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MCID: ADN002
MIFTS: 29

Adenoiditis

Categories: Respiratory diseases
Genes Variations Tissues Related diseases Publications Drugs
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Aliases & Classifications for Adenoiditis

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MalaCards integrated aliases for Adenoiditis:

Name: Adenoiditis 12 15 73
Chronic Adenoiditis 12 6 73

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
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Disease Ontology 12 DOID:0050145
ICD10 33 J35.02
ICD9CM 35 474.01
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Summaries for Adenoiditis

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Disease Ontology : 12 An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.

MalaCards based summary : Adenoiditis, also known as chronic adenoiditis, is related to adenoid hypertrophy and adenoid cystic carcinoma. An important gene associated with Adenoiditis is FCN2 (Ficolin 2). The drugs Dexmedetomidine and Mannitol have been mentioned in the context of this disorder. Affiliated tissues include tonsil, lung and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Adenoiditis is the inflammation of the adenoid tissue, usually caused by an infection. Adenoiditis is... more...

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Related Diseases for Adenoiditis

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Diseases related to Adenoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 adenoid hypertrophy 12.6
2 adenoid cystic carcinoma 12.6
3 cervical adenoid cystic carcinoma 12.4
4 prostate adenoid cystic carcinoma 12.2
5 trachea adenoid cystic carcinoma 12.2
6 lung adenoid cystic carcinoma 12.2
7 maxillary sinus adenoid cystic carcinoma 12.2
8 lacrimal gland adenoid cystic carcinoma 12.2
9 adenoid basal cell carcinoma 12.2
10 breast adenoid cystic carcinoma 12.2
11 esophageal adenoid cystic carcinoma 12.2
12 laryngeal adenoid cystic carcinoma 12.2
13 bartholin's gland adenoid cystic carcinoma 12.1
14 adenoid squamous cell carcinoma 12.1
15 parotid gland adenoid cystic carcinoma 12.1
16 ethmoid sinus adenoid cystic carcinoma 12.0
17 cervical adenoid basal carcinoma 12.0
18 adenoid basal carcinoma of the cervix uteri 12.0
19 lymph node adenoid cystic carcinoma 12.0
20 adenoid cystic carcinoma of the corpus uteri 12.0
21 sublingual gland adenoid cystic carcinoma 11.9
22 trichoepithelioma, multiple familial, 1 11.9
23 tonsillitis 11.8
24 multiple familial trichoepithelioma 11.6
25 cutaneous adenocystic carcinoma 11.6
26 sleep apnea 11.3
27 paranasal sinus cancer 11.3
28 prostate cancer 11.0
29 prostate cancer, hereditary, 1 11.0
30 hurler syndrome 11.0
31 hurler-scheie syndrome 11.0
32 prostate cancer, hereditary, 12 11.0
33 prostate cancer, hereditary, 13 11.0
34 prostate cancer, hereditary, 11 11.0
35 prostate cancer, hereditary, 2 11.0
36 plague 11.0
37 ceruminous adenocarcinoma 11.0
38 calcifying epithelial odontogenic tumor 11.0
39 squamous cell carcinoma 10.5
40 otitis media 10.5
41 adenocarcinoma 10.4
42 adenoma 10.4
43 pleomorphic adenoma 10.4
44 polymorphous low-grade adenocarcinoma 10.4
45 basal cell carcinoma 1 10.3
46 basal cell carcinoma 10.3
47 rhinitis 10.2
48 allergic rhinitis 10.2
49 ameloblastoma 10.2
50 mucoepidermoid carcinoma 10.2

Graphical network of the top 20 diseases related to Adenoiditis:



Diseases related to Adenoiditis
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Symptoms & Phenotypes for Adenoiditis

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GenomeRNAi Phenotypes related to Adenoiditis according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.68 LY75
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.68 TYROBP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.68 LY75
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.68 LY75
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.68 CARD9
6 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.68 TYROBP LY75
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.68 CARD9
8 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.68 LY75
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.68 LY75
10 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.68 CARD9
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.68 CARD9
12 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.68 CARD9 TYROBP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.68 CARD9
14 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.68 CARD9
15 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.68 TYROBP
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.68 LY75
17 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.68 LY75
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.35 CARD9
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.35 CARD9
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.35 CARD9 CNOT4
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.35 CNOT4

MGI Mouse Phenotypes related to Adenoiditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.26 CARD9 CNOT4 LY75 TYROBP
2 immune system MP:0005387 8.92 CARD9 CNOT4 LY75 TYROBP
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Drugs & Therapeutics for Adenoiditis

