MCID: ADN075
MIFTS: 36

Adenomyoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adenomyoma

MalaCards integrated aliases for Adenomyoma:

Name: Adenomyoma 12 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2609
MeSH 43 D018194
NCIt 49 C3726
SNOMED-CT 67 40293003
UMLS 71 C0206622

Summaries for Adenomyoma

Disease Ontology : 12 A carcinosarcoma that has material basis in gland and muscle components.

MalaCards based summary : Adenomyoma is related to cervical adenomyoma and atypical polypoid adenomyoma. An important gene associated with Adenomyoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Gastric cancer and Thyroid hormone signaling pathway. The drugs Norethindrone and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include breast, uterus and ovary, and related phenotype is neoplasm.

Wikipedia : 74 Adenomyoma is a tumor (-oma) including components derived from glands (adeno-) and muscle (-my-). It is... more...

Related Diseases for Adenomyoma

Diseases related to Adenomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 393)
# Related Disease Score Top Affiliating Genes
1 cervical adenomyoma 34.2 PGR MME
2 atypical polypoid adenomyoma 33.3 MME MLH1 MED12 CTNNB1 CALD1
3 adenomyosis 30.9 PGR MME GNRH1 ESR1 CTNNB1
4 adenofibroma 30.6 MUC1 MME KRT7
5 adenosarcoma 30.5 PGR MME ESR1
6 adenoma 30.3 MUC1 MLH1 KRT7 CTNNB1
7 endometrioid ovary carcinoma 30.3 MLH1 CTNNB1
8 adenocarcinoma 30.0 MUC4 MUC1 MLH1 KRT7 CTNNB1
9 pseudomyxoma peritonei 30.0 MUC1 KRT7 CTNNB1
10 bartholin's gland adenoma 30.0 PGR ESR1
11 endometrial hyperplasia 29.9 PGR MLH1 ESR1 CTNNB1
12 diffuse peritoneal leiomyomatosis 29.9 PGR MED12
13 cervical polyp 29.9 PGR MME CALD1
14 intravenous leiomyomatosis 29.8 PGR MME ESR1 CALD1
15 ectopic pregnancy 29.6 PGR MUC1 GNRH1
16 gallbladder cancer 29.6 MUC1 MLH1 KRT7 CTNNB1
17 in situ carcinoma 29.5 PGR MUC1 ESR1
18 intrahepatic cholangiocarcinoma 29.5 MUC4 MUC1 KRT7 CTNNB1
19 perivascular epithelioid cell tumor 29.5 PGR MUC1 MME CALD1
20 bile duct cancer 29.5 MUC4 MUC1 KRT7 CTNNB1
21 clear cell adenocarcinoma 29.5 PGR KRT7 ESR1
22 endometrial stromal sarcoma 29.3 PGR MME ESR1 CALD1
23 adenoid cystic carcinoma 29.3 PGR MUC1 KRT7 CTNNB1
24 estrogen excess 29.3 PGR GNRH1 ESR1
25 leiomyosarcoma 29.2 PGR MUC1 MED12 ESR1
26 cholangiocarcinoma 29.2 MUC4 MUC1 MME KRT7 CTNNB1
27 adenosquamous carcinoma 29.2 PGR MUC4 MUC1 KRT7
28 endometrial adenocarcinoma 29.1 PGR MUC1 MLH1 KRT7 ESR1 CTNNB1
29 vaginal discharge 29.0 PGR GNRH1 ESR1
30 leiomyoma 29.0 PGR MME MED12 GNRH1 ESR1
31 carcinosarcoma 29.0 PGR MUC1 MME KRT7 CTNNB1
32 leiomyomatosis 28.9 PGR MED12 GNRH1 ESR1
33 gastric adenocarcinoma 28.9 MUC4 MUC1 MLH1 KRT7 ESR1 CTNNB1
34 smooth muscle tumor 28.8 PGR MME MED12 ESR1 CALD1
35 mucinous adenocarcinoma 28.7 PGR MUC1 MLH1 KRT7 ESR1
36 leiomyoma, uterine 28.7 PGR MED12 GNRH1 ESR1
37 ovarian disease 28.6 PGR MLH1 GNRH1 ESR1
38 myoma 28.5 PGR MME MED12 GNRH1 ESR1 CALD1
39 endometrial cancer 28.1 PGR MUC1 MME MLH1 KRT7 GNRH1
40 ovarian cancer 27.1 PGR MUC4 MUC1 MLH1 KRT7 GNRH1
41 uterine corpus atypical polypoid adenomyoma 12.4
42 endocervical type cervical adenomyoma 12.4
43 endometrial type cervical adenomyoma 12.4
44 cervical atypical polypoid adenomyoma 12.4
45 adenomyoma of uterine corpus 12.2
46 bartholin's gland adenomyoma 12.2
47 endometriosis 10.5
48 intussusception 10.5
49 mixed endometrial stromal and smooth muscle tumor 10.5 MME CALD1
50 fallopian tube leiomyoma 10.5 MME CALD1

Graphical network of the top 20 diseases related to Adenomyoma:



Diseases related to Adenomyoma

Symptoms & Phenotypes for Adenomyoma

MGI Mouse Phenotypes related to Adenomyoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 CTNNB1 ESR1 GNRH1 MLH1 PGR

Drugs & Therapeutics for Adenomyoma

Drugs for Adenomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norethindrone Approved Phase 4 68-22-4 6230
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
3
Polyestradiol phosphate Approved Phase 4 28014-46-2
4
Buserelin Approved, Investigational Phase 4 57982-77-1
5
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
6 Estrogens Phase 4
7 Hormone Antagonists Phase 4
8 Hormones Phase 4
9 Norethindrone Acetate Phase 4
10 Estradiol 17 beta-cypionate Phase 4
11 Estradiol 3-benzoate Phase 4
12 Prolactin Release-Inhibiting Factors Phase 4
13 Triptorelin Pamoate Phase 4
14
Letrozole Approved, Investigational Phase 2, Phase 3 112809-51-5 3902
15
Goserelin Approved Phase 2, Phase 3 65807-02-5, 1233494-97-7 47725 5311128
16
Lactitol Investigational Phase 2, Phase 3 585-86-4, 585-88-6 493591
17 Aromatase Inhibitors Phase 2, Phase 3
18 Estrogen Antagonists Phase 2, Phase 3
19 Steroid Synthesis Inhibitors Phase 2, Phase 3
20 Estrogen Receptor Antagonists Phase 2, Phase 3
21 Antineoplastic Agents, Hormonal Phase 2, Phase 3
22 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Modified Downregulation for Women With Adenomyosis of the Uterus Prior to Frozen-thawed Embryo Transfer. Not yet recruiting NCT03946722 Phase 4 GnRH analogue downregulation
2 Aromatase Inhibitors or Gonadotropin-releasing Hormone Agonists for the Management of Uterine Adenomyosis: A Randomized Controlled Trial Completed NCT01218581 Phase 2, Phase 3 received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)
3 A Randomized, Controlled, Subject and Reviewer-Blinded, Multi-Centre Study To Assess The Safety and Manageability Of LABS™ In Women Undergoing Gynaecologic Laparoscopic Surgery Followed By Second Look Laparoscopy Completed NCT02260115 Phase 1
4 Microwave Ablation for Uterine Fibroids Recruiting NCT04073485

Search NIH Clinical Center for Adenomyoma

Cochrane evidence based reviews: adenomyoma

Genetic Tests for Adenomyoma

Anatomical Context for Adenomyoma

MalaCards organs/tissues related to Adenomyoma:

40
Breast, Uterus, Ovary, Colon, Smooth Muscle, Lung, Cervix

Publications for Adenomyoma

Articles related to Adenomyoma:

(show top 50) (show all 504)
# Title Authors PMID Year
1
Extrauterine adenomyomas presenting in a 47 year old woman with a previous cesarean section. 61
31872018 2020
2
Clinicopathologic Characteristics of Gallbladder Adenomyomas and the Contribution of Macroscopic Sampling in Adenomyoma Diagnosis. 61
31633192 2020
3
Endometrial Endometrioid Carcinoma With Ovarian Metastasis Showing Morula-like Features in a Patient With Cowden Syndrome: A Case Report. 61
30676432 2020
4
Luschka Ducts of the Gallbladder in Adults: Case Series Report and Review of the Medical Literature. 61
31983263 2020
5
Diagnosing adenomyosis with MRI: a prospective study revisiting the junctional zone thickness cutoff of 12 mm as a diagnostic marker. 61
31264010 2019
6
Mutations of RAS genes in endometrial polyps. 61
31638232 2019
7
Iatrogenic parasitic myoma and iatrogenic adenomyoma after laparoscopic morcellation: A mini-review. 61
31080671 2019
8
Stromal p16 Expression Helps Distinguish Atypical Polypoid Adenomyoma From Myoinvasive Endometrioid Carcinoma of the Uterus. 61
31600177 2019
9
Advanced uterine adenosarcoma with sarcomatous overgrowth in a young woman: A case report. 61
31764852 2019
10
Adenomyoma of the distal common bile duct demonstrated by endoscopic ultrasound: A case report and review of the literature. 61
31750345 2019
11
Peritoneal Keratin Granulomatosis Is a Clinical and Radiological Mimicker of Endometrial Adenocarcinoma With Peritoneal Involvement. 61
31113276 2019
12
Use of Augmented Reality in Gynecologic Surgery to Visualize Adenomyomas. 61
30965117 2019
13
Atypical polypoid adenomyoma treated by hysteroscopy with photodynamic diagnosis using 5-aminolevulinic acid: A case report. 61
31252140 2019
14
SATB2 is Consistently Expressed in Squamous Morules Associated With Endometrioid Proliferative Lesions and in the Stroma of Atypical Polypoid Adenomyoma. 61
30085940 2019
15
Adenocarcinoma arising in adenomyoma of small intestine. 61
31338919 2019
16
Juvenile cystic adenomyoma mimicking a Mullerian uterine anomaly successfully treated by laparoscopic excision. 61
31179545 2019
17
Preserving Fertility by Treating the 3 Compartments: Laparoscopic Approach to Deep Infiltrating Endometriosis. 61
30195079 2019
18
Management of women with atypical polypoid adenomyoma of the uterus: A quantitative systematic review. 61
30714089 2019
19
MR-guided focused ultrasound surgery: A novel non-invasive technique in the treatment of adenomyosis -18 month's follow-up of 12 cases. 61
31741597 2019
20
Hysteroscopic Treatment of Symptomatic Adenomyoma 61
31245966 2019
21
Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis. 61
31855579 2019
22
Cytomorphological features of atypical polypoid adenomyoma of the endometrium. 61
30556192 2019
23
A case of incidental endometrial adenocarcinoma diagnosed in early pregnancy and managed conservatively. 61
30993161 2019
24
Atypical polypoid adenomyoma of the uterus: A reappraisal of the clinicopathological and immunohistochemical features. 61
30661903 2019
25
Polypoid Adenomyoma of the Uterus. 61
31016072 2019
26
Sonographic diagnosis of an ileal adenomyoma in a neonate. 61
30549276 2019
27
Clinicopathological and immunohistochemical features of uterine adenomyomatous polyps. 61
30339971 2019
28
Incidental Gynecologic Tract Neoplasms in Women Undergoing Anterior Pelvic Exenteration for Urothelial Carcinoma. 61
29257039 2019
29
Uncommon Mixed Endometrial-Myometrial Benign Tumors of the Reproductive Tract: Literature Review. 61
30889596 2019
30
Simultaneously occurring disseminated peritoneal leiomyomatosis and multiple extrauterine adenomyomas following hysterectomy. 61
30956607 2019
31
Successful laparotomy tumor resection and levonorgestrel-releasing intrauterine system for atypical polypoid adenomyoma. 61
30094884 2019
32
MRI of prolapsed polypoid adenomyoma: Expanding the differential diagnosis for the broccoli sign. 61
30096556 2018
33
A sonographic classification of adenomyosis: interobserver reproducibility in the evaluation of type and degree of the myometrial involvement. 61
30396560 2018
34
Combination of Adenomyoma and Adenomyomatous Hyperplasia of the Ampullary System: A First Case Report. 61
29618230 2018
35
A rare case of a gastric adenomyoma mimicking a gastric duplication cyst. 61
30260786 2018
36
Recurrence-associated factors of laparoscopic adenomyomectomy for severely symptomatic adenomyoma. 61
30127945 2018
37
Extrauterine adenomyoma: a review of the literature. 61
29940416 2018
38
Round Ligament Adenomyoma. 61
29269127 2018
39
Minimally invasive treatment of adenomyosis. 61
29555380 2018
40
Adenomyoma With Pseudoinvasive Growth Pattern and Serosal Penetration Mimicking Endometrial Carcinoma. 61
28700437 2018
41
Endometrioid Adenocarcinoma Arising in Adenomyoma in a Woman with a Genital Prolapse - Case Report. 61
29983808 2018
42
Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over. 61
29786043 2018
43
Maintenance hormonal therapy after treatment with medroxyprogesterone acetate for patients with atypical polypoid adenomyoma. 61
29351618 2018
44
Uterine adenomyosis and adenomyoma: the surgical approach. 61
29566853 2018
45
Management of atypical polypoid adenomyoma of the uterus: A single center's experience. 61
29561413 2018
46
A case of rapidly-growing atypical polypoid adenomyoma which was histologically diagnosed before operation and removed by a laparoscopic resection. 61
29458879 2018
47
[Analysis of characteristics and influence factors of diagnostic delay of endometriosis]. 61
29534377 2018
48
Conservative Surgery for Adenomyosis and Results: A Systematic Review. 61
28739414 2018
49
Postoperative maintenance levonorgestrel-releasing intrauterine system for symptomatic uterine adenomyoma. 61
29458902 2018
50
Pregnant outcomes of atypical polypoid adenomyoma treated with progestin therapy. 61
29121416 2018

Variations for Adenomyoma

Expression for Adenomyoma

Search GEO for disease gene expression data for Adenomyoma.

Pathways for Adenomyoma

Pathways related to Adenomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 PGR MLH1 ESR1 CTNNB1
2 10.87 MED12 ESR1 CTNNB1

GO Terms for Adenomyoma

Biological processes related to Adenomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.13 PGR MED12 ESR1
2 embryonic brain development GO:1990403 8.62 MED12 CTNNB1

Molecular functions related to Adenomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.26 MLH1 MED12 ESR1 CTNNB1
2 steroid binding GO:0005496 9.16 PGR ESR1
3 enzyme binding GO:0019899 8.92 PGR MLH1 ESR1 CTNNB1

Sources for Adenomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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