MCID: ADN013
MIFTS: 36

Adenoid Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Adenoid Squamous Cell Carcinoma

MalaCards integrated aliases for Adenoid Squamous Cell Carcinoma:

Name: Adenoid Squamous Cell Carcinoma 12 15
Adenocarcinoma with Squamous Metaplasia 12 73
Acantholytic Squamous Cell Carcinoma 12 73
Pseudoglandular Squamous Carcinoma 12
Adenoacanthoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5524
NCIt 50 C4106 C4200

Summaries for Adenoid Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis.

MalaCards based summary : Adenoid Squamous Cell Carcinoma, also known as adenocarcinoma with squamous metaplasia, is related to acantholytic squamous cell skin carcinoma and endometrial adenocarcinoma. An important gene associated with Adenoid Squamous Cell Carcinoma is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition. The drugs Capecitabine and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and breast.

Related Diseases for Adenoid Squamous Cell Carcinoma

Diseases related to Adenoid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 acantholytic squamous cell skin carcinoma 11.4
2 endometrial adenocarcinoma 11.1
3 ovary adenocarcinoma 10.9
4 adenoiditis 10.6
5 squamous cell carcinoma 10.6
6 biphasic synovial sarcoma 10.5 CDH1 VIM
7 chondroid chordoma 10.5 CDH1 VIM
8 parachordoma 10.5 KRT7 VIM
9 malignant mixed mullerian tumor 10.4 KRT7 VIM
10 nodular hidradenoma 10.4 KRT7 VIM
11 papillary adenoma 10.4 KRT7 VIM
12 benign metastasizing leiomyoma 10.4 KRT7 VIM
13 monophasic synovial sarcoma 10.4 KRT7 VIM
14 spiradenoma 10.4 KRT7 VIM
15 metanephric adenoma 10.4 KRT7 VIM
16 adenomatoid tumor 10.4 KRT7 VIM
17 hidradenoma 10.4 KRT7 VIM
18 renal pelvis adenocarcinoma 10.4 CDH1 KRT7
19 goblet cell carcinoid 10.4 CDH1 KRT20
20 spindle cell sarcoma 10.4 KRT7 VIM
21 morpheaform basal cell carcinoma 10.4 CDH1 KRT20
22 endodermal sinus tumor 10.4 KRT7 VIM
23 dendritic cell tumor 10.4 KRT20 VIM
24 breast adenomyoepithelioma 10.3 CDH1 KRT7
25 breast myoepithelial neoplasm 10.3 CDH1 KRT7
26 cystic basal cell carcinoma 10.3 KRT20 KRT7
27 vaginal benign neoplasm 10.3 KRT20 KRT7
28 seminal vesicle adenocarcinoma 10.3 KRT20 KRT7
29 transverse colon cancer 10.3 KRT20 KRT7
30 appendix adenocarcinoma 10.3 KRT20 KRT7
31 granulosa cell tumor of the ovary 10.3 KRT7 VIM
32 ovarian large-cell neuroendocrine carcinoma 10.3 KRT20 KRT7
33 vaginal adenoma 10.3 KRT20 KRT7
34 vaginal tubulovillous adenoma 10.3 KRT20 KRT7
35 hidradenocarcinoma 10.3 KRT7 VIM
36 eyelid neoplasm 10.3 KRT20 KRT7
37 glandular cystitis 10.3 KRT20 KRT7
38 malignant syringoma 10.3 KRT20 KRT7
39 krukenberg carcinoma 10.3 KRT20 KRT7
40 lung acinar adenocarcinoma 10.3 KRT20 KRT7
41 small cell carcinoma of the bladder 10.3 KRT20 KRT7
42 eccrine sweat gland neoplasm 10.3 KRT20 KRT7
43 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT20 KRT7
44 vulval paget's disease 10.3 KRT20 KRT7
45 bile duct cystadenocarcinoma 10.3 KRT20 KRT7
46 intratubular embryonal carcinoma 10.3 KRT20 KRT7
47 ovarian mucinous adenocarcinoma 10.3 KRT20 KRT7
48 thymus adenocarcinoma 10.3 KRT20 KRT7
49 senile angioma 10.3 HBA1 VIM
50 meibomian cyst 10.3 KRT20 KRT7

Graphical network of the top 20 diseases related to Adenoid Squamous Cell Carcinoma:



Diseases related to Adenoid Squamous Cell Carcinoma

Symptoms & Phenotypes for Adenoid Squamous Cell Carcinoma

Drugs & Therapeutics for Adenoid Squamous Cell Carcinoma

Drugs for Adenoid Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 3,Phase 2 154361-50-9 60953
2
Gemcitabine Approved Phase 3,Phase 2 95058-81-4 60750
3
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
4
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
5
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
6
Doxil Approved June 1999 Phase 3 31703
7 Albumin-Bound Paclitaxel Phase 3
8 Topoisomerase Inhibitors Phase 3
9 Anti-Bacterial Agents Phase 3,Phase 2
10 Antibiotics, Antitubercular Phase 3
11 Immunosuppressive Agents Phase 3,Phase 2
12 Anti-Infective Agents Phase 3,Phase 2
13 Liver Extracts Phase 3,Phase 1
14 Antimetabolites Phase 3,Phase 2
15 Antiviral Agents Phase 3,Phase 2
16 Antimetabolites, Antineoplastic Phase 3,Phase 2
17
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
18
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
19
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
21
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
22 Micronutrients Phase 2
23 Nicotinic Acids Phase 2
24 Trace Elements Phase 2
25 Angiogenesis Inhibitors Phase 2
26 Angiogenesis Modulating Agents Phase 2
27 Vitamin B Complex Phase 2
28 Vitamins Phase 2
29 Protein Kinase Inhibitors Phase 2
30 Folate Nutraceutical Phase 2
31 Vitamin B3 Nutraceutical Phase 2
32 Vitamin B9 Nutraceutical Phase 2
33
Pancrelipase Approved, Investigational Phase 1 53608-75-6
34 pancreatin Phase 1
35 Antibodies Phase 1
36 Immunoglobulins Phase 1
37 Antibodies, Monoclonal Phase 1
38 Cola Nutraceutical Phase 1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer Completed NCT00363584 Phase 3 capecitabine
2 Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Advanced Endometrial Cancer Completed NCT00002493 Phase 3 cisplatin;doxorubicin hydrochloride
3 Comparison of Radiation Therapy With or Without Combination Chemotherapy Following Surgery in Treating Patients With Stage I or Stage II Endometrial Cancer Completed NCT00006027 Phase 3 cisplatin;paclitaxel
4 Gemcitabine With or Without Capecitabine in Treating Patients With Locally Advanced, Unresectable, or Metastatic Biliary Cancer Terminated NCT00658593 Phase 3 capecitabine;gemcitabine hydrochloride
5 Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT01093222 Phase 2 Erlotinib Hydrochloride;Sorafenib Tosylate
6 S0514 Sorafenib in Treating Patients With Unresectable or Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00238212 Phase 2 sorafenib tosylate
7 Thalidomide in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT00025467 Phase 2 thalidomide
8 S0202 Gemcitabine and Capecitabine for Unresectable Locally Advanced Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00033540 Phase 2 capecitabine;gemcitabine hydrochloride
9 Intensity-Modulated Radiation Therapy to the Pelvis With or Without Chemotherapy in Treating Patients With Endometrial Cancer or Cervical Cancer That Has Been Removed By Surgery Completed NCT00331760 Phase 2 cisplatin
10 Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced Gallbladder or Bile Duct Cancer That Cannot Be Removed By Surgery Withdrawn NCT01859182 Phase 2 selumetinib;Akt inhibitor MK2206
11 RAV12 in Treating Patients With Metastatic or Recurrent Adenocarcinoma Completed NCT00101972 Phase 1
12 Gene Therapy in Treating Patients With Cancer Completed NCT00004178 Phase 1

Search NIH Clinical Center for Adenoid Squamous Cell Carcinoma

Genetic Tests for Adenoid Squamous Cell Carcinoma

Anatomical Context for Adenoid Squamous Cell Carcinoma

MalaCards organs/tissues related to Adenoid Squamous Cell Carcinoma:

41
Skin, Liver, Breast, Lung, Tongue

Publications for Adenoid Squamous Cell Carcinoma

Articles related to Adenoid Squamous Cell Carcinoma:

(show all 38)
# Title Authors Year
1
Adenoid Squamous Cell Carcinoma of Oral Cavity: a Case Report. ( 29492419 )
2018
2
Acantholytic squamous cell carcinoma is usually associated with hair follicles, not acantholytic actinic keratosis, and is not "high risk": Diagnosis, management, and clinical outcomes in a series of 115 cases. ( 27889291 )
2017
3
Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma. ( 29085501 )
2017
4
Pulmonary acantholytic squamous cell carcinoma with focal signet ring cell morphology mimicking malignant mesothelioma on fine needle aspiration cytology: a case report. ( 25828595 )
2015
5
Expression of desmosomal proteins in acantholytic squamous cell carcinoma of the skin. ( 25723181 )
2015
6
Adenoid squamous cell carcinoma of the oral cavity. ( 22808297 )
2012
7
Pseudovascular adenoid squamous cell carcinoma of oral cavity: A mimicker of angiosarcoma. ( 22923907 )
2012
8
Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report. ( 19615013 )
2010
9
Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma. ( 18671846 )
2008
10
Primary adenoid squamous cell carcinoma of the oral cavity. ( 16445819 )
2006
11
Pseudovascular adenoid squamous-cell carcinoma of the oral cavity--a report of two cases. ( 17071808 )
2006
12
Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma. ( 16856971 )
2006
13
Immunohistochemical and cytogenetic characterization of acantholytic squamous cell carcinoma of the breast. ( 15668805 )
2005
14
The expression of syndecan-1 is preferentially reduced compared with that of E-cadherin in acantholytic squamous cell carcinoma. ( 11168756 )
2001
15
A case of adenoid squamous cell carcinoma of the breast skin. ( 11341233 )
2000
16
Primary adenoid squamous cell carcinoma of the upper lip associated with a locoregional metastasis: a case report and review of the literature. ( 10319839 )
1999
17
Fine-needle aspiration cytologic features of pseudovascular adenoid squamous-cell carcinoma of the lung. ( 10495320 )
1999
18
A Case of Adenoid Squamous Cell Carcinoma of the Breast Skin. ( 11091718 )
1999
19
A case of pseudovascular adenoid squamous cell carcinoma of the skin with spindle cell pattern. ( 9350106 )
1997
20
Mucosal adenoid squamous cell carcinoma of the head and neck. ( 8651637 )
1996
21
Pseudovascular adenoid squamous cell carcinoma of the lung: clinicopathologic study of three cases and comparison with true pleuropulmonary angiosarcoma. ( 8163270 )
1994
22
Oral adenoid squamous cell carcinoma: a report of three cases and review of the literature. ( 8492207 )
1993
23
Pseudovascular adenoid squamous cell carcinoma of the skin. A neoplasm that may be mistaken for angiosarcoma. ( 1599022 )
1992
24
Adenoid Squamous Cell Carcinoma. ( 28134144 )
1988
25
Adenoid squamous cell carcinoma of the skin overlying the right breast. An autopsy case clinically manifested with rapid growth and widely spreading metastases. ( 3825538 )
1986
26
Adenoid squamous cell carcinoma of the nasopharynx and neck region. ( 3518653 )
1986
27
A clinicopathologic study of 21 cases of adenoid squamous cell carcinoma of the eyelid and periorbital region. ( 3976805 )
1985
28
Adenoid squamous cell carcinoma of the penis. Report of a surgical case clinically manifested with rapid lung metastasis. ( 6670557 )
1983
29
Adenosquamous carcinoma of skin appendages (adenoid squamous cell carcinoma, pseudoglandular squamous cell carcinoma, adenocanthoma of sweat gland of Lever) of the vulva: a clinical and ultrastructural study. ( 709534 )
1978
30
Adenoid squamous cell carcinoma of the oral cavity: report of the first case arising in the tongue. ( 880122 )
1977
31
Adenoid squamous cell carcinoma of the oral mucosa: report of two autopsy cases. ( 922664 )
1977
32
Adenoid squamous-cell carcinoma of vermilion mucosa of lower lip. ( 4521951 )
1974
33
Adenoid squamous cell carcinoma of the vulva. ( 4810097 )
1974
34
Adenoid squamous cell carcinoma of the lip: report of cases. ( 4504554 )
1972
35
Multiple adenoid squamous cell carcinoma. ( 5093173 )
1971
36
Adenoid squamous-cell carcinoma (adenocanthoma) of the oral labial mucosa. A clinicopathologic study of fifteen cases. ( 5285191 )
1971
37
Adenoid squamous cell carcinoma (adenoacanthoma). A clinicopathologic study of 155 patients. ( 5927198 )
1966
38
ADENOID SQUAMOUS CELL CARCINOMA (ADENOACANTHOMA OF LEVER). REPORT OF SEVEN CASES AND REVIEW. ( 14107628 )
1964

Variations for Adenoid Squamous Cell Carcinoma

Expression for Adenoid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Adenoid Squamous Cell Carcinoma.

Pathways for Adenoid Squamous Cell Carcinoma

Pathways related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 CDH1 KRT20 KRT7 VIM
2 10.21 CDH1 VIM

GO Terms for Adenoid Squamous Cell Carcinoma

Cellular components related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT20 KRT7 VIM

Biological processes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 8.62 KRT20 VIM

Sources for Adenoid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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