MCID: ADN075
MIFTS: 39

Adenomyoma

Categories: Cancer diseases, Endocrine diseases, Muscle diseases

Aliases & Classifications for Adenomyoma

MalaCards integrated aliases for Adenomyoma:

Name: Adenomyoma 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2609
MeSH 44 D018194
NCIt 50 C3726
SNOMED-CT 68 40293003
UMLS 73 C0206622

Summaries for Adenomyoma

Disease Ontology : 12 A carcinosarcoma that has material basis in gland and muscle components.

MalaCards based summary : Adenomyoma is related to atypical polypoid adenomyoma and adenocarcinoma. An important gene associated with Adenomyoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and O-linked glycosylation. The drugs Letrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include uterus, small intestine and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Adenomyoma is a tumor (-oma) including components derived from glands (adeno-) and muscle (-my-). It is... more...

Related Diseases for Adenomyoma

Diseases related to Adenomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 atypical polypoid adenomyoma 33.7 CTNNB1 MLH1 MME
2 adenocarcinoma 30.3 CTNNB1 MLH1 MUC1 MUC4
3 endometrial adenocarcinoma 29.7 CTNNB1 KRT7 MLH1
4 pseudomyxoma peritonei 29.5 KRT7 MUC1 MUC6
5 endometrial cancer 29.3 CTNNB1 KRT7 MLH1 MME
6 cholangiocarcinoma 29.1 CTNNB1 KRT7 MME MUC1 MUC4
7 gastric adenocarcinoma 29.0 CTNNB1 KRT7 MLH1 MUC1 MUC4
8 cervical adenomyoma 12.4
9 uterine corpus atypical polypoid adenomyoma 12.3
10 endocervical type cervical adenomyoma 12.3
11 endometrial type cervical adenomyoma 12.3
12 cervical atypical polypoid adenomyoma 12.3
13 adenomyoma of uterine corpus 12.1
14 bartholin's gland adenomyoma 12.1
15 adenomyosis 11.4
16 intussusception 10.3
17 psammomatous meningioma 10.2 CTNNB1 MME
18 adenofibroma 10.2 MME MUC1
19 pyloric stenosis 10.2
20 chronic orbital inflammation 10.2 MME MUC1
21 perivascular epithelioid cell tumor 10.2 MME MUC1
22 lobular neoplasia 10.1 CTNNB1 MUC1
23 meningeal melanocytoma 10.1 MME MUC1
24 polymorphous low-grade adenocarcinoma 10.1 CTNNB1 MUC1
25 tumor of exocrine pancreas 10.1 MUC1 MUC6
26 pancreatic intraductal papillary-mucinous neoplasm 10.1 MUC1 MUC6
27 microcystic adenoma 10.1 MUC1 MUC6
28 leiomyoma 10.1
29 adenosarcoma 10.1
30 filamentary keratitis 10.1 MUC1 MUC4
31 limbal stem cell deficiency 10.1 MUC1 MUC4
32 pilomatrixoma 10.1 CTNNB1 MUC1
33 mixed ductal-endocrine carcinoma 10.1 MUC1 MUC6
34 epstein-barr virus-associated gastric carcinoma 10.1 CTNNB1 MUC6
35 small intestine adenocarcinoma 10.1 MLH1 MUC6
36 polyposis syndrome, hereditary mixed, 1 10.1 MLH1 MUC6
37 intestinal benign neoplasm 10.0 CTNNB1 MLH1
38 balloon cell malignant melanoma 10.0 KRT7 MME
39 cervical adenoma malignum 10.0 KRT7 MME
40 cervical mucinous adenocarcinoma 10.0 KRT7 MME
41 clear cell papillary renal cell carcinoma 10.0 KRT7 MME
42 malignant leydig cell tumor 10.0 KRT7 MME
43 bladder lymphoma 10.0 KRT7 MME
44 large intestine adenocarcinoma 10.0 CTNNB1 KRT7
45 cholecystitis 10.0 MUC1 MUC6
46 lung acinar adenocarcinoma 10.0 CTNNB1 KRT7
47 kidney benign neoplasm 10.0 KRT7 MME
48 breast adenomyoepithelioma 10.0 KRT7 MME
49 breast myoepithelial neoplasm 10.0 KRT7 MME
50 papillary craniopharyngioma 10.0 CTNNB1 KRT7

Graphical network of the top 20 diseases related to Adenomyoma:



Diseases related to Adenomyoma

Symptoms & Phenotypes for Adenomyoma

GenomeRNAi Phenotypes related to Adenomyoma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.62 CTNNB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.62 CTNNB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.62 MLH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.62 MLH1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.62 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.62 MLH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.62 CTNNB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.62 KRT7
9 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.62 MLH1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.62 CTNNB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.62 CTNNB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.62 CTNNB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.62 CTNNB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.62 CTNNB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.62 CTNNB1 KRT7 MLH1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.62 MLH1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.62 CTNNB1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.62 MLH1

Drugs & Therapeutics for Adenomyoma

Drugs for Adenomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Letrozole Approved, Investigational Phase 2, Phase 3 112809-51-5 3902
2
Goserelin Approved Phase 2, Phase 3 65807-02-5 47725 5311128
3
Lactitol Investigational Phase 2, Phase 3 585-86-4 3871
4 Estrogen Antagonists Phase 2, Phase 3
5 Antineoplastic Agents, Hormonal Phase 2, Phase 3
6 Hormone Antagonists Phase 2, Phase 3
7 Aromatase Inhibitors Phase 2, Phase 3
8 Estrogen Receptor Antagonists Phase 2, Phase 3
9 Estrogens Phase 2, Phase 3
10 Steroid Synthesis Inhibitors Phase 2, Phase 3
11 Hormones Phase 2, Phase 3
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
2 Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis Completed NCT01218581 Phase 2, Phase 3 received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)

Search NIH Clinical Center for Adenomyoma

Cochrane evidence based reviews: adenomyoma

Genetic Tests for Adenomyoma

Anatomical Context for Adenomyoma

MalaCards organs/tissues related to Adenomyoma:

41
Uterus, Small Intestine, Ovary, Pancreas, Lung, Kidney, Breast

Publications for Adenomyoma

Articles related to Adenomyoma:

(show top 50) (show all 274)
# Title Authors Year
1
Hysteroscopic Transcervical Resection for Atypical Polypoid Adenomyoma of the Uterus: A Valid, Fertility-Preserving Option. ( 29038039 )
2018
2
Combination of Adenomyoma and Adenomyomatous Hyperplasia of the Ampullary System: A First Case Report. ( 29618230 )
2018
3
Maintenance hormonal therapy after treatment with medroxyprogesterone acetate for patients with atypical polypoid adenomyoma. ( 29351618 )
2018
4
A case of rapidly-growing atypical polypoid adenomyoma which was histologically diagnosed before operation and removed by a laparoscopic resection. ( 29458879 )
2018
5
Uterine adenomyosis and adenomyoma: the surgical approach. ( 29566853 )
2018
6
Postoperative maintenance levonorgestrel-releasing intrauterine system for symptomatic uterine adenomyoma. ( 29458902 )
2018
7
Management of atypical polypoid adenomyoma of the uterus: A single center's experience. ( 29561413 )
2018
8
Extrauterine adenomyoma: a review of the literature. ( 29940416 )
2018
9
Pregnant outcomes of atypical polypoid adenomyoma treated with progestin therapy. ( 29121416 )
2018
10
Endometrioid Adenocarcinoma Arising in Adenomyoma in a Woman with a Genital Prolapse - Case Report. ( 29983808 )
2018
11
SATB2 is Consistently Expressed in Squamous Morules Associated With Endometrioid Proliferative Lesions and in the Stroma of Atypical Polypoid Adenomyoma. ( 30085940 )
2018
12
Successful laparotomy tumor resection and levonorgestrel-releasing intrauterine system for atypical polypoid adenomyoma. ( 30094884 )
2018
13
MRI of prolapsed polypoid adenomyoma: Expanding the differential diagnosis for the broccoli sign. ( 30096556 )
2018
14
Recurrence-associated factors of laparoscopic adenomyomectomy for severely symptomatic adenomyoma. ( 30127945 )
2018
15
A rare case of a gastric adenomyoma mimicking a gastric duplication cyst. ( 30260786 )
2018
16
Sonographic diagnosis of an ileal adenomyoma in a neonate. ( 30549276 )
2018
17
Cytomorphological features of atypical polypoid adenomyoma of the endometrium. ( 30556192 )
2018
18
Cytological features of atypical polypoid adenomyoma of the endometrium: A case report with literature review. ( 28160434 )
2017
19
Clinicopathological Characteristics of Primary Ovarian Adenomyoma: A Single-institutional Experience. ( 28476828 )
2017
20
A Rapidly Enlarging MA1llerian-Derived Hepatic Adenomyoma Clinically Mimicking Hepatic Adenoma in a Pregnant Woman. ( 28766580 )
2017
21
Extrauterine Adenomyoma of the Liver in a 50 year old Female with Pelvic Endometriosis. ( 28442524 )
2017
22
Gastric Adenomyoma: The Unexpected Mimicker. ( 29255751 )
2017
23
Adenomyoma With Pseudoinvasive Growth Pattern and Serosal Penetration Mimicking Endometrial Carcinoma. ( 28700437 )
2017
24
Endoscopic submucosal dissection for gastric adenomyoma: A rare entity of 15 cases among 571 patients with gastric submucosal eminence lesions. ( 28248886 )
2017
25
Round Ligament Adenomyoma. ( 29269127 )
2017
26
Juvenile Cystic Adenomyoma Mimicking a Uterine Anomaly: a Report of Two Cases. ( 28416935 )
2017
27
Recurrent atypical polypoid adenomyoma and pregnancy: A new conservative approach with levonorgestrel-releasing intrauterine system. ( 28761925 )
2017
28
Endometrial adenomyoma polyp caused postmenopausal bleeding mimicking uterine malignancy. ( 30254897 )
2017
29
Parasitic Myomas and an Adenomyoma Obstructing the Ureter After Power Morcellation of Myomas and Endometriotic Nodule Resection. ( 27208606 )
2016
30
Gastric adenomyoma clinically simulating hypertrophic pyloric stenosis. ( 26837724 )
2016
31
An Unusual Case of Noninvasive Adenocarcinoma Arising in a Localized Adenomyoma of the Gallbladder and Review of Literature. ( 26721302 )
2016
32
EP27.09: Pelvic adenomyoma, eleven years after total hysterectomy: rare report and literature review. ( 27647499 )
2016
33
Adenomyoma of the common bile duct: a rare lesion diagnosed and treated by ERCP. ( 27509468 )
2016
34
Positron Emission Tomography Findings in Atypical Polypoid Adenomyoma. ( 27134711 )
2016
35
A mixed carcinoma of the uterus arising from an atypical polypoid adenomyoma: a case report. ( 29943938 )
2016
36
A novel laparoscopic surgical technique for severe adenomyoma. ( 30074314 )
2016
37
Decidualization of uterine adenomyoma in a pregnant woman: a case report with immunohistochemical study. ( 25182212 )
2015
38
Endocervical Atypical Polypoid Adenomyoma. ( 26304721 )
2015
39
Rare case of giant cystic adenomyoma mimicking a uterine malformation, diagnosed and treated by hysteroscopy. ( 25833279 )
2015
40
Long-term outcomes of fertility-sparing treatment of atypical polypoid adenomyoma with medroxyprogesterone acetate. ( 26209972 )
2015
41
Adenomyoma of the duodenum. ( 26263354 )
2015
42
MR manifestations of uterine polypoid adenomyoma. ( 25516215 )
2015
43
Laparoscopic Management of Juvenile Cystic Adenomyoma. ( 27678779 )
2015
44
A coexistence case of right tubal adenomyoma and ectopic pregnancy. ( 24879049 )
2015
45
Atypical Polypoid Adenomyoma of the Uterus: An Immunohistochemical and Molecular Study of 21 Cases. ( 25828387 )
2015
46
A case of endometrioid adenocarcinoma developing 8A years after conservative management for atypical polypoid adenomyoma. ( 24707458 )
2014
47
Polypoid adenomyoma of endocervical type. ( 25105047 )
2014
48
Large uterine cervical adenomyoma excised by vaginal approach: case report, images, and literature review. ( 24582628 )
2014
49
Coexistence of endometrioid adenocarcinoma in atypical polypoid adenomyoma. ( 25612673 )
2014
50
Magnetic Resonance Imaging Findings in Atypical Polypoid Adenomyoma. ( 25286280 )
2014

Variations for Adenomyoma

Expression for Adenomyoma

Search GEO for disease gene expression data for Adenomyoma.

Pathways for Adenomyoma

GO Terms for Adenomyoma

Cellular components related to Adenomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 CTNNB1 KRT7 MME MUC1 MUC4
2 Golgi lumen GO:0005796 8.8 MUC1 MUC4 MUC6

Biological processes related to Adenomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 maintenance of gastrointestinal epithelium GO:0030277 9.16 MUC4 MUC6
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 MUC1 MUC4 MUC6
3 O-glycan processing GO:0016266 8.8 MUC1 MUC4 MUC6

Sources for Adenomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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