Adenosquamous Bile Duct Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Adenosquamous Bile Duct Carcinoma

MalaCards integrated aliases for Adenosquamous Bile Duct Carcinoma:

Name: Adenosquamous Bile Duct Carcinoma ¹² ¹⁵ ⁷¹

Bile Duct Adenosquamous Carcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5624

NCIt ⁵⁰ C5778

UMLS ⁷¹ C0861854

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Summaries for Adenosquamous Bile Duct Carcinoma

Disease Ontology : ¹² A bile duct carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Adenosquamous Bile Duct Carcinoma, also known as bile duct adenosquamous carcinoma, is related to postgastrectomy syndrome and functional gastric disease, and has symptoms including vomiting, abdominal pain and pruritus. An important gene associated with Adenosquamous Bile Duct Carcinoma is GIP (Gastric Inhibitory Polypeptide), and among its related pathways/superpathways are Presynaptic function of Kainate receptors and cAMP signaling pathway.

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Related Diseases for Adenosquamous Bile Duct Carcinoma

Diseases related to Adenosquamous Bile Duct Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)

#	Related Disease	Score	Top Affiliating Genes
1	postgastrectomy syndrome	10.0	GIP GCG
2	functional gastric disease	9.9	GIP GCG
3	dumping syndrome	9.9	GIP GCG
4	nuclear senile cataract	9.9	MT-CO1 GIP
5	splenic flexure cancer	9.8	GCG DPP4
6	pancreatic colloid cystadenoma	9.8	GCG DPP4
7	hypoglycemic coma	9.8	GCG DPP4
8	diabetes mellitus, ketosis-prone	9.8	GCG DPP4
9	maturity-onset diabetes of the young, type 1	9.8	GCG DPP4
10	maturity-onset diabetes of the young	9.8	GCG DPP4
11	prediabetes syndrome	9.7	GCG DPP4
12	glucose intolerance	9.7	GCG DPP4
13	hyperinsulinism	9.7	GCG DPP4
14	leptin deficiency or dysfunction	9.6	GCG DPP4
15	celiac disease 1	9.6	GCG DPP4
16	barre-lieou syndrome	9.5	GIP GCG DPP4
17	nasopharyngitis	9.5	GIP GCG DPP4
18	glucose metabolism disease	9.5	GIP GCG DPP4
19	acquired metabolic disease	9.5	GIP GCG DPP4
20	hyperglycemia	9.5	GIP GCG DPP4
21	squamous cell bile duct carcinoma	9.5	MT-CO1 GIP DPP4
22	hypoglycemia	9.5	GCG DPP4
23	body mass index quantitative trait locus 11	9.4	GIP GCG DPP4
24	type 2 diabetes mellitus	9.1	MT-CO1 GIP GCG DPP4

Graphical network of the top 20 diseases related to Adenosquamous Bile Duct Carcinoma:

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Symptoms & Phenotypes for Adenosquamous Bile Duct Carcinoma

UMLS symptoms related to Adenosquamous Bile Duct Carcinoma:

vomiting, abdominal pain, pruritus, nausea, icterus, malaise

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Drugs & Therapeutics for Adenosquamous Bile Duct Carcinoma

Search Clinical Trials , NIH Clinical Center for Adenosquamous Bile Duct Carcinoma

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Genetic Tests for Adenosquamous Bile Duct Carcinoma

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Anatomical Context for Adenosquamous Bile Duct Carcinoma

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Publications for Adenosquamous Bile Duct Carcinoma

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Genes for Adenosquamous Bile Duct Carcinoma

Genes related to Adenosquamous Bile Duct Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GIP	Gastric Inhibitory Polypeptide	Protein Coding	4.74	DISEASES inferred ¹⁵
2	MT-CO1	Mitochondrially Encoded Cytochrome C Oxidase I	Protein Coding	4.66	DISEASES inferred ¹⁵
3	DPP4	Dipeptidyl Peptidase 4	Protein Coding	4.09	DISEASES inferred ¹⁵
4	GCG	Glucagon	Protein Coding	3.72	DISEASES inferred ¹⁵

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Variations for Adenosquamous Bile Duct Carcinoma

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Expression for Adenosquamous Bile Duct Carcinoma

Search GEO for disease gene expression data for Adenosquamous Bile Duct Carcinoma.

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Pathways for Adenosquamous Bile Duct Carcinoma

Pathways related to Adenosquamous Bile Duct Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Presynaptic function of Kainate receptors ⁶⁵ Show member pathways Activation of Ca-permeable Kainate Receptor ⁶⁵ Activation of Kainate Receptors upon glutamate binding ⁶⁵ Activation of Na-permeable Kainate Receptors ⁶⁵ Calcitonin-like ligand receptors ⁶⁵ Class B/2 (Secretin family receptors) ⁶⁵ G beta-gamma signalling through PLC beta ⁶⁵ Glucagon-type ligand receptors ⁶⁵ G-Protein Signaling through Tubby Protein ⁶³ Ionotropic activity of Kainate Receptors ⁶⁵	11.72	GIP GCG
2	cAMP signaling pathway ³⁶	11.59	GIP GCG
3	Peptide hormone metabolism ⁶⁵ Show member pathways Glycoprotein hormones ⁶⁵ Insulin processing ⁶⁵ Metabolism of Angiotensinogen to Angiotensins ⁶⁵ Peptide hormone biosynthesis ⁶⁵ Synthesis, secretion, and deacylation of Ghrelin ⁶⁵	11.39	GIP GCG DPP4
4	G alpha (s) signalling events ⁶⁵	11.32	GIP GCG
5	Incretin synthesis, secretion, and inactivation ⁶⁵ Show member pathways Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ⁶⁵ Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) ⁶⁵	10.55	GIP GCG DPP4

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GO Terms for Adenosquamous Bile Duct Carcinoma

Cellular components related to Adenosquamous Bile Duct Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule lumen	GO:0034774	8.62	GIP GCG

Biological processes related to Adenosquamous Bile Duct Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of insulin secretion	GO:0050796	8.8	GIP GCG DPP4

Molecular functions related to Adenosquamous Bile Duct Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.16	GIP GCG
2	signaling receptor binding	GO:0005102	9.13	GIP GCG DPP4
3	glucagon receptor binding	GO:0031769	8.62	GIP GCG

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Sources for Adenosquamous Bile Duct Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia