MCID: ADN067
MIFTS: 40

Adenoid Hypertrophy

Categories: Respiratory diseases

Aliases & Classifications for Adenoid Hypertrophy

MalaCards integrated aliases for Adenoid Hypertrophy:

Name: Adenoid Hypertrophy 12 15
Hypertrophy of Adenoids 73
Adenoidal Hypertrophy 12
Enlarged Adenoids 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060311
ICD10 33 J35.2
ICD9CM 35 474.12
UMLS 73 C0149825

Summaries for Adenoid Hypertrophy

Disease Ontology : 12 An upper respiratory tract disease characterized by the unusual growth of the adenoid tonsil; has symptom snoring, has symptom hyponasality, has symptom otitis media with effusion, has symptom mouth breathing.

MalaCards based summary : Adenoid Hypertrophy, also known as hypertrophy of adenoids, is related to rhinitis and otitis media. An important gene associated with Adenoid Hypertrophy is CYSLTR1 (Cysteinyl Leukotriene Receptor 1), and among its related pathways/superpathways are Endothelins and Eicosanoid ligand-binding receptors. The drugs Sufentanil and Phenylephrine have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and heart, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Adenoid hypertrophy (or enlarged adenoids) is the unusual growth (hypertrophy) of the adenoid... more...

Related Diseases for Adenoid Hypertrophy

Graphical network of the top 20 diseases related to Adenoid Hypertrophy:



Diseases related to Adenoid Hypertrophy

Symptoms & Phenotypes for Adenoid Hypertrophy

MGI Mouse Phenotypes related to Adenoid Hypertrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 CD19 CYSLTR1 CYSLTR2 KIF7 SOD1 TRPV1
2 cellular MP:0005384 9.1 ARNT2 CD19 CYSLTR1 KIF7 SOD1 TRPV1

Drugs & Therapeutics for Adenoid Hypertrophy

Drugs for Adenoid Hypertrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
2
Phenylephrine Approved Phase 4 59-42-7 6041
3
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
4
Ephedrine Approved Phase 4 299-42-3 9294
5
mometasone furoate Approved, Vet_approved Phase 4,Phase 3 83919-23-7
6
Pseudoephedrine Approved Phase 4 90-82-4 7028
7
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
8
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
9
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
10
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
11
Propyl Gallate Investigational Phase 4 121-79-9 4947
12 Anesthetics, General Phase 4,Phase 2
13 Central Nervous System Depressants Phase 4,Phase 2
14 Analgesics, Opioid Phase 4
15 Narcotics Phase 4
16 Analgesics Phase 4,Phase 2
17 Anesthetics, Intravenous Phase 4,Phase 2
18 Adjuvants, Anesthesia Phase 4
19 Peripheral Nervous System Agents Phase 4,Phase 2
20 Anesthetics Phase 4,Phase 2,Not Applicable
21 Anti-Allergic Agents Phase 4,Phase 3
22 Vasoconstrictor Agents Phase 4
23 Neurotransmitter Agents Phase 4,Phase 2
24 Adrenergic Agonists Phase 4,Phase 2
25 Nasal Decongestants Phase 4
26 Mydriatics Phase 4
27 Adrenergic alpha-Agonists Phase 4,Phase 2
28 Protective Agents Phase 4
29 Anti-Inflammatory Agents Phase 4,Phase 3
30 Dermatologic Agents Phase 4,Phase 3
31 Cardiotonic Agents Phase 4
32 Adrenergic Agents Phase 4,Phase 2
33 Respiratory System Agents Phase 4,Phase 2
34 Autonomic Agents Phase 4
35 Sympathomimetics Phase 4
36 Antacids Phase 4
37 Anti-Ulcer Agents Phase 4
38 Gastrointestinal Agents Phase 4
39 Proton Pump Inhibitors Phase 4
40 Broncho-Vaxom Phase 4
41
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 68602 5311068
42
Dextromethorphan Approved Phase 2 125-71-3 5360696 5362449
43
Ketamine Approved, Vet_approved Phase 2 6740-88-1 3821
44
Acetaminophen Approved Phase 2 103-90-2 1983
45
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
46 Anesthetics, Dissociative Phase 2
47 Hypnotics and Sedatives Phase 2
48 Antitussive Agents Phase 2
49 Adrenergic alpha-2 Receptor Agonists Phase 2
50 Chlorpheniramine, phenylpropanolamine drug combination Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
2 Mometasone Furoate and Oxymetazoline in the Treatment of Adenoid Hypertrophy Completed NCT02559440 Phase 4 mometasone furoate;Placebo;Oxymetazoline + Placebo;Placebo + placebo;mometasone furoate + Placebo;mometasone furoate + Oxymetazoline
3 Nasonex (Mometasone Furoate Nasal Spray) in Adenoids Hypertrophy in Children (P04367) Completed NCT01098071 Phase 4 mometasone furoate nasal spray
4 Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children Completed NCT01082029 Phase 4 Lansoprazole;Placebo
5 Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy Not yet recruiting NCT03243565 Phase 4
6 Placebo-controlled Trial With Nasonex for Nasal Obstruction Secondary to Adenoids Hypertrophy in Children (P04367)(TERMINATED) Terminated NCT00553891 Phase 4 mometasone furoate nasal spray;placebo nasal spray
7 Efficacy and Safety of Mometasone Furoate Nasal Spray in Children With Adenoid Hypertrophy. SNORE Study (P05155) Completed NCT00552032 Phase 3 Mometasone Furoate nasal spray;Placebo
8 Adenoidectomy, Myringotomy and Tubes' Insertion vs Adenoidectomy and Myringotomy Alone in Children With Otitis Media With Effusion and Adenoid Hypertrophy Completed NCT00629694 Phase 2
9 A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients Not yet recruiting NCT03714919 Phase 2 Dextromethorphan;Acetaminophen;Dexmedetomidine;Ketamine
10 The Correlation Between Adenoid Hypertrophy and Body Temperature in Children Before and After Adenoidectomy Unknown status NCT02965183 Not Applicable
11 The Influence of Feeding Position on Pulmonary Morbidity in Young Children Unknown status NCT00248391 Not Applicable
12 Assessment of Adenoidal Obstruction in Children : Clinical Signs Versus Flexible Nasal Endoscopy and Roentgenographic Findings Completed NCT01965457
13 Surgical Versus Nonsurgical Treatment on Quality of Life for Children With Controversial OSA Diagnoses Recruiting NCT03370731 Not Applicable
14 Interactive Perioperative Teaching Platform (IPTP) Recruiting NCT03677453 Not Applicable
15 Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population Active, not recruiting NCT03541434
16 Use of Sleep Endoscopy to Predict Outcomes of Pediatric Adenotonsillectomy Enrolling by invitation NCT02693977

