MCID: ADN067
MIFTS: 37

Adenoid Hypertrophy

Categories: Respiratory diseases

Aliases & Classifications for Adenoid Hypertrophy

MalaCards integrated aliases for Adenoid Hypertrophy:

Name: Adenoid Hypertrophy 12 15
Hypertrophy of Adenoids 74
Adenoidal Hypertrophy 12
Enlarged Adenoids 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060311
ICD9CM 36 474.12
ICD10 34 J35.2
UMLS 74 C0149825

Summaries for Adenoid Hypertrophy

Disease Ontology : 12 An upper respiratory tract disease characterized by the unusual growth of the adenoid tonsil; has symptom snoring, has symptom hyponasality, has symptom otitis media with effusion, has symptom mouth breathing.

MalaCards based summary : Adenoid Hypertrophy, also known as hypertrophy of adenoids, is related to otitis media and muscle hypertrophy. An important gene associated with Adenoid Hypertrophy is CYSLTR1 (Cysteinyl Leukotriene Receptor 1), and among its related pathways/superpathways are Endothelins and Eicosanoid ligand-binding receptors. The drugs Sufentanil and Pseudoephedrine have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and heart.

Wikipedia : 77 Adenoid hypertrophy (enlarged adenoids) is the unusual growth (hypertrophy) of the adenoid (pharyngeal... more...

Related Diseases for Adenoid Hypertrophy

Graphical network of the top 20 diseases related to Adenoid Hypertrophy:



Diseases related to Adenoid Hypertrophy

Symptoms & Phenotypes for Adenoid Hypertrophy

Drugs & Therapeutics for Adenoid Hypertrophy

Drugs for Adenoid Hypertrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
2
Pseudoephedrine Approved Phase 4 90-82-4 7028
3
Oxymetazoline Approved, Investigational Phase 4,Not Applicable 1491-59-4 4636
4
mometasone furoate Approved, Investigational, Vet_approved Phase 4,Phase 3 83919-23-7
5
Phenylephrine Approved Phase 4,Not Applicable 59-42-7 6041
6
Ephedrine Approved Phase 4 299-42-3 9294
7
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
8
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
9
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
10
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
11
Propyl Gallate Investigational Phase 4 121-79-9 4947
12 Central Nervous System Depressants Phase 4,Phase 2
13 Peripheral Nervous System Agents Phase 4,Phase 2
14 Analgesics, Opioid Phase 4
15 Anesthetics Phase 4,Phase 2,Not Applicable
16 Anesthetics, Intravenous Phase 4,Phase 2
17 Narcotics Phase 4
18 Adjuvants, Anesthesia Phase 4
19 Analgesics Phase 4,Phase 2
20 Anesthetics, General Phase 4,Phase 2
21 Dermatologic Agents Phase 4,Phase 3
22 Protective Agents Phase 4
23 Adrenergic Agents Phase 4,Phase 2
24 Respiratory System Agents Phase 4,Phase 2
25 Adrenergic alpha-Agonists Phase 4,Phase 2
26 Cardiotonic Agents Phase 4
27 Neurotransmitter Agents Phase 4,Phase 2
28 Sympathomimetics Phase 4
29 Adrenergic Agonists Phase 4,Phase 2
30 Vasoconstrictor Agents Phase 4
31 Autonomic Agents Phase 4
32 Nasal Decongestants Phase 4
33 Anti-Inflammatory Agents Phase 4,Phase 3
34 Anti-Allergic Agents Phase 4,Phase 3
35 Mydriatics Phase 4
36 Broncho-Vaxom Phase 4
37 Antacids Phase 4
38 Gastrointestinal Agents Phase 4
39 Proton Pump Inhibitors Phase 4
40 Anti-Ulcer Agents Phase 4
41
Ketamine Approved, Vet_approved Phase 2 6740-88-1 3821
42
Dextromethorphan Approved Phase 2 125-71-3 5362449 5360696
43
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
44
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 68602 5311068
45
Acetaminophen Approved Phase 2 103-90-2 1983
46 Chlorpheniramine, phenylpropanolamine drug combination Phase 2
47 Analgesics, Non-Narcotic Phase 2
48 Excitatory Amino Acids Phase 2
49 Hypnotics and Sedatives Phase 2
50 Antitussive Agents Phase 2

