MCID: ADN064
MIFTS: 39

Adenohypophysitis

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Adenohypophysitis

Summaries for Adenohypophysitis

MalaCards based summary : Adenohypophysitis, also known as anterior pituitary hypophysitis, is related to pituitary apoplexy and lymphocytic hypophysitis. An important gene associated with Adenohypophysitis is PRL (Prolactin), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. Affiliated tissues include pituitary, thyroid and placenta, and related phenotypes are diplopia and sensorineural hearing impairment

Related Diseases for Adenohypophysitis

Diseases related to Adenohypophysitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 pituitary apoplexy 29.9 POMC PRL
2 lymphocytic hypophysitis 29.7 GH1 POMC
3 adenoma 29.6 GH1 POMC PRL
4 diabetes insipidus 29.3 POMC PRL
5 pituitary tumors 29.3 GH1 POMC PRL
6 hypopituitarism 29.3 GH1 POMC PRL
7 hypothyroidism, congenital, nongoitrous, 4 29.1 GH1 POMC PRL
8 pituitary gland disease 29.1 GH1 POMC PRL
9 hypothyroidism 28.3 GH1 POMC PRL TRH
10 generalized resistance to thyroid hormone 10.4 PRL TRH
11 fibrous dysplasia/mccune-albright syndrome 10.3 GH1 PRL
12 tsh producing pituitary tumor 10.3 GH1 PRL
13 pituitary adenoma 1, multiple types 10.3 GH1 PRL
14 gigantism 10.3 GH1 PRL
15 pituitary infarct 10.2 POMC PRL
16 tetrahydrobiopterin deficiency 10.2 GH1 PRL
17 chiasmal syndrome 10.2 POMC PRL
18 pituitary carcinoma 10.2 POMC PRL
19 sella turcica neoplasm 10.2 POMC PRL
20 tuberculum sellae meningioma 10.2 POMC PRL
21 pituitary stalk interruption syndrome 10.2 GH1 PRL
22 nelson syndrome 10.2 POMC PRL
23 sheehan syndrome 10.1 POMC PRL
24 acth-secreting pituitary adenoma 10.1 POMC PRL
25 central nervous system organ benign neoplasm 10.1 POMC PRL
26 suprasellar meningioma 10.1 POMC TRH
27 diabetes insipidus, neurohypophyseal 10.1 POMC PRL
28 mccune-albright syndrome 10.1 GH1 PRL
29 pituitary adenoma 10.1
30 sex differentiation disease 10.1 POMC PRL
31 adrenal cortex disease 10.1 POMC PRL
32 fibrous dysplasia 10.1 GH1 PRL
33 adrenal gland disease 10.1 POMC PRL
34 premenstrual tension 10.0 POMC PRL
35 hypoadrenalism 10.0 GH1 POMC
36 endogenous depression 10.0 POMC TRH
37 gynecomastia 9.9 POMC PRL
38 thyroiditis 9.9
39 pilonidal sinus 9.9 CD4 IL2RA
40 female reproductive system disease 9.8 POMC PRL
41 pseudohypoparathyroidism, type ia 9.8 GH1 PRL TRH
42 craniopharyngioma 9.8 GH1 PRL TRH
43 hyperthyroidism 9.8 GH1 PRL TRH
44 chronic graft versus host disease 9.8 CD4 IL2RA
45 gonadal disease 9.8 GH1 POMC
46 hypoglycemia 9.7
47 galactorrhea 9.7
48 central congenital hypothyroidism 9.7
49 aging 9.7
50 precocious puberty 9.7

Graphical network of the top 20 diseases related to Adenohypophysitis:



Diseases related to Adenohypophysitis

Symptoms & Phenotypes for Adenohypophysitis

Human phenotypes related to Adenohypophysitis:

59 32 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 diplopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000651
2 sensorineural hearing impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0000407
3 pallor 59 32 frequent (33%) Frequent (79-30%) HP:0000980
4 hashimoto thyroiditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000872
5 hyponatremia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002902
6 blurred vision 59 32 frequent (33%) Frequent (79-30%) HP:0000622
7 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
8 panhypopituitarism 59 32 hallmark (90%) Very frequent (99-80%) HP:0000871
9 secondary growth hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008240
10 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
11 decreased circulating cortisol level 59 32 frequent (33%) Frequent (79-30%) HP:0008163
12 decreased serum estradiol 59 32 frequent (33%) Frequent (79-30%) HP:0008214
13 orthostatic hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0001278
14 decreased testosterone in males 59 32 frequent (33%) Frequent (79-30%) HP:0008230
15 pituitary hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0008245
16 adrenocorticotropin deficient adrenal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011735
17 adrenocorticotropic hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011748
18 prolactin excess 59 32 frequent (33%) Frequent (79-30%) HP:0000870
19 antinuclear antibody positivity 59 32 occasional (7.5%) Occasional (29-5%) HP:0003493
20 nausea 59 32 frequent (33%) Frequent (79-30%) HP:0002018
21 amenorrhea 59 32 frequent (33%) Frequent (79-30%) HP:0000141
22 prolactin deficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0008202
23 poor appetite 59 32 occasional (7.5%) Occasional (29-5%) HP:0004396
24 decreased female libido 59 32 frequent (33%) Frequent (79-30%) HP:0030018
25 progressive visual field defects 59 32 frequent (33%) Frequent (79-30%) HP:0007987
26 hyposthenuria 59 32 frequent (33%) Frequent (79-30%) HP:0003158
27 gonadotropin deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008213
28 abnormal size of pituitary gland 59 32 frequent (33%) Frequent (79-30%) HP:0012504
29 decreased male libido 59 32 frequent (33%) Frequent (79-30%) HP:0040306
30 chronic lymphocytic meningitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0007041
31 normochromic anemia 59 32 frequent (33%) Frequent (79-30%) HP:0001895
32 abnormal thalamic mri signal intensity 59 32 frequent (33%) Frequent (79-30%) HP:0012696

MGI Mouse Phenotypes related to Adenohypophysitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.02 CD4 IL2RA POMC PRL TRH

Drugs & Therapeutics for Adenohypophysitis

Search Clinical Trials , NIH Clinical Center for Adenohypophysitis

Genetic Tests for Adenohypophysitis

Anatomical Context for Adenohypophysitis

MalaCards organs/tissues related to Adenohypophysitis:

41
Pituitary, Thyroid, Placenta

Publications for Adenohypophysitis

Articles related to Adenohypophysitis:

(show top 50) (show all 67)
# Title Authors Year
1
Ipilimumab-induced Adenohypophysitis and Orbital Apex Syndrome: Importance of Early Diagnosis and Management. ( 29796053 )
2018
2
Post-partum hypoglycemia and hypothermia as first manifestations of lymphocytic adenohypophysitis: A case report. ( 26786534 )
2016
3
Congenital adenohypophyseal hypoplasia associated with secondary hypothyroidism in a 2-week-old Portuguese water dog. ( 23204587 )
2012
4
Lymphocytic adenohypophysitis. ( 21592417 )
2011
5
Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy. ( 20807820 )
2010
6
Adenohypophysitis in rat pituitary allografts. ( 20586813 )
2010
7
Adrenomedullin expression in pituitary adenomas and nontumoral adenohypophyses. ( 17952853 )
2008
8
[Relationship of plasma ghrelin and adenohypophyseal hormone levels in female precocious puberty]. ( 18925720 )
2008
9
Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: cytoplasmic clusterin localization in adenohypophysis is related to aging. ( 18239862 )
2008
10
Granulomatous adenohypophysitis after interferon and ribavirin therapy. ( 17490932 )
2007
11
Longitudinal study of patients with idiopathic isolated TSH deficiency: possible progression of pituitary dysfunction in lymphocytic adenohypophysitis. ( 16896268 )
2006
12
Pituitary apoplexy as a consequence of lymphocytic adenohypophysitis in a pregnant woman: a case report. ( 15949237 )
2005
13
Expression of adenohypophyseal-hormone receptors in a murine folliculo-stellate cell line. ( 15326563 )
2004
14
Therapy for lymphocytic adenohypophysitis. ( 12636229 )
2003
15
Thyrotropin-releasing hormone-induced down-regulation of pyroglutamyl aminopeptidase II activity involves L-type calcium channels and cam kinase activities in cultures of adenohypophyseal cells. ( 11999717 )
2002
16
Lymphocytic adenohypophysitis simulating a pituitary adenoma in a pregnant woman. ( 12528294 )
2002
17
Severe lymphocytic adenohypophysitis with selective disappearance of prolactin cells: a histologic, ultrastructural and immunoelectron microscopic study. ( 11515793 )
2001
18
Lymphocytic adenohypophysitis mimicking a pituitary macroadenoma. ( 10926106 )
2000
19
The regulation of adenohypophyseal prolactin secretion: effect of triiodothyronine and methylene blue on estrogenized rat adenohypophysis. ( 10984069 )
2000
20
Spontaneous recovery from pathologically confirmed lymphocytic adenohypophysitis with a dramatic reduction of hypophyseal size. ( 10563747 )
1999
21
Comparative immunohistochemical study of stellate cells in normal canine and equine adenohypophyses and in pituitary tumours. ( 9500236 )
1998
22
Lymphocytic adenohypophysitis: skull radiographs and MRI. ( 9541922 )
1998
23
Multiple hypothalamic factors regulate pyroglutamyl peptidase II in cultures of adenohypophyseal cells: role of the cAMP pathway. ( 9576608 )
1998
24
Lymphocytic adenohypophysitis and neurohypophysitis. ( 9187559 )
1997
25
Lymphocytic adenohypophysitis and lymphocytic infundibuloneurohypophysitis. ( 9152609 )
1997
26
Long-term clinical course of two cases of lymphocytic adenohypophysitis. ( 8930533 )
1996
27
Effects of intravenously infused pituitary adenylate cyclase-activating polypeptide on adenohypophyseal Hormone secretion in normal men. ( 8875442 )
1996
28
Lymphocytic adenohypophysitis: contrast-enhanced MR imaging in five cases. ( 7892490 )
1995
29
Lymphocytic adenohypophysitis: magnetic resonance imaging features of two new cases and a review of the literature. ( 7758238 )
1995
30
Differentiating lymphocytic adenohypophysitis from pituitary adenoma in the peripartum patient. ( 7623353 )
1995
31
Lymphocytic Adenohypophysitis Associated with Rathke's Cleft Cyst. ( 12114815 )
1995
32
Immunohistochemical demonstration of adenohypophyseal hormones during postnatal ontogenesis in the Gray Short-tailed Opossum, Monodelphis domestica (marsupialia). ( 8835137 )
1995
33
Thyrotropin-releasing hormone downregulates pyroglutamyl peptidase II activity in adenohypophyseal cells. ( 7969791 )
1994
34
[Membrane receptors and coupling proteins in adenohypophyseal cells]. ( 8242419 )
1993
35
Adenohypophyseal and sex hormones in pediatric rheumatic diseases. ( 8496873 )
1993
36
Lymphocytic adenohypophysitis with sudden onset of diabetes insipidus in menopausal female--case report. ( 1381061 )
1992
37
Preoperative diagnosis of lymphocytic hypophysitis (adenohypophysitis) unresponsive to short course dexamethasone: case report. ( 1545900 )
1992
38
Lymphocytic adenohypophysitis presenting as infertility. Case report. ( 2013781 )
1991
39
Lymphocytic adenohypophysitis: an immunohistochemical study. ( 1891758 )
1991
40
[A case of pregnancy-induced lymphocytic adenohypophysitis complicated by postpartum painless thyroiditis]. ( 2070891 )
1991
41
Lymphocytic adenohypophysitis: a pituitary mass lesion occurring in pregnancy. Proposal for medical treatment. ( 2048602 )
1991
42
Adenohypophysitis associated with sebaceous gland atrophy in a dog. ( 1949513 )
1991
43
Lymphocytic adenohypophysitis accompanying occlusion of bilateral internal carotid arteries--case report. ( 1699152 )
1990
44
Relationship between adenohypophyseal and steroid hormones and variations in serum and urinary melatonin levels during the ovarian cycle, perimenopause and menopause in healthy women. ( 2308340 )
1990
45
The effect of oxytocin infusion on adenohypophyseal function in man. ( 2160873 )
1990
46
Twenty-four-hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts. ( 2172282 )
1990
47
Lymphocytic adenohypophysitis: report of two cases. ( 2700055 )
1989
48
Lymphocytic adenohypophysitis in a man. ( 3208233 )
1988
49
Lymphocytic adenohypophysitis. ( 3278777 )
1988
50
Lymphocytic adenohypophysitis: clinical, radiological, and magnetic resonance imaging characterization. ( 3380286 )
1988

Variations for Adenohypophysitis

Expression for Adenohypophysitis

Search GEO for disease gene expression data for Adenohypophysitis.

Pathways for Adenohypophysitis

GO Terms for Adenohypophysitis

Cellular components related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.96 POMC TRH
2 endosome lumen GO:0031904 8.62 GH1 PRL

Biological processes related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.5 CD4 IL2RA POMC
2 response to estradiol GO:0032355 9.46 CD4 GH1
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.43 CD4 GH1
4 cell surface receptor signaling pathway GO:0007166 9.43 CD4 IL2RA PRL
5 positive regulation of T cell proliferation GO:0042102 9.4 CD4 IL2RA
6 response to nutrient levels GO:0031667 9.37 GH1 PRL
7 positive regulation of JAK-STAT cascade GO:0046427 9.16 GH1 PRL
8 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 GH1 PRL
9 regulation of signaling receptor activity GO:0010469 8.92 GH1 POMC PRL TRH

Molecular functions related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prolactin receptor binding GO:0005148 8.96 GH1 PRL
2 hormone activity GO:0005179 8.92 GH1 POMC PRL TRH

Sources for Adenohypophysitis

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11 DGIdb
17 ExPASy
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62 PubMed
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69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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