MCID: ADN006
MIFTS: 36

Adenosquamous Colon Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Adenosquamous Colon Carcinoma

MalaCards integrated aliases for Adenosquamous Colon Carcinoma:

Name: Adenosquamous Colon Carcinoma 12 15
Adenosquamous Carcinoma of Colon 12
Colonic Adenosquamous Carcinoma 12
Colon Adenosquamous Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5629
NCIt 50 C5491
UMLS 73 C1333082

Summaries for Adenosquamous Colon Carcinoma

Disease Ontology : 12 A colon carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Adenosquamous Colon Carcinoma, also known as adenosquamous carcinoma of colon, is related to mucinous adenocarcinoma and lynch syndrome, and has symptoms including constipation, fever and abdominal pain. An important gene associated with Adenosquamous Colon Carcinoma is PMS2 (PMS1 Homolog 2, Mismatch Repair System Component), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Regulation of TP53 Activity. Affiliated tissues include colon, skin and brain, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Synthetic lethal with vaccinia virus (VACV) infection

Related Diseases for Adenosquamous Colon Carcinoma

Diseases related to Adenosquamous Colon Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 mucinous adenocarcinoma 29.8 CDX2 MLH1
2 lynch syndrome 29.3 MLH1 MSH2 MSH6 PMS2
3 jejunal adenocarcinoma 10.0 CDX2 MSH6
4 neurofibromatosis, type iv, of riccardi 10.0 MSH6 PMS2
5 attenuated familial adenomatous polyposis 10.0 MSH2 MSH6
6 adenosquamous carcinoma 10.0
7 adenocarcinoma 10.0
8 legius syndrome 10.0 MSH2 MSH6
9 spindle cell intraocular melanoma 10.0 MLH1 PMS2
10 colorectal cancer 5 9.9 MLH1 MSH6
11 gastric leiomyoma 9.9 MLH1 MSH6
12 microinvasive gastric cancer 9.9 CDX2 MLH1
13 colorectal cancer, hereditary nonpolyposis, type 7 9.9 MLH1 MSH2
14 lower lip cancer 9.9 MLH1 MSH2
15 anal fistula 9.9 MLH1 MSH2
16 melanocytic nevus syndrome, congenital 9.9 MLH1 MSH2
17 childhood kidney cell carcinoma 9.9 MLH1 MSH2
18 hereditary breast ovarian cancer syndrome 9.8 MLH1 MSH6
19 keratoacanthoma 9.8 MLH1 MSH2
20 familial colorectal cancer 9.8 MLH1 MSH2
21 stomach disease 9.8 CDX2 MLH1
22 colorectal adenoma 9.8 MLH1 MSH2
23 rhabdomyosarcoma 9.8 MSH2 MSH6 PMS2
24 brain cancer 9.8 MSH2 MSH6 PMS2
25 rectal neoplasm 9.8 MLH1 MSH2
26 gastrointestinal system disease 9.8 MLH1 MSH2
27 colorectal cancer, hereditary nonpolyposis, type 4 9.7 MLH1 MSH2 PMS2
28 ulcerative colitis 9.7 MLH1 MSH2
29 intestinal benign neoplasm 9.7 CDX2 MLH1 MSH2
30 skin benign neoplasm 9.7 MLH1 MSH2 MSH6
31 colorectal cancer, hereditary nonpolyposis, type 5 9.7 MLH1 MSH2 MSH6
32 female reproductive system disease 9.7 MLH1 MSH2 MSH6
33 familial adenomatous polyposis 9.7 MLH1 MSH2 MSH6
34 colon adenocarcinoma 9.7 MLH1 MSH6
35 appendix carcinoid tumor 9.6 MLH1 MSH2 MSH6 PMS2
36 sebaceous adenoma 9.6 MLH1 MSH2 MSH6 PMS2
37 lynch syndrome i 9.6 MLH1 MSH2 MSH6 PMS2
38 sebaceous adenocarcinoma 9.5 MLH1 MSH2 MSH6 PMS2
39 muir-torre syndrome 9.5 MLH1 MSH2 MSH6 PMS2
40 mismatch repair cancer syndrome 9.5 MLH1 MSH2 MSH6 PMS2
41 uterine anomalies 9.5 MLH1 MSH2 MSH6 PMS2
42 autosomal genetic disease 9.5 MLH1 MSH2 MSH6 PMS2
43 autosomal dominant disease 9.5 MLH1 MSH2 MSH6 PMS2
44 cecum adenocarcinoma 9.5 CDX2 MLH1 MSH2 MSH6
45 endometrial cancer 9.5 MLH1 MSH2 MSH6 PMS2
46 colorectal adenocarcinoma 9.5 CDX2 MLH1 MSH2 MSH6
47 small intestine cancer 9.4 CDX2 MLH1 MSH2 MSH6 PMS2
48 colonic disease 9.4 CDX2 MLH1 MSH2 MSH6 PMS2
49 intestinal disease 9.4 CDX2 MLH1 MSH2 MSH6 PMS2
50 gastrointestinal system cancer 9.4 CDX2 MLH1 MSH2 MSH6 PMS2

Graphical network of the top 20 diseases related to Adenosquamous Colon Carcinoma:



Diseases related to Adenosquamous Colon Carcinoma

Symptoms & Phenotypes for Adenosquamous Colon Carcinoma

UMLS symptoms related to Adenosquamous Colon Carcinoma:


constipation, fever, abdominal pain

GenomeRNAi Phenotypes related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.26 MLH1 MSH2 MSH6 PMS2
2 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 CDX2 MLH1 MSH6 PMS2

MGI Mouse Phenotypes related to Adenosquamous Colon Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.72 CDX2 MLH1 MSH2 MSH6 PMS2
2 digestive/alimentary MP:0005381 9.56 CDX2 MLH1 MSH2 PMS2
3 homeostasis/metabolism MP:0005376 9.55 CDX2 MLH1 MSH2 MSH6 PMS2
4 mortality/aging MP:0010768 9.35 CDX2 MLH1 MSH2 MSH6 PMS2
5 neoplasm MP:0002006 9.02 CDX2 MLH1 MSH2 MSH6 PMS2

Drugs & Therapeutics for Adenosquamous Colon Carcinoma

Search Clinical Trials , NIH Clinical Center for Adenosquamous Colon Carcinoma

Genetic Tests for Adenosquamous Colon Carcinoma

Anatomical Context for Adenosquamous Colon Carcinoma

MalaCards organs/tissues related to Adenosquamous Colon Carcinoma:

41
Colon, Skin, Brain, Kidney, Breast, Small Intestine, Appendix

Publications for Adenosquamous Colon Carcinoma

Articles related to Adenosquamous Colon Carcinoma:

# Title Authors Year
1
Adenosquamous carcinoma of colon. ( 11817779 )
2001

Variations for Adenosquamous Colon Carcinoma

Expression for Adenosquamous Colon Carcinoma

Search GEO for disease gene expression data for Adenosquamous Colon Carcinoma.

Pathways for Adenosquamous Colon Carcinoma

Pathways related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 MLH1 MSH2 MSH6 PMS2
2
Show member pathways
12.56 MLH1 MSH2 PMS2
3
Show member pathways
12.51 MLH1 MSH2 MSH6
4
Show member pathways
12.45 MLH1 MSH2 MSH6
5 12.41 MLH1 MSH2 MSH6
6 12.08 MLH1 MSH2 MSH6
7 11.72 MLH1 MSH2 MSH6
8 11.55 MLH1 MSH2 PMS2
9 11.52 MLH1 PMS2
10
Show member pathways
11.46 MSH2 MSH6
11
Show member pathways
11.25 MLH1 MSH2 MSH6 PMS2
12 11.2 MLH1 MSH2 MSH6
13 11.16 MSH2 MSH6
14 11.15 MLH1 MSH2 MSH6
15
Show member pathways
11.12 MLH1 MSH2
16
Show member pathways
11.06 MLH1 MSH2
17 10.39 MLH1 MSH2 MSH6 PMS2

GO Terms for Adenosquamous Colon Carcinoma

Cellular components related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.72 CDX2 MLH1 MSH2 MSH6 PMS2
2 condensed nuclear chromosome GO:0000794 9.26 CDX2 MLH1
3 MutLalpha complex GO:0032389 9.16 MLH1 PMS2
4 MutSalpha complex GO:0032301 8.96 MSH2 MSH6
5 mismatch repair complex GO:0032300 8.92 MLH1 MSH2 MSH6 PMS2

Biological processes related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.81 MLH1 MSH2 MSH6 PMS2
2 DNA repair GO:0006281 9.71 MLH1 MSH2 MSH6 PMS2
3 interstrand cross-link repair GO:0036297 9.58 MSH2 MSH6
4 negative regulation of DNA recombination GO:0045910 9.57 MSH2 MSH6
5 determination of adult lifespan GO:0008340 9.56 MSH2 MSH6
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.55 MLH1 MSH2
7 positive regulation of helicase activity GO:0051096 9.54 MSH2 MSH6
8 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.54 MLH1 MSH2 MSH6
9 pyrimidine dimer repair GO:0006290 9.52 MSH2 MSH6
10 replication fork arrest GO:0043111 9.49 MSH2 MSH6
11 maintenance of DNA repeat elements GO:0043570 9.48 MSH2 MSH6
12 positive regulation of isotype switching to IgA isotypes GO:0048298 9.46 MLH1 MSH2
13 meiotic mismatch repair GO:0000710 9.43 MSH2 MSH6
14 isotype switching GO:0045190 9.43 MLH1 MSH2 MSH6
15 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MLH1 MSH2 MSH6
16 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MLH1 MSH2
17 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 PMS2
18 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 MLH1 MSH2 MSH6 PMS2

Molecular functions related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.88 CDX2 MSH2 MSH6 PMS2
2 ATP binding GO:0005524 9.86 MLH1 MSH2 MSH6 PMS2
3 chromatin binding GO:0003682 9.72 MLH1 MSH2 MSH6
4 enzyme binding GO:0019899 9.71 MLH1 MSH2 MSH6
5 double-stranded DNA binding GO:0003690 9.65 CDX2 MSH2 MSH6
6 damaged DNA binding GO:0003684 9.57 MSH2 MSH6
7 single-stranded DNA binding GO:0003697 9.54 MLH1 MSH2 PMS2
8 DNA-dependent ATPase activity GO:0008094 9.52 MSH2 MSH6
9 ADP binding GO:0043531 9.51 MSH2 MSH6
10 four-way junction DNA binding GO:0000400 9.49 MSH2 MSH6
11 MutLalpha complex binding GO:0032405 9.46 MSH2 MSH6
12 ATPase activity GO:0016887 9.46 MLH1 MSH2 MSH6 PMS2
13 MutSalpha complex binding GO:0032407 9.43 MLH1 PMS2
14 oxidized purine DNA binding GO:0032357 9.4 MSH2 MSH6
15 single thymine insertion binding GO:0032143 9.32 MSH2 MSH6
16 single guanine insertion binding GO:0032142 9.26 MSH2 MSH6
17 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
18 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS2

Sources for Adenosquamous Colon Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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