Adenoid Squamous Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Adenoid Squamous Cell Carcinoma

MalaCards integrated aliases for Adenoid Squamous Cell Carcinoma:

Name: Adenoid Squamous Cell Carcinoma ¹¹ ¹⁴

Adenocarcinoma with Squamous Metaplasia ¹¹ ⁷¹

Acantholytic Squamous Cell Carcinoma ¹¹ ⁷¹

Pseudoglandular Squamous Carcinoma ¹¹

Adenoacanthoma ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:5524

NCIt ⁴⁹ C4200

SNOMED-CT ⁶⁸ 15176003 85956000

UMLS ⁷¹ C0334250 C0334393

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Summaries for Adenoid Squamous Cell Carcinoma

Disease Ontology: ¹¹ A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis.

MalaCards based summary: Adenoid Squamous Cell Carcinoma, also known as adenocarcinoma with squamous metaplasia, is related to ovary adenocarcinoma and angiosarcoma. An important gene associated with Adenoid Squamous Cell Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and Cytoskeletal Signaling. The drugs Erlotinib and Sorafenib have been mentioned in the context of this disorder. Affiliated tissues include ovary, lymph node and cervix, and related phenotypes are Increased shRNA abundance (Z-score > 2) and digestive/alimentary

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Related Diseases for Adenoid Squamous Cell Carcinoma

Diseases related to Adenoid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 531)

#	Related Disease	Score	Top Affiliating Genes
1	ovary adenocarcinoma	30.9	TP53 KRT7 CEACAM5 CDH1
2	angiosarcoma	30.9	PECAM1 KRT8 CD34
3	skin squamous cell carcinoma	30.5	TP53 KRT5 CDH1
4	basosquamous carcinoma	30.3	TP53 KRT7
5	lip and oral cavity cancer	30.1	TP53 KRT19 CDH1
6	mucoepidermoid carcinoma	30.1	KRT8 KRT7 KRT19 CDH1
7	acanthoma	30.1	TP53 KRT5
8	adenosquamous carcinoma	30.0	KRT8 KRT7 KRT5 KRT19 CEACAM5
9	squamous cell carcinoma	30.0	TP53 KRT7 KRT19 CEACAM5 CDH1
10	cystadenofibroma	30.0	TP53 KRT7
11	basaloid squamous cell carcinoma	29.9	TP53 KRT8 KRT7 KRT5
12	adenoma	29.9	TP53 KRT7 KRT19 CDH1
13	adenoid cystic carcinoma	29.8	TP53 KRT7 KRT19 CDH1
14	mucinous ovarian cystadenoma	29.8	KRT7 CEACAM5
15	mesothelioma, malignant	29.8	KRT7 KRT5 CEACAM5 CDH1
16	paget disease, extramammary	29.8	KRT7 KRT5 KRT19 CEACAM5
17	benign mesothelioma	29.8	KRT7 KRT5 KRT19 CEACAM5
18	gallbladder adenocarcinoma	29.7	TP53 KRT7 CEACAM5
19	interstitial lung disease 2	29.7	TP53 PECAM1 CDH1 CD34
20	papilloma	29.7	TP53 KRT8 KRT7 KRT5 CDH1
21	small cell cancer of the lung	29.7	TP53 KRT7 CEACAM5
22	skin carcinoma	29.7	TP53 KRT8 KRT7 KRT5 CDH1
23	thyroid gland follicular carcinoma	29.5	TP53 KRT7 KRT19 CDH1
24	signet ring cell adenocarcinoma	29.5	TP53 KRT7 CEACAM5 CDH1
25	hemangioma	29.5	TP53 PECAM1 KRT7 CDH1 CD34
26	adenocarcinoma	29.5	TP53 KRT7 CEACAM5 CDH1
27	breast ductal carcinoma	29.5	TP53 KRT8 KRT7 KRT5 KRT19 CDH1
28	keratoacanthoma	29.5	TP53 KRT8 KRT19 DSG3 CDH1
29	esophageal adenosquamous carcinoma	29.3	TP53 KRT7 KRT5 CEACAM5 CDH1
30	papillary adenocarcinoma	29.2	TP53 KRT7 KRT5 CEACAM5
31	breast adenocarcinoma	28.8	TP53 PECAM1 KRT8 KRT7 KRT5 CEACAM5
32	pancreatic cancer	28.3	TP53 PECAM1 KRT8 KRT7 KRT19 CEACAM5
33	acantholytic squamous cell skin carcinoma	11.5
34	endometrial adenocarcinoma	11.2
35	squamous cell carcinoma, head and neck	10.5
36	endometrial cancer	10.4
37	vulva squamous cell carcinoma	10.4
38	breast adenomyoepithelioma	10.3	KRT7 KRT5
39	lymphoepithelioma-like thymic carcinoma	10.3	KRT8 KRT5
40	laryngeal adenoid cystic carcinoma	10.3	KRT7 KRT5
41	inverted transitional papilloma	10.3	KRT7 KRT5
42	microinvasive cervical squamous cell carcinoma	10.3	KRT7 KRT5
43	ceruminoma	10.3	KRT7 KRT5
44	prostatic urethral cancer	10.3	KRT7 KRT5
45	rete testis neoplasm	10.3	KRT7 KRT5
46	rectum squamous cell carcinoma	10.3	KRT7 KRT5
47	middle ear adenoma	10.3	KRT7 KRT5
48	rete testis adenocarcinoma	10.3	KRT7 KRT5
49	auditory system benign neoplasm	10.3	KRT7 KRT5
50	breast mucoepidermoid carcinoma	10.3	KRT7 KRT5

