Adenoiditis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ADN002 MIFTS: 41	Adenoiditis Categories: Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Adenoiditis

MalaCards integrated aliases for Adenoiditis:

Name: Adenoiditis ¹² ¹⁵ ⁷²

Chronic Adenoiditis ¹² ⁶ ⁷²

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050145

ICD9CM ³⁵ 474.01

ICD10 ³³ J35.02

UMLS ⁷² C0001427 C0396023

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Summaries for Adenoiditis

Disease Ontology : ¹² An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.

MalaCards based summary : Adenoiditis, also known as chronic adenoiditis, is related to lymphoma, non-hodgkin, familial and adenoid hypertrophy. An important gene associated with Adenoiditis is FCN2 (Ficolin 2), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include tonsil, colon and testes, and related phenotypes are no effect and Decreased viability in HMC1.1 cells

Wikipedia : ⁷⁵ Adenoiditis is the inflammation of the adenoid tissue it's usually caused by an infection. Adenoiditis... more...

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Related Diseases for Adenoiditis

Diseases related to Adenoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 552)

#	Related Disease	Score	Top Affiliating Genes
1	lymphoma, non-hodgkin, familial	29.3	SYK NOTCH1 MALT1 BCL10
2	adenoid hypertrophy	12.8
3	adenoid cystic carcinoma	12.8
4	cervical adenoid cystic carcinoma	12.6
5	maxillary sinus adenoid cystic carcinoma	12.4
6	trachea adenoid cystic carcinoma	12.4
7	lacrimal gland adenoid cystic carcinoma	12.4
8	prostate adenoid cystic carcinoma	12.4
9	breast adenoid cystic carcinoma	12.4
10	lung adenoid cystic carcinoma	12.4
11	laryngeal adenoid cystic carcinoma	12.3
12	adenoid basal cell carcinoma	12.3
13	cervical adenoid basal carcinoma	12.3
14	parotid gland adenoid cystic carcinoma	12.3
15	esophageal adenoid cystic carcinoma	12.3
16	adenoid basal carcinoma of the cervix uteri	12.3
17	bartholin's gland adenoid cystic carcinoma	12.3
18	adenoid squamous cell carcinoma	12.3
19	ethmoid sinus adenoid cystic carcinoma	12.2
20	lymph node adenoid cystic carcinoma	12.1
21	adenoid cystic carcinoma of the corpus uteri	12.1
22	sublingual gland adenoid cystic carcinoma	12.1
23	trichoepithelioma, multiple familial, 1	12.0
24	tonsillitis	12.0
25	paranasal sinus cancer	11.8
26	sleep apnea	11.6
27	prostate cancer	11.5
28	calcifying epithelial odontogenic tumor	11.5
29	cutaneous adenocystic carcinoma	11.4
30	multiple familial trichoepithelioma	11.3
31	prostate cancer, hereditary, 1	11.2
32	hurler syndrome	11.2
33	hurler-scheie syndrome	11.2
34	prostate cancer, hereditary, 12	11.2
35	prostate cancer, hereditary, 13	11.2
36	prostate cancer, hereditary, 11	11.2
37	prostate cancer, hereditary, 2	11.2
38	plague	11.2
39	ceruminous adenocarcinoma	11.2
40	otitis media	10.9
41	rare tumor	10.7
42	adenoma	10.7
43	pleomorphic adenoma	10.6
44	squamous cell carcinoma	10.6
45	rhinitis	10.6
46	adenocarcinoma	10.6
47	haemophilus influenzae	10.6
48	allergic rhinitis	10.5
49	basal cell carcinoma	10.5
50	polymorphous low-grade adenocarcinoma	10.5

Graphical network of the top 20 diseases related to Adenoiditis:

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Symptoms & Phenotypes for Adenoiditis

GenomeRNAi Phenotypes related to Adenoiditis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	9.92	BCL10 CARD9 CD209 CD68 CD69 CLEC7A
2	Decreased viability in HMC1.1 cells	GR00105-A-0	8.96	ITK SRC

MGI Mouse Phenotypes related to Adenoiditis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.19	BCL10 CARD9 CD68 CD69 CLEC7A CNOT4
2	cellular	MP:0005384	10.11	BCL10 CD69 FKBP4 GNAS HAVCR2 ITK
3	immune system	MP:0005387	10.09	BCL10 CARD9 CD68 CD69 CLEC7A CNOT4
4	endocrine/exocrine gland	MP:0005379	9.97	BCL10 FKBP4 GNAS ITK NOTCH1 SRC
5	mortality/aging	MP:0010768	9.73	BCL10 CLEC7A CNOT4 FKBP4 GNAS HAVCR2
6	skeleton	MP:0005390	9.23	CD68 CD69 CNOT4 GNAS NOTCH1 SRC

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Drugs & Therapeutics for Adenoiditis

Drugs for Adenoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Anesthetics

Interventional clinical trials:

#	Name	Status	NCT ID
1	The Correlation Between Adenoid Hypertrophy and Body Temperature in Children Before and After Adenoidectomy	Unknown status	NCT02965183
2	Analysis of Clinical, Pathologic and Molecular Markers of Adenotonsillar Hypertrophic Disease	Completed	NCT03541434
3	Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children	Recruiting	NCT03336671
4	Does the Technique of Adenoidectomy Influence the Results of the Surgery? A Prospective Randomized Single Blind Study	Active, not recruiting	NCT03760341
5	A Prospective, Randomized, Double-blinded, Controlled Study to Evaluate Use of the PEAK PlasmaBlade TnA in Subcapsular Tonsillectomy	Terminated	NCT01193556

Search NIH Clinical Center for Adenoiditis

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Genetic Tests for Adenoiditis

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Anatomical Context for Adenoiditis

MalaCards organs/tissues related to Adenoiditis:

⁴¹

Tonsil, Colon, Testes

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Publications for Adenoiditis

Articles related to Adenoiditis:

(show top 50) (show all 164)

#	Title	Authors	PMID	Year
1	Can Symptoms Differentiate Between Chronic Adenoiditis and Chronic Rhinosinusitis in Pediatric Patients. ³⁸	Purnell PR...Ramadan HH	30939913	2019
2	Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review. ³⁸	Wilcox CR...Little P	30616011	2019
3	Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease. ³⁸	Torretta S...Pignataro L	31086039	2019
4	An overview on upper respiratory tract infections and bacteriotherapy as innovative therapeutic strategy. ³⁸	Bellussi LM...Passali D	30920638	2019
5	The efficacy and tolerability of Streptococcus salivarius 24SMB and Streptococcus oralis 89a administered as nasal spray in the treatment of recurrent upper respiratory tract infections in children. ³⁸	Passali D...Bellussi LM	30920629	2019
6	Biofilm Formations in Pediatric Respiratory Tract Infection : Part 1: Biofilm Structure, Role of Innate Immunity in Protection Against and Response to Biofilm, Methods of Biofilm Detection, Pediatric Respiratory Tract Diseases Associated with Mucosal Biofilm Formation. ³⁸	Hamilos DL	30820766	2019
7	[Tactics of conservative treatment of chronic adenoiditis in children]. ³⁸	Maltseva GS...Bezshapochny SB	31198213	2019
8	[Fungal adenoiditis and tonsillomycosis in children: features of diagnosis and therapy]. ³⁸	Kriukov AI...Machulin AI	31198221	2019
9	"Commentary to: 'Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease'"? ³⁸	Lou Z	28474190	2018
10	In reply to "Commentary to: Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease", by Zhengcai Lou. ³⁸	Torretta S...Pignataro L	29423745	2018
11	[Possibilities of treatment of inflammatory pathology of the nasopharynx in children with chronic adenoiditis and otitis media with effusion]. ³⁸	Karpova EP...Burlakova KY	30721181	2018
12	Phenotype Profiling and Allergy in Otitis-Prone Children. ³⁸	Torretta S...Marchisio P	30564563	2018
13	Algorithm of adenoiditis treatment in adults, depending on the pharyngeal tonsil hypertrophy stage. ³⁸	Smiianov YV...Smiianova OI	29783226	2018
14	Immune thrombocytopenia of childhood responsive to tonsillectomy in the setting of chronic tonsillitis: A case report and literature review. ³⁸	Thompson RW...Gungor A	28648251	2017
15	Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease. ³⁸	Torretta S...Pignataro L	27695944	2017
16	Inhaled Antibiotic Therapy for the Treatment of Upper Respiratory Tract Infections. ³⁸	Esposito S...Principi N	27336220	2017
17	Topical administration of hyaluronic acid in children with recurrent or chronic middle ear inflammations. ³⁸	Torretta S...Pignataro L	27481884	2016
18	FCN2 c.772G>T polymorphism is associated with chronic adenoiditis and/or tonsillitis, but not -4 A>G and -602 G>A. ³⁸	Erkan AN...Sahin FI	27368434	2016
19	Paediatric nasopharyngeal cytology: a new diagnostic opportunity? ³⁸	Torretta S...Pignataro L	27039342	2016
20	Endoscopic Adenoidectomy in Children With Otitis Media With Effusion and Mild Hearing Loss. ³⁸	Capaccio P...Pignataro L	26976024	2016
21	Clinical Practice Guideline: Otitis Media with Effusion (Update). ³⁸	Rosenfeld RM...Corrigan MD	26832942	2016
22	Nasal nitric oxide in children with recurrent acute otitis media. ³⁸	Torretta S...Pignataro L	27049104	2016
23	Nonencapsulated Streptococcus pneumoniae as a cause of chronic adenoiditis. ³⁸	Dixit C...McDaniel LS	27144125	2016
24	[Monitoring of microflora localized at the pharyngeal tonsil surface in the children residing in the city of Chelyabinsk and presenting with chronic adenoiditis]. ³⁸	Gizinger OA...Shchetinin SA	26977565	2016
25	[ADRENERGIC AND CHOLINERGIC INNERVATION OF THE PHARYNGEAL TONSILS IN CHILDREN WITH CHRONIC ADENOIDITIS]. ³⁸	Shustova TI...Samotokin MB	30136789	2016
26	[The possibilities for the rational pharmacotherapy of adenoiditis in the children]. ³⁸	Karpova EP...Kharina DV	27876743	2016
27	Possible role of apoptosis in pathogenesis of adenoid hypertrophy and chronic adenoiditis: Prospective case-control study. ³⁸	Onal M...Bajin MD	26003878	2015
28	[Clinical, significance of the nomenclature for nasal septum tail: A preliminary study]. ³⁸	Zhang Q...Song W	26685402	2015
29	Nasopharyngeal and Adenoid Colonization by Haemophilus influenzae and Haemophilus parainfluenzae in Children Undergoing Adenoidectomy and the Ability of Bacterial Isolates to Biofilm Production. ³⁸	Kosikowska U...Malm A	25950686	2015
30	[The analysis of the influence of the adenoiditis treatment by different methods on the nasopharyngeal microbiocenosis in the children]. ³⁸	Nesterova KI...Nesterova AA	26525324	2015
31	[Prophylaxis of chronic adenoiditis in the children]. ³⁸	Karpova EP...Tulupov DA	26978751	2015
32	Clinical consensus statement: pediatric chronic rhinosinusitis. ³⁸	Brietzke SE...Rosenfeld RM	25274375	2014
33	Utility of antimicrobial susceptibility testing of multiple Haemophilus influenzae isolates from throat swabs of children with adenoid hypertrophy. ³⁸	Antos-Bielska M...Trafny EA	24815933	2014
34	Prevalence of microorganisms and immunoglobulins in children with tonsillar hypertrophy and adenoiditis. ³⁸	Miramontes HP...Souza MR	25992111	2014
35	Acquired absolute vitamin K deficiency in a patient undergoing warfarin therapy. ³⁸	Takada H...Yasuhiro K	24439543	2014
36	Safety of adult tonsillectomy: a population-level analysis of 5968 patients. ³⁸	Chen MM...Judson BL	24481159	2014
37	Can computed tomography score predict outcome of adenoidectomy for chronic rhinosinusitis in children. ³⁸	Ramadan HH...Makary CA	24717893	2014
38	[The influence of local and combined acute suppurative Highmore maxillary sinusitis on the serum lactoferrin and interleukin-8 levels in the children]. ³⁸	Klimova II...Zorin NA	25588485	2014
39	Molar incisor hypomineralization, prevalence, and etiology. ³⁸	Allazzam SM...El Meligy OA	24949012	2014
40	[The comparative effectiveness of framycetin included in combined therapy of adenoiditis in the children]. ³⁸	Soldatskii IuL...Ivanenko AM	25588492	2014
41	[The experimentally-based rationale for the application of the new methods designed to treat fungal adenoiditis in the children]. ³⁸	Kriukov AI...Shadrin GB	25377679	2014
42	[Effectiveness of a herbal preparation tonsilgon N for the treatment of children presenting with chronic adenoiditis]. ³⁸	Klimova II...Bazhenov DV	24781178	2014
43	[The morphofunctional prerequisites for the development of exudative otitis media in the children presenting with chronic adenoiditis]. ³⁸	Pleshko RI...Fedorova OV	25377676	2014
44	[The possibilities for the treatment of exudative otitis media in the children presenting with chronic adenoiditis]. ³⁸	Karpova EP...Tulupov DA	25734311	2014
45	C-type lectin receptors mRNA expression in patients with otitis media with effusion. ³⁸	Lee JH...Yeo SG	24094722	2013
46	The presentation and clinical significance of sinonasal respiratory epithelial adenomatoid hamartoma (REAH). ³⁸	Hawley KA...Sindwani R	23038055	2013
47	Topographic distribution of biofilm-producing bacteria in adenoid subsites of children with chronic or recurrent middle ear infections. ³⁸	Torretta S...Pignataro L	23534125	2013
48	Adenoid ciliostimulation in children with chronic otitis media. ³⁸	Andreoli SM...White DR	23032917	2013
49	[Laryngopharyngeal reflux as a possible cause of adenoiditis in adult patients]. ³⁸	Angotoeva IB...Muldasheva AA	23887376	2013
50	[The effectiveness of rinorin introduced in the combined treatment of chronic adenoiditis in the children]. ³⁸	Soldatskii IuL...Popova SN	23715494	2013

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Genes for Adenoiditis

Genes related to Adenoiditis (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FCN2	Ficolin 2	Protein Coding	21.48	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	NOTCH1	Notch Receptor 1	Protein Coding	18.13	GeneCards inferred via : Variants (show sections)
3	CNOT4	CCR4-NOT Transcription Complex Subunit 4	Protein Coding	15.5	DISEASES inferred ¹⁵
4	LY75	Lymphocyte Antigen 75	Protein Coding	15.19	DISEASES inferred ¹⁵
5	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	15.15	DISEASES inferred ¹⁵
6	TYROBP	TYRO Protein Tyrosine Kinase Binding Protein	Protein Coding	15.01	DISEASES inferred ¹⁵
7	CLEC7A	C-Type Lectin Domain Containing 7A	Protein Coding	14.85	DISEASES inferred ¹⁵
8	TREM1	Triggering Receptor Expressed On Myeloid Cells 1	Protein Coding	14.8	DISEASES inferred ¹⁵
9	ITK	IL2 Inducible T Cell Kinase	Protein Coding	14.73	DISEASES inferred ¹⁵
10	CD209	CD209 Molecule	Protein Coding	14.67	DISEASES inferred ¹⁵
11	MALT1	MALT1 Paracaspase	Protein Coding	14.58	DISEASES inferred ¹⁵
12	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	14.56	DISEASES inferred ¹⁵
13	TSPO	Translocator Protein	Protein Coding	14.38	DISEASES inferred ¹⁵
14	HAVCR2	Hepatitis A Virus Cellular Receptor 2	Protein Coding	14.34	DISEASES inferred ¹⁵
15	GNAS	GNAS Complex Locus	Protein Coding	14.09	DISEASES inferred ¹⁵
16	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	13.96	DISEASES inferred ¹⁵
17	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	13.06	DISEASES inferred ¹⁵
18	CD69	CD69 Molecule	Protein Coding	4.01	DISEASES inferred ¹⁵
19	FKBP4	FKBP Prolyl Isomerase 4	Protein Coding	3.26	DISEASES inferred ¹⁵
20	CD68	CD68 Molecule	Protein Coding	3.23	DISEASES inferred ¹⁵

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Variations for Adenoiditis

ClinVar genetic disease variations for Adenoiditis:

⁶

#	Gene	Variation	Type	Significance	SNP ID	GRCh37 Pos	GRCh38 Pos
1	NOTCH1	NM_017617.5(NOTCH1): c.2458C> T (p.Pro820Ser)	single nucleotide variant	Uncertain significance		9:139407482-139407482	9:136513030-136513030

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Expression for Adenoiditis

Search GEO for disease gene expression data for Adenoiditis.

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Pathways for Adenoiditis

Pathways related to Adenoiditis according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.73	TYROBP TREM1 SYK SRC MALT1 ITK
2	Class I MHC mediated antigen processing and presentation ⁶⁶ Show member pathways Adaptive Immune System ⁶⁶ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁶	13.21	TYROBP TREM1 SYK SRC MALT1 ITK
3	IL-2 Pathway ⁶⁴ Show member pathways ErbB Family Pathway ⁶⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-4 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ Prolactin Signaling ⁶⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	12.99	TYROBP TREM1 SYK SRC MALT1 GNAS
4	TCR Signaling (Qiagen) ⁶⁴ Show member pathways Fc-EpsilonRI Pathway ⁶⁴ ITK and TCR Signaling ⁶⁴ PDGF Pathway ⁶⁴ PKC-Theta Pathway ⁶⁴	12.72	SYK SRC MALT1 ITK BCL10
5	NF-kappaB Signaling ⁴	12.32	TYROBP SYK MALT1 ITK HAVCR2 CARD9
6	ICos-ICosL Pathway in T-Helper Cell ⁶⁴ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁴ CD28 Signaling in T-Helper Cell ⁶⁴	12.16	SYK MALT1 ITK BCL10
7	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	12.11	SYK SRC MALT1 CLEC7A CD209 CARD9
8	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²² Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²²	11.98	TYROBP TREM1 SYK SRC ITK GNAS
9	Platelet activation ³⁷	11.83	SYK SRC GNAS
10	Tuberculosis ³⁷	11.75	SYK SRC MALT1 CLEC7A CD209 CARD9
11	TCR signaling in naive CD4+ T cells ¹ Show member pathways TCR signaling in naive CD8+ T cells ¹	11.73	MALT1 ITK BCL10
12	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.73	NOTCH1 CD69 CD68 CD209
13	NF-kappa B signaling pathway ³⁷	11.68	SYK MALT1 BCL10
14	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	11.41	SYK SRC MALT1 CLEC7A CD209 CARD9
15	Amplification and Expansion of Oncogenic Pathways as Metastatic Traits ¹	10.77	SRC NOTCH1
16	Atypical NF-kappaB pathway ¹	10.66	SYK SRC

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GO Terms for Adenoiditis

Cellular components related to Adenoiditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein-containing complex	GO:0032991	9.55	SYK MALT1 FKBP4 CD69 BCL10
2	cell surface	GO:0009986	9.35	TYROBP NOTCH1 HAVCR2 CD69 CD209
3	CBM complex	GO:0032449	8.62	MALT1 BCL10

Biological processes related to Adenoiditis according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	response to drug	GO:0042493	9.88	TSPO SRC GNAS CARD9
2	intracellular signal transduction	GO:0035556	9.85	TYROBP TREM1 SYK SRC ITK CD209
3	adaptive immune response	GO:0002250	9.83	SYK ITK HAVCR2 CD209 BCL10
4	immune system process	GO:0002376	9.81	SYK SRC ITK HAVCR2 FCN2 CLEC7A
5	T cell receptor signaling pathway	GO:0050852	9.76	MALT1 ITK BCL10
6	defense response to Gram-positive bacterium	GO:0050830	9.73	HAVCR2 FCN2 CARD9
7	integrin-mediated signaling pathway	GO:0007229	9.72	TYROBP SYK SRC
8	Fc-epsilon receptor signaling pathway	GO:0038095	9.71	SYK MALT1 ITK BCL10
9	cellular defense response	GO:0006968	9.67	TYROBP ITK BCL10
10	positive regulation of interleukin-4 production	GO:0032753	9.59	SYK HAVCR2
11	negative regulation of anoikis	GO:2000811	9.57	SRC NOTCH1
12	response to muramyl dipeptide	GO:0032495	9.54	NOTCH1 CARD9
13	response to molecule of bacterial origin	GO:0002237	9.52	MALT1 BCL10
14	negative regulation of glial cell proliferation	GO:0060253	9.51	TSPO NOTCH1
15	macrophage activation involved in immune response	GO:0002281	9.5	TYROBP SYK HAVCR2
16	regulation of T cell receptor signaling pathway	GO:0050856	9.48	MALT1 BCL10
17	neutrophil activation involved in immune response	GO:0002283	9.46	TYROBP SYK
18	response to fungus	GO:0009620	9.43	MALT1 CARD9 BCL10
19	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.43	SYK SRC MALT1 CD209 CARD9 BCL10
20	innate immune response	GO:0045087	9.32	TYROBP TREM1 SYK MALT1 HAVCR2 FCN2

Molecular functions related to Adenoiditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	CARD domain binding	GO:0050700	9.32	CARD9 BCL10
2	kinase activator activity	GO:0019209	9.16	MALT1 BCL10
3	non-membrane spanning protein tyrosine kinase activity	GO:0004715	9.13	SYK SRC ITK
4	carbohydrate binding	GO:0030246	9.02	LY75 FCN2 CLEC7A CD69 CD209
5	protein binding	GO:0005515	10.19	TYROBP TSPO SYK SRC NOTCH1 MALT1

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Sources for Adenoiditis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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¹⁰ dbSNP

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¹⁶ DrugBank

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁴ MeSH

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⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia