MCID: ADN020
MIFTS: 42

Adenosarcoma

Categories: Cancer diseases

Aliases & Classifications for Adenosarcoma

MalaCards integrated aliases for Adenosarcoma:

Name: Adenosarcoma 12 55 44 15 73
Mullerian Adenosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1974
MeSH 44 D018195
NCIt 50 C9474
SNOMED-CT 68 31470003
UMLS 73 C0001442

Summaries for Adenosarcoma

Disease Ontology : 12 A carcinosarcoma that derives from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

MalaCards based summary : Adenosarcoma, also known as mullerian adenosarcoma, is related to adenomyosis and cystadenoma. An important gene associated with Adenosarcoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Gastric cancer and B Cell Development Pathways. The drugs Nivolumab and Medroxyprogesterone acetate have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and ovary, and related phenotypes are Decreased viability in esophageal squamous lineage and cardiovascular system

Related Diseases for Adenosarcoma

Diseases related to Adenosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)
# Related Disease Score Top Affiliating Genes
1 adenomyosis 30.3 ESR1 MME PGR
2 cystadenoma 30.0 MME PGR
3 rhabdomyosarcoma 29.8 DES MB TP53
4 smooth muscle tumor 29.6 DES ESR1 KIT PGR
5 carcinosarcoma 29.6 DES KIT MME PGR TP53
6 uterine carcinosarcoma 29.6 KIT MME PGR TP53
7 gastrointestinal stromal tumor 29.5 DES KIT MKI67 TP53
8 endometrial adenocarcinoma 29.4 ESR1 MKI67 PGR TP53
9 adenosarcoma of the uterus 12.6
10 ovarian mesodermal adenosarcoma 12.4
11 uterine corpus adenosarcoma 12.3
12 cervical adenosarcoma 12.3
13 vaginal adenosarcoma 12.2
14 fallopian tube adenosarcoma 12.1
15 adenosarcoma of the cervix uteri 12.1
16 adenosarcoma of the corpus uteri 12.0
17 wilms tumor 6 11.2
18 blastema predominant kidney wilms' tumor 11.0
19 epithelial predominant wilms' tumor 11.0
20 endometriosis 10.6
21 breast cancer 10.3
22 spindle cell carcinoma 10.2 DES PGR
23 renal oncocytoma 10.2 KIT MME
24 ovarian brenner tumor 10.2 KIT MME
25 adenofibroma 10.2
26 neurilemmoma 10.2 DES KIT
27 myxoid leiomyosarcoma 10.2 MME PGR
28 lymphangiomatosis 10.2 DES PGR
29 epulis 10.2 DES PGR
30 dysgerminoma of ovary 10.2 KIT PGR
31 benign metastasizing leiomyoma 10.2 DES PGR
32 malignant fibroxanthoma 10.2 DES MKI67
33 ovarian fibrothecoma 10.2 DES KIT
34 gallbladder sarcoma 10.2 DES KIT
35 malignant leydig cell tumor 10.2 KIT MME
36 rete testis adenocarcinoma 10.2 KIT MME
37 endometrial stromal nodule 10.2 MME PGR
38 meningioma, radiation-induced 10.2 MKI67 PGR
39 leiomyoma, uterine 10.2 ESR1 PGR
40 breast myofibroblastoma 10.2 ESR1 MME
41 reproductive organ benign neoplasm 10.2 ESR1 PGR
42 estrogen-receptor negative breast cancer 10.2 ESR1 PGR
43 gynecomastia 10.2 ESR1 PGR
44 tubular adenocarcinoma 10.2 ESR1 PGR
45 spermatocele 10.2 MME PGR
46 syringoma 10.2 DES ESR1
47 leiomyomatosis 10.2 ESR1 PGR
48 mature b-cell neoplasm 10.1 MME TP53
49 vestibular gland benign neoplasm 10.1 ESR1 PGR
50 adenomyoma 10.1

Graphical network of the top 20 diseases related to Adenosarcoma:



Diseases related to Adenosarcoma

Symptoms & Phenotypes for Adenosarcoma

GenomeRNAi Phenotypes related to Adenosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.1 DES ESR1 KIT MB PGR TP53

MGI Mouse Phenotypes related to Adenosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 DES ESR1 KIT MB PGR TP53
2 homeostasis/metabolism MP:0005376 9.8 DES ESR1 KIT MB MME PGR
3 embryo MP:0005380 9.72 ESR1 KIT MB PGR TP53
4 integument MP:0010771 9.55 ESR1 KIT MME PGR TP53
5 muscle MP:0005369 9.43 DES ESR1 KIT MB PGR TP53
6 no phenotypic analysis MP:0003012 9.02 ESR1 KIT MKI67 PGR TP53

