MCID: ADN067
MIFTS: 38

Adenoid Hypertrophy

Categories: Respiratory diseases

Aliases & Classifications for Adenoid Hypertrophy

MalaCards integrated aliases for Adenoid Hypertrophy:

Name: Adenoid Hypertrophy 12 15
Hypertrophy of Adenoids 73
Adenoidal Hypertrophy 12
Enlarged Adenoids 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060311
ICD10 33 J35.2
ICD9CM 35 474.12
SNOMED-CT 68 111591002 195795005
UMLS 73 C0149825

Summaries for Adenoid Hypertrophy

Disease Ontology : 12 An upper respiratory tract disease characterized by the unusual growth of the adenoid tonsil; has symptom snoring, has symptom hyponasality, has symptom otitis media with effusion, has symptom mouth breathing.

MalaCards based summary : Adenoid Hypertrophy, also known as hypertrophy of adenoids, is related to rhinitis and adenoiditis. An important gene associated with Adenoid Hypertrophy is CYSLTR2 (Cysteinyl Leukotriene Receptor 2), and among its related pathways/superpathways are Endothelins and Eicosanoid ligand-binding receptors. The drugs Sufentanil and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and thyroid, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Adenoid hypertrophy (or enlarged adenoids) is the unusual growth (hypertrophy) of the adenoid... more...

Related Diseases for Adenoid Hypertrophy

Graphical network of the top 20 diseases related to Adenoid Hypertrophy:



Diseases related to Adenoid Hypertrophy

Symptoms & Phenotypes for Adenoid Hypertrophy

MGI Mouse Phenotypes related to Adenoid Hypertrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 CD19 CYSLTR1 CYSLTR2 KIF7 SOD1 TRPV1
2 cellular MP:0005384 9.1 ARNT2 CD19 CYSLTR1 KIF7 SOD1 TRPV1

Drugs & Therapeutics for Adenoid Hypertrophy

Drugs for Adenoid Hypertrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
2
Ephedrine Approved Phase 4 299-42-3 9294
3
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
4
Phenylephrine Approved Phase 4 59-42-7 6041
5
Pseudoephedrine Approved Phase 4 90-82-4 7028
6
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
7
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
8
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
9
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
10
Propyl Gallate Investigational Phase 4 121-79-9 4947
11 Adjuvants, Anesthesia Phase 4
12 Analgesics Phase 4
13 Analgesics, Opioid Phase 4
14 Anesthetics Phase 4
15 Anesthetics, General Phase 4
16 Anesthetics, Intravenous Phase 4
17 Central Nervous System Depressants Phase 4
18 Narcotics Phase 4
19 Peripheral Nervous System Agents Phase 4
20 Adrenergic Agents Phase 4
21 Adrenergic Agonists Phase 4
22 Adrenergic alpha-Agonists Phase 4
23 Anti-Allergic Agents Phase 4,Phase 3
24 Anti-Inflammatory Agents Phase 4,Phase 3
25 Autonomic Agents Phase 4
26 Dermatologic Agents Phase 4,Phase 3
27 mometasone furoate Phase 4,Phase 3
28 Mydriatics Phase 4
29 Nasal Decongestants Phase 4
30 Neurotransmitter Agents Phase 4
31 Protective Agents Phase 4
32 Respiratory System Agents Phase 4
33 Vasoconstrictor Agents Phase 4
34 Antacids Phase 4
35 Anti-Ulcer Agents Phase 4
36 Gastrointestinal Agents Phase 4
37 Proton Pump Inhibitors Phase 4
38 Broncho-Vaxom Phase 4

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
2 Mometasone Furoate and Oxymetazoline in the Treatment of Adenoid Hypertrophy Completed NCT02559440 Phase 4 mometasone furoate;Placebo;Oxymetazoline + Placebo;Placebo + placebo;mometasone furoate + Placebo;mometasone furoate + Oxymetazoline
3 Nasonex (Mometasone Furoate Nasal Spray) in Adenoids Hypertrophy in Children (P04367) Completed NCT01098071 Phase 4 mometasone furoate nasal spray
4 Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children Completed NCT01082029 Phase 4 Lansoprazole;Placebo
5 Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy Not yet recruiting NCT03243565 Phase 4
6 Placebo-controlled Trial With Nasonex for Nasal Obstruction Secondary to Adenoids Hypertrophy in Children (P04367)(TERMINATED) Terminated NCT00553891 Phase 4 mometasone furoate nasal spray;placebo nasal spray
7 Efficacy and Safety of Mometasone Furoate Nasal Spray in Children With Adenoid Hypertrophy. SNORE Study (P05155) Completed NCT00552032 Phase 3 Mometasone Furoate nasal spray;Placebo
8 Adenoidectomy, Myringotomy and Tubes' Insertion vs Adenoidectomy and Myringotomy Alone in Children With Otitis Media With Effusion and Adenoid Hypertrophy Completed NCT00629694 Phase 2
9 The Influence of Feeding Position on Pulmonary Morbidity in Young Children Unknown status NCT00248391 Not Applicable
10 Assessment of Adenoidal Obstruction in Children : Clinical Signs Versus Flexible Nasal Endoscopy and Roentgenographic Findings Completed NCT01965457
11 Surgical Versus Nonsurgical Treatment on Quality of Life for Children With Controversial OSA Diagnoses Recruiting NCT03370731 Not Applicable
12 Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population Active, not recruiting NCT03541434
13 Use of Sleep Endoscopy to Predict Outcomes of Pediatric Adenotonsillectomy Enrolling by invitation NCT02693977
14 The Correlation Between Adenoid Hypertrophy and Body Temperature in Children Before and After Adenoidectomy Not yet recruiting NCT02965183 Not Applicable

