MCID: ADN006
MIFTS: 29

Adenosquamous Colon Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Adenosquamous Colon Carcinoma

MalaCards integrated aliases for Adenosquamous Colon Carcinoma:

Name: Adenosquamous Colon Carcinoma 12 15
Adenosquamous Carcinoma of Colon 12
Colonic Adenosquamous Carcinoma 12
Colon Adenosquamous Carcinoma 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5629
NCIt 50 C5491
UMLS 72 C1333082

Summaries for Adenosquamous Colon Carcinoma

Disease Ontology : 12 A colon carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Adenosquamous Colon Carcinoma, also known as adenosquamous carcinoma of colon, is related to mucinous adenocarcinoma and lynch syndrome, and has symptoms including constipation, fever and abdominal pain. An important gene associated with Adenosquamous Colon Carcinoma is PMS2 (PMS1 Homolog 2, Mismatch Repair System Component), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Regulation of TP53 Activity. Affiliated tissues include colon, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Synthetic lethal with vaccinia virus (VACV) infection

Related Diseases for Adenosquamous Colon Carcinoma

Diseases related to Adenosquamous Colon Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 mucinous adenocarcinoma 29.6 MLH1 CDX2
2 lynch syndrome 28.3 PMS2 MSH6 MSH2 MLH1
3 adenosquamous carcinoma 10.2
4 jejunal adenocarcinoma 10.0 MSH6 CDX2
5 adenocarcinoma 10.0
6 appendix adenocarcinoma 10.0
7 tubular adenocarcinoma 10.0
8 attenuated familial adenomatous polyposis 10.0 MSH6 MSH2
9 neurofibromatosis, type iv, of riccardi 10.0 PMS2 MSH6
10 legius syndrome 9.9 MSH6 MSH2
11 spindle cell intraocular melanoma 9.9 PMS2 MLH1
12 colorectal cancer 5 9.8 MSH6 MLH1
13 gastric leiomyoma 9.8 MSH6 MLH1
14 microinvasive gastric cancer 9.7 MLH1 CDX2
15 colorectal cancer, hereditary nonpolyposis, type 7 9.7 MSH2 MLH1
16 lower lip cancer 9.7 MSH2 MLH1
17 anal fistula 9.7 MSH2 MLH1
18 melanocytic nevus syndrome, congenital 9.7 MSH2 MLH1
19 childhood kidney cell carcinoma 9.7 MSH2 MLH1
20 keratoacanthoma 9.6 MSH2 MLH1
21 hereditary breast ovarian cancer syndrome 9.6 MSH6 MLH1
22 familial colorectal cancer 9.6 MSH2 MLH1
23 colorectal adenoma 9.5 MSH2 MLH1
24 rhabdomyosarcoma 9.5 PMS2 MSH6 MSH2
25 stomach disease 9.5 MLH1 CDX2
26 brain cancer 9.5 PMS2 MSH6 MSH2
27 gastrointestinal system disease 9.4 MSH2 MLH1
28 colorectal cancer, hereditary nonpolyposis, type 4 9.3 PMS2 MSH2 MLH1
29 ulcerative colitis 9.3 MSH2 MLH1
30 intestinal benign neoplasm 9.3 MSH2 MLH1 CDX2
31 skin benign neoplasm 9.3 MSH6 MSH2 MLH1
32 colorectal cancer, hereditary nonpolyposis, type 5 9.3 MSH6 MSH2 MLH1
33 female reproductive system disease 9.2 MSH6 MSH2 MLH1
34 familial adenomatous polyposis 9.2 MSH6 MSH2 MLH1
35 colon adenocarcinoma 9.2 MSH6 MLH1
36 appendix carcinoid tumor 8.9 PMS2 MSH6 MSH2 MLH1
37 sebaceous adenoma 8.9 PMS2 MSH6 MSH2 MLH1
38 lynch syndrome i 8.9 PMS2 MSH6 MSH2 MLH1
39 sebaceous adenocarcinoma 8.9 PMS2 MSH6 MSH2 MLH1
40 muir-torre syndrome 8.9 PMS2 MSH6 MSH2 MLH1
41 mismatch repair cancer syndrome 8.9 PMS2 MSH6 MSH2 MLH1
42 uterine anomalies 8.8 PMS2 MSH6 MSH2 MLH1
43 autosomal genetic disease 8.8 PMS2 MSH6 MSH2 MLH1
44 cecum adenocarcinoma 8.8 MSH6 MSH2 MLH1 CDX2
45 endometrial cancer 8.8 PMS2 MSH6 MSH2 MLH1
46 colorectal adenocarcinoma 8.8 MSH6 MSH2 MLH1 CDX2
47 small intestine cancer 8.4 PMS2 MSH6 MSH2 MLH1 CDX2
48 colonic disease 8.4 PMS2 MSH6 MSH2 MLH1 CDX2
49 intestinal disease 8.4 PMS2 MSH6 MSH2 MLH1 CDX2
50 gastrointestinal system cancer 8.4 PMS2 MSH6 MSH2 MLH1 CDX2

Graphical network of the top 20 diseases related to Adenosquamous Colon Carcinoma:



Diseases related to Adenosquamous Colon Carcinoma

Symptoms & Phenotypes for Adenosquamous Colon Carcinoma

UMLS symptoms related to Adenosquamous Colon Carcinoma:


constipation, fever, abdominal pain

GenomeRNAi Phenotypes related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.26 MLH1 MSH2 MSH6 PMS2
2 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 CDX2 MLH1 MSH6 PMS2

