MCID: ADN064
MIFTS: 40

Adenohypophysitis

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Adenohypophysitis

Summaries for Adenohypophysitis

MalaCards based summary : Adenohypophysitis, also known as anterior pituitary hypophysitis, is related to adenoma and pituitary apoplexy. An important gene associated with Adenohypophysitis is PRL (Prolactin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and JAK-STAT signaling pathway (KEGG). Affiliated tissues include pituitary, thyroid and cortex, and related phenotypes are diplopia and sensorineural hearing impairment

Related Diseases for Adenohypophysitis

Diseases related to Adenohypophysitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.2 GH1 POMC PRL
2 pituitary apoplexy 29.9 POMC PRL
3 diabetes insipidus 29.9 POMC PRL
4 hypopituitarism 29.9 GH1 POMC PRL
5 lymphocytic hypophysitis 29.9 GH1 POMC
6 amenorrhea 29.7 POMC PRL TRH
7 hypothyroidism 29.4 GH1 POMC PRL TRH
8 hypothyroidism, congenital, nongoitrous, 4 29.4 GH1 POMC PRL TRH
9 pituitary gland disease 29.4 GH1 POMC PRL TRH
10 pituitary adenoma 10.2
11 generalized resistance to thyroid hormone 10.1 PRL TRH
12 fibrous dysplasia 10.1 GH1 PRL
13 fibrous dysplasia/mccune-albright syndrome 10.1 GH1 PRL
14 mccune-albright syndrome 10.1 GH1 PRL
15 gigantism 10.1 GH1 PRL
16 head injury 10.1 IL2RA PRL
17 pituitary infarct 10.1 POMC PRL
18 tetrahydrobiopterin deficiency 10.1 GH1 PRL
19 chiasmal syndrome 10.1 POMC PRL
20 pituitary adenoma 1, multiple types 10.1 GH1 PRL
21 pituitary carcinoma 10.1 POMC PRL
22 hypothyroidism, central, and testicular enlargement 10.1 PRL TRH
23 sella turcica neoplasm 10.1 POMC PRL
24 tuberculum sellae meningioma 10.0 POMC PRL
25 pituitary stalk interruption syndrome 10.0 GH1 PRL
26 nelson syndrome 10.0 POMC PRL
27 sheehan syndrome 10.0 POMC PRL
28 acth-secreting pituitary adenoma 10.0 POMC PRL
29 abducens nerve disease 10.0 POMC PRL
30 suprasellar meningioma 10.0 POMC TRH
31 diabetes insipidus, neurohypophyseal 10.0 POMC PRL
32 sex differentiation disease 10.0 POMC PRL
33 premenstrual tension 10.0 POMC PRL
34 adrenal cortex disease 10.0 POMC PRL
35 hypoadrenalism 10.0 GH1 POMC
36 adrenal rest tumor 10.0 POMC PRL
37 endocrine organ benign neoplasm 10.0 POMC PRL
38 gynecomastia 10.0 POMC PRL
39 vernal conjunctivitis 10.0 IL2RA POMC
40 pilonidal sinus 10.0 CD4 IL2RA
41 hyperandrogenism 9.9 POMC PRL
42 pseudohypoparathyroidism, type ia 9.9 GH1 PRL TRH
43 craniopharyngioma 9.9 GH1 PRL TRH
44 hyperthyroidism 9.9 GH1 PRL TRH
45 galactorrhea 9.9
46 aging 9.9
47 dermoid cyst 9.9
48 infertility 9.9
49 thyroiditis 9.9
50 hypoglycemia 9.9

Graphical network of the top 20 diseases related to Adenohypophysitis:



Diseases related to Adenohypophysitis

Symptoms & Phenotypes for Adenohypophysitis

Human phenotypes related to Adenohypophysitis:

59 32 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 diplopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000651
2 sensorineural hearing impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0000407
3 pallor 59 32 frequent (33%) Frequent (79-30%) HP:0000980
4 hashimoto thyroiditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000872
5 hyponatremia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002902
6 blurred vision 59 32 frequent (33%) Frequent (79-30%) HP:0000622
7 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
8 panhypopituitarism 59 32 hallmark (90%) Very frequent (99-80%) HP:0000871
9 secondary growth hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008240
10 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
11 decreased circulating cortisol level 59 32 frequent (33%) Frequent (79-30%) HP:0008163
12 decreased serum estradiol 59 32 frequent (33%) Frequent (79-30%) HP:0008214
13 orthostatic hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0001278
14 decreased testosterone in males 59 32 frequent (33%) Frequent (79-30%) HP:0008230
15 pituitary hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0008245
16 adrenocorticotropin deficient adrenal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011735
17 adrenocorticotropic hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011748
18 prolactin excess 59 32 frequent (33%) Frequent (79-30%) HP:0000870
19 antinuclear antibody positivity 59 32 occasional (7.5%) Occasional (29-5%) HP:0003493
20 nausea 59 32 frequent (33%) Frequent (79-30%) HP:0002018
21 amenorrhea 59 32 frequent (33%) Frequent (79-30%) HP:0000141
22 prolactin deficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0008202
23 poor appetite 59 32 occasional (7.5%) Occasional (29-5%) HP:0004396
24 decreased female libido 59 32 frequent (33%) Frequent (79-30%) HP:0030018
25 progressive visual field defects 59 32 frequent (33%) Frequent (79-30%) HP:0007987
26 hyposthenuria 59 32 frequent (33%) Frequent (79-30%) HP:0003158
27 gonadotropin deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008213
28 abnormal size of pituitary gland 59 32 frequent (33%) Frequent (79-30%) HP:0012504
29 decreased male libido 59 32 frequent (33%) Frequent (79-30%) HP:0040306
30 chronic lymphocytic meningitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0007041
31 normochromic anemia 59 32 frequent (33%) Frequent (79-30%) HP:0001895
32 abnormal thalamic mri signal intensity 59 32 frequent (33%) Frequent (79-30%) HP:0012696

MGI Mouse Phenotypes related to Adenohypophysitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.02 CD4 IL2RA POMC PRL TRH

Drugs & Therapeutics for Adenohypophysitis

Search Clinical Trials , NIH Clinical Center for Adenohypophysitis

Genetic Tests for Adenohypophysitis

Anatomical Context for Adenohypophysitis

MalaCards organs/tissues related to Adenohypophysitis:

41
Pituitary, Thyroid, Cortex, Placenta, Adrenal Cortex

Publications for Adenohypophysitis

Articles related to Adenohypophysitis:

(show all 47)
# Title Authors Year
1
Ipilimumab-induced Adenohypophysitis and Orbital Apex Syndrome: Importance of Early Diagnosis and Management. ( 29796053 )
2018
2
Post-partum hypoglycemia and hypothermia as first manifestations of lymphocytic adenohypophysitis: A case report. ( 26786534 )
2016
3
Lymphocytic adenohypophysitis. ( 21592417 )
2011
4
Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy. ( 20807820 )
2010
5
Adenohypophysitis in rat pituitary allografts. ( 20586813 )
2010
6
Granulomatous adenohypophysitis after interferon and ribavirin therapy. ( 17490932 )
2007
7
Longitudinal study of patients with idiopathic isolated TSH deficiency: possible progression of pituitary dysfunction in lymphocytic adenohypophysitis. ( 16896268 )
2006
8
Pituitary apoplexy as a consequence of lymphocytic adenohypophysitis in a pregnant woman: a case report. ( 15949237 )
2005
9
Therapy for lymphocytic adenohypophysitis. ( 12636229 )
2003
10
Lymphocytic adenohypophysitis simulating a pituitary adenoma in a pregnant woman. ( 12528294 )
2002
11
Severe lymphocytic adenohypophysitis with selective disappearance of prolactin cells: a histologic, ultrastructural and immunoelectron microscopic study. ( 11515793 )
2001
12
Lymphocytic adenohypophysitis mimicking a pituitary macroadenoma. ( 10926106 )
2000
13
Spontaneous recovery from pathologically confirmed lymphocytic adenohypophysitis with a dramatic reduction of hypophyseal size. ( 10563747 )
1999
14
Lymphocytic adenohypophysitis: skull radiographs and MRI. ( 9541922 )
1998
15
Lymphocytic adenohypophysitis and neurohypophysitis. ( 9187559 )
1997
16
Lymphocytic adenohypophysitis and lymphocytic infundibuloneurohypophysitis. ( 9152609 )
1997
17
Long-term clinical course of two cases of lymphocytic adenohypophysitis. ( 8930533 )
1996
18
Lymphocytic adenohypophysitis: contrast-enhanced MR imaging in five cases. ( 7892490 )
1995
19
Lymphocytic adenohypophysitis: magnetic resonance imaging features of two new cases and a review of the literature. ( 7758238 )
1995
20
Differentiating lymphocytic adenohypophysitis from pituitary adenoma in the peripartum patient. ( 7623353 )
1995
21
Lymphocytic Adenohypophysitis Associated with Rathke's Cleft Cyst. ( 12114815 )
1995
22
Lymphocytic adenohypophysitis with sudden onset of diabetes insipidus in menopausal female--case report. ( 1381061 )
1992
23
Preoperative diagnosis of lymphocytic hypophysitis (adenohypophysitis) unresponsive to short course dexamethasone: case report. ( 1545900 )
1992
24
Lymphocytic adenohypophysitis presenting as infertility. Case report. ( 2013781 )
1991
25
Lymphocytic adenohypophysitis: an immunohistochemical study. ( 1891758 )
1991
26
[A case of pregnancy-induced lymphocytic adenohypophysitis complicated by postpartum painless thyroiditis]. ( 2070891 )
1991
27
Lymphocytic adenohypophysitis: a pituitary mass lesion occurring in pregnancy. Proposal for medical treatment. ( 2048602 )
1991
28
Adenohypophysitis associated with sebaceous gland atrophy in a dog. ( 1949513 )
1991
29
Lymphocytic adenohypophysitis accompanying occlusion of bilateral internal carotid arteries--case report. ( 1699152 )
1990
30
Lymphocytic adenohypophysitis: report of two cases. ( 2700055 )
1989
31
Lymphocytic adenohypophysitis in a man. ( 3208233 )
1988
32
Lymphocytic adenohypophysitis. ( 3278777 )
1988
33
Lymphocytic adenohypophysitis: clinical, radiological, and magnetic resonance imaging characterization. ( 3380286 )
1988
34
A case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement: a possible variant of lymphocytic adenohypophysitis. ( 3215147 )
1988
35
Lymphocytic adenohypophysitis. Report of a case with demonstration of spontaneous tumour regression and a review of the literature. ( 3077051 )
1988
36
Lymphocytic adenohypophysitis of pregnancy with complete recovery. ( 3601028 )
1987
37
Lymphocytic adenohypophysitis causing pituitary mass. ( 3540725 )
1987
38
Lymphoid adenohypophysitis. ( 3739708 )
1986
39
Lymphocytic adenohypophysitis. A review and a case. ( 4017662 )
1985
40
Lymphocytic adenohypophysitis of pregnancy simulating a pituitary adenoma: a distinct pathological entity. Report of two cases. ( 7054413 )
1982
41
Lymphoid adenohypophysitis with radiologic and clinical findings resembling a pituitary tumor. ( 6810678 )
1982
42
Galactorrhea associated with lymphocytic adenohypophysitis. Case report. ( 7195731 )
1981
43
Lymphocytic adenohypophysitis: autoimmune disorder of the pituitary gland. ( 6779608 )
1980
44
Lymphoid adenohypophysitis presenting as a pituitary tumor. ( 7424950 )
1980
45
Chronic adenohypophysitis in a rhesus monkey immunised with extracts of human placenta. ( 4101493 )
1970
46
Allergic adrenalitis and adenohypophysitis: further observations on production and passive transfer. ( 5773150 )
1969
47
Allergic adenohypophysitis: new experimental disease of the pituitary gland. ( 6057291 )
1967

Variations for Adenohypophysitis

Expression for Adenohypophysitis

Search GEO for disease gene expression data for Adenohypophysitis.

Pathways for Adenohypophysitis

GO Terms for Adenohypophysitis

Cellular components related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.96 GH1 PRL
2 secretory granule GO:0030141 8.8 POMC PRL TRH

Biological processes related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.54 CD4 IL2RA POMC
2 cell surface receptor signaling pathway GO:0007166 9.5 CD4 IL2RA PRL
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.46 CD4 GH1
4 positive regulation of T cell proliferation GO:0042102 9.43 CD4 IL2RA
5 response to nutrient levels GO:0031667 9.4 GH1 PRL
6 positive regulation of JAK-STAT cascade GO:0046427 9.26 GH1 PRL
7 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.16 GH1 PRL
8 response to estradiol GO:0032355 9.13 CD4 GH1 PRL
9 regulation of signaling receptor activity GO:0010469 8.92 GH1 POMC PRL TRH

Molecular functions related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prolactin receptor binding GO:0005148 8.96 GH1 PRL
2 hormone activity GO:0005179 8.92 GH1 POMC PRL TRH

Sources for Adenohypophysitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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