MCID: ADN006
MIFTS: 32

Adenosquamous Colon Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Adenosquamous Colon Carcinoma

MalaCards integrated aliases for Adenosquamous Colon Carcinoma:

Name: Adenosquamous Colon Carcinoma 12 15
Adenosquamous Carcinoma of Colon 12
Colonic Adenosquamous Carcinoma 12
Colon Adenosquamous Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5629
NCIt 49 C5491
UMLS 71 C1333082

Summaries for Adenosquamous Colon Carcinoma

Disease Ontology : 12 A colon carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Adenosquamous Colon Carcinoma, also known as adenosquamous carcinoma of colon, is related to appendix adenocarcinoma and tubular adenocarcinoma, and has symptoms including constipation, fever and abdominal pain. An important gene associated with Adenosquamous Colon Carcinoma is PMS2 (PMS1 Homolog 2, Mismatch Repair System Component), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Pathways in cancer. Affiliated tissues include colon, appendix and ovary, and related phenotypes are Increased replication of vaccinia virus (VACV) and Increased viability with MLN4924 (a NAE inhibitor)

Related Diseases for Adenosquamous Colon Carcinoma

Diseases related to Adenosquamous Colon Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 appendix adenocarcinoma 29.8 KRT7 CDX2
2 tubular adenocarcinoma 29.5 KRT7 CDX2
3 mucinous adenocarcinoma 29.3 MLH1 KRT7 CDX2
4 lynch syndrome 29.1 PMS2 MSH6 MSH2 MLH1
5 adenocarcinoma 28.0 MSH6 MSH2 MLH1 KRT7 CDX2
6 periampullary adenoma 10.2 PMS2 MSH6
7 fallopian tube endometrioid adenocarcinoma 10.2 PMS2 MSH6
8 adenosquamous carcinoma 10.2
9 attenuated familial adenomatous polyposis 10.1 MSH6 MSH2
10 spindle cell intraocular melanoma 10.1 PMS2 MLH1
11 colorectal cancer, hereditary nonpolyposis, type 4 10.1 PMS2 MLH1
12 legius syndrome 10.0 MSH6 MSH2
13 transverse colon cancer 10.0 MLH1 KRT7
14 lower lip cancer 10.0 MSH2 MLH1
15 adenomyoma 10.0 MLH1 KRT7
16 anal fistula 10.0 MSH2 MLH1
17 monophasic synovial sarcoma 9.9 MLH1 KRT7
18 melanocytic nevus syndrome, congenital 9.9 MSH2 MLH1
19 cecum carcinoma 9.9 MSH2 MLH1
20 familial colorectal cancer 9.9 MSH2 MLH1
21 uterine corpus cancer 9.9 MSH6 MLH1
22 bladder signet ring cell adenocarcinoma 9.9 KRT7 CDX2
23 ovary neuroendocrine neoplasm 9.9 KRT7 CDX2
24 anal canal paget's disease 9.9 KRT7 CDX2
25 anal paget's disease 9.9 KRT7 CDX2
26 ureter adenocarcinoma 9.9 KRT7 CDX2
27 gastric signet ring cell adenocarcinoma 9.9 KRT7 CDX2
28 pancreatic foamy gland adenocarcinoma 9.9 KRT7 CDX2
29 nasal cavity adenocarcinoma 9.9 KRT7 CDX2
30 anus adenocarcinoma 9.9 KRT7 CDX2
31 mucinous adenofibroma 9.9 KRT7 CDX2
32 rectum neuroendocrine neoplasm 9.9 KRT7 CDX2
33 urinary bladder villous adenoma 9.9 KRT7 CDX2
34 cystitis cystica 9.8 KRT7 CDX2
35 mucinous intrahepatic cholangiocarcinoma 9.8 KRT7 CDX2
36 intrahepatic cholangiocarcinoma 9.8 KRT7 CDX2
37 ovarian seromucinous carcinoma 9.8 KRT7 CDX2
38 vulva adenocarcinoma 9.8 KRT7 CDX2
39 krukenberg carcinoma 9.8 KRT7 CDX2
40 vaginal tubulovillous adenoma 9.8 KRT7 CDX2
41 female urethral cancer 9.8 KRT7 CDX2
42 vaginal adenoma 9.8 KRT7 CDX2
43 anal canal adenocarcinoma 9.8 KRT7 CDX2
44 mucinous ovarian cystadenoma 9.8 KRT7 CDX2
45 appendiceal neoplasm 9.8 KRT7 CDX2
46 biliary papillomatosis 9.8 KRT7 CDX2
47 vaginal benign neoplasm 9.8 KRT7 CDX2
48 glandular cystitis 9.8 KRT7 CDX2
49 linitis plastica 9.8 KRT7 CDX2
50 mucinous stomach adenocarcinoma 9.8 KRT7 CDX2

Graphical network of the top 20 diseases related to Adenosquamous Colon Carcinoma:



Diseases related to Adenosquamous Colon Carcinoma

Symptoms & Phenotypes for Adenosquamous Colon Carcinoma

UMLS symptoms related to Adenosquamous Colon Carcinoma:


constipation, fever, abdominal pain

GenomeRNAi Phenotypes related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased replication of vaccinia virus (VACV) GR00362-A 9.26 CDX2 MLH1 MSH6 PMS2
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 MLH1 MSH2 MSH6 PMS2