Graphical network of the top 20 diseases related to Adenoid Squamous Cell Carcinoma:

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Symptoms & Phenotypes for Adenoid Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

²⁵ (show all 30)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	10.04	PECAM1
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	10.04	PECAM1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	10.04	PECAM1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	10.04	KRT8
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-13	10.04	KRT5 PECAM1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-135	10.04	KRT8 KRT7
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-14	10.04	EMP2 PECAM1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-140	10.04	PECAM1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-143	10.04	KRT5
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-147	10.04	EMP2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-17	10.04	KRT5
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	10.04	EMP2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-178	10.04	EMP2
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-180	10.04	EMP2 KRT5 KRT8 PECAM1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-192	10.04	KRT8 KRT7
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-200	10.04	KRT5
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-211	10.04	PECAM1
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	10.04	PECAM1
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-31	10.04	EMP2
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-40	10.04	KRT8
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.04	PECAM1
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-44	10.04	EMP2
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	10.04	EMP2
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	10.04	PECAM1
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-56	10.04	PECAM1
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-68	10.04	KRT7
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-72	10.04	KRT7
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	10.04	EMP2 KRT8 KRT7
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-75	10.04	PECAM1
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-91	10.04	KRT5 KRT7

MGI Mouse Phenotypes related to Adenoid Squamous Cell Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.91	CDH1 CEACAM5 DSC2 DSG3 KRT19 KRT5
2	cellular	MP:0005384	9.81	CD34 CDH1 CEACAM5 DSC2 DSG3 KRT19
3	cardiovascular system	MP:0005385	9.56	CDH1 CEACAM5 DSC2 EMP2 KRT19 KRT8
4	immune system	MP:0005387	9.36	CD34 CDH1 CEACAM5 DSC2 DSG3 EMP2

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Drugs & Therapeutics for Adenoid Squamous Cell Carcinoma

Drugs for Adenoid Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Erlotinib

Approved, Investigational

Phase 2

183319-69-9, 183321-74-6

176870

2

Sorafenib

Approved, Investigational

Phase 2

284461-73-0

216239

3

Thalidomide

Approved, Investigational, Withdrawn

Phase 2

50-35-1

5426

4

Protein Kinase Inhibitors

Phase 2

5

Anti-Bacterial Agents

Phase 2

6

Anti-Infective Agents

Phase 2

7

Angiogenesis Inhibitors

Phase 2

8

Immunosuppressive Agents

Phase 2

9

Immunologic Factors

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase II Study of Sorafenib (NSC-724772) and Erlotinib (NSC-718781) in Patients With Advanced Gallbladder Carcinoma or Cholangiocarcinoma	Completed	NCT01093222	Phase 2	Erlotinib Hydrochloride;Sorafenib Tosylate
2	Phase II Study of BAY 43-9006 (NSC #724772) as Single Agent in Unresectable or Metastatic Gallbladder Carcinoma and Cholangiocarcinoma	Completed	NCT00238212	Phase 2	sorafenib tosylate
3	A Phase II Evaluation of Thalidomide (NSC #66847, IND 48832) in the Treatment of Recurrent of Persistent Endometrial Carcinoma	Completed	NCT00025467	Phase 2	thalidomide
4	A Multicenter Phase II Study of the Combination of AZD6244 Hydrogen Sulfate and MK-2206 in Patients With Refractory Advanced Biliary Cancers	Withdrawn	NCT01859182	Phase 2	selumetinib;Akt inhibitor MK2206

