MCID: ADN020
MIFTS: 44

Adenosarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Adenosarcoma

MalaCards integrated aliases for Adenosarcoma:

Name: Adenosarcoma 12 56 45 15 17 74
Mullerian Adenosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1974
MeSH 45 D018195
NCIt 51 C9474
SNOMED-CT 69 31470003
UMLS 74 C0001442

Summaries for Adenosarcoma

Disease Ontology : 12 A carcinosarcoma that derives from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

MalaCards based summary : Adenosarcoma, also known as mullerian adenosarcoma, is related to adenofibroma and cystadenoma. An important gene associated with Adenosarcoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Gastric cancer and LKB1 signaling events. The drugs nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and ovary, and related phenotypes are cardiovascular system and cellular

Wikipedia : 77 Adenosarcoma (also Mullerian Adenosarcoma) is a rare malignant tumor that occurs in women of all age... more...

Related Diseases for Adenosarcoma

Diseases related to Adenosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 adenofibroma 30.6 ACTC1 MME
2 cystadenoma 30.4 MME PGR
3 adenomyosis 30.2 ESR1 MME PGR
4 uterine carcinosarcoma 29.6 KIT MME PGR TP53
5 rhabdomyosarcoma 29.5 ACTC1 DES MB TP53
6 endometrial adenocarcinoma 29.2 ESR1 MKI67 PGR TP53
7 carcinosarcoma 29.1 ACTC1 DES KIT MME PGR TP53
8 gastrointestinal stromal tumor 29.1 ACTC1 DES KIT MKI67 TP53
9 smooth muscle tumor 28.6 ACTC1 DES ESR1 KIT MME PGR
10 adenosarcoma of the uterus 12.5
11 ovarian mesodermal adenosarcoma 12.4
12 uterine corpus adenosarcoma 12.4
13 cervical adenosarcoma 12.3
14 vaginal adenosarcoma 12.2
15 fallopian tube adenosarcoma 12.1
16 adenosarcoma of the cervix uteri 12.1
17 adenosarcoma of the corpus uteri 12.0
18 wilms tumor 5 11.2
19 blastema predominant kidney wilms' tumor 11.0
20 epithelial predominant wilms' tumor 11.0
21 endometriosis 10.6
22 spermatocele 10.4 MME PGR
23 endometrial stromal tumor 10.4 MME PGR
24 pancreatic mucinous cystadenoma 10.4 MME PGR
25 renal oncocytoma 10.4 KIT MME
26 congenital epulis 10.4 DES PGR
27 ovarian brenner tumor 10.4 KIT MME
28 rete testis neoplasm 10.4 KIT MME
29 dermoid cyst 10.3 KIT PGR
30 dysgerminoma of ovary 10.3 KIT PGR
31 lymphangiomatosis 10.3 DES PGR
32 meningioma, radiation-induced 10.3 MKI67 PGR
33 benign meningioma 10.3 MKI67 PGR
34 eccrine sweat gland neoplasm 10.3 MME TP53
35 epulis 10.3 DES PGR
36 central nervous system hematologic cancer 10.3 MME TP53
37 mature b-cell neoplasm 10.3 MME TP53
38 gallbladder sarcoma 10.3 DES KIT
39 hemangiopericytoma, malignant 10.3 ACTC1 DES
40 congenital mesoblastic nephroma 10.3 KIT MKI67
41 spindle cell sarcoma 10.3 ACTC1 DES
42 pseudosarcomatous fibromatosis 10.3 ACTC1 DES
43 breast cancer 10.3
44 familial isolated dilated cardiomyopathy 10.3 ACTC1 DES
45 chondromyxoid fibroma 10.3 ACTC1 DES
46 papillary adenocarcinoma 10.3 PGR TP53
47 malignant leydig cell tumor 10.3 KIT MME
48 chickenpox 10.3 ACTC1 PGR
49 primary peritoneal carcinoma 10.3 PGR TP53
50 oropharynx cancer 10.2 KIT TP53

Graphical network of the top 20 diseases related to Adenosarcoma:



Diseases related to Adenosarcoma

Symptoms & Phenotypes for Adenosarcoma

MGI Mouse Phenotypes related to Adenosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ACTC1 DES ESR1 KIT MB PGR
2 cellular MP:0005384 9.87 ACTC1 DES ESR1 KIT MB PGR
3 homeostasis/metabolism MP:0005376 9.86 ACTC1 DES ESR1 KIT MB MME
4 muscle MP:0005369 9.7 ACTC1 DES ESR1 KIT MB PGR
5 no phenotypic analysis MP:0003012 9.35 ESR1 KIT MKI67 PGR TP53
6 normal MP:0002873 9.1 ACTC1 ESR1 KIT MKI67 PGR TP53

Drugs & Therapeutics for Adenosarcoma

Drugs for Adenosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
4
Acetaminophen Approved Phase 2 103-90-2 1983
5
Entinostat Investigational Phase 2 209783-80-2
6 Histone Deacetylase Inhibitors Phase 2,Phase 1
7 Immunoglobulins Phase 2,Phase 1
8 Antibodies, Monoclonal Phase 2,Phase 1
9 Antineoplastic Agents, Immunological Phase 2,Phase 1
10 Antibodies Phase 2,Phase 1
11
Medroxyprogesterone Phase 2 520-85-4 10631
12 Antineoplastic Agents, Hormonal Phase 2
13 Contraceptive Agents Phase 2
14 Contraceptive Agents, Male Phase 2
15 Contraceptives, Oral Phase 2
16
Fluorouracil Approved Phase 1 51-21-8 3385
17
Belinostat Approved, Investigational Phase 1 866323-14-0
18
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
19
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
20
Bevacizumab Approved, Investigational Phase 1 216974-75-3
21 Immunosuppressive Agents Phase 1
22 Antimetabolites Phase 1
23 Androgens Phase 1
24 Immunologic Factors Phase 1
25 Antimetabolites, Antineoplastic Phase 1
26 Immunoglobulin G Phase 1
27 Angiogenesis Modulating Agents Phase 1
28 Angiogenesis Inhibitors Phase 1
29 Albumin-Bound Paclitaxel Phase 1
30 Antimitotic Agents Phase 1
31 Endothelial Growth Factors Phase 1
32 Antineoplastic Agents, Phytogenic Phase 1
33 Mitogens Phase 1
34
tannic acid Approved Not Applicable 1401-55-4
35
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
2 Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer Active, not recruiting NCT03018249 Phase 2 Entinostat;Medroxyprogesterone Acetate
3 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)
4 Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00413075 Phase 1 oral belinostat
5 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Recruiting NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation
6 The Effects of Moderate Exercise on Distress, Quality of Life, and Biomarkers of Angiogenesis and Chronic Stress in Ovarian Cancer Survivors Recruiting NCT03641287 Not Applicable

Search NIH Clinical Center for Adenosarcoma

Cochrane evidence based reviews: adenosarcoma

Genetic Tests for Adenosarcoma

Anatomical Context for Adenosarcoma

MalaCards organs/tissues related to Adenosarcoma:

42
Uterus, Cervix, Ovary, Liver, Kidney, Breast, Endothelial

Publications for Adenosarcoma

Articles related to Adenosarcoma:

(show top 50) (show all 259)
# Title Authors Year
1
Mullerian adenosarcoma (heterologous) of uterine cervix with sarcomatous overgrowth: A case report with review of the literature. ( 30706880 )
2019
2
Dedifferentiated Carcinoma of the Endometrium Associated With Low-Grade Müllerian Adenosarcoma: A Clinicopathologic Case Report Including the Immunohistochemical and Molecular Profile. ( 30908285 )
2019
3
A Single-Centre Experience on the Management of Adenosarcoma: A Successful Report of an Integrated Medical and Surgical Approach. ( 29977120 )
2018
4
Uterine preservation in a young patient with adenosarcoma of the uterus - Case report and review of literature. ( 29977987 )
2018
5
Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review. ( 29402239 )
2018
6
Uterine adenosarcoma with sarcomatous overgrowth: A case report of aggressive disease in a 16-year-old girl and a literature review. ( 29317258 )
2018
7
Uterine adenosarcoma in Japan: Clinicopathologic features, diagnosis and management. ( 29441675 )
2018
8
Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma. ( 30004077 )
2018
9
Low grade Mullerian adenosarcoma of pouch of Douglas recurring as bilateral ovarian high grade Mullerian adenosarcoma with rhabdomyosarcomatous overgrowth after 11 years. ( 30108400 )
2018
10
Clinical management of uterine cervical mullerian adenosarcoma: A clinicopathological study of six cases and review of the literature. ( 30122564 )
2018
11
Prognostic factors for uterine adenosarcoma: a review. ( 30169984 )
2018
12
Uterine Adenosarcoma. ( 30326467 )
2018
13
Imaging Description of Extragenital Müllerian Adenosarcoma: A Case Report. ( 30541177 )
2018
14
Polypoid adenosarcoma of uterus with chondroid differentiation: A rare diagnosis. ( 29323096 )
2017
15
Ovarian metastasis of MA1llerian adenosarcoma of the cervix with sarcomatous overgrowth. ( 29085712 )
2017
16
A case of a primary hepatic so-called adenosarcoma with heterotopic ossification: possibly of biliary adenofibroma origin. ( 29079182 )
2017
17
MA1llerian Adenosarcoma of the Urinary Bladder: Clinicopathologic and Immunohistochemical Features With Novel Genetic Aberrations. ( 28690098 )
2017
18
Endometrial adenosarcoma in the setting of a germline DICER1 mutation: A case report. ( 28459098 )
2017
19
A Rare Case of Intramural MA1llerian Adenosarcoma Arising from Adenomyosis of the Uterus. ( 28741605 )
2017
20
Management of Low-Grade Cervical MA1llerian Adenosarcoma in a 14-Year-Old Girl. ( 28578185 )
2017
21
Treatment of Recurrent or Metastatic Uterine Adenosarcoma. ( 29445312 )
2017
22
Case Report of Successful Childbearing after Conservative Surgery for Cervical Mullerian Adenosarcoma. ( 28154764 )
2017
23
Significance of lymph node metastasis on survival of women with uterine adenosarcoma. ( 28109626 )
2017
24
MR Imaging of an Intramural Adenosarcoma with Pathologic Correlation. ( 28529247 )
2017
25
Embryo Cryopreservation Following In-Vitro Maturation for Fertility Preservation in a Woman with Mullerian Adenosarcoma: A Case Report. ( 28904505 )
2017
26
High-grade MA1llerian Adenosarcoma: Genomic and Clinicopathologic Characterization of a Distinct Neoplasm With Prevalent TP53 Pathway Alterations and Aggressive Behavior. ( 28834809 )
2017
27
A Case of Solitary Brain Metastasis from Uterine Mullerian Adenosarcoma with Sarcomatous Overgrowth. ( 27867926 )
2016
28
Submucous uterine adenosarcoma-minimally invasive treatment. ( 27769260 )
2016
29
Role of dacarbazine in the treatment of recurrent mullerian adenosarcoma with sarcomatous overgrowth: Our experience. ( 27139896 )
2016
30
Mullerian adenosarcoma of the cervix with heterologous elements and sarcomatous overgrowth. ( 26722175 )
2016
31
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034793 )
2016
32
Survival of women with Mullerian adenosarcoma: A National Cancer Data Base study. ( 27771166 )
2016
33
Uterine Adenosarcoma. ( 26927725 )
2016
34
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 27041653 )
2016
35
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034795 )
2016
36
Uterine Adenosarcoma: a Review. ( 27718181 )
2016
37
MA1llerian adenosarcoma of the uterine cervix with sarcomatous overgrowth: A case report of aggressive disease in a young patient. ( 27621097 )
2016
38
Involvement of Chromosome 8 in MA1llerian Adenosarcoma. ( 26974998 )
2016
39
Hemoperitoneum due to breaking uterine adenosarcoma located in the omentum. Report of a case. ( 28003568 )
2016
40
Extensive Overgrowth of Sex Cord-Like Differentiation in Uterine Mullerian Adenosarcoma: A Rare and Challenging Entity. ( 26840033 )
2016
41
Genomewide copy number analysis of MA1llerian adenosarcoma identified chromosomal instability in the aggressive subgroup. ( 27255164 )
2016
42
Juvenile granulosa cell tumor arising in ovarian adenosarcoma: an unusual form of sarcomatous overgrowth. ( 25656930 )
2015
43
Advanced Mesodermal (MA1llerian) Adenosarcoma of the Ovary: Metastases to the Lungs, Mouth, and Brain. ( 26844003 )
2015
44
Uterine adenosarcoma with omentum metastasis complicated by a rapidly progressing liver abscess. ( 26166355 )
2015
45
Mullerian adenosarcoma of the uterus associated with tamoxifen treatment for breast cancer. ( 28913077 )
2015
46
MA1llerian Adenosarcoma: A Malignant Progression of Adenomyosis? Pictorial Review With Multimodality Imaging. ( 26446823 )
2015
47
Extrauterine adenosarcoma arising in omental endometriosis: Rare site of occurrence of a rare tumor. ( 25308029 )
2014
48
Extragenital mA1llerian adenosarcoma in the pouch of douglas. ( 25207177 )
2014
49
MA1llerian adenosarcoma: a review of cases and literature. ( 25556263 )
2014
50
Targeted genomic analysis of MA1llerian adenosarcoma. ( 25231023 )
2014

Variations for Adenosarcoma

Expression for Adenosarcoma

Search GEO for disease gene expression data for Adenosarcoma.

Pathways for Adenosarcoma

Pathways related to Adenosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 ESR1 KIT PGR TP53
2 10.88 ESR1 TP53
3 10.72 ESR1 TP53
4 10.5 ESR1 TP53

GO Terms for Adenosarcoma

Biological processes related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.32 ACTC1 DES
2 stem cell differentiation GO:0048863 9.26 ESR1 KIT
3 positive regulation of phospholipase C activity GO:0010863 9.16 ESR1 KIT
4 replicative senescence GO:0090399 8.96 MME TP53
5 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 8.62 ESR1 TP53

Molecular functions related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
2 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Adenosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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