MGI Mouse Phenotypes related to Adenosquamous Colon Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 CDX2 KRT7 MLH1 MSH2 MSH6 PMS2
2 digestive/alimentary MP:0005381 9.46 CDX2 MLH1 MSH2 PMS2
3 homeostasis/metabolism MP:0005376 9.43 CDX2 KRT7 MLH1 MSH2 MSH6 PMS2
4 neoplasm MP:0002006 9.02 CDX2 MLH1 MSH2 MSH6 PMS2

Drugs & Therapeutics for Adenosquamous Colon Carcinoma

Search Clinical Trials , NIH Clinical Center for Adenosquamous Colon Carcinoma

Genetic Tests for Adenosquamous Colon Carcinoma

Anatomical Context for Adenosquamous Colon Carcinoma

MalaCards organs/tissues related to Adenosquamous Colon Carcinoma:

40
Colon, Appendix, Ovary, Small Intestine, Skin, Thymus, Brain

Publications for Adenosquamous Colon Carcinoma

Articles related to Adenosquamous Colon Carcinoma:

# Title Authors PMID Year
1
Colonic adenosquamous carcinoma and mucinous adenocarcinoma with microsatellite instability. 61
30173239 2018
2
An Unusual Variant of Adenocarcinoma of the Left Colon Associated With Microsatellite Instability: A Case Report. 61
28537083 2017

Variations for Adenosquamous Colon Carcinoma

Expression for Adenosquamous Colon Carcinoma

Search GEO for disease gene expression data for Adenosquamous Colon Carcinoma.

Pathways for Adenosquamous Colon Carcinoma

Pathways related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 PMS2 MSH6 MSH2 MLH1
2 12.41 MSH6 MSH2 MLH1
3 12.02 MSH6 MSH2 MLH1
4 11.72 MSH6 MSH2 MLH1
5 11.55 PMS2 MSH2 MLH1
6
Show member pathways
11.41 MSH6 MSH2
7
Show member pathways
11.23 PMS2 MSH6 MSH2 MLH1
8 11.2 MSH6 MSH2 MLH1
9 11.14 MSH6 MSH2
10
Show member pathways
11.1 MSH2 MLH1
11
Show member pathways
11.03 MSH2 MLH1
12 10.39 PMS2 MSH6 MSH2 MLH1

GO Terms for Adenosquamous Colon Carcinoma

Cellular components related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome GO:0005694 9.5 MSH6 MSH2 MLH1
2 condensed nuclear chromosome GO:0000794 9.26 MLH1 CDX2
3 MutLalpha complex GO:0032389 9.16 PMS2 MLH1
4 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
5 mismatch repair complex GO:0032300 8.92 PMS2 MSH6 MSH2 MLH1

Biological processes related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.8 PMS2 MSH6 MSH2 MLH1
2 DNA repair GO:0006281 9.76 PMS2 MSH6 MSH2 MLH1
3 determination of adult lifespan GO:0008340 9.54 MSH6 MSH2
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.54 MSH6 MSH2 MLH1
5 negative regulation of DNA recombination GO:0045910 9.52 MSH6 MSH2
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 MSH2 MLH1
7 positive regulation of helicase activity GO:0051096 9.48 MSH6 MSH2
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MSH2 MLH1
9 isotype switching GO:0045190 9.43 MSH6 MSH2 MLH1
10 maintenance of DNA repeat elements GO:0043570 9.4 MSH6 MSH2
11 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MSH6 MSH2 MLH1
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MSH2 MLH1
13 mismatch repair GO:0006298 9.26 PMS2 MSH6 MSH2 MLH1
14 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 PMS2 MSH6 MSH2 MLH1

Molecular functions related to Adenosquamous Colon Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.87 PMS2 MSH6 MSH2 MLH1
2 chromatin binding GO:0003682 9.73 MSH6 MSH2 MLH1
3 enzyme binding GO:0019899 9.71 MSH6 MSH2 MLH1
4 double-stranded DNA binding GO:0003690 9.65 MSH6 MSH2 CDX2
5 single-stranded DNA binding GO:0003697 9.63 PMS2 MSH2 MLH1
6 ATPase activity GO:0016887 9.56 PMS2 MSH6 MSH2 MLH1
7 damaged DNA binding GO:0003684 9.55 MSH6 MSH2
8 DNA-dependent ATPase activity GO:0008094 9.52 MSH6 MSH2
9 ADP binding GO:0043531 9.51 MSH6 MSH2
10 four-way junction DNA binding GO:0000400 9.49 MSH6 MSH2
11 MutSalpha complex binding GO:0032407 9.43 PMS2 MLH1
12 MutLalpha complex binding GO:0032405 9.4 MSH6 MSH2
13 oxidized purine DNA binding GO:0032357 9.37 MSH6 MSH2
14 single guanine insertion binding GO:0032142 9.32 MSH6 MSH2
15 single thymine insertion binding GO:0032143 9.16 MSH6 MSH2
16 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
17 mismatched DNA binding GO:0030983 8.92 PMS2 MSH6 MSH2 MLH1

Sources for Adenosquamous Colon Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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