MCID: ADN013
MIFTS: 39

Adenoid Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Immune diseases
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Aliases & Classifications for Adenoid Squamous Cell Carcinoma

MalaCards integrated aliases for Adenoid Squamous Cell Carcinoma:

Name: Adenoid Squamous Cell Carcinoma 11 14
Adenocarcinoma with Squamous Metaplasia 11 71
Acantholytic Squamous Cell Carcinoma 11 71
Pseudoglandular Squamous Carcinoma 11
Adenoacanthoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:5524
NCIt 49 C4200
SNOMED-CT 68 15176003 85956000
UMLS 71 C0334250 C0334393

Summaries for Adenoid Squamous Cell Carcinoma

Disease Ontology: 11 A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis.

MalaCards based summary: Adenoid Squamous Cell Carcinoma, also known as adenocarcinoma with squamous metaplasia, is related to ovary adenocarcinoma and angiosarcoma. An important gene associated with Adenoid Squamous Cell Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and Cytoskeletal Signaling. The drugs Erlotinib and Sorafenib have been mentioned in the context of this disorder. Affiliated tissues include ovary, lymph node and cervix, and related phenotypes are Increased shRNA abundance (Z-score > 2) and digestive/alimentary

Related Diseases for Adenoid Squamous Cell Carcinoma

Diseases related to Adenoid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 531)
# Related Disease Score Top Affiliating Genes
1 ovary adenocarcinoma 30.9 TP53 KRT7 CEACAM5 CDH1
2 angiosarcoma 30.9 PECAM1 KRT8 CD34
3 skin squamous cell carcinoma 30.5 TP53 KRT5 CDH1
4 basosquamous carcinoma 30.3 TP53 KRT7
5 lip and oral cavity cancer 30.1 TP53 KRT19 CDH1
6 mucoepidermoid carcinoma 30.1 KRT8 KRT7 KRT19 CDH1
7 acanthoma 30.1 TP53 KRT5
8 adenosquamous carcinoma 30.0 KRT8 KRT7 KRT5 KRT19 CEACAM5
9 squamous cell carcinoma 30.0 TP53 KRT7 KRT19 CEACAM5 CDH1
10 cystadenofibroma 30.0 TP53 KRT7
11 basaloid squamous cell carcinoma 29.9 TP53 KRT8 KRT7 KRT5
12 adenoma 29.9 TP53 KRT7 KRT19 CDH1
13 adenoid cystic carcinoma 29.8 TP53 KRT7 KRT19 CDH1
14 mucinous ovarian cystadenoma 29.8 KRT7 CEACAM5
15 mesothelioma, malignant 29.8 KRT7 KRT5 CEACAM5 CDH1
16 paget disease, extramammary 29.8 KRT7 KRT5 KRT19 CEACAM5
17 benign mesothelioma 29.8 KRT7 KRT5 KRT19 CEACAM5
18 gallbladder adenocarcinoma 29.7 TP53 KRT7 CEACAM5
19 interstitial lung disease 2 29.7 TP53 PECAM1 CDH1 CD34
20 papilloma 29.7 TP53 KRT8 KRT7 KRT5 CDH1
21 small cell cancer of the lung 29.7 TP53 KRT7 CEACAM5
22 skin carcinoma 29.7 TP53 KRT8 KRT7 KRT5 CDH1
23 thyroid gland follicular carcinoma 29.5 TP53 KRT7 KRT19 CDH1
24 signet ring cell adenocarcinoma 29.5 TP53 KRT7 CEACAM5 CDH1
25 hemangioma 29.5 TP53 PECAM1 KRT7 CDH1 CD34
26 adenocarcinoma 29.5 TP53 KRT7 CEACAM5 CDH1
27 breast ductal carcinoma 29.5 TP53 KRT8 KRT7 KRT5 KRT19 CDH1
28 keratoacanthoma 29.5 TP53 KRT8 KRT19 DSG3 CDH1
29 esophageal adenosquamous carcinoma 29.3 TP53 KRT7 KRT5 CEACAM5 CDH1
30 papillary adenocarcinoma 29.2 TP53 KRT7 KRT5 CEACAM5
31 breast adenocarcinoma 28.8 TP53 PECAM1 KRT8 KRT7 KRT5 CEACAM5
32 pancreatic cancer 28.3 TP53 PECAM1 KRT8 KRT7 KRT19 CEACAM5
33 acantholytic squamous cell skin carcinoma 11.5
34 endometrial adenocarcinoma 11.2
35 squamous cell carcinoma, head and neck 10.5
36 endometrial cancer 10.4
37 vulva squamous cell carcinoma 10.4
38 breast adenomyoepithelioma 10.3 KRT7 KRT5
39 lymphoepithelioma-like thymic carcinoma 10.3 KRT8 KRT5
40 laryngeal adenoid cystic carcinoma 10.3 KRT7 KRT5
41 inverted transitional papilloma 10.3 KRT7 KRT5
42 microinvasive cervical squamous cell carcinoma 10.3 KRT7 KRT5
43 ceruminoma 10.3 KRT7 KRT5
44 prostatic urethral cancer 10.3 KRT7 KRT5
45 rete testis neoplasm 10.3 KRT7 KRT5
46 rectum squamous cell carcinoma 10.3 KRT7 KRT5
47 middle ear adenoma 10.3 KRT7 KRT5
48 rete testis adenocarcinoma 10.3 KRT7 KRT5
49 auditory system benign neoplasm 10.3 KRT7 KRT5
50 breast mucoepidermoid carcinoma 10.3 KRT7 KRT5

Graphical network of the top 20 diseases related to Adenoid Squamous Cell Carcinoma:



Diseases related to Adenoid Squamous Cell Carcinoma

Symptoms & Phenotypes for Adenoid Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

25 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.04 PECAM1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.04 PECAM1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.04 PECAM1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.04 KRT8
5 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.04 KRT5 PECAM1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.04 KRT8 KRT7
7 Increased shRNA abundance (Z-score > 2) GR00366-A-14 10.04 EMP2 PECAM1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.04 PECAM1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.04 KRT5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.04 EMP2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-17 10.04 KRT5
12 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.04 EMP2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.04 EMP2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-180 10.04 EMP2 KRT5 KRT8 PECAM1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.04 KRT8 KRT7
16 Increased shRNA abundance (Z-score > 2) GR00366-A-200 10.04 KRT5
17 Increased shRNA abundance (Z-score > 2) GR00366-A-211 10.04 PECAM1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.04 PECAM1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.04 EMP2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-40 10.04 KRT8
21 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.04 PECAM1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-44 10.04 EMP2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.04 EMP2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.04 PECAM1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.04 PECAM1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-68 10.04 KRT7
27 Increased shRNA abundance (Z-score > 2) GR00366-A-72 10.04 KRT7
28 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.04 EMP2 KRT8 KRT7
29 Increased shRNA abundance (Z-score > 2) GR00366-A-75 10.04 PECAM1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-91 10.04 KRT5 KRT7

MGI Mouse Phenotypes related to Adenoid Squamous Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 CDH1 CEACAM5 DSC2 DSG3 KRT19 KRT5
2 cellular MP:0005384 9.81 CD34 CDH1 CEACAM5 DSC2 DSG3 KRT19
3 cardiovascular system MP:0005385 9.56 CDH1 CEACAM5 DSC2 EMP2 KRT19 KRT8
4 immune system MP:0005387 9.36 CD34 CDH1 CEACAM5 DSC2 DSG3 EMP2

Drugs & Therapeutics for Adenoid Squamous Cell Carcinoma

Drugs for Adenoid Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Erlotinib Approved, Investigational Phase 2 183319-69-9, 183321-74-6 176870
2
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239
3
Thalidomide Approved, Investigational, Withdrawn Phase 2 50-35-1 5426
4 Protein Kinase Inhibitors Phase 2
5 Anti-Bacterial Agents Phase 2
6 Anti-Infective Agents Phase 2
7 Angiogenesis Inhibitors Phase 2
8 Immunosuppressive Agents Phase 2
9 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Sorafenib (NSC-724772) and Erlotinib (NSC-718781) in Patients With Advanced Gallbladder Carcinoma or Cholangiocarcinoma Completed NCT01093222 Phase 2 Erlotinib Hydrochloride;Sorafenib Tosylate
2 Phase II Study of BAY 43-9006 (NSC #724772) as Single Agent in Unresectable or Metastatic Gallbladder Carcinoma and Cholangiocarcinoma Completed NCT00238212 Phase 2 sorafenib tosylate
3 A Phase II Evaluation of Thalidomide (NSC #66847, IND 48832) in the Treatment of Recurrent of Persistent Endometrial Carcinoma Completed NCT00025467 Phase 2 thalidomide
4 A Multicenter Phase II Study of the Combination of AZD6244 Hydrogen Sulfate and MK-2206 in Patients With Refractory Advanced Biliary Cancers Withdrawn NCT01859182 Phase 2 selumetinib;Akt inhibitor MK2206

Search NIH Clinical Center for Adenoid Squamous Cell Carcinoma

Genetic Tests for Adenoid Squamous Cell Carcinoma

Anatomical Context for Adenoid Squamous Cell Carcinoma

Organs/tissues related to Adenoid Squamous Cell Carcinoma:

MalaCards : Ovary, Lymph Node, Cervix, Uterus, Breast, Colon, Skin

Publications for Adenoid Squamous Cell Carcinoma

Articles related to Adenoid Squamous Cell Carcinoma:

(show top 50) (show all 390)
# Title Authors PMID Year
1
Intra-oral Acantholytic Squamous Cell Carcinoma: 55 Cases. Is this Variant more Aggressive? 62
34378166 2022
2
Acantholytic Squamous Cell Carcinoma Arising From Lichen Sclerosus: A Rare Case Affecting Vulvar Skin. 62
34015795 2022
3
Acantholytic variant of squamous cell carcinoma in the mandible: A rare entity and a brief review. 62
36321707 2022
4
Sonographic and pathological features of metaplastic squamous cell carcinoma of the breast: a case series. 62
34688286 2021
5
Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Paget disease? A unifying concept and review of the literature. 62
33893742 2021
6
Pseudovascular Adenoid Squamous Cell Carcinoma of Buccal Mucosa-a Rare Aggressive Variant. 62
34295075 2021
7
Expression of Heat Shock Protein 105 in Cutaneous Squamous Cell Carcinoma: Correlation with Clinicopathological Characteristics. 62
34163202 2021
8
Pulmonary Acantholytic Squamous Cell Carcinoma Mimicking Lepidic Pattern Adenocarcinoma. 62
32282054 2021
9
Adenoid (Acantholytic) Squamous Cell Carcinoma of Mandibular Gingiva. 62
34336306 2021
10
Adenoid squamous cell carcinoma of upper lip, a rare variant of squamous cell carcinoma: A case report. 62
33532433 2020
11
A rare acantholytic variant of squamous cell carcinoma of the maxilla: A case report and literature review. 62
32769927 2020
12
Acantholytic Squamous Cell Carcinoma and Salivary Duct Carcinoma Ex-pleomorphic Adenoma of the Submandibular Gland: A Report of Two Extremely Rare Cases with an Immunohistochemical Analysis. 62
30484070 2020
13
Pseudovascular adenoid squamous cell carcinoma of the tongue: a case report and literature review. 62
32509083 2020
14
Oral variant of acantholytic squamous cell carcinoma-Histochemical and immunohistochemical features. 62
31706621 2019
15
Characteristic imaging findings of acantholytic squamous cell carcinoma: a case report. 62
30798506 2019
16
Angiotropism in recurrent cutaneous squamous cell carcinoma: Implications for regional tumor recurrence and extravascular migratory spread. 62
30414196 2019
17
Morphologic mimicry: acantholytic squamous cell carcinoma in nondermal locations-a literature review. 62
29744885 2018
18
Shadow Cell Differentiation: A Comparative Analysis of Modes of Cell Death with Apoptosis and Epidermal/Trichilemmal Keratinization. 62
30197883 2018
19
Acantholytic squamous cell carcinoma of the gallbladder mimicking adenocarcinoma. 62
29671927 2018
20
Adenoid Squamous Cell Carcinoma of Oral Cavity: a Case Report. 62
29492419 2018
21
Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report. 62
29548309 2018
22
Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma. 62
29085501 2017
23
Metastasis of a Renal Collecting Duct Adenocarcinoma to the Oral Cavity After Tooth Extraction. 62
28489662 2017
24
Acantholytic squamous cell carcinoma is usually associated with hair follicles, not acantholytic actinic keratosis, and is not "high risk": Diagnosis, management, and clinical outcomes in a series of 115 cases. 62
27889291 2017
25
[Esophageal adenocarcinoma: the clinicopathologic features, patterns of lymph node metastasis and its influencing factors]. 62
27531265 2016
26
Acantholytic squamous cell carcinoma of soft palate-case report and literature review. 62
30894973 2016
27
[Acantholytic squamous cell carcinoma of larynx as an uncommon variant of squamous cell carcinoma]. 62
27107606 2016
28
Acantholytic squamous cell carcinoma of the oesophagus with prevalent single isolated tumour cells including signet ring cells and many osteoclast-like giant cells. 62
27020507 2016
29
Acantholytic-Like Pattern in a Recurrent Melanoma Mimicking Acantholytic Squamous Cell Carcinoma: A Further Example Highlighting the Potential for Misdiagnosis. 62
26999345 2016
30
Pulmonary acantholytic squamous cell carcinoma with focal signet ring cell morphology mimicking malignant mesothelioma on fine needle aspiration cytology: a case report. 62
25828595 2016
31
Acantholytic squamous cell carcinoma of the lung showing significant signet ring cell component. 62
26109084 2016
32
[Auricular Acantholytic Squamous Cell Carcinoma with Neck Metastasis and Lethal Outcome - Case Report]. 62
26727870 2015
33
Expression of desmosomal proteins in acantholytic squamous cell carcinoma of the skin. 62
25723181 2015
34
Primary angiomatoid melanoma as an exceptional morphologic pattern in cutaneous melanoma. A case report and review of the literature. 62
25498159 2015
35
Pseudoepitheliomatous changes in a case of vegetating Darier–White disease: a unique histopathological finding. 62
25238450 2015
36
Shadow cell differentiation from squamoid morule in endometrial adenoacanthoma. 62
26722510 2015
37
Adenoid dysplasia of the oral mucosa. 62
25442496 2014
38
Desmosomal defects in acantholytic squamous cell carcinomas. 62
25264142 2014
39
Two different scenarios of squamous cell carcinoma within advanced Basal cell carcinomas: cases illustrating the importance of serial biopsy during vismodegib usage. 62
24740281 2014
40
Acantholytic squamous cell carcinoma of the oral cavity: A rare entity. 62
25364162 2014
41
Acantholytic squamous cell carcinoma: pathological study of nine cases with review of literature. 62
24969975 2014
42
Acantholytic squamous cell carcinoma arising in a nevus sebaceous: A case report. 62
24533028 2013
43
Toxicology and Carcinogenesis Studies of Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine (3TC), and Nevirapine (NVP) (CAS Nos. 30516-87-1, 134678-17-4, 129618-40-2) in Genetically Modified C3B6.129F1-Trp53(tm1Brd) N12 Haploinsufficient Mice (in utero and postnatal gavage studies). 62
24503698 2013
44
Acantholytic squamous cell carcinoma of the maxilla: unusual location and aggressive behavior of a rare histologic variant. 62
24057911 2013
45
Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix. 62
21987295 2013
46
Decreased expression of intercellular adhesion molecules in acantholytic squamous cell carcinoma compared with invasive well-differentiated squamous cell carcinoma of the skin. 62
23525614 2013
47
Acantholytic squamous cell carcinoma in upper aerodigestive tract: histopathology, immunohistochemical profile and epithelial mesenchymal transition phenotype change. 62
22850983 2012
48
Acantholytic squamous cell carcinoma of the buccal mucosa: report of a case. 62
22014937 2012
49
Oral adenoid/acantholytic squamous cell carcinoma: a report of two cases with review of literature. 62
23434971 2012
50
Collision of atypical fibroxanthoma and acantholytic squamous cell carcinoma in situ. 62
22728719 2012

Variations for Adenoid Squamous Cell Carcinoma

Expression for Adenoid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Adenoid Squamous Cell Carcinoma.

Pathways for Adenoid Squamous Cell Carcinoma

Pathways related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.05 KRT8 KRT7 KRT5 KRT19
2 11.84 KRT8 KRT7 KRT5 KRT19 CDH1
3
Show member pathways
11.64 KRT8 KRT7 KRT5 KRT19 DSG3 DSC2
4 10.85 TP53 KRT8 KRT19
5 10.32 TP53 CDH1

GO Terms for Adenoid Squamous Cell Carcinoma

Cellular components related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 9.7 PECAM1 KRT8 DSG3 DSC2
2 anchoring junction GO:0070161 9.62 PECAM1 DSG3 DSC2 CDH1
3 extracellular exosome GO:0070062 9.58 PECAM1 KRT8 KRT7 KRT5 KRT19 DSG3
4 cell periphery GO:0071944 9.56 KRT8 KRT19 CD34
5 intermediate filament GO:0005882 9.56 KRT19 KRT5 KRT7 KRT8

Biological processes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell adhesion GO:0098609 9.96 PECAM1 DSG3 DSC2 CDH1 CD34
2 keratinization GO:0031424 9.88 KRT8 KRT7 KRT5
3 intermediate filament organization GO:0045109 9.76 KRT19 KRT5 KRT7 KRT8
4 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.65 PECAM1 DSG3 DSC2 CEACAM5 CDH1
5 glomerular endothelium development GO:0072011 9.62 PECAM1 CD34
6 cell differentiation involved in embryonic placenta development GO:0060706 9.54 KRT8 KRT19
7 cell adhesion GO:0007155 9.28 PECAM1 EMP2 DSG3 DSC2 CEACAM5 CDH1

Molecular functions related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of skin epidermis GO:0030280 9.1 KRT8 KRT7 KRT5

Sources for Adenoid Squamous Cell Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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