MCID: ADN013
MIFTS: 41

Adenoid Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Adenoid Squamous Cell Carcinoma

MalaCards integrated aliases for Adenoid Squamous Cell Carcinoma:

Name: Adenoid Squamous Cell Carcinoma 12 15
Adenocarcinoma with Squamous Metaplasia 12 74
Acantholytic Squamous Cell Carcinoma 12 74
Pseudoglandular Squamous Carcinoma 12
Adenoacanthoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5524
NCIt 51 C4106 C4200
SNOMED-CT 69 15176003 85956000

Summaries for Adenoid Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis.

MalaCards based summary : Adenoid Squamous Cell Carcinoma, also known as adenocarcinoma with squamous metaplasia, is related to angiosarcoma and eyelid carcinoma. An important gene associated with Adenoid Squamous Cell Carcinoma is CDH1 (Cadherin 1), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. The drugs Capecitabine and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Adenoid Squamous Cell Carcinoma

Diseases related to Adenoid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 30.1 KRT8 PECAM1 VIM
2 eyelid carcinoma 30.0 KRT20 KRT7
3 cystadenofibroma 29.9 KRT20 KRT7
4 adenosquamous carcinoma 29.7 KRT7 KRT8
5 mesothelioma, malignant 29.7 KRT20 KRT7 VIM
6 papillary adenocarcinoma 29.7 CDH1 KRT7 VIM
7 mammary paget's disease 29.6 KRT20 KRT7 KRT8
8 acantholytic squamous cell skin carcinoma 11.9
9 endometrial adenocarcinoma 11.6
10 ovary adenocarcinoma 11.1
11 squamous cell carcinoma 10.7
12 biphasic synovial sarcoma 10.2 CDH1 VIM
13 breast ductal carcinoma 10.2 CDH1 KRT8
14 endometrial adenosquamous carcinoma 10.2
15 goblet cell carcinoid 10.2 CDH1 KRT20
16 chondroid chordoma 10.2 CDH1 VIM
17 morpheaform basal cell carcinoma 10.2 CDH1 KRT20
18 keratosis 10.2
19 in situ carcinoma 10.2
20 pleomorphic liposarcoma 10.2 KRT8 VIM
21 odontoma 10.2 KRT8 VIM
22 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 10.2 KRT8 VIM
23 tubular adenocarcinoma 10.1 CDH1 KRT20
24 dendritic cell tumor 10.1 KRT20 VIM
25 villous adenoma 10.1 KRT20 KRT8
26 gastrointestinal system cancer 10.1 CDH1 KRT7
27 benign mesothelioma 10.1
28 pleomorphic adenoma carcinoma 10.1
29 adenocarcinoma 10.1
30 skin squamous cell carcinoma 10.1
31 pleomorphic adenoma 10.1
32 gallbladder squamous cell carcinoma 10.1
33 esophageal adenosquamous carcinoma 10.1
34 adenoma 10.1
35 actinic keratosis 10.1
36 renal pelvis adenocarcinoma 10.0 CDH1 KRT7
37 parachordoma 10.0 KRT7 VIM
38 secretory meningioma 10.0 KRT7 VIM
39 cervical squamous cell carcinoma 10.0 CDH1 KRT8
40 breast adenomyoepithelioma 10.0 CDH1 KRT7
41 nodular hidradenoma 10.0 KRT7 VIM
42 hidradenoma 10.0 KRT7 VIM
43 breast myoepithelial neoplasm 10.0 CDH1 KRT7
44 papillary adenoma 10.0 KRT7 VIM
45 benign metastasizing leiomyoma 10.0 KRT7 VIM
46 squamous cell carcinoma, head and neck 10.0
47 penile cancer, adult 10.0
48 monophasic synovial sarcoma 10.0 KRT7 VIM
49 cervical adenocarcinoma 10.0 KRT20 KRT7
50 metanephric adenoma 10.0 KRT7 VIM

Graphical network of the top 20 diseases related to Adenoid Squamous Cell Carcinoma:



Diseases related to Adenoid Squamous Cell Carcinoma

Symptoms & Phenotypes for Adenoid Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

27 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.77 PECAM1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.77 VIM
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.77 PECAM1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.77 PECAM1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.77 PECAM1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.77 VIM
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.77 KRT7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.77 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.77 KRT7
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.77 PECAM1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.77 KRT7 PECAM1 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.23 KRT8
13 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.23 KRT7 KRT8
14 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.23 KRT7 KRT8
15 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.23 KRT8
16 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.23 KRT7 KRT8

Drugs & Therapeutics for Adenoid Squamous Cell Carcinoma

Drugs for Adenoid Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 3,Phase 2 154361-50-9 60953
2
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
3
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
4
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
5
Gemcitabine Approved Phase 3,Phase 2 95058-81-4 60750
6
Doxil Approved June 1999 Phase 3 31703
7 Antimetabolites, Antineoplastic Phase 3,Phase 2
8 Liver Extracts Phase 3,Phase 1
9 Antimetabolites Phase 3,Phase 2
10 Anti-Bacterial Agents Phase 3,Phase 2
11 Antibiotics, Antitubercular Phase 3
12 Topoisomerase Inhibitors Phase 3
13 Albumin-Bound Paclitaxel Phase 3
14 Immunosuppressive Agents Phase 3,Phase 2
15 Anti-Infective Agents Phase 3,Phase 2
16 Antiviral Agents Phase 3,Phase 2
17 Immunologic Factors Phase 3,Phase 2,Phase 1
18
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
19 Protein Kinase Inhibitors Phase 2
20
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
21 Angiogenesis Inhibitors Phase 2
22 Angiogenesis Modulating Agents Phase 2
23
Pancrelipase Approved, Investigational Phase 1 53608-75-6
24 Immunoglobulins Phase 1
25 Cola Phase 1
26 Antibodies, Monoclonal Phase 1
27 pancreatin Phase 1
28 Antibodies Phase 1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer Completed NCT00363584 Phase 3 capecitabine
2 Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Advanced Endometrial Cancer Completed NCT00002493 Phase 3 cisplatin;doxorubicin hydrochloride
3 Comparison of Radiation Therapy With or Without Combination Chemotherapy Following Surgery in Treating Patients With Stage I or Stage II Endometrial Cancer Completed NCT00006027 Phase 3 cisplatin;paclitaxel
4 Gemcitabine With or Without Capecitabine in Treating Patients With Locally Advanced, Unresectable, or Metastatic Biliary Cancer Terminated NCT00658593 Phase 3 capecitabine;gemcitabine hydrochloride
5 Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT01093222 Phase 2 Erlotinib Hydrochloride;Sorafenib Tosylate
6 S0514 Sorafenib in Treating Patients With Unresectable or Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00238212 Phase 2 sorafenib tosylate
7 Thalidomide in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT00025467 Phase 2 thalidomide
8 S0202 Gemcitabine and Capecitabine for Unresectable Locally Advanced Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00033540 Phase 2 capecitabine;gemcitabine hydrochloride
9 Intensity-Modulated Radiation Therapy to the Pelvis With or Without Chemotherapy in Treating Patients With Endometrial Cancer or Cervical Cancer That Has Been Removed By Surgery Completed NCT00331760 Phase 2 cisplatin
10 Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced Gallbladder or Bile Duct Cancer That Cannot Be Removed By Surgery Withdrawn NCT01859182 Phase 2 selumetinib;Akt inhibitor MK2206
11 RAV12 in Treating Patients With Metastatic or Recurrent Adenocarcinoma Completed NCT00101972 Phase 1
12 Gene Therapy in Treating Patients With Cancer Completed NCT00004178 Phase 1

Search NIH Clinical Center for Adenoid Squamous Cell Carcinoma

Genetic Tests for Adenoid Squamous Cell Carcinoma

Anatomical Context for Adenoid Squamous Cell Carcinoma

MalaCards organs/tissues related to Adenoid Squamous Cell Carcinoma:

42
Breast, Skin, Lung, Liver, Ovary, Appendix, Thymus

Publications for Adenoid Squamous Cell Carcinoma

Articles related to Adenoid Squamous Cell Carcinoma:

(show all 46)
# Title Authors Year
1
Characteristic imaging findings of acantholytic squamous cell carcinoma: a case report. ( 30798506 )
2019
2
Adenoid Squamous Cell Carcinoma of Oral Cavity: a Case Report. ( 29492419 )
2018
3
Acantholytic Squamous Cell Carcinoma and Salivary Duct Carcinoma Ex-pleomorphic Adenoma of the Submandibular Gland: A Report of Two Extremely Rare Cases with an Immunohistochemical Analysis. ( 30484070 )
2018
4
Morphologic mimicry: acantholytic squamous cell carcinoma in nondermal locations-a literature review. ( 29744885 )
2018
5
Acantholytic squamous cell carcinoma of the gallbladder mimicking adenocarcinoma. ( 29671927 )
2018
6
Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report. ( 29548309 )
2018
7
Acantholytic squamous cell carcinoma is usually associated with hair follicles, not acantholytic actinic keratosis, and is not "high risk": Diagnosis, management, and clinical outcomes in a series of 115 cases. ( 27889291 )
2017
8
Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma. ( 29085501 )
2017
9
Pulmonary acantholytic squamous cell carcinoma with focal signet ring cell morphology mimicking malignant mesothelioma on fine needle aspiration cytology: a case report. ( 25828595 )
2016
10
Expression of desmosomal proteins in acantholytic squamous cell carcinoma of the skin. ( 25723181 )
2015
11
Adenoid squamous cell carcinoma of the oral cavity. ( 22808297 )
2012
12
Pseudovascular adenoid squamous cell carcinoma of oral cavity: A mimicker of angiosarcoma. ( 22923907 )
2012
13
Collision of atypical fibroxanthoma and acantholytic squamous cell carcinoma in situ. ( 22728719 )
2012
14
Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report. ( 19615013 )
2010
15
Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma. ( 18671846 )
2008
16
Primary adenoid squamous cell carcinoma of the oral cavity. ( 16445819 )
2006
17
Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma. ( 16856971 )
2006
18
Pseudovascular adenoid squamous-cell carcinoma of the oral cavity--a report of two cases. ( 17071808 )
2006
19
Immunohistochemical and cytogenetic characterization of acantholytic squamous cell carcinoma of the breast. ( 15668805 )
2005
20
The expression of syndecan-1 is preferentially reduced compared with that of E-cadherin in acantholytic squamous cell carcinoma. ( 11168756 )
2001
21
A case of adenoid squamous cell carcinoma of the breast skin. ( 11341233 )
2000
22
Primary adenoid squamous cell carcinoma of the upper lip associated with a locoregional metastasis: a case report and review of the literature. ( 10319839 )
1999
23
Fine-needle aspiration cytologic features of pseudovascular adenoid squamous-cell carcinoma of the lung. ( 10495320 )
1999
24
A Case of Adenoid Squamous Cell Carcinoma of the Breast Skin. ( 11091718 )
1999
25
Acantholytic squamous cell carcinoma of skin--a case report. ( 10028800 )
1998
26
A case of pseudovascular adenoid squamous cell carcinoma of the skin with spindle cell pattern. ( 9350106 )
1997
27
Mucosal adenoid squamous cell carcinoma of the head and neck. ( 8651637 )
1996
28
Pseudovascular adenoid squamous cell carcinoma of the lung: clinicopathologic study of three cases and comparison with true pleuropulmonary angiosarcoma. ( 8163270 )
1994
29
Oral adenoid squamous cell carcinoma: a report of three cases and review of the literature. ( 8492207 )
1993
30
Pseudovascular adenoid squamous cell carcinoma of the skin. A neoplasm that may be mistaken for angiosarcoma. ( 1599022 )
1992
31
Adenoid Squamous Cell Carcinoma. ( 28134144 )
1988
32
Adenoid squamous cell carcinoma of the nasopharynx and neck region. ( 3518653 )
1986
33
Adenoid squamous cell carcinoma of the skin overlying the right breast. An autopsy case clinically manifested with rapid growth and widely spreading metastases. ( 3825538 )
1986
34
A case of acantholytic squamous cell carcinoma derived from the acantholytic type of solar keratosis. ( 3546442 )
1986
35
A clinicopathologic study of 21 cases of adenoid squamous cell carcinoma of the eyelid and periorbital region. ( 3976805 )
1985
36
Adenoid squamous cell carcinoma of the penis. Report of a surgical case clinically manifested with rapid lung metastasis. ( 6670557 )
1983
37
Adenosquamous carcinoma of skin appendages (adenoid squamous cell carcinoma, pseudoglandular squamous cell carcinoma, adenocanthoma of sweat gland of Lever) of the vulva: a clinical and ultrastructural study. ( 709534 )
1978
38
Adenoid squamous cell carcinoma of the oral cavity: report of the first case arising in the tongue. ( 880122 )
1977
39
Adenoid squamous cell carcinoma of the oral mucosa: report of two autopsy cases. ( 922664 )
1977
40
Adenoid squamous-cell carcinoma of vermilion mucosa of lower lip. ( 4521951 )
1974
41
Adenoid squamous cell carcinoma of the vulva. ( 4810097 )
1974
42
Adenoid squamous cell carcinoma of the lip: report of cases. ( 4504554 )
1972
43
Multiple adenoid squamous cell carcinoma. ( 5093173 )
1971
44
Adenoid squamous-cell carcinoma (adenocanthoma) of the oral labial mucosa. A clinicopathologic study of fifteen cases. ( 5285191 )
1971
45
Adenoid squamous cell carcinoma (adenoacanthoma). A clinicopathologic study of 155 patients. ( 5927198 )
1966
46
ADENOID SQUAMOUS CELL CARCINOMA (ADENOACANTHOMA OF LEVER). REPORT OF SEVEN CASES AND REVIEW. ( 14107628 )
1964

Variations for Adenoid Squamous Cell Carcinoma

Expression for Adenoid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Adenoid Squamous Cell Carcinoma.

Pathways for Adenoid Squamous Cell Carcinoma

Pathways related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.89 KRT20 KRT7 KRT8
2 11.51 CDH1 KRT20 KRT7 KRT8 VIM
3 11.19 KRT8 VIM
4
Show member pathways
11.17 KRT7 KRT8 VIM
5 10.41 CDH1 VIM

GO Terms for Adenoid Squamous Cell Carcinoma

Cellular components related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 CDH1 KRT7 KRT8 PECAM1 VIM
2 cell periphery GO:0071944 9.16 KRT8 PECAM1
3 intermediate filament GO:0005882 8.92 KRT20 KRT7 KRT8 VIM

Biological processes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.43 KRT7 KRT8 VIM
2 keratinization GO:0031424 9.33 KRT20 KRT7 KRT8
3 intermediate filament organization GO:0045109 8.96 KRT20 VIM
4 cornification GO:0070268 8.8 KRT20 KRT7 KRT8

Molecular functions related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.96 KRT8 VIM
2 structural molecule activity GO:0005198 8.32 VIM

Sources for Adenoid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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