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Drugs for Adenoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
2
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
3
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
4
Propyl Gallate Investigational Phase 4 121-79-9 4947
5 Adrenergic alpha-Agonists Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Analgesics Phase 4
8 Adrenergic Agents Phase 4
9 Pharmaceutical Solutions Phase 4
10 Central Nervous System Depressants Phase 4
11 Adrenergic alpha-2 Receptor Agonists Phase 4
12 Adrenergic Agonists Phase 4
13 Neurotransmitter Agents Phase 4
14 Hypnotics and Sedatives Phase 4
15 Peripheral Nervous System Agents Phase 4
16 Broncho-Vaxom Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
2 Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy Not yet recruiting NCT03243565 Phase 4

Search NIH Clinical Center for Adenoiditis

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Genetic Tests for Adenoiditis

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Anatomical Context for Adenoiditis

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MalaCards organs/tissues related to Adenoiditis:

41
Tonsil, Lung, Breast, Pituitary, Prostate, Cervix, Thyroid
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Publications for Adenoiditis

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Articles related to Adenoiditis:

(show all 26)
# Title Authors Year
1
In reply to &amp;quot;Commentary to: Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease&amp;quot;, by Zhengcai Lou. ( 29423745 )
2018
2
Algorithm of adenoiditis treatment in adults, depending on the pharyngeal tonsil hypertrophy stage. ( 29783226 )
2018
3
&amp;quot;Commentary to: 'Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease'&amp;quot;? ( 28474190 )
2017
4
Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease. ( 27695944 )
2016
5
Nonencapsulated Streptococcus pneumoniae as a cause of chronic adenoiditis. ( 27144125 )
2016
6
FCN2 c.772G&amp;gt;T polymorphism is associated with chronic adenoiditis and/or tonsillitis, but notA -4 A&amp;gt;G andA -602A G&amp;gt;A. ( 27368434 )
2016
7
Possible role of apoptosis in pathogenesis of adenoid hypertrophy and chronic adenoiditis: Prospective case-control study. ( 26003878 )
2015
8
Prevalence of microorganisms and immunoglobulins in children with tonsillar hypertrophy and adenoiditis. ( 25992111 )
2014
9
The utility of nasopharyngeal culture in the management of chronic adenoiditis. ( 22784508 )
2012
10
Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis. ( 22339566 )
2012
11
Association of adenoid hyperplasia and bacterial biofilm formation in children with adenoiditis in Taiwan. ( 21779840 )
2012
12
Diagnostic accuracy of nasopharyngeal swabs in detecting biofilm-producing bacteria in chronic adenoiditis: a preliminary study. ( 21493370 )
2011
13
Ribosomal therapy in the treatment of recurrent acute adenoiditis. ( 20052587 )
2010
14
Role of adenoids and adenoiditis in children with allergy and otitis media. ( 19814919 )
2009
15
Increased risk of otitis media with effusion in allergic children presenting with adenoiditis. ( 18439460 )
2008
16
The 10-day mark is a good way to diagnose not only acute rhinosinusitis but also adenoiditis, as confirmed by endoscopy. ( 17239449 )
2007
17
Spatial organisation of microbiota in quiescent adenoiditis and tonsillitis. ( 16698947 )
2007
18
Invasive fungal adenoiditis. ( 16564404 )
2006
19
Nasal endoscopy in asthmatic children: assessment of rhinosinusitis and adenoiditis incidence, correlations with cytology and microbiology. ( 11359430 )
2001
20
Sore throat, tonsillitis, and adenoiditis. ( 9927961 )
1999
21
What is wrong in chronic adenoiditis/tonsillitis immunological factor. ( 10577792 )
1999
22
What is wrong in chronic adenoiditis/tonsillitis anatomical considerations. ( 10577791 )
1999
23
Acute suppurative adenoiditis. ( 2773892 )
1989
24
Nasal obstruction. Adenoiditis vs adenoid hypertrophy. ( 7200351 )
1982
25
Suppurative adenoiditis. ( 13542062 )
1958
26
Respiratory obstruction caused by acute tonsillitis and acute adenoiditis. ( 13334825 )
1956
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Variations for Adenoiditis

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ClinVar genetic disease variations for Adenoiditis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NOTCH1 NM_017617.5(NOTCH1): c.2458C> T (p.Pro820Ser) single nucleotide variant Uncertain significance GRCh38 Chromosome 9, 136513030: 136513030
2 NOTCH1 NM_017617.5(NOTCH1): c.2458C> T (p.Pro820Ser) single nucleotide variant Uncertain significance GRCh37 Chromosome 9, 139407482: 139407482
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Expression for Adenoiditis

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Search GEO for disease gene expression data for Adenoiditis.
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Pathways for Adenoiditis

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GO Terms for Adenoiditis

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Biological processes related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 8.96 CARD9 FCN2
2 innate immune response GO:0045087 8.8 CARD9 FCN2 TYROBP

Molecular functions related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.62 FCN2 LY75
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Sources for Adenoiditis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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