MCID: ADN013
MIFTS: 38

Adenoid Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Adenoid Squamous Cell Carcinoma

MalaCards integrated aliases for Adenoid Squamous Cell Carcinoma:

Name: Adenoid Squamous Cell Carcinoma 12 15
Adenocarcinoma with Squamous Metaplasia 12 70
Acantholytic Squamous Cell Carcinoma 12 70
Pseudoglandular Squamous Carcinoma 12
Adenoacanthoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5524
NCIt 50 C4106 C4200
SNOMED-CT 67 15176003 85956000
UMLS 70 C0334250 C0334393

Summaries for Adenoid Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis.

MalaCards based summary : Adenoid Squamous Cell Carcinoma, also known as adenocarcinoma with squamous metaplasia, is related to endometrial adenocarcinoma and in situ carcinoma. An important gene associated with Adenoid Squamous Cell Carcinoma is CDH1 (Cadherin 1), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Thalidomide and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Adenoid Squamous Cell Carcinoma

Diseases related to Adenoid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 394)
# Related Disease Score Top Affiliating Genes
1 endometrial adenocarcinoma 31.5 KRT7 EMP2 CDH1
2 in situ carcinoma 30.5 KRT8 KRT5 CDH1
3 adenosquamous carcinoma 30.5 KRT8 KRT7 KRT5 KRT19
4 eyelid carcinoma 30.5 KRT7 KRT20
5 signet ring cell adenocarcinoma 30.4 KRT7 KRT20 CDH1
6 esophageal adenosquamous carcinoma 30.3 KRT7 KRT5 CDH1
7 mammary paget's disease 30.3 KRT8 KRT7 KRT20
8 vascular cancer 30.2 PECAM1 KRT7 CD34
9 mesothelioma, malignant 30.1 VIM KRT7 KRT20 CDH1
10 cystadenofibroma 30.1 KRT7 KRT5
11 angiosarcoma 30.0 VIM PECAM1 KRT8 KRT7 CD34
12 basaloid squamous cell carcinoma 30.0 KRT8 KRT7 KRT20 KRT19
13 mucoepidermoid carcinoma 30.0 KRT7 KRT5 KRT19 CDH1
14 papilloma 30.0 KRT8 KRT7 KRT5 KRT20
15 papillary adenocarcinoma 29.8 VIM KRT7 KRT19 CDH1
16 hemangioma 29.8 VIM PECAM1 KRT7 CD34
17 adenoid cystic carcinoma 29.5 VIM KRT7 KRT5 KRT20 KRT19 CDH1
18 benign mesothelioma 29.4 VIM PECAM1 KRT7 KRT5 KRT20 KRT19
19 acantholytic squamous cell skin carcinoma 11.5
20 ovary adenocarcinoma 11.0
21 squamous cell carcinoma 10.6
22 goblet cell carcinoid 10.4 KRT20 CDH1
23 thymus lipoma 10.4 KRT20 KRT19
24 immune system organ benign neoplasm 10.4 KRT20 KRT19
25 regional odontodysplasia 10.3 VIM KRT19
26 morpheaform basal cell carcinoma 10.3 KRT20 KRT19
27 idiopathic corneal edema 10.3 KRT8 KRT19
28 breast cystic hypersecretory carcinoma 10.3 KRT5 CDH1
29 gallbladder signet ring cell adenocarcinoma 10.3 KRT7 CDH1
30 thymus adenocarcinoma 10.3 KRT5 KRT20
31 pericardial mesothelioma 10.3 VIM KRT19
32 urethral villous adenoma 10.3 KRT7 KRT20
33 bladder benign neoplasm 10.3 KRT7 KRT20
34 nephrogenic adenoma of urinary bladder 10.3 KRT7 KRT20
35 atrophic vulva 10.3 KRT7 KRT20
36 pancreatic serous cystadenocarcinoma 10.3 KRT7 KRT20
37 urinary bladder villous adenoma 10.3 KRT7 KRT20
38 vulva adenocarcinoma 10.3 KRT7 KRT20
39 vaginal tubulovillous adenoma 10.3 KRT7 KRT20
40 female urethral cancer 10.3 KRT7 KRT20
41 cystitis cystica 10.3 KRT7 KRT20
42 mucinous ovarian cystadenoma 10.3 KRT7 KRT20
43 rectosigmoid junction neoplasm 10.3 KRT7 KRT20
44 transverse colon cancer 10.3 KRT7 KRT20
45 sigmoid neoplasm 10.3 KRT7 KRT20
46 krukenberg carcinoma 10.3 KRT7 KRT20
47 urinary bladder small cell neuroendocrine carcinoma 10.3 KRT7 KRT20
48 apocrine adenocarcinoma 10.3 KRT7 KRT5
49 biphasic synovial sarcoma 10.3 VIM CDH1
50 jejunal cancer 10.3 KRT7 KRT20

Graphical network of the top 20 diseases related to Adenoid Squamous Cell Carcinoma:



Diseases related to Adenoid Squamous Cell Carcinoma

Symptoms & Phenotypes for Adenoid Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 44)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 10.02 PECAM1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 10.02 VIM
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 10.02 VIM
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.02 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-176 10.02 VIM
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 10.02 KRT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-190 10.02 VIM
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 10.02 PECAM1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-2 10.02 PECAM1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 10.02 VIM
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 10.02 VIM
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-30 10.02 VIM
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 10.02 KRT8
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 10.02 KRT5 KRT7 KRT8
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-85 10.02 VIM
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 10.02 PECAM1 VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.85 PECAM1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.85 PECAM1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.85 PECAM1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.85 KRT8
21 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.85 KRT5 PECAM1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.85 KRT8
23 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.85 EMP2 PECAM1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.85 PECAM1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.85 KRT5
26 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.85 EMP2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-17 9.85 KRT5
28 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.85 EMP2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.85 EMP2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.85 EMP2 KRT5 KRT8 PECAM1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.85 KRT8
32 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.85 KRT5
33 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.85 PECAM1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.85 PECAM1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.85 EMP2
36 Increased shRNA abundance (Z-score > 2) GR00366-A-40 9.85 KRT8
37 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.85 PECAM1
38 Increased shRNA abundance (Z-score > 2) GR00366-A-44 9.85 EMP2
39 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.85 EMP2
40 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.85 PECAM1
41 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.85 PECAM1
42 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.85 EMP2 KRT8
43 Increased shRNA abundance (Z-score > 2) GR00366-A-75 9.85 PECAM1
44 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.85 KRT5

MGI Mouse Phenotypes related to Adenoid Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.65 CD34 CDH1 DSG3 EMP2 KRT19 KRT5
2 digestive/alimentary MP:0005381 9.63 CDH1 DSG3 KRT19 KRT5 KRT8 PECAM1
3 reproductive system MP:0005389 9.17 CDH1 DSG3 EMP2 KRT19 KRT8 SDC1

Drugs & Therapeutics for Adenoid Squamous Cell Carcinoma

Drugs for Adenoid Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thalidomide Approved, Investigational, Withdrawn Phase 2 50-35-1 5426
2 Anti-Infective Agents Phase 2
3 Immunosuppressive Agents Phase 2
4 Angiogenesis Inhibitors Phase 2
5 Immunologic Factors Phase 2
6 Anti-Bacterial Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Evaluation of Thalidomide (NSC #66847, IND 48832) in the Treatment of Recurrent of Persistent Endometrial Carcinoma Completed NCT00025467 Phase 2 thalidomide

Search NIH Clinical Center for Adenoid Squamous Cell Carcinoma

Genetic Tests for Adenoid Squamous Cell Carcinoma

Anatomical Context for Adenoid Squamous Cell Carcinoma

MalaCards organs/tissues related to Adenoid Squamous Cell Carcinoma:

40
Breast, Skin, Liver, Thyroid, Colon, Thymus, Heart

Publications for Adenoid Squamous Cell Carcinoma

Articles related to Adenoid Squamous Cell Carcinoma:

(show top 50) (show all 69)
# Title Authors PMID Year
1
Adenoid squamous cell carcinoma of upper lip, a rare variant of squamous cell carcinoma: A case report. 61
33532433 2020
2
Pseudovascular adenoid squamous cell carcinoma of the tongue: a case report and literature review. 61
32509083 2020
3
Adenoid Squamous Cell Carcinoma of Oral Cavity: a Case Report. 61
29492419 2018
4
Metastasis of a Renal Collecting Duct Adenocarcinoma to the Oral Cavity After Tooth Extraction. 61
28489662 2017
5
Expression of desmosomal proteins in acantholytic squamous cell carcinoma of the skin. 61
25723181 2015
6
Primary angiomatoid melanoma as an exceptional morphologic pattern in cutaneous melanoma. A case report and review of the literature. 61
25498159 2015
7
Oral adenoid/acantholytic squamous cell carcinoma: a report of two cases with review of literature. 61
23434971 2012
8
Pseudovascular adenoid squamous cell carcinoma of oral cavity: A mimicker of angiosarcoma. 61
22923907 2012
9
Adenoid squamous cell carcinoma of the oral cavity. 61
22808297 2012
10
Clinicopathological analysis of ten patients with metaplastic squamous cell carcinoma of the breast. 61
21365411 2011
11
Acantholytic squamous cell carcinoma of the gingiva: report of a case and review of the literature. 61
20451835 2010
12
Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis. 61
18714362 2008
13
Pseudovascular adenoid squamous-cell carcinoma of the oral cavity--a report of two cases. 61
17071808 2006
14
Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma. 61
16856971 2006
15
Primary adenoid squamous cell carcinoma of the oral cavity. 61
16445819 2006
16
Squamous cell carcinoma variants of the upper aerodigestive tract. 61
16468420 2005
17
Pathological study of naturally occurring adenocarcinomas demonstrating differentiation in ducks. 61
15763726 2004
18
[Oral adenoid squemous carcinoma. Tumor markers and prognosis]. 61
15045535 2004
19
Does human papilloma virus have a role in squamous cell carcinoma of the colon and upper rectum? 61
12359204 2002
20
A case of adenoid squamous cell carcinoma of the breast skin. 61
11341233 2000
21
Molecular pathology and clinicopathologic features of penile tumors: with special reference to analyses of p21 and p53 expression and unusual histologic features. 61
10506441 1999
22
Fine-needle aspiration cytologic features of pseudovascular adenoid squamous-cell carcinoma of the lung. 61
10495320 1999
23
Endometrial carcinoma associated with pregnancy: A report of three cases and review of the literature. 61
10385562 1999
24
A Case of Adenoid Squamous Cell Carcinoma of the Breast Skin. 61
11091718 1999
25
Primary adenoid squamous cell carcinoma of the upper lip associated with a locoregional metastasis: a case report and review of the literature. 61
10319839 1999
26
[Metaplastic tumors of the breast: a case of primary squamous cell carcinoma]. 61
10396865 1999
27
[Extra-neoplastic epithelial changes in cancer of the vulva]. 61
10726352 1999
28
Primary squamous cell carcinoma of the breast in a young woman--a case report and review of literature. 61
9866914 1998
29
Laryngeal cancer in Lower Silesia: descriptive analysis of 501 cases. 61
9861343 1998
30
Human papillomavirus and mixed epithelial tumors of the endometrium. 61
9563789 1998
31
Adenoid squamous carcinoma of the conjunctiva--a clinicopathological study of 14 cases. 61
9505827 1997
32
A case of pseudovascular adenoid squamous cell carcinoma of the skin with spindle cell pattern. 61
9350106 1997
33
Angiosarcoma at unusual sites. A report of two cases with aspiration cytology and diagnostic pitfalls. 61
9167711 1997
34
Mucin-producing adenoma associated with pancreas divisum and hepatic hilar carcinoma: an autopsy case. 61
8726842 1996
35
Mucosal adenoid squamous cell carcinoma of the head and neck. 61
8651637 1996
36
Primary squamous cell carcinoma of the breast. 61
8638180 1996
37
The many faces of squamous cell carcinoma. 61
8599736 1996
38
Basaloid squamous cell carcinoma of the head and neck: clinicopathological features and differential diagnosis. 61
8546432 1996
39
Fine-needle aspiration cytology of adenoid (acantholytic) squamous-cell carcinoma. 61
7774500 1995
40
Female genital tract cancer. 61
8001001 1995
41
Characterization and radiosensitivity of UT-EC-2A and UT-EC-2B, two new highly radiosensitive endometrial cancer cell lines derived from a primary and metastatic tumor of the same patient. 61
7821848 1995
42
Postoperative high dose-rate intravaginal brachytherapy combined with external irradiation for early stage endometrial cancer: a long-term follow-up. 61
7960984 1994
43
Pseudovascular adenoid squamous cell carcinoma of the lung: clinicopathologic study of three cases and comparison with true pleuropulmonary angiosarcoma. 61
8163270 1994
44
Oral adenoid squamous cell carcinoma: a report of three cases and review of the literature. 61
8492207 1993
45
Pseudovascular adenoid squamous cell carcinoma of the skin. A neoplasm that may be mistaken for angiosarcoma. 61
1599022 1992
46
Pure squamous cell carcinoma of the breast. 61
2038438 1991
47
Adenoid Squamous Cell Carcinoma. 61
28134144 1988
48
Adenoid squamous cell carcinoma of the skin overlying the right breast. An autopsy case clinically manifested with rapid growth and widely spreading metastases. 61
3825538 1986
49
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. 61
2429552 1986
50
Adenoid squamous cell carcinoma of the nasopharynx and neck region. 61
3518653 1986

Variations for Adenoid Squamous Cell Carcinoma

Expression for Adenoid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Adenoid Squamous Cell Carcinoma.

Pathways for Adenoid Squamous Cell Carcinoma

Pathways related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 KRT8 KRT7 KRT5 KRT20 KRT19 DSG3
2
Show member pathways
12.09 KRT8 KRT7 KRT5 KRT20 KRT19 DSG3
3
Show member pathways
11.8 SDC1 PECAM1 CDH1
4 11.73 SDC1 PECAM1 CDH1 CD34
5 11.66 VIM KRT8 KRT7 KRT5 KRT20 KRT19
6
Show member pathways
11.56 VIM DSG3 CDH1
7
Show member pathways
11.39 VIM KRT8 KRT7 KRT5 KRT19
8 10.62 VIM CDH1

GO Terms for Adenoid Squamous Cell Carcinoma

Cellular components related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.61 VIM SDC1 PECAM1 KRT8 KRT7 KRT5
2 keratin filament GO:0045095 9.43 KRT8 KRT7 KRT5
3 apicolateral plasma membrane GO:0016327 9.4 KRT8 KRT19
4 costamere GO:0043034 9.37 KRT8 KRT19
5 cell periphery GO:0071944 9.33 KRT8 KRT19 CD34
6 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT8 KRT19
7 intermediate filament GO:0005882 9.1 VIM KRT8 KRT7 KRT5 KRT20 KRT19

Biological processes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.77 PECAM1 EMP2 DSG3 CDH1 CD34
2 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.61 PECAM1 DSG3 CDH1
3 cell-cell adhesion GO:0098609 9.56 PECAM1 DSG3 CDH1 CD34
4 keratinization GO:0031424 9.43 KRT8 KRT7 KRT5 KRT20 KRT19 DSG3
5 intermediate filament organization GO:0045109 9.4 VIM KRT20
6 cell differentiation involved in embryonic placenta development GO:0060706 9.32 KRT8 KRT19
7 glomerular endothelium development GO:0072011 9.16 PECAM1 CD34
8 cornification GO:0070268 9.1 KRT8 KRT7 KRT5 KRT20 KRT19 DSG3

Molecular functions related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.13 VIM KRT8 KRT5
2 structural constituent of cytoskeleton GO:0005200 8.92 VIM KRT5 KRT20 KRT19

Sources for Adenoid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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