MCID: ADN015
MIFTS: 30

Adenoid Basal Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Adenoid Basal Cell Carcinoma

MalaCards integrated aliases for Adenoid Basal Cell Carcinoma:

Name: Adenoid Basal Cell Carcinoma 12 15
Skin Adenoid Basal Cell Carcinoma 12
Basal Cell Carcinoma - Adenoid 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4294
UMLS 73 C1304296

Summaries for Adenoid Basal Cell Carcinoma

MalaCards based summary : Adenoid Basal Cell Carcinoma, also known as skin adenoid basal cell carcinoma, is related to cutaneous adenocystic carcinoma and jejunal cancer. An important gene associated with Adenoid Basal Cell Carcinoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Gastric cancer and Cell cycle Role of SCF complex in cell cycle regulation. Affiliated tissues include skin and salivary gland, and related phenotypes are endocrine/exocrine gland and integument

Related Diseases for Adenoid Basal Cell Carcinoma

Diseases related to Adenoid Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 cutaneous adenocystic carcinoma 28.5 B2M CEACAM5 KRT7 LALBA
2 jejunal cancer 10.8 KIT KRT7
3 intratubular embryonal carcinoma 10.7 KIT KRT7
4 kidney benign neoplasm 10.7 KIT KRT7
5 pleomorphic carcinoma 10.7 KIT KRT7
6 benign breast phyllodes tumor 10.7 KIT PGR
7 breast angiosarcoma 10.6 KIT PGR
8 uterine body mixed cancer 10.6 KIT PGR
9 cystic nephroma 10.6 KIT PGR
10 perivascular epithelioid cell tumor 10.6 KIT PGR
11 functional colonic disease 10.6 B2M KIT
12 large cell neuroendocrine carcinoma 10.6 KIT KRT7
13 papillary hidradenoma 10.6 KIT PGR
14 liver leiomyoma 10.6 CEACAM5 KIT
15 endosalpingiosis 10.6 KRT7 PGR
16 spindle cell synovial sarcoma 10.6 KIT KRT7
17 female reproductive endometrioid cancer 10.6 KRT7 PGR
18 fox-fordyce disease 10.6 CEACAM5 KIT
19 benign metastasizing leiomyoma 10.6 KRT7 PGR
20 renal oncocytoma 10.6 KIT KRT7
21 corneal abscess 10.6 KRT7 PGR
22 papillary serous adenocarcinoma 10.6 KRT7 PGR
23 aggressive digital papillary adenocarcinoma 10.6 CEACAM5 KIT
24 acral lentiginous melanoma 10.6 CDKN2A KIT
25 rete testis adenocarcinoma 10.5 CEACAM5 KIT
26 sertoli-leydig cell tumor 10.5 KRT7 PGR
27 warthin tumor 10.5 CEACAM5 KIT
28 cutaneous mucoepidermoid carcinoma 10.5 CEACAM5 KRT7
29 anal gland adenocarcinoma 10.5 CEACAM5 KRT7
30 inverted transitional papilloma 10.5 CDKN2A KRT7
31 dysgerminoma of ovary 10.5 KIT PGR
32 ovarian cystic teratoma 10.5 B2M KRT7
33 anus adenocarcinoma 10.5 CEACAM5 KRT7
34 non-gestational choriocarcinoma 10.5 B2M PGR
35 malignant spiradenoma 10.5 CEACAM5 KRT7
36 bile duct mucoepidermoid carcinoma 10.5 CEACAM5 KRT7
37 mucinous bronchioloalveolar adenocarcinoma 10.5 CDKN2A KRT7
38 nodular hidradenoma 10.5 CEACAM5 KRT7
39 bile duct cystadenocarcinoma 10.5 CEACAM5 KRT7
40 bladder carcinoma in situ 10.5 CDKN2A KRT7
41 rete testis neoplasm 10.5 CEACAM5 KIT
42 thymus adenocarcinoma 10.5 CEACAM5 KRT7
43 meibomian cyst 10.5 CEACAM5 KRT7
44 colonic pseudo-obstruction 10.5 B2M KIT
45 cecum adenocarcinoma 10.5 B2M KRT7
46 nasal cavity adenocarcinoma 10.5 CDKN2A KRT7
47 ewing's family of tumors 10.5 CDKN2A KIT
48 mucinous ovarian cystadenoma 10.5 CEACAM5 KRT7
49 extragonadal seminoma 10.5 CEACAM5 KIT
50 rectum adenocarcinoma 10.5 CEACAM5 KRT7