Search NIH Clinical Center for Adenoid Hypertrophy

Genetic Tests for Adenoid Hypertrophy

Anatomical Context for Adenoid Hypertrophy

MalaCards organs/tissues related to Adenoid Hypertrophy:

41
Tonsil, Testes, Heart, Thyroid, Monocytes

Publications for Adenoid Hypertrophy

Articles related to Adenoid Hypertrophy:

(show top 50) (show all 128)
# Title Authors Year
1
Reply to the letter to the author concerning: 'Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?' ( 29423746 )
2018
2
Innate immunity gene expression by epithelial cells of upper respiratory tract in children with adenoid hypertrophy. ( 29500040 )
2018
3
Evaluation of choroidal thickness in children with adenoid hypertrophy. ( 29313145 )
2018
4
Superficial punctate keratopathy in a pediatric patient was related to adenoid hypertrophy and obstructive sleep apnea syndrome: a case report. ( 29471795 )
2018
5
Adenoid hypertrophy in children and allergic rhinitis. ( 28887688 )
2018
6
CYSLTR1 promotes adenoid hypertrophy by activating ERK1/2. ( 30116346 )
2018
7
The relationship between adenoid hypertrophy and gastroesophageal reflux disease: A meta-analysis. ( 30313042 )
2018
8
Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide. ( 30368395 )
2018
9
Halitosis in children with adenoid hypertrophy. ( 29146888 )
2017
10
Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: A randomized controlled trial. ( 28098165 )
2017
11
Significant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population. ( 28263490 )
2017
12
Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population. ( 28823693 )
2017
13
Prevalence of adenoid hypertrophy: A systematic review and meta-analysis. ( 29153763 )
2017
14
Myhre syndrome with novel findings: bilateral congenital cortical cataract, bilateral papilledema, accessory nipple, and adenoid hypertrophy. ( 28562390 )
2017
15
The pathogens profile in children with otitis media with effusion and adenoid hypertrophy. ( 28231295 )
2017
16
Correlation and reliability of cone-beam computed tomography nasopharyngeal volumetric and area measurements as determined by commercial software against nasopharyngoscopy-supported diagnosis of adenoid hypertrophy. ( 28651774 )
2017
17
Pre- and post-operative application of acoustic rhinometry in children with otitis media with effusion and with or without adenoid hypertrophy-a retrospective analysis. ( 29224765 )
2017
18
The common genetic variants of toll-like receptor and susceptibilityto adenoid hypertrophy: a hospital-based cohort study. ( 27966312 )
2016
19
Accuracy and reliability of orthodontists using cone-beam computerized tomography for assessment of adenoid hypertrophy. ( 27871704 )
2016
20
Accuracy and reliability of oral maxillofacial radiologists when evaluating cone-beam computed tomography imaging for adenoid hypertrophy screening: a comparison with nasopharyngoscopy. ( 27181449 )
2016
21
The relationship of enuresis nocturna and adenoid hypertrophy. ( 27377086 )
2016
22
The effect of adenoid hypertrophy and adenoidectomy in patients on cardiovascular risk reduction. ( 27405084 )
2016
23
Integrative versus Conventional Therapy of Chronic Otitis Media with Effusion and Adenoid Hypertrophy in Children: A Prospective Observational Study. ( 27607438 )
2016
24
Community level evaluation of adenoid hypertrophy on the basis of symptom scoring and its X-ray correlation. ( 28348992 )
2016
25
Does adenoid hypertrophy affect disease severity in children with allergic rhinitis? ( 27405740 )
2016
26
Tympanometric Findings among Children with Adenoid Hypertrophy in Port Harcourt, Nigeria. ( 27563311 )
2016
27
The effect of adenoid hypertrophy on maxillofacial development: an objective photographic analysis. ( 27647047 )
2016
28
Cognitive event related potentials in patients with adenoid hypertrophy; a case control pilot study. ( 26808619 )
2016
29
Adenoid hypertrophy and chronic rhinosinusitis: Helicobacter pylori on antral lavages, adenoid tissue and salival inmunoglobuline A on paediatric patients. ( 26746618 )
2016
30
MRI of nasopharyngeal adenoid hypertrophy. ( 27531860 )
2016
31
Effect of adenoid hypertrophy and pulmonary function tests in children with mild asthma. ( 27888821 )
2016
32
Prevalence of Panton-Valentine leucocidin and phenotypic and genotypic characterization of biofilm formation among Staphylococcus aureus strains isolated from children with adenoid hypertrophy. ( 26476288 )
2015
33
Health-related quality of life among children with adenoid hypertrophy in Xi'an, China. ( 26553400 )
2015
34
Nasal Mucociliary Clearance in Adenoid Hypertrophy and Otitis Media with Effusion. ( 26496764 )
2015
35
Adenoid hypertrophy in children with allergic disease and influential factors. ( 25758194 )
2015
36
Possible role of apoptosis in pathogenesis of adenoid hypertrophy and chronic adenoiditis: Prospective case-control study. ( 26003878 )
2015
37
A new clinical scoring system for adenoid hypertrophy in children. ( 25745612 )
2015
38
Systematic review and meta-analysis of randomized controlled trials on the role of mometasone in adenoid hypertrophy in children. ( 26235732 )
2015
39
Evaluation of middle ear pressure in the early period after adenoidectomy in children with adenoid hypertrophy without otitis media with effusion. ( 25766622 )
2015
40
Chicken or the egg: the dilemma of allergic rhinitis versus adenoid hypertrophy. ( 26030038 )
2015
41
ALLERGIC RHINITIS AND ADENOID HYPERTROPHY IN CHILDREN: IS ADENOIDECTOMY ALWAYS REALLY USEFUL? ( 26634589 )
2015
42
Montelukast in Adenoid Hypertrophy: Its Effect on Size and Symptoms. ( 26788489 )
2015
43
Response to "Mean platelet volume may not be beneficial for the management of patients with adenoid hypertrophy". ( 25887209 )
2015
44
[Expression of CysLTR-1 and CysLTR-2 in adenoid tissues from children with adenoid hypertrophy]. ( 25760841 )
2015
45
Does atopy influence the effectiveness of treatment of adenoid hypertrophy with mometasone furoate? ( 25590321 )
2015
46
Relative etiological importance of adenoid hypertrophy versus sinusitis in children with persistent rhinorrhoea. ( 25621229 )
2015
47
The effect of adenoidectomy operation made on patients with adenoid hypertrophy on cardiovascular risk reduction. ( 25974805 )
2015
48
Diffusion weighted imaging of nasopharyngeal adenoid hypertrophy. ( 24855289 )
2015
49
The effect of adenoid hypertrophy on tympanometric findings in children without hearing loss. ( 25547747 )
2014
50
Method of the diagnosis of adenoid hypertrophy for physicians: adenoid-nasopharynx ratio. ( 25153063 )
2014

Variations for Adenoid Hypertrophy

Expression for Adenoid Hypertrophy

Search GEO for disease gene expression data for Adenoid Hypertrophy.

Pathways for Adenoid Hypertrophy

Pathways related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.68 CYSLTR1 CYSLTR2
2
Show member pathways
10.3 CYSLTR1 CYSLTR2

GO Terms for Adenoid Hypertrophy

Cellular components related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.92 CD19 CYSLTR1 CYSLTR2 TRPV1

Biological processes related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.33 CD19 CYSLTR1 TRPV1
2 neuropeptide signaling pathway GO:0007218 9.32 CYSLTR1 CYSLTR2
3 response to heat GO:0009408 9.26 SOD1 TRPV1
4 cellular response to ATP GO:0071318 8.96 SOD1 TRPV1
5 leukotriene signaling pathway GO:0061737 8.62 CYSLTR1 CYSLTR2

Molecular functions related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled peptide receptor activity GO:0008528 9.16 CYSLTR1 CYSLTR2
2 galanin receptor activity GO:0004966 8.96 CYSLTR1 CYSLTR2
3 leukotriene receptor activity GO:0004974 8.62 CYSLTR1 CYSLTR2

Sources for Adenoid Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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