MCID: ADN020
MIFTS: 41

Adenosarcoma

Categories: Cancer diseases, Nephrological diseases, Reproductive diseases

Aliases & Classifications for Adenosarcoma

MalaCards integrated aliases for Adenosarcoma:

Name: Adenosarcoma 12 54 44 15 17 70
Mullerian Adenosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1974
MeSH 44 D018195
NCIt 50 C9474
SNOMED-CT 67 189804002
UMLS 70 C0001442

Summaries for Adenosarcoma

Disease Ontology : 12 A carcinosarcoma that derives from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

MalaCards based summary : Adenosarcoma, also known as mullerian adenosarcoma, is related to uterine corpus adenosarcoma and cervical adenosarcoma. An important gene associated with Adenosarcoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Gastric cancer and Signaling by ERBB4. The drugs Fulvestrant and Hormones have been mentioned in the context of this disorder. Affiliated tissues include breast, uterus and cervix, and related phenotypes are cardiovascular system and cellular

Wikipedia : 73 Adenosarcoma (also Mullerian Adenosarcoma) is a rare malignant tumor that occurs in women of all age... more...

Related Diseases for Adenosarcoma

Diseases related to Adenosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 441)
# Related Disease Score Top Affiliating Genes
1 uterine corpus adenosarcoma 32.4 PGR MME ESR1
2 cervical adenosarcoma 31.5 TP53 PGR MME JAZF1 ESR1
3 rare tumor 30.9 KIT DES ACTC1
4 cervical polyp 30.8 PGR MME DES
5 adenomyoma 30.7 PGR MME
6 cystadenofibroma 30.6 TP53 MME
7 embryonal rhabdomyosarcoma 30.4 TP53 MB DES
8 adenofibroma 30.4 VIM TP53 MME ACTC1
9 adenomyosis 30.4 TP53 PGR MME ESR1
10 pleuropulmonary blastoma 30.3 TP53 MB DES
11 angiosarcoma 30.1 VIM TP53 KIT
12 botryoid rhabdomyosarcoma 30.1 MB DES ACTC1
13 endometrial adenocarcinoma 29.9 TP53 PGR ESR1 ERBB2
14 ovarian fibrothecoma 29.9 KIT DES ACTC1
15 wilms tumor 1 29.8 VIM TP53 SERPINA3 PGR MME ESR1
16 endometrial hyperplasia 29.8 TP53 PGR MKI67 ESR1
17 teratoma 29.8 TP53 KIT ACTC1
18 cellular leiomyoma 29.8 MME JAZF1 DES
19 cystadenoma 29.6 SERPINA3 PGR MME
20 mesenchymal cell neoplasm 29.6 TP53 SERPINA3 MME KIT
21 uterine carcinosarcoma 29.6 TP53 PGR MME KIT ERBB2
22 ovarian disease 29.6 TP53 PGR ESR1 ERBB2
23 fibrosarcoma 29.6 VIM TP53 KIT DES ACTC1
24 pleomorphic rhabdomyosarcoma 29.5 TP53 MME MB ACTC1
25 myofibroma 29.5 SERPINA3 MB DES
26 spindle cell sarcoma 29.3 VIM SERPINA3 KIT DES ACTC1
27 ovarian serous cystadenocarcinoma 29.3 TP53 SERPINA3 PGR ERBB2
28 embryonal sarcoma 29.3 VIM TP53 SERPINA3 MKI67 KIT DES
29 endometrial stromal tumor 29.2 PHF1 PGR MME JAZF1 ESR1
30 leiomyoma 29.1 VIM PGR MME MKI67 KIT ESR1
31 carcinosarcoma 29.1 VIM TP53 PGR MME MB KIT
32 rhabdomyosarcoma 29.1 VIM TP53 MME MB KIT ESR1
33 inflammatory myofibroblastic tumor 29.1 VIM TP53 MKI67 KIT DES ACTC1
34 breast adenocarcinoma 29.0 TP53 SERPINA3 PGR ESR1 ERBB2
35 endometrial cancer 28.8 TP53 SERPINA3 PGR MME MKI67 ESR1
36 gastrointestinal stromal tumor 28.8 VIM TP53 MKI67 KIT ERBB2 DES
37 leiomyosarcoma 28.3 VIM TP53 SERPINA3 PGR MB KIT
38 smooth muscle tumor 28.1 VIM SERPINA3 PGR MME KIT ESR1
39 endometrial stromal sarcoma 27.9 VIM TP53 PHF1 PGR MME MB
40 adenosarcoma of the uterus 11.6
41 fallopian tube adenosarcoma 11.2
42 ovarian mesodermal adenosarcoma 11.2
43 vaginal adenosarcoma 11.2
44 adenosarcoma of the cervix uteri 11.2
45 blastema predominant kidney wilms' tumor 10.9
46 epithelial predominant wilms' tumor 10.9
47 adenosarcoma of the corpus uteri 10.9
48 overgrowth syndrome 10.7
49 endometriosis 10.6
50 cervical adenomyoma 10.4 PGR MME

Graphical network of the top 20 diseases related to Adenosarcoma:



Diseases related to Adenosarcoma

Symptoms & Phenotypes for Adenosarcoma

MGI Mouse Phenotypes related to Adenosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ACTC1 BCOR DES ERBB2 ESR1 KIT
2 cellular MP:0005384 10.06 ACTC1 BCOR DES ERBB2 ESR1 KIT
3 embryo MP:0005380 9.91 ACTC1 BCOR ERBB2 ESR1 KIT MB
4 homeostasis/metabolism MP:0005376 9.9 ACTC1 DES ERBB2 ESR1 KIT MB
5 muscle MP:0005369 9.61 ACTC1 DES ERBB2 ESR1 KIT MB
6 normal MP:0002873 9.23 ACTC1 ERBB2 ESR1 KIT MKI67 PGR

Drugs & Therapeutics for Adenosarcoma

Drugs for Adenosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
2 Hormones Phase 2
3 Estrogen Receptor Antagonists Phase 2
4 Hormone Antagonists Phase 2
5 Estrogen Antagonists Phase 2
6 Antineoplastic Agents, Hormonal Phase 2
7 Estrogens Phase 2
8
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
9
Bevacizumab Approved, Investigational Phase 1 216974-75-3
10 Antineoplastic Agents, Immunological Phase 1
11 Immunoglobulin G Phase 1
12 Angiogenesis Inhibitors Phase 1
13 Immunoglobulins Phase 1
14 Albumin-Bound Paclitaxel Phase 1
15 Antimitotic Agents Phase 1
16 Mitogens Phase 1
17 Tubulin Modulators Phase 1
18 Immunologic Factors Phase 1
19 Endothelial Growth Factors Phase 1
20 Immunoglobulins, Intravenous Phase 1
21 Antibodies Phase 1
22 Antibodies, Monoclonal Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-label, Single Arm, Prospective, Multi-center, Tandem Two Stage Designed, Phase II Study to Evaluate the Efficacy of Fulvestrant in Women With Recurrent/Metastatic Estrogen Receptor Positive Gynecological Malignancies Recruiting NCT03926936 Phase 2 Fulvestrant
2 Targeted Complex Therapy for Advanced Melanoma, Gynecologic Cancers, and Other Malignancies: Nab-Paclitaxel (Abraxane)/Bevacizumab Complex (AB-Complex) Suspended NCT02020707 Phase 1 Nab-paclitaxel

Search NIH Clinical Center for Adenosarcoma

Cochrane evidence based reviews: adenosarcoma

Genetic Tests for Adenosarcoma

Anatomical Context for Adenosarcoma

MalaCards organs/tissues related to Adenosarcoma:

40
Breast, Uterus, Cervix, Ovary, Liver, Kidney, Smooth Muscle

Publications for Adenosarcoma

Articles related to Adenosarcoma:

(show top 50) (show all 513)
# Title Authors PMID Year
1
Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. 61 54
18941402 2009
2
CD10, estrogen and progesterone receptor expression in ovarian adenosarcoma. 61 54
16051333 2005
3
Immunohistochemical expression of CD10 antigen in uterine adenosarcoma. 61 54
15571618 2004
4
Immunohistochemical determination of estrogen and progesterone receptor positivity in uterine adenosarcoma. 61 54
15196864 2004
5
Expression of CD10 in malignant müllerian mixed tumors and adenosarcomas: an immunohistochemical study. 61 54
12218209 2002
6
Adenosarcoma of the uterine corpus associated with ovarian thecoma. 54 61
11696179 2001
7
Uterine angiosarcomas: a morphologic and immunohistochemical study of four cases. 61 54
9500227 1998
8
SATB2 Expression in Uterine Sarcoma: A Multicenter Retrospective Study. 61
33720083 2021
9
Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma. 61
33370472 2021
10
Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma. 61
33565764 2021
11
Primary Fallopian Tube Mullerian Adenosarcoma With Sarcomatous Overgrowth and a Previously Unreported MEIS1-NCOA2 Gene Fusion. 61
33770059 2021
12
DICER1-associated embryonal rhabdomyosarcoma and adenosarcoma of the gynecologic tract: Pathology, molecular genetics, and indications for molecular testing. 61
33135284 2021
13
Müllerian Adenosarcoma: A Single-Centre Experience of 59 Cases of This Rare Entity. 61
33747657 2021
14
Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual patient report for 2017 and annual treatment report for 2012. 61
33631867 2021
15
The mutational repertoire of uterine sarcomas and carcinosarcomas in a Brazilian cohort: A preliminary study. 61
33503190 2021
16
Fertility sparing management of uterine adenosarcoma: Case report and literature review. 61
33575681 2021
17
Post-radiation Mullerian adenosarcoma with sarcomatous overgrowth: rare presentation of an uncommon malignancy. 61
33393526 2020
18
Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases. 61
33093955 2020
19
Does iatrogenic tumor rupture during surgery have prognostic implications for the outcome of uterine sarcomas? 61
32948637 2020
20
MRI findings characteristic of ovarian primary adenosarcoma. 61
31775546 2020
21
Italian consensus conference on management of uterine sarcomas on behalf of S.I.G.O. (Societa' italiana di Ginecologia E Ostetricia). 61
32992154 2020
22
Uterine cervix rhabdomyosarcoma: an uncommon entity in an adult patient. 61
33257391 2020
23
A randomized double-blind phase II study evaluating the role of maintenance therapy with cabozantinib in high-grade uterine sarcoma after stabilization or response to doxorubicin ± ifosfamide following surgery or in metastatic first line treatment (EORTC62113). 61
32546554 2020
24
Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis. 61
31855579 2020
25
Uterine Adenosarcoma Originating in Adenomyosis: Report of an Extremely Rare Phenomenon and Review of Published Literature. 61
32947330 2020
26
Primary biliary adenosarcoma of the liver-a special and new entity. 61
32219513 2020
27
Immunohistochemical markers and the clinical course of adenosarcoma: a series of seven cases. 61
32972432 2020
28
Superior Vena Cava Syndrome associated with recurrent uterine adenosarcoma. 61
32760777 2020
29
Malignant extra-ovarian endometriosis: A case series of ten patients and review of the literature. 61
32452019 2020
30
NTRK fusion cervical sarcoma: a report of three cases, emphasising morphological and immunohistochemical distinction from other uterine sarcomas, including adenosarcoma. 61
31971278 2020
31
Significantly greater prevalence of DICER1 alterations in uterine embryonal rhabdomyosarcoma compared to adenosarcoma. 61
31900434 2020
32
BCOR Expression in Mullerian Adenosarcoma: A Potential Diagnostic Pitfall. 61
32011345 2020
33
Management and survival of patients with Mullerian adenosarcoma of the cervix without sarcomatous overgrowth desiring fertility preservation, a case report and review of the literature. 61
32181315 2020
34
Primary sarcoma of the cervix: an analysis of patient and tumor characteristics, treatment patterns, and outcomes. 61
31912680 2020
35
Dedifferentiated Carcinoma of the Endometrium Associated With Low-grade Müllerian Adenosarcoma: A Clinicopathologic Case Report Including the Immunohistochemical and Molecular Profile. 61
30908285 2020
36
Development and Validation of a Personalized Survival Prediction Model for Uterine Adenosarcoma: A Population-Based Deep Learning Study. 61
33680946 2020
37
Whole-Genome Sequencing and Target Validation Analysis of Müllerian Adenosarcoma: A Tumor With Complex but Specific Genetic Alterations. 61
32351899 2020
38
A Real-World Study on Diagnosis and Treatment of Uterine Sarcoma in Western China. 61
32015676 2020
39
A case of three rare uterine neoplasms in the same surgical specimen. 61
32129176 2020
40
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature. 61
30617760 2020
41
The immune microenvironment of uterine adenosarcomas. 61
32231779 2020
42
Ultrasound Features of Uterine Sarcomas. 61
31094892 2019
43
Hormonal therapies in uterine sarcomas, aggressive angiomyxoma, and desmoid-type fibromatosis. 61
31494310 2019
44
Conservative management of uterine adenosarcoma: lessons learned from 20 years of follow-up. 61
31584132 2019
45
Advanced uterine adenosarcoma with sarcomatous overgrowth in a young woman: A case report. 61
31764852 2019
46
Uterine lesions with sex cord-like architectures: a systematic review. 61
31739799 2019
47
Diagnostic challenges: low-grade adenosarcoma on deep endometriosis. 61
31655582 2019
48
Endometriosis Malignant Transformation Review: Rhabdomyosarcoma Arising From an Endometrioma. 61
31624455 2019
49
SATB2 is Consistently Expressed in Squamous Morules Associated With Endometrioid Proliferative Lesions and in the Stroma of Atypical Polypoid Adenomyoma. 61
30085940 2019
50
Uterine and Cervical Adenosarcoma: A Retrospective Study of Overall Oncologic Outcomes and Fertility Preservation in Early-Stage Disease. 61
31127022 2019

Variations for Adenosarcoma

Expression for Adenosarcoma

Search GEO for disease gene expression data for Adenosarcoma.

Pathways for Adenosarcoma

GO Terms for Adenosarcoma

Biological processes related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 9.43 VIM DES
2 replicative senescence GO:0090399 9.4 TP53 MME
3 positive regulation of phospholipase C activity GO:0010863 9.37 KIT ESR1
4 positive regulation of gene expression GO:0010628 9.35 VIM TP53 KIT ERBB2 ACTC1
5 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.32 TP53 ESR1
6 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.26 TP53 ESR1
7 intracellular steroid hormone receptor signaling pathway GO:0030518 9.16 PGR ESR1
8 muscle filament sliding GO:0030049 8.8 VIM DES ACTC1

Molecular functions related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 VIM TP53 PHF1 PGR ESR1 ERBB2
2 RNA polymerase II transcription corepressor binding GO:0001226 8.96 PHF1 ESR1

Sources for Adenosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....