MCID: ADN075
MIFTS: 36

Adenomyoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adenomyoma

MalaCards integrated aliases for Adenomyoma:

Name: Adenomyoma 12 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2609
MeSH 45 D018194
NCIt 51 C3726
SNOMED-CT 69 40293003
UMLS 74 C0206622

Summaries for Adenomyoma

Disease Ontology : 12 A carcinosarcoma that has material basis in gland and muscle components.

MalaCards based summary : Adenomyoma is related to atypical polypoid adenomyoma and adenocarcinoma. An important gene associated with Adenomyoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways is Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Letrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include uterus, small intestine and smooth muscle, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Adenomyoma is a tumor (-oma) including components derived from glands (adeno-) and muscle (-my-). It is... more...

Related Diseases for Adenomyoma

Diseases related to Adenomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 atypical polypoid adenomyoma 33.7 CTNNB1 MLH1 MME
2 adenocarcinoma 30.1 CTNNB1 MLH1 MUC1 MUC4
3 pseudomyxoma peritonei 29.8 KRT7 MUC1
4 endometrial cancer 29.6 CTNNB1 KRT7 MLH1 MME
5 endometrial adenocarcinoma 29.6 CTNNB1 KRT7 MLH1
6 cholangiocarcinoma 28.7 CTNNB1 KRT7 MME MUC1 MUC4
7 gastric adenocarcinoma 28.5 CTNNB1 KRT7 MLH1 MUC1 MUC4
8 cervical adenomyoma 12.4
9 uterine corpus atypical polypoid adenomyoma 12.3
10 endocervical type cervical adenomyoma 12.3
11 endometrial type cervical adenomyoma 12.3
12 cervical atypical polypoid adenomyoma 12.3
13 adenomyoma of uterine corpus 12.1
14 bartholin's gland adenomyoma 12.1
15 adenomyosis 11.5
16 psammomatous meningioma 10.3 CTNNB1 MME
17 adenofibroma 10.3 MME MUC1
18 intussusception 10.3
19 chronic orbital inflammation 10.3 MME MUC1
20 perivascular epithelioid cell tumor 10.3 MME MUC1
21 meningeal melanocytoma 10.2 MME MUC1
22 lobular neoplasia 10.2 CTNNB1 MUC1
23 polymorphous low-grade adenocarcinoma 10.2 CTNNB1 MUC1
24 pyloric stenosis 10.2
25 chronic ethmoiditis 10.2 MUC1 MUC4
26 sarcomatoid mesothelioma 10.2 MUC1 MUC4
27 filamentary keratitis 10.2 MUC1 MUC4
28 ethmoid sinusitis 10.2 MUC1 MUC4
29 limbal stem cell deficiency 10.2 MUC1 MUC4
30 pilomatrixoma 10.1 CTNNB1 MUC1
31 endometrial hyperplasia 10.1
32 leiomyoma 10.1
33 adenosarcoma 10.1
34 colorectal cancer 1 10.1 MUC1 MUC4
35 balloon cell malignant melanoma 10.1 KRT7 MME
36 cervical adenoma malignum 10.1 KRT7 MME
37 intestinal benign neoplasm 10.1 CTNNB1 MLH1
38 cervical mucinous adenocarcinoma 10.1 KRT7 MME
39 clear cell papillary renal cell carcinoma 10.1 KRT7 MME
40 malignant leydig cell tumor 10.0 KRT7 MME
41 bladder lymphoma 10.0 KRT7 MME
42 large intestine adenocarcinoma 10.0 CTNNB1 KRT7
43 lymphoma 10.0
44 hypertrophic pyloric stenosis 10.0
45 endometriosis 10.0
46 infertility 10.0
47 adenoma 10.0
48 peritonitis 10.0
49 lung acinar adenocarcinoma 10.0 CTNNB1 KRT7
50 kidney benign neoplasm 10.0 KRT7 MME

Graphical network of the top 20 diseases related to Adenomyoma:



Diseases related to Adenomyoma

Symptoms & Phenotypes for Adenomyoma

GenomeRNAi Phenotypes related to Adenomyoma according to GeneCards Suite gene sharing:

27 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.62 CTNNB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.62 CTNNB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.62 MLH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.62 MLH1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.62 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.62 MLH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.62 CTNNB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.62 KRT7
9 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.62 MLH1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.62 CTNNB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.62 CTNNB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.62 CTNNB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.62 CTNNB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.62 CTNNB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.62 CTNNB1 KRT7 MLH1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.62 MLH1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.62 CTNNB1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.62 MLH1

Drugs & Therapeutics for Adenomyoma

Drugs for Adenomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Letrozole Approved, Investigational Phase 2, Phase 3 112809-51-5 3902
2
Goserelin Approved Phase 2, Phase 3 65807-02-5 5311128 47725
3
Lactitol Investigational Phase 2, Phase 3 585-86-4, 585-88-6 493591
4 Aromatase Inhibitors Phase 2, Phase 3
5 Estrogen Receptor Antagonists Phase 2, Phase 3
6 Estrogen Antagonists Phase 2, Phase 3
7 Hormones Phase 2, Phase 3
8 Steroid Synthesis Inhibitors Phase 2, Phase 3
9 Antineoplastic Agents, Hormonal Phase 2, Phase 3
10 Hormone Antagonists Phase 2, Phase 3
11 Estrogens Phase 2, Phase 3
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
2 Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis Completed NCT01218581 Phase 2, Phase 3 received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)

Search NIH Clinical Center for Adenomyoma

Cochrane evidence based reviews: adenomyoma

Genetic Tests for Adenomyoma

Anatomical Context for Adenomyoma

MalaCards organs/tissues related to Adenomyoma:

42
Uterus, Small Intestine, Smooth Muscle, Liver, Ovary, Cervix, Pancreas

Publications for Adenomyoma

Articles related to Adenomyoma:

(show top 50) (show all 276)
# Title Authors Year
1
Sonographic diagnosis of an ileal adenomyoma in a neonate. ( 30549276 )
2019
2
Atypical polypoid adenomyoma of the uterus: A reappraisal of the clinicopathological and immunohistochemical features. ( 30661903 )
2019
3
Management of women with atypical polypoid adenomyoma of the uterus: a quantitative systematic review. ( 30714089 )
2019
4
Hysteroscopic Transcervical Resection for Atypical Polypoid Adenomyoma of the Uterus: A Valid, Fertility-Preserving Option. ( 29038039 )
2018
5
Combination of Adenomyoma and Adenomyomatous Hyperplasia of the Ampullary System: A First Case Report. ( 29618230 )
2018
6
Maintenance hormonal therapy after treatment with medroxyprogesterone acetate for patients with atypical polypoid adenomyoma. ( 29351618 )
2018
7
A case of rapidly-growing atypical polypoid adenomyoma which was histologically diagnosed before operation and removed by a laparoscopic resection. ( 29458879 )
2018
8
Uterine adenomyosis and adenomyoma: the surgical approach. ( 29566853 )
2018
9
Postoperative maintenance levonorgestrel-releasing intrauterine system for symptomatic uterine adenomyoma. ( 29458902 )
2018
10
Management of atypical polypoid adenomyoma of the uterus: A single center's experience. ( 29561413 )
2018
11
Extrauterine adenomyoma: a review of the literature. ( 29940416 )
2018
12
Pregnant outcomes of atypical polypoid adenomyoma treated with progestin therapy. ( 29121416 )
2018
13
Endometrioid Adenocarcinoma Arising in Adenomyoma in a Woman with a Genital Prolapse - Case Report. ( 29983808 )
2018
14
A rare case of a gastric adenomyoma mimicking a gastric duplication cyst. ( 30260786 )
2018
15
Cytomorphological features of atypical polypoid adenomyoma of the endometrium. ( 30556192 )
2018
16
SATB2 is Consistently Expressed in Squamous Morules Associated With Endometrioid Proliferative Lesions and in the Stroma of Atypical Polypoid Adenomyoma. ( 30085940 )
2018
17
Successful laparotomy tumor resection and levonorgestrel-releasing intrauterine system for atypical polypoid adenomyoma. ( 30094884 )
2018
18
MRI of prolapsed polypoid adenomyoma: Expanding the differential diagnosis for the broccoli sign. ( 30096556 )
2018
19
Recurrence-associated factors of laparoscopic adenomyomectomy for severely symptomatic adenomyoma. ( 30127945 )
2018
20
Cytological features of atypical polypoid adenomyoma of the endometrium: A case report with literature review. ( 28160434 )
2017
21
Clinicopathological Characteristics of Primary Ovarian Adenomyoma: A Single-institutional Experience. ( 28476828 )
2017
22
A Rapidly Enlarging MA1llerian-Derived Hepatic Adenomyoma Clinically Mimicking Hepatic Adenoma in a Pregnant Woman. ( 28766580 )
2017
23
Extrauterine Adenomyoma of the Liver in a 50 year old Female with Pelvic Endometriosis. ( 28442524 )
2017
24
Gastric Adenomyoma: The Unexpected Mimicker. ( 29255751 )
2017
25
Adenomyoma With Pseudoinvasive Growth Pattern and Serosal Penetration Mimicking Endometrial Carcinoma. ( 28700437 )
2017
26
Endoscopic submucosal dissection for gastric adenomyoma: A rare entity of 15 cases among 571 patients with gastric submucosal eminence lesions. ( 28248886 )
2017
27
Round Ligament Adenomyoma. ( 29269127 )
2017
28
Juvenile Cystic Adenomyoma Mimicking a Uterine Anomaly: a Report of Two Cases. ( 28416935 )
2017
29
Recurrent atypical polypoid adenomyoma and pregnancy: A new conservative approach with levonorgestrel-releasing intrauterine system. ( 28761925 )
2017
30
Endometrial adenomyoma polyp caused postmenopausal bleeding mimicking uterine malignancy. ( 30254897 )
2017
31
Parasitic Myomas and an Adenomyoma Obstructing the Ureter After Power Morcellation of Myomas and Endometriotic Nodule Resection. ( 27208606 )
2016
32
Gastric adenomyoma clinically simulating hypertrophic pyloric stenosis. ( 26837724 )
2016
33
An Unusual Case of Noninvasive Adenocarcinoma Arising in a Localized Adenomyoma of the Gallbladder and Review of Literature. ( 26721302 )
2016
34
EP27.09: Pelvic adenomyoma, eleven years after total hysterectomy: rare report and literature review. ( 27647499 )
2016
35
Adenomyoma of the common bile duct: a rare lesion diagnosed and treated by ERCP. ( 27509468 )
2016
36
Positron Emission Tomography Findings in Atypical Polypoid Adenomyoma. ( 27134711 )
2016
37
A mixed carcinoma of the uterus arising from an atypical polypoid adenomyoma: a case report. ( 29943938 )
2016
38
A novel laparoscopic surgical technique for severe adenomyoma. ( 30074314 )
2016
39
Decidualization of uterine adenomyoma in a pregnant woman: a case report with immunohistochemical study. ( 25182212 )
2015
40
Endocervical Atypical Polypoid Adenomyoma. ( 26304721 )
2015
41
Rare case of giant cystic adenomyoma mimicking a uterine malformation, diagnosed and treated by hysteroscopy. ( 25833279 )
2015
42
Long-term outcomes of fertility-sparing treatment of atypical polypoid adenomyoma with medroxyprogesterone acetate. ( 26209972 )
2015
43
Adenomyoma of the duodenum. ( 26263354 )
2015
44
MR manifestations of uterine polypoid adenomyoma. ( 25516215 )
2015
45
Laparoscopic Management of Juvenile Cystic Adenomyoma. ( 27678779 )
2015
46
Atypical Polypoid Adenomyoma of the Uterus: An Immunohistochemical and Molecular Study of 21 Cases. ( 25828387 )
2015
47
A coexistence case of right tubal adenomyoma and ectopic pregnancy. ( 24879049 )
2015
48
A case of endometrioid adenocarcinoma developing 8A years after conservative management for atypical polypoid adenomyoma. ( 24707458 )
2014
49
Polypoid adenomyoma of endocervical type. ( 25105047 )
2014
50
Large uterine cervical adenomyoma excised by vaginal approach: case report, images, and literature review. ( 24582628 )
2014

Variations for Adenomyoma

Expression for Adenomyoma

Search GEO for disease gene expression data for Adenomyoma.

Pathways for Adenomyoma

Pathways related to Adenomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.49 CTNNB1 MME

GO Terms for Adenomyoma

Cellular components related to Adenomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.02 CTNNB1 KRT7 MME MUC1 MUC4

Biological processes related to Adenomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.96 MUC1 MUC4
2 O-glycan processing GO:0016266 8.62 MUC1 MUC4

Sources for Adenomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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