Aliases & Classifications for Adenomyoma

MalaCards integrated aliases for Adenomyoma:

Name: Adenomyoma 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2609
MeSH 44 D018194
NCIt 50 C3726
SNOMED-CT 68 40293003
UMLS 73 C0206622

Summaries for Adenomyoma

Disease Ontology : 12 A carcinosarcoma that has material basis in gland and muscle components.

MalaCards based summary : Adenomyoma is related to atypical polypoid adenomyoma and endometrial adenocarcinoma. An important gene associated with Adenomyoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and O-linked glycosylation. The drugs Goserelin and Letrozole have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Adenomyoma is a tumor (-oma) including components derived from glands (adeno-) and muscle (-my-). It is... more...

Related Diseases for Adenomyoma

Diseases related to Adenomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 atypical polypoid adenomyoma 32.3 CTNNB1 MLH1 MME MUC6
2 endometrial adenocarcinoma 29.1 KRT7 MLH1
3 adenocarcinoma 29.1 CTNNB1 MLH1 MUC1 MUC4
4 pseudomyxoma peritonei 28.8 KRT7 MUC1 MUC6
5 cervical adenomyoma 12.0
6 bartholin's gland adenomyoma 11.9
7 adenomyoma of uterine corpus 11.9
8 uterine corpus atypical polypoid adenomyoma 11.9
9 endocervical type cervical adenomyoma 11.9
10 endometrial type cervical adenomyoma 11.9
11 cervical atypical polypoid adenomyoma 11.9
12 adenomyosis 11.3
13 adenofibroma 10.6 MME MUC1
14 perivascular epithelioid cell tumor 10.6 MME MUC1
15 psammomatous meningioma 10.6 CTNNB1 MME
16 chronic orbital inflammation 10.5 MME MUC1
17 meningeal melanocytoma 10.5 MME MUC1
18 lobular neoplasia 10.5 CTNNB1 MUC1
19 pancreatic intraductal papillary-mucinous neoplasm 10.5 MUC1 MUC6
20 tumor of exocrine pancreas 10.5 MUC1 MUC6
21 microcystic adenoma 10.4 MUC1 MUC6
22 tn polyagglutination syndrome 10.4 MUC1 MUC6
23 polymorphous low-grade adenocarcinoma 10.4 CTNNB1 MUC1
24 sarcomatoid mesothelioma 10.4 MUC1 MUC4
25 filamentary keratitis 10.4 MUC1 MUC4
26 limbal stem cell deficiency 10.4 MUC1 MUC4
27 mixed ductal-endocrine carcinoma 10.3 MUC1 MUC6
28 pilomatrixoma 10.3 CTNNB1 MUC1
29 atypical teratoid rhabdoid tumor 10.3 CTNNB1 MUC1
30 epstein-barr virus-associated gastric carcinoma 10.2 CTNNB1 MUC6
31 cholecystitis 10.2 MUC1 MUC6
32 polyposis syndrome, hereditary mixed, 1 10.2 MLH1 MUC6
33 dry eye syndrome 10.2 MUC1 MUC4
34 balloon cell malignant melanoma 10.1 KRT7 MME
35 cervical adenoma malignum 10.1 KRT7 MME
36 cervical mucinous adenocarcinoma 10.1 KRT7 MME
37 clear cell papillary renal cell carcinoma 10.1 KRT7 MME
38 malignant leydig cell tumor 10.1 KRT7 MME
39 bladder lymphoma 10.1 KRT7 MME
40 solid adenocarcinoma with mucin production 10.1 KRT7 MUC1
41 endosalpingiosis 10.1 KRT7 MUC1
42 kidney benign neoplasm 10.1 KRT7 MME
43 parachordoma 10.1 KRT7 MUC1
44 intestinal benign neoplasm 10.1 CTNNB1 MLH1
45 middle ear adenoma 10.1 KRT7 MUC1
46 breast adenomyoepithelioma 10.1 KRT7 MME
47 breast myoepithelial neoplasm 10.1 KRT7 MME
48 malignant mixed mullerian tumor 10.1 KRT7 MUC1
49 mucinous bronchioloalveolar adenocarcinoma 10.1 KRT7 MUC1
50 nodular hidradenoma 10.1 KRT7 MUC1

Graphical network of the top 20 diseases related to Adenomyoma:



Diseases related to Adenomyoma

Symptoms & Phenotypes for Adenomyoma

GenomeRNAi Phenotypes related to Adenomyoma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.62 CTNNB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.62 CTNNB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.62 MLH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.62 MLH1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.62 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.62 MLH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.62 CTNNB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.62 KRT7
9 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.62 MLH1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.62 CTNNB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.62 CTNNB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.62 CTNNB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.62 CTNNB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.62 CTNNB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.62 CTNNB1 KRT7 MLH1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.62 MLH1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.62 CTNNB1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.62 MLH1

Drugs & Therapeutics for Adenomyoma

Drugs for Adenomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Goserelin Approved Phase 2, Phase 3 65807-02-5 47725 5311128
2
Letrozole Approved, Investigational Phase 2, Phase 3 112809-51-5 3902
3
Lactitol Investigational Phase 2, Phase 3 585-86-4 3871
4 Antineoplastic Agents, Hormonal Phase 2, Phase 3
5 Aromatase Inhibitors Phase 2, Phase 3
6 Estrogen Antagonists Phase 2, Phase 3
7 Estrogens Phase 2, Phase 3
8 Hormone Antagonists Phase 2, Phase 3
9 Hormones Phase 2, Phase 3
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
11 Steroid Synthesis Inhibitors Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
2 Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis Completed NCT01218581 Phase 2, Phase 3 received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)

Search NIH Clinical Center for Adenomyoma

Cochrane evidence based reviews: adenomyoma

Genetic Tests for Adenomyoma

Anatomical Context for Adenomyoma

MalaCards organs/tissues related to Adenomyoma:

41
Uterus, Cervix, Ovary, Thyroid, Liver, Small Intestine

Publications for Adenomyoma

Articles related to Adenomyoma:

(show top 50) (show all 111)
# Title Authors Year
1
Hysteroscopic Transcervical Resection for Atypical Polypoid Adenomyoma of the Uterus: A Valid, Fertility-Preserving Option. ( 29038039 )
2018
2
Combination of Adenomyoma and Adenomyomatous Hyperplasia of the Ampullary System: A First Case Report. ( 29618230 )
2018
3
Maintenance hormonal therapy after treatment with medroxyprogesterone acetate for patients with atypical polypoid adenomyoma. ( 29351618 )
2018
4
A case of rapidly-growing atypical polypoid adenomyoma which was histologically diagnosed before operation and removed by a laparoscopic resection. ( 29458879 )
2018
5
Uterine adenomyosis and adenomyoma: the surgical approach. ( 29566853 )
2018
6
Postoperative maintenance levonorgestrel-releasing intrauterine system for symptomatic uterine adenomyoma. ( 29458902 )
2018
7
Management of atypical polypoid adenomyoma of the uterus: A single center's experience. ( 29561413 )
2018
8
Extrauterine adenomyoma: a review of the literature. ( 29940416 )
2018
9
Pregnant outcomes of atypical polypoid adenomyoma treated with progestin therapy. ( 29121416 )
2018
10
Cytological features of atypical polypoid adenomyoma of the endometrium: A case report with literature review. ( 28160434 )
2017
11
Clinicopathological Characteristics of Primary Ovarian Adenomyoma: A Single-institutional Experience. ( 28476828 )
2017
12
A Rapidly Enlarging MA1llerian-Derived Hepatic Adenomyoma Clinically Mimicking Hepatic Adenoma in a Pregnant Woman. ( 28766580 )
2017
13
Extrauterine Adenomyoma of the Liver in a 50 year old Female with Pelvic Endometriosis. ( 28442524 )
2017
14
Gastric Adenomyoma: The Unexpected Mimicker. ( 29255751 )
2017
15
Adenomyoma With Pseudoinvasive Growth Pattern and Serosal Penetration Mimicking Endometrial Carcinoma. ( 28700437 )
2017
16
Endoscopic submucosal dissection for gastric adenomyoma: A rare entity of 15 cases among 571 patients with gastric submucosal eminence lesions. ( 28248886 )
2017
17
Round Ligament Adenomyoma. ( 29269127 )
2017
18
Juvenile Cystic Adenomyoma Mimicking a Uterine Anomaly: a Report of Two Cases. ( 28416935 )
2017
19
Recurrent atypical polypoid adenomyoma and pregnancy: A new conservative approach with levonorgestrel-releasing intrauterine system. ( 28761925 )
2017
20
Parasitic Myomas and an Adenomyoma Obstructing the Ureter After Power Morcellation of Myomas and Endometriotic Nodule Resection. ( 27208606 )
2016
21
Gastric adenomyoma clinically simulating hypertrophic pyloric stenosis. ( 26837724 )
2016
22
An Unusual Case of Noninvasive Adenocarcinoma Arising in a Localized Adenomyoma of the Gallbladder and Review of Literature. ( 26721302 )
2016
23
EP27.09: Pelvic adenomyoma, eleven years after total hysterectomy: rare report and literature review. ( 27647499 )
2016
24
Adenomyoma of the common bile duct: a rare lesion diagnosed and treated by ERCP. ( 27509468 )
2016
25
Positron Emission Tomography Findings in Atypical Polypoid Adenomyoma. ( 27134711 )
2016
26
A mixed carcinoma of the uterus arising from an atypical polypoid adenomyoma: a case report. ( 29943938 )
2016
27
Decidualization of uterine adenomyoma in a pregnant woman: a case report with immunohistochemical study. ( 25182212 )
2015
28
Endocervical Atypical Polypoid Adenomyoma. ( 26304721 )
2015
29
Rare case of giant cystic adenomyoma mimicking a uterine malformation, diagnosed and treated by hysteroscopy. ( 25833279 )
2015
30
Long-term outcomes of fertility-sparing treatment of atypical polypoid adenomyoma with medroxyprogesterone acetate. ( 26209972 )
2015
31
Adenomyoma of the duodenum. ( 26263354 )
2015
32
MR manifestations of uterine polypoid adenomyoma. ( 25516215 )
2015
33
Laparoscopic Management of Juvenile Cystic Adenomyoma. ( 27678779 )
2015
34
Atypical Polypoid Adenomyoma of the Uterus: An Immunohistochemical and Molecular Study of 21 Cases. ( 25828387 )
2015
35
A case of endometrioid adenocarcinoma developing 8A years after conservative management for atypical polypoid adenomyoma. ( 24707458 )
2014
36
Polypoid adenomyoma of endocervical type. ( 25105047 )
2014
37
Large uterine cervical adenomyoma excised by vaginal approach: case report, images, and literature review. ( 24582628 )
2014
38
Coexistence of endometrioid adenocarcinoma in atypical polypoid adenomyoma. ( 25612673 )
2014
39
Magnetic Resonance Imaging Findings in Atypical Polypoid Adenomyoma. ( 25286280 )
2014
40
Endometrioid adenocarcinoma in an extrauterine adenomyoma. ( 25004322 )
2014
41
Frequent I^-catenin gene mutations in atypical polypoid adenomyoma of the uterus. ( 24182564 )
2014
42
Hysteroscopic transcervical resection is useful to diagnose myometrial invasion in atypical polypoid adenomyoma coexisting with atypical endometrial hyperplasia or endometrial cancer with suspicious myometrial invasion. ( 25491392 )
2014
43
Clear Cell Adenocarcinoma Arising in an Adenomyoma of the Broad Ligament. ( 24942896 )
2014
44
Gastric adenomyoma in the stomach body: a case report. ( 25418949 )
2014
45
Medical treatment for adenomyosis and/or adenomyoma. ( 25510683 )
2014
46
Adenomyoma of the small intestine a rare pathological lead point for intussusception in an infant. ( 25392787 )
2014
47
Comment on case report entitled: adenomyosis of uterus with adenomyoma of fallopian tube. ( 25368467 )
2014
48
Clinical management of atypical polypoid adenomyoma of the uterus. A clinicopathological review of 29 cases. ( 23290989 )
2013
49
Radiological findings of gastric adenomyoma in a neonate presenting with gastric outlet obstruction. ( 23052729 )
2013
50
Atypical polypoid adenomyoma mixed with endometrioid carcinoma: a case report. ( 23590013 )
2013

Variations for Adenomyoma

Expression for Adenomyoma

Search GEO for disease gene expression data for Adenomyoma.

Pathways for Adenomyoma

GO Terms for Adenomyoma

Cellular components related to Adenomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC1 MUC4 MUC6

Biological processes related to Adenomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 maintenance of gastrointestinal epithelium GO:0030277 9.16 MUC4 MUC6
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 MUC1 MUC4 MUC6
3 O-glycan processing GO:0016266 8.8 MUC1 MUC4 MUC6

Sources for Adenomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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