancy-induced lymphocytic adenohypophysitis complicated by postpartum painless thyroiditis]. ( 2070891 )
1991
29
Lymphocytic adenohypophysitis accompanying occlusion of bilateral internal carotid arteries--case report. ( 1699152 )
1990
30
Lymphocytic adenohypophysitis: report of two cases. ( 2700055 )
1989
31
Lymphocytic adenohypophysitis. Report of a case with demonstration of spontaneous tumour regression and a review of the literature. ( 3077051 )
1988
32
Lymphocytic adenohypophysitis in a man. ( 3208233 )
1988
33
A case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement: a possible variant of lymphocytic adenohypophysitis. ( 3215147 )
1988
34
Lymphocytic adenohypophysitis. ( 3278777 )
1988
35
Lymphocytic adenohypophysitis: clinical, radiological, and magnetic resonance imaging characterization. ( 3380286 )
1988
36
Lymphocytic adenohypophysitis causing pituitary mass. ( 3540725 )
1987
37
Lymphocytic adenohypophysitis of pregnancy with complete recovery. ( 3601028 )
1987
38
Lymphoid adenohypophysitis. ( 3739708 )
1986
39
Lymphocytic adenohypophysitis. A review and a case. ( 4017662 )
1985
40
Lymphoid adenohypophysitis with radiologic and clinical findings resembling a pituitary tumor. ( 6810678 )
1982
41
Lymphocytic adenohypophysitis of pregnancy simulating a pituitary adenoma: a distinct pathological entity. Report of two cases. ( 7054413 )
1982
42
Galactorrhea associated with lymphocytic adenohypophysitis. Case report. ( 7195731 )
1981
43
Lymphocytic adenohypophysitis: autoimmune disorder of the pituitary gland. ( 6779608 )
1980
44
Lymphoid adenohypophysitis presenting as a pituitary tumor. ( 7424950 )
1980
45
Chronic adenohypophysitis in a rhesus monkey immunised with extracts of human placenta. ( 4101493 )
1970
46
Allergic adrenalitis and adenohypophysitis: further observations on production and passive transfer. ( 5773150 )
1969
47
Allergic adenohypophysitis: new experimental disease of the pituitary gland. ( 6057291 )
1967

Variations for Adenohypophysitis

Expression for Adenohypophysitis

Search GEO for disease gene expression data for Adenohypophysitis.

Pathways for Adenohypophysitis

GO Terms for Adenohypophysitis

Cellular components related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.96 GH1 PRL
2 secretory granule GO:0030141 8.62 POMC TRH

Biological processes related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.54 CD4 IL2RA POMC
2 cell surface receptor signaling pathway GO:0007166 9.5 CD4 IL2RA PRL
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.46 CD4 GH1
4 positive regulation of T cell proliferation GO:0042102 9.43 CD4 IL2RA
5 response to nutrient levels GO:0031667 9.4 GH1 PRL
6 positive regulation of JAK-STAT cascade GO:0046427 9.26 GH1 PRL
7 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.16 GH1 PRL
8 response to estradiol GO:0032355 8.96 CD4 GH1
9 regulation of signaling receptor activity GO:0010469 8.92 GH1 POMC PRL TRH

Molecular functions related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prolactin receptor binding GO:0005148 8.96 GH1 PRL
2 hormone activity GO:0005179 8.92 GH1 POMC PRL TRH

Sources for Adenohypophysitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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