Search NIH Clinical Center for Adenoid Hypertrophy

Genetic Tests for Adenoid Hypertrophy

Anatomical Context for Adenoid Hypertrophy

MalaCards organs/tissues related to Adenoid Hypertrophy:

41
Tonsil, Testes, Thyroid, Heart

Publications for Adenoid Hypertrophy

Articles related to Adenoid Hypertrophy:

(show top 50) (show all 62)
# Title Authors Year
1
Reply to the letter to the author concerning: 'Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?' ( 29423746 )
2018
2
Innate immunity gene expression by epithelial cells of upper respiratory tract in children with adenoid hypertrophy. ( 29500040 )
2018
3
Evaluation of choroidal thickness in children with adenoid hypertrophy. ( 29313145 )
2018
4
Superficial punctate keratopathy in a pediatric patient was related to adenoid hypertrophy and obstructive sleep apnea syndrome: a case report. ( 29471795 )
2018
5
Halitosis in children with adenoid hypertrophy. ( 29146888 )
2017
6
Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: A randomized controlled trial. ( 28098165 )
2017
7
Significant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population. ( 28263490 )
2017
8
Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population. ( 28823693 )
2017
9
Prevalence of adenoid hypertrophy: A systematic review and meta-analysis. ( 29153763 )
2017
10
Myhre syndrome with novel findings: bilateral congenital cortical cataract, bilateral papilledema, accessory nipple, and adenoid hypertrophy. ( 28562390 )
2017
11
The pathogens profile in children with otitis media with effusion and adenoid hypertrophy. ( 28231295 )
2017
12
Correlation and reliability of cone-beam computed tomography nasopharyngeal volumetric and area measurements as determined by commercial software against nasopharyngoscopy-supported diagnosis of adenoid hypertrophy. ( 28651774 )
2017
13
Pre- and post-operative application of acoustic rhinometry in children with otitis media with effusion and with or without adenoid hypertrophy-a retrospective analysis. ( 29224765 )
2017
14
Adenoid hypertrophy in children and allergic rhinitis. ( 28887688 )
2017
15
The common genetic variants of toll-like receptor and susceptibilityto adenoid hypertrophy: a hospital-based cohort study. ( 27966312 )
2016
16
Accuracy and reliability of orthodontists using cone-beam computerized tomography for assessment of adenoid hypertrophy. ( 27871704 )
2016
17
Accuracy and reliability of oral maxillofacial radiologists when evaluating cone-beam computed tomography imaging for adenoid hypertrophy screening: a comparison with nasopharyngoscopy. ( 27181449 )
2016
18
The relationship of enuresis nocturna and adenoid hypertrophy. ( 27377086 )
2016
19
The effect of adenoid hypertrophy and adenoidectomy in patients on cardiovascular risk reduction. ( 27405084 )
2016
20
Integrative versus Conventional Therapy of Chronic Otitis Media with Effusion and Adenoid Hypertrophy in Children: A Prospective Observational Study. ( 27607438 )
2016
21
Community level evaluation of adenoid hypertrophy on the basis of symptom scoring and its X-ray correlation. ( 28348992 )
2016
22
Does adenoid hypertrophy affect disease severity in children with allergic rhinitis? ( 27405740 )
2016
23
Tympanometric Findings among Children with Adenoid Hypertrophy in Port Harcourt, Nigeria. ( 27563311 )
2016
24
The effect of adenoid hypertrophy on maxillofacial development: an objective photographic analysis. ( 27647047 )
2016
25
Cognitive event related potentials in patients with adenoid hypertrophy; a case control pilot study. ( 26808619 )
2016
26
Adenoid hypertrophy and chronic rhinosinusitis: Helicobacter pylori on antral lavages, adenoid tissue and salival inmunoglobuline A on paediatric patients. ( 26746618 )
2016
27
MRI of nasopharyngeal adenoid hypertrophy. ( 27531860 )
2016
28
Effect of adenoid hypertrophy and pulmonary function tests in children with mild asthma. ( 27888821 )
2016
29
Prevalence of Panton-Valentine leucocidin and phenotypic and genotypic characterization of biofilm formation among Staphylococcus aureus strains isolated from children with adenoid hypertrophy. ( 26476288 )
2015
30
Health-related quality of life among children with adenoid hypertrophy in Xi'an, China. ( 26553400 )
2015
31
Nasal Mucociliary Clearance in Adenoid Hypertrophy and Otitis Media with Effusion. ( 26496764 )
2015
32
Adenoid hypertrophy in children with allergic disease and influential factors. ( 25758194 )
2015
33
Possible role of apoptosis in pathogenesis of adenoid hypertrophy and chronic adenoiditis: Prospective case-control study. ( 26003878 )
2015
34
A new clinical scoring system for adenoid hypertrophy in children. ( 25745612 )
2015
35
Systematic review and meta-analysis of randomized controlled trials on the role of mometasone in adenoid hypertrophy in children. ( 26235732 )
2015
36
Evaluation of middle ear pressure in the early period after adenoidectomy in children with adenoid hypertrophy without otitis media with effusion. ( 25766622 )
2015
37
Chicken or the egg: the dilemma of allergic rhinitis versus adenoid hypertrophy. ( 26030038 )
2015
38
ALLERGIC RHINITIS AND ADENOID HYPERTROPHY IN CHILDREN: IS ADENOIDECTOMY ALWAYS REALLY USEFUL? ( 26634589 )
2015
39
Montelukast in Adenoid Hypertrophy: Its Effect on Size and Symptoms. ( 26788489 )
2015
40
[Expression of CysLTR-1 and CysLTR-2 in adenoid tissues from children with adenoid hypertrophy]. ( 25760841 )
2015
41
Does atopy influence the effectiveness of treatment of adenoid hypertrophy with mometasone furoate? ( 25590321 )
2015
42
Relative etiological importance of adenoid hypertrophy versus sinusitis in children with persistent rhinorrhoea. ( 25621229 )
2015
43
The effect of adenoidectomy operation made on patients with adenoid hypertrophy on cardiovascular risk reduction. ( 25974805 )
2015
44
The effect of adenoid hypertrophy on tympanometric findings in children without hearing loss. ( 25547747 )
2014
45
Method of the diagnosis of adenoid hypertrophy for physicians: adenoid-nasopharynx ratio. ( 25153063 )
2014
46
Ectopic thyroid papillary carcinoma of nasopharynx associated with adenoid hypertrophy: an unusual presentation. ( 25238975 )
2014
47
Chlamydophila pneumoniae Infection Assessment in Children With Adenoid Hypertrophy Concomitant With Rhino Sinusitis. ( 25485049 )
2014
48
Articulation error of children with adenoid hypertrophy. ( 25114693 )
2014
49
Validity of acoustic rhinometry in the evaluation of patients with adenoid hypertrophy. ( 25006902 )
2014
50
Agreement between cone-beam computed tomography and nasoendoscopy evaluations of adenoid hypertrophy. ( 25263148 )
2014

Variations for Adenoid Hypertrophy

Expression for Adenoid Hypertrophy

Search GEO for disease gene expression data for Adenoid Hypertrophy.

Pathways for Adenoid Hypertrophy

Pathways related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.68 CYSLTR1 CYSLTR2
2
Show member pathways
10.3 CYSLTR1 CYSLTR2

GO Terms for Adenoid Hypertrophy

Biological processes related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.4 CYSLTR1 CYSLTR2
2 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 9.37 CYSLTR1 CYSLTR2
3 cell surface receptor signaling pathway GO:0007166 9.33 CD19 CYSLTR1 TRPV1
4 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 9.32 CYSLTR1 CYSLTR2
5 response to heat GO:0009408 9.26 SOD1 TRPV1
6 cellular response to ATP GO:0071318 8.96 SOD1 TRPV1
7 leukotriene signaling pathway GO:0061737 8.62 CYSLTR1 CYSLTR2

Molecular functions related to Adenoid Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled peptide receptor activity GO:0008528 9.26 CYSLTR1 CYSLTR2
2 galanin receptor activity GO:0004966 9.16 CYSLTR1 CYSLTR2
3 cysteinyl leukotriene receptor activity GO:0001631 8.96 CYSLTR1 CYSLTR2
4 leukotriene receptor activity GO:0004974 8.62 CYSLTR1 CYSLTR2

Sources for Adenoid Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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