Graphical network of the top 20 diseases related to Adenoid Basal Cell Carcinoma:



Diseases related to Adenoid Basal Cell Carcinoma

Symptoms & Phenotypes for Adenoid Basal Cell Carcinoma

MGI Mouse Phenotypes related to Adenoid Basal Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 ESR1 KIT LALBA PGR B2M CDKN2A
2 integument MP:0010771 9.43 ESR1 KIT LALBA PGR B2M CDKN2A
3 neoplasm MP:0002006 9.1 KIT PGR SPN B2M CDKN2A ESR1

Drugs & Therapeutics for Adenoid Basal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Adenoid Basal Cell Carcinoma

Genetic Tests for Adenoid Basal Cell Carcinoma

Anatomical Context for Adenoid Basal Cell Carcinoma

MalaCards organs/tissues related to Adenoid Basal Cell Carcinoma:

41
Skin, Salivary Gland

Publications for Adenoid Basal Cell Carcinoma

Articles related to Adenoid Basal Cell Carcinoma:

# Title Authors Year
1
Adenoid basal cell carcinoma: a rare facet of basal cell carcinoma. ( 27095806 )
2016
2
CD117 and CD43 are useful adjuncts in the distinction of adenoid cystic carcinoma from adenoid basal cell carcinoma. ( 25551301 )
2015
3
Coexistence of Solid (Nodular) and Differentiated (Adenoid) Basal Cell Carcinoma at the Same Anatomical Site. ( 26538745 )
2015
4
Adenoid basal cell carcinoma and its mimics. ( 23723508 )
2013
5
Adenoid Basal cell carcinoma simulating ameloblastoma. ( 19549180 )
2009
6
A Case of Axillary Adenoid Basal Cell Carcinoma. ( 27303153 )
2008
7
Tenascin expression in adenoid basal cell carcinoma of the skin. ( 8615597 )
1996
8
Giant adenoid basal cell carcinoma. ( 8060083 )
1994
9
Primary adenoid cystic carcinoma of the skin. A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma. ( 3010759 )
1986
10
Adenoid basal cell carcinoma of the vulva. ( 7185765 )
1982

Variations for Adenoid Basal Cell Carcinoma

Cosmic variations for Adenoid Basal Cell Carcinoma:

9
(show top 50) (show all 687)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6926860 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 9
2 COSM6926861 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 9
3 COSM6969201 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 9
4 COSM6953811 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 9
5 COSM6926862 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 9
6 COSM6936924 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 9
7 COSM3691166 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 9
8 COSM212945 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 9
9 COSM6953809 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 9
10 COSM6936922 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 9
11 COSM6926855 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 9
12 COSM6912933 TRAF7 skin,NS,carcinoma,basal cell carcinoma c.1802C>T p.T601I 16:2176104-2176104 9
13 COSM6949578 TP63 skin,NS,carcinoma,basal cell carcinoma c.1922C>T p.A641V 3:189894381-189894381 9
14 COSM44071 TP53 skin,NS,carcinoma,basal cell carcinoma c.955A>G p.K319E 17:7673573-7673573 9
15 COSM44097 TP53 skin,NS,carcinoma,basal cell carcinoma c.530C>T p.P177L 17:7675082-7675082 9
16 COSM44096 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>G p.P250A 17:7674215-7674215 9
17 COSM10728 TP53 skin,NS,carcinoma,basal cell carcinoma c.839G>A p.R280K 17:7673781-7673781 9
18 COSM45169 TP53 skin,NS,carcinoma,basal cell carcinoma c.326T>C p.F109S 17:7676043-7676043 9
19 COSM43842 TP53 skin,NS,carcinoma,basal cell carcinoma c.770T>C p.L257P 17:7674193-7674193 9
20 COSM43695 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>T p.P250S 17:7674215-7674215 9
21 COSM10988 TP53 skin,NS,carcinoma,basal cell carcinoma c.772G>A p.E258K 17:7674191-7674191 9
22 COSM45739 TP53 skin,NS,carcinoma,basal cell carcinoma c.677G>C p.G226A 17:7674286-7674286 9
23 COSM44295 TP53 skin,NS,carcinoma,basal cell carcinoma c.993+1G>A p.? 17:7673534-7673534 9
24 COSM43778 TP53 skin,NS,carcinoma,basal cell carcinoma c.713G>T p.C238F 17:7674250-7674250 9
25 COSM10939 TP53 skin,NS,carcinoma,basal cell carcinoma c.832C>T p.P278S 17:7673788-7673788 9
26 COSM10650 TP53 skin,NS,carcinoma,basal cell carcinoma c.529C>T p.P177S 17:7675083-7675083 9
27 COSM43665 TP53 skin,NS,carcinoma,basal cell carcinoma c.746G>C p.R249T 17:7674217-7674217 9
28 COSM10662 TP53 skin,NS,carcinoma,basal cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 9
29 COSM45774 TP53 skin,NS,carcinoma,basal cell carcinoma c.899C>G p.P300R 17:7673721-7673721 9
30 COSM10749 TP53 skin,NS,carcinoma,basal cell carcinoma c.830G>T p.C277F 17:7673790-7673790 9
31 COSM11449 TP53 skin,NS,carcinoma,basal cell carcinoma c.388C>T p.L130F 17:7675224-7675224 9
32 COSM10660 TP53 skin,NS,carcinoma,basal cell carcinoma c.818G>A p.R273H 17:7673802-7673802 9
33 COSM10771 TP53 skin,NS,carcinoma,basal cell carcinoma c.749C>T p.P250L 17:7674214-7674214 9
34 COSM44068 TP53 skin,NS,carcinoma,basal cell carcinoma c.532C>A p.H178N 17:7675080-7675080 9
35 COSM11152 TP53 skin,NS,carcinoma,basal cell carcinoma c.700T>C p.Y234H 17:7674263-7674263 9
36 COSM43582 TP53 skin,NS,carcinoma,basal cell carcinoma c.454C>T p.P152S 17:7675158-7675158 9
37 COSM10768 TP53 skin,NS,carcinoma,basal cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 9
38 COSM45834 TP53 skin,NS,carcinoma,basal cell carcinoma c.409C>A p.L137M 17:7675203-7675203 9
39 COSM10905 TP53 skin,NS,carcinoma,basal cell carcinoma c.451C>T p.P151S 17:7675161-7675161 9
40 COSM10654 TP53 skin,NS,carcinoma,basal cell carcinoma c.637C>T p.R213* 17:7674894-7674894 9
41 COSM6932 TP53 skin,NS,carcinoma,basal cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
42 COSM10648 TP53 skin,NS,carcinoma,basal cell carcinoma c.524G>A p.R175H 17:7675088-7675088 9
43 COSM45424 TP53 skin,NS,carcinoma,basal cell carcinoma c.781A>T p.S261C 17:7674182-7674182 9
44 COSM10812 TP53 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.S241F 17:7674241-7674241 9
45 COSM10656 TP53 skin,NS,carcinoma,basal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 9
46 COSM10659 TP53 skin,NS,carcinoma,basal cell carcinoma c.817C>T p.R273C 17:7673803-7673803 9
47 COSM10794 TP53 skin,NS,carcinoma,basal cell carcinoma c.796G>A p.G266R 17:7673824-7673824 9
48 COSM44552 TP53 skin,NS,carcinoma,basal cell carcinoma c.509C>T p.T170M 17:7675103-7675103 9
49 COSM10704 TP53 skin,NS,carcinoma,basal cell carcinoma c.844C>T p.R282W 17:7673776-7673776 9
50 COSM10726 TP53 skin,NS,carcinoma,basal cell carcinoma c.856G>A p.E286K 17:7673764-7673764 9

Expression for Adenoid Basal Cell Carcinoma

Search GEO for disease gene expression data for Adenoid Basal Cell Carcinoma.

Pathways for Adenoid Basal Cell Carcinoma

Pathways related to Adenoid Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 CDKN2A ESR1 KIT PGR
2
Show member pathways
11.58 CDKN2A ESR1 PGR
3 10.86 CEACAM5 KIT SPN

GO Terms for Adenoid Basal Cell Carcinoma

Biological processes related to Adenoid Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stem cell differentiation GO:0048863 9.26 ESR1 KIT
2 response to cadmium ion GO:0046686 9.16 B2M KIT
3 somatic stem cell division GO:0048103 8.96 CDKN2A KIT
4 positive regulation of phospholipase C activity GO:0010863 8.62 ESR1 KIT

Molecular functions related to Adenoid Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
2 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Adenoid Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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