Drugs & Therapeutics for Adenosarcoma

Drugs for Adenosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
3
Acetaminophen Approved Phase 2 103-90-2 1983
4
Entinostat Investigational Phase 2 209783-80-2
5 Immunologic Factors Phase 2,Phase 1
6 Histone Deacetylase Inhibitors Phase 2,Phase 1
7 Immunoglobulins Phase 2,Phase 1
8 Antibodies, Monoclonal Phase 2,Phase 1
9 Antibodies Phase 2,Phase 1
10 Contraceptive Agents, Male Phase 2
11 Contraceptives, Oral Phase 2
12
Medroxyprogesterone Phase 2 520-85-4 10631
13 Antineoplastic Agents, Hormonal Phase 2
14 Contraceptive Agents Phase 2
15
Fluorouracil Approved Phase 1 51-21-8 3385
16
Belinostat Approved, Investigational Phase 1 866323-14-0
17
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
18
Bevacizumab Approved, Investigational Phase 1 216974-75-3
19 Androgens Phase 1
20 Antimetabolites, Antineoplastic Phase 1
21 Immunosuppressive Agents Phase 1
22 Antimetabolites Phase 1
23 Antineoplastic Agents, Phytogenic Phase 1
24 Angiogenesis Modulating Agents Phase 1
25 Antimitotic Agents Phase 1
26 Endothelial Growth Factors Phase 1
27 Immunoglobulin G Phase 1
28 Angiogenesis Inhibitors Phase 1
29 Albumin-Bound Paclitaxel Phase 1
30 Mitogens Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
2 Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer Active, not recruiting NCT03018249 Phase 2 Entinostat;Medroxyprogesterone Acetate
3 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)
4 Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00413075 Phase 1 oral belinostat
5 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Recruiting NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation
6 The Effects of Moderate Exercise on Distress, Quality of Life, and Biomarkers of Angiogenesis and Chronic Stress in Ovarian Cancer Survivors Recruiting NCT03641287 Not Applicable

Search NIH Clinical Center for Adenosarcoma

Cochrane evidence based reviews: adenosarcoma

Genetic Tests for Adenosarcoma

Anatomical Context for Adenosarcoma

MalaCards organs/tissues related to Adenosarcoma:

41
Uterus, Cervix, Ovary, Breast, Prostate, Brain, Testis

Publications for Adenosarcoma

Articles related to Adenosarcoma:

(show top 50) (show all 257)
# Title Authors Year
1
A Single-Centre Experience on the Management of Adenosarcoma: A Successful Report of an Integrated Medical and Surgical Approach. ( 29977120 )
2018
2
Uterine preservation in a young patient with adenosarcoma of the uterus - Case report and review of literature. ( 29977987 )
2018
3
Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review. ( 29402239 )
2018
4
Uterine adenosarcoma with sarcomatous overgrowth: A case report of aggressive disease in a 16-year-old girl and a literature review. ( 29317258 )
2018
5
Uterine adenosarcoma in Japan: Clinicopathologic features, diagnosis and management. ( 29441675 )
2018
6
Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma. ( 30004077 )
2018
7
Low grade Mullerian adenosarcoma of pouch of Douglas recurring as bilateral ovarian high grade Mullerian adenosarcoma with rhabdomyosarcomatous overgrowth after 11 years. ( 30108400 )
2018
8
Clinical management of uterine cervical mullerian adenosarcoma: A clinicopathological study of six cases and review of the literature. ( 30122564 )
2018
9
Prognostic factors for uterine adenosarcoma: a review. ( 30169984 )
2018
10
Uterine Adenosarcoma. ( 30326467 )
2018
11
Imaging Description of Extragenital Müllerian Adenosarcoma: A Case Report. ( 30541177 )
2018
12
Polypoid adenosarcoma of uterus with chondroid differentiation: A rare diagnosis. ( 29323096 )
2017
13
Ovarian metastasis of MA1llerian adenosarcoma of the cervix with sarcomatous overgrowth. ( 29085712 )
2017
14
A case of a primary hepatic so-called adenosarcoma with heterotopic ossification: possibly of biliary adenofibroma origin. ( 29079182 )
2017
15
MA1llerian Adenosarcoma of the Urinary Bladder: Clinicopathologic and Immunohistochemical Features With Novel Genetic Aberrations. ( 28690098 )
2017
16
Endometrial adenosarcoma in the setting of a germline DICER1 mutation: A case report. ( 28459098 )
2017
17
A Rare Case of Intramural MA1llerian Adenosarcoma Arising from Adenomyosis of the Uterus. ( 28741605 )
2017
18
Management of Low-Grade Cervical MA1llerian Adenosarcoma in a 14-Year-Old Girl. ( 28578185 )
2017
19
Treatment of Recurrent or Metastatic Uterine Adenosarcoma. ( 29445312 )
2017
20
Case Report of Successful Childbearing after Conservative Surgery for Cervical Mullerian Adenosarcoma. ( 28154764 )
2017
21
Significance of lymph node metastasis on survival of women with uterine adenosarcoma. ( 28109626 )
2017
22
MR Imaging of an Intramural Adenosarcoma with Pathologic Correlation. ( 28529247 )
2017
23
Embryo Cryopreservation Following In-Vitro Maturation for Fertility Preservation in a Woman with Mullerian Adenosarcoma: A Case Report. ( 28904505 )
2017
24
High-grade MA1llerian Adenosarcoma: Genomic and Clinicopathologic Characterization of a Distinct Neoplasm With Prevalent TP53 Pathway Alterations and Aggressive Behavior. ( 28834809 )
2017
25
A Case of Solitary Brain Metastasis from Uterine Mullerian Adenosarcoma with Sarcomatous Overgrowth. ( 27867926 )
2016
26
Submucous uterine adenosarcoma-minimally invasive treatment. ( 27769260 )
2016
27
Role of dacarbazine in the treatment of recurrent mullerian adenosarcoma with sarcomatous overgrowth: Our experience. ( 27139896 )
2016
28
Mullerian adenosarcoma of the cervix with heterologous elements and sarcomatous overgrowth. ( 26722175 )
2016
29
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034793 )
2016
30
Survival of women with Mullerian adenosarcoma: A National Cancer Data Base study. ( 27771166 )
2016
31
Uterine Adenosarcoma. ( 26927725 )
2016
32
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 27041653 )
2016
33
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034795 )
2016
34
Uterine Adenosarcoma: a Review. ( 27718181 )
2016
35
MA1llerian adenosarcoma of the uterine cervix with sarcomatous overgrowth: A case report of aggressive disease in a young patient. ( 27621097 )
2016
36
Involvement of Chromosome 8 in MA1llerian Adenosarcoma. ( 26974998 )
2016
37
Hemoperitoneum due to breaking uterine adenosarcoma located in the omentum. Report of a case. ( 28003568 )
2016
38
Extensive Overgrowth of Sex Cord-Like Differentiation in Uterine Mullerian Adenosarcoma: A Rare and Challenging Entity. ( 26840033 )
2016
39
Genomewide copy number analysis of MA1llerian adenosarcoma identified chromosomal instability in the aggressive subgroup. ( 27255164 )
2016
40
Juvenile granulosa cell tumor arising in ovarian adenosarcoma: an unusual form of sarcomatous overgrowth. ( 25656930 )
2015
41
Advanced Mesodermal (MA1llerian) Adenosarcoma of the Ovary: Metastases to the Lungs, Mouth, and Brain. ( 26844003 )
2015
42
Uterine adenosarcoma with omentum metastasis complicated by a rapidly progressing liver abscess. ( 26166355 )
2015
43
Mullerian adenosarcoma of the uterus associated with tamoxifen treatment for breast cancer. ( 28913077 )
2015
44
MA1llerian Adenosarcoma: A Malignant Progression of Adenomyosis? Pictorial Review With Multimodality Imaging. ( 26446823 )
2015
45
Extrauterine adenosarcoma arising in omental endometriosis: Rare site of occurrence of a rare tumor. ( 25308029 )
2014
46
Extragenital mA1llerian adenosarcoma in the pouch of douglas. ( 25207177 )
2014
47
MA1llerian adenosarcoma: a review of cases and literature. ( 25556263 )
2014
48
Targeted genomic analysis of MA1llerian adenosarcoma. ( 25231023 )
2014
49
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. ( 25272296 )
2014
50
Metanephric adenosarcoma: a rare case with immunohistochemistry and molecular analysis. ( 25267074 )
2014

Variations for Adenosarcoma

Expression for Adenosarcoma

Search GEO for disease gene expression data for Adenosarcoma.

Pathways for Adenosarcoma

Pathways related to Adenosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 ESR1 KIT PGR TP53
2 11.05 KIT MME
3 10.88 ESR1 TP53
4 10.72 ESR1 TP53
5 10.5 ESR1 TP53

GO Terms for Adenosarcoma

Biological processes related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone mediated signaling pathway GO:0043401 9.32 ESR1 PGR
2 stem cell differentiation GO:0048863 9.26 ESR1 KIT
3 positive regulation of phospholipase C activity GO:0010863 9.16 ESR1 KIT
4 replicative senescence GO:0090399 8.96 MME TP53
5 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 8.62 ESR1 TP53

Molecular functions related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.26 ESR1 PGR
2 zinc ion binding GO:0008270 9.26 ESR1 MME PGR TP53
3 nuclear receptor activity GO:0004879 9.16 ESR1 PGR
4 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Adenosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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