Aliases & Classifications for Adenoiditis

MalaCards integrated aliases for Adenoiditis:

Name: Adenoiditis 12 15 72
Chronic Adenoiditis 12 6 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050145
ICD9CM 35 474.01
ICD10 33 J35.02
UMLS 72 C0001427 C0396023

Summaries for Adenoiditis

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.

MalaCards based summary : Adenoiditis, also known as chronic adenoiditis, is related to lymphoma, non-hodgkin, familial and adenoid hypertrophy. An important gene associated with Adenoiditis is FCN2 (Ficolin 2), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include tonsil, colon and testes, and related phenotypes are no effect and Decreased viability in HMC1.1 cells

Wikipedia : 75 Adenoiditis is the inflammation of the adenoid tissue it's usually caused by an infection. Adenoiditis... more...

Related Diseases for Adenoiditis

Diseases related to Adenoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 552)
# Related Disease Score Top Affiliating Genes
1 lymphoma, non-hodgkin, familial 29.3 SYK NOTCH1 MALT1 BCL10
2 adenoid hypertrophy 12.8
3 adenoid cystic carcinoma 12.8
4 cervical adenoid cystic carcinoma 12.6
5 maxillary sinus adenoid cystic carcinoma 12.4
6 trachea adenoid cystic carcinoma 12.4
7 lacrimal gland adenoid cystic carcinoma 12.4
8 prostate adenoid cystic carcinoma 12.4
9 breast adenoid cystic carcinoma 12.4
10 lung adenoid cystic carcinoma 12.4
11 laryngeal adenoid cystic carcinoma 12.3
12 adenoid basal cell carcinoma 12.3
13 cervical adenoid basal carcinoma 12.3
14 parotid gland adenoid cystic carcinoma 12.3
15 esophageal adenoid cystic carcinoma 12.3
16 adenoid basal carcinoma of the cervix uteri 12.3
17 bartholin's gland adenoid cystic carcinoma 12.3
18 adenoid squamous cell carcinoma 12.3
19 ethmoid sinus adenoid cystic carcinoma 12.2
20 lymph node adenoid cystic carcinoma 12.1
21 adenoid cystic carcinoma of the corpus uteri 12.1
22 sublingual gland adenoid cystic carcinoma 12.1
23 trichoepithelioma, multiple familial, 1 12.0
24 tonsillitis 12.0
25 paranasal sinus cancer 11.8
26 sleep apnea 11.6
27 prostate cancer 11.5
28 calcifying epithelial odontogenic tumor 11.5
29 cutaneous adenocystic carcinoma 11.4
30 multiple familial trichoepithelioma 11.3
31 prostate cancer, hereditary, 1 11.2
32 hurler syndrome 11.2
33 hurler-scheie syndrome 11.2
34 prostate cancer, hereditary, 12 11.2
35 prostate cancer, hereditary, 13 11.2
36 prostate cancer, hereditary, 11 11.2
37 prostate cancer, hereditary, 2 11.2
38 plague 11.2
39 ceruminous adenocarcinoma 11.2
40 otitis media 10.9
41 rare tumor 10.7
42 adenoma 10.7
43 pleomorphic adenoma 10.6
44 squamous cell carcinoma 10.6
45 rhinitis 10.6
46 adenocarcinoma 10.6
47 haemophilus influenzae 10.6
48 allergic rhinitis 10.5
49 basal cell carcinoma 10.5
50 polymorphous low-grade adenocarcinoma 10.5

Graphical network of the top 20 diseases related to Adenoiditis:



Diseases related to Adenoiditis

Symptoms & Phenotypes for Adenoiditis

GenomeRNAi Phenotypes related to Adenoiditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 BCL10 CARD9 CD209 CD68 CD69 CLEC7A
2 Decreased viability in HMC1.1 cells GR00105-A-0 8.96 ITK SRC

MGI Mouse Phenotypes related to Adenoiditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.19 BCL10 CARD9 CD68 CD69 CLEC7A CNOT4
2 cellular MP:0005384 10.11 BCL10 CD69 FKBP4 GNAS HAVCR2 ITK
3 immune system MP:0005387 10.09 BCL10 CARD9 CD68 CD69 CLEC7A CNOT4
4 endocrine/exocrine gland MP:0005379 9.97 BCL10 FKBP4 GNAS ITK NOTCH1 SRC
5 mortality/aging MP:0010768 9.73 BCL10 CLEC7A CNOT4 FKBP4 GNAS HAVCR2
6 skeleton MP:0005390 9.23 CD68 CD69 CNOT4 GNAS NOTCH1 SRC

Drugs & Therapeutics for Adenoiditis

Drugs for Adenoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Correlation Between Adenoid Hypertrophy and Body Temperature in Children Before and After Adenoidectomy Unknown status NCT02965183
2 Analysis of Clinical, Pathologic and Molecular Markers of Adenotonsillar Hypertrophic Disease Completed NCT03541434
3 Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children Recruiting NCT03336671
4 Does the Technique of Adenoidectomy Influence the Results of the Surgery? A Prospective Randomized Single Blind Study Active, not recruiting NCT03760341
5 A Prospective, Randomized, Double-blinded, Controlled Study to Evaluate Use of the PEAK PlasmaBlade TnA in Subcapsular Tonsillectomy Terminated NCT01193556

Search NIH Clinical Center for Adenoiditis

Genetic Tests for Adenoiditis

Anatomical Context for Adenoiditis

MalaCards organs/tissues related to Adenoiditis:

41
Tonsil, Colon, Testes

Publications for Adenoiditis

Articles related to Adenoiditis:

(show top 50) (show all 164)
# Title Authors PMID Year
1
Can Symptoms Differentiate Between Chronic Adenoiditis and Chronic Rhinosinusitis in Pediatric Patients. 38
30939913 2019
2
Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review. 38
30616011 2019
3
Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease. 38
31086039 2019
4
An overview on upper respiratory tract infections and bacteriotherapy as innovative therapeutic strategy. 38
30920638 2019
5
The efficacy and tolerability of Streptococcus salivarius 24SMB and Streptococcus oralis 89a administered as nasal spray in the treatment of recurrent upper respiratory tract infections in children. 38
30920629 2019
6
Biofilm Formations in Pediatric Respiratory Tract Infection : Part 1: Biofilm Structure, Role of Innate Immunity in Protection Against and Response to Biofilm, Methods of Biofilm Detection, Pediatric Respiratory Tract Diseases Associated with Mucosal Biofilm Formation. 38
30820766 2019
7
[Tactics of conservative treatment of chronic adenoiditis in children]. 38
31198213 2019
8
[Fungal adenoiditis and tonsillomycosis in children: features of diagnosis and therapy]. 38
31198221 2019
9
"Commentary to: 'Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease'"? 38
28474190 2018
10
In reply to "Commentary to: Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease", by Zhengcai Lou. 38
29423745 2018
11
[Possibilities of treatment of inflammatory pathology of the nasopharynx in children with chronic adenoiditis and otitis media with effusion]. 38
30721181 2018
12
Phenotype Profiling and Allergy in Otitis-Prone Children. 38
30564563 2018
13
Algorithm of adenoiditis treatment in adults, depending on the pharyngeal tonsil hypertrophy stage. 38
29783226 2018
14
Immune thrombocytopenia of childhood responsive to tonsillectomy in the setting of chronic tonsillitis: A case report and literature review. 38
28648251 2017
15
Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease. 38
27695944 2017
16
Inhaled Antibiotic Therapy for the Treatment of Upper Respiratory Tract Infections. 38
27336220 2017
17
Topical administration of hyaluronic acid in children with recurrent or chronic middle ear inflammations. 38
27481884 2016
18
FCN2 c.772G>T polymorphism is associated with chronic adenoiditis and/or tonsillitis, but not -4 A>G and -602 G>A. 38
27368434 2016
19
Paediatric nasopharyngeal cytology: a new diagnostic opportunity? 38
27039342 2016
20
Endoscopic Adenoidectomy in Children With Otitis Media With Effusion and Mild Hearing Loss. 38
26976024 2016
21
Clinical Practice Guideline: Otitis Media with Effusion (Update). 38
26832942 2016
22
Nasal nitric oxide in children with recurrent acute otitis media. 38
27049104 2016
23
Nonencapsulated Streptococcus pneumoniae as a cause of chronic adenoiditis. 38
27144125 2016
24
[Monitoring of microflora localized at the pharyngeal tonsil surface in the children residing in the city of Chelyabinsk and presenting with chronic adenoiditis]. 38
26977565 2016
25
[ADRENERGIC AND CHOLINERGIC INNERVATION OF THE PHARYNGEAL TONSILS IN CHILDREN WITH CHRONIC ADENOIDITIS]. 38
30136789 2016
26
[The possibilities for the rational pharmacotherapy of adenoiditis in the children]. 38
27876743 2016
27
Possible role of apoptosis in pathogenesis of adenoid hypertrophy and chronic adenoiditis: Prospective case-control study. 38
26003878 2015
28
[Clinical, significance of the nomenclature for nasal septum tail: A preliminary study]. 38
26685402 2015
29
Nasopharyngeal and Adenoid Colonization by Haemophilus influenzae and Haemophilus parainfluenzae in Children Undergoing Adenoidectomy and the Ability of Bacterial Isolates to Biofilm Production. 38
25950686 2015
30
[The analysis of the influence of the adenoiditis treatment by different methods on the nasopharyngeal microbiocenosis in the children]. 38
26525324 2015
31
[Prophylaxis of chronic adenoiditis in the children]. 38
26978751 2015
32
Clinical consensus statement: pediatric chronic rhinosinusitis. 38
25274375 2014
33
Utility of antimicrobial susceptibility testing of multiple Haemophilus influenzae isolates from throat swabs of children with adenoid hypertrophy. 38
24815933 2014
34
Prevalence of microorganisms and immunoglobulins in children with tonsillar hypertrophy and adenoiditis. 38
25992111 2014
35
Acquired absolute vitamin K deficiency in a patient undergoing warfarin therapy. 38
24439543 2014
36
Safety of adult tonsillectomy: a population-level analysis of 5968 patients. 38
24481159 2014
37
Can computed tomography score predict outcome of adenoidectomy for chronic rhinosinusitis in children. 38
24717893 2014
38
[The influence of local and combined acute suppurative Highmore maxillary sinusitis on the serum lactoferrin and interleukin-8 levels in the children]. 38
25588485 2014
39
Molar incisor hypomineralization, prevalence, and etiology. 38
24949012 2014
40
[The comparative effectiveness of framycetin included in combined therapy of adenoiditis in the children]. 38
25588492 2014
41
[The experimentally-based rationale for the application of the new methods designed to treat fungal adenoiditis in the children]. 38
25377679 2014
42
[Effectiveness of a herbal preparation tonsilgon N for the treatment of children presenting with chronic adenoiditis]. 38
24781178 2014
43
[The morphofunctional prerequisites for the development of exudative otitis media in the children presenting with chronic adenoiditis]. 38
25377676 2014
44
[The possibilities for the treatment of exudative otitis media in the children presenting with chronic adenoiditis]. 38
25734311 2014
45
C-type lectin receptors mRNA expression in patients with otitis media with effusion. 38
24094722 2013
46
The presentation and clinical significance of sinonasal respiratory epithelial adenomatoid hamartoma (REAH). 38
23038055 2013
47
Topographic distribution of biofilm-producing bacteria in adenoid subsites of children with chronic or recurrent middle ear infections. 38
23534125 2013
48
Adenoid ciliostimulation in children with chronic otitis media. 38
23032917 2013
49
[Laryngopharyngeal reflux as a possible cause of adenoiditis in adult patients]. 38
23887376 2013
50
[The effectiveness of rinorin introduced in the combined treatment of chronic adenoiditis in the children]. 38
23715494 2013

Variations for Adenoiditis

ClinVar genetic disease variations for Adenoiditis:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 NOTCH1 NM_017617.5(NOTCH1): c.2458C> T (p.Pro820Ser) single nucleotide variant Uncertain significance 9:139407482-139407482 9:136513030-136513030

Expression for Adenoiditis

Search GEO for disease gene expression data for Adenoiditis.

Pathways for Adenoiditis

Pathways related to Adenoiditis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 TYROBP TREM1 SYK SRC MALT1 ITK
2
Show member pathways
13.21 TYROBP TREM1 SYK SRC MALT1 ITK
3
Show member pathways
12.99 TYROBP TREM1 SYK SRC MALT1 GNAS
4
Show member pathways
12.72 SYK SRC MALT1 ITK BCL10
5 12.32 TYROBP SYK MALT1 ITK HAVCR2 CARD9
6
Show member pathways
12.16 SYK MALT1 ITK BCL10
7
Show member pathways
12.11 SYK SRC MALT1 CLEC7A CD209 CARD9
8
Show member pathways
11.98 TYROBP TREM1 SYK SRC ITK GNAS
9 11.83 SYK SRC GNAS
10 11.75 SYK SRC MALT1 CLEC7A CD209 CARD9
11
Show member pathways
11.73 MALT1 ITK BCL10
12 11.73 NOTCH1 CD69 CD68 CD209
13 11.68 SYK MALT1 BCL10
14
Show member pathways
11.41 SYK SRC MALT1 CLEC7A CD209 CARD9
15 10.77 SRC NOTCH1
16 10.66 SYK SRC

GO Terms for Adenoiditis

Cellular components related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.55 SYK MALT1 FKBP4 CD69 BCL10
2 cell surface GO:0009986 9.35 TYROBP NOTCH1 HAVCR2 CD69 CD209
3 CBM complex GO:0032449 8.62 MALT1 BCL10

Biological processes related to Adenoiditis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.88 TSPO SRC GNAS CARD9
2 intracellular signal transduction GO:0035556 9.85 TYROBP TREM1 SYK SRC ITK CD209
3 adaptive immune response GO:0002250 9.83 SYK ITK HAVCR2 CD209 BCL10
4 immune system process GO:0002376 9.81 SYK SRC ITK HAVCR2 FCN2 CLEC7A
5 T cell receptor signaling pathway GO:0050852 9.76 MALT1 ITK BCL10
6 defense response to Gram-positive bacterium GO:0050830 9.73 HAVCR2 FCN2 CARD9
7 integrin-mediated signaling pathway GO:0007229 9.72 TYROBP SYK SRC
8 Fc-epsilon receptor signaling pathway GO:0038095 9.71 SYK MALT1 ITK BCL10
9 cellular defense response GO:0006968 9.67 TYROBP ITK BCL10
10 positive regulation of interleukin-4 production GO:0032753 9.59 SYK HAVCR2
11 negative regulation of anoikis GO:2000811 9.57 SRC NOTCH1
12 response to muramyl dipeptide GO:0032495 9.54 NOTCH1 CARD9
13 response to molecule of bacterial origin GO:0002237 9.52 MALT1 BCL10
14 negative regulation of glial cell proliferation GO:0060253 9.51 TSPO NOTCH1
15 macrophage activation involved in immune response GO:0002281 9.5 TYROBP SYK HAVCR2
16 regulation of T cell receptor signaling pathway GO:0050856 9.48 MALT1 BCL10
17 neutrophil activation involved in immune response GO:0002283 9.46 TYROBP SYK
18 response to fungus GO:0009620 9.43 MALT1 CARD9 BCL10
19 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.43 SYK SRC MALT1 CD209 CARD9 BCL10
20 innate immune response GO:0045087 9.32 TYROBP TREM1 SYK MALT1 HAVCR2 FCN2

Molecular functions related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CARD domain binding GO:0050700 9.32 CARD9 BCL10
2 kinase activator activity GO:0019209 9.16 MALT1 BCL10
3 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.13 SYK SRC ITK
4 carbohydrate binding GO:0030246 9.02 LY75 FCN2 CLEC7A CD69 CD209
5 protein binding GO:0005515 10.19 TYROBP TSPO SYK SRC NOTCH1 MALT1

Sources for Adenoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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