MGI Mouse Phenotypes related to Adenosquamous Colon Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.72 CDX2 MLH1 MSH2 MSH6 PMS2
2 digestive/alimentary MP:0005381 9.56 CDX2 MLH1 MSH2 PMS2
3 homeostasis/metabolism MP:0005376 9.55 CDX2 MLH1 MSH2 MSH6 PMS2
4 mortality/aging MP:0010768 9.35 CDX2 MLH1 MSH2 MSH6 PMS2
5 neoplasm MP:0002006 9.02 CDX2 MLH1 MSH2 MSH6 PMS2

Drugs & Therapeutics for Adenosquamous Colon Carcinoma

Search Clinical Trials , NIH Clinical Center for Adenosquamous Colon Carcinoma

Genetic Tests for Adenosquamous Colon Carcinoma

Anatomical Context for Adenosquamous Colon Carcinoma

MalaCards organs/tissues related to Adenosquamous Colon Carcinoma:

41
Colon

Publications for Adenosquamous Colon Carcinoma

Articles related to Adenosquamous Colon Carcinoma:

# Title Authors PMID Year
1
Colonic adenosquamous carcinoma and mucinous adenocarcinoma with microsatellite instability. 38
30173239 2018
2
An Unusual Variant of Adenocarcinoma of the Left Colon Associated With Microsatellite Instability: A Case Report. 38
28537083 2017

Variations for Adenosquamous Colon Carcinoma

Expression for Adenosquamous Colon Carcinoma

Search GEO for disease gene expression data for Adenosquamous Colon Carcinoma.

Pathways for Adenosquamous Colon Carcinoma

Pathways related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 PMS2 MSH6 MSH2 MLH1
2
Show member pathways
12.56 PMS2 MSH2 MLH1
3
Show member pathways
12.51 MSH6 MSH2 MLH1
4
Show member pathways
12.45 MSH6 MSH2 MLH1
5 12.41 MSH6 MSH2 MLH1
6 12.08 MSH6 MSH2 MLH1
7 11.72 MSH6 MSH2 MLH1
8 11.55 PMS2 MSH2 MLH1
9 11.52 PMS2 MLH1
10
Show member pathways
11.46 MSH6 MSH2
11
Show member pathways
11.23 PMS2 MSH6 MSH2 MLH1
12 11.2 MSH6 MSH2 MLH1
13 11.16 MSH6 MSH2
14 11.15 MSH6 MSH2 MLH1
15
Show member pathways
11.12 MSH2 MLH1
16
Show member pathways
11.06 MSH2 MLH1
17 10.39 PMS2 MSH6 MSH2 MLH1

GO Terms for Adenosquamous Colon Carcinoma

Cellular components related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.72 PMS2 MSH6 MSH2 MLH1 CDX2
2 condensed nuclear chromosome GO:0000794 9.26 MLH1 CDX2
3 MutLalpha complex GO:0032389 9.16 PMS2 MLH1
4 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
5 mismatch repair complex GO:0032300 8.92 PMS2 MSH6 MSH2 MLH1

Biological processes related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.8 PMS2 MSH6 MSH2 MLH1
2 DNA repair GO:0006281 9.71 PMS2 MSH6 MSH2 MLH1
3 negative regulation of DNA recombination GO:0045910 9.56 MSH6 MSH2
4 determination of adult lifespan GO:0008340 9.55 MSH6 MSH2
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.54 MSH2 MLH1
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.54 MSH6 MSH2 MLH1
7 positive regulation of helicase activity GO:0051096 9.52 MSH6 MSH2
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.48 MSH2 MLH1
9 maintenance of DNA repeat elements GO:0043570 9.46 MSH6 MSH2
10 isotype switching GO:0045190 9.43 MSH6 MSH2 MLH1
11 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MSH6 MSH2 MLH1
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MSH2 MLH1
13 interstrand cross-link repair GO:0036297 9.27 MSH6
14 mismatch repair GO:0006298 9.26 PMS2 MSH6 MSH2 MLH1
15 pyrimidine dimer repair GO:0006290 9.21 MSH6
16 meiotic mismatch repair GO:0000710 9.13 MSH6
17 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 PMS2 MSH6 MSH2 MLH1

Molecular functions related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.88 PMS2 MSH6 MSH2 CDX2
2 ATP binding GO:0005524 9.86 PMS2 MSH6 MSH2 MLH1
3 chromatin binding GO:0003682 9.72 MSH6 MSH2 MLH1
4 enzyme binding GO:0019899 9.71 MSH6 MSH2 MLH1
5 double-stranded DNA binding GO:0003690 9.65 MSH6 MSH2 CDX2
6 damaged DNA binding GO:0003684 9.57 MSH6 MSH2
7 single-stranded DNA binding GO:0003697 9.54 PMS2 MSH2 MLH1
8 DNA-dependent ATPase activity GO:0008094 9.52 MSH6 MSH2
9 ADP binding GO:0043531 9.51 MSH6 MSH2
10 four-way junction DNA binding GO:0000400 9.49 MSH6 MSH2
11 oxidized purine DNA binding GO:0032357 9.46 MSH6 MSH2
12 ATPase activity GO:0016887 9.46 PMS2 MSH6 MSH2 MLH1
13 MutSalpha complex binding GO:0032407 9.43 PMS2 MLH1
14 MutLalpha complex binding GO:0032405 9.4 MSH6 MSH2
15 single thymine insertion binding GO:0032143 9.32 MSH6 MSH2
16 single guanine insertion binding GO:0032142 9.26 MSH6 MSH2
17 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
18 mismatched DNA binding GO:0030983 8.92 PMS2 MSH6 MSH2 MLH1

Sources for Adenosquamous Colon Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....