Aliases & Classifications for Adenosarcoma

MalaCards integrated aliases for Adenosarcoma:

Name: Adenosarcoma 12 55 44 15 73
Mullerian Adenosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1974
MeSH 44 D018195
NCIt 50 C9474
SNOMED-CT 68 189804002 31470003
UMLS 73 C0001442

Summaries for Adenosarcoma

Disease Ontology : 12 A carcinosarcoma that derives from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

MalaCards based summary : Adenosarcoma, also known as mullerian adenosarcoma, is related to adenomyosis and malignant mixed mullerian tumor. An important gene associated with Adenosarcoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Gastric cancer and B Cell Development Pathways. The drugs nivolumab and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and ovary, and related phenotypes are Decreased viability in esophageal squamous lineage and cardiovascular system

Wikipedia : 76 Adenosarcoma is an uncommon form of cancer that arises from mesenchymal tissue and has a benign... more...

Related Diseases for Adenosarcoma

Diseases related to Adenosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 adenomyosis 30.7 ESR1 PGR
2 malignant mixed mullerian tumor 30.4 KIT PGR
3 cystadenoma 30.3 MME PGR
4 smooth muscle tumor 28.9 DES ESR1 KIT PGR
5 rhabdomyosarcoma 28.8 DES MB TP53
6 uterine carcinosarcoma 28.8 KIT MME PGR TP53
7 gastrointestinal stromal tumor 28.5 DES KIT MKI67 TP53
8 endometrial adenocarcinoma 28.3 ESR1 MKI67 PGR TP53
9 uterine sarcoma 27.5 DES ESR1 KIT MB MME
10 adenosarcoma of the uterus 12.4
11 ovarian mesodermal adenosarcoma 12.3
12 uterine corpus adenosarcoma 12.2
13 cervical adenosarcoma 12.1
14 vaginal adenosarcoma 12.1
15 fallopian tube adenosarcoma 11.9
16 adenosarcoma of the cervix uteri 11.9
17 adenosarcoma of the corpus uteri 11.8
18 blastema predominant kidney wilms' tumor 10.9
19 epithelial predominant wilms' tumor 10.9
20 lymphangiomatosis 10.6 DES PGR
21 epulis 10.6 DES PGR
22 benign metastasizing leiomyoma 10.6 DES PGR
23 endometrial stromal nodule 10.6 MME PGR
24 ovarian fibrothecoma 10.6 DES KIT
25 malignant leydig cell tumor 10.6 KIT MME
26 gallbladder sarcoma 10.6 DES KIT
27 spermatocele 10.6 MME PGR
28 rete testis adenocarcinoma 10.6 KIT MME
29 kidney benign neoplasm 10.6 KIT MME
30 breast myofibroblastoma 10.6 ESR1 MME
31 rete testis neoplasm 10.5 KIT MME
32 congenital epulis 10.5 DES PGR
33 breast angiosarcoma 10.5 KIT PGR
34 myxofibrosarcoma 10.5 DES MKI67
35 vulvar syringoma 10.5 ESR1 PGR
36 lung leiomyoma 10.5 ESR1 PGR
37 glassy cell carcinoma of the cervix 10.5 ESR1 PGR
38 vulvar benign neoplasm 10.5 ESR1 PGR
39 trigonitis 10.5 ESR1 PGR
40 vulvar leiomyoma 10.5 ESR1 PGR
41 predominantly cortical thymoma 10.5 ESR1 PGR
42 syringoma 10.5 DES ESR1
43 breast medullary carcinoma 10.5 ESR1 PGR
44 breast scirrhous carcinoma 10.5 ESR1 PGR
45 progesterone resistance 10.5 ESR1 PGR
46 progesterone-receptor positive breast cancer 10.5 ESR1 PGR
47 oncocytic breast carcinoma 10.5 ESR1 PGR
48 endometrial squamous cell carcinoma 10.4 ESR1 PGR
49 dermoid cyst 10.4 KIT PGR
50 gastric signet ring cell adenocarcinoma 10.4 ESR1 PGR

Graphical network of the top 20 diseases related to Adenosarcoma:



Diseases related to Adenosarcoma

Symptoms & Phenotypes for Adenosarcoma

GenomeRNAi Phenotypes related to Adenosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.1 DES ESR1 KIT MB PGR TP53

MGI Mouse Phenotypes related to Adenosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 KIT MB PGR DES TP53 ESR1
2 homeostasis/metabolism MP:0005376 9.8 KIT MB MME PGR DES TP53
3 embryo MP:0005380 9.72 KIT MB PGR TP53 ESR1
4 integument MP:0010771 9.55 KIT MME PGR TP53 ESR1
5 muscle MP:0005369 9.43 MB PGR TP53 DES ESR1 KIT
6 no phenotypic analysis MP:0003012 9.02 KIT MKI67 PGR TP53 ESR1

Drugs & Therapeutics for Adenosarcoma

Drugs for Adenosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Acetaminophen Approved Phase 2 103-90-2 1983
3
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
4
Entinostat Investigational Phase 2 209783-80-2
5 Histone Deacetylase Inhibitors Phase 2,Phase 1
6 Antibodies Phase 2,Phase 1
7 Antibodies, Monoclonal Phase 2,Phase 1
8 Immunoglobulins Phase 2,Phase 1
9 Antineoplastic Agents, Hormonal Phase 2
10 Contraceptive Agents Phase 2
11 Contraceptive Agents, Male Phase 2
12 Contraceptives, Oral Phase 2
13
Medroxyprogesterone Phase 2 520-85-4 10631
14
Belinostat Approved, Investigational Phase 1 866323-14-0
15
Fluorouracil Approved Phase 1 51-21-8 3385
16
Bevacizumab Approved, Investigational Phase 1 216974-75-3
17
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
18 Androgens Phase 1
19 Antimetabolites Phase 1
20 Antimetabolites, Antineoplastic Phase 1
21 Immunosuppressive Agents Phase 1
22 Albumin-Bound Paclitaxel Phase 1
23 Angiogenesis Inhibitors Phase 1
24 Angiogenesis Modulating Agents Phase 1
25 Antimitotic Agents Phase 1
26 Antineoplastic Agents, Phytogenic Phase 1
27 Endothelial Growth Factors Phase 1
28 Immunoglobulin G Phase 1
29 Mitogens Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
2 Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer Active, not recruiting NCT03018249 Phase 2 Entinostat;Medroxyprogesterone Acetate
3 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)
4 Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00413075 Phase 1 oral belinostat
5 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Suspended NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation

Search NIH Clinical Center for Adenosarcoma

Cochrane evidence based reviews: adenosarcoma

Genetic Tests for Adenosarcoma

Anatomical Context for Adenosarcoma

MalaCards organs/tissues related to Adenosarcoma:

41
Uterus, Cervix, Ovary, Breast, Endothelial, Lung, Brain

Publications for Adenosarcoma

Articles related to Adenosarcoma:

(show top 50) (show all 250)
# Title Authors Year
1
A Single-Centre Experience on the Management of Adenosarcoma: A Successful Report of an Integrated Medical and Surgical Approach. ( 29977120 )
2018
2
Uterine preservation in a young patient with adenosarcoma of the uterus - Case report and review of literature. ( 29977987 )
2018
3
Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review. ( 29402239 )
2018
4
Uterine adenosarcoma with sarcomatous overgrowth: A case report of aggressive disease in a 16-year-old girl and a literature review. ( 29317258 )
2018
5
Uterine adenosarcoma in Japan: Clinicopathologic features, diagnosis and management. ( 29441675 )
2018
6
Polypoid adenosarcoma of uterus with chondroid differentiation: A rare diagnosis. ( 29323096 )
2017
7
Ovarian metastasis of MA1llerian adenosarcoma of the cervix with sarcomatous overgrowth. ( 29085712 )
2017
8
A case of a primary hepatic so-called adenosarcoma with heterotopic ossification: possibly of biliary adenofibroma origin. ( 29079182 )
2017
9
MA1llerian Adenosarcoma of the Urinary Bladder: Clinicopathologic and Immunohistochemical Features With Novel Genetic Aberrations. ( 28690098 )
2017
10
Endometrial adenosarcoma in the setting of a germline DICER1 mutation: A case report. ( 28459098 )
2017
11
A Rare Case of Intramural MA1llerian Adenosarcoma Arising from Adenomyosis of the Uterus. ( 28741605 )
2017
12
Management of Low-Grade Cervical MA1llerian Adenosarcoma in a 14-Year-Old Girl. ( 28578185 )
2017
13
Treatment of Recurrent or Metastatic Uterine Adenosarcoma. ( 29445312 )
2017
14
Case Report of Successful Childbearing after Conservative Surgery for Cervical Mullerian Adenosarcoma. ( 28154764 )
2017
15
Significance of lymph node metastasis on survival of women with uterine adenosarcoma. ( 28109626 )
2017
16
MR Imaging of an Intramural Adenosarcoma with Pathologic Correlation. ( 28529247 )
2017
17
Embryo Cryopreservation Following In-Vitro Maturation for Fertility Preservation in a Woman with Mullerian Adenosarcoma: A Case Report. ( 28904505 )
2017
18
High-grade MA1llerian Adenosarcoma: Genomic and Clinicopathologic Characterization of a Distinct Neoplasm With Prevalent TP53 Pathway Alterations and Aggressive Behavior. ( 28834809 )
2017
19
A Case of Solitary Brain Metastasis from Uterine Mullerian Adenosarcoma with Sarcomatous Overgrowth. ( 27867926 )
2016
20
Submucous uterine adenosarcoma-minimally invasive treatment. ( 27769260 )
2016
21
Role of dacarbazine in the treatment of recurrent mullerian adenosarcoma with sarcomatous overgrowth: Our experience. ( 27139896 )
2016
22
Mullerian adenosarcoma of the cervix with heterologous elements and sarcomatous overgrowth. ( 26722175 )
2016
23
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034793 )
2016
24
Survival of women with Mullerian adenosarcoma: A National Cancer Data Base study. ( 27771166 )
2016
25
Uterine Adenosarcoma. ( 26927725 )
2016
26
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 27041653 )
2016
27
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034795 )
2016
28
Uterine Adenosarcoma: a Review. ( 27718181 )
2016
29
MA1llerian adenosarcoma of the uterine cervix with sarcomatous overgrowth: A case report of aggressive disease in a young patient. ( 27621097 )
2016
30
Involvement of Chromosome 8 in MA1llerian Adenosarcoma. ( 26974998 )
2016
31
Hemoperitoneum due to breaking uterine adenosarcoma located in the omentum. Report of a case. ( 28003568 )
2016
32
Extensive Overgrowth of Sex Cord-Like Differentiation in Uterine Mullerian Adenosarcoma: A Rare and Challenging Entity. ( 26840033 )
2016
33
Genomewide copy number analysis of MA1llerian adenosarcoma identified chromosomal instability in the aggressive subgroup. ( 27255164 )
2016
34
Juvenile granulosa cell tumor arising in ovarian adenosarcoma: an unusual form of sarcomatous overgrowth. ( 25656930 )
2015
35
Advanced Mesodermal (MA1llerian) Adenosarcoma of the Ovary: Metastases to the Lungs, Mouth, and Brain. ( 26844003 )
2015
36
Uterine adenosarcoma with omentum metastasis complicated by a rapidly progressing liver abscess. ( 26166355 )
2015
37
Mullerian adenosarcoma of the uterus associated with tamoxifen treatment for breast cancer. ( 28913077 )
2015
38
MA1llerian Adenosarcoma: A Malignant Progression of Adenomyosis? Pictorial Review With Multimodality Imaging. ( 26446823 )
2015
39
Extrauterine adenosarcoma arising in omental endometriosis: Rare site of occurrence of a rare tumor. ( 25308029 )
2014
40
Extragenital mA1llerian adenosarcoma in the pouch of douglas. ( 25207177 )
2014
41
MA1llerian adenosarcoma: a review of cases and literature. ( 25556263 )
2014
42
Targeted genomic analysis of MA1llerian adenosarcoma. ( 25231023 )
2014
43
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. ( 25272296 )
2014
44
Metanephric adenosarcoma: a rare case with immunohistochemistry and molecular analysis. ( 25267074 )
2014
45
Adenosarcoma of the uterine body initially presenting as an interstitial small tumor of the uterus: a case report. ( 25118497 )
2014
46
Mullerian adenosarcoma of the cervix: Report of two large tumors with sarcomatous overgrowth or heterologous elements. ( 25426405 )
2014
47
Uterine Polyps With Features Overlapping With Those of MA1llerian Adenosarcoma: A Clinicopathologic Analysis of 29 Cases Emphasizing Their Likely Benign Nature. ( 25118811 )
2014
48
A case of adenosarcoma of the uterus. ( 24592340 )
2014
49
Uterine adenosarcoma: an analysis on management, outcomes, and risk factors for recurrence. ( 25449308 )
2014
50
Gynecologic Cancer InterGroup (GCIG) Consensus Review for Mullerian Adenosarcoma of the Female Genital Tract. ( 25341585 )
2014

Variations for Adenosarcoma

Expression for Adenosarcoma

Search GEO for disease gene expression data for Adenosarcoma.

Pathways for Adenosarcoma

Pathways related to Adenosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 ESR1 KIT PGR TP53
2 11.05 KIT MME
3 10.88 ESR1 TP53
4 10.72 ESR1 TP53
5 10.5 ESR1 TP53

GO Terms for Adenosarcoma

Biological processes related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stem cell differentiation GO:0048863 9.26 ESR1 KIT
2 replicative senescence GO:0090399 9.16 MME TP53
3 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 8.96 ESR1 TP53
4 positive regulation of phospholipase C activity GO:0010863 8.62 ESR1 KIT

Molecular functions related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 9.26 ESR1 PGR
2 zinc ion binding GO:0008270 9.26 ESR1 MME PGR TP53
3 core promoter sequence-specific DNA binding GO:0001046 9.16 ESR1 TP53
4 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Adenosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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