MCID: ADN002
MIFTS: 34

Adenoiditis

Categories: Respiratory diseases

Aliases & Classifications for Adenoiditis

MalaCards integrated aliases for Adenoiditis:

Name: Adenoiditis 12 15 74
Chronic Adenoiditis 12 6 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050145
ICD9CM 36 474.01
ICD10 34 J35.02

Summaries for Adenoiditis

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.

MalaCards based summary : Adenoiditis, also known as chronic adenoiditis, is related to adenoid cystic carcinoma and adenoid hypertrophy. An important gene associated with Adenoiditis is FCN2 (Ficolin 2). The drugs Mannitol and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include prostate, lung and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Adenoiditis is the inflammation of the adenoid tissue it''s usually caused by an infection. Adenoiditis... more...

Related Diseases for Adenoiditis

Diseases related to Adenoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 12.7
2 adenoid hypertrophy 12.7
3 cervical adenoid cystic carcinoma 12.5
4 maxillary sinus adenoid cystic carcinoma 12.3
5 lacrimal gland adenoid cystic carcinoma 12.3
6 trachea adenoid cystic carcinoma 12.3
7 prostate adenoid cystic carcinoma 12.3
8 breast adenoid cystic carcinoma 12.3
9 lung adenoid cystic carcinoma 12.2
10 adenoid basal cell carcinoma 12.2
11 laryngeal adenoid cystic carcinoma 12.2
12 esophageal adenoid cystic carcinoma 12.2
13 parotid gland adenoid cystic carcinoma 12.2
14 bartholin's gland adenoid cystic carcinoma 12.2
15 adenoid squamous cell carcinoma 12.2
16 ethmoid sinus adenoid cystic carcinoma 12.1
17 cervical adenoid basal carcinoma 12.1
18 adenoid basal carcinoma of the cervix uteri 12.1
19 lymph node adenoid cystic carcinoma 12.0
20 adenoid cystic carcinoma of the corpus uteri 12.0
21 sublingual gland adenoid cystic carcinoma 12.0
22 trichoepithelioma, multiple familial, 1 11.9
23 tonsillitis 11.8
24 cutaneous adenocystic carcinoma 11.6
25 sleep apnea 11.4
26 paranasal sinus cancer 11.3
27 multiple familial trichoepithelioma 11.1
28 prostate cancer 11.0
29 prostate cancer, hereditary, 1 11.0
30 hurler syndrome 11.0
31 hurler-scheie syndrome 11.0
32 prostate cancer, hereditary, 12 11.0
33 prostate cancer, hereditary, 13 11.0
34 prostate cancer, hereditary, 11 11.0
35 prostate cancer, hereditary, 2 11.0
36 plague 11.0
37 ceruminous adenocarcinoma 11.0
38 calcifying epithelial odontogenic tumor 11.0
39 muscle hypertrophy 10.6
40 otitis media 10.6
41 adenoma 10.5
42 squamous cell carcinoma 10.5
43 adenocarcinoma 10.5
44 pleomorphic adenoma 10.5
45 polymorphous low-grade adenocarcinoma 10.4
46 basal cell carcinoma 1 10.4
47 basal cell carcinoma 10.4
48 aplasia cutis congenita, nonsyndromic 10.3
49 rhinitis 10.3
50 allergic rhinitis 10.3

Graphical network of the top 20 diseases related to Adenoiditis:



Diseases related to Adenoiditis

Symptoms & Phenotypes for Adenoiditis

GenomeRNAi Phenotypes related to Adenoiditis according to GeneCards Suite gene sharing:

27 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.7 LY75
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.7 TYROBP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.7 LY75
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.7 LY75
5 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.7 CARD9
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.7 CARD9
7 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.7 TYROBP LY75
8 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.7 CARD9
9 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.7 LY75
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.7 LY75
11 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.7 CARD9
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 CARD9
13 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.7 CARD9 TYROBP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.7 CARD9
15 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.7 CARD9
16 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.7 TYROBP
17 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.7 LY75
18 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.7 LY75
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.26 CARD9
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.26 CARD9 CNOT4
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.26 CNOT4

MGI Mouse Phenotypes related to Adenoiditis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.26 CARD9 CNOT4 LY75 TYROBP
2 immune system MP:0005387 8.92 CARD9 CNOT4 LY75 TYROBP

Drugs & Therapeutics for Adenoiditis

Drugs for Adenoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
3
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
4
Propyl Gallate Investigational Phase 4 121-79-9 4947
5 Broncho-Vaxom Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Pharmaceutical Solutions Phase 4
8 Analgesics Phase 4
9 Adrenergic alpha-Agonists Phase 4
10 Adrenergic Agents Phase 4
11 Adrenergic alpha-2 Receptor Agonists Phase 4
12 Adrenergic Agonists Phase 4
13 Peripheral Nervous System Agents Phase 4
14 Hypnotics and Sedatives Phase 4
15 Neurotransmitter Agents Phase 4
16 Central Nervous System Depressants Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy Not yet recruiting NCT03243565 Phase 4
2 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Terminated NCT02162433 Phase 4 Normal Saline;Dexmedetomidine

Search NIH Clinical Center for Adenoiditis

Genetic Tests for Adenoiditis

Anatomical Context for Adenoiditis

MalaCards organs/tissues related to Adenoiditis:

42
Prostate, Lung, Breast, Tonsil, Pituitary, Thyroid, Cervix

Publications for Adenoiditis

Articles related to Adenoiditis:

(show all 28)
# Title Authors Year
1
Can Symptoms Differentiate Between Chronic Adenoiditis and Chronic Rhinosinusitis in Pediatric Patients. ( 30939913 )
2019
2
Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease. ( 31086039 )
2019
3
"Commentary to: 'Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease'"? ( 28474190 )
2018
4
In reply to "Commentary to: Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease", by Zhengcai Lou. ( 29423745 )
2018
5
Algorithm of adenoiditis treatment in adults, depending on the pharyngeal tonsil hypertrophy stage. ( 29783226 )
2018
6
Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease. ( 27695944 )
2017
7
Nonencapsulated Streptococcus pneumoniae as a cause of chronic adenoiditis. ( 27144125 )
2016
8
FCN2 c.772G>T polymorphism is associated with chronic adenoiditis and/or tonsillitis, but not -4 A>G and -602 G>A. ( 27368434 )
2016
9
Possible role of apoptosis in pathogenesis of adenoid hypertrophy and chronic adenoiditis: Prospective case-control study. ( 26003878 )
2015
10
Prevalence of microorganisms and immunoglobulins in children with tonsillar hypertrophy and adenoiditis. ( 25992111 )
2014
11
Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis. ( 22339566 )
2012
12
Association of adenoid hyperplasia and bacterial biofilm formation in children with adenoiditis in Taiwan. ( 21779840 )
2012
13
The utility of nasopharyngeal culture in the management of chronic adenoiditis. ( 22784508 )
2012
14
Diagnostic accuracy of nasopharyngeal swabs in detecting biofilm-producing bacteria in chronic adenoiditis: a preliminary study. ( 21493370 )
2011
15
Ribosomal therapy in the treatment of recurrent acute adenoiditis. ( 20052587 )
2010
16
Role of adenoids and adenoiditis in children with allergy and otitis media. ( 19814919 )
2009
17
Increased risk of otitis media with effusion in allergic children presenting with adenoiditis. ( 18439460 )
2008
18
Spatial organisation of microbiota in quiescent adenoiditis and tonsillitis. ( 16698947 )
2007
19
The 10-day mark is a good way to diagnose not only acute rhinosinusitis but also adenoiditis, as confirmed by endoscopy. ( 17239449 )
2007
20
Invasive fungal adenoiditis. ( 16564404 )
2006
21
Nasal endoscopy in asthmatic children: assessment of rhinosinusitis and adenoiditis incidence, correlations with cytology and microbiology. ( 11359430 )
2001
22
Sore throat, tonsillitis, and adenoiditis. ( 9927961 )
1999
23
What is wrong in chronic adenoiditis/tonsillitis anatomical considerations. ( 10577791 )
1999
24
What is wrong in chronic adenoiditis/tonsillitis immunological factor. ( 10577792 )
1999
25
Acute suppurative adenoiditis. ( 2773892 )
1989
26
Nasal obstruction. Adenoiditis vs adenoid hypertrophy. ( 7200351 )
1982
27
Suppurative adenoiditis. ( 13542062 )
1958
28
Respiratory obstruction caused by acute tonsillitis and acute adenoiditis. ( 13334825 )
1956

Variations for Adenoiditis

ClinVar genetic disease variations for Adenoiditis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NOTCH1 NM_017617.5(NOTCH1): c.2458C> T (p.Pro820Ser) single nucleotide variant Uncertain significance GRCh38 Chromosome 9, 136513030: 136513030
2 NOTCH1 NM_017617.5(NOTCH1): c.2458C> T (p.Pro820Ser) single nucleotide variant Uncertain significance GRCh37 Chromosome 9, 139407482: 139407482

Expression for Adenoiditis

Search GEO for disease gene expression data for Adenoiditis.

Pathways for Adenoiditis

GO Terms for Adenoiditis

Biological processes related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 8.96 CARD9 FCN2
2 innate immune response GO:0045087 8.8 CARD9 FCN2 TYROBP

Molecular functions related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.62 FCN2 LY75

Sources for Adenoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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