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MCID: ADN002
MIFTS: 33

Adenoiditis

Categories: Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adenoiditis

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MalaCards integrated aliases for Adenoiditis:

Name: Adenoiditis 12 15 71
Chronic Adenoiditis 12 6 71

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
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External Ids:

Disease Ontology 12 DOID:0050145
ICD9CM 34 474.01
ICD10 32 J35.02
UMLS 71 C0001427 C0396023
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Summaries for Adenoiditis

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Disease Ontology : 12 An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.

MalaCards based summary : Adenoiditis, also known as chronic adenoiditis, is related to adenoid hypertrophy and adenoid cystic carcinoma. An important gene associated with Adenoiditis is FCN2 (Ficolin 2), and among its related pathways/superpathways is Defensins. The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and breast.

Wikipedia : 74 Adenoiditis is the inflammation of the adenoid tissue it's usually caused by an infection. Adenoiditis... more...

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Related Diseases for Adenoiditis

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Diseases related to Adenoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 546)
# Related Disease Score Top Affiliating Genes
1 adenoid hypertrophy 12.8
2 adenoid cystic carcinoma 12.8
3 cervical adenoid cystic carcinoma 12.6
4 maxillary sinus adenoid cystic carcinoma 12.4
5 trachea adenoid cystic carcinoma 12.4
6 lacrimal gland adenoid cystic carcinoma 12.4
7 prostate adenoid cystic carcinoma 12.4
8 laryngeal adenoid cystic carcinoma 12.4
9 breast adenoid cystic carcinoma 12.4
10 lung adenoid cystic carcinoma 12.4
11 adenoid basal cell carcinoma 12.3
12 parotid gland adenoid cystic carcinoma 12.3
13 esophageal adenoid cystic carcinoma 12.3
14 cervical adenoid basal carcinoma 12.3
15 bartholin's gland adenoid cystic carcinoma 12.3
16 adenoid basal carcinoma of the cervix uteri 12.3
17 adenoid squamous cell carcinoma 12.3
18 ethmoid sinus adenoid cystic carcinoma 12.2
19 lymph node adenoid cystic carcinoma 12.1
20 obsolete: adenoid cystic carcinoma of the corpus uteri 12.1
21 sublingual gland adenoid cystic carcinoma 12.1
22 trichoepithelioma, multiple familial, 1 12.0
23 tonsillitis 12.0
24 paranasal sinus cancer 11.8
25 sleep apnea 11.6
26 prostate cancer 11.5
27 calcifying epithelial odontogenic tumor 11.5
28 cutaneous adenocystic carcinoma 11.4
29 multiple familial trichoepithelioma 11.3
30 prostate cancer, hereditary, 1 11.2
31 hurler syndrome 11.2
32 hurler-scheie syndrome 11.2
33 prostate cancer, hereditary, 12 11.2
34 prostate cancer, hereditary, 13 11.2
35 prostate cancer, hereditary, 11 11.2
36 prostate cancer, hereditary, 2 11.2
37 plague 11.2
38 ceruminous adenocarcinoma 11.2
39 otitis media 10.9
40 rare tumor 10.7
41 adenoma 10.7
42 pleomorphic adenoma 10.6
43 rhinitis 10.6
44 adenocarcinoma 10.6
45 squamous cell carcinoma 10.6
46 haemophilus influenzae 10.6
47 allergic rhinitis 10.5
48 basal cell carcinoma 10.5
49 polymorphous low-grade adenocarcinoma 10.5
50 mucoepidermoid carcinoma 10.4

Graphical network of the top 20 diseases related to Adenoiditis:



Diseases related to Adenoiditis
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Symptoms & Phenotypes for Adenoiditis

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Drugs & Therapeutics for Adenoiditis

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Drugs for Adenoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Correlation Between Adenoid Hypertrophy and Body Temperature in Children Before and After Adenoidectomy Unknown status NCT02965183
2 Does the Technique of Adenoidectomy Influence the Results of the Surgery? A Prospective Randomized Single Blind Study Completed NCT03760341
3 Analysis of Clinical, Pathologic and Molecular Markers of Adenotonsillar Hypertrophic Disease Completed NCT03541434
4 Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children Recruiting NCT03336671
5 A Prospective, Randomized, Double-blinded, Controlled Study to Evaluate Use of the PEAK PlasmaBlade TnA in Subcapsular Tonsillectomy Terminated NCT01193556

Search NIH Clinical Center for Adenoiditis

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Genetic Tests for Adenoiditis

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Anatomical Context for Adenoiditis

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MalaCards organs/tissues related to Adenoiditis:

40
Lung, Prostate, Breast, Tonsil, Thyroid, Cervix, Bone
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Publications for Adenoiditis

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Articles related to Adenoiditis:

(show top 50) (show all 168)
# Title Authors PMID Year
1
Comparison Between Radiological Versus Endoscopic Assessment of Adenoid Tissue in Patients of Chronic Adenoiditis. 61
31742106 2019
2
Adenoidal Disease and Chronic Rhinosinusitis in Children-Is there a Link? 61
31548504 2019
3
Can Symptoms Differentiate Between Chronic Adenoiditis and Chronic Rhinosinusitis in Pediatric Patients. 61
30939913 2019
4
Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review. 61
30616011 2019
5
Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease. 61
31086039 2019
6
An overview on upper respiratory tract infections and bacteriotherapy as innovative therapeutic strategy. 61
30920638 2019
7
The efficacy and tolerability of Streptococcus salivarius 24SMB and Streptococcus oralis 89a administered as nasal spray in the treatment of recurrent upper respiratory tract infections in children. 61
30920629 2019
8
Biofilm Formations in Pediatric Respiratory Tract Infection : Part 1: Biofilm Structure, Role of Innate Immunity in Protection Against and Response to Biofilm, Methods of Biofilm Detection, Pediatric Respiratory Tract Diseases Associated with Mucosal Biofilm Formation. 61
30820766 2019
9
Wet Cough and Nasal Symptoms in Children: Can We Do Better? 61
31956642 2019
10
[Tactics of conservative treatment of chronic adenoiditis in children]. 61
31198213 2019
11
[Possibility of treatment chronic adenoiditis and otitis media with effusion in children, into account the role of the microbiota of the mucous of the nasopharynx]. 61
32027332 2019
12
[Fungal adenoiditis and tonsillomycosis in children: features of diagnosis and therapy]. 61
31198221 2019
13
"Commentary to: 'Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease'"? 61
28474190 2018
14
In reply to "Commentary to: Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease", by Zhengcai Lou. 61
29423745 2018
15
[Possibilities of treatment of inflammatory pathology of the nasopharynx in children with chronic adenoiditis and otitis media with effusion]. 61
30721181 2018
16
Phenotype Profiling and Allergy in Otitis-Prone Children. 61
30564563 2018
17
Algorithm of adenoiditis treatment in adults, depending on the pharyngeal tonsil hypertrophy stage. 61
29783226 2018
18
Immune thrombocytopenia of childhood responsive to tonsillectomy in the setting of chronic tonsillitis: A case report and literature review. 61
28648251 2017
19
Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease. 61
27695944 2017
20
Inhaled Antibiotic Therapy for the Treatment of Upper Respiratory Tract Infections. 61
27336220 2017
21
Topical administration of hyaluronic acid in children with recurrent or chronic middle ear inflammations. 61
27481884 2016
22
FCN2 c.772G>T polymorphism is associated with chronic adenoiditis and/or tonsillitis, but not -4 A>G and -602 G>A. 61
27368434 2016
23
Paediatric nasopharyngeal cytology: a new diagnostic opportunity? 61
27039342 2016
24
Endoscopic Adenoidectomy in Children With Otitis Media With Effusion and Mild Hearing Loss. 61
26976024 2016
25
Clinical Practice Guideline: Otitis Media with Effusion (Update). 61
26832942 2016
26
Nasal nitric oxide in children with recurrent acute otitis media. 61
27049104 2016
27
Nonencapsulated Streptococcus pneumoniae as a cause of chronic adenoiditis. 61
27144125 2016
28
[Monitoring of microflora localized at the pharyngeal tonsil surface in the children residing in the city of Chelyabinsk and presenting with chronic adenoiditis]. 61
26977565 2016
29
[ADRENERGIC AND CHOLINERGIC INNERVATION OF THE PHARYNGEAL TONSILS IN CHILDREN WITH CHRONIC ADENOIDITIS]. 61
30136789 2016
30
[The possibilities for the rational pharmacotherapy of adenoiditis in the children]. 61
27876743 2016
31
Possible role of apoptosis in pathogenesis of adenoid hypertrophy and chronic adenoiditis: Prospective case-control study. 61
26003878 2015
32
[Clinical, significance of the nomenclature for nasal septum tail: A preliminary study]. 61
26685402 2015
33
Nasopharyngeal and Adenoid Colonization by Haemophilus influenzae and Haemophilus parainfluenzae in Children Undergoing Adenoidectomy and the Ability of Bacterial Isolates to Biofilm Production. 61
25950686 2015
34
[The analysis of the influence of the adenoiditis treatment by different methods on the nasopharyngeal microbiocenosis in the children]. 61
26525324 2015
35
[Prophylaxis of chronic adenoiditis in the children]. 61
26978751 2015
36
Clinical consensus statement: pediatric chronic rhinosinusitis. 61
25274375 2014
37
Utility of antimicrobial susceptibility testing of multiple Haemophilus influenzae isolates from throat swabs of children with adenoid hypertrophy. 61
24815933 2014
38
Prevalence of microorganisms and immunoglobulins in children with tonsillar hypertrophy and adenoiditis. 61
25992111 2014
39
Acquired absolute vitamin K deficiency in a patient undergoing warfarin therapy. 61
24439543 2014
40
Safety of adult tonsillectomy: a population-level analysis of 5968 patients. 61
24481159 2014
41
[The influence of local and combined acute suppurative Highmore maxillary sinusitis on the serum lactoferrin and interleukin-8 levels in the children]. 61
25588485 2014
42
Molar incisor hypomineralization, prevalence, and etiology. 61
24949012 2014
43
Can computed tomography score predict outcome of adenoidectomy for chronic rhinosinusitis in children. 61
24717893 2014
44
[The comparative effectiveness of framycetin included in combined therapy of adenoiditis in the children]. 61
25588492 2014
45
[Effectiveness of a herbal preparation tonsilgon N for the treatment of children presenting with chronic adenoiditis]. 61
24781178 2014
46
[The experimentally-based rationale for the application of the new methods designed to treat fungal adenoiditis in the children]. 61
25377679 2014
47
[The morphofunctional prerequisites for the development of exudative otitis media in the children presenting with chronic adenoiditis]. 61
25377676 2014
48
[The possibilities for the treatment of exudative otitis media in the children presenting with chronic adenoiditis]. 61
25734311 2014
49
C-type lectin receptors mRNA expression in patients with otitis media with effusion. 61
24094722 2013
50
The presentation and clinical significance of sinonasal respiratory epithelial adenomatoid hamartoma (REAH). 61
23038055 2013
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Variations for Adenoiditis

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ClinVar genetic disease variations for Adenoiditis:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NOTCH1 NM_017617.5(NOTCH1):c.2458C>T (p.Pro820Ser)SNV Uncertain significance 560621 rs1379596542 9:139407482-139407482 9:136513030-136513030
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Expression for Adenoiditis

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Search GEO for disease gene expression data for Adenoiditis.
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Pathways for Adenoiditis

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Pathways related to Adenoiditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Defensins 65
Show member pathways
 11.13 BPIFB6 BPIFB4 BPIFA1
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GO Terms for Adenoiditis

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Cellular components related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.28 TREM1 SSC5D NOTCH1 FCN2 BPIFB6 BPIFB4

Biological processes related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.33 SSC5D FCN2 CARD9
2 defense response to Gram-negative bacterium GO:0050829 9.32 SSC5D FCN2
3 humoral immune response GO:0006959 9.26 TREM1 NOTCH1
4 innate immune response GO:0045087 9.1 TREM1 SSC5D FCN2 CARD9 BPIFB3 BPIFA1
5 response to muramyl dipeptide GO:0032495 8.96 NOTCH1 CARD9

Molecular functions related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.13 TREM1 NOTCH1 LY75
2 lipid binding GO:0008289 9.02 BPIFB6 BPIFB4 BPIFB3 BPIFA3 BPIFA1
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Sources for Adenoiditis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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