MCID: ADN075
MIFTS: 36

Adenomyoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adenomyoma

MalaCards integrated aliases for Adenomyoma:

Name: Adenomyoma 12 44 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:2609
MeSH 44 D018194
NCIt 50 C3726
SNOMED-CT 68 40293003
UMLS 72 C0206622

Summaries for Adenomyoma

Disease Ontology : 12 A carcinosarcoma that has material basis in gland and muscle components.

MalaCards based summary : Adenomyoma is related to atypical polypoid adenomyoma and adenofibroma. An important gene associated with Adenomyoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways is Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Progesterone and Norethindrone have been mentioned in the context of this disorder. Affiliated tissues include uterus, small intestine and pancreas.

Wikipedia : 75 Adenomyoma is a tumor (-oma) including components derived from glands (adeno-) and muscle (-my-). It is... more...

Related Diseases for Adenomyoma

Diseases related to Adenomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 atypical polypoid adenomyoma 32.7 MME MLH1 MED12 CTNNB1
2 adenofibroma 31.1 MUC1 MME
3 perivascular epithelioid cell tumor 30.5 MUC1 MME
4 endometrial adenocarcinoma 30.3 MLH1 KRT7 CTNNB1
5 ampulla of vater adenocarcinoma 30.3 MUC1 KRT7
6 spindle cell sarcoma 30.3 MUC1 KRT7
7 pseudomyxoma peritonei 30.2 MUC1 KRT7
8 endometrial cancer 30.0 MME MLH1 KRT7 CTNNB1
9 adenocarcinoma 29.8 MUC4 MUC1 MLH1 CTNNB1
10 adenoid cystic carcinoma 29.7 MUC1 KRT7 CTNNB1
11 adenosquamous carcinoma 29.6 MUC4 MUC1 KRT7
12 mucinous adenocarcinoma 29.5 MUC1 MLH1 KRT7
13 carcinosarcoma 29.3 MUC1 MME KRT7 CTNNB1
14 intrahepatic cholangiocarcinoma 29.1 MUC4 MUC1 KRT7 CTNNB1
15 ovarian cancer 28.9 MUC1 MLH1 KRT7 CTNNB1
16 gastric adenocarcinoma 28.5 MUC4 MUC1 MLH1 KRT7 CTNNB1
17 cholangiocarcinoma 28.5 MUC4 MUC1 MME KRT7 CTNNB1
18 cervical adenomyoma 12.6
19 uterine corpus atypical polypoid adenomyoma 12.4
20 endocervical type cervical adenomyoma 12.4
21 endometrial type cervical adenomyoma 12.4
22 cervical atypical polypoid adenomyoma 12.4
23 adenomyoma of uterine corpus 12.2
24 bartholin's gland adenomyoma 12.2
25 adenomyosis 11.6
26 endometriosis 10.5
27 leiomyoma 10.5
28 psammomatous meningioma 10.5 MME CTNNB1
29 intussusception 10.5
30 adenosarcoma 10.5
31 chronic orbital inflammation 10.4 MUC1 MME
32 endometrial hyperplasia 10.4
33 adenoma 10.4
34 balloon cell malignant melanoma 10.4 MME KRT7
35 cervical adenoma malignum 10.4 MME KRT7
36 clear cell papillary renal cell carcinoma 10.4 MME KRT7
37 cervical mucinous adenocarcinoma 10.4 MME KRT7
38 meningeal melanocytoma 10.4 MUC1 MME
39 myoma 10.4
40 lobular neoplasia 10.4 MUC1 CTNNB1
41 malignant leydig cell tumor 10.4 MME KRT7
42 bladder lymphoma 10.4 MME KRT7
43 lung acinar adenocarcinoma 10.4 KRT7 CTNNB1
44 kidney benign neoplasm 10.3 MME KRT7
45 large intestine adenocarcinoma 10.3 KRT7 CTNNB1
46 papillary craniopharyngioma 10.3 KRT7 CTNNB1
47 breast myoepithelial neoplasm 10.3 MME KRT7
48 craniopharyngioma 10.3 KRT7 CTNNB1
49 breast adenomyoepithelioma 10.3 MME KRT7
50 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.3

Graphical network of the top 20 diseases related to Adenomyoma:



Diseases related to Adenomyoma

Symptoms & Phenotypes for Adenomyoma

Drugs & Therapeutics for Adenomyoma

Drugs for Adenomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
2
Norethindrone Approved Phase 4 68-22-4 6230
3
Polyestradiol phosphate Approved Phase 4 28014-46-2
4
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
5
Buserelin Approved, Investigational Phase 4 57982-77-1
6 Estrogens Phase 4
7 Hormones Phase 4
8 Hormone Antagonists Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
10 Triptorelin Pamoate Phase 4
11 Norethindrone Acetate Phase 4
12 Prolactin Release-Inhibiting Factors Phase 4
13 Estradiol 3-benzoate Phase 4
14 Estradiol 17 beta-cypionate Phase 4
15
Goserelin Approved Phase 2, Phase 3 65807-02-5, 1233494-97-7 47725 5311128
16
Letrozole Approved, Investigational Phase 2, Phase 3 112809-51-5 3902
17
Lactitol Investigational Phase 2, Phase 3 585-86-4, 585-88-6 493591
18 Steroid Synthesis Inhibitors Phase 2, Phase 3
19 Antineoplastic Agents, Hormonal Phase 2, Phase 3
20 Estrogen Receptor Antagonists Phase 2, Phase 3
21 Estrogen Antagonists Phase 2, Phase 3
22 Aromatase Inhibitors Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Modified Downregulation for Women With Adenomyosis of the Uterus Prior to Frozen-thawed Embryo Transfer. Not yet recruiting NCT03946722 Phase 4 GnRH analogue downregulation
2 Aromatase Inhibitors or Gonadotropin-releasing Hormone Agonists for the Management of Uterine Adenomyosis: A Randomized Controlled Trial Completed NCT01218581 Phase 2, Phase 3 received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)
3 A Randomized, Controlled, Subject and Reviewer-Blinded, Multi-Centre Study To Assess The Safety and Manageability Of LABS™ In Women Undergoing Gynaecologic Laparoscopic Surgery Followed By Second Look Laparoscopy Completed NCT02260115 Phase 1

Search NIH Clinical Center for Adenomyoma

Cochrane evidence based reviews: adenomyoma

Genetic Tests for Adenomyoma

Anatomical Context for Adenomyoma

MalaCards organs/tissues related to Adenomyoma:

41
Uterus, Small Intestine, Pancreas, Cervix, Smooth Muscle, Ovary, Colon

Publications for Adenomyoma

Articles related to Adenomyoma:

(show top 50) (show all 495)
# Title Authors PMID Year
1
Iatrogenic parasitic myoma and iatrogenic adenomyoma after laparoscopic morcellation: A mini-review. 38
31080671 2019
2
SATB2 is Consistently Expressed in Squamous Morules Associated With Endometrioid Proliferative Lesions and in the Stroma of Atypical Polypoid Adenomyoma. 38
30085940 2019
3
Juvenile cystic adenomyoma mimicking a Mullerian uterine anomaly successfully treated by laparoscopic excision. 38
31179545 2019
4
Adenocarcinoma arising in adenomyoma of small intestine. 38
31338919 2019
5
Diagnosing adenomyosis with MRI: a prospective study revisiting the junctional zone thickness cutoff of 12 mm as a diagnostic marker. 38
31264010 2019
6
Preserving Fertility by Treating the 3 Compartments: Laparoscopic Approach to Deep Infiltrating Endometriosis. 38
30195079 2019
7
Management of women with atypical polypoid adenomyoma of the uterus: A quantitative systematic review. 38
30714089 2019
8
Hysteroscopic Treatment of Symptomatic Adenomyoma 38
31245966 2019
9
Atypical polypoid adenomyoma treated by hysteroscopy with photodynamic diagnosis using 5-aminolevulinic acid: A case report. 38
31252140 2019
10
Cytomorphological features of atypical polypoid adenomyoma of the endometrium. 38
30556192 2019
11
Peritoneal Keratin Granulomatosis Is a Clinical and Radiological Mimicker of Endometrial Adenocarcinoma With Peritoneal Involvement. 38
31113276 2019
12
A case of incidental endometrial adenocarcinoma diagnosed in early pregnancy and managed conservatively. 38
30993161 2019
13
Use of Augmented Reality in Gynecologic Surgery to Visualize Adenomyomas. 38
30965117 2019
14
Atypical polypoid adenomyoma of the uterus: A reappraisal of the clinicopathological and immunohistochemical features. 38
30661903 2019
15
Uncommon Mixed Endometrial-Myometrial Benign Tumors of the Reproductive Tract: Literature Review. 38
30889596 2019
16
Polypoid Adenomyoma of the Uterus. 38
31016072 2019
17
Sonographic diagnosis of an ileal adenomyoma in a neonate. 38
30549276 2019
18
Clinicopathological and immunohistochemical features of uterine adenomyomatous polyps. 38
30339971 2019
19
Endometrial Endometrioid Carcinoma With Ovarian Metastasis Showing Morula-like Features in a Patient With Cowden Syndrome: A Case Report. 38
30676432 2019
20
Simultaneously occurring disseminated peritoneal leiomyomatosis and multiple extrauterine adenomyomas following hysterectomy. 38
30956607 2019
21
Incidental Gynecologic Tract Neoplasms in Women Undergoing Anterior Pelvic Exenteration for Urothelial Carcinoma. 38
29257039 2019
22
Successful laparotomy tumor resection and levonorgestrel-releasing intrauterine system for atypical polypoid adenomyoma. 38
30094884 2019
23
A sonographic classification of adenomyosis: interobserver reproducibility in the evaluation of type and degree of the myometrial involvement. 38
30396560 2018
24
MRI of prolapsed polypoid adenomyoma: Expanding the differential diagnosis for the broccoli sign. 38
30096556 2018
25
Combination of Adenomyoma and Adenomyomatous Hyperplasia of the Ampullary System: A First Case Report. 38
29618230 2018
26
A rare case of a gastric adenomyoma mimicking a gastric duplication cyst. 38
30260786 2018
27
Recurrence-associated factors of laparoscopic adenomyomectomy for severely symptomatic adenomyoma. 38
30127945 2018
28
Round Ligament Adenomyoma. 38
29269127 2018
29
Extrauterine adenomyoma: a review of the literature. 38
29940416 2018
30
Minimally invasive treatment of adenomyosis. 38
29555380 2018
31
Adenomyoma With Pseudoinvasive Growth Pattern and Serosal Penetration Mimicking Endometrial Carcinoma. 38
28700437 2018
32
Endometrioid Adenocarcinoma Arising in Adenomyoma in a Woman with a Genital Prolapse - Case Report. 38
29983808 2018
33
Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over. 38
29786043 2018
34
Maintenance hormonal therapy after treatment with medroxyprogesterone acetate for patients with atypical polypoid adenomyoma. 38
29351618 2018
35
Uterine adenomyosis and adenomyoma: the surgical approach. 38
29566853 2018
36
Management of atypical polypoid adenomyoma of the uterus: A single center's experience. 38
29561413 2018
37
A case of rapidly-growing atypical polypoid adenomyoma which was histologically diagnosed before operation and removed by a laparoscopic resection. 38
29458879 2018
38
[Analysis of characteristics and influence factors of diagnostic delay of endometriosis]. 38
29534377 2018
39
Conservative Surgery for Adenomyosis and Results: A Systematic Review. 38
28739414 2018
40
Pregnant outcomes of atypical polypoid adenomyoma treated with progestin therapy. 38
29121416 2018
41
Postoperative maintenance levonorgestrel-releasing intrauterine system for symptomatic uterine adenomyoma. 38
29458902 2018
42
Hysteroscopic Transcervical Resection for Atypical Polypoid Adenomyoma of the Uterus: A Valid, Fertility-Preserving Option. 38
29038039 2018
43
The Investigation and Management of Adenomyosis in Women Who Wish to Improve or Preserve Fertility. 38
29736395 2018
44
MED12 mutations and fumarate hydratase inactivation in uterine adenomyomas. 38
30895261 2018
45
Endometrial stromal sarcoma in a 27-year-old woman. Case report and literature review. 38
30534836 2018
46
Molecular characterization, prevalence and clinical relevance of Phodopus sungorus papillomavirus type 1 (PsuPV1) naturally infecting Siberian hamsters (Phodopus sungorus). 38
29022861 2017
47
Recurrent atypical polypoid adenomyoma and pregnancy: A new conservative approach with levonorgestrel-releasing intrauterine system. 38
28761925 2017
48
A Rapidly Enlarging Müllerian-Derived Hepatic Adenomyoma Clinically Mimicking Hepatic Adenoma in a Pregnant Woman. 38
28766580 2017
49
Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome. 38
28288139 2017
50
Routine histopathological study of cholecystectomy specimens. Useful? A retrospective study of 1960 cases. 38
29560664 2017

Variations for Adenomyoma

Expression for Adenomyoma

Search GEO for disease gene expression data for Adenomyoma.

Pathways for Adenomyoma

Pathways related to Adenomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.49 MME CTNNB1

GO Terms for Adenomyoma

Cellular components related to Adenomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.02 MUC4 MUC1 MME KRT7 CTNNB1

Biological processes related to Adenomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 canonical Wnt signaling pathway GO:0060070 9.37 MED12 CTNNB1
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.32 MUC4 MUC1
3 O-glycan processing GO:0016266 9.26 MUC4 MUC1
4 stem cell population maintenance GO:0019827 9.16 MED12 CTNNB1
5 androgen receptor signaling pathway GO:0030521 8.65 CTNNB1
6 embryonic brain development GO:1990403 8.62 MED12 CTNNB1

Molecular functions related to Adenomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 8.8 MLH1 MED12 CTNNB1

Sources for Adenomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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