Aliases & Classifications for Adenoiditis

MalaCards integrated aliases for Adenoiditis:

Name: Adenoiditis 12 15 73
Chronic Adenoiditis 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050145
ICD10 33 J35.02
ICD9CM 35 474.01
SNOMED-CT 68 195794009 232420002

Summaries for Adenoiditis

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.

MalaCards based summary : Adenoiditis, also known as chronic adenoiditis, is related to adenoid hypertrophy and adenoid cystic carcinoma, and has symptoms including pain, redness and swelling. An important gene associated with Adenoiditis is FCN2 (Ficolin 2). The drugs Dexmedetomidine and Mannitol have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, breast and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Adenoiditis is the inflammation of the adenoid tissue, usually caused by an infection. Adenoiditis is... more...

Related Diseases for Adenoiditis

Diseases related to Adenoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 adenoid hypertrophy 12.5
2 adenoid cystic carcinoma 12.4
3 cervical adenoid cystic carcinoma 12.1
4 trachea adenoid cystic carcinoma 12.0
5 lung adenoid cystic carcinoma 12.0
6 maxillary sinus adenoid cystic carcinoma 12.0
7 prostate adenoid cystic carcinoma 12.0
8 lacrimal gland adenoid cystic carcinoma 12.0
9 adenoid basal cell carcinoma 12.0
10 breast adenoid cystic carcinoma 12.0
11 esophageal adenoid cystic carcinoma 12.0
12 laryngeal adenoid cystic carcinoma 12.0
13 bartholin's gland adenoid cystic carcinoma 12.0
14 adenoid squamous cell carcinoma 12.0
15 parotid gland adenoid cystic carcinoma 12.0
16 ethmoid sinus adenoid cystic carcinoma 11.9
17 adenoid basal carcinoma of the cervix uteri 11.9
18 lymph node adenoid cystic carcinoma 11.8
19 cervical adenoid basal carcinoma 11.8
20 adenoid cystic carcinoma of the corpus uteri 11.8
21 sublingual gland adenoid cystic carcinoma 11.8
22 trichoepithelioma, multiple familial, 1 11.7
23 tonsillitis 11.6
24 multiple familial trichoepithelioma 11.5
25 cutaneous adenocystic carcinoma 11.4
26 sleep apnea 11.2
27 brooke-spiegler syndrome 11.2
28 paranasal sinus cancer 11.1
29 prostate cancer 10.8
30 prostate cancer, hereditary, 1 10.8
31 hurler syndrome 10.8
32 hurler-scheie syndrome 10.8
33 prostate cancer, hereditary, 12 10.8
34 prostate cancer, hereditary, 13 10.8
35 prostate cancer, hereditary, 11 10.8
36 prostate cancer, hereditary, 2 10.8
37 plague 10.8
38 calcifying epithelial odontogenic tumor 10.8
39 squamous cell carcinoma 10.4
40 adenocarcinoma 10.3
41 otitis media 10.3
42 adenoma 10.2
43 polymorphous low-grade adenocarcinoma 10.2
44 pleomorphic adenoma 10.2
45 basal cell carcinoma 1 10.2
46 basal cell carcinoma 10.2
47 mucoepidermoid carcinoma 10.1
48 rhinitis 10.1
49 allergic rhinitis 10.1
50 nasopharyngitis 10.1

Graphical network of the top 20 diseases related to Adenoiditis:



Diseases related to Adenoiditis

Symptoms & Phenotypes for Adenoiditis

Symptoms:

12
  • pain
  • redness
  • swelling
  • difficulty swallowing

GenomeRNAi Phenotypes related to Adenoiditis according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.7 LY75
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.7 TYROBP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.7 LY75
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.7 LY75
5 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.7 CARD9
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.7 CARD9
7 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.7 TYROBP LY75
8 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.7 CARD9
9 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.7 LY75
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.7 LY75
11 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.7 CARD9
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 CARD9
13 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.7 TYROBP CARD9
14 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.7 CARD9
15 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.7 CARD9
16 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.7 TYROBP
17 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.7 LY75
18 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.7 LY75
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.26 CARD9
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.26 CARD9 CNOT4
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.26 CNOT4

