MCID: ADN067
MIFTS: 38

Adenoid Hypertrophy

Categories: Respiratory diseases

Aliases & Classifications for Adenoid Hypertrophy

MalaCards integrated aliases for Adenoid Hypertrophy:

Name: Adenoid Hypertrophy 12 15
Hypertrophy of Adenoids 70 32
Adenoidal Hypertrophy 12
Enlarged Adenoids 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060311
ICD9CM 34 474.12
SNOMED-CT 67 111591002
ICD10 32 J35.2
UMLS 70 C0149825

Summaries for Adenoid Hypertrophy

Disease Ontology : 12 An upper respiratory tract disease characterized by the unusual growth of the adenoid tonsil; has symptom snoring, has symptom hyponasality, has symptom otitis media with effusion, has symptom mouth breathing.

MalaCards based summary : Adenoid Hypertrophy, also known as hypertrophy of adenoids, is related to common cold and dermatitis, atopic. An important gene associated with Adenoid Hypertrophy is SCGB1D4 (Secretoglobin Family 1D Member 4), and among its related pathways/superpathways are Yersinia infection and IL12-mediated signaling events. The drugs Mannitol and Phenylephrine have been mentioned in the context of this disorder. Affiliated tissues include tonsil, thyroid and skin.

Wikipedia : 73 Adenoid hypertrophy (enlarged adenoids) is the unusual growth (hypertrophy) of the adenoid (pharyngeal... more...

Related Diseases for Adenoid Hypertrophy

Diseases related to Adenoid Hypertrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 284)
# Related Disease Score Top Affiliating Genes
1 common cold 30.3 IL4 CYSLTR1 CD4
2 dermatitis, atopic 30.1 IL4 CYSLTR1 CD8A CD4
3 human immunodeficiency virus infectious disease 30.0 IL4 CD8A CD4
4 pfeiffer syndrome 29.7 CD8A CD4 CD19
5 middle ear disease 29.4 IL4 CD8A CD4 CD19
6 otitis media 10.7
7 allergic rhinitis 10.6
8 rhinitis 10.6
9 sleep apnea 10.5
10 ige responsiveness, atopic 10.3
11 asthma, nasal polyps, and aspirin intolerance 10.3 CYSLTR2 CYSLTR1
12 ophthalmomyiasis 10.3 SOD1 CD4
13 elephantiasis 10.3 IL4 CD4
14 eales disease 10.2 SOD1 IL4
15 tonsillitis 10.2
16 allergic disease 10.2
17 blepharoconjunctivitis 10.2 IL4 CD4
18 loiasis 10.2 IL4 CD4
19 mikulicz disease 10.2 IL4 CD4
20 cork-handlers' disease 10.2 CD8A CD4
21 necrotic uveal melanoma 10.2 CD8A CD4
22 early yaws 10.2 CD8A CD4
23 trichinosis 10.2 IL4 CD4
24 ventilation pneumonitis 10.2 CD8A CD4
25 diffuse infiltrative lymphocytosis syndrome 10.2 CD8A CD4
26 latent syphilis 10.2 CD8A CD4
27 type 1 diabetes mellitus 23 10.2 CD8A CD4
28 autoimmune lymphoproliferative syndrome, type iia 10.2 CD8A CD4
29 parapsoriasis 10.2 CD8A CD4
30 gastroduodenitis 10.2 CD8A CD4
31 duodenitis 10.2 CD8A CD4
32 primary syphilis 10.2 CD8A CD4
33 norwegian scabies 10.2 CD8A CD4
34 timothy grass allergy 10.2 IL4 CD4
35 bird fancier's lung 10.2 CD8A CD4
36 skin sarcoidosis 10.2 CD8A CD4
37 variola major 10.2 CD8A CD4
38 follicular mucinosis 10.2 CD8A CD4
39 mite infestation 10.2 IL4 CD4
40 tertiary syphilis 10.2 CD8A CD4
41 spongiotic dermatitis 10.2 CD8A CD4
42 acute retinal necrosis syndrome 10.2 CD8A CD4
43 oral tuberculosis 10.2 CD8A CD4
44 cerebritis 10.2 CD8A CD4
45 tungiasis 10.2 IL4 CD4
46 west nile encephalitis 10.2 CD8A CD4
47 granulomatous hepatitis 10.2 CD8A CD4
48 intrinsic asthma 10.2 IL4 CD4
49 exanthema subitum 10.2 CD8A CD4
50 immunodeficiency 36 10.2 CD8A CD4

Graphical network of the top 20 diseases related to Adenoid Hypertrophy:



Diseases related to Adenoid Hypertrophy

Symptoms & Phenotypes for Adenoid Hypertrophy

Drugs & Therapeutics for Adenoid Hypertrophy

Drugs for Adenoid Hypertrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
2
Phenylephrine Approved Phase 4 59-42-7 6041
3
Ephedrine Approved Phase 4 299-42-3 9294
4
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
5
Pseudoephedrine Approved Phase 4 90-82-4 7028
6
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
7
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
8
Propyl Gallate Investigational Phase 4 121-79-9 4947
9 Broncho-Vaxom Phase 4
10 Pharmaceutical Solutions Phase 4
11 Respiratory System Agents Phase 4
12 Adrenergic alpha-Agonists Phase 4
13 Cardiotonic Agents Phase 4
14 Nasal Decongestants Phase 4
15 Protective Agents Phase 4
16 Adrenergic Agents Phase 4
17 Adrenergic Agonists Phase 4
18 Mydriatics Phase 4
19 Sympathomimetics Phase 4
20 Neurotransmitter Agents Phase 4
21 Vasoconstrictor Agents Phase 4
22 Anti-Allergic Agents Phase 4
23 Anti-Inflammatory Agents Phase 4
24 Dermatologic Agents Phase 4
25
Acetaminophen Approved Phase 2 103-90-2 1983
26
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
27
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 68602 5311068
28
Dextromethorphan Approved Phase 2 125-71-3 5360696 5362449
29
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 2 14838-15-4 26934
30
Ketamine Approved, Vet_approved Phase 2 6740-88-1 3821
31 Anesthetics Phase 2
32 Anesthetics, General Phase 2
33 Hypnotics and Sedatives Phase 2
34 Chlorpheniramine, phenylpropanolamine drug combination Phase 2
35 Anesthetics, Dissociative Phase 2
36 Analgesics, Non-Narcotic Phase 2
37 Excitatory Amino Acid Antagonists Phase 2
38 Anesthetics, Intravenous Phase 2
39 Antitussive Agents Phase 2
40 Antipyretics Phase 2
41 Analgesics Phase 2
42
Formaldehyde Approved, Vet_approved 50-00-0 712
43 Immunoglobulins
44 Antibodies

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Effect of Vaxoral® (OM-85) on Frequency of Respiratory Tract Infections and Size of Adenoid Tissue in Preschool Children With Adenoid Hypertrophy Unknown status NCT03243565 Phase 4
2 A Multi-Center, Open-Label Study Evaluating Safety and Clinical Outcomes in Hunter Syndrome Patients 5 Years of Age and Younger Receiving Idursulfase Enzyme Replacement Therapy Completed NCT00607386 Phase 4
3 Combination Therapy With Mometasone Furoate and Oxymetazoline in the Treatment of Adenoid Hypertrophy Concomitant With Allergic Rhinitis Completed NCT02559440 Phase 4 mometasone furoate;Placebo;Oxymetazoline + Placebo;Placebo + placebo;mometasone furoate + Placebo;mometasone furoate + Oxymetazoline
4 Open Label Pilot Trial, Evaluating the Role of Nasonex in the Management of Nasal Obstruction Secondary to Adenoids Hypertrophy in Children Completed NCT01098071 Phase 4 mometasone furoate nasal spray
5 Double Blind, Placebo Controlled Trial, Evaluating the Role of Nasonex® in the Management of Nasal Obstruction Secondary to Adenoids Hypertrophy in Children Terminated NCT00553891 Phase 4 mometasone furoate nasal spray;placebo nasal spray
6 An Open-Label Extension of Study TKT024 Evaluating Long-Term Safety and Clinical Outcomes in MPS II Patients Receiving Iduronate-2-Sulfatase Enzyme Replacement Therapy Completed NCT00630747 Phase 2, Phase 3
7 A Controlled, Randomized, Two-arm, Open-label, Assessor-blinded, Multicenter Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment Completed NCT02055118 Phase 2, Phase 3
8 A Double-blind Placebo-controlled, Randomized, Parallel-group, Multicenter Clinical Trial to Evaluate Efficacy and Safety of Mometasone Furoate Nasal Spray in Children With Adenoid Hypertrophy SNORE Study Completed NCT00552032 Phase 3 Mometasone Furoate nasal spray;Placebo
9 A Phase I/II, Randomized, Safety and Ascending Dose Ranging Study of Intrathecal Idursulfase-IT Administered in Conjunction With Intravenous Elaprase in Pediatric Patients With Hunter Syndrome and Cognitive Impairment Completed NCT00920647 Phase 1, Phase 2 Idursulfase IT (1 mg);Idursulfase IT (10 mg);Idursulfase IT (30 mg)
10 A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients Completed NCT03714919 Phase 2 Dextromethorphan;Acetaminophen;Dexmedetomidine;Ketamine
11 Adenoidectomy, Myringotomy and Tubes' Insertion vs Adenoidectomy and Myringotomy Alone in Children With Otitis Media With Effusion and Adenoid Hypertrophy Completed NCT00629694 Phase 2
12 An Open-Label Extension of Study HGT-HIT-045 Evaluating Long-Term Safety and Clinical Outcomes of Intrathecal Idursulfase-IT Administered in Conjunction With Intravenous Elaprase® in Pediatric Patients With Hunter Syndrome and Cognitive Impairment Active, not recruiting NCT01506141 Phase 1, Phase 2 Idursulfase-IT;Elaprase
13 The Influence of Feeding Position on Pulmonary Morbidity in Young Children Unknown status NCT00248391
14 Assesment of Adenoid Size by Flexible Nasoendoscopy and Lateral Neck Radiography and Its Relation to Clinical Symptoms Unknown status NCT03890692
15 The Correlation Between Adenoid Hypertrophy and Body Temperature in Children Before and After Adenoidectomy Unknown status NCT02965183
16 Assessment of Adenoidal Obstruction in Children : Clinical Signs Versus Flexible Nasal Endoscopy and Roentgenographic Findings Completed NCT01965457
17 A Multi-Center Observational Study Evaluating Anti-Idursulfase Serum Antibody Response in Hunter Syndrome Patients Enrolled in the Hunter Outcome Survey (HOS) Receiving Idursulfase Enzyme Replacement Therapy Completed NCT00882921
18 Adenoid Hypertrophy, Etiology, Clinical Manifestations and Related Morbidity, Correlation With Infant Feeding Position Completed NCT04431128
19 Periostin Levels in Children With Adenoid Hypertrophy Completed NCT04152746
20 Relationship Between Apoptosis and er Stress in Chronic Adenoiditis and Adenoid Hypertrophy Completed NCT04583631
21 Use of Sleep Endoscopy to Predict Outcomes of Pediatric Adenotonsillectomy Enrolling by invitation NCT02693977
22 Comparison of Short and Long-term Results of Conventional Curettage Adenoidectomy Without Endoscopy Assistance Versus Curettage Adenoidectomy With Transoral Endoscopic Residue Ablation in Children Not yet recruiting NCT04302337
23 Comparison Between the Fate of Secretory Otitis Media in Patients With Adenoids Hypertrophy Undergoing Adenoidectomy Alone or With Myringotomy or With Myringotomy and Tympanostomy Tube Application Not yet recruiting NCT04584073
24 Evaluation the Neurocognitive Functions Among Children With Enlargement Adenoid and Tonsils, Before and After Tonsillectomy or Adenotonsillectomy Not yet recruiting NCT04197518

Search NIH Clinical Center for Adenoid Hypertrophy

Genetic Tests for Adenoid Hypertrophy

Anatomical Context for Adenoid Hypertrophy

MalaCards organs/tissues related to Adenoid Hypertrophy:

40
Tonsil, Thyroid, Skin, Bone, Lung, Neutrophil, Eye

Publications for Adenoid Hypertrophy

Articles related to Adenoid Hypertrophy:

(show top 50) (show all 617)
# Title Authors PMID Year
1
Correlation Between Adenoid Hypertrophy, Tympanometry Findings, and Viscosity of Middle Ear Fluid in Chronic Otitis Media With Effusion, Southern Oman. 61
31547716 2021
2
Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy. 61
33679914 2021
3
IL-32 exacerbates adenoid hypertrophy via activating NLRP3-mediated cell pyroptosis, which promotes inflammation. 61
33495843 2021
4
Hypoxia activates SUMO-1-HIF-1α signaling pathway to upregulate pro-inflammatory cytokines and permeability in human tonsil epithelial cells. 61
33794253 2021
5
Adjunctive Treatment of Pediatric Adenoidal Hypertrophy: A Review. 61
33711820 2021
6
Novel compound heterozygous mutations of PCNT gene in MOPD type II with central precocious puberty. 61
33016782 2021
7
Hypoxia induced factor-1α levels in patients undergoing adenoidectomy. 61
33226863 2021
8
Nasal ventilation and rapid maxillary expansion (RME): a randomized trial. 61
33564835 2021
9
Serologic false-positive reactions for syphilis in children of adenoidal hypertrophy:2 case reports and review of the literature. 61
31368864 2021
10
Rising Resonance Frequency Is the Sole Sign of Early Middle Ear Disease in Children With Adenoid Hypertrophy. 61
33625192 2021
11
The Prevalence of Adenoid Hypertrophy among Children with Zika Related Microcephaly. 61
33466404 2021
12
Eustachian Tube Dysfunction in Children With Adenoid Hypertrophy: The Role of Adenoidectomy for Improving Ear Ventilation. 61
33470833 2021
13
The microbiome of pediatric patients with chronic rhinosinusitis. 61
32348024 2021
14
The P.E.A.N.U.T. Method: Update on an Integrative System Approach for the Treatment of Chronic Otitis Media with Effusion and Adenoid Hypertrophy in Children. 61
33573118 2021
15
Adenoidectomy: Anatomical variables as predictive factors of intraoperative adenoid residues. 61
33199030 2021
16
Otitis media with effusion in Africa-prevalence and associated factors: A systematic review and meta-analysis. 61
33364413 2020
17
Frequency of gastroesophageal reflux disease in children with adenoid hypertrophy. 61
32828019 2020
18
Obstructive sleep apnea in children aged 3 years and younger: Rate and risk factors. 61
33173554 2020
19
Chronic adenoiditis. 61
33251901 2020
20
Trans-oral endoscopic assisted radio-frequency for adenoid ablation; A randomized prospective comparative clinical study. 61
33261981 2020
21
Novel Use of Ultrasound in Evaluation of Adenoid Hypertrophy in Children. 61
32910335 2020
22
Montelukast combined with intranasal mometasone furoate versus intranasal mometasone furoate; a comparative study in treatment of adenoid hypertrophy. 61
32950830 2020
23
Predicting the outcome after adenoidectomy-alone for adenoid hypertrophy causing sleep disordered breathing. 61
32688182 2020
24
Benign adenoidal hypertrophy caused by adenovirus presenting as a nasopharyngeal mass concerning for malignancy. 61
32823205 2020
25
Copy number variation, gene expression and histological localization of human beta-defensin 2 in patients with adeno-tonsillar hypertrophy. 61
32551953 2020
26
Evaluation of Adenoid Hypertrophy with Ultrasonography. 61
32193786 2020
27
Comparison of middle ear function and hearing thresholds in children with adenoid hypertrophy after microdebrider and conventional adenoidectomy: a randomised controlled trial. 61
32666291 2020
28
The current state and future prospects of the fundamental research on pediatric otorhinolaryngology: an analysis of application and funding data of the National Natural Science Foundation of China from 2009 to 2019. 61
33209867 2020
29
The Relation of Allergy to Adenoid Hypertrophy and Otitis Media with Effusion: A Cross-sectional Study. 61
33463120 2020
30
Vascular endothelial growth factor and transforming growth factor β in hypertrophic adenoids in children suffering from otitis media with effusion. 61
32438279 2020
31
[Comparison and intervention of differences in upper airway obstruction in children with OSAS between awake and asleep]. 61
32842204 2020
32
Risk Factors for Otitis Media in Children Referred to Abuzar Hospital in Ahvaz: A Case-Control Study. 61
32944478 2020
33
[Study on the relationship between adenoid and tonsil hypertrophy and obesity in children]. 61
32791774 2020
34
Comparison of adenoid assessment by flexible endoscopy and mirror exam. 61
32371357 2020
35
Comparison of Endoscope-Assisted Coblation Adenoidectomy to Conventional Curettage Adenoidectomy in Terms of Postoperative Eustachian Tube Function. 61
31764564 2020
36
A deep-learning-based approach for adenoid hypertrophy diagnosis. 61
32017124 2020
37
[The efficacy of OM85-BV in the treatment of recurrent upper respiratory tract infection with adenoid hypertrophy and the preliminary exploration of potential therapeutic mechanism]. 61
32842178 2020
38
Mometasone furoate intranasal spray is effective in reducing symptoms and adenoid size in children and adolescents with adenoid hypertrophy. 61
31400807 2020
39
Lateral Neck Radiography in Preoperative Evaluation of Adenoid Hypertrophy. 61
31868005 2020
40
Lifestyle-related factors differentiating the prevalence of otorhinolaryngological diseases among 6-17-year-olds from Wrocław, Poland. 61
32058158 2020
41
Myringotomy and tube insertion combined with balloon eustachian tuboplasty for the treatment of otitis media with effusion in children. 61
32002612 2020
42
Risk factors for otitis media with effusion in children with adenoid hypertrophy. 61
32469007 2020
43
Risk factors of obstructive sleep apnea syndrome in children. 61
32131901 2020
44
[Myringotomy or tympanostomy tube insertion, comparison of surgical treatment of adenoid hypertrophy and otitis media with effusion in children]. 61
32791583 2020
45
Partial resection of hypertrophic torus tubarius for recurred snoring: Case series. 61
32150069 2020
46
Correlation Between Microbiological Profiles of Adenoid Tissue and Nasal Discharge in Children with Co-existent Chronic Adenoiditis and Chronic Rhinosinusitis. 61
32158666 2020
47
Ciliary beat frequency in children with adenoid hypertrophy. 61
31917900 2020
48
The cost-effectiveness analysis of drug therapy versus surgery for symptomatic adenoid hypertrophy by a Markov model. 61
31782019 2020
49
Development, validation and application of a 3D printed model depicting adenoid hypertrophy in comparison to a Nasoendoscopy. 61
32151261 2020
50
Tonsil volume may predict adenoid size: a real-life study. 61
32073566 2020

Variations for Adenoid Hypertrophy

Expression for Adenoid Hypertrophy

Search GEO for disease gene expression data for Adenoid Hypertrophy.

Pathways for Adenoid Hypertrophy

Pathways related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.72 ELMO2 CD8A CD4
2
Show member pathways
11.6 IL4 CD8A CD4
3 11.4 IL4 CD8A CD4
4 11.32 IL4 CD8A CD4 CD19
5 11.3 CD8A CD4 CD19
6 10.92 IL4 CD8A CD4 CD19
7 10.91 CD8A CD4 CD19
8 10.9 IL4 CD4

GO Terms for Adenoid Hypertrophy

Cellular components related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.1 VSIG10 CYSLTR2 CYSLTR1 CD8A CD4 CD19

Biological processes related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.56 IL4 CYSLTR2 CD8A CD4
2 positive regulation of myoblast fusion GO:1901741 9.16 SCGB3A1 IL4
3 leukotriene signaling pathway GO:0061737 8.96 CYSLTR2 CYSLTR1
4 T cell activation GO:0042110 8.8 IL4 CD8A CD4

Molecular functions related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukotriene receptor activity GO:0004974 8.96 CYSLTR2 CYSLTR1
2 cysteinyl leukotriene receptor activity GO:0001631 8.62 CYSLTR2 CYSLTR1

Sources for Adenoid Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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