MCID: ADN020
MIFTS: 44

Adenosarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Adenosarcoma

MalaCards integrated aliases for Adenosarcoma:

Name: Adenosarcoma 12 56 45 15 17 74
Mullerian Adenosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1974
MeSH 45 D018195
NCIt 51 C9474
SNOMED-CT 69 31470003
UMLS 74 C0001442

Summaries for Adenosarcoma

Disease Ontology : 12 A carcinosarcoma that derives from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

MalaCards based summary : Adenosarcoma, also known as mullerian adenosarcoma, is related to adenofibroma and cystadenoma. An important gene associated with Adenosarcoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Gastric cancer and LKB1 signaling events. The drugs Ipilimumab and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include breast, uterus and cervix, and related phenotypes are cardiovascular system and cellular

Wikipedia : 77 Adenosarcoma (also Mullerian Adenosarcoma) is a rare malignant tumor that occurs in women of all age... more...

Related Diseases for Adenosarcoma

Diseases related to Adenosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 248)
# Related Disease Score Top Affiliating Genes
1 adenofibroma 30.7 ACTC1 MME
2 cystadenoma 30.4 MME PGR
3 adenomyosis 30.2 ESR1 MME PGR
4 ovarian fibrothecoma 30.0 ACTC1 DES KIT
5 uterine carcinosarcoma 29.6 KIT MME PGR TP53
6 rhabdomyosarcoma 29.5 ACTC1 DES MB TP53
7 endometrial adenocarcinoma 29.2 ESR1 MKI67 PGR TP53
8 carcinosarcoma 29.1 ACTC1 DES KIT MME PGR TP53
9 gastrointestinal stromal tumor 29.1 ACTC1 DES KIT MKI67 TP53
10 smooth muscle tumor 28.6 ACTC1 DES ESR1 KIT MME PGR
11 adenosarcoma of the uterus 12.6
12 ovarian mesodermal adenosarcoma 12.5
13 uterine corpus adenosarcoma 12.4
14 cervical adenosarcoma 12.3
15 vaginal adenosarcoma 12.3
16 fallopian tube adenosarcoma 12.1
17 adenosarcoma of the cervix uteri 12.1
18 adenosarcoma of the corpus uteri 12.0
19 wilms tumor 5 11.2
20 blastema predominant kidney wilms' tumor 11.0
21 epithelial predominant wilms' tumor 11.0
22 endometriosis 10.6
23 spermatocele 10.4 MME PGR
24 endometrial stromal tumor 10.4 MME PGR
25 pancreatic mucinous cystadenoma 10.4 MME PGR
26 renal oncocytoma 10.4 KIT MME
27 congenital epulis 10.4 DES PGR
28 ovarian brenner tumor 10.4 KIT MME
29 rete testis neoplasm 10.4 KIT MME
30 dermoid cyst 10.3 KIT PGR
31 dysgerminoma of ovary 10.3 KIT PGR
32 lymphangiomatosis 10.3 DES PGR
33 meningioma, radiation-induced 10.3 MKI67 PGR
34 benign meningioma 10.3 MKI67 PGR
35 eccrine sweat gland neoplasm 10.3 MME TP53
36 epulis 10.3 DES PGR
37 central nervous system hematologic cancer 10.3 MME TP53
38 mature b-cell neoplasm 10.3 MME TP53
39 gallbladder sarcoma 10.3 DES KIT
40 hemangiopericytoma, malignant 10.3 ACTC1 DES
41 congenital mesoblastic nephroma 10.3 KIT MKI67
42 spindle cell sarcoma 10.3 ACTC1 DES
43 breast cancer 10.3
44 pseudosarcomatous fibromatosis 10.3 ACTC1 DES
45 familial isolated dilated cardiomyopathy 10.3 ACTC1 DES
46 chondromyxoid fibroma 10.3 ACTC1 DES
47 papillary adenocarcinoma 10.3 PGR TP53
48 malignant leydig cell tumor 10.3 KIT MME
49 chickenpox 10.3 ACTC1 PGR
50 primary peritoneal carcinoma 10.3 PGR TP53

Graphical network of the top 20 diseases related to Adenosarcoma:



Diseases related to Adenosarcoma

Symptoms & Phenotypes for Adenosarcoma

MGI Mouse Phenotypes related to Adenosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ACTC1 DES ESR1 KIT MB PGR
2 cellular MP:0005384 9.87 ACTC1 DES ESR1 KIT MB PGR
3 homeostasis/metabolism MP:0005376 9.86 ACTC1 DES ESR1 KIT MB MME
4 muscle MP:0005369 9.7 ACTC1 DES ESR1 KIT MB PGR
5 no phenotypic analysis MP:0003012 9.35 ESR1 KIT MKI67 PGR TP53
6 normal MP:0002873 9.1 ACTC1 ESR1 KIT MKI67 PGR TP53