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
2 Mometasone Furoate and Oxymetazoline in the Treatment of Adenoid Hypertrophy Completed NCT02559440 Phase 4 mometasone furoate;Placebo;Oxymetazoline + Placebo;Placebo + placebo;mometasone furoate + Placebo;mometasone furoate + Oxymetazoline
3 Placebo-controlled Trial With Nasonex for Nasal Obstruction Secondary to Adenoids Hypertrophy in Children (P04367)(TERMINATED) Terminated NCT00553891 Phase 4 mometasone furoate nasal spray;placebo nasal spray
4 Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy Not yet recruiting NCT03243565 Phase 4
5 Nasonex (Mometasone Furoate Nasal Spray) in Adenoids Hypertrophy in Children (P04367) Completed NCT01098071 Phase 4 mometasone furoate nasal spray
6 Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children Completed NCT01082029 Phase 4 Lansoprazole;Placebo
7 Lidocaine Infusion for Pain Relief in Children Scheduled for Tonsillectomy and Adenoidectomy Not yet recruiting NCT03902314 Phase 4 Lidocaine Iv;Saline Solution
8 Efficacy and Safety of Mometasone Furoate Nasal Spray in Children With Adenoid Hypertrophy. SNORE Study (P05155) Completed NCT00552032 Phase 3 Mometasone Furoate nasal spray;Placebo
9 Adenoidectomy, Myringotomy and Tubes' Insertion vs Adenoidectomy and Myringotomy Alone in Children With Otitis Media With Effusion and Adenoid Hypertrophy Completed NCT00629694 Phase 2
10 A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients Enrolling by invitation NCT03714919 Phase 2 Dextromethorphan;Acetaminophen;Dexmedetomidine;Ketamine
11 The Correlation Between Adenoid Hypertrophy and Body Temperature in Children Before and After Adenoidectomy Unknown status NCT02965183 Not Applicable
12 The Influence of Feeding Position on Pulmonary Morbidity in Young Children Unknown status NCT00248391 Not Applicable
13 Methods of Assessment of Adenoid Size Not yet recruiting NCT03890692 Not Applicable
14 Assessment of Adenoidal Obstruction in Children : Clinical Signs Versus Flexible Nasal Endoscopy and Roentgenographic Findings Completed NCT01965457
15 Surgical Versus Nonsurgical Treatment on Quality of Life for Children With Controversial OSA Diagnoses Recruiting NCT03370731 Not Applicable
16 Use of Sleep Endoscopy to Predict Outcomes of Pediatric Adenotonsillectomy Enrolling by invitation NCT02693977
17 Interactive Perioperative Teaching Platform (IPTP) Recruiting NCT03677453 Not Applicable
18 Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population Active, not recruiting NCT03541434

Search NIH Clinical Center for Adenoid Hypertrophy

Genetic Tests for Adenoid Hypertrophy

Anatomical Context for Adenoid Hypertrophy

MalaCards organs/tissues related to Adenoid Hypertrophy:

42
Tonsil, Testes, Heart, Thyroid, Monocytes

Publications for Adenoid Hypertrophy

Articles related to Adenoid Hypertrophy:

(show top 50) (show all 131)
# Title Authors Year
1
Efficacy of Sublingual Administration of Dermatophagoides Farinae Drops for Treatment of Pediatric Allergic Rhinitis Accompanied by Adenoid Hypertrophy and Improvement of Immune Function. ( 30633736 )
2019
2
Accuracy of lateral cephalogram for diagnosis of adenoid hypertrophy and posterior upper airway obstruction: A meta-analysis. ( 30658139 )
2019
3
Effectiveness and safety of Chinese herbal medicine for pediatric adenoid hypertrophy: A meta-analysis. ( 30684690 )
2019
4
Reply to the letter to the author concerning: 'Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?' ( 29423746 )
2018
5
Innate immunity gene expression by epithelial cells of upper respiratory tract in children with adenoid hypertrophy. ( 29500040 )
2018
6
Evaluation of choroidal thickness in children with adenoid hypertrophy. ( 29313145 )
2018
7
Superficial punctate keratopathy in a pediatric patient was related to adenoid hypertrophy and obstructive sleep apnea syndrome: a case report. ( 29471795 )
2018
8
CYSLTR1 promotes adenoid hypertrophy by activating ERK1/2. ( 30116346 )
2018
9
The relationship between adenoid hypertrophy and gastroesophageal reflux disease: A meta-analysis. ( 30313042 )
2018
10
Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide. ( 30368395 )
2018
11
Halitosis in children with adenoid hypertrophy. ( 29146888 )
2017
12
Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: A randomized controlled trial. ( 28098165 )
2017
13
Significant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population. ( 28263490 )
2017
14
Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population. ( 28823693 )
2017
15
Prevalence of adenoid hypertrophy: A systematic review and meta-analysis. ( 29153763 )
2017
16
Myhre syndrome with novel findings: bilateral congenital cortical cataract, bilateral papilledema, accessory nipple, and adenoid hypertrophy. ( 28562390 )
2017
17
The pathogens profile in children with otitis media with effusion and adenoid hypertrophy. ( 28231295 )
2017
18
Correlation and reliability of cone-beam computed tomography nasopharyngeal volumetric and area measurements as determined by commercial software against nasopharyngoscopy-supported diagnosis of adenoid hypertrophy. ( 28651774 )
2017
19
Pre- and post-operative application of acoustic rhinometry in children with otitis media with effusion and with or without adenoid hypertrophy-a retrospective analysis. ( 29224765 )
2017
20
Adenoid hypertrophy in children and allergic rhinitis. ( 28887688 )
2017
21
The common genetic variants of toll-like receptor and susceptibilityto adenoid hypertrophy: a hospital-based cohort study. ( 27966312 )
2016
22
Accuracy and reliability of orthodontists using cone-beam computerized tomography for assessment of adenoid hypertrophy. ( 27871704 )
2016
23
Accuracy and reliability of oral maxillofacial radiologists when evaluating cone-beam computed tomography imaging for adenoid hypertrophy screening: a comparison with nasopharyngoscopy. ( 27181449 )
2016
24
The relationship of enuresis nocturna and adenoid hypertrophy. ( 27377086 )
2016
25
The effect of adenoid hypertrophy and adenoidectomy in patients on cardiovascular risk reduction. ( 27405084 )
2016
26
Integrative versus Conventional Therapy of Chronic Otitis Media with Effusion and Adenoid Hypertrophy in Children: A Prospective Observational Study. ( 27607438 )
2016
27
Community level evaluation of adenoid hypertrophy on the basis of symptom scoring and its X-ray correlation. ( 28348992 )
2016
28
Does adenoid hypertrophy affect disease severity in children with allergic rhinitis? ( 27405740 )
2016
29
Tympanometric Findings among Children with Adenoid Hypertrophy in Port Harcourt, Nigeria. ( 27563311 )
2016
30
The effect of adenoid hypertrophy on maxillofacial development: an objective photographic analysis. ( 27647047 )
2016
31
Cognitive event related potentials in patients with adenoid hypertrophy; a case control pilot study. ( 26808619 )
2016
32
Adenoid hypertrophy and chronic rhinosinusitis: Helicobacter pylori on antral lavages, adenoid tissue and salival inmunoglobuline A on paediatric patients. ( 26746618 )
2016
33
MRI of nasopharyngeal adenoid hypertrophy. ( 27531860 )
2016
34
Effect of adenoid hypertrophy and pulmonary function tests in children with mild asthma. ( 27888821 )
2016
35
Prevalence of Panton-Valentine leucocidin and phenotypic and genotypic characterization of biofilm formation among Staphylococcus aureus strains isolated from children with adenoid hypertrophy. ( 26476288 )
2015
36
Health-related quality of life among children with adenoid hypertrophy in Xi'an, China. ( 26553400 )
2015
37
Nasal Mucociliary Clearance in Adenoid Hypertrophy and Otitis Media with Effusion. ( 26496764 )
2015
38
Adenoid hypertrophy in children with allergic disease and influential factors. ( 25758194 )
2015
39
Possible role of apoptosis in pathogenesis of adenoid hypertrophy and chronic adenoiditis: Prospective case-control study. ( 26003878 )
2015
40
A new clinical scoring system for adenoid hypertrophy in children. ( 25745612 )
2015
41
Systematic review and meta-analysis of randomized controlled trials on the role of mometasone in adenoid hypertrophy in children. ( 26235732 )
2015
42
Evaluation of middle ear pressure in the early period after adenoidectomy in children with adenoid hypertrophy without otitis media with effusion. ( 25766622 )
2015
43
Chicken or the egg: the dilemma of allergic rhinitis versus adenoid hypertrophy. ( 26030038 )
2015
44
ALLERGIC RHINITIS AND ADENOID HYPERTROPHY IN CHILDREN: IS ADENOIDECTOMY ALWAYS REALLY USEFUL? ( 26634589 )
2015
45
Montelukast in Adenoid Hypertrophy: Its Effect on Size and Symptoms. ( 26788489 )
2015
46
Response to "Mean platelet volume may not be beneficial for the management of patients with adenoid hypertrophy". ( 25887209 )
2015
47
[Expression of CysLTR-1 and CysLTR-2 in adenoid tissues from children with adenoid hypertrophy]. ( 25760841 )
2015
48
Does atopy influence the effectiveness of treatment of adenoid hypertrophy with mometasone furoate? ( 25590321 )
2015
49
Relative etiological importance of adenoid hypertrophy versus sinusitis in children with persistent rhinorrhoea. ( 25621229 )
2015
50
The effect of adenoidectomy operation made on patients with adenoid hypertrophy on cardiovascular risk reduction. ( 25974805 )
2015

Variations for Adenoid Hypertrophy

Expression for Adenoid Hypertrophy

Search GEO for disease gene expression data for Adenoid Hypertrophy.

Pathways for Adenoid Hypertrophy

Pathways related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.68 CYSLTR1 CYSLTR2
2
Show member pathways
10.3 CYSLTR1 CYSLTR2

GO Terms for Adenoid Hypertrophy

Biological processes related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phosphorylation GO:0046854 9.16 CD19 IMPA1
2 neuropeptide signaling pathway GO:0007218 8.96 CYSLTR1 CYSLTR2
3 leukotriene signaling pathway GO:0061737 8.62 CYSLTR1 CYSLTR2

Molecular functions related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 ARNT2 CD19 CYSLTR1 CYSLTR2 ELMO2 IMPA1
2 G protein-coupled peptide receptor activity GO:0008528 9.16 CYSLTR1 CYSLTR2
3 galanin receptor activity GO:0004966 8.96 CYSLTR1 CYSLTR2
4 leukotriene receptor activity GO:0004974 8.62 CYSLTR1 CYSLTR2

Sources for Adenoid Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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