Search NIH Clinical Center for Adenoid Squamous Cell Carcinoma

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Genetic Tests for Adenoid Squamous Cell Carcinoma

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Anatomical Context for Adenoid Squamous Cell Carcinoma

Organs/tissues related to Adenoid Squamous Cell Carcinoma:

MalaCards : Ovary, Lymph Node, Cervix, Uterus, Breast, Colon, Skin

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Publications for Adenoid Squamous Cell Carcinoma

Articles related to Adenoid Squamous Cell Carcinoma:

(show top 50) (show all 390)

#	Title	Authors	PMID	Year
1	Intra-oral Acantholytic Squamous Cell Carcinoma: 55 Cases. Is this Variant more Aggressive? ⁶²	Abba M...Allon I	34378166	2022
2	Acantholytic Squamous Cell Carcinoma Arising From Lichen Sclerosus: A Rare Case Affecting Vulvar Skin. ⁶²	Barron CR...Smoller BR	34015795	2022
3	Acantholytic variant of squamous cell carcinoma in the mandible: A rare entity and a brief review. ⁶²	Shetty D...Kumar N	36321707	2022
4	Sonographic and pathological features of metaplastic squamous cell carcinoma of the breast: a case series. ⁶²	Ye XJ...Yan L	34688286	2021
5	Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Paget disease? A unifying concept and review of the literature. ⁶²	Sheldon JD...Chung CG	33893742	2021
6	Pseudovascular Adenoid Squamous Cell Carcinoma of Buccal Mucosa-a Rare Aggressive Variant. ⁶²	Vivek V...Shah RA	34295075	2021
7	Expression of Heat Shock Protein 105 in Cutaneous Squamous Cell Carcinoma: Correlation with Clinicopathological Characteristics. ⁶²	Jia M...Fang S	34163202	2021
8	Pulmonary Acantholytic Squamous Cell Carcinoma Mimicking Lepidic Pattern Adenocarcinoma. ⁶²	Yilmaz R...BedIr R	32282054	2021
9	Adenoid (Acantholytic) Squamous Cell Carcinoma of Mandibular Gingiva. ⁶²	Raut T...Shrestha A	34336306	2021
10	Adenoid squamous cell carcinoma of upper lip, a rare variant of squamous cell carcinoma: A case report. ⁶²	Bhogavaram B...Boggarapu BP	33532433	2020
11	A rare acantholytic variant of squamous cell carcinoma of the maxilla: A case report and literature review. ⁶²	Kim JE...Huh KH	32769927	2020
12	Acantholytic Squamous Cell Carcinoma and Salivary Duct Carcinoma Ex-pleomorphic Adenoma of the Submandibular Gland: A Report of Two Extremely Rare Cases with an Immunohistochemical Analysis. ⁶²	Kusafuka K...Sugino T	30484070	2020
13	Pseudovascular adenoid squamous cell carcinoma of the tongue: a case report and literature review. ⁶²	Han X...Shao X	32509083	2020
14	Oral variant of acantholytic squamous cell carcinoma-Histochemical and immunohistochemical features. ⁶²	Allon I...Vered M	31706621	2019
15	Characteristic imaging findings of acantholytic squamous cell carcinoma: a case report. ⁶²	Kang JH...Hwang EH	30798506	2019
16	Angiotropism in recurrent cutaneous squamous cell carcinoma: Implications for regional tumor recurrence and extravascular migratory spread. ⁶²	Fedda F...Nagarajan P	30414196	2019
17	Morphologic mimicry: acantholytic squamous cell carcinoma in nondermal locations-a literature review. ⁶²	Mohammad M...Wilcox R	29744885	2018
18	Shadow Cell Differentiation: A Comparative Analysis of Modes of Cell Death with Apoptosis and Epidermal/Trichilemmal Keratinization. ⁶²	Nakamura T	30197883	2018
19	Acantholytic squamous cell carcinoma of the gallbladder mimicking adenocarcinoma. ⁶²	Yorita K...Kitagawa Y	29671927	2018
20	Adenoid Squamous Cell Carcinoma of Oral Cavity: a Case Report. ⁶²	J C...Kendole RK	29492419	2018
21	Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report. ⁶²	Yorita K...Ito S	29548309	2018
22	Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma. ⁶²	Matsukuma S...Takeo H	29085501	2017
23	Metastasis of a Renal Collecting Duct Adenocarcinoma to the Oral Cavity After Tooth Extraction. ⁶²	Erkilic S...Gunhan O	28489662	2017
24	Acantholytic squamous cell carcinoma is usually associated with hair follicles, not acantholytic actinic keratosis, and is not "high risk": Diagnosis, management, and clinical outcomes in a series of 115 cases. ⁶²	Ogawa T...Fung MA	27889291	2017