MGI Mouse Phenotypes related to Adenoiditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 8.92 CARD9 CNOT4 LY75 TYROBP

Drugs & Therapeutics for Adenoiditis

Drugs for Adenoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
2
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
3
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
4
Propyl Gallate Investigational Phase 4 121-79-9 4947
5 Adrenergic Agents Phase 4
6 Adrenergic Agonists Phase 4
7 Adrenergic alpha-2 Receptor Agonists Phase 4
8 Adrenergic alpha-Agonists Phase 4
9 Analgesics Phase 4
10 Analgesics, Non-Narcotic Phase 4
11 Central Nervous System Depressants Phase 4
12 Hypnotics and Sedatives Phase 4
13 Neurotransmitter Agents Phase 4
14 Peripheral Nervous System Agents Phase 4
15 Pharmaceutical Solutions Phase 4
16 Broncho-Vaxom Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
2 Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy Not yet recruiting NCT03243565 Phase 4

Search NIH Clinical Center for Adenoiditis

Genetic Tests for Adenoiditis

Anatomical Context for Adenoiditis

MalaCards organs/tissues related to Adenoiditis:

41
Salivary Gland, Breast, Lung, Tonsil, Trachea, Skin, Tongue

Publications for Adenoiditis

Articles related to Adenoiditis:

(show top 50) (show all 1112)
# Title Authors Year
1
Ameloblastoma with adenoid features: A series of eight cases. ( 29799420 )
2018
2
Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis. ( 29970966 )
2018
3
Effects of para-toluenesulfonamide intratumoral injection on pulmonary adenoid cystic carcinoma complicating with severe central airway obstruction: a 5-year follow-up study. ( 29850151 )
2018
4
Liver resection for metastases of tracheal adenoid cystic carcinoma: Report of two cases. ( 29778031 )
2018
5
Genetic rearrangements, hotspot mutations, and microRNA expression in the progression of metastatic adenoid cystic carcinoma of the salivary gland. ( 29731974 )
2018
6
Reply to the letter to the author concerning: 'Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?' ( 29423746 )
2018
7
Central airway obstruction caused by adenoid cystic carcinoma in pregnancy: a case report and review of the literature. ( 29721318 )
2018
8
Adenoid Squamous Cell Carcinoma of Oral Cavity: a Case Report. ( 29492419 )
2018
9
Inhibitory effect of chidamide on the growth of human adenoid cystic carcinoma cells. ( 29710459 )
2018
10
Deregulation of Nicotinamide N-Methyltransferase and Gap Junction Protein Alpha-1 Causes Metastasis in Adenoid Cystic Carcinoma. ( 29277772 )
2018
11
EGFR activation induced Snail-dependent EMT and myc-dependent PD-L1 in human salivary adenoid cystic carcinoma cells. ( 29954240 )
2018
12
Ataxia-Telangiectasia-Mutated Protein Expression as a Prognostic Marker in Adenoid Cystic Carcinoma of the Salivary Glands. ( 29978608 )
2018
13
Discordant correlation of breast adenoid cystic carcinoma on imaging and pathology: A case report and literature review on surgical management. ( 29268125 )
2018
14
Potential biological functions of microvesicles derived from adenoid cystic carcinoma. ( 29725477 )
2018
15
Expression of PIM-1 in salivary gland adenoid cystic carcinoma: Association with tumor progression and patients' prognosis. ( 29399171 )
2018
16
3D-printing aided resection of intratracheal adenoid cystic carcinoma and mediastinal mature cystic teratoma in a 26-year-old female: a case report. ( 29607203 )
2018
17
Innate immunity gene expression by epithelial cells of upper respiratory tract in children with adenoid hypertrophy. ( 29500040 )
2018
18
miR-93-5p enhance lacrimal gland adenoid cystic carcinoma cell tumorigenesis by targeting BRMS1L. ( 29760585 )
2018
19
Dedifferentiated adenoid cystic carcinoma ex pleomorphic adenoma of the parotid. ( 29893347 )
2018
20
Alterations of Notch pathway in patients with adenoid cystic carcinoma of the trachea and its impact on survival. ( 29858025 )
2018
21
IGFBP2 promotes salivary adenoid cystic carcinoma metastasis by activating the NF-I_B/ZEB1 signaling pathway. ( 29885520 )
2018
22
Immunohistochemical Expression of CD-117 (c-KIT), P-53 and Ki-67 in Adenoid Cystic Carcinoma of Palate. ( 29866247 )
2018
23
Effect of survivin downregulation by simvastatin on the growth and invasion of salivary adenoid cystic carcinoma. ( 29956779 )
2018
24
Evaluation of choroidal thickness in children with adenoid hypertrophy. ( 29313145 )
2018
25
Primary Cutaneous Adenoid Cystic Carcinoma Connecting to the Epidermis. ( 29742556 )
2018
26
Sinonasal adenoid cystic carcinoma-role of on-site FNAC: a case report. ( 29760580 )
2018
27
Establishment and characterization of a carcinoma-associated fibroblast cell line derived from a human salivary gland adenoid cystic carcinoma. ( 29734861 )
2018
28
Superficial punctate keratopathy in a pediatric patient was related to adenoid hypertrophy and obstructive sleep apnea syndrome: a case report. ( 29471795 )
2018
29
In reply to &amp;quot;Commentary to: Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease&amp;quot;, by Zhengcai Lou. ( 29423745 )
2018
30
Molecular features of adenoid cystic carcinoma with an emphasis on microRNA expression. ( 29924420 )
2018
31
Algorithm of adenoiditis treatment in adults, depending on the pharyngeal tonsil hypertrophy stage. ( 29783226 )
2018
32
A Comparative Study of Primary Adenoid Cystic and Mucoepidermoid Carcinoma of Lung. ( 29868475 )
2018
33
A Case of Adenoid Cystic Carcinoma Mimicking a Bartholin Cyst and Literature Review. ( 29780648 )
2018
34
Risk factors and prognosis for salivary gland adenoid cystic carcinoma in southern china: A 25-year retrospective study. ( 28151884 )
2017
35
Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776. ( 28228352 )
2017
36
Halitosis in children with adenoid hypertrophy. ( 29146888 )
2017
37
Clinicopathological characteristics of KIT and protein kinase C-I' expression in adenoid cystic carcinoma: comparison with chromophobe renal cell carcinoma and gastrointestinal stromal tumour. ( 28561935 )
2017
38
Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis. ( 28600602 )
2017
39
Mithramycin inhibits epithelial-to-mesenchymal transition and invasion by downregulating SP1 and SNAI1 in salivary adenoid cystic carcinoma. ( 28631560 )
2017
40
Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors. ( 27870570 )
2017
41
Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: A randomized controlled trial. ( 28098165 )
2017
42
Significant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population. ( 28263490 )
2017
43
MYB Labeling by Immunohistochemistry Is More Sensitive and Specific for Breast Adenoid Cystic Carcinoma than MYB Labeling by FISH. ( 28498281 )
2017
44
Adenoids in paediatric chronic rhinosinusitis, deep neck space infections and optimising otowicks in otitis externa. ( 28841132 )
2017
45
Investigation of resectability degree for adenoidal surgery in OSA children with the method of computational fluid dynamics. ( 27684180 )
2017
46
B7-H3 regulates migration and invasion in salivary gland adenoid cystic carcinoma via the JAK2/STAT3 signaling pathway. ( 28386362 )
2017
47
Correction: Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. ( 28642227 )
2017
48
HIF1I+ in Tumorigenesis of Adenoid Cystic Carcinoma. ( 28179306 )
2017
49
Breast adenoid cystic carcinoma: report of a case with emphasis on routine sonographic findings and shear wave elastography. ( 28382475 )
2017
50
Adenoid Cystic Carcinoma of Maxillary Sinus Misdiagnosed as Chronic Apical Periodontitis. ( 28236426 )
2017

Variations for Adenoiditis

Expression for Adenoiditis

Search GEO for disease gene expression data for Adenoiditis.

Pathways for Adenoiditis

GO Terms for Adenoiditis

Biological processes related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 8.96 CARD9 FCN2
2 innate immune response GO:0045087 8.8 CARD9 FCN2 TYROBP

Molecular functions related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.62 FCN2 LY75

Sources for Adenoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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