Drugs & Therapeutics for Adenosarcoma

Drugs for Adenosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ipilimumab Approved Phase 2 477202-00-9
2
nivolumab Approved Phase 2 946414-94-4
3
Fulvestrant Approved, Investigational Phase 2 129453-61-8 17756771 104741
4
Acetaminophen Approved Phase 2 103-90-2 1983
5
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
6
Entinostat Investigational Phase 2 209783-80-2
7 Histone Deacetylase Inhibitors Phase 2,Phase 1
8 Immunoglobulins Phase 2,Phase 1
9 Antibodies Phase 2,Phase 1
10 Antineoplastic Agents, Immunological Phase 2,Phase 1
11 Antibodies, Monoclonal Phase 2,Phase 1
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
13 Hormone Antagonists Phase 2
14 Estrogen Antagonists Phase 2
15 Estrogens Phase 2
16 Estrogen Receptor Antagonists Phase 2
17 Hormones Phase 2
18 Antineoplastic Agents, Hormonal Phase 2
19 Contraceptive Agents, Male Phase 2
20 Contraceptive Agents Phase 2
21 Contraceptives, Oral Phase 2
22
Medroxyprogesterone Phase 2 520-85-4 10631
23
Fluorouracil Approved Phase 1 51-21-8 3385
24
Belinostat Approved, Investigational Phase 1 866323-14-0
25
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
26
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
27
Bevacizumab Approved, Investigational Phase 1 216974-75-3
28 Immunologic Factors Phase 1
29 Androgens Phase 1
30 Antimetabolites Phase 1
31 Immunosuppressive Agents Phase 1
32 Antimetabolites, Antineoplastic Phase 1
33 Antineoplastic Agents, Phytogenic Phase 1
34 Angiogenesis Modulating Agents Phase 1
35 Immunoglobulin G Phase 1
36 Albumin-Bound Paclitaxel Phase 1
37 Antimitotic Agents Phase 1
38 Endothelial Growth Factors Phase 1
39 Angiogenesis Inhibitors Phase 1
40 Mitogens Phase 1
41
tannic acid Approved Not Applicable 1401-55-4
42
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
2 FUlvestrant in Gynecological Cancers That Are Potentially Hormone Sensitive: the FUCHSia Study Recruiting NCT03926936 Phase 2 Fulvestrant
3 Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer Active, not recruiting NCT03018249 Phase 2 Entinostat;Medroxyprogesterone Acetate
4 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)
5 Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00413075 Phase 1 oral belinostat
6 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Suspended NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation
7 The Effects of Moderate Exercise on Distress, Quality of Life, and Biomarkers of Angiogenesis and Chronic Stress in Ovarian Cancer Survivors Recruiting NCT03641287 Not Applicable

Search NIH Clinical Center for Adenosarcoma

Cochrane evidence based reviews: adenosarcoma

Genetic Tests for Adenosarcoma

Anatomical Context for Adenosarcoma

MalaCards organs/tissues related to Adenosarcoma:

42
Breast, Uterus, Cervix, Ovary, Kidney, Liver, Testis

Publications for Adenosarcoma

Articles related to Adenosarcoma:

(show top 50) (show all 260)
# Title Authors Year
1
Mullerian adenosarcoma (heterologous) of uterine cervix with sarcomatous overgrowth: A case report with review of the literature. ( 30706880 )
2019
2
Dedifferentiated Carcinoma of the Endometrium Associated With Low-Grade Müllerian Adenosarcoma: A Clinicopathologic Case Report Including the Immunohistochemical and Molecular Profile. ( 30908285 )
2019
3
Non-puerperal uterine inversion associated with adenosarcoma of the uterus: A case report. ( 30923682 )
2019
4
A case of a primary hepatic so-called adenosarcoma with heterotopic ossification: possibly of biliary adenofibroma origin. ( 29079182 )
2018
5
MR Imaging of an Intramural Adenosarcoma with Pathologic Correlation. ( 28529247 )
2018
6
Uterine Adenosarcoma with Sarcomatous Overgrowth: A Case Report of Aggressive Disease in a 16-Year-Old Girl and a Literature Review. ( 29317258 )
2018
7
Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review. ( 29402239 )
2018
8
Uterine adenosarcoma in Japan: Clinicopathologic features, diagnosis and management. ( 29441675 )
2018
9
A Single-Centre Experience on the Management of Adenosarcoma: A Successful Report of an Integrated Medical and Surgical Approach. ( 29977120 )
2018
10
Uterine preservation in a young patient with adenosarcoma of the uterus - Case report and review of literature. ( 29977987 )
2018
11
Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma. ( 30004077 )
2018
12
Low grade Mullerian adenosarcoma of pouch of Douglas recurring as bilateral ovarian high grade Mullerian adenosarcoma with rhabdomyosarcomatous overgrowth after 11 years. ( 30108400 )
2018
13
Clinical management of uterine cervical mullerian adenosarcoma: A clinicopathological study of six cases and review of the literature. ( 30122564 )
2018
14
Prognostic factors for uterine adenosarcoma: a review. ( 30169984 )
2018
15
Uterine Adenosarcoma. ( 30326467 )
2018
16
Imaging Description of Extragenital Müllerian Adenosarcoma: A Case Report. ( 30541177 )
2018
17
A Rare Case of Intramural Müllerian Adenosarcoma Arising from Adenomyosis of the Uterus. ( 28741605 )
2017
18
Involvement of Chromosome 8 in Müllerian Adenosarcoma. ( 26974998 )
2017
19
Reply to "Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature". ( 28034793 )
2017
20
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034795 )
2017
21
Significance of lymph node metastasis on survival of women with uterine adenosarcoma. ( 28109626 )
2017
22
Case Report of Successful Childbearing after Conservative Surgery for Cervical Mullerian Adenosarcoma. ( 28154764 )
2017
23
Endometrial adenosarcoma in the setting of a germline DICER1 mutation: A case report. ( 28459098 )
2017
24
Management of Low-Grade Cervical Müllerian Adenosarcoma in a 14-Year-Old Girl. ( 28578185 )
2017
25
Müllerian Adenosarcoma of the Urinary Bladder: Clinicopathologic and Immunohistochemical Features With Novel Genetic Aberrations. ( 28690098 )
2017
26
High-grade Müllerian Adenosarcoma: Genomic and Clinicopathologic Characterization of a Distinct Neoplasm With Prevalent TP53 Pathway Alterations and Aggressive Behavior. ( 28834809 )
2017
27
Embryo Cryopreservation Following In-Vitro Maturation for Fertility Preservation in a Woman with Mullerian Adenosarcoma: A Case Report. ( 28904505 )
2017
28
Ovarian metastasis of Müllerian adenosarcoma of the cervix with sarcomatous overgrowth. ( 29085712 )
2017
29
Polypoid adenosarcoma of uterus with chondroid differentiation: A rare diagnosis. ( 29323096 )
2017
30
Treatment of Recurrent or Metastatic Uterine Adenosarcoma. ( 29445312 )
2017
31
Mullerian adenosarcoma of the cervix with heterologous elements and sarcomatous overgrowth. ( 26722175 )
2016
32
Extensive Overgrowth of Sex Cord-Like Differentiation in Uterine Mullerian Adenosarcoma: A Rare and Challenging Entity. ( 26840033 )
2016
33
Uterine Adenosarcoma. ( 26927725 )
2016
34
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 27041653 )
2016
35
Role of dacarbazine in the treatment of recurrent mullerian adenosarcoma with sarcomatous overgrowth: Our experience. ( 27139896 )
2016
36
Genomewide copy number analysis of Müllerian adenosarcoma identified chromosomal instability in the aggressive subgroup. ( 27255164 )
2016
37
Müllerian adenosarcoma of the uterine cervix with sarcomatous overgrowth: A case report of aggressive disease in a young patient. ( 27621097 )
2016
38
Uterine Adenosarcoma: a Review. ( 27718181 )
2016
39
Submucous uterine adenosarcoma-minimally invasive treatment. ( 27769260 )
2016
40
Survival of women with Mullerian adenosarcoma: A National Cancer Data Base study. ( 27771166 )
2016
41
A Case of Solitary Brain Metastasis from Uterine Mullerian Adenosarcoma with Sarcomatous Overgrowth. ( 27867926 )
2016
42
Hemoperitoneum due to breaking uterine adenosarcoma located in the omentum. Report of a case. ( 28003568 )
2016
43
Müllerian Adenosarcoma: A Malignant Progression of Adenomyosis? Pictorial Review With Multimodality Imaging. ( 26446823 )
2015
44
Uterine polyps with features overlapping with those of Müllerian adenosarcoma: a clinicopathologic analysis of 29 cases emphasizing their likely benign nature. ( 25118811 )
2015
45
Targeted genomic analysis of Müllerian adenosarcoma. ( 25231023 )
2015
46
Juvenile granulosa cell tumor arising in ovarian adenosarcoma: an unusual form of sarcomatous overgrowth. ( 25656930 )
2015
47
Uterine adenosarcoma with omentum metastasis complicated by a rapidly progressing liver abscess. ( 26166355 )
2015
48
Advanced Mesodermal (Müllerian) Adenosarcoma of the Ovary: Metastases to the Lungs, Mouth, and Brain. ( 26844003 )
2015
49
Mullerian adenosarcoma of the uterus associated with tamoxifen treatment for breast cancer. ( 28913077 )
2015
50
Systemic therapy in advanced uterine adenosarcoma with sarcomatous overgrowth. ( 24333501 )
2014

Variations for Adenosarcoma

Expression for Adenosarcoma

Search GEO for disease gene expression data for Adenosarcoma.

Pathways for Adenosarcoma

Pathways related to Adenosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 ESR1 KIT PGR TP53
2 10.88 ESR1 TP53
3 10.72 ESR1 TP53
4 10.5 ESR1 TP53

GO Terms for Adenosarcoma

Biological processes related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.32 ACTC1 DES
2 stem cell differentiation GO:0048863 9.26 ESR1 KIT
3 positive regulation of phospholipase C activity GO:0010863 9.16 ESR1 KIT
4 replicative senescence GO:0090399 8.96 MME TP53
5 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 8.62 ESR1 TP53

Molecular functions related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
2 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Adenosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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