25	[Esophageal adenocarcinoma: the clinicopathologic features, patterns of lymph node metastasis and its influencing factors]. ⁶²	Wang J...Guo Y	27531265	2016
26	Acantholytic squamous cell carcinoma of soft palate-case report and literature review. ⁶²	Lin JS...Liu CJ	30894973	2016
27	[Acantholytic squamous cell carcinoma of larynx as an uncommon variant of squamous cell carcinoma]. ⁶²	Tiken EE...Turkan S	27107606	2016
28	Acantholytic squamous cell carcinoma of the oesophagus with prevalent single isolated tumour cells including signet ring cells and many osteoclast-like giant cells. ⁶²	Lee D	27020507	2016
29	Acantholytic-Like Pattern in a Recurrent Melanoma Mimicking Acantholytic Squamous Cell Carcinoma: A Further Example Highlighting the Potential for Misdiagnosis. ⁶²	Cardoso JC...Tellechea O	26999345	2016
30	Pulmonary acantholytic squamous cell carcinoma with focal signet ring cell morphology mimicking malignant mesothelioma on fine needle aspiration cytology: a case report. ⁶²	Choi SE...Park HS	25828595	2016
31	Acantholytic squamous cell carcinoma of the lung showing significant signet ring cell component. ⁶²	Park HS...Lee S	26109084	2016
32	[Auricular Acantholytic Squamous Cell Carcinoma with Neck Metastasis and Lethal Outcome - Case Report]. ⁶²	Jotic A...Krstic B	26727870	2015
33	Expression of desmosomal proteins in acantholytic squamous cell carcinoma of the skin. ⁶²	Jurcic V...Zidar N	25723181	2015
34	Primary angiomatoid melanoma as an exceptional morphologic pattern in cutaneous melanoma. A case report and review of the literature. ⁶²	Ramos-Rodriguez G...Ortiz-Hidalgo C	25498159	2015
35	Pseudoepitheliomatous changes in a case of vegetating Darier–White disease: a unique histopathological finding. ⁶²	Pezzini C...Borroni G	25238450	2015
36	Shadow cell differentiation from squamoid morule in endometrial adenoacanthoma. ⁶²	Nakamura T	26722510	2015
37	Adenoid dysplasia of the oral mucosa. ⁶²	Bunn B...van Heerden WF	25442496	2014
38	Desmosomal defects in acantholytic squamous cell carcinomas. ⁶²	O'Shea C...Koch PJ	25264142	2014
39	Two different scenarios of squamous cell carcinoma within advanced Basal cell carcinomas: cases illustrating the importance of serial biopsy during vismodegib usage. ⁶²	Zhu GA...Chang AL	24740281	2014
40	Acantholytic squamous cell carcinoma of the oral cavity: A rare entity. ⁶²	Mardi K...Singh N	25364162	2014
41	Acantholytic squamous cell carcinoma: pathological study of nine cases with review of literature. ⁶²	Sajin M...Costache M	24969975	2014
42	Acantholytic squamous cell carcinoma arising in a nevus sebaceous: A case report. ⁶²	Alhumidi A	24533028	2013
43	Toxicology and Carcinogenesis Studies of Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine (3TC), and Nevirapine (NVP) (CAS Nos. 30516-87-1, 134678-17-4, 129618-40-2) in Genetically Modified C3B6.129F1-Trp53(tm1Brd) N12 Haploinsufficient Mice (in utero and postnatal gavage studies). ⁶²	National Toxicology Program	24503698	2013
44	Acantholytic squamous cell carcinoma of the maxilla: unusual location and aggressive behavior of a rare histologic variant. ⁶²	Ozgursoy OB...Kucuk B	24057911	2013
45	Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix. ⁶²	Kuroda N...Yanai H	21987295	2013
46	Decreased expression of intercellular adhesion molecules in acantholytic squamous cell carcinoma compared with invasive well-differentiated squamous cell carcinoma of the skin. ⁶²	Griffin JR...Lehman JS	23525614	2013
47	Acantholytic squamous cell carcinoma in upper aerodigestive tract: histopathology, immunohistochemical profile and epithelial mesenchymal transition phenotype change. ⁶²	Gu X...Fowler MR	22850983	2012
48	Acantholytic squamous cell carcinoma of the buccal mucosa: report of a case. ⁶²	Yeoh MS...Ghali GE	22014937	2012
49	Oral adenoid/acantholytic squamous cell carcinoma: a report of two cases with review of literature. ⁶²	Nayak SD...Sequeira J	23434971	2012
50	Collision of atypical fibroxanthoma and acantholytic squamous cell carcinoma in situ. ⁶²	Hyatt AM...Spicknall KE	22728719	2012

