MCID: ADN064
MIFTS: 34

Adenohypophysitis

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Adenohypophysitis

MalaCards integrated aliases for Adenohypophysitis:

Name: Adenohypophysitis 58
Anterior Pituitary Hypophysitis 58

Classifications:

Orphanet: 58  
Rare endocrine diseases


Summaries for Adenohypophysitis

MalaCards based summary : Adenohypophysitis, also known as anterior pituitary hypophysitis, is related to lymphocytic hypophysitis and hypopituitarism. An important gene associated with Adenohypophysitis is PRL (Prolactin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and JAK-STAT signaling pathway. Affiliated tissues include pituitary, thyroid and eye, and related phenotypes are panhypopituitarism and pallor

Related Diseases for Adenohypophysitis

Diseases related to Adenohypophysitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 lymphocytic hypophysitis 30.2 POMC GH1
2 hypopituitarism 30.0 TRH PRL POMC GH1
3 amenorrhea 30.0 TRH PRL POMC
4 diabetes insipidus 30.0 PRL POMC GH1
5 pituitary tumors 29.9 PRL POMC GH1
6 pituitary adenoma 29.9 TRH PRL POMC GH1
7 graves disease 1 29.8 TRH POMC
8 adenoma 29.7 TRH PRL POMC GH1
9 sheehan syndrome 29.6 TRH PRL POMC
10 hyperprolactinemia 29.5 TRH PRL POMC GH1
11 hypothyroidism 29.5 TRH PRL POMC GH1
12 hypothyroidism, congenital, nongoitrous, 4 29.4 PRL POMC GH1
13 pituitary apoplexy 29.4 PRL POMC GH1
14 hypoglycemia 29.4 PRL POMC GH1
15 goiter 29.3 TRH PRL
16 pituitary hormone deficiency, combined, 2 29.3 TRH PRL POMC GH1
17 pituitary gland disease 29.3 TRH PRL POMC GH1
18 autoimmune disease 10.2
19 pseudohypoparathyroidism 10.2 TRH PRL
20 generalized resistance to thyroid hormone 10.2 TRH PRL
21 lactocele 10.2 TRH PRL
22 mixed cerebral palsy 10.2 TRH PRL
23 hypothyroidism, central, with testicular enlargement 10.1 TRH PRL
24 tuberculum sellae meningioma 10.1 PRL POMC
25 sella turcica neoplasm 10.1 PRL POMC
26 prolactin producing pituitary tumor 10.1 PRL POMC
27 ectopic cushing syndrome 10.1 PRL POMC
28 abducens nerve disease 10.1 PRL POMC
29 benign essential hypertension 10.1 PRL POMC
30 hormone producing pituitary cancer 10.1 PRL POMC
31 nelson syndrome 10.1 PRL POMC
32 gangliocytoma 10.1 PRL POMC
33 steroid inherited metabolic disorder 10.1 PRL POMC
34 fibrous dysplasia 10.1 PRL GH1
35 fibrous dysplasia/mccune-albright syndrome 10.1 PRL GH1
36 mccune-albright syndrome 10.1 PRL GH1
37 pituitary carcinoma 10.1 PRL POMC
38 suppurative thyroiditis 10.1 TRH CD4
39 wissler-fanconi syndrome 10.1 POMC CD4
40 euthyroid sick syndrome 10.1 TRH POMC
41 gigantism 10.1 PRL GH1
42 galactorrhea 10.1
43 thyroiditis 10.1
44 sebaceous gland disease 10.1 PRL POMC
45 arachnoiditis 10.1 POMC CD4
46 sexual disorder 10.1 PRL POMC
47 acth-secreting pituitary adenoma 10.1 PRL POMC
48 growth hormone secreting pituitary adenoma 10.0 PRL POMC
49 trichinosis 10.0 POMC CD4
50 partial third-nerve palsy 10.0 PRL GH1

Graphical network of the top 20 diseases related to Adenohypophysitis:



Diseases related to Adenohypophysitis

Symptoms & Phenotypes for Adenohypophysitis

Human phenotypes related to Adenohypophysitis:

58 31 (show all 34)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 panhypopituitarism 58 31 hallmark (90%) Very frequent (99-80%) HP:0000871
2 pallor 58 31 frequent (33%) Frequent (79-30%) HP:0000980
3 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
4 impotence 58 31 frequent (33%) Frequent (79-30%) HP:0000802
5 orthostatic hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0001278
6 decreased serum estradiol 58 31 frequent (33%) Frequent (79-30%) HP:0008214
7 pituitary hypothyroidism 58 31 frequent (33%) Frequent (79-30%) HP:0008245
8 adrenocorticotropic hormone deficiency 58 31 frequent (33%) Frequent (79-30%) HP:0011748
9 amenorrhea 58 31 frequent (33%) Frequent (79-30%) HP:0000141
10 blurred vision 58 31 frequent (33%) Frequent (79-30%) HP:0000622
11 abnormal thalamic mri signal intensity 58 31 frequent (33%) Frequent (79-30%) HP:0012696
12 secondary growth hormone deficiency 58 31 frequent (33%) Frequent (79-30%) HP:0008240
13 adrenocorticotropin deficient adrenal insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0011735
14 decreased female libido 58 31 frequent (33%) Frequent (79-30%) HP:0030018
15 decreased circulating cortisol level 58 31 frequent (33%) Frequent (79-30%) HP:0008163
16 increased circulating prolactin concentration 58 31 frequent (33%) Frequent (79-30%) HP:0000870
17 progressive visual field defects 58 31 frequent (33%) Frequent (79-30%) HP:0007987
18 gonadotropin deficiency 58 31 frequent (33%) Frequent (79-30%) HP:0008213
19 nausea 58 31 frequent (33%) Frequent (79-30%) HP:0002018
20 abnormal size of pituitary gland 58 31 frequent (33%) Frequent (79-30%) HP:0012504
21 hyposthenuria 58 31 frequent (33%) Frequent (79-30%) HP:0003158
22 normochromic anemia 58 31 frequent (33%) Frequent (79-30%) HP:0001895
23 decreased male libido 58 31 frequent (33%) Frequent (79-30%) HP:0040306
24 decreased serum testosterone level 31 frequent (33%) HP:0040171
25 diplopia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000651
26 sensorineural hearing impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000407
27 hashimoto thyroiditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000872
28 hyponatremia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002902
29 poor appetite 58 31 occasional (7.5%) Occasional (29-5%) HP:0004396
30 antinuclear antibody positivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0003493
31 chronic lymphocytic meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0007041
32 reduced circulating prolactin concentration 31 occasional (7.5%) HP:0008202
33 decreased testosterone in males 58 Frequent (79-30%)
34 prolactin deficiency 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Adenohypophysitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.02 CD4 IL2RA POMC PRL TRH

Drugs & Therapeutics for Adenohypophysitis

Search Clinical Trials , NIH Clinical Center for Adenohypophysitis

Genetic Tests for Adenohypophysitis

Anatomical Context for Adenohypophysitis

MalaCards organs/tissues related to Adenohypophysitis:

40
Pituitary, Thyroid, Eye, Placenta, Adrenal Gland, Skin, Myeloid

Publications for Adenohypophysitis

Articles related to Adenohypophysitis:

(show top 50) (show all 106)
# Title Authors PMID Year
1
A case of isolated hypothalamitis with a literature review and a comparison with autoimmune hypophysitis. 61
32963149 2021
2
Postpartum headache: A broader differential. 61
32718737 2021
3
[Clinical aspects of pregnancy-related lymphocytic hypophysitis]. 61
33202493 2020
4
Anti-pituitary antibodies as a marker of autoimmunity in pituitary glands. 61
33055452 2020
5
Ipilimumab-induced Adenohypophysitis and Orbital Apex Syndrome: Importance of Early Diagnosis and Management. 61
29796053 2018
6
Anti-PD-L1 Treatment Induced Central Diabetes Insipidus. 61
29220526 2018
7
[Clinical features and prognosis of 18 cases of primary lymphocytic hypophysitis]. 61
29343033 2018
8
Occam's Razor Could Not Cut It: Tale of 2 Headaches in a Postpartum Patient: A Case Report. 61
28691978 2017
9
[A Case of Lymphocytic Adenohypophysitis Presenting Visual Disturbance in the Third Trimester of Pregnancy]. 61
28202834 2017
10
An Overview of Diagnosis of Primary Autoimmune Hypophysitis in a Prospective Single-Center Experience. 61
27165294 2017
11
Post-partum hypoglycemia and hypothermia as first manifestations of lymphocytic adenohypophysitis: A case report. 61
26786534 2016
12
Clinical characteristics, management, and outcome of 22 cases of primary hypophysitis. 61
25325267 2014
13
Variant of lymphocytic infundibulo-neurohypophysitis presenting with unique clinical and radiological features. 61
23238905 2012
14
Pituitary autoimmune disease: nuances in clinical presentation. 61
22426958 2012
15
Novel strategy to treat a case of recurrent lymphocytic hypophysitis using rituximab. 61
22443503 2012
16
[MRI of hypophysitis]. 61
22516764 2012
17
Sudden death in a dog with lymphoplasmacytic hypophysitis. 61
21392780 2011
18
Lymphocytic adenohypophysitis. 61
21592417 2011
19
Lymphocytic panhypophysitis: its clinical features in Japanese cases. 61
23885185 2011
20
[Autoimmune polyendocrine syndrome type 2 associated with autoimmune hypophysitis and coeliac disease]. 61
21250496 2010
21
Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy. 61
20807820 2010
22
Adenohypophysitis in rat pituitary allografts. 61
20586813 2010
23
[Two cases of isolated ACTH deficiency suspected as depression with severe appetite loss]. 61
21226246 2010
24
Hypophysitis caused by Rathke's cleft cyst. Case report. 61
17384498 2007
25
Granulomatous adenohypophysitis after interferon and ribavirin therapy. 61
17490932 2007
26
Imaging of neurologic disorders associated with pregnancy and the postpartum period. 61
17235001 2007
27
Longitudinal study of patients with idiopathic isolated TSH deficiency: possible progression of pituitary dysfunction in lymphocytic adenohypophysitis. 61
16896268 2006
28
Concurrent lymphocytic hypophysitis and pituitary adenoma. Case report and review of the literature. 61
17219839 2006
29
[Autoimmune infundibulo -hypophysitis (lymphocytic adenohypophysitis and lymphocytic infundibulo-neurohypophysitis)]. 61
16776088 2006
30
Lymphocytic hypophysitis: disease spectrum and approach to diagnosis and therapy. 61
16703407 2006
31
Pituitary apoplexy as a consequence of lymphocytic adenohypophysitis in a pregnant woman: a case report. 61
15949237 2005
32
Imaging the sella and parasellar region. 61
15927868 2005
33
Pituitary abscess in a patient with painless thyroiditis. 61
15749430 2005
34
Factors affecting the susceptibility of the mouse pituitary gland to CD8 T-cell-mediated autoimmunity. 61
15009425 2004
35
Therapy for lymphocytic adenohypophysitis. 61
12636229 2003
36
Detection of autoantibodies against the pituitary-specific proteins in patients with lymphocytic hypophysitis. 61
12457452 2002
37
Lymphocytic adenohypophysitis simulating a pituitary adenoma in a pregnant woman. 61
12528294 2002
38
Spectrum of different types of hypophysitis: a clinicopathologic study of hypophysitis in 31 cases. 61
12446917 2002
39
[Follow-up studies of optic neuritis with lymphocytic adenohypophysitis]. 61
11558164 2001
40
Severe lymphocytic adenohypophysitis with selective disappearance of prolactin cells: a histologic, ultrastructural and immunoelectron microscopic study. 61
11515793 2001
41
Lymphocytic hypophysitis: its expanding features. 61
11383913 2001
42
Dynamic MR imaging of neurohypophyseal germ cell tumors for differential diagnosis of infundibular diseases. 61
11092476 2000
43
Lymphocytic adenohypophysitis mimicking a pituitary macroadenoma. 61
10926106 2000
44
Spontaneous recovery from pathologically confirmed lymphocytic adenohypophysitis with a dramatic reduction of hypophyseal size. 61
10563747 1999
45
Probable lymphocytic hypophysitis diagnosed by short-term serial computed tomography and gallium-67 scintigraphy--case report. 61
10193154 1999
46
Symptomatic Rathke's cleft cyst coexisting with central diabetes insipidus and hypophysitis: case report. 61
10426586 1999
47
'Stalkitis' in a pregnant 32-year-old woman: a rare cause of diabetes insipidus. 61
10901882 1999
48
Lymphocytic hypophysitis presenting with diabetes insipidus: MR findings. 61
10460381 1999
49
[Report of four cases of lymphocytic infundibuloneurohypophysitis]. 61
9757460 1998
50
Lymphocytic adenohypophysitis: skull radiographs and MRI. 61
9541922 1998

Variations for Adenohypophysitis

Expression for Adenohypophysitis

Search GEO for disease gene expression data for Adenohypophysitis.

Pathways for Adenohypophysitis

GO Terms for Adenohypophysitis

Cellular components related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 PRL GH1

Biological processes related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.5 PRL IL2RA CD4
2 cytokine-mediated signaling pathway GO:0019221 9.43 POMC IL2RA CD4
3 response to nutrient levels GO:0031667 9.4 PRL GH1
4 positive regulation of T cell proliferation GO:0042102 9.37 IL2RA CD4
5 signal transduction GO:0007165 9.35 TRH PRL POMC GH1 CD4
6 positive regulation of JAK-STAT cascade GO:0046427 9.16 PRL GH1
7 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.62 PRL GH1

Molecular functions related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prolactin receptor binding GO:0005148 8.96 PRL GH1
2 hormone activity GO:0005179 8.92 TRH PRL POMC GH1

Sources for Adenohypophysitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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