MCID: ADN013
MIFTS: 39

Adenoid Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Adenoid Squamous Cell Carcinoma

MalaCards integrated aliases for Adenoid Squamous Cell Carcinoma:

Name: Adenoid Squamous Cell Carcinoma 12 15
Adenocarcinoma with Squamous Metaplasia 12 73
Acantholytic Squamous Cell Carcinoma 12 73
Pseudoglandular Squamous Carcinoma 12
Adenoacanthoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5524
NCIt 50 C4106 C4200
SNOMED-CT 68 15176003 85956000

Summaries for Adenoid Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis.

MalaCards based summary : Adenoid Squamous Cell Carcinoma, also known as adenocarcinoma with squamous metaplasia, is related to angiosarcoma and cystadenofibroma. An important gene associated with Adenoid Squamous Cell Carcinoma is CDH1 (Cadherin 1), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. Affiliated tissues include skin, liver and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Adenoid Squamous Cell Carcinoma

Diseases related to Adenoid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 30.5 KRT8 VIM
2 cystadenofibroma 29.9 KRT20 KRT7
3 papillary adenocarcinoma 29.7 CDH1 KRT7 VIM
4 adenosquamous carcinoma 29.6 KRT7 KRT8
5 acantholytic squamous cell skin carcinoma 11.9
6 endometrial adenocarcinoma 11.6
7 ovary adenocarcinoma 11.1
8 squamous cell carcinoma 10.7
9 biphasic synovial sarcoma 10.2 CDH1 VIM
10 bladder disease 10.2 CDH1 KRT20
11 cervical squamous cell carcinoma 10.2 CDH1 KRT8
12 ductal carcinoma in situ 10.2 CDH1 KRT8
13 breast ductal carcinoma 10.2 CDH1 KRT8
14 goblet cell carcinoid 10.1 CDH1 KRT20
15 morpheaform basal cell carcinoma 10.1 CDH1 KRT20
16 chondroid chordoma 10.1 CDH1 VIM
17 pleomorphic liposarcoma 10.1 KRT8 VIM
18 odontoma 10.1 KRT8 VIM
19 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 10.1 KRT8 VIM
20 dendritic cell tumor 10.1 KRT20 VIM
21 tubular adenocarcinoma 10.1 CDH1 KRT20
22 villous adenoma 10.1 KRT20 KRT8
23 senile angioma 10.1 HBA1 VIM
24 gastrointestinal system cancer 10.0 CDH1 KRT7
25 lymphangioma 10.0 HBA1 VIM
26 liver angiosarcoma 10.0 HBA1 VIM
27 congenital epulis 10.0 HBA1 VIM
28 spastic paraplegia 3, autosomal dominant 10.0 CDH1 HBA1
29 keratosis 10.0
30 pleomorphic adenoma carcinoma 10.0
31 adenocarcinoma 10.0
32 skin squamous cell carcinoma 10.0
33 pleomorphic adenoma 10.0
34 gallbladder squamous cell carcinoma 10.0
35 esophageal adenosquamous carcinoma 10.0
36 adenoma 10.0
37 in situ carcinoma 10.0
38 actinic keratosis 10.0
39 hemangiopericytoma, malignant 10.0 HBA1 VIM
40 renal pelvis adenocarcinoma 10.0 CDH1 KRT7
41 carcinosarcoma 10.0 KRT7 VIM
42 parachordoma 10.0 KRT7 VIM
43 secretory meningioma 10.0 KRT7 VIM
44 nodular hidradenoma 10.0 KRT7 VIM
45 hidradenoma 10.0 KRT7 VIM
46 papillary adenoma 10.0 KRT7 VIM
47 breast adenomyoepithelioma 10.0 CDH1 KRT7
48 benign metastasizing leiomyoma 10.0 KRT7 VIM
49 breast myoepithelial neoplasm 10.0 CDH1 KRT7
50 monophasic synovial sarcoma 10.0 KRT7 VIM

Graphical network of the top 20 diseases related to Adenoid Squamous Cell Carcinoma:



Diseases related to Adenoid Squamous Cell Carcinoma

Symptoms & Phenotypes for Adenoid Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.23 KRT8
2 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.23 KRT7 KRT8
3 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.23 KRT7 KRT8
4 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.23 KRT8
5 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.23 KRT7 KRT8

Drugs & Therapeutics for Adenoid Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Adenoid Squamous Cell Carcinoma

Genetic Tests for Adenoid Squamous Cell Carcinoma

Anatomical Context for Adenoid Squamous Cell Carcinoma

MalaCards organs/tissues related to Adenoid Squamous Cell Carcinoma:

41
Skin, Liver, T Cells, Breast, Lung, Ovary, Thymus

Publications for Adenoid Squamous Cell Carcinoma

Articles related to Adenoid Squamous Cell Carcinoma:

(show all 41)
# Title Authors Year
1
Adenoid Squamous Cell Carcinoma of Oral Cavity: a Case Report. ( 29492419 )
2018
2
Acantholytic Squamous Cell Carcinoma and Salivary Duct Carcinoma Ex-pleomorphic Adenoma of the Submandibular Gland: A Report of Two Extremely Rare Cases with an Immunohistochemical Analysis. ( 30484070 )
2018
3
Acantholytic squamous cell carcinoma of the gallbladder mimicking adenocarcinoma. ( 29671927 )
2018
4
Acantholytic squamous cell carcinoma is usually associated with hair follicles, not acantholytic actinic keratosis, and is not "high risk": Diagnosis, management, and clinical outcomes in a series of 115 cases. ( 27889291 )
2017
5
Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma. ( 29085501 )
2017
6
Pulmonary acantholytic squamous cell carcinoma with focal signet ring cell morphology mimicking malignant mesothelioma on fine needle aspiration cytology: a case report. ( 25828595 )
2015
7
Expression of desmosomal proteins in acantholytic squamous cell carcinoma of the skin. ( 25723181 )
2015
8
Adenoid squamous cell carcinoma of the oral cavity. ( 22808297 )
2012
9
Pseudovascular adenoid squamous cell carcinoma of oral cavity: A mimicker of angiosarcoma. ( 22923907 )
2012
10
Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report. ( 19615013 )
2010
11
Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma. ( 18671846 )
2008
12
Primary adenoid squamous cell carcinoma of the oral cavity. ( 16445819 )
2006
13
Pseudovascular adenoid squamous-cell carcinoma of the oral cavity--a report of two cases. ( 17071808 )
2006
14
Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma. ( 16856971 )
2006
15
Immunohistochemical and cytogenetic characterization of acantholytic squamous cell carcinoma of the breast. ( 15668805 )
2005
16
The expression of syndecan-1 is preferentially reduced compared with that of E-cadherin in acantholytic squamous cell carcinoma. ( 11168756 )
2001
17
A case of adenoid squamous cell carcinoma of the breast skin. ( 11341233 )
2000
18
Primary adenoid squamous cell carcinoma of the upper lip associated with a locoregional metastasis: a case report and review of the literature. ( 10319839 )
1999
19
Fine-needle aspiration cytologic features of pseudovascular adenoid squamous-cell carcinoma of the lung. ( 10495320 )
1999
20
A Case of Adenoid Squamous Cell Carcinoma of the Breast Skin. ( 11091718 )
1999
21
Acantholytic squamous cell carcinoma of skin--a case report. ( 10028800 )
1998
22
A case of pseudovascular adenoid squamous cell carcinoma of the skin with spindle cell pattern. ( 9350106 )
1997
23
Mucosal adenoid squamous cell carcinoma of the head and neck. ( 8651637 )
1996
24
Pseudovascular adenoid squamous cell carcinoma of the lung: clinicopathologic study of three cases and comparison with true pleuropulmonary angiosarcoma. ( 8163270 )
1994
25
Oral adenoid squamous cell carcinoma: a report of three cases and review of the literature. ( 8492207 )
1993
26
Pseudovascular adenoid squamous cell carcinoma of the skin. A neoplasm that may be mistaken for angiosarcoma. ( 1599022 )
1992
27
Adenoid Squamous Cell Carcinoma. ( 28134144 )
1988
28
Adenoid squamous cell carcinoma of the skin overlying the right breast. An autopsy case clinically manifested with rapid growth and widely spreading metastases. ( 3825538 )
1986
29
Adenoid squamous cell carcinoma of the nasopharynx and neck region. ( 3518653 )
1986
30
A clinicopathologic study of 21 cases of adenoid squamous cell carcinoma of the eyelid and periorbital region. ( 3976805 )
1985
31
Adenoid squamous cell carcinoma of the penis. Report of a surgical case clinically manifested with rapid lung metastasis. ( 6670557 )
1983
32
Adenosquamous carcinoma of skin appendages (adenoid squamous cell carcinoma, pseudoglandular squamous cell carcinoma, adenocanthoma of sweat gland of Lever) of the vulva: a clinical and ultrastructural study. ( 709534 )
1978
33
Adenoid squamous cell carcinoma of the oral cavity: report of the first case arising in the tongue. ( 880122 )
1977
34
Adenoid squamous cell carcinoma of the oral mucosa: report of two autopsy cases. ( 922664 )
1977
35
Adenoid squamous-cell carcinoma of vermilion mucosa of lower lip. ( 4521951 )
1974
36
Adenoid squamous cell carcinoma of the vulva. ( 4810097 )
1974
37
Adenoid squamous cell carcinoma of the lip: report of cases. ( 4504554 )
1972
38
Multiple adenoid squamous cell carcinoma. ( 5093173 )
1971
39
Adenoid squamous-cell carcinoma (adenocanthoma) of the oral labial mucosa. A clinicopathologic study of fifteen cases. ( 5285191 )
1971
40
Adenoid squamous cell carcinoma (adenoacanthoma). A clinicopathologic study of 155 patients. ( 5927198 )
1966
41
ADENOID SQUAMOUS CELL CARCINOMA (ADENOACANTHOMA OF LEVER). REPORT OF SEVEN CASES AND REVIEW. ( 14107628 )
1964

Variations for Adenoid Squamous Cell Carcinoma

Expression for Adenoid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Adenoid Squamous Cell Carcinoma.

Pathways for Adenoid Squamous Cell Carcinoma

Pathways related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.89 KRT20 KRT7 KRT8
2 11.51 CDH1 KRT20 KRT7 KRT8 VIM
3 11.19 KRT8 VIM
4
Show member pathways
11.17 KRT7 KRT8 VIM
5 10.41 CDH1 VIM

GO Terms for Adenoid Squamous Cell Carcinoma

Cellular components related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 CDH1 HBA1 KRT7 KRT8 VIM
2 intermediate filament GO:0005882 8.92 KRT20 KRT7 KRT8 VIM

Biological processes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.43 KRT7 KRT8 VIM
2 keratinization GO:0031424 9.33 KRT20 KRT7 KRT8
3 intermediate filament organization GO:0045109 8.96 KRT20 VIM
4 cornification GO:0070268 8.8 KRT20 KRT7 KRT8

Molecular functions related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.96 KRT8 VIM
2 structural molecule activity GO:0005198 8.8 KRT7 KRT8 VIM

Sources for Adenoid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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