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Genes for Adenoid Squamous Cell Carcinoma

Genes related to Adenoid Squamous Cell Carcinoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KRT5	Keratin 5	Protein Coding	5.79	DISEASES inferred ¹⁴
2	KRT8	Keratin 8	Protein Coding	5.55	DISEASES inferred ¹⁴
3	CDH1	Cadherin 1	Protein Coding	5.43	DISEASES inferred ¹⁴
4	KRT7	Keratin 7	Protein Coding	5.41	DISEASES inferred ¹⁴
5	KRT19	Keratin 19	Protein Coding	5.21	DISEASES inferred ¹⁴
6	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	5.15	DISEASES inferred ¹⁴
7	CD34	CD34 Molecule	Protein Coding	5.12	DISEASES inferred ¹⁴
8	EMP2	Epithelial Membrane Protein 2	Protein Coding	5.08	DISEASES inferred ¹⁴
9	DSG3	Desmoglein 3	Protein Coding	4.96	DISEASES inferred ¹⁴
10	TP53	Tumor Protein P53	Protein Coding	4.88	DISEASES inferred ¹⁴
11	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	4.8	DISEASES inferred ¹⁴
12	DSC2	Desmocollin 2	Protein Coding	4.71	DISEASES inferred ¹⁴

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Variations for Adenoid Squamous Cell Carcinoma

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Expression for Adenoid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Adenoid Squamous Cell Carcinoma.

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Pathways for Adenoid Squamous Cell Carcinoma

Pathways related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	COPI-independent Golgi-to-ER retrograde traffic ⁶⁶ Show member pathways Cell cycle Spindle assembly and chromosome separation ²² Cytoskeleton remodeling Keratin filaments ²² Cytoskeleton remodeling Neurofilaments ²² HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand ⁶⁶	12.05	KRT8 KRT7 KRT5 KRT19
2	Cytoskeletal Signaling ³	11.84	KRT8 KRT7 KRT5 KRT19 CDH1
3	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	11.64	KRT8 KRT7 KRT5 KRT19 DSG3 DSC2
4	Signaling mediated by p38-alpha and p38-beta ⁶¹	10.85	TP53 KRT8 KRT19
5	Mammary gland development pathway - Involution (Stage 4 of 4) ⁷⁴	10.32	TP53 CDH1

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GO Terms for Adenoid Squamous Cell Carcinoma

Cellular components related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell junction	GO:0005911	9.7	PECAM1 KRT8 DSG3 DSC2
2	anchoring junction	GO:0070161	9.62	PECAM1 DSG3 DSC2 CDH1
3	extracellular exosome	GO:0070062	9.58	PECAM1 KRT8 KRT7 KRT5 KRT19 DSG3
4	cell periphery	GO:0071944	9.56	KRT8 KRT19 CD34
5	intermediate filament	GO:0005882	9.56	KRT19 KRT5 KRT7 KRT8

Biological processes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell adhesion	GO:0098609	9.96	PECAM1 DSG3 DSC2 CDH1 CD34
2	keratinization	GO:0031424	9.88	KRT8 KRT7 KRT5
3	intermediate filament organization	GO:0045109	9.76	KRT19 KRT5 KRT7 KRT8
4	homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	9.65	PECAM1 DSG3 DSC2 CEACAM5 CDH1
5	glomerular endothelium development	GO:0072011	9.62	PECAM1 CD34
6	cell differentiation involved in embryonic placenta development	GO:0060706	9.54	KRT8 KRT19
7	cell adhesion	GO:0007155	9.28	PECAM1 EMP2 DSG3 DSC2 CEACAM5 CDH1

Molecular functions related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural constituent of skin epidermis	GO:0030280	9.1	KRT8 KRT7 KRT5

Sources

Sources for Adenoid Squamous Cell Carcinoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ADN013 MIFTS: 39	Adenoid Squamous Cell Carcinoma Categories: Cancer diseases, Gastrointestinal diseases, Immune diseases	Data Licensing For inquiries, contact: [email protected]
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