MCID: ADN015
MIFTS: 32

Adenoid Basal Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Adenoid Basal Cell Carcinoma

MalaCards integrated aliases for Adenoid Basal Cell Carcinoma:

Name: Adenoid Basal Cell Carcinoma 12 15
Skin Adenoid Basal Cell Carcinoma 12
Basal Cell Carcinoma - Adenoid 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4294
UMLS 73 C1304296

Summaries for Adenoid Basal Cell Carcinoma

MalaCards based summary : Adenoid Basal Cell Carcinoma, also known as skin adenoid basal cell carcinoma, is related to adenoid cystic carcinoma and cutaneous adenocystic carcinoma. An important gene associated with Adenoid Basal Cell Carcinoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Gastric cancer and Cell cycle Role of SCF complex in cell cycle regulation. Affiliated tissues include skin, lung and bone, and related phenotypes are endocrine/exocrine gland and integument

Related Diseases for Adenoid Basal Cell Carcinoma

Diseases related to Adenoid Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 30.3 KIT KRT7 PGR
2 cutaneous adenocystic carcinoma 29.5 B2M CEACAM5 KRT7 LALBA
3 basal cell carcinoma 1 10.5
4 basal cell carcinoma 10.5
5 renal oncocytoma 10.3 KIT KRT7
6 large cell neuroendocrine carcinoma 10.3 KIT KRT7
7 ovarian brenner tumor 10.2 KIT KRT7
8 prostatic acinar adenocarcinoma 10.2 KIT KRT7
9 dysgerminoma 10.2 KIT KRT7
10 colonic pseudo-obstruction 10.2 B2M KIT
11 ceruminoma 10.2 KIT KRT7
12 jejunal cancer 10.2 KIT KRT7
13 muscle cancer 10.2 KIT PGR
14 cecum adenocarcinoma 10.2 B2M KRT7
15 dysgerminoma of ovary 10.2 KIT PGR
16 ovarian cystic teratoma 10.2 B2M KRT7
17 intratubular embryonal carcinoma 10.2 KIT KRT7
18 sweat gland disease 10.2 KRT7 PGR
19 sex cord-gonadal stromal tumor 10.2 KRT7 PGR
20 spindle cell carcinoma 10.2 KRT7 PGR
21 fibrosarcoma of bone 10.2 CDKN2A KIT
22 central nervous system melanocytic neoplasm 10.2 CDKN2A KIT
23 extragonadal seminoma 10.2 CEACAM5 KIT
24 neurofibroma 10.2 CDKN2A KIT
25 ewing's family of tumors 10.2 CDKN2A KIT
26 cystadenoma 10.2 KRT7 PGR
27 benign breast phyllodes tumor 10.2 KIT PGR
28 pharynx cancer 10.2 CDKN2A KIT
29 ovarian cancer 1 10.2 CEACAM5 KRT7
30 biliary tract neoplasm 10.2 CDKN2A KRT7
31 gastrointestinal system benign neoplasm 10.2 CEACAM5 KRT7
32 vulva cancer 10.2 CDKN2A KRT7
33 anus cancer 10.2 CDKN2A KRT7
34 eccrine papillary adenocarcinoma 10.2 KRT7 PGR
35 inverted papilloma 10.2 CDKN2A KRT7
36 pancreatic ductal carcinoma 10.2 CDKN2A KRT7
37 ovary adenocarcinoma 10.2 CEACAM5 KRT7
38 liver leiomyoma 10.2 CEACAM5 KIT
39 adenocarcinoma in situ 10.2 CDKN2A KRT7
40 bile duct adenocarcinoma 10.2 CEACAM5 KRT7
41 basaloid squamous cell carcinoma 10.2 CDKN2A KRT7
42 cervical adenosquamous carcinoma 10.2 CDKN2A KRT7
43 fox-fordyce disease 10.2 CEACAM5 KIT
44 mucinous adenocarcinoma 10.2 CDKN2A KRT7
45 endosalpingiosis 10.2 KRT7 PGR
46 acute kidney tubular necrosis 10.2 B2M CDKN2A
47 skin squamous cell carcinoma 10.2 B2M CDKN2A
48 cystic nephroma 10.2 KIT PGR
49 benign metastasizing leiomyoma 10.2 KRT7 PGR
50 uterine sarcoma 10.2 ESR1 KIT

Graphical network of the top 20 diseases related to Adenoid Basal Cell Carcinoma:



Diseases related to Adenoid Basal Cell Carcinoma

Symptoms & Phenotypes for Adenoid Basal Cell Carcinoma

MGI Mouse Phenotypes related to Adenoid Basal Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 B2M CDKN2A ESR1 KIT LALBA PGR
2 integument MP:0010771 9.43 B2M CDKN2A ESR1 KIT LALBA PGR
3 neoplasm MP:0002006 9.1 B2M CDKN2A ESR1 KIT PGR SPN

Drugs & Therapeutics for Adenoid Basal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Adenoid Basal Cell Carcinoma

Genetic Tests for Adenoid Basal Cell Carcinoma

Anatomical Context for Adenoid Basal Cell Carcinoma

MalaCards organs/tissues related to Adenoid Basal Cell Carcinoma:

41
Skin, Lung, Bone, Colon, Breast, Ovary, Prostate

Publications for Adenoid Basal Cell Carcinoma

Articles related to Adenoid Basal Cell Carcinoma:

# Title Authors Year
1
Adenoid basal cell carcinoma: a rare facet of basal cell carcinoma. ( 27095806 )
2016
2
CD117 and CD43 are useful adjuncts in the distinction of adenoid cystic carcinoma from adenoid basal cell carcinoma. ( 25551301 )
2015
3
Coexistence of Solid (Nodular) and Differentiated (Adenoid) Basal Cell Carcinoma at the Same Anatomical Site. ( 26538745 )
2015
4
Adenoid basal cell carcinoma and its mimics. ( 23723508 )
2013
5
Adenoid Basal cell carcinoma simulating ameloblastoma. ( 19549180 )
2009
6
A Case of Axillary Adenoid Basal Cell Carcinoma. ( 27303153 )
2008
7
Tenascin expression in adenoid basal cell carcinoma of the skin. ( 8615597 )
1996
8
Giant adenoid basal cell carcinoma. ( 8060083 )
1994
9
Primary adenoid cystic carcinoma of the skin. A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma. ( 3010759 )
1986
10
Adenoid basal cell carcinoma of the vulva. ( 7185765 )
1982

Variations for Adenoid Basal Cell Carcinoma

Cosmic variations for Adenoid Basal Cell Carcinoma:

9 (show top 50) (show all 687)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6926860 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 9
2 COSM6926861 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 9
3 COSM6969201 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 9
4 COSM6953811 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 9
5 COSM6926862 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 9
6 COSM6936924 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 9
7 COSM3691166 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 9
8 COSM212945 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 9
9 COSM6953809 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 9
10 COSM6936922 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 9
11 COSM6926855 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 9
12 COSM6912933 TRAF7 skin,NS,carcinoma,basal cell carcinoma c.1802C>T p.T601I 16:2176104-2176104 9
13 COSM6949578 TP63 skin,NS,carcinoma,basal cell carcinoma c.1922C>T p.A641V 3:189894381-189894381 9
14 COSM44071 TP53 skin,NS,carcinoma,basal cell carcinoma c.955A>G p.K319E 17:7673573-7673573 9
15 COSM44097 TP53 skin,NS,carcinoma,basal cell carcinoma c.530C>T p.P177L 17:7675082-7675082 9
16 COSM44096 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>G p.P250A 17:7674215-7674215 9
17 COSM45074 TP53 skin,NS,carcinoma,basal cell carcinoma c.829T>G p.C277G 17:7673791-7673791 9
18 COSM45739 TP53 skin,NS,carcinoma,basal cell carcinoma c.677G>C p.G226A 17:7674286-7674286 9
19 COSM10728 TP53 skin,NS,carcinoma,basal cell carcinoma c.839G>A p.R280K 17:7673781-7673781 9
20 COSM10656 TP53 skin,NS,carcinoma,basal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 9
21 COSM44606 TP53 skin,NS,carcinoma,basal cell carcinoma c.665C>T p.P222L 17:7674866-7674866 9
22 COSM44295 TP53 skin,NS,carcinoma,basal cell carcinoma c.993+1G>A p.? 17:7673534-7673534 9
23 COSM43778 TP53 skin,NS,carcinoma,basal cell carcinoma c.713G>T p.C238F 17:7674250-7674250 9
24 COSM10939 TP53 skin,NS,carcinoma,basal cell carcinoma c.832C>T p.P278S 17:7673788-7673788 9
25 COSM10650 TP53 skin,NS,carcinoma,basal cell carcinoma c.529C>T p.P177S 17:7675083-7675083 9
26 COSM43665 TP53 skin,NS,carcinoma,basal cell carcinoma c.746G>C p.R249T 17:7674217-7674217 9
27 COSM10662 TP53 skin,NS,carcinoma,basal cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 9
28 COSM45774 TP53 skin,NS,carcinoma,basal cell carcinoma c.899C>G p.P300R 17:7673721-7673721 9
29 COSM10749 TP53 skin,NS,carcinoma,basal cell carcinoma c.830G>T p.C277F 17:7673790-7673790 9
30 COSM11449 TP53 skin,NS,carcinoma,basal cell carcinoma c.388C>T p.L130F 17:7675224-7675224 9
31 COSM10660 TP53 skin,NS,carcinoma,basal cell carcinoma c.818G>A p.R273H 17:7673802-7673802 9
32 COSM10771 TP53 skin,NS,carcinoma,basal cell carcinoma c.749C>T p.P250L 17:7674214-7674214 9
33 COSM44068 TP53 skin,NS,carcinoma,basal cell carcinoma c.532C>A p.H178N 17:7675080-7675080 9
34 COSM11152 TP53 skin,NS,carcinoma,basal cell carcinoma c.700T>C p.Y234H 17:7674263-7674263 9
35 COSM43582 TP53 skin,NS,carcinoma,basal cell carcinoma c.454C>T p.P152S 17:7675158-7675158 9
36 COSM10768 TP53 skin,NS,carcinoma,basal cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 9
37 COSM45834 TP53 skin,NS,carcinoma,basal cell carcinoma c.409C>A p.L137M 17:7675203-7675203 9
38 COSM10905 TP53 skin,NS,carcinoma,basal cell carcinoma c.451C>T p.P151S 17:7675161-7675161 9
39 COSM10654 TP53 skin,NS,carcinoma,basal cell carcinoma c.637C>T p.R213* 17:7674894-7674894 9
40 COSM6932 TP53 skin,NS,carcinoma,basal cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
41 COSM10648 TP53 skin,NS,carcinoma,basal cell carcinoma c.524G>A p.R175H 17:7675088-7675088 9
42 COSM45424 TP53 skin,NS,carcinoma,basal cell carcinoma c.781A>T p.S261C 17:7674182-7674182 9
43 COSM10812 TP53 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.S241F 17:7674241-7674241 9
44 COSM10659 TP53 skin,NS,carcinoma,basal cell carcinoma c.817C>T p.R273C 17:7673803-7673803 9
45 COSM10794 TP53 skin,NS,carcinoma,basal cell carcinoma c.796G>A p.G266R 17:7673824-7673824 9
46 COSM44552 TP53 skin,NS,carcinoma,basal cell carcinoma c.509C>T p.T170M 17:7675103-7675103 9
47 COSM10704 TP53 skin,NS,carcinoma,basal cell carcinoma c.844C>T p.R282W 17:7673776-7673776 9
48 COSM10726 TP53 skin,NS,carcinoma,basal cell carcinoma c.856G>A p.E286K 17:7673764-7673764 9
49 COSM6549 TP53 skin,NS,carcinoma,basal cell carcinoma c.743G>T p.R248L 17:7674220-7674220 9
50 COSM45304 TP53 skin,NS,carcinoma,basal cell carcinoma c.375+1G>A p.? 17:7675993-7675993 9

Expression for Adenoid Basal Cell Carcinoma

Search GEO for disease gene expression data for Adenoid Basal Cell Carcinoma.

Pathways for Adenoid Basal Cell Carcinoma

Pathways related to Adenoid Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 CDKN2A ESR1 KIT PGR
2
Show member pathways
11.58 CDKN2A ESR1 PGR
3 10.86 CEACAM5 KIT SPN

GO Terms for Adenoid Basal Cell Carcinoma

Cellular components related to Adenoid Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 B2M CEACAM5 KIT SPN

Biological processes related to Adenoid Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stem cell differentiation GO:0048863 9.26 ESR1 KIT
2 response to cadmium ion GO:0046686 9.16 B2M KIT
3 positive regulation of phospholipase C activity GO:0010863 8.96 ESR1 KIT
4 somatic stem cell division GO:0048103 8.62 CDKN2A KIT

Molecular functions related to Adenoid Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
2